ライフサイエンス / 病態系口腔科学

ライフサイエンス / 腫瘍生物学

ライフサイエンス / ウイルス学

ライフサイエンス / 病態系口腔科学

ライフサイエンス / 常態系口腔科学

ライフサイエンス / 分子生物学

ライフサイエンス / 実験病理学

広島大学   広島大学病院   研究員

2019年1月 - 2021年3月

広島大学   広島大学大学院医系科学研究科（歯）   助教

2014年1月 - 2018年12月

広島大学   広島大学大学院医系科学研究科（歯）   研究員

2011年10月 - 2013年10月

広島大学   広島大学大学院医系科学研究科（歯）   助手

2008年10月 - 2011年9月

ホーチミン医科薬科大学   口腔病理学   講師

2006年10月 - 2008年9月

奥 康伸, Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則 .  細胞質内のTCF19転座はHNSCCにおけるDNA損傷修復を阻害する(Cytoplasmic TCF19 translocation impairs DNA damage repair in HNSCC) .  日本病理学会会誌112 ( 1 ) 387 - 387   2023年3月

冨嶋 彩未, Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則 .  口腔癌におけるMCTP1とMCTP2の機能的な差異についての検討 .  日本病理学会会誌112 ( 1 ) 388 - 388   2023年3月

嶋 香織, Nguyen Phuong Thao, 下拾石 雄大, 笹平 智則 .  口腔扁平上皮癌におけるMETTL5発現と機能の解析 .  日本病理学会会誌112 ( 1 ) 289 - 290   2023年3月

Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則 .  KPNA7の増幅および過剰発現がHNSCCの腫瘍浸潤免疫細胞に及ぼす影響(Impacts of KPNA7 amplification and overexpression on tumor infiltrating immune cells of HNSCCs) .  日本病理学会会誌112 ( 1 ) 291 - 291   2023年3月

Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則 .  EPS8L3はYAPの核内移行を仲介し肝腫瘍化を促進する(EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis) .  日本病理学会会誌112 ( 1 ) 295 - 295   2023年3月

Hoang Trong Hung, Phuong Thao Nguyen, Nam Cong Nhat Huynh, Tam Thi Thanh Nguyen, Trang Thi Huyen Tu, Michael George Botelho, Lan Van Nguyen, Kaori Shima, Tomonori Sasahira .  Reliability of online dental final exams in the pre and post COVID-19 era: A comparative study .  PLOS ONE   2023年査読 国際共著

嶋 香織, Nguyen Phuong Thao, 下拾石雄大, 笹平 智則 .  上顎に生じた Primordial odontogenic tumor の2例 .  診断病理40 ( 3 ) 265 - 271   2023年査読

Kaori Shima, Phuong Thao Nguyen, Yudai Shimojukkoku, Yuka Kajiya, Tomonori Sasahira .  Solitary circumscribed neuroma of the upper lip: A case report .  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2023年

Nguyen PT, Kanno K, Pham QT, Kikuchi Y, Kakimoto M, Kobayashi T, Otani Y, Kishikawa N, Miyauchi M, Arihiro K, Ito M, Tazuma S .  Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma .  Journal of Cancer Research and Clinical Oncology146   3255 - 3268   2021年査読

Kobayashi T, Kanno K, Nguyen PT, Sugiyama A, Kawahara A, Otani Y, Kishikawa N, Ito M, Tazuma S .  Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis .  Journal of Gastroenterology and Hepatology35   2140 - 2150   2020年12月査読

Ohigashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Kobayashi T, Matsuo H, Tazuma S .  Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyte .  J Hepatobiliary Pacreat Sci26   568 - 577   2019年12月査読

Kobayashi T, Kanno K, Nguyen PT, Kishikawa N, Tazuma S .  Molecular mechanism in which periostin induces hepatic steatosis in vivo and in vitro .  Hepatology70   1286 - 1286   2019年5月査読

Nguyen PT, Kanno K, Pham T, Kobayashi T, Tazuma S .  Deoxycholic acid-Induced senescent hepatic stellate cell promote malignant behaviors of hepatocellular carcinogenesis .  Gastroenterology156   2019年5月査読

Chea C, Miyauchi M, Inubushi T, Okamoto K, Haing S, Nguyen PT, Imanaka H, Takata T .  Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition in oral squamous cell carcinoma .  Biochem Biophys Res Commun502   142 - 147   2018年12月査読

Nguyen PT, Nguyen D, Chea C, Miyauchi M, Fujii M, Takata T .  Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer .  Oncotarget9   31516 - 31530   2018年7月査読

Kobayashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Tazuma S .  Periostin Antisense Oligonucleotide Prevents Hepatic Steatosis and Fibrosis in Mice: A novel strategy for Nonalcoholic Steatohepatitis Treatment .  Hepatology68   2018年5月査読

Oka H, Ishida Y, Hong G, Nguyen PT .  Perceptions of dental students in Japanese national universities about studying abroad .  Eur J Dent Educ22   e1 - e6   2018年2月査読 国際共著

Chea C, Miyauchi M, Inubushi T, N, Subarnbhesaj A, Nguyen PT, Shestha M, Haing S, Ohta K, Takata T .  Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma .  PLOS ONE13   e0191683   2018年1月査読

Subarnbhesaj A, Miyauchi M, Mikuriya A, Nguyen PT, Chanbora C, Ayunintyas NF, Fujita M, Niida S, Takata T .  Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma .  PLOS ONE12   e0187092   2017年11月査読

Subarnbhesaj A, Miyauchi M, Chea C, Nurina FA, Nguyen PT, Takata T .  Role of VEGF-Flt-1 Signaling in Oral Cancer Progression .  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology119   136 - 137   2015年3月査読

Nguyen PT, Subarnbhesaj A, Miyauchi M, Ogawa I, Takata T .  The FGFR1 inhibitor PD173074 reduces osteoclastogenesis in gingival squamous cell carcinoma .  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology119   172 - 172   2015年3月査読

Nguyen PT, Tsunematsu T, Yanagisawa S, Kudo Y, Miyauchi M, Kamata N, Takata T .  The FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP- 1 .  British Journal Cancer109   2248 - 2258   2013年10月査読

Yasusei Kudo , Shinji Iizuka, Maki Yoshida, Phuong Thao Nguyen, Samadarani B S M Siriwardena, Takaaki Tsunematsu, Mariko Ohbayashi, Toshinori Ando, Daijiro Hatakeyama, Toshiyuki Shibata, Keiichi Koizumi, Masahiro Maeda, Naozumi Ishimaru, Ikuko Ogawa, Takashi Takata .  Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer .  PLOS ONE7   1 - 14   2012年8月査読

Nguyen PT, Kudo Y, Yoshida M, Takata T .  N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial- mesenchymal transition .  Histol Histopathol 26   147 - 156   2011年2月査読

Nguyen PT, Kudo Y, Yoshida M, Iizuka S, Ogawa I, Takata T .  N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region .  Journal of Oral Pathology and Medicine 40   77 - 82   2011年1月査読

SL Priebe, J Aleksejūnienė, C Zed, S Dharamsi, DHQ Thinh, NT Hong, TTK Cuc, Nguyen PT .  Oral squamous cell carcinoma and cultural oral risk habits in Vietnam .  International Journal of Dental Hygiene8   159 - 168   2010年8月査読 国際共著

下拾石 雄大, Phuong Thao NGUYEN, 嶋 香織, 石田喬之, 笹平智則 .  Functional analysis of EGR-1 as a tumor suppressor gene in oral squamous cell carcinoma .  第65回歯科基礎医学会  2023年9月  歯科基礎医学会

Phuong Thao Nguyen, Kaori Shima, Yudai Shimojukkoku, Yuka Kajiya, Tomonori Sasahira .  Amplication of the nuclear import receptor KPNA7 is associated with poor overall survival in head and neck cancer .  第82回日本癌学会  2023年9月  日本癌学会

Kaori Shima, Phuong Thao Nguyen, Yudai Shimojukkoku, Tomonori Sasahira .  Analysis of METTL5, a m6A methyltransferase, expression in oral squamous cell carcinoma .  第65回歯科基礎医学会  2023年9月  歯科基礎医学会

Shima K, Nguyen PT, Shimojukkoku Y, Sasahira T .  Analysis of METTL5 expression and function in oral squamous cell carcinoma. .  The 112th annual meeting of The Japanese Society Pathology   2023年4月  The Japanese Society Pathology

Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T .  Impacts of KPNA7 amplification and overexpression on tumor infiltrating immune cells of HNSCCs .  The 112th annual meeting of The Japanese Society Pathology   2023年4月  The Japanese Society Pathology

Tomishima A, Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T .  The roles of MCTP2 in oral squamous cell carcinoma. .  The 112th annual meeting of The Japanese Society Pathology   2023年4月  The Japanese Society Pathology

Oku Y, Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T .  Cytoplasmic TCF19 translocation impairs DNA damage repair in HNSCC. .  The 112th annual meeting of The Japanese Society Pathology   2023年4月  The Japanese Society Pathology

Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T. .  EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis. .  The 112th annual meeting of The Japanese Society Pathology   2023年4月  The Japanese Society Pathology

Nguyen PT, Shima K, Sasahira T .  New insights into YAP nuclear translocation to promote liver tumorigenesis .  The 81st annual meeting of Japanese Cancer Association   2022年9月  Japanese Cancer Association 国際会議

Nguyen PT, Kanno K, Pham QT, Kobayashi T, Miyauchi M, Arihiro K, Tazuma S, Ito M .  Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma .  The 43rd annual meeting of The molecular Biology Society in Japan  2020年  The molecular Biology Society in Japan国際会議

Nguyen PT, Tazuma S, Otani Y, Ito M .  Contributions of hepatic stellate cells into hepatocellular carcinoma .  The 79th annual meeting of Japanese Cancer Association  2020年  Japanese Cancer Association国際会議

Juraev J, Matsumoto M, Kanno K, Nguyen PT, Tazuma S .  Geographic distribution of X-Ray, CT and MRI devices: a comparison between Japan and Uzbekistan .  Wonca  2019年  World Organization of Family Doctors国際会議

Nguyen PT, Kanno K, Pham QT, Kobayashi T, Tazuma S. .  Deoxycholic acid-induced senescent hepatic stellate cells generate inflammatory tumor microenvironment that drives progression in hepatocellular carcinoma .  The 41st Bile acid meeting   2019年 

Kobayashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Tazuma S .  Molecular mechanism in which periostin induces hepatic steatosis in vivo and in vitro .  71st Annual Meeting of American Association for the Study of Liver Disease   2019年  American Association for the study of liver diseases国際会議

Nguyen PT, Kanno K, Pham T, Kobayashi T, Kishikawa N, Otani Y, Tazuma S .  Deoxycholic acid-Induced senescent hepatic stellate cell promote malignant behaviors of hepatocellular carcinogenesis: Implication to Underlying Mechanisms of Metabolic Syndrome-Based Fatty liver and carcinogenesis .  120th Annual Meeting of American Gastroenterological Association   2019年  American Gastroenterological Association国際会議

Nguyen PT, Kanno K, Pham T, Kobayashi T, Tazuma S .  Deoxycholic acid-induced senescent hepatic stellate cells promote invasion and metastasis of hepatocellular carcinoma cells .  The 40th Bile acid meeting  2018年  Japanese Bile Acid Association

Ohigashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Kobayashi T, Matsuo H, Tazuma S .  Protective effect of phosphatidylcholine on lypophosphatidylcholine-induced cellular senescence in cholangiocyte .  The 40th Bile acid meeting   2018年 

Nguyen PT, Miyauchi M, Fujii M .  The role of molecular triad PlGF/ Flt1/ MMP1 in bone invasion of gingival squamous cell carcinoma. .  The 76th annual meeting of Japanese Cancer Association   2017年  Japanese Cancer Asssociation国際会議

Kobayashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Tazuma S .  Periostin Antisense Oligonucleotide Prevents Hepatic Steatosis and Fibrosis in Mice: A novel strategy for Nonalcoholic Steatohepatitis Treatment .  70th Annual Meeting of American Association for the Study of Liver Disease   2017年  American Association for the study of liver diseases国際会議

Nguyen PT, Nguyen D, Miyauchi M, Fujii M, Takata T. .  Overexpression of N-cadherin induces anti-apoptosis effects on cancer cells through TRAIL receptors and caspase pathway .  The 27th Annual Meeting of the Japanese Society of Oral Pathology  2016年  the Japanese Society of Oral Pathology 国際会議

Oka H, Maretaningtias DA, Nguyen PT, Kato K, Nikawa H, Sugiyama M, Sugai M .  An assessment of educational program for undergraduate dental students with Japanese-English dual linguistic education system at Hiroshima University (the third and the fourth year) .  The 17th Ottawa Conference  2016年  The University of British Columbia国際会議

Nguyen PT, Miyauchi M, Fujii M .  Interaction between N-cadherin and DcR-2 induces anti-apoptosis through activation of ERK and inhibition of p65 .  The 75th annual meeting of Japanese Cancer Association   2016年  Japanese Cancer Association国際会議

Oka H, Nguyen PT, Kato K .  The current status of instruction and curricular content in forensic odontology in Asian countries. Results from the pilot questionnaire survey .  Annual meeting of South East Asia Association for Dental Education   2015年  招待 国際会議

Oka H, Nguyen PT, Kato K .  Undergraduate forensic dental education in Japan .  The 2nd International Symposium   2015年  招待 国際会議

Oka H, Suardita K, Nguyen PT, Takata T .  Assessment of Japanese-English dual linguistic education system at HUD-Study on the factors students expect for the present lectures / practices .  The 33rd annual academic meeting of Japanese Dental Education Association   2014年  Japanese Dental Education Association

Nguyen PT, Subarnbhesaj A, Miyauchi M, Ogawa I, Takata T .  The FGFR1 inhibitor PD173074 reduces osteoclastognesis in gingival squamous cell carcinoma .  The 17th International Congress on Oral Pathology and Medicine   2014年  International Association of Oral and Maxillofacial Pathologists国際会議

Subarnbhesaj A, Miyauchi M, Inubushi T, Chanbra C, Nguyen PT, Takata T .  Role of VEGF-Flt1- signaling in oral cancer progression. .  The 17th International Congress on Oral Pathology and Medicine   2014年  International Association of Oral and Maxillofacial Pathologists国際会議

Subarnbhesaj A, Miyauchi M, Inubushi T, Chanbra C, Ayuningtyas NF, Nguyen PT, Takata T .  Role of VEGF-Flt-1 signaling in malignant behaviors of oral cancer .  The 30th Meeting of International Academy of Pathology   2014年  International Academy of Pathology国際会議

Mikuriya A, Subarnbhesaj A, Miyauchi M, Nguyen PT, Takata T .  Role of VEGF-Flt-1 signaling in bone invasion of oral cancer. .  The 62nd annual meeting of Japanese association of dental research   2014年  Japanese Association for Dental Research

Sugai M, Oka H, Suardita K, Nguyen PT, Takata T, Kato K, Nikawa H .  Assessment of Japanese-English dual linguistic education system at HUD-Feedbacks from the lecturers about present conditions and handling .  The 33rd Annual Academic Meeting of Japanese Dental Education Association   2014年  Japanese Dental Education Association

Subarnhesaj A, Miyauchi M, Inubushi T, Chanbora C, Nguyen PT, Takata T .  The importance of VEGF-Flt-1 pathway in oral cancer progression .  The 5th Hiroshima Conference on Education and Science in Dentistry  2013年  Hiroshima University国際会議

Nguyen PT, Tsunematsu T, Yanagisawa S, Kudo Y, Miyauchi M, Kamata N, Takata T .  The FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through transcription factor AP-1 .  The 5th Hiroshima Conference on Education and Science in Dentistry   2013年  Hiroshima University国際会議

Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T .  FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through suppression of AP-1 in Head and Neck squamous cell carcinoma .  The 23rd Annual Meeting of the Japanese Society of Oral Pathology   2012年  The Japanese Society of Oral Pathology国際会議

Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T. .  FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through suppression of AP-1 in Head and Neck squamous cell carcinoma .  Mechanism & models of Cancer Meeting   2012年  Cold Spring Harbor Laboratory国際会議

Ohbayashi M, Nguyen PT, Kudo Y, Yoshida M, Miyauchi M, Ogawa I, Takata T .  N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition .  The 15h International Congress on Oral Pathology and Medicine   2010年  International Association of Oral and Maxillofacial Pathologists国際会議

Tomishima A, Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T .  The roles of MCTP2 in oral squamous cell carcinoma .  The 112th annual meeting of The Japanese Society Pathology  2023年4月 

Nguyen PT, Shima K, Sasahira T .  New insights into YAP nuclear translocation to promote liver tumorigenesis .  The 81st annual meeting of Japanese Cancer Association  2022年9月 

Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T .  Impacts of KPNA7 amplification and overexpression on tumor infiltrating immune cells of HNSCCs .  The 112th annual meeting of The Japanese Society Pathology  2023年4月 

Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T .  EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis. .  The 112th annual meeting of The Japanese Society Pathology  2023年4月 

Oku Y, Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T .  Cytoplasmic TCF19 translocation impairs DNA damage repair in HNSCC. .  The 112th annual meeting of The Japanese Society Pathology  2023年4月 

Shima K, Nguyen PT, Shimojukkoku Y, Sasahira T .  Analysis of METTL5 expression and function in oral squamous cell carcinoma. .  The 112th annual meeting of The Japanese Society Pathology  2023年4月 

下拾石 雄大, Phuong Thao NGUYEN, 嶋 香織, 石田喬之, 笹平智則 .  Functional analysis of EGR-1 as a tumor suppressor gene in oral squamous cell carcinoma .  第65回歯科基礎医学会  2023年9月 

Kaori Shima, Phuong Thao Nguyen, Yudai Shimojukkoku, Tomonori Sasahira .  Analysis of METTL5, a m6A methyltransferase, expression in oral squamous cell carcinoma .  第65回歯科基礎医学会  2023年9月 

Thao Nguyen, Kaori Shima, Yudai Shimojukkoku, Yuka Kajiya, Tomonori Sasahira .  Amplication of the nuclear import receptor KPNA7 is associated with poor overall survival in head and neck cancer .  第82回日本癌学会  2023年9月 

胆管癌の新規腫瘍マーカーであるEPS8L3によるYAPの核内移行に関する新展開

2022年12月 - 2025年3月

公益財団法人ヒロセ財団の研究 

NGUYEN THAO

胆管癌の新規腫瘍マーカーであるEPS8L3によるYAPの核内移行に関する新展開

2022年12月 - 2024年12月

公益財団法人ヒロセ財団の研究助成 

EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis

研究課題/領域番号：21K15401  2021年4月 - 2024年3月

Japan Society for the promotion of science  若手研究

NGUYEN THAO

Periodontitis induced alterations of gut microbial metabolite promotes liver cancer through senescence

研究課題/領域番号：19K18963  2019年4月 - 2021年3月

Japan Society for the promotion of science  若手研究

Association of periodontitis and liver diseases

2017年 - 2018年

広島大学 

Study on development of novel therapy targeting N-cadherin for oral cancer

2011年10月 - 2013年10月

Japan Society for the promotion of science