Updated on 2022/11/02

写真a

 
FURUSHIMA Daisuke
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine Associate Professor
Title
Associate Professor

Degree

  • 修士(保健学) ( 2008.3   大阪大学 )

  • 博士(保健学) ( 2018.3   大阪大学 )

Education

  • Hiroshima University

    2002.4 - 2006.3

  • Osaka University

    2006.4 - 2008.3

  • Osaka University

    2015.4 - 2018.3

Research History

  • Kagoshima University   Associate Professor

    2022.4

  • University of Shizuoka   School of Pharmaceutical Sciences

    2022.4

  • University of Shizuoka   Lecturer

    2021.4 - 2022.3

  • 静岡県立病院機構   客員研究員

    2018.4 - 2022.3

  • University of Shizuoka   Assistant Professor

    2018.4 - 2021.3

  • University of Shizuoka   Researcher

    2017.9 - 2018.3

  • Osaka University   Researcher

    2014.11 - 2017.8

  • Saga University   Assistant Professor

    2014.4 - 2010.10

  • Tokyo Women's Medical University   Assistant Professor

    2011.4 - 2014.3

  • 埼玉県保健医療部   疾病対策課   職員(医療系)   技師

    2008.4 - 2011.3

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Professional Memberships

  • 日本栄養食糧学会

  • THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

  • JAPAN EPIDEMIOLOGICAL ASSOCIATION

  • 日本医薬品情報学会

Committee Memberships

  • 国立研究開発法人医薬基盤・健康・栄養研究所   セカンドオピニオン事業 査読委員  

    2019.6   

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    Committee type:Other

  • 第4回日本臨床薬理学会東海北陸地方会   事務局  

    2018.7 - 2019.6   

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    Committee type:Academic society

 

Papers

  • Keiko Unno, Daisuke Furushima, Yuya Tanaka, Takeichiro Tominaga, Hirotomo Nakamura, Hiroshi Yamada, Kyoko Taguchi, Toshinao Goda, Yoriyuki Nakamura .  Improvement of Depressed Mood with Green Tea Intake .  Nutrients14 ( 14 ) 2949 - 2949   2022.7

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    Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    Being in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on the biological stress response and inflammation in the brain. Regarding the stress reduction effect of green tea, we found that the sum of caffeine (C) and epigallocatechin gallate (E) relative to the sum of theanine (T) and arginine (A), the major components of green tea, or the CE/TA ratio, is important. The results showed that depression-like behavior, adrenal hypertrophy as a typical stress response, and brain inflammation were suppressed in mice fed green tea components with CE/TA ratios of 2 to 8. In addition, the expression of Npas4, which is reduced in anxiety and depression, was maintained at the same level as controls in mice that consumed green tea with a CE/TA ratio of 4. In clinical human trials, the consumption of green tea with CE/TA ratios of 3.9 and 4.7 reduced susceptibility to subjective depression. These results suggest that the daily consumption of green tea with a CE/TA ratio of 4–5 is beneficial to improving depressed mood.

    DOI: 10.3390/nu14142949

  • NAKAMURA Hirotomo, FURUSHIMA Daisuke, MAKINOSE Shohei, UMEGAKI Keizo, ASAKURA Keiko, KAMIMURA Yuko, CHIBA Tsuyoshi, YAMADA Hiroshi .  Feasibility Study of a Standardized Reporting Format for Adverse Events Associated with Health Food Consumption by Health Food Manufacturers and Sellers .  Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics53 ( 3 ) 57 - 65   2022.5Feasibility Study of a Standardized Reporting Format for Adverse Events Associated with Health Food Consumption by Health Food Manufacturers and Sellers

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    Language:Japanese   Publisher:The Japanese Society of Clinical Pharmacology and Therapeutics  

    DOI: 10.3999/jscpt.53.3_57

  • Takeichiro Tominaga, Daisuke Furushima, Keiko Unno, Ibuki Sugiyama, Makoto Ozeki, Yoriyuki Nakamura, Hiroshi Yamada .  An Exploratory Evaluation of a Low Dose Theanine Consumption on Improving Sleep in Middle-Aged and Older Males .  Food Science & Nutrition Research5 ( 1 ) 1 - 7   2022.1An Exploratory Evaluation of a Low Dose Theanine Consumption on Improving Sleep in Middle-Aged and Older MalesReviewed

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  • Daisuke Furushima, Ibuki Sugiyama, Yuzuki Nomura, Keiko Unno, Hiroshi Yamada .  Effect of combined ingestion of L-theanine and L-arginine for short-term psychological stress in young adults: A randomized placebo-controlled study. .  Journal of Nutritional Science and Vitaminology (in press)   2022Effect of combined ingestion of L-theanine and L-arginine for short-term psychological stress in young adults: A randomized placebo-controlled study.Reviewed

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  • Mai Umeda, Takeichiro Tominaga, Kazuya Kozuma, Hidefumi Kitazawa, Daisuke Furushima, Masanobu Hibi, Hiroshi Yamada .  Preventive effects of tea and tea catechins against influenza and acute upper respiratory tract infections: a systematic review and meta-analysis. .  European journal of nutrition60 ( 8 ) 4189 - 4202   2021.9Preventive effects of tea and tea catechins against influenza and acute upper respiratory tract infections: a systematic review and meta-analysis.Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: Gargling with tea has protective effects against influenza infection and upper respiratory tract infection (URTI). To evaluate if tea and tea catechin consumption has the same protective effects as gargling with tea, we performed a systematic review and meta-analysis. METHODS: We performed a comprehensive literature search using the PubMed, Cochrane Library, Web of Science, and Ichu-shi Web databases. The search provided six randomized controlled trials (RCTs) and four prospective cohort studies (n = 3748). The quality of each trial or study was evaluated according to the Cochrane risk-of-bias tool or Newcastle-Ottawa Scale. We collected data from publications meeting the search criteria and conducted a meta-analysis of the effect of tea gargling and tea catechin consumption for preventing URTI using a random effects model. RESULTS: Tea gargling and tea catechin consumption had significant preventive effects against URTI (risk ratio [RR] = 0.74, 95% confidence interval [CI] 0.64-0.87). In sub-analyses, a significant preventive effect was observed by study type (prospective cohort study: RR = 0.67, 95% CI 0.50-0.91; RCT: RR = 0.79, 95% CI 0.66-0.94) and disease type (influenza: RR = 0.69, 95% CI 0.58-0.84; acute URTI: RR = 0.78, 95% CI 0.62-0.98). Both gargling with tea and consuming tea catechins effectively protected against URTI (tea and tea catechins consumption: RR = 0.68, 95% CI 0.52-0.87; tea gargling: RR = 0.83, 95% CI 0.72-0.96). CONCLUSION: Our findings suggest that tea gargling and tea catechin consumption may have preventive effects against influenza infection and URTI. The potential effectiveness of these actions as non-pharmaceutical interventions, however, requires further investigation.

    DOI: 10.1007/s00394-021-02681-2

    PubMed

  • Daisuke Furushima, Yu Otake, Natsumi Koike, Shintaro Onishi, Takuya Mori, Noriyasu Ota, Hiroshi Yamada .  Investigation of the Oral Retention of Tea Catechins in Humans: An Exploratory Interventional Study. .  Nutrients13 ( 9 ) 3024   2021.8Investigation of the Oral Retention of Tea Catechins in Humans: An Exploratory Interventional Study.Reviewed International journal

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    Green tea catechin ingestion or gargling exhibit anti-viral activity against upper respiratory infection. We hypothesized that retention in the oral cavity could improve the anti-viral effects of catechins. The present study investigated the oral retention of catechins in humans and the effect of catechin beverage viscosity on oral retention. Two intervention studies with different test beverages, beverage-C (40 mL, containing 73.4 mg of catechins) and beverage-XT (40 mL, beverage-C containing 100 mg xanthan gum) were conducted in 20 healthy volunteers (mean age 38.7 years). Catechin concentrations were measured in buccal mucosa samples collected at 10 min, 40 min, and 60 min after ingesting test beverages, and the catechin variability of the tissue after intake was compared between test beverages. As a result, the mean (SEM) concentrations of EGCG were 99.9 (27.2), 58.2 (16.6), and 22.3 (5.7) ng/mg-mucosa at 10, 40, and 60 min, respectively, after ingestion of beverage-XT. Similarly, the catechin concentrations were 86.1 (20.3), 32.2 (5.3), and 27.8 (5.9) ng/mg-mucosa after ingestion of beverage-C. The total retention volume over 60 min tended to be slightly higher after ingestion of beverage-XT, though the difference was not statistically significant. Additional studies are needed to confirm the effect of xanthan gum on improving oral retention of catechins.

    DOI: 10.3390/nu13093024

    PubMed

  • Gaowa Bai, Daisuke Furushima, Toshiro Niki, Takashi Matsuba, Yosuke Maeda, Atsushi Takahashi, Toshio Hattori, Yugo Ashino .  High levels of the cleaved form of galectin-9 and osteopontin in the plasma are associated with inflammatory markers that reflect the severity of covid-19 pneumonia .  International Journal of Molecular Sciences22 ( 9 )   2021.5High levels of the cleaved form of galectin-9 and osteopontin in the plasma are associated with inflammatory markers that reflect the severity of covid-19 pneumoniaReviewed

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    Numbers of patients with coronavirus disease 2019 (COVID-19) have increased rapidly worldwide. Plasma levels of full-length galectin-9 (FL-Gal9) and osteopontin (FL-OPN) as well as their truncated forms (Tr-Gal9, Ud-OPN, respectively), are representative inflammatory biomarkers. Here, we measured FL-Gal9, FL-OPN, Tr-Gal9, and Ud-OPN in 94 plasma samples obtained from 23 COVID-19-infected patients with mild clinical symptoms (CV), 25 COVID-19 patients associated with pneumonia (CP), and 14 patients with bacterial infection (ID). The four proteins were significantly elevated in the CP group when compared with healthy individuals. ROC analysis between the CV and CP groups showed that C-reactive protein had the highest ability to differen-tiate, followed by Tr-Gal9 and ferritin. Spearman’s correlation analysis showed that Tr-Gal9 and Ud-OPN but not FL-Gal9 and FL-OPN, had a significant association with laboratory markers for lung function, inflammation, coagulopathy, and kidney function in CP patients. CP patients treated with tocilizumab had reduced levels of FL-Gal9, Tr-Gal9, and Ud-OPN. It was suggested that OPN is cleaved by interleukin-6-dependent proteases. These findings suggest that the cleaved forms of OPN and galectin-9 can be used to monitor the severity of pathological inflammation and the therapeutic effects of tocilizumab in CP patients.

    DOI: 10.3390/ijms22094978

    Scopus

  • 牧之瀬翔平, 古島大資, 中村洸友, 梅垣敬三, 朝倉敬子, 神村裕子, 天野進吾, 千葉剛, 山田浩 .  Development of a Standardized Reporting Format for Adverse Events Associated with Health Food Consumption and the Evaluation of its Feasibility by Medical Staff .  臨床薬理52 ( 3 ) 55 - 61   2021.5Reviewed

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    Language:Japanese  

    J-GLOBAL

  • Daisuke Furushima, Yuri Takashima, Toshiji Miyagawa, Hiroshi Fujita, Yuzuki Nomura, Koichi Suzuki, Hiroshi Yamada .  Effect of the Fungus Isaria japonica from the Silkworm on Cognitive Function in Older Adults with Mild Cognitive Decline: A Pilot Study .  CURRENT TOPICS IN NUTRACEUTICAL RESEARCH19 ( 4 ) 383 - 387   2021.4Effect of the Fungus Isaria japonica from the Silkworm on Cognitive Function in Older Adults with Mild Cognitive Decline: A Pilot StudyReviewed

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:NEW CENTURY HEALTH PUBLISHERS, LLC  

    Several in vivo studies report that the fungus Isaria japonica grown on silkworm pupae, classified as a Cordycipitaceae, plays a role in preventing memory deficits and may have a protective role against cognitive impairment. The present study investigated the cognitive effects and safety of I. japonica in older adults with mild cognitive decline. Intervention trial was conducted in subjects over 60 years of age with mild cognitive decline (Mini-Mental State Examination [MMSE] score: 20-27). The subjects consumed the I. japonica supplements twice per day for 12 weeks. The outcome measures included the MMSE score and blood test values before and after the intervention. A total of 25 subjects (aged 64-94 years) were eligible for the study. After the intervention, the MMSE score (mean +/- standard deviation) significantly increased from 25.5 +/- 1.6 to 27.1 +/- 2.4 (P < 0.0001). The blood test revealed no change in any of the hematological and biochemical parameters evaluated. Also, no serious adverse events were reported. Despite several limitations in the study design, the findings of the present study suggest that the fungus L japonica is safe to consume and it may improve cognitive function in older adults with mild cognitive decline.

    DOI: 10.37290/ctnr2641-452X.19:383-387

    Web of Science

  • Hiroko Kunikata, Naoki Yoshinaga, Kensuke Yoshimura, Daisuke Furushima .  Clinical and cost-effectiveness of nurse-led cognitive behavioral group therapy for recovery of self-esteem among individuals with mental disorders: A single-group pre-post study. .  Japan journal of nursing science : JJNS18 ( 1 ) e12371   2021.1Clinical and cost-effectiveness of nurse-led cognitive behavioral group therapy for recovery of self-esteem among individuals with mental disorders: A single-group pre-post study.Reviewed

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    AIM: To investigate whether the addition of a nurse-led cognitive behavioral group therapy for recovery of self-esteem (CBGTRS) program to usual care for individuals with mental disorders can improve clinical outcomes and reduce direct medical costs. METHODS: This study employed single-group pre-post design, and recruited 51 community-dwelling individuals with mental disorders. Participants received 12 weekly CBGTRS sessions by a nurse in addition to usual care. The primary outcome measure was the level of self-esteem, with other clinical outcomes and direct medical costs. The clinical outcomes were measured at pre-intervention (T0), intervention midpoint (T1), immediate post-intervention (T2), and 3 months post-intervention (T3). Direct medical costs were calculated for 3 months pre-intervention (A0), 3 months post-intervention (A1), between 4-6 months post-intervention (A2), and between 7-9 months post-intervention (A3). RESULTS: Self-esteem scores were significantly improved from T0 to T2 and T3 (p = .009 and .006, respectively); within-group effect sizes were .49 (small) for T0-T2, and .51 (medium) for T0-T3. Other secondary clinical outcomes for mood, cognitive bias, global functioning, and quality of life were also improved by T3 (all p < .05). The mean total direct medical costs were significantly reduced from A0 (49,569.51 JPY) to A2 and A3 (21,845.76 JPY and 25,981.69 JPY, respectively) (p = .003 and .017, respectively). CONCLUSIONS: The results suggest that nurse-led CBGTRS for mental disorders is a potentially effective approach in improving self-esteem and other clinical outcomes, and in reducing direct medical costs. Further controlled studies that address the limitations of this study are required.

    DOI: 10.1111/jjns.12371

    Scopus

    PubMed

  • 富永 健一郎, 古島 大資, 山田 浩 .  【感染症と栄養】茶ポリフェノールのインフルエンザ予防効果 .  食と医療16   014 - 020   2021.1【感染症と栄養】茶ポリフェノールのインフルエンザ予防効果

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    Language:Japanese   Publisher:(株)講談社エディトリアル  

  • Shirley T Padilla, Toshiro Niki, Daisuke Furushima, Gaowa Bai, Haorile Chagan-Yasutan, Elizabeth Freda Telan, Rosario Jessica Tactacan-Abrenica, Yosuke Maeda, Rontgene Solante, Toshio Hattori .  Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection. .  Biomolecules10 ( 11 )   2020.10Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection.Reviewed International journal

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    Acquired immunodeficiency syndrome (AIDS) complicated with tuberculosis (TB) is a global public issue. Due to the paucity of bacteria in AIDS/TB, blood-based biomarkers that reflect disease severity are desired. Plasma levels of matricellular proteins, such as osteopontin (OPN) and galectin-9 (Gal-9), are known to be elevated in AIDS and TB. Therefore, full-length (FL)-Gal9 and FL-OPN, and their truncated forms (Tr-Gal9, Ud-OPN), and 38 cytokines/chemokines were measured in the plasma of 24 AIDS (other than TB), 49 TB, and 33 AIDS/TB patients. Receiver-operating characteristic analysis was used to screen molecules that could distinguish either between disease and normal group, among each disease group, or between deceased patients and survivors. Selected molecules were further analyzed for significant differences. Tr-Gal9 had the highest ability to differentiate TB from AIDS or AIDS/TB, while Ud-OPN distinguished multidrug resistance (MDR)-TB from non-MDR TB, and extra-pulmonary TB from pulmonary TB. Molecules significantly elevated in deceased patients included; FL-Gal9, Tr-Gal9, interleukin (IL)-1 receptor antagonist, IL-17A and transforming growth factor-α in AIDS; IL-6, granulocyte colony-stimulating factor and monocyte chemotactic protein-1 in TB; and macrophage inflammatory protein-1β in AIDS/TB. From the sensitivity, specificity, and significant elevation, Tr-Gal9 is the best biomarker of inflammation and severity in AIDS and AIDS/TB.

    DOI: 10.3390/biom10111495

    PubMed

  • Keiko Unno, Daisuke Furushima, Yuzuki Nomura, Hiroshi Yamada, Kazuaki Iguchi, Kyoko Taguchi, Toshikazu Suzuki, Makoto Ozeki, Yoriyuki Nakamura .  Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffeine and Amino Acids. .  Molecules (Basel, Switzerland)25 ( 15 )   2020.8Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffeine and Amino Acids.Reviewed International journal

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    The young leaves of green tea become lighter in color than usual when protected from sunlight by a shading net for about two weeks while growing. These leaves are called "shaded white leaf tea" or SWLT. In the eluate of SWLT, the amount of amino acids (361 mg/L) was significantly higher than that in regular tea (53.5 mg/L). Since theanine and arginine, the first and second most abundant amino acids in SWLT, have significant antistress effects, we examined the antistress effect of SWLT on humans. SWLT or placebo green tea (3 g) was eluted with room-temperature water (500 mL). Participants consumed the tea for one week prior to pharmacy practice and continued for 10 days in the practice period. The state-trait anxiety inventory, an anxiety questionnaire, tended to be scored lower in the SWLT group than the placebo, but other stress markers showed no differences. The effect of the difference in SWLT components examined with mice showed that aspartic acid and asparagine, which are abundant in SWLT, counteracted the antistress effects of theanine and arginine. Large amounts of caffeine also interfered with SWLT's antistress effect. Thus, SWLT, which is high in caffeine and amino acids, suppressed depressant behavior in mice.

    DOI: 10.3390/molecules25153550

    PubMed

  • Ryo Iketani, Daisuke Furushima, Shinobu Imai, Hiroshi Yamada .  Efficacy and safety of atypical antipsychotics for psychosis in Parkinson's disease: A systematic review and Bayesian network meta-analysis. .  Parkinsonism & related disorders78   82 - 90   2020.7Efficacy and safety of atypical antipsychotics for psychosis in Parkinson's disease: A systematic review and Bayesian network meta-analysis.Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    INTRODUCTION: We performed a systematic review and Bayesian network meta-analysis to clarify the relative efficacy and safety of pimavanserin compared to atypical antipsychotics for psychosis in Parkinson's disease (PD). METHODS: PubMed, Embase, Cochrane Central Register of Controlled Trials, and Japana Centra Revuo Medicina Web were searched for relevant articles until October 31, 2019. Eligible randomized controlled trials were synthesized for efficacy (Brief Psychiatry Rating Scale [BPRS] and Clinical Global Impression Scale [CGI-S]) and safety (Unified Parkinson's Disease Rating Scale part III [UPDRS-III] and dropouts due to adverse events). The mean differences (BPRS, CGI-S, and UPDRS-III) or odds ratios (dropouts due to adverse events) between each active drug and placebo were estimated and summarized as means and 95% credible intervals, respectively. RESULTS: We identified 17 relevant trials. Clozapine showed significant efficacy (BPRS, -5.6 [-8.4 to -2.7] and CGI-S, -1.2 [-1.7 to -0.7]), with low impact on motor functions (UPDRS-III, -1.1 [-3.8 to 1.5]), but an increase in dropouts due to adverse events (2.9 [0.9 to 9.6]) as compared to placebo. Pimavanserin also showed significant efficacy (CGI-S, -0.5 [-0.9 to -0.2]) and similar impact on motor functions (UPDRS-III, 0.2 [-1.4 to 1.9]), but a tendency of increase in dropouts due to adverse events (2.2 [0.5 to 12.4]) as compared to placebo. CONCLUSIONS: Clozapine showed an efficacy with low impact on motor functions that was consistent with previous reports. Although the efficacy of pimavanserin may be inferior to that of clozapine, it had a favorable profile for the treatment of psychosis in PD.

    DOI: 10.1016/j.parkreldis.2020.07.021

    PubMed

  • Ryo Iketani, Shinobu Imai, Hiromasa Horiguchi, Daisuke Furushima, Kiyohide Fushimi, Hiroshi Yamada .  Risk stratification for physical morbidity using factors associated with atypical antipsychotic treatment in Parkinson's disease: A retrospective observational study using administrative claims data. .  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia76   189 - 194   2020.6Risk stratification for physical morbidity using factors associated with atypical antipsychotic treatment in Parkinson's disease: A retrospective observational study using administrative claims data.Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Evidence shows that atypical antipsychotics (AAPs), a treatment of psychosis in Parkinson's disease (PD), are associated with factors reflecting the severity of the disease. Therefore, we evaluated the applicability of these factors in risk stratification for physical morbidity in PD patients requiring AAPs. We implemented a nested case-control analysis using administrative claims data derived from PD inpatients in 143 National Hospitals in Japan between April 2012 and March 2017. The analysis compared PD patients exposed to AAPs with unexposed matched controls using conditional logistic regression. The cases were then stratified by the weighted score using the partial regression coefficients of extracted factors or the number of factors that they had. Physical morbidity was evaluated using length of stay (LOS) and readmission. After comparing the cases (n = 829) with the matched controls (n = 3316), 10 factors were extracted. The cases were stratified into four level groups using the weighted score, or five level groups using the number of factors. LOS was prolonged with increasing score (49.7; 58.5; 72.7; and 83.3 days) and number of factors (52.1; 52.9; 63.9; 80.7; and 79.1 days). Readmission within 30 days increased along with increasing score (5.7; 10.2; 10.2 and 12.9%) and number of factors (5.9; 9.3; 8.9; 11.3; and 14.3%). We confirmed two stratification manners for physical morbidity in PD patients requiring AAPs. These manners would be useful for considering management plan for these patients.

    DOI: 10.1016/j.jocn.2020.04.009

    PubMed

  • Obara M, Hayashi H, Namaki N, Furushima D, Matsukawa T, Kato R, Yamada H, Suzuki D, SugiyamaT .  Effects of food containing aroma compounds on oral hygiene: a preliminary pilot clinical study in elderly people requiring care .  Therapeutic Research41 ( 2 ) 125 - 131   2020.2Effects of food containing aroma compounds on oral hygiene: a preliminary pilot clinical study in elderly people requiring careReviewed

  • Daisuke Furushima, Takuma Nishimura, Norikata Takuma, Ryo Iketani, Tomohito Mizuno, Yuji Matsui, Tohru Yamaguchi, Yu Nakashima, Shinji Yamamoto, Masanobu Hibi, Hiroshi Yamada .  Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial. .  Nutrients12 ( 1 ) pii: E4   2019.12Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial.Reviewed International journal

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    Catechins, phytochemicals contained mainly in green tea, exhibit antiviral activity against various acute infectious diseases experimentally. Clinical evidence supporting these effects, however, is not conclusive. We performed a placebo-controlled, single-blind, randomized control trial to evaluate the clinical effectiveness of consumption of catechins-containing beverage for preventing acute upper respiratory tract infections (URTIs). Two hundred and seventy healthcare workers were randomly allocated to high-catechin (three daily doses of 57 mg catechins and 100 mg xanthan gum), low-catechin (one daily dose of 57 mg catechins and 100 mg xanthan gum), or placebo (0 mg catechins and 100 mg xanthan gum) group. Subjects consumed a beverage with or without catechins for 12 weeks from December 2017 through February 2018. The primary endpoint was incidence of URTIs compared among groups using a time-to-event analysis. A total of 255 subjects were analyzed (placebo group n = 86, low-catechin group n = 85, high catechin group n = 84). The URTI incidence rate was 26.7% in the placebo group, 28.2% in the low-catechin group, and 13.1% in the high-catechin group (log rank test, p= 0.042). The hazard ratio (95% confidence interval (CI)) with reference to the placebo group was 1.09 (0.61-1.92) in the low-catechin group and 0.46 (0.23-0.95) in the high-catechin group. These findings suggest that catechins combined with xanthan gum protect against URTIs.

    DOI: 10.3390/nu12010004

    PubMed

  • Ryo Iketani, Shinobu Imai, Hiromasa Horiguchi, Daisuke Furushima, Kiyohide Fushimi, Hiroshi Yamada .  Comparison of the association of risperidone and quetiapine with deteriorating performance in walking and dressing in subjects with Parkinson's disease: a retrospective cohort study using administrative claims data. .  International clinical psychopharmacology34 ( 5 ) 234 - 240   2019.9Comparison of the association of risperidone and quetiapine with deteriorating performance in walking and dressing in subjects with Parkinson's disease: a retrospective cohort study using administrative claims data.Reviewed International journal

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    This retrospective cohort study was performed to investigate the association between risperidone and deteriorating performance in walking and dressing in subjects with Parkinson's disease using the Japanese Diagnosis Procedure Combination data. These data include inpatient claims including information from the time of admission to discharge from 89 acute phase National Hospitals in Japan. The data were evaluated by implementing the inverse probability of treatment weighting, using propensity scores estimated from the clinical characteristics of subjects prescribed risperidone or quetiapine. The generalized estimation equation was used to estimate the adjusted risk ratios (aRRs) and 95% confidence intervals (CIs). In total, 304 subjects were eligible for participation, and were hospitalized between April 2012 and March 2017 (108 and 196 for risperidone and quetiapine groups, respectively). The performance of walking deteriorated at discharge, with 22.2% and 10.2% recorded at admission for the risperidone and quetiapine groups (aRR, 1.7; 95% CI, 0.9 to 3.4), respectively. The performance of dressing also deteriorated: 24.1% and 10.7% in the risperidone and quetiapine groups (aRR, 1.9; 95% CI, 1.04 to 3.7), respectively. These results suggest an association between risperidone and deteriorating performance in dressing in subjects with Parkinson's disease in comparison with quetiapine.

    DOI: 10.1097/YIC.0000000000000274

    PubMed

  • IKETANI Ryo, YAMADA Hiroshi, FURUSHIMA Daisuke, NISHIMURA Takuma, HIRAMA Yui, ONISHI Shintaro, KANBARA Hidetoshi, MORI Takuya, OTA Noriyasu, OHNO Yuko .  The effect of tea catechins on natural killer cell activity in the elderly: a pilot study .  Japanese journal of clinical pharmacology and therapeutics50 ( 4 ) 139 - 145   2019.7Reviewed

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    Language:English   Publisher:The Japanese Society of Clinical Pharmacology and Therapeutics  

    <p>The present study investigated the effect of tea catechins on the immune function in elderly subjects using a catechin-rich beverage. Twenty Japanese individuals aged over 65 years participated in the study after written informed consent was obtained. The present single-arm pilot study was conducted for an intervention period of two weeks, after one week of abstinence from consuming tea/catechin-rich products. Participants consumed one bottle of the catechin-rich beverage (total catechins, 540 mg in 350 mL) every morning. The participants' immune function including the change in natural killer (NK) cell activity (%) from before to after intervention were evaluated. Pearson's correlation coefficient (r) was calculated to investigate the correlation between NK cell activity before intervention and change in NK cell activity. The study participants appropriately consumed the catechin-rich beverage every day without any adverse event. The mean NK cell activity at baseline was 41.7 (standard deviation, 23.1). After the intervention, NK cell activity increased in 17 participants (85.0%), and the estimated mean of the differences indicated a statistically significant increase (17.1; 95% confidence interval, 9.7 to 24.5). No significant changes in C-reactive protein and interleukin-6 levels were observed. Moreover, pre-intervention NK cell activity correlated significantly with the ratio of post- to pre-intervention NK activity (r=−0.63). Although further studies using a parallel-group and comparative design are required to clarify the effect of tea catechins on the immune function, our results suggest that catechin consumption may enhance or maintain NK cell activity in the elderly.</p>

    DOI: 10.3999/jscpt.50.139

  • Keiko Unno, Daisuke Furushima, Shingo Hamamoto, Kazuaki Iguchi, Hiroshi Yamada, Akio Morita, Monira Pervin, Yoriyuki Nakamura .  Stress-reducing effect of cookies containing matcha green tea: essential ratio among theanine, arginine, caffeine and epigallocatechin gallate. .  Heliyon5 ( 5 ) e01653   2019.5Stress-reducing effect of cookies containing matcha green tea: essential ratio among theanine, arginine, caffeine and epigallocatechin gallate.Reviewed International journal

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    The stress-reducing effect of matcha, a high-quality fine-powdered green tea, has recently been clarified by animal experiments and clinical trials. However, the effect of matcha added to confectioneries is not clear. One aim of this study was to evaluate the relationship between matcha components and their stress-reducing effect in mice that were loaded with territorially-based stress. Adrenal hypertrophy, a marker of stress, was significantly suppressed in stress-loaded mice that had ingested matcha components, displaying a caffeine and epigallocatechin gallate to theanine and arginine (CE/TA) ratio of 2 or less. Another aim was to evaluate, in humans, the stress-reducing effect of matcha in cookies using test-matcha (CE/TA = 1.79) or placebo-matcha (CE/TA = 10.64). Participants, who were fifth year pharmacy college students, consumed 4.5 g of matcha in three pieces of cookie daily for 15 days. Salivary α-amylase activity, a stress marker, was significantly lower in the test-matcha group than in the placebo group. These results indicate that the CE/TA ratio of tea components is a key indicator for the suppression of stress. Moreover, matcha with a CE/TA ratio of 2 or less displays a stress-reducing effect, even if it is included in confectionery products. Such products may also benefit individuals who have no habit of drinking matcha as a beverage.

    DOI: 10.1016/j.heliyon.2019.e01653

    PubMed

  • Keiko Hosohata, Ayaka Inada, Saki Oyama, Daisuke Furushima, Hiroshi Yamada, Kazunori Iwanaga .  Surveillance of drugs that most frequently induce acute kidney injury: A pharmacovigilance approach. .  Journal of clinical pharmacy and therapeutics44 ( 1 ) 49 - 53   2019.2Surveillance of drugs that most frequently induce acute kidney injury: A pharmacovigilance approach.Reviewed International journal

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    WHAT IS KNOWN AND OBJECTIVE: Acute kidney injury (AKI) often occurs in hospitalized patients, and it is an increasing problem worldwide. Recently, clinical studies have shown that there is a strong association between drug-induced AKI and poor outcomes, including the progression of chronic kidney disease and end-stage renal disease; however, limited data are available on drug-induced AKI. The purpose of this study was to clarify the rank-order of the association of all drugs with AKI using a spontaneous reporting system database. METHODS: We performed a retrospective pharmacovigilance disproportionality analysis using the Japanese Adverse Drug Event Report (JADER) database. Adverse event reports submitted to Pharmaceuticals and Medical Devices Agency between April 2004 and January 2017 were analysed. RESULTS AND DISCUSSION: Based on 5 195 890 reports of all adverse events, we obtained 12 964 reports of AKI caused by all drugs and calculated the reporting odds ratio (ROR) and 95% confidence interval (CI) for AKI. The most frequently reported drugs were valaciclovir hydrochloride (ROR, 24.88; 95% CI: 23.1-26.8), eldecalcitol (ROR, 14.23; 95% CI, 11.68-17.33), edaravone (ROR, 14.03; 95% CI, 11.76-16.75), acyclovir (ROR, 11.17; 95% CI, 9.55-13.1), piperacillin-tazobactam (ROR, 9.23; 95% CI, 7.72-11.0), and spironolactone (ROR, 7.36; 95% CI, 6.12-8.86). WHAT IS NEW AND CONCLUSION: A comprehensive study using a pharmacovigilance database enabled us to identify the drugs that most frequently induce AKI, raising physicians' awareness of the drugs in use for patients with potentially decreased renal function.

    DOI: 10.1111/jcpt.12748

    PubMed

  • 増子沙輝, 古島大資, 池谷怜, 橋本潮里, 千葉剛, 梅垣敬三, 山田浩 .  Trends in Health Food-associated Adverse Events Analyzed Using a Long-term Database Managed by the Tokyo Metropolitan Government .  臨床薬理50 ( 5 ) 213 - 219   2019Reviewed

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Books

  • 緑茶の効能(カテキンのインフルエンザ感染に対する効果)と新型コロナウイルス感染症について

    古島大資, 大竹佑, 山田浩( Role: Joint author ,  ソフトドリンク技術資料2021年3号 pp333-341)

    一般社団法人 全国清涼飲料連合会  2022.3 

  • 食と医療:茶ポリフェノールのインフルエンザ予防効果

    富永健一郎, 古島大資, 山田 浩( Role: Joint author)

    2021.1 

  • 茶の健康機能性 ここまでわかった茶の健康機能性 20選

    大森正司 他( Role: Contributor ,  インフルエンザ予防作用)

    2020 

MISC

  • 健康食品の摂取に伴う有害事象の情報提供票及び因果関係評価アルゴリズムの実用性評価

    中村 洸友, 古島 大資, 牧之瀬 翔平, 大石 育実, 梅垣 敬三, 朝倉 敬子, 神村 裕子, 天野 進吾, 千葉 剛, 山田 浩

    日本医薬品情報学会総会・学術大会講演要旨集   23回   109 - 109   2021.6

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  • 健康食品の摂取に伴う有害事象情報の収集のための統一報告フォーマットの作成と医療従事者による実用性評価

    牧之瀬 翔平, 古島 大資, 中村 洸友, 梅垣 敬三, 朝倉 敬子, 神村 裕子, 天野 進吾, 千葉 剛, 山田 浩

    臨床薬理   52 ( 3 )   55 - 61   2021.5

  • Current status of drug therapy workshops in collaboration with University of Shizuoka, hospitals, and pharmacies.

    古島大資, 山田浩, 山田浩, 伊藤邦彦, 賀川義之, 森本達也, 黒川絢子, 並木徳之, 伊藤譲, 井上達秀, 河西きよみ, 北村修, 木村緑, 櫻井健史, 平野桂子, 松山耐至, 山田静雄, 眞鍋敬

    日本薬学会年会要旨集(Web)   141年会   28P01 - 271   2021.3

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    J-GLOBAL

  • 心理的ストレスに対するテアニン・アルギニン併用摂取作用の検討:単盲検ランダム化比較試験

    杉山 伊吹, 古島 大資, 野村 優月, 海野 けい子, 中村 順行, 山田 浩

    日本臨床薬理学会学術総会抄録集   42   3-P-U-3   2021

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    Language:Japanese   Publisher:一般社団法人 日本臨床薬理学会  

    【目的】緑茶の主要な遊離アミノ酸であるL-テアニンが、抗ストレス作用を示すことが動物実験ならびに臨床試験で報告されている。また、テアニンに次いで緑茶に多く含まれるアルギニンとの併用摂取によって、テアニンの抗ストレス作用が増強する可能性が動物実験で示されている。しかし、ヒトに対するテアニン・アルギニン併用時の影響については明らかにされていない。そこで本研究では、ヒトにおけるテアニン及びアルギニン併用摂取のストレスへの影響を、単盲検ランダム化比較試験により検討した。

    【方法】静岡県立大学の健康成人120名(平均年齢22.4歳、女性62.5%)を対象とし、十分なインフォームドコンセントによる文書同意を得た後、テアニン・アルギニン併用群(テアニン100 mg・アルギニン50 mg摂取)、テアニン単独群(テアニン100 mg摂取)、プラセボ群の3群にランダムに割り付けた。対象者へのストレス負荷として内田クレペリン精神検査法を、ストレス指標として唾液中アミラーゼ活性(salivary amylase activity: sAA)を採用した。sAAをストレス負荷前、直後、5、15、30分後に測定し、sAAの経時変化やストレス負荷前後のsAAの変化量を3群間で比較した。なお本研究は、静岡県立大学研究倫理審査委員会の承認を得て実施した。

    【結果・考察】ストレス負荷前から、負荷15分後におけるsAA変化量の平均値(標準偏差)は、テアニン・アルギニン併用群で-2.75(11.2)KIU/L、テアニン単独群で-0.40(11.5)KIU/L、プラセボ群で6.95(18.6)KIU/Lであり、テアニン・アルギニン併用群とプラセボ群間(p=0.0053)およびテアニン単独群とプラセボ群間(p=0.0413)で統計学的有意差が認められた。以上のことから、テアニンとアルギニンの併用摂取は、ヒトにおいても短時間の抗ストレス作用があることが示唆された。テアニン・アルギニン併用群とテアニン単独群間でsAA変化量の統計学的有意差は認められなかったが、テアニン・アルギニン併用摂取時にsAA減少量が大きくなる傾向がみられた。

    【結論】テアニン単独摂取時と比較して、テアニン・アルギニンの併用摂取により抗ストレス作用が増強する可能性が示唆された。しかし本研究の被検者は20代を中心としているため、結果の一般化には幅広い年齢層を対象とした大規模臨床試験によって検討する必要がある。

    DOI: 10.50993/jsptsuppl.42.0_3-p-u-3

  • ベイジアンネットワークメタアナリシスによるパーキンソン病患者に対する非定型抗精神病薬の安全性評価

    池谷 怜, 古島 大資, 今井 志乃ぶ, 山田 浩

    日本薬学会年会要旨集   140年会   28P - pm150   2020.3

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  • 創薬育薬・臨床開発を担うスタッフ養成のための大学院講座 16年目の現況

    古島 大資, 石川 智久, 賀川 義之, 尾上 誠良, 望月 亜希子, 井上 達秀, 眞鍋 敬, 山田 浩

    日本薬学会年会要旨集   140年会   26Q - pm127   2020.3

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  • 創薬育薬・臨床開発を担うスタッフ養成のための大学院講座 16年目の現況

    古島 大資, 石川 智久, 賀川 義之, 尾上 誠良, 望月 亜希子, 井上 達秀, 眞鍋 敬, 山田 浩

    日本薬学会年会要旨集   140年会   26Q - pm127   2020.3

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  • The effects of a plant worm (Isaria japonica) on cognitive function: An exploratory clinical study

    高島優莉, 古島大資, 野村優月, 宮川季士, 藤田央, 鈴木幸一, 山田浩

    日本薬学会年会要旨集(CD-ROM)   140年会   27Q - pm133   2020.3

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    J-GLOBAL

  • カイコ冬虫夏草が認知機能に及ぼす影響:探索的臨床研究

    高島優莉, 古島大資, 野村優月, 宮川季士, 藤田央, 鈴木幸一, 山田浩

    日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集   2020   2020

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  • 茶および茶カテキン類による上気道感染症予防:メタアナリシスによる検討

    富永健一郎, 梅田麻衣, 高妻和哉, 北澤秀文, 古島大資, 日比壮信, 山田浩

    日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集   2020   2020

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  • 緑茶および緑茶成分のうがいによるインフルエンザ罹患への影響:メタ解析による検討

    富永健一郎, 古島大資, 山田浩

    臨床薬理   51 ( Supplement )   S344 - S344   2020

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    J-GLOBAL

  • The effects of a plant worm (Isaria japonica) on cognitive function: An exploratory clinical study

    高島優莉, 古島大資, 野村優月, 宮川季士, 藤田央, 鈴木幸一, 山田浩

    日本薬学会年会要旨集(CD-ROM)   140th (Web)   27Q - pm133   2020

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    J-GLOBAL

  • 健康食品の摂取に伴う健康被害の情報提供票及びアルゴリズムの事業者における評価

    中村洸友, 古島大資, 牧之瀬翔平, 梅垣敬三, 朝倉敬子, 神村裕子, 佐藤陽子, 千葉剛, 山田浩

    臨床薬理   51 ( Supplement )   S299 - S299   2020

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    J-GLOBAL

  • 健康食品の安全性確保に資する情報提供,品質確保,被害情報収集体制構築に関する研究 指定成分等を含む食品を製造販売する事業者における有害事象報告フォーマットの作成

    千葉剛, 山田浩, 梅垣敬三, 朝倉敬子, 古島大資, 神村裕子, 穐山浩, 田口貴章, 佐藤陽子, 西島千陽, 小林一夫, 臼杵孝一, 陣野文彦

    健康食品の安全性確保に資する情報提供、品質確保、被害情報収集体制の構築に関する研究 令和元年度 総括・分担研究報告書(Web)   2020

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  • 健康食品の安全性確保に資する情報提供,品質確保,被害情報収集体制構築に関する研究 健康被害情報の迅速・簡便な収集を目指した報告フォーマットならびにアルゴリズムの検討

    山田浩, 朝倉敬子, 梅垣敬三, 神村裕子, 古島大資

    健康食品の安全性確保に資する情報提供、品質確保、被害情報収集体制の構築に関する研究 令和元年度 総括・分担研究報告書(Web)   2020

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  • A Bayesian network meta-analysis to evaluate the safety of atypical antipsychotics for patients with Parkinson’s disease.

    池谷怜, 池谷怜, 古島大資, 今井志乃ぶ, 山田浩

    日本薬学会年会要旨集(CD-ROM)   140th (Web)   28P - pm150   2020

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    J-GLOBAL

  • 健康食品の安全性確保に資する情報提供,品質確保,被害情報収集体制構築に関する研究 健康被害情報の迅速・簡便な収集を目指した報告フォーマットならびにアルゴリズムの検討

    山田浩, 朝倉敬子, 梅垣敬三, 神村裕子, 古島大資, 牧之瀬翔平

    健康食品の安全性確保に資する情報提供、品質確保、被害情報収集体制構築に関する研究 平成30年度 総括・分担研究報告書(Web)   2019

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  • 茶カテキンのインフルエンザ感染抑制作用に関する検討

    大西慎太郎, 大西慎太郎, 古島大資, 西村拓馬, 中島雄, 三澤幸一, 山本真士, 森卓也, 森卓也, 太田宣康, 紅林佑希, 田熊規方, 山田浩, 鈴木隆

    日本小児呼吸器学会雑誌   30 ( Supplement )   128 - 128   2019

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  • Report of the 4th Annual Meeting of the Tokai & Hokuriku Regions of the JSCPT

    FURUSHIMA Daisuke, UCHIDA Shinya, YAMADA Hiroshi

    Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics   50 ( 6 )   275 - 278   2019

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    DOI: 10.3999/jscpt.50.275

  • 特別養護老人ホーム入所者におけるアロマ成分含有食品摂取時の口腔内衛生環境の変化

    小原道子, 小原道子, 林秀樹, 生木庸寛, 生木庸寛, 松川泰治, 加藤梨那, 古島大資, 山田浩, 杉山正

    臨床薬理   50 ( Supplement )   S357 - S357   2019

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  • 模擬被験者を用いた臨床試験のインフォームドコンセント演習の実践

    春田愛, 古島大資, 森田みつ子, 鈴木崇代, 杉山慎一, 望月亜希子, 石井康子, 山田浩

    CRCと臨床試験のあり方を考える会議プログラム・抄録集   19th   2019

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  • 抹茶を含むクッキーの抗ストレス作用

    海野けい子, 古島大資, 浜本伸吾, 井口和明, 山田浩, パービン モニラ, 中村順行

    日本抗加齢医学会総会プログラム・抄録集   19th   233 - 233   2019

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  • 成人医療福祉施設従事者を対象とした茶由来成分含有飲料の摂取による急性上気道炎の発症抑制効果の検討

    西村拓馬, 古島大資, 田熊規方, 池谷怜, 日比壮信, 松井祐司, 三澤幸一, 中島雄, 山本真士, 山田浩

    食品薬学シンポジウム講演要旨集   8th (Web)   2019

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  • 急性上気道炎発症に対する茶由来成分含有飲料の有効性の検証;ランダム化単盲検並行群間比較試験

    古島大資, 池谷怜, 西村拓馬, 水野智仁, 中島雄, 松井祐司, 山本真士, 日比壮信, 大崎紀子, 山田浩

    日本栄養・食糧学会大会講演要旨集   73rd   287 - 287   2019

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    J-GLOBAL

  • 健康食品の摂取に伴う健康被害の因果関係評価アルゴリズムの架空事例試用による妥当性の検討

    中村洸友, 古島大資, 牧之瀬翔平, 梅垣敬三, 朝倉敬子, 神村裕子, 石川達郎, 佐藤陽子, 千葉剛, 山田浩

    臨床薬理   50 ( Supplement )   S254 - S254   2019

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    J-GLOBAL

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Presentations

  • Hiroshi Yamada, Daisuke Fuushima   Clinical Effects of Green Tea Components on Prevention of Influenza Infection   International conference

    14th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT)  2019.6 

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Research Projects

  • 緑茶うがいによるインフルエンザ予防:ランダム化比較試験による濃度依存性の検討

    Grant number:20K10382  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    山田 浩, 古島 大資

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  • 健康サポート薬局普及推進に向けた業務最適化支援モデルの構築と有用性評価

    Grant number:19K19391  2019.4 - 2022.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    古島 大資

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  • 健康サポート薬局普及推進に向けた業務最適化支援モデルの構築と有用性評価

    2019.4 - 2021.3

    文部科学省  科学研究助成金 若手研究 

    古島 大資

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    Authorship:Principal investigator  Grant type:Competitive