Faculty Profiles - KOSAI Ken-ichiro

Papers - KOSAI Ken-ichiro

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2. Maki Watanabe, Yuya Nishikawaji, Hirotaka Kawakami, and Ken-ichiro Kosai . Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy. . Translational Reseach273 2024.11

Junichi Kamizono, Yuya Nishikawaji,Satoshi Nagano,Minako Ikeda,Yoshiharu Horikawa,Taro Kamisasanuki, Kaoru Mitsui,Eriko Matsuda,Ken-ichiro Kosai. . Triple-regulated conditionally replicating adenovirus for effective and safer treatment of peritoneal carcinomatosis. . Biochem Biophys Res Commun.737 2024.10

小戝健一郎, 西川路侑耶, 伊集院広壮, 松田恵理子, 三井薫 . 多因子増殖制御型アデノウイルスによる画期的ながん治療 . 39 ( 4 ) 248 - 259 2024.9

Maki Watanabe, Yuya Nishikawaji, Hirotaka Kawakami, and Ken-ichiro Kosai. . Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage 　in Gene Therapy. . Viruses. 2021.12

渡邉真季、西川路侑耶、小戝健一郎 . 腫瘍溶解性アデノウイルスの作製・調製法と次世代の癌免疫治療への応用・展望 . 創薬研究者がこれだけは知っておきたい最新のウイルス学 397 - 403 2021.8

Eriko Matsuda, Yuki Obama, Ken-ichiro Kosai. . Safe and low-dose but therapeutically elective adenovirus-mediated hepatocyte growth factor gene therapy for type 1 diabetes in mice . Life Sci268 119014 - 119014 2021.3Reviewed

Kaoru Mitsui, Tomoyuki Takahashi, Kanako Ide, Eriko Matsuda, Ken-ichiro Kosai. . Optimization of Adenoviral Gene Transfer in Human Pluripotent Stem Cells . Biochem Biophys Res Commun.541 78 - 83 2021.2Reviewed

Suzuki S, Kofune H, Uozumi K, Yoshimitsu M, Arima N, Ishitsuka K, Ueno S and Kosai K. . A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma . BMC Cancer19 ( 1 ) 516 - 516 2019.5Reviewed

Ide K, Mitsui K, Irie R, Matsushita Y, Ijichi N, Toyodome S, Kosai K. . A Novel Construction of Lentiviral Vectors for Eliminating Tumorigenic Cells from Pluripotent Stem Cells . Stem Cells36 230 - 239 2018.10Reviewed

Kida H, Takahashi T, Nakamura Y, Kinoshita T, Hara M, Okamoto M, Okayama S, Nakamura　K, Kosai K, Taniwaki T, Yamashita Y, Matsuishi T. . Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome . Scientific Reports7 ( 12032 ) 1 - 13 2017.9Reviewed

Sakamoto K, Khai NC, Wang Y, Irie R, Takamatsu H, Matsufuji H, Kosai K. . Heparin-Binding Epidermal Growth Factor–Like Growth Factor and Hepatocyte Growth Factor Inhibit Cholestatic Liver Injury in Mice via Different Actions . International Journal of Molecular Medicine38 ( 6 ) 1673 - 1682 2016.10

Miyazaki Y, Matsubara S, Qiang Ding, Tsukasa K, Yoshimitsu M, Kosai K, Takao S. . Efficient elimination of pancreatic cancer stem cells by Hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition . Molecular Cancer15 ( 1 ) 49 2016.6Reviewed

Goto K, Takemura G, Takahashi T, Okada H, Kanamori H, Kawamura I, Watanabe T, Morishita K, Tsujimoto A, Miyazaki N, Ushikoshi H, Kawasaki M, Mikami A, Kosai K, Minatoguchi S. . Intravenous administration of endothelial colony-forming cells overexpressing integrin b1 augments angiogenesis in ischemic legs . Stem Cells Transl Med5 ( 2 ) 218 - 226 2015.12

Hara M, Takahashi T, Mitsumasu C, Igata S, Takano M, Minami T, Yasukawa H, Okayama S, Nakamura K, Okabe Y, Tanaka E, Takemura G, Kosai K, Yamashita Y, Matsuishi T. . Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias . Scientific Reports 2015.6Reviewed

Mitsui K, Ide K, Takayama A, Wada T, Irie R, Kosai K. . Conditionally replicating adenovirus prevents pluripotent stem cell-derived teratoma by specifically eliminating undifferentiated cells . Mol Ther Methods Clin Dev. 2015.5

Mitsui K, Ide K, Takayama A, Wada T, Irie R, Kosai K.I22:I23 . Conditionally replicating adenovirus prevents pluripotent stem cell-derived teratoma by specifically eliminating undifferentiated cells . Mol Ther Methods Clin Dev2 2015.1International coauthorship

Yuge K, Takahashi T, Khai NC, Goto K, Fujiwara T, Fujiwara H, Kosai K. . Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice . Int J Mol Med33 ( 5 ) 1064 - 1074 2014.3Reviewed

Tanoue K, Wang Y, Ikeda M , Mitsui K, Irie R , Setoguchi T, Komiya S, Natsugoe S, Kosai K. . Survivin-responsive conditionally replicating adenovirus kills rhabdomyosarcoma stem cells more efficiently than their progeny . J Trans Med12 2014.1Reviewed

Okabe Y, Takahashi T, Mitsumasu C, Kosai K, Tanaka E, Matsuishi T. . Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-null Mouse Model of Rett Syndrome . PLoS ONE7 ( 4 ) 2012.4Reviewed

Shinjiro Hino, Akihisa Sakamoto, Katsuya Nagaoka, Kotaro Anan, Yuqing Wang, Shinya Mimasu, Takashi Umehara, Shigeyuki Yokoyama, Ken-ichiro Kosai, Mitsuyoshi Nakao . FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure . Nature Commun27 ( 3 ) 2012.3Reviewed

Taro Kamisasanuki, Saori Tokushige, Hiroto Terasaki, Ngin Cin Khai,Yuqing Wang, Taiji Sakamoto, Ken-ichiro Kosai. . Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: A novel antiangiogenic therapy . Biochem Biophys Res Commun16 ( 413 ) 128 - 135 2011.9Reviewed

Yoshiharu Horikawa, Yuqing Wang, Satoshi Nagano, Jun-ichi Kamizono, Minako Ikeda, Setsuro Komiya, Ken-ichiro Kosai. . Assessment of an altered E1B promoter on the specificity and potency of triple-regulated conditionally replicating adenoviruses: implications for the generation of ideal m-CRAs . Cancer Gene Therapy18 ( 10 ) 724 - 733 2011.8Reviewed

Ken-ichi Murakami, Tatsuru Kaji, Ryuichi Shimono, Yoshihiro Hayashida, Hiroshi Matsufuji, Shinichiro Tsuyama, Rie Maezono, Ken-ichiro Kosai, Hideo Takamatsu. . Therapeutic effects of vitamin A on experimental cholestatic rats with hepatic fibrosis . Pediatr Surg Int27 ( 6 ) 863 - 870 2011.8Reviewed

Ngin Cin Khai, Kouichi Sakamoto, Hideo Takamatsu, Hiroshi Matsufuji, Ken-ichiro Kosai. . Recombinant soluble form of HB-EGF protein therapy drastically inhibits Fas-mediated fulminant hepatic failure: Implications in clinical application . Hepatol Res41 ( 6 ) 594 - 596 2011.2Reviewed

Yasunori Okabe, Akira Kusanaga, Tomoyuki Takahashi, Chiaki Mitsumasu, Yoshinaka Murai, Eiichiro Tanaka, Hideo Higashi, Toyojiro Matsuishi, Ken-ichiro Kosai. . Neural Development of Methyl-CpG-Binding Protein 2 Null Embryonic Stem Cells: A System for Studying Rett Syndrome . Brain Res1360 ( 11 ) 17 - 27 2010.11Reviewed

Miyata S, Takemura G, Kosai KI, Takahashi T, Esaki M, Li L, Kanamori H, Maruyama R, Goto K, Tsujimoto A, Takeyama T, Kawaguchi T, Ohno T, Nishigaki K, Fujiwara T, Fujiwara H, Minatoguchi S. . Anti-Fas Gene Therapy Prevents Doxorubicin-induced Acute Cardiotoxicity through Mechanisms Independent of Apoptosis . Am J Pathol176 ( 2 ) 687 - 698 2010.2Reviewed

Li L, Okada H, Takemura G, Kosai KI, Kanamori H, Esaki M, Takahashi T, Goto K, Tsujimoto A, Maruyama R, Kawamura I, Kawaguchi T, Takeyama T, Fujiwara T, Fujiwara H, Minatoguchi S. . Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction . Am J Physiol Heart Circ Physiol97 ( 4 ) 1504 - 1513 2009.8Reviewed

Umeno H, Chitose S, Murofushi Y, Kosai K, Sato K, Kawahara A, Nakashima T. . Efficacy of autologous fat injection laryngoplasty with an adenoviral vector expressing hepatocyte growth factor in a canine model . J Laryngol Otol123 ( 31 ) 24 - 29 2009.5Reviewed

Okada H, Takemura G, Kosai K, Tsujimoto A, Esaki M, Takahashi T, Nagano S, Kanamori H, Miyata S, Li Y, Ohno T, Maruyama R, Ogino A, Li L, Nakagawa M, Nagashima K, Fujiwara T, Fujiwara H, Minatoguchi S. . Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure . Am J Physiol Heart Circ Physiol296 ( 3 ) 616 - 626 2009.1Reviewed

Kondo T, Takemura G, Kosai K, Ohno T, Takahashi T, Esaki M, Goto K, Maruyama R, Murata I, Minatoguchi S, Fujiwara T, Fujiwara H. . Application of an adenoviral vector encoding soluble transforming growth factor-beta type II receptor to the treatment of diabetic nephropathy in mice . Clin Exp Pharmacol Physiol35 ( 11 ) 1288 - 1293 2008.10Reviewed

Esaki M, Takemura G, Kosai KI, Takahashi T, Miyata S, Li L, Goto K, Maruyama R, Okada H, Kanamori, H, Ogino A, Ushikoshi H, Minatoguchi S, Fujiwara T, Fujiwara H. . Treatment with an adenoviral vector encoding hepatosyte growth factor mitigates established cardiac dysfunction in doxorubicin -induced cardiomyopathy . Am J Physiol Heart Circ Physiol294 ( 2 ) 1048 - 1057 2007.12Reviewed

Chen XH, Minatoguchi S, Kosai K, Yuge K, Takahashi T, Arai M, Wang N, Misao Y, Lu C, Onogi H, Kobayashi H, Yasuda S, Ezaki M, Ushikoshi H, Takemura G, Fujiwara T, Fujiwara H. . In vivo hepatocyte growth factor gene transfer reduces myocardial ischemiareperfusion injury through its multiple actions . J Card Fail13 ( 10 ) 874 - 883 2007.12Reviewed

Takahashi T, Kawai T, Ushikoshi H, Nagano S, Oshika H, Inoue M, Kunisada T, Takemura G, Fujiwara H, Kosai K. . Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting . Mol Ther14 673 - 683 2006.11Reviewed

Murofushi Y, Nagano S, Kamizono J, Takahashi T, Fujiwara H, Komiya S, Matsuishi T, and Kosai K. . Cell cycle-specific changes in hTERT promoter activity in normal and cancerous cells in adenoviral gene therapy: A promising implication of telomerase-dependent targeted cancer gene therapy . Int J Oncol29 681 - 688 2006.9Reviewed

Khai NC, Takahashi T, Ushikoshi H, Nagano S, Yuge K, Esaki M, Kawai T, Goto K, Murofushi Y, Fujiwara T, Fujiwara H, Kosai K. . In vivo hepatic HB-EGF gene transduction inhibits Fas-induced liver injury and induces liver regeneration in mice: A comparative study to HGF . J. Hepatol44 1046 - 1054 2006.6Reviewed

Misao Y, Takemura G, Arai M, Sato S, Suzuki K, Miyata S, Kosai K, Minatoguchi S, Fujiwara T, Fujiwara H. . Bone marrow-derived myocyte-like cells and regulation of repair-related cytokines after bone marrow cell transplantation . Cardiovasc Res69 476 - 490 2006.2Reviewed

Kagawa T., Takemura G., Kosai K., Murata I., Ohno T., Takahashi T., Esaki M., Maruyama R., Fujiwara T., Ohashi H., Fujiwara H. . Hepatocyte growth factor gene therapy slows down the progression of diabetic nephropathy in db/db mice . Nephron Physiol102 92 - 102 2006.2Reviewed

Kuge H, Ohashi K, Yokoyama T, Kanehiro H, Hisanaga M, Koyama F, Bumgardner GL, Kosai K, Nakajima Y. . Genetic modification of hepatocytes towards hepatocyte transplantation and liver tissue engineering . Cell Transplant15 1 - 12 2006Reviewed

Yuge K, Takahashi T, Nagano S, Terazaki Y, Murofushi Y, Ushikoshi H, Kawai T, Khai NC, Nakamura T, Fujiwara H, Kosai K. . Adenoviral Gene Transduction of Hepatocyte Growth Factor Elicits Inhibitory Effects for Hepatoma . Int J Oncol27 77 - 85 2005.7Reviewed

Kamizono J, Nagano S, Murofushi Y, Komiya S, Fujiwara H, Matsuishi T, Kosai K. . Survivin-responsive conditionally replicating adenovirus exhibits cancer-specific and efficient viral replication . Cancer Res65 5284 - 5291 2005.6Reviewed

Tada T, Nguyen JB, Hitoshi Y, Watson NP, Dunn JF, Ohara S, Nagano S, Kosai K, Israel MA. . Diffuse Encephaloventriculitis and Substantial Leukoencephalopathy after Intraventricular Administration of Recombinant Adenovirus . Neurol Res27 378 - 386 2005.6Reviewed

Nagano S, Oshika H, Fujiwara H, Komiya S, Kosai K. . An Efficient Construction of Conditionally Replicating Adenoviruses that Target Tumor Cells with Multiple Factors . Gene Ther12 1385 - 1393 2005.5Reviewed

Okada H, Takemura G, Kosai K, Li Y, Takahashi T, Esaki M, Yuge K, Miyata S, Maruyama R, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H. . Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure . Circulation111 2430 - 2437 2005.5Reviewed

Ushikoshi H, Takahashi T, Chen X, Khai NC, Esaki M, Goto K, Takemura G, Maruyama R, Minatoguchi S, Fujiwara T, Nagano S, Yuge K, Kawai T, Murofushi Y, Fujiwara H, Kosai K. . Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes . Lab Invest85 862 - 873 2005.4Reviewed

神囿淳一，永野聡，小宮節郎，小戝健一郎 . Survivin依存性増殖制御型アデノウイルスを用いた骨軟部腫瘍に対する遺伝子治療法の開発 . 日本整形外科学会誌79 ( 8 ) S896 - S896 2005

Li Y, Takemura G, Kosai K, Takahashi T, Okada H, Miyata S, Yuge K, Nagano S, Esaki M, Khai NC, Goto K, Mikami A, Maruyama R, Minatoguchi S, Fujiwara T Fujiwara H. . Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure . Circ.Res95 27 - 36 2004.8Reviewed

Kawai T, Takahashi T, Esaki M, Ushikoshi H, Nagano S, Fujiwara H, Kosai K. . Efficient cardiomyogeneic differentiation of embryonic stem cell by FGF-2 and BMP-2 . Circ. J68 691 - 702 2004.7Reviewed

Hisaka Y, Ieda M, Nakamura T, Kosai K, Ogawa S, Fukuda K. . Powerful and controllable angiogenesis by using gene-modified cells expressing human hepatocyte growth factor and thymidine kinase . J Am Coll Cardiol43 1915 - 1922 2004.5Reviewed

Iida SI, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H. . Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G(1) tetraploidy checkpoint function . Oncogene23 5266 - 5274 2004.5Reviewed

Minatoguchi S, Takemura G, Chen XH, Wang N, Uno Y, Koda M, Arai M, Misao Y, Lu C, Suzuki K, Goto K, Komada A, Takahashi T, KosaiI57:I58 K, Fujiwara T, Fujiwara H. . Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment . Circulation109 2572 - 2580 2004.5Reviewed

Nagano S, Yuge K, Fukunaga M, Terazaki Y, Fujiwara H, Komiya S, Kosai K. . Gene Therapy eradicating distant disseminated micro-metastases by optimal cytokine expression in the primary lesion only -novel concepts for successful cytokine gene therapy . Int. J. Oncol24 549 - 558 2004.3Reviewed

Ikoma T, Takahashi T, Nagano S, Li Y-M, Ohno Y, Ando K, Fujiwara T, Fujiwara H and Kosai K. . A definitive role of RhoC in metastasis of orthotopic lung cancer in mice . Clin Cancer Res 2004.2

神囿淳一，永野聡，小宮節郎，小戝健一郎 . 癌特異的増殖制御型アデノウイルスベクターを用いた骨軟部腫瘍に対する遺伝子治療 . 日本整形外科学会誌78 ( 6 ) S682 - S682 2004

Li Y, Takemura G, Kosai K, Yuge K, Nagano S, Esaki M, Goto K, Takahashi T, Hayakawa K, Koda M, Kawase Y, Maruyama R, Okada H, Minatoguchi S, Mizuguchi H, Fujiwara T, Fujiwara H. . Postinfarct treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice . Circulation 2003.4

Himeno W, Akagi T, Furui A, Maeno Y, Ishii M, Kosai K, Murohara T, Kato H. . Increased angiogenic growth factor in cyanotic congenital heart disease . Pediatr Cardiol24 ( 2 ) 127 - 132 2003.3

Terazaki Y, Yano S, Yuge K, Nagano S, Fukunaga M, Guo ZS, Komiya S, Shirouzu K, Kosai, K. . An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice . Hepatology37 ( 1 ) 155 - 163 2003.1

Tsuneoka M, Umata T, Kimura H, Koda Y, Nakajima M, Kosai K, Takahashi T, Takahashi Y, Yamamoto A. . c-myc induces autophagy in rat 3Y1 fibroblast cells . Cell Struct Funct. 2003

Yoshida T, Hanada T, Tokuhisa T, Kosai K, Sata M, Kohara M, Yoshimura A. . Activation of STAT3 by the Hepatitis C virus core protein leads to cellular transformation . J. Exp. Med196 ( 5 ) 641 - 653 2002.9

Aoyama T, Takemura G, Maruyama R, Kosai K, Takahashi T, Koda M, Hayakawa K, Kawase Y, Minatoguchi S, Fujiwara H. . Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes . Cardiovasc Res55 ( 4 ) 787 - 798 2002.9

Fukunaga M, Takamori S, Hayashi A, Shirouzu K, Kosai K. . Adenoviral herpes simplex virus thymidine kinase gene therapy in an orthotopic lung cancer model . Ann Thorac Surg73 ( 6 ) 1740 - 1746 2002.6

Shouda T, Yoshida T, Hanada T, Wakioka T, Oishi M, Miyoshi K, Komiya S, Kosai K, Hanakawa Y, Hashimoto K, Nagata K, Yoshimura A. . Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis . J Clin Invest108 ( 12 ) 1781 - 1788 2001.12

Miyado K, Yamada G, Yamada S, Hasuwa H, Nakamura Y, Ryu F, Suzuki K, Kosai K, Inoue K, Ogura A, Okabe M, Mekada E. . Requirement of CD9 on the egg plasma membrane for fertilization . Science 287 ( 5451 ) 321 - 324 2000.1

Kosai K, Matsumoto K, Funakoshi H, Nakamura T. . Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice . Hepatology30 ( 1 ) 151 - 159 1999.7

Kuratani S, Satokata I, Blum M, Komatsu Y, Haraguchi R, Nakamura S, Suzuki K, Kosai K, Mass R, Yamada G. . Middle ear defects associated with the double knockout mutation of murine Goosecoid and Msx1 genes . Cell. Mol. Biol45 ( 5 ) 589 - 599 1999.7

Timchenko NA, Wilde M, Kosai KI, Heydari A, Biyeu TA, Finegold MJ, Mohamedali K, Richardson A, Darlington GJ. . Regenerating livers of old rats contain high levels of C/EBPalpha that correlate with altered expression of cell cycle associated proteins . Nucleic acids Res26 ( 13 ) 3293 - 3299 1998.7

Kosai K, Finegold MJ, Thi-Huynh BT, Tewson M, Ou CN, Bowles N, Woo SL, Schwall RH, Darlington GJ. . Retrovirus-mediated in vivo gene transfer in the replicating liver using recombinant hepatocyte growth factor without liver injury or partial hepatectomy . Human Gene Ther9 ( 9 ) 1293 - 1301 1998.6

Kosai K, Matsumoto K, Nagata S, Tsujimoto Y, Nakamura T. . Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor . Biochem. Biophys. Res. Commun244 ( 3 ) 3293 - 3299 1998.3

Kwong YL, Chen S-H, Kosai K, Finegold MJ, Woo SL. . Combination therapy with suicide and cytokine genes for hepatic metastases of lung cancer . Chest112 ( 5 ) 1332 - 1337 1997.11

Kage M, Ogasawara S, Kosai K, Nakashima E, Shimamatsu K, Kojiro M, Kimura A, Fujisawa T, Matsukuma Y, Ito Y, Kondo S, Kawano K, Sata M. . Hepatitis C virus RNA present in saliva but absent in breast-milk of the hepatitis C carrier mother . J. Gastroenterol. Hepatol12 ( 7 ) 518 - 521 1997.7

O’Malley BW Jr, Sewell DA, Li D, Kosai K, Chen SH, Woo SL, Duan L. . The role of interleukin-2 in combination adenovirus gene therapy for head and neck cancer . Mol Endocrinol11 ( 6 ) 667 - 673 1997.6

Huang H, Chen S-H, Kosai K, Finegold MJ, Woo SL. . Gene therapy for hepatocellular carcinoma: long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo . Gene Ther3 ( 11 ) 980 - 987 1996.11

Caruso M, Pham-Nguyen K, Kwong Y-L, Xu B, Kosai K, Finegold MJ, Woo SL. . Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma . Proc. Natl. Acad. Sci. USA93 ( 21 ) 11302 - 11306 1996.10

Kwong Y-L, Chen S-H, Kosai K, Finegold MJ, Woo SL. . Adenoviral-mediated suicide gene therapy for hepatic metastases of breast cancer . Cancer Gene Ther3 ( 5 ) 339 - 344 1996.9

Chen S-H, Kosai K, Xu B, Pham-Nguyen K, Contant C, Finegold MJ, Woo SL. . Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: Sustained antitumor immunity prolongs animal survival . Cancer Res56 ( 16 ) 3758 - 3762 1996.8

Bonnekoh B, Greenhalgh DA, Bundman DS, Kosai K, Chen S-H, Finegold MJ, Krieg T, Woo SL, Roop DR. . Adenoviral-mediated herpes simplex virus-thymidine kinase gene transfer in vivo for treatment of experimental human melanoma . J. Invest. Dermatol106 ( 6 ) 1163 - 1168 1996.6

Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: Regression of hepatic metastasis of pancreaticc tumors. . Pancreas.15 ( 1 ) 25 - 34 1996

Kimura K, Yuge K, Kosai K, Kage M, Fujisawa T, Inoue T, Yamashita Y, Nakashima E, Kato. . Neonatal cholestasis in two siblings: a variant of Dubin-Johnson syndrome? . J. Paediatr. Child. Health31 ( 6 ) 557 - 560 1995.12

Chen S-H, Chen XHL, Wang Y, Kosai K, Finegold MJ, Rich S, Woo SL. . Combination gene therapy for liver metastasis of colon carcinoma in vivo . Proc. Natl. Acad. Sci. USA92 ( 7 ) 942 - 944 1995.3

藤沢卓爾, 小戝健一郎, 小笠原幸子, 鹿毛政義, 中嶋英輔, 松隈義則, 木村昭彦, 加藤裕久 . 末梢血リンパ球及び肝組織中Polymerase chain reaction法による乳幼児サイトメガロウイルス肝炎の診断的有用性 . 日本小児科学会雑誌98 1437 - 1438 1994

Kage M, Kosai K, Kojiro M, Nakamura Y, Fukuda S. . Infantile cholestasis due to cytomegalovirus infection of the liver. A possible cause of paucity of interlobular bile ducts . Arch. Pathol. Lab. Med117 ( 9 ) 942 - 944 1993.3

Ogasawara S, Kage M, Kosai K, Shimamatsu K, Kojiro M. . Hepatitis C virus RNA in saliva and breastmilk of hepatitis C carrier mothers . Lancet341 ( 8844 ) 561 - 561 1993.2

本廣孝，丸岡隆之，長井健祐，沖眞一郎，津村直幹，佐々木宏和，荒巻雅史，古賀達彦，小戝健一郎 . 新生児、未熟児におけるFlomoxefの基礎的・臨床的検討 . Japanese journal of antibiotics46 ( 7 ) 547 - 567 1993

Kage M, Kosai K, Shimamatsu K, Nakashima O, Haramaki M, Yasunaga M, Iha H, Kojiro M, Govindarajan S. . Incidence of hepatitis D virus infection in Japanese patients with hepatocellular carcinoma--immunohistochemical investigation of the delta antigen . Kurume Medical Journal39 ( 4 ) 231 - 234 1992

Kage M, Kosai K, Shimamatsu K, Kojiro M, Haramaki M, Yasunaga M, Iha H, Harada A. . Ultrastructural studies of the bile duct in alcoholic liver disease . Kurume Medical Journal39 ( 4 ) 219 - 299 1992

小戝健一郎, 鹿毛正義, 神代正道, 山川良一, 松行真門, 木村昭彦 . 新生児発症のDubin-Johnson syndrome兄弟例の組織学的検討 . Minophagen Medical Review37 384 - 385 1992

小戝健一郎, 鹿毛政義, 神代正道 . 胆道閉鎖症予後不良例についての検討 -日本病理剖検輯報に基づく検討- . 日本小児栄養消化器病学会誌6 151 - 157 1992

Kosai K, Kage M, Kojiro M. . Clinicopathological study of liver involvement in cytomegalovirus infection in infant autopsy cases . J. Gastroenterol. Hepatol6 ( 6 ) 603 - 608 1991.12

鹿毛政義, 小戝健一郎, 神代正道 . Indian childhood cirrhosisの肝病理形態について . Minophagen Medical Review36 349 - 350 1991

11. 赤木保久, 自見厚郎, 小戝健一郎, 神代正道, 森松稔, 加来信雄 . パラコート中毒症における腎障害—25剖検例の臨床病理学的検討— . 総合臨床40 543 - 548 1991

小戝健一郎, 弓削建, 小野栄一郎, 橋本信男, 太田喜孝, 鹿毛政義 . HBs抗原サブタイプaywによるGianotti病の姉妹例—本邦散発例のHBs抗原サブタイプの検討— . 日本小児栄養消化器病学会誌5 294 - 302 1991

小戝健一郎, 鹿毛政義, 神代正道 . 乳児サイトメガロウイルス感染肝の臨床病理学的研究 . Minophagen Medical Review49 411 - 412 1991

Katafuchi Y, Kosai K, Ohtaki E, Yamashita Y, Horikawa M, Terasawa M, Nonaka I. . Cerebral cortex and brainstem involvement in Marinesco-Sjögren syndrome . Ann. Neurol27 ( 4 ) 448 - 449 1990.4

鹿毛政義, 小戝健一郎, 神代正道, 井上長三, 矢野右人 . C型肝炎の病理 . 臨床科学26 1579 - 1586 1990

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Papers - KOSAI Ken-ichiro