Updated on 2024/10/16

写真a

 
NGUYEN T PHUONG THAO
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Oncology Assistant Professor
Title
Assistant Professor
External link

Degree

  • PhD ( 2011.9 )

  • Doctor of Dental Surgery ( 2006.10 )

Research Interests

  • Oral cancer

  • molecular biology

  • head and neck cancer

  • metabolism

  • liver cancer

  • immune-oncology

  • deep learning

  • oncovirus

  • oral cancer, head and neck cancer, liver cancer, metabolism, immune-oncology

Research Areas

  • Life Science / Cell biology

  • Life Science / Gastroenterology

  • Life Science / Experimental pathology

  • Life Science / Human pathology

  • Life Science / Molecular biology

  • Life Science / Oral pathobiological science

  • Life Science / Tumor biology

  • Life Science / Virology

  • Life Science / Oral pathobiological science

  • Life Science / Oral biological science

  • Life Science / Molecular biology

  • Life Science / Experimental pathology

▼display all

Education

  • University of Medicine and Pharmacy at Ho Chi Minh city   Doctor of Dental Surgery

    2000.9 - 2006.6

      More details

    Country: Viet Nam

  • Hiroshima University   Oral Maxillofacial Pathobiology   PhD

    2008.10 - 2011.9

Research History

  • Kagoshima University   Assistant Professor

    2022.9

  • Kagoshima University   Graduate School of Medical and Dental Sciences   Assistant Professor

    2022.9

  • Hiroshima University   Graduate school of Biomedical Sciences   Researcher

    2021.4 - 2022.8

  • Hiroshima University   Faculty of Dentistry   Researcher

    2021.4 - 2022.8

      More details

    Country:Japan

  • Hiroshima University   Hiroshima University Hospital   Researcher

    2019.1 - 2021.3

  • Hiroshima University   Hiroshima University Hospital   Researcher

    2019.1 - 2021.3

      More details

    Country:Japan

  • Hiroshima University   Graduate school of Biomedical Sciences   Assistant Professor

    2014.1 - 2018.12

  • Hiroshima University   Graduate school of Biomedical Sciences   Researcher

    2011.10 - 2013.10

  • Hiroshima University   Graduate school of Biomedical Sciences   Research Assistant

    2008.10 - 2011.9

  • University of Medicine and Pharmacy at Ho Chi Minh city   Oral Pathology   Lecturer

    2006.10 - 2008.9

      More details

    Country:Viet Nam

▼display all

Committee Memberships

  • The Japanese Society of Pathology   The Japanese Society of Pathology  

    2022.10   

      More details

    Committee type:Academic society

  • The Molecular Biology Society of Japan   The Molecular Biology Society of Japan  

    2020.6   

      More details

    Committee type:Academic society

  • Japanese Cancer Association   Japanese Cancer Association  

    2016.7   

      More details

    Committee type:Academic society

 

Papers

  • Phuong Thao Nguyen, Yudai Shimojukkoku, Yuka Kajiya, Yasunobu Oku, Ayami Tomishima, Kaori Shima, Tomonori Sasahira .  Gene alterations in the nuclear transport receptor superfamily: A study of head and neck cancer .  PLOS ONE19 ( 5 ) e0300446 - e0300446   2024.5

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science (PLoS)  

    In cancer cells, the nuclear transport system is often disrupted, leading to abnormal localization of nuclear proteins and altered gene expression. This disruption can arise from various mechanisms such as mutations in genes that regulate nuclear transport, altered expression of transport proteins, and changes in nuclear envelope structure. Oncogenic protein build-up in the nucleus due to the disturbance in nuclear transport can also boost tumor growth and cell proliferation. In this study, we performed bioinformatic analyses of 23 key nuclear transport receptors using genomic and transcriptomic data from pancancer and head and neck squamous cell carcinoma (HNSCC) datasets from The Cancer Genome Atlas (TCGA) and Cancer Cell Line Encyclopedia and found that the total alteration frequency of 23 nuclear transport receptors in 2691 samples of the PCAWG Consortium was 42.1% and a high levels of genetic alterations was significantly associated with poor overall survival. Amplification was the most common type of genetic alterations, and results in the overexpression of nuclear transport receptors in HNSCC compared to normal tissues. Furthermore, our study revealed that seven out of eight cell cycle genes (CDK1, CDK2, CDK4, CDK6, CCNA1, CCNB1, and CCNE2) were significantly and positively correlated with nuclear transport receptor genes in TCGA pancancer and CCLE datasets. Additionally, functional enrichment analysis showed that nuclear transport receptor genes were mainly enriched in the adhesion junction, cell cycle, ERBB, MAPK, MTOR and WNT signaling pathways.

    DOI: 10.1371/journal.pone.0300446

  • 下拾石 雄大, Nguyen Phuong Thao, 嶋 香織, 石田 喬之, 笹平 智則 .  口腔扁平上皮癌における癌抑制遺伝子としてのEGR-1の機能解析 .  Journal of Oral Biosciences Supplement2023   [P1 - 40]   2023.9口腔扁平上皮癌における癌抑制遺伝子としてのEGR-1の機能解析

     More details

    Language:Japanese   Publisher:(一社)歯科基礎医学会  

  • 嶋 香織, Nguyen Phuong Thao, 下拾石 雄大, 笹平 智則 .  口腔扁平上皮癌におけるm6AメチルトランスフェラーゼMETTL5の発現解析 .  Journal of Oral Biosciences Supplement2023   [P3 - 21]   2023.9口腔扁平上皮癌におけるm6AメチルトランスフェラーゼMETTL5の発現解析

     More details

    Language:Japanese   Publisher:(一社)歯科基礎医学会  

  • 下拾石 雄大, Nguyen Phuong Thao, 嶋 香織, 石田 喬之, 笹平 智則 .  口腔扁平上皮癌における癌抑制遺伝子としてのEGR-1の機能解析 .  Journal of Oral Biosciences Supplement2023   [P1 - 40]   2023.9口腔扁平上皮癌における癌抑制遺伝子としてのEGR-1の機能解析

     More details

    Language:Japanese   Publisher:(一社)歯科基礎医学会  

  • 嶋 香織, Nguyen Phuong Thao, 下拾石 雄大, 笹平 智則 .  口腔扁平上皮癌におけるm6AメチルトランスフェラーゼMETTL5の発現解析 .  Journal of Oral Biosciences Supplement2023   [P3 - 21]   2023.9口腔扁平上皮癌におけるm6AメチルトランスフェラーゼMETTL5の発現解析

     More details

    Language:Japanese   Publisher:(一社)歯科基礎医学会  

  • 奥 康伸, Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則 .  細胞質内のTCF19転座はHNSCCにおけるDNA損傷修復を阻害する(Cytoplasmic TCF19 translocation impairs DNA damage repair in HNSCC) .  日本病理学会会誌112 ( 1 ) 387 - 387   2023.3細胞質内のTCF19転座はHNSCCにおけるDNA損傷修復を阻害する(Cytoplasmic TCF19 translocation impairs DNA damage repair in HNSCC)

     More details

    Language:English   Publisher:(一社)日本病理学会  

  • 冨嶋 彩未, Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則 .  口腔癌におけるMCTP1とMCTP2の機能的な差異についての検討 .  日本病理学会会誌112 ( 1 ) 388 - 388   2023.3口腔癌におけるMCTP1とMCTP2の機能的な差異についての検討

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

  • 嶋 香織, Nguyen Phuong Thao, 下拾石 雄大, 笹平 智則 .  口腔扁平上皮癌におけるMETTL5発現と機能の解析 .  日本病理学会会誌112 ( 1 ) 289 - 290   2023.3口腔扁平上皮癌におけるMETTL5発現と機能の解析

     More details

    Language:Japanese   Publisher:(一社)日本病理学会  

  • Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則 .  KPNA7の増幅および過剰発現がHNSCCの腫瘍浸潤免疫細胞に及ぼす影響(Impacts of KPNA7 amplification and overexpression on tumor infiltrating immune cells of HNSCCs) .  日本病理学会会誌112 ( 1 ) 291 - 291   2023.3KPNA7の増幅および過剰発現がHNSCCの腫瘍浸潤免疫細胞に及ぼす影響(Impacts of KPNA7 amplification and overexpression on tumor infiltrating immune cells of HNSCCs)

     More details

    Language:English   Publisher:(一社)日本病理学会  

  • Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則 .  EPS8L3はYAPの核内移行を仲介し肝腫瘍化を促進する(EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis) .  日本病理学会会誌112 ( 1 ) 295 - 295   2023.3EPS8L3はYAPの核内移行を仲介し肝腫瘍化を促進する(EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis)

     More details

    Language:English   Publisher:(一社)日本病理学会  

  • Hoang Trong Hung, Phuong Thao Nguyen, Nam Cong Nhat Huynh, Tam Thi Thanh Nguyen, Trang Thi Huyen Tu, Michael George Botelho, Lan Van Nguyen, Kaori Shima, Tomonori Sasahira .  Reliability of online dental final exams in the pre and post COVID-19 era: A comparative study .  PLOS ONE   2023 Reliability of online dental final exams in the pre and post COVID-19 era: A comparative studyReviewed International coauthorship

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1371/journal.pone.0286148

    DOI: https://doi.org/10.1371/journal.pone.0286148

  • Kaori Shima, Phuong Thao Nguyen, Yudai Shimojukkoku, Tomonori Sasahira .  Two cases of primordial odontogenic tumor in the maxilla .  Japanese Journal of Diagnostic Pathology40 ( 3 ) 265 - 271   2023Two cases of primordial odontogenic tumor in the maxillaReviewed

     More details

    Language:Japanese   Publishing type:Research paper (other academic)  

  • Kaori Shima, Phuong Thao Nguyen, Yudai Shimojukkoku, Yuka Kajiya, Tomonori Sasahira .  Solitary circumscribed neuroma of the upper lip: A case report .  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2023Solitary circumscribed neuroma of the upper lip: A case report

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.ajoms.2023.11.009

  • Nguyen PT, Kanno K, Pham QT, Kikuchi Y, Kakimoto M, Kobayashi T, Otani Y, Kishikawa N, Miyauchi M, Arihiro K, Ito M, Tazuma S .  Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma .  Journal of Cancer Research and Clinical Oncology146   3255 - 3268   2021Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinomaReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00432-020-03374-9

    DOI: 10.1007/s00432-020-03374-9

  • Kobayashi T, Kanno K, Nguyen PT, Sugiyama A, Kawahara A, Otani Y, Kishikawa N, Ito M, Tazuma S .  Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis .  Journal of Gastroenterology and Hepatology35   2140 - 2150   2020.12Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitisReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.15088

    DOI: 10.1111/jgh.15088

  • Ohigashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Kobayashi T, Matsuo H, Tazuma S .  Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyte .  J Hepatobiliary Pacreat Sci26   568 - 577   2019.12Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyteReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhbp.684

    DOI: 10.1002/jhbp.684

  • Kobayashi T, Kanno K, Nguyen PT, Kishikawa N, Tazuma S .  Molecular mechanism in which periostin induces hepatic steatosis in vivo and in vitro .  Hepatology70   1286 - 1286   2019.5Molecular mechanism in which periostin induces hepatic steatosis in vivo and in vitroReviewed

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

    DOI: 10.1002/hep.3094

    DOI: 10.1002/hep.3094

  • Nguyen PT, Kanno K, Pham T, Kobayashi T, Tazuma S .  Deoxycholic acid-Induced senescent hepatic stellate cell promote malignant behaviors of hepatocellular carcinogenesis .  Gastroenterology156   2019.5Deoxycholic acid-Induced senescent hepatic stellate cell promote malignant behaviors of hepatocellular carcinogenesisReviewed

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (international conference proceedings)  

    DOI: 10.1016/s0016-5085(19)38870-5

    DOI: 10.1016/s0016-5085(19)38870-5

  • Chea C, Miyauchi M, Inubushi T, Okamoto K, Haing S, Nguyen PT, Imanaka H, Takata T .  Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition in oral squamous cell carcinoma .  Biochem Biophys Res Commun502   142 - 147   2018.12Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition in oral squamous cell carcinomaReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2018.10.193

    DOI: 10.1016/j.bbrc.2018.10.193

  • Nguyen PT, Nguyen D, Chea C, Miyauchi M, Fujii M, Takata T .  Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer .  Oncotarget9   31516 - 31530   2018.7Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancerReviewed

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.25846

    DOI: 10.18632/oncotarget.25846

  • Kobayashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Tazuma S .  Periostin Antisense Oligonucleotide Prevents Hepatic Steatosis and Fibrosis in Mice: A novel strategy for Nonalcoholic Steatohepatitis Treatment .  Hepatology68   2018.5Periostin Antisense Oligonucleotide Prevents Hepatic Steatosis and Fibrosis in Mice: A novel strategy for Nonalcoholic Steatohepatitis TreatmentReviewed

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

  • Oka H, Ishida Y, Hong G, Nguyen PT .  Perceptions of dental students in Japanese national universities about studying abroad .  Eur J Dent Educ22   e1 - e6   2018.2Perceptions of dental students in Japanese national universities about studying abroadReviewed International coauthorship

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/eje.12212

    DOI: 10.1111/eje.12212

  • Chea C, Miyauchi M, Inubushi T, N, Subarnbhesaj A, Nguyen PT, Shestha M, Haing S, Ohta K, Takata T .  Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma .  PLOS ONE13   e0191683   2018.1Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinomaReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0191683

    DOI: 10.1371/journal.pone.0191683

  • Subarnbhesaj A, Miyauchi M, Mikuriya A, Nguyen PT, Chanbora C, Ayunintyas NF, Fujita M, Niida S, Takata T .  Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma .  PLOS ONE12   e0187092   2017.11Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinomaReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0187092

    DOI: 10.1371/journal.pone.0187092

  • Subarnbhesaj A, Miyauchi M, Chea C, Nurina FA, Nguyen PT, Takata T .  Role of VEGF-Flt-1 Signaling in Oral Cancer Progression .  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology119   136 - 137   2015.3Role of VEGF-Flt-1 Signaling in Oral Cancer ProgressionReviewed

     More details

    Language:English   Publishing type:Research paper (international conference proceedings)  

    DOI: 10.1016/j.oooo.2014.07.149

    DOI: 10.1016/j.oooo.2014.07.149

  • Nguyen PT, Subarnbhesaj A, Miyauchi M, Ogawa I, Takata T .  The FGFR1 inhibitor PD173074 reduces osteoclastogenesis in gingival squamous cell carcinoma .  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology119   172 - 172   2015.3The FGFR1 inhibitor PD173074 reduces osteoclastogenesis in gingival squamous cell carcinomaReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (international conference proceedings)  

    DOI: 10.1016/j.oooo.2014.07.309

    DOI: 10.1016/j.oooo.2014.07.309

  • Nguyen PT, Tsunematsu T, Yanagisawa S, Kudo Y, Miyauchi M, Kamata N, Takata T .  The FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP- 1 .  British Journal Cancer109   2248 - 2258   2013.10The FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP- 1Reviewed

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bjc.2013.550

    DOI: 10.1038/bjc.2013.550

  • Yasusei Kudo , Shinji Iizuka, Maki Yoshida, Phuong Thao Nguyen, Samadarani B S M Siriwardena, Takaaki Tsunematsu, Mariko Ohbayashi, Toshinori Ando, Daijiro Hatakeyama, Toshiyuki Shibata, Keiichi Koizumi, Masahiro Maeda, Naozumi Ishimaru, Ikuko Ogawa, Takashi Takata .  Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer .  PLOS ONE7   1 - 14   2012.8Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck CancerReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0044488

    DOI: 10.1371/journal.pone.0044488

  • Nguyen PT, Kudo Y, Yoshida M, Takata T .  N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial- mesenchymal transition .  Histol Histopathol 26   147 - 156   2011.2N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial- mesenchymal transitionReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.14670/HH-26.147

    DOI: 10.14670/HH-26.147

  • Nguyen PT, Kudo Y, Yoshida M, Iizuka S, Ogawa I, Takata T .  N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region .  Journal of Oral Pathology and Medicine 40   77 - 82   2011.1N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck regionReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-0714.2010.00966.x

    DOI: 10.1111/j.1600-0714.2010.00966.x

  • SL Priebe, J Aleksejūnienė, C Zed, S Dharamsi, DHQ Thinh, NT Hong, TTK Cuc, Nguyen PT .  Oral squamous cell carcinoma and cultural oral risk habits in Vietnam .  International Journal of Dental Hygiene8   159 - 168   2010.8Oral squamous cell carcinoma and cultural oral risk habits in VietnamReviewed International coauthorship

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1601-5037.2010.00461.x

    DOI: 10.1111/j.1601-5037.2010.00461.x

▼display all

Presentations

  • Tahara M, Nguyen PT, Shimojukkoku Y, Sasahira T   Overexpression of KPNA7 is associated with poor overall survival in head and neck cancer  

    The 113th annual meeting of The Japanese Society Pathology  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Poster presentation  

  • Nguyen PT, Kajiya Y, Shimojukokku Y, Sasahira T   Accumulation of lipid droplets induces the growth of OSCC in a SCARB1-dependent manner  

    The 113th annual meeting of The Japanese Society Pathology  2024.3 

     More details

    Event date: 2024.3

    Language:English   Presentation type:Poster presentation  

  • Naoyama S, Nguyen PT, Tahara M, Shimojukkoku Y, Kajiya Y, Sasahira T   Novel perspectives on the infiltration of immune cells in head and neck cancer  

    The 113th annual meeting of The Japanese Society Pathology  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Poster presentation  

  • Nguyen PT, Kajiya Y, Shimojukkoku Y, Sasahira T   New insights into YAP nuclear translocation in liver tumorigenesis  

    The 113th annual meeting of The Japanese Society Pathology  2024.3 

     More details

    Event date: 2024.3

    Language:English   Presentation type:Poster presentation  

  • Onishi M, Nguyen PT, Kamenosono T, Nguyen PA, Shimojukkoku Y, Kajiya Y, Sasahira T   Digital CD8+ lymphocyte density predicts overall survival of head and neck squamous cell carcinoma  

    The 113th annual meeting of The Japanese Society Pathology  2024.3 

     More details

    Event date: 2024.3

    Language:Japanese   Presentation type:Poster presentation  

  • Yudai Shimojukkoku, Phuong Thao Nguyen, Kaori Shima, Takayuki Ishida, Tomonori Sasahira   Functional analysis of EGR-1 as a tumor suppressor gene in oral squamous cell carcinoma  

    The 65th Annual meeting of The Society of Basic Dental Medicine  2023.9  The Society of Basic Dental Medicine

     More details

    Event date: 2023.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Tokyo   Country:Japan  

  • Phuong Thao Nguyen, Kaori Shima, Yudai Shimojukkoku, Yuka Kajiya, Tomonori Sasahira   Amplication of the nuclear import receptor KPNA7 is associated with poor overall survival in head and neck cancer  

    The 82th Annual Meeting of The Japanese Cancer Association  2023.9  The Japanese Cancer Association

     More details

    Event date: 2023.9

    Language:English   Presentation type:Poster presentation  

    Venue:Yokohama   Country:Japan  

  • Kaori Shima, Phuong Thao Nguyen, Yudai Shimojukkoku, Tomonori Sasahira   Analysis of METTL5, a m6A methyltransferase, expression in oral squamous cell carcinoma  

    The 65th Annual Meeting of The Society of Basic Dental Medicine  2023.9  The Society of Basic Dental Medicine

     More details

    Event date: 2023.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Tokyo   Country:Japan  

  • Shima K, Nguyen PT, Shimojukkoku Y, Sasahira T   Analysis of METTL5 expression and function in oral squamous cell carcinoma.  

    The 112th annual meeting of The Japanese Society Pathology   2023.4  The Japanese Society Pathology

     More details

    Event date: 2023.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Yamaguchi   Country:Japan  

  • Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T   Impacts of KPNA7 amplification and overexpression on tumor infiltrating immune cells of HNSCCs  

    The 112th annual meeting of The Japanese Society Pathology   2023.4  The Japanese Society Pathology

     More details

    Event date: 2023.4

    Language:English   Presentation type:Poster presentation  

    Venue:Yamaguchi   Country:Japan  

  • Tomishima A, Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T   The roles of MCTP2 in oral squamous cell carcinoma.  

    The 112th annual meeting of The Japanese Society Pathology   2023.4  The Japanese Society Pathology

     More details

    Event date: 2023.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Yamaguchi   Country:Japan  

  • Oku Y, Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T   Cytoplasmic TCF19 translocation impairs DNA damage repair in HNSCC.  

    The 112th annual meeting of The Japanese Society Pathology   2023.4  The Japanese Society Pathology

     More details

    Event date: 2023.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Yamaguchi   Country:Japan  

  • Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T.   EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis.  

    The 112th annual meeting of The Japanese Society Pathology   2023.4  The Japanese Society Pathology

     More details

    Event date: 2023.4

    Language:English   Presentation type:Poster presentation  

    Venue:Yamaguchi   Country:Japan  

  • Nguyen PT, Shima K, Sasahira T   New insights into YAP nuclear translocation to promote liver tumorigenesis   International conference

    The 81st annual meeting of Japanese Cancer Association   2022.9  Japanese Cancer Association

     More details

    Event date: 2022.9

    Language:English   Presentation type:Poster presentation  

    Venue:Yokohama   Country:Japan  

  • Nguyen PT, Kanno K, Pham QT, Kobayashi T, Miyauchi M, Arihiro K, Tazuma S, Ito M   Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma   International conference

    The 43rd annual meeting of The molecular Biology Society in Japan  2020  The molecular Biology Society in Japan

     More details

    Event date: 2020

  • Nguyen PT, Tazuma S, Otani Y, Ito M   Contributions of hepatic stellate cells into hepatocellular carcinoma   International conference

    The 79th annual meeting of Japanese Cancer Association  2020  Japanese Cancer Association

     More details

    Event date: 2020

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  • Juraev J, Matsumoto M, Kanno K, Nguyen PT, Tazuma S   Geographic distribution of X-Ray, CT and MRI devices: a comparison between Japan and Uzbekistan   International conference

    Wonca  2019  World Organization of Family Doctors

     More details

    Event date: 2019

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto   Country:Japan  

  • Nguyen PT, Kanno K, Pham QT, Kobayashi T, Tazuma S.   Deoxycholic acid-induced senescent hepatic stellate cells generate inflammatory tumor microenvironment that drives progression in hepatocellular carcinoma  

    The 41st Bile acid meeting   2019 

     More details

    Event date: 2019

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Tokyo   Country:Japan  

  • Kobayashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Tazuma S   Molecular mechanism in which periostin induces hepatic steatosis in vivo and in vitro   International conference

    71st Annual Meeting of American Association for the Study of Liver Disease   2019  American Association for the study of liver diseases

     More details

    Event date: 2019

    Language:English   Presentation type:Poster presentation  

    Venue:Boston   Country:United States  

  • Nguyen PT, Kanno K, Pham T, Kobayashi T, Kishikawa N, Otani Y, Tazuma S   Deoxycholic acid-Induced senescent hepatic stellate cell promote malignant behaviors of hepatocellular carcinogenesis: Implication to Underlying Mechanisms of Metabolic Syndrome-Based Fatty liver and carcinogenesis   International conference

    120th Annual Meeting of American Gastroenterological Association   2019  American Gastroenterological Association

     More details

    Event date: 2019

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego   Country:United States  

  • Nguyen PT, Kanno K, Pham T, Kobayashi T, Tazuma S   Deoxycholic acid-induced senescent hepatic stellate cells promote invasion and metastasis of hepatocellular carcinoma cells  

    The 40th Bile acid meeting  2018  Japanese Bile Acid Association

     More details

    Event date: 2018

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Hiroshima   Country:Japan  

  • Ohigashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Kobayashi T, Matsuo H, Tazuma S   Protective effect of phosphatidylcholine on lypophosphatidylcholine-induced cellular senescence in cholangiocyte  

    The 40th Bile acid meeting   2018 

     More details

    Event date: 2018

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Tokyo   Country:Japan  

  • Nguyen PT, Miyauchi M, Fujii M   The role of molecular triad PlGF/ Flt1/ MMP1 in bone invasion of gingival squamous cell carcinoma.   International conference

    The 76th annual meeting of Japanese Cancer Association   2017  Japanese Cancer Asssociation

     More details

    Event date: 2017

    Language:English   Presentation type:Poster presentation  

    Venue:Yokohama  

  • Kobayashi T, Kanno K, Sugiyama A, Nguyen PT, Kishikawa N, Otani Y, Tazuma S   Periostin Antisense Oligonucleotide Prevents Hepatic Steatosis and Fibrosis in Mice: A novel strategy for Nonalcoholic Steatohepatitis Treatment   International conference

    70th Annual Meeting of American Association for the Study of Liver Disease   2017  American Association for the study of liver diseases

     More details

    Event date: 2017

    Language:English   Presentation type:Poster presentation  

    Venue:Boston   Country:United States  

  • Nguyen PT, Nguyen D, Miyauchi M, Fujii M, Takata T.   Overexpression of N-cadherin induces anti-apoptosis effects on cancer cells through TRAIL receptors and caspase pathway   International conference

    The 27th Annual Meeting of the Japanese Society of Oral Pathology  2016  the Japanese Society of Oral Pathology

     More details

    Event date: 2016

    Language:English   Presentation type:Poster presentation  

    Venue:Hiroshima   Country:Japan  

  • Oka H, Maretaningtias DA, Nguyen PT, Kato K, Nikawa H, Sugiyama M, Sugai M   An assessment of educational program for undergraduate dental students with Japanese-English dual linguistic education system at Hiroshima University (the third and the fourth year)   International conference

    The 17th Ottawa Conference  2016  The University of British Columbia

     More details

    Event date: 2016

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Vancouver   Country:Canada  

  • Nguyen PT, Miyauchi M, Fujii M   Interaction between N-cadherin and DcR-2 induces anti-apoptosis through activation of ERK and inhibition of p65   International conference

    The 75th annual meeting of Japanese Cancer Association   2016  Japanese Cancer Association

     More details

    Event date: 2016

    Language:English   Presentation type:Poster presentation  

    Venue:Yokohama   Country:Japan  

  • Oka H, Nguyen PT, Kato K   The current status of instruction and curricular content in forensic odontology in Asian countries. Results from the pilot questionnaire survey   Invited International conference

    Annual meeting of South East Asia Association for Dental Education   2015 

     More details

    Event date: 2015

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Bali   Country:Indonesia  

  • Oka H, Nguyen PT, Kato K   Undergraduate forensic dental education in Japan   Invited International conference

    The 2nd International Symposium   2015 

     More details

    Event date: 2015

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Surabaya   Country:Indonesia  

  • Oka H, Suardita K, Nguyen PT, Takata T   Assessment of Japanese-English dual linguistic education system at HUD-Study on the factors students expect for the present lectures / practices  

    The 33rd annual academic meeting of Japanese Dental Education Association   2014  Japanese Dental Education Association

     More details

    Event date: 2014

    Language:English   Presentation type:Poster presentation  

    Venue:Kitakyushu   Country:Japan  

  • Nguyen PT, Subarnbhesaj A, Miyauchi M, Ogawa I, Takata T   The FGFR1 inhibitor PD173074 reduces osteoclastognesis in gingival squamous cell carcinoma   International conference

    The 17th International Congress on Oral Pathology and Medicine   2014  International Association of Oral and Maxillofacial Pathologists

     More details

    Event date: 2014

    Language:English   Presentation type:Poster presentation  

    Venue:Istanbul   Country:Turkey  

  • Subarnbhesaj A, Miyauchi M, Inubushi T, Chanbra C, Nguyen PT, Takata T   Role of VEGF-Flt1- signaling in oral cancer progression.   International conference

    The 17th International Congress on Oral Pathology and Medicine   2014  International Association of Oral and Maxillofacial Pathologists

     More details

    Event date: 2014

    Language:English   Presentation type:Poster presentation  

    Venue:Istanbul   Country:Turkey  

  • Subarnbhesaj A, Miyauchi M, Inubushi T, Chanbra C, Ayuningtyas NF, Nguyen PT, Takata T   Role of VEGF-Flt-1 signaling in malignant behaviors of oral cancer   International conference

    The 30th Meeting of International Academy of Pathology   2014  International Academy of Pathology

     More details

    Event date: 2014

    Language:English   Presentation type:Poster presentation  

    Venue:Bangkok   Country:Thailand  

  • Mikuriya A, Subarnbhesaj A, Miyauchi M, Nguyen PT, Takata T   Role of VEGF-Flt-1 signaling in bone invasion of oral cancer.  

    The 62nd annual meeting of Japanese association of dental research   2014  Japanese Association for Dental Research

     More details

    Event date: 2014

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Osaka   Country:Japan  

  • Sugai M, Oka H, Suardita K, Nguyen PT, Takata T, Kato K, Nikawa H   Assessment of Japanese-English dual linguistic education system at HUD-Feedbacks from the lecturers about present conditions and handling  

    The 33rd Annual Academic Meeting of Japanese Dental Education Association   2014  Japanese Dental Education Association

     More details

    Event date: 2014

    Language:English   Presentation type:Poster presentation  

    Venue:Kitakyuyshu   Country:Japan  

  • Subarnhesaj A, Miyauchi M, Inubushi T, Chanbora C, Nguyen PT, Takata T   The importance of VEGF-Flt-1 pathway in oral cancer progression   International conference

    The 5th Hiroshima Conference on Education and Science in Dentistry  2013  Hiroshima University

     More details

    Event date: 2013

    Language:English   Presentation type:Poster presentation  

    Venue:Hiroshima   Country:Japan  

  • Nguyen PT, Tsunematsu T, Yanagisawa S, Kudo Y, Miyauchi M, Kamata N, Takata T   The FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through transcription factor AP-1   International conference

    The 5th Hiroshima Conference on Education and Science in Dentistry   2013  Hiroshima University

     More details

    Event date: 2013

    Language:English   Presentation type:Poster presentation  

    Venue:Hiroshima   Country:Japan  

  • Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T   FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through suppression of AP-1 in Head and Neck squamous cell carcinoma   International conference

    The 23rd Annual Meeting of the Japanese Society of Oral Pathology   2012  The Japanese Society of Oral Pathology

     More details

    Event date: 2012

    Language:English   Presentation type:Poster presentation  

    Venue:Fukuoka   Country:Japan  

  • Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T.   FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial transition through suppression of AP-1 in Head and Neck squamous cell carcinoma   International conference

    Mechanism & models of Cancer Meeting   2012  Cold Spring Harbor Laboratory

     More details

    Event date: 2012

    Language:English   Presentation type:Poster presentation  

    Venue:New York   Country:United States  

  • Ohbayashi M, Nguyen PT, Kudo Y, Yoshida M, Miyauchi M, Ogawa I, Takata T   N-cadherin expression is involved in malignant behavior of head and neck cancer in relation to epithelial-mesenchymal transition   International conference

    The 15h International Congress on Oral Pathology and Medicine   2010  International Association of Oral and Maxillofacial Pathologists

     More details

    Event date: 2010

    Language:English   Presentation type:Poster presentation  

    Venue:Korea   Country:Korea, Democratic People's Republic of  

  • Tomishima A, Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T   The roles of MCTP2 in oral squamous cell carcinoma  

    The 112th annual meeting of The Japanese Society Pathology  2023.4 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • Nguyen PT, Shima K, Sasahira T   New insights into YAP nuclear translocation to promote liver tumorigenesis  

    The 81st annual meeting of Japanese Cancer Association  2022.9 

     More details

    Language:English   Presentation type:Poster presentation  

  • Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T   Impacts of KPNA7 amplification and overexpression on tumor infiltrating immune cells of HNSCCs  

    The 112th annual meeting of The Japanese Society Pathology  2023.4 

     More details

    Language:English   Presentation type:Poster presentation  

  • Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T   EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis.  

    The 112th annual meeting of The Japanese Society Pathology  2023.4 

     More details

    Presentation type:Poster presentation  

  • Oku Y, Nguyen PT, Shima K, Shimojukkoku Y, Sasahira T   Cytoplasmic TCF19 translocation impairs DNA damage repair in HNSCC.  

    The 112th annual meeting of The Japanese Society Pathology  2023.4 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • Shima K, Nguyen PT, Shimojukkoku Y, Sasahira T   Analysis of METTL5 expression and function in oral squamous cell carcinoma.  

    The 112th annual meeting of The Japanese Society Pathology  2023.4 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • 下拾石 雄大, Phuong Thao NGUYEN, 嶋 香織, 石田喬之, 笹平智則   Functional analysis of EGR-1 as a tumor suppressor gene in oral squamous cell carcinoma  

    第65回歯科基礎医学会  2023.9 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • Kaori Shima, Phuong Thao Nguyen, Yudai Shimojukkoku, Tomonori Sasahira   Analysis of METTL5, a m6A methyltransferase, expression in oral squamous cell carcinoma  

    第65回歯科基礎医学会  2023.9 

     More details

    Language:Japanese   Presentation type:Poster presentation  

  • Thao Nguyen, Kaori Shima, Yudai Shimojukkoku, Yuka Kajiya, Tomonori Sasahira   Amplication of the nuclear import receptor KPNA7 is associated with poor overall survival in head and neck cancer  

    第82回日本癌学会  2023.9 

     More details

    Language:English   Presentation type:Poster presentation  

▼display all

Awards

  • Research professor/research associate professor system

    2024.1   Kagoshima University   Research Associate Professor

Research Projects

  • Develop the novel targets and immunotherapy-combination agents through targeting nuclear transport receptor

    Grant number:24K13116  2024.4 - 2027.3

    NGUYEN THAO

      More details

    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

  • Development of an immune therapy and monitoring system for head and neck cancer targeting KPN7A as a molecular target

    Grant number:14-002-154  2024.4 - 2025.3

    公益財団法人 高橋産業経済研究財団 

    NGUYEN THAO

      More details

    Authorship:Principal investigator 

  • A deep learning for prediction of prognosis and therapy response in head and neck cancers though multi-staining.

    2023.10 - 2024.3

    KAGOSHIMA UNIVERSITY  Kagoshima University International Joint Research Promotion Project 

    NGUYEN THAO

      More details

    Authorship:Principal investigator 

  • Grant-in-aid for Research Professor and Associate Professor

    2023 - 2024

    Kagoshima University 

    NGUYEN THAO

      More details

    Authorship:Principal investigator 

  • Grant-in-aid for Scientific Research

    2023 - 2024

    Kagoshima University 

    NGUYEN THAO

      More details

    Authorship:Principal investigator 

  • 胆管癌の新規腫瘍マーカーであるEPS8L3によるYAPの核内移行に関する新展開

    2022.12 - 2025.3

    公益財団法人ヒロセ財団の研究 

    NGUYEN THAO

      More details

    Authorship:Principal investigator 

  • 胆管癌の新規腫瘍マーカーであるEPS8L3によるYAPの核内移行に関する新展開

    2022.12 - 2024.12

    公益財団法人ヒロセ財団の研究助成 

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3500000 ( Direct Cost: \3500000 )

  • EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis

    Grant number:21K15401  2021.4 - 2024.3

    Japan Society for the promotion of science  Grants-in-Aid for Scientific Research  Early Career Research

    NGUYEN THAO

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  • Periodontitis induced alterations of gut microbial metabolite promotes liver cancer through senescence

    Grant number:19K18963  2019.4 - 2021.3

    Japan Society for the promotion of science  Grants-in-Aid for Scientific Research  Early Career Research

    NGUYEN THAO

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    This study aimed to examine the effect of DCA on hepatic stellate cells (HSCs), a major component of nonparenchymal cells in the liver, and its subsequent indirect effect on HCC cells. LX2 cells, a human HSC line, were treated with DCA in vitro. Then, HuH7 cells, a human hepatoma cell line, were incubated in conditioned media of DCA-treated LX2 to investigate the subsequent effect focusing on malignant behaviors. DCA resulted in cellular senescence in LX2 with the decreased cell proliferation via cell cycle and the induction of senescence-associated secretory phenotype (SASP) factors. HCC cells were treated with DCA treated LX2-conditioned media, that promoted cell migration and invasion via induction of epithelial mesenchymal transition. These changes were attenuated in the presence of neutralizing antibody against IL8 or TGFb. Pathological analysis of surgical specimens from HCC patients revealed that senescent HSCs were detected in the stroma surrounding HCC.

  • Association of periodontitis and liver diseases

    2017 - 2018

    Hiroshima University 

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000 ( Direct Cost: \700000 、 Indirect Cost:\300000 )

  • Study on development of novel therapy targeting N-cadherin for oral cancer

    2011.10 - 2013.10

    Japan Society for the promotion of science 

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000 ( Direct Cost: \2000000 )

▼display all

 

Teaching Experience

  • Research practice

    2022
    Institution:Kagoshima University

  • Oral pathology

    2022
    Institution:Kagoshima University

  • Dental International cooperation

    2022
    Institution:Kagoshima University

  • Bacteriology, virus, fungi & Immunology

    2021
    -
    2023
    Institution:Van Lang University

  • Oral Biology & Histology

    2021
    -
    2023
    Institution:Van Lang University