Updated on 2025/03/24

写真a

 
YAMASAKI Masatoshi
 
Organization
Research Field in Fisheries, Agriculture, Fisheries and Veterinary Medicine Area Faculty of Fisheries Department of Fisheries Science and Technology Assistant Professor
Title
Assistant Professor

Degree

  • 博士（水産学） ( 2014.3   鹿児島大学 )

Research Interests

  • 魚病学

  • 生体防御学

  • 生体応答学

  • 免疫毒性学

Education

  • Kagoshima University

    - 2014.3

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    Country： Japan

  • Kagoshima University

    - 2011.3

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    Country： Japan

  • Kagoshima University

    - 2009.3

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    Country： Japan

Research History

  • Kagoshima University   Research Field in Fisheries, Agriculture, Fisheries and Veterinary Medicine Area Faculty of Fisheries Department of Fisheries Science and Technology   Assistant Professor

    2020.11

  • Kagoshima University   Faculty of Fisheries   Assistant Professor

    2020.11

  • Fisheries Research Agency   National Institute Research Agency   Researcher

    2015.5 - 2020.10

  • University of the Ryukyus   Researcher

    2014.5 - 2015.5

Professional Memberships

  • 日本環境毒性学会

    2021.8

  • 日本生体防御学会

    2014.6

  • 日本生体防御学会

    2014

  • 日本魚病学会

    2010.9

  • The Japanese Society of Fish Pathology

    2010

 

Papers

  • Shusaku Fukugami, Masatoshi Yamasaki, Emiko Kokushi, Seiichi Uno .  Influence of CYP1A and AhR modulation on polycyclic aromatic hydrocarbon-induced developmental defects in Japanese medaka. .  Aquatic toxicology (Amsterdam, Netherlands)280   107267 - 107267   2025.2International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    Polycyclic aromatic hydrocarbons (PAHs) are known to induce developmental malformations in fish embryos. However, the interaction between aryl hydrocarbon receptor (AhR) and cytochrome P450 (CYP) in PAH-induced development defects remains unclear. Therefore, we investigated the effects of the CYP1A inhibitor piperonylbutoxide (PBO) and the AhR antagonist CH223191 (CH) on the development of Japanese medaka (Oryzias Latipes) embryos exposed to different PAHs. Japanese medaka embryos were exposed to three conditions: PAH alone, PAH and PBO, and PAH and CH. Microscopic observations were performed to examine the presence of developmental defects. Although neither phenanthrene (Phe) nor fluoranthene (Flu) induced morphological malformations in larvae, benzo(a)anthracene (BaA) exposure induced craniofacial deformities in the larvae. Additionally, BaA and PBO co-exposure significantly increased the rate and severity of malformations. Pyrene (Pyr) exposure induced craniofacial defects, cardiac hypertrophy, pericardial edema, and spinal curvature, which were attenuated by exposure to either CH or PBO. Collectively, these findings suggest that structurally different PAHs exert their toxic effects via distinct mechanisms during fish development.

    DOI： 10.1016/j.aquatox.2025.107267

    Scopus

    PubMed

  • Tamaki Seki, Motoaki Katsura, Masatoshi Yamasaki, Kazuki Yamashita, Emiko Kokushi, Seiichi Uno .  Effects of diphenhydramine exposure on reproduction of mature Japanese medaka (Oryzias latipes). .  Chemosphere358   142163 - 142163   2024.4International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    Diphenhydramine (DPH) is an antihistamine drug. It has been frequently detected in the environment, because it is not completely degraded in wastewater treatment plants. Recent studies have shown the adverse effects of DPH exposure to various aquatic organisms; however, its chronic effects on fish have been poorly elucidated. In this study, several pairs of mature Japanese medaka (Oryzias latipes) were exposed to DPH for a long period to determine the effects of DPH exposure on the subsequent generations, number of spawned and fertilized eggs, expression of sex-related genes, feeding behavior, embryo development, hatching rate, malformations among the hatched larvae, and mortality rate. The number of spawned eggs significantly decreased, when the parent fish were continuously exposed to 31.6 μg/L DPH for over 46 days. DPH exposure also altered the feeding behavior of medaka individuals, and increased the larval mortality rate. The effects of DPH exposure to fish may occur to some extent in the actual aquatic environment, although the risk evaluations in the field are limited.

    DOI： 10.1016/j.chemosphere.2024.142163

    Scopus

    PubMed

  • Tomokazu Takano, Satoshi Miwa, Tomomasa Matsuyama, Ikunari Kiryu, Miho Honjo, Takamitsu Sakai, Yuta Matsuura, Masatoshi Yamasaki, Akira Kumagai, Chihaya Nakayasu .  Clinical symptoms and histopathological changes in coho salmon affected by the erythrocytic inclusion body syndrome (EIBS) are caused by the infection of piscine orthoreovirus 2 (PRV-2). .  Journal of fish diseases   e13939   2024.3International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    The relationship of histopathological changes and the infection of Piscine orthoreovirus 2 (PRV-2) was investigated in coho salmon that were suffering from the erythrocytic inclusion body syndrome (EIBS). Immunohistochemical observations revealed abundant σ1 protein of PRV-2 in the spongy layer of the ventricle of the heart, where severe myocarditis was observed. In the spleen, the virus protein was detected in many erythrocytes, some of which were spherical-shaped and apparently dead. The number of erythrocytes was decreased in the spleen compared to the apparently healthy fish. The virus protein was also detected in some erythrocytes in blood vessels. The viral protein was often detected in many macrophages ingesting erythrocytes or dead cell debris in the spleen or in the kidney sinusoids. Large amounts of the viral genomic segment L2 were also detected in these organs by RT-qPCR. Many necrotic foci were found in the liver, although the virus protein was not detected in the hepatocytes. These results suggest that the primary targets of PRV-2 are myocardial cells and erythrocytes and that clinical symptoms such as anaemia or jaundice and histopathological changes such as myocarditis in EIBS-affected coho salmon are caused by PRV-2 infection.

    DOI： 10.1111/jfd.13939

    PubMed

  • Kumagai Akira, Takano Tomokazu, Yamasaki Masatoshi, Matsuyama Tomomasa, Sakai Takamitsu, Honjo Miho, Tomikawa Nasumi .  Virucidal Effect of Disinfectants against Erythrocytic Inclusion Body Syndrome (EIBS) Virus Piscine orthoreovirus 2 .  魚病研究57 ( 2 )   2022

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  • Tomomasa Matsuyama, Tomokazu Takanoa, Miho Honjo, Takumi Kikuta, Akatsuki Nawata, Akira Kumagai, Ryo Honda, Takamitsu Sakai, Jun Kurita, Sachiko Terashima, Masatoshi Yamasaki, Yuta Matsuura, Yuko Nishizawa, Chihaya Nakayasu .  Enhancement of piscine orthoreovirus-2 DNA vaccine potency by linkage of antigen gene to a trigger factor gene or signal peptide genes .  Aquaculture533   2021.2Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Tomomasa Matsuyama, Tomokazu Takano, Miho Honjo, Takumi Kikuta, Akatsuki Nawata, Akira Kumagai, Ryo Honda, Takamitsu Sakai, Jun Kurita, Sachiko Terashima, Masatoshi Yamasaki, Yuta Matsuura, Yuko Nishizawa, Chihaya Nakayasu .  Enhancement of piscine orthoreovirus-2 DNA vaccine potency by linkage of antigen gene to a trigger factor gene or signal peptide genes .  Aquaculture533   736163 - 736163   2021.2

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.aquaculture.2020.736163

  • Soetsu Yanagi, Jun Satoh, Tohru Mekata, Takamitsu Sakai, Hidemasa Kawakami, Shogo Harakawa, Sho Shirakashi, Shogo Hamano, Kei Fukudome, Kazuhiko Wada, Masatoshi Yamasaki, Toyohiro Nishioka, Chihaya Nakayasu, Koh-ichiro Mori .  Chemical Treatment of Beko Disease in <i>Seriola</i> Fishes: Laboratory Trials of Commercially Available Fishery and Veterinary Medicines .  Fish Pathology56 ( 2 ) 62 - 70   2021

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Fish Pathology  

    <p>Beko disease, caused by infection of the microsporidian <i>Microsporidium seriolae</i>, results in significant damage to farmed amberjack, <i>Seriola</i> spp., in Japan. ​Little is known about the disease, including the general biology of the causative agent, and no therapeutic method has been established to treat it. ​We determine the therapeutic efficacies of various drugs by administering them in-feed to juvenile <i>Seriola</i> spp. naturally infected with <i>M. seriolae</i>. ​Candidate drugs include commercially available fishery anthelminthic, febantel, and eight other compounds. ​Fish were given various doses of drugs, and <i>M. seriolae</i> infection in their trunk muscle was then checked by quantitative PCR (qPCR) and macroscopic cyst detection. ​Fish treated with febantel at an early stage of infection had significantly lower rates of cyst formation and qPCR-positive. ​However, febantel administered to fish after cyst formation did not reduce cyst numbers. ​Other drugs showed no apparent efficacy to prevent cyst formation or to promote cyst reduction. ​Results indicate febantel is a promising therapeutic agent for beko disease when applied at an early stage of infection.</p>

    DOI： 10.3147/jsfp.56.62

    Scopus

    CiNii Research

  • Goro Matsuzaki, Masatoshi Yamasakia, Toshiki Tamura, Masayuki Umemura .  Dispensable role of chemokine receptors in migration of mycobacterial antigen-specific CD4+ T cells into Mycobacterium-infected lung .  Immunobiology224 ( 3 ) 440 - 448   2019.5Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1016/j.imbio.2019.01.006

  • Goro Matsuzaki, Masatoshi Yamasaki, Toshiki Tamura, Masayuki Umemura .  Dispensable role of chemokine receptors in migration of mycobacterial antigen-specific CD4+ T cells into Mycobacterium-infected lung. .  Immunobiology224 ( 3 ) 440 - 448   2019.5International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    Mycobacterial antigen-specific CD4+ Th1 cells have pivotal role in protective immunity against mycobacterial infections including pulmonary tuberculosis. In the course of the infection, Th1 cells differentiate in the lung-draining lymph nodes and migrate into the infected lung. Chemokine receptors on T cells are involved in T cell migration into the intestine and skin. However, role of chemokine receptors in the migration of CD4+ T cells into the lung is not yet established. To address the issue, the role of chemokine receptors in T cell migration into the mycobacteria-infected lung was analyzed using mycobacterial Ag85B peptide 25-specific T cell receptor-transgenic (P25) CD4+ T cells. The P25 T cells in the Mycobacterium bovis BCG-infected lung and lung-draining mediastinal lymph node expressed chemokine receptors CCR5, CCR6, CXCR3 and CXCR5 which bind chemokines expressed by the BCG-infected lung. To further analyze the role of the chemokine receptors in the migration of the BCG-primed P25 T cells into the lung or mediastinal lymph node, the P25 T cells were adoptively transferred into the BCG-infected wild type mice, and their migration into the lung was monitored. Unexpectedly, blocking of chemokine receptor function with pertussis toxin, a G-protein inhibitor, failed to suppress migration of the T cells into the infected lung although the treatment completely blocked migration of the mediastinal lymph node P25 T cells into the recipient lymph node. The results suggest that interaction of chemokine receptors on mycobacterial antigen-specific Th1 cells with chemokines is dispensable in their migration into the mycobacteria-infected lung.

    DOI： 10.1016/j.imbio.2019.01.006

    PubMed

  • Masatoshi Yamasaki, Takamitsu Sakai, Takafumi Ito, Koh-ichiro Mori .  Bactericidal Effects of Disinfectants on Yersinia ruckeri .  Fish Pathology54 ( 4 ) 198 - 201   2017.12Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Masatoshi Yamasaki, Takamitsu Sakai, Takafumi Ito, Koh-ichiro Mori .  Bactericidal Effects of Disinfectants on <i>Yersinia ruckeri</i> .  Fish Pathology52 ( 4 ) 198 - 201   2017

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    Publishing type：Research paper (scientific journal)   Publisher：The Japanese Society of Fish Pathology  

    DOI： 10.3147/jsfp.52.198

  • Masatoshi Yamasaki, Kyosuke Araki, Kota Maruyoshi, Megumi Matsumoto, Chihaya Nakayasu, Tadaaki Morimoto, Teruyuki Nakanishi, Atsushi Yamamoto .  Comparative analysis of adaptive immune response after vaccine trials using live attenuated and formalin-killed cells of Edwardsiella tarda in ginbuna crucian carp (Carassius auratus langsdorfii) .  Fish & Shellfish Immunology45   437 - 442   2015.5Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Masatoshi Yamasaki, Kyosuke Araki, Teruyuki Nakanishi, Chihaya Nakayasu, Atsushi Yamamoto .  Role of CD4+ and CD8a+ T cells in protective immunity against Edwardsiella tarda infection of ginbuna crucian carp, Carassius auratus langsdorfii .  Fish & Shellfish Immunology36   299 - 304   2014.12Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER  

    DOI： http://dx.doi.org/10.1016/j.fsi.2013.11.016

  • Masatoshi Yamasaki, Kyosuke Araki, Teruyuki Nakanishi, Chihaya Nakayasu, Yasutoshi Yoshiura, Takaji Iida, Atsushi Yamamoto .  Adaptive immune response to Edwardsiella tarda infection in ginbuna crucian carp, Carassius auratus langsdorfii .  Veterinary Immunology and Immunopathology153   83 - 90   2013.5Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： http://dx.doi.org/10.1016/j.vetimm.2013.02.004

    Institutional Repository URL

  • Kyosuke Araki, Fumio Takizawa, Masatoshi Yamasaki, Mariko Esumi, Tadaaki Moritomo, Mitsuru Ototake, Atsushi Yamamoto, Teruyuki Nakanishi .  Expression profiles of interferon gamma genes in response to immunostimulants and alloantigen in ginbuna crucian carp Carassius auratus langsdorfii .  FISHERIES SCIENCE   2013.3Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

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Research Projects

  • 魚類のAhRを介したヘルパーT細胞の分化機構の解明と感染症に対する感受性に関する研究

    Grant number：24K15318  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    山崎 雅俊

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

  • レッドマウス病の感染モデルを利用した細菌感染症の感染感受性に関わる宿主因子の解明

    Grant number：20K06245  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    坂井 貴光, 山崎 雅俊

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    Grant amount：\3380000 （ Direct Cost: \2600000 、 Indirect Cost：\780000 ）