Updated on 2026/03/21

写真a

 
TAGAWA Yoshiaki
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Neurology Professor
Title
Professor
Degree
(1999.7 Kyoto University)
External link

Research Interests

  • Neuroscience

Research Areas

Neuroscience-general

Education

  • 1994.4 - 1997.11    Kyoto University

  • 1988.4 - 1994.3    Kyoto University

Professional Memberships

  • 2017.7    日本生理学会

  • 2004.4    日本神経科学会

  • 1999.4    北米神経科学会(Society for Neuroscience)

Studying abroad experiences

  • 2000.10 - 2004.2   アメリカハーバード大学(Harvard Medical School)   研究員

Qualification acquired

  • Doctor

 

Papers

  • Inagaki S, Nakagawa-Tamagawa N, Huynh NZ, Kambe Y, Yagasaki R, Manita S, Fujimoto S, Noda T, Mori M, Teranishi A, Takeshima H, Ishikawa K, Naitou Y, Yokoyama T, Sakamoto M, Hayashi K, Kitamura K, Tagawa Y, Okuda S, Sato TK, Imai T .  Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo. .  Nature methods   2026.3

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    Language:English  

    DOI: 10.1038/s41592-026-03023-y

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  • Egashira R., Meng-Tsen K., Nakagawa-Tamagawa N., Fujimoto S., Inagaki S., Takagi T., Miyakawa T., Tagawa Y., Imai T. .  Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence .  Science Advances12 ( 3 ) 1 - 18   2026.1

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    Language:Japanese   Publisher:Science Advances  

    The development of cognitive functions continues into adolescence. However, it is not fully understood how cortical circuitry changes during adolescence. Here, we performed a comprehensive super-resolution mapping of dendritic spines in layer 5 extratelencepharic-projecting (L5 ET) neurons in the primary somatosensory cortex in mice. In adults, the dendritic spines are highly enriched in the middle compartment of the apical dendrites (spine density “hotspot”), where dendritic calcium spikes are generated. In early development, dendritic spines are evenly distributed. During adolescence, however, the spine density increases specifically in the middle compartment of the apical dendrites in an experience-dependent manner, while other dendritic compartments show a slight reduction. Furthermore, spine accumulation at the hotspot was specifically impaired in mouse models of schizophrenia, demonstrating a link between adolescent spine formation and neuropsychiatric disorders. Our finding suggests that the dendritic compartment-specific spine formation during adolescence shapes nonlinear dendritic integration in L5 ET neurons and supports the maturation of cognitive functions.

    DOI: 10.1126/sciadv.adw8458

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  • 田川 義晃 .  【「新しい分子生物学技術を用いた生体機能解析」】In utero遺伝子導入法について .  LABIO 21 ( 89 ) 8 - 10   2023.5

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    Language:Japanese   Publisher:(公社)日本実験動物協会  

  • Yuta Tezuka†, Kenta M Hagihara†, Kenichi Ohki, Tomoo Hirano, Yoshiaki Tagawa .  Developmental stage-specific spontaneous activity contributes to callosal axon projections .  eLife11 ( e72435 ) 1 - 15   2022.8Reviewed

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.7554/eLife.72435

  • Yuta Tezuka, Kenta M, Hagihara, Kenichi Ohki, Tomoo Hirano, Yoshiaki Tagawa .  Developmental stage-specific spontaneous activity contributes to callosal axon projections .  eLife11 ( e72435 ) 1 - 15   2022.8Reviewed

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.72435

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  • Nao Nakagawa-Tamagawa, Emi Kirino, Kohtaroh Sugao, Hidetaka Nagata, Yoshiaki Tagawa .  Involvement of Calcium-Dependent Pathway and β Subunit-Interaction in Neuronal Migration and Callosal Projection Deficits Caused by the Cav1.2 I1166T Mutation in Developing Mouse Neocortex .  Frontiers in Neuroscience15 ( 747951 ) 1 - 13   2021.12Reviewed

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.3389/fnins.2021.747951

  • Nao Nakagawa-Tamagawa, Emi Kirino, Kohtaroh Sugao, Hidetaka Nagata, Yoshiaki Tagawa .  Involvement of Calcium-Dependent Pathway and β Subunit-Interaction in Neuronal Migration and Callosal Projection Deficits Caused by the Cav1.2 I1166T Mutation in Developing Mouse Neocortex .  Frontiers in Neuroscience15   747951   2021.12Reviewed

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    <bold>Introduction:</bold> Gain-of-function mutations in the L-type Ca<sup>2+</sup> channel Cav1.2 cause Timothy syndrome (TS), a multisystem disorder associated with neurologic symptoms, including autism spectrum disorder (ASD), seizures, and intellectual disability. Cav1.2 plays key roles in neural development, and its mutation can affect brain development and connectivity through Ca<sup>2+</sup>-dependent and -independent mechanisms. Recently, a gain-of-function mutation, I1166T, in Cav1.2 was identified in patients with TS-like disorder. Its channel properties have been analyzed <italic>in vitro</italic> but <italic>in vivo</italic> effects of this mutation on brain development remain unexplored.

    <bold>Methods:</bold><italic>In utero</italic> electroporation was performed on ICR mice at embryonic day 15 to express GFP, wild-type, and mutant Cav1.2 channels into cortical layer 2/3 excitatory neurons in the primary somatosensory area. The brain was fixed at postnatal days 14–16, sliced, and scanned using confocal microscopy. Neuronal migration of electroporated neurons was examined in the cortex of the electroporated hemisphere, and callosal projection was examined in the white matter and contralateral hemisphere.

    <bold>Results:</bold> Expression of the I1166T mutant in layer 2/3 neurons caused migration deficits in approximately 20% of electroporated neurons and almost completely diminished axonal arborization in the contralateral hemisphere. Axonal projection in the white matter was not affected. We introduced second mutations onto Cav1.2 I1166T; L745P mutation blocks Ca<sup>2+</sup> influx through Cav1.2 channels and inhibits the Ca<sup>2+</sup>-dependent pathway, and the W440A mutation blocks the interaction of the Cav1.2 α1 subunit to the β subunit. Both second mutations recovered migration and projection.

    <bold>Conclusion:</bold> This study demonstrated that the Cav1.2 I1166T mutation could affect two critical steps during cerebrocortical development, migration and axonal projection, in the mouse brain. This is mediated through Ca<sup>2+</sup>-dependent pathway downstream of Cav1.2 and β subunit-interaction.

    DOI: 10.3389/fnins.2021.747951

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  • 田川 義晃 .  哺乳類大脳の広域・局所神経回路構築ロジックの解明 .  上原記念生命科学財団研究報告集35   1 - 5   2021.12

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    Language:Japanese   Publisher:(公財)上原記念生命科学財団  

  • Kenta M Hagihara, Ayako Wendy Ishikawa, Yumiko Yoshimura, Yoshiaki Tagawa, Kenichi Ohki .  Long-Range Interhemispheric Projection Neurons Show Biased Response Properties and Fine-Scale Local Subnetworks in Mouse Visual Cortex .  Cerebral Cortex31 ( 2 ) 1307 - 1315   2021.1Invited Reviewed International journal

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    Integration of information processed separately in distributed brain regions is essential for brain functions. This integration is enabled by long-range projection neurons, and further, concerted interactions between long-range projections and local microcircuits are crucial. It is not well known, however, how this interaction is implemented in cortical circuits. Here, to decipher this logic, using callosal projection neurons (CPNs) in layer 2/3 of the mouse visual cortex as a model of long-range projections, we found that CPNs exhibited distinct response properties and fine-scale local connectivity patterns. In vivo 2-photon calcium imaging revealed that CPNs showed a higher ipsilateral (to their somata) eye preference, and that CPN pairs showed stronger signal/noise correlation than random pairs. Slice recordings showed CPNs were preferentially connected to CPNs, demonstrating the existence of projection target-dependent fine-scale subnetworks. Collectively, our results suggest that long-range projection target predicts response properties and local connectivity of cortical projection neurons.

    DOI: 10.1093/cercor/bhaa297

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    Other Link: https://pubmed.ncbi.nlm.nih.gov/33063102/

  • Bando Y, Irie K, Shimomura T, Umeshima H, Kushida Y, Kengaku M, Fujiyoshi Y, Hirano T, & Tagawa Y. .  Control of spontaneous Ca2+ transients is critical for neuronal maturation in the developing neocortex. .  Cerebral Cortex26 ( 1 ) 106 - 117   2016.1Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/cercor/bhu180

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  • Hagihara KM, Murakami T, Yoshida T, Tagawa Y, Ohki K. .  Neuronal activity is not required for the initial formation and maturation of visual selectivity. .  Nature Neuroscience18 ( 12 ) 1780 - 1788   2015.12Reviewed

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    DOI: 10.1038/nn.4155

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  • Bando Y, Hirano T, Tagawa Y. .  Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex. .  Cerebral Cortex24 ( 4 ) 1017 - 1029   2014.4Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/cercor/bhs387

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  • Hayashi Y, Tagawa Y, Yawata S, Nakanishi S, Funabiki K. .  Spatio-temporal control of neural activity in vivo using fluorescence microendoscopy. .  European Journal of Neuroscience36 ( 6 ) 2722 - 2732   2012.9Reviewed

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    DOI: 10.1111/j.1460-9568.2012.08191.x

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  • Mizuno H, Hirano T, Tagawa Y. .  Pre-synaptic and post-synaptic neuronal activity supports the axon development of callosal projection neurons during different post-natal periods in the cerebral cortex. .  European Journal of Neuroscience31 ( 3 ) 410 - 424   2010.2Reviewed

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    DOI: 10.1111/j.1460-9568.2009.07070.x

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  • Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H. .  Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. .  The Journal of Neuroscience29 ( 43 ) 13720 - 13729   2009.10Reviewed

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    DOI: 10.1523/JNEUROSCI.3018-09.2009

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  • Mizuno H, Hirano T, Tagawa Y. .  Evidence for activity-dependent cortical wiring: Formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity. .  The Journal of Neuroscience27 ( 25 ) 6760 - 6770   2007.6Reviewed

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    DOI: 10.1523/JNEUROSCI.1215-07.2007

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  • Tagawa Y, Kanold PO, Majdan M, & Shatz CJ. .  Multiple periods of functional ocular dominance plasticity in mouse visual cortex. .  Nature Neuroscience8 ( 3 ) 380 - 388   2005.3Reviewed

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    DOI: 10.1038/nn1410

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  • Tagawa Y, Sawai H, Ueda Y, Tauchi M, Nakanishi S. .  Immunohistological studies of metabotropic glutamate receptor-subtype 6-deficient mice show no abnormality of retinal cell organization and ganglion cell maturation. .  The Journal of Neuroscience19 ( 7 ) 2568 - 2579   1999.7Reviewed

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    Language:English   Publishing type:Doctoral thesis  

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  • Tagawa Y, Sawai H, Ueda Y, Tauchi M, & Nakanishi S. .  Immunohistological studies of metabotropic glutamate receptor-subtype 6-deficient mice show no abnormality of retinal cell organization and ganglion cell maturation. .  The Journal of Neuroscience19 ( 7 ) 2568 - 2579   1999.4Reviewed

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  • Hashimoto T, Inazawa J, Okamoto N, Tagawa Y, Bessho Y, Honda Y, & Nakanishi S. .  The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6. .  European Journal of Neuroscience9   1226 - 1235   1997.6Reviewed

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  • Masu M, Iwakabe H, Tagawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi K, Nakamura Y, Shigemoto R, Takada M, Nakamura K, Nakao K, Katsuki M, & Nakanishi S. .  Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. .  Cell80 ( 5 ) 757 - 765   1995.3Reviewed

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  • Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, & Nakanishi S. .  Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. .  Genes & Development 6   2620 - 2634   1992.12Reviewed

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Books

  • Principles of Neurobiology

    Li Qun Luo( Role: Joint translator ,  Wiring of the visual system)

    Garland Science  2017.8 

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    Total pages:736   Responsible for pages:p169-210   Language:Japanese Book type:Textbook, survey, introduction

MISC

  • In utero 遺伝子導入法について Invited

    田川 義晃

    LABIO21   89   8 - 10   2023.5

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:日本実験動物協会  

  • Construction of visual circuits by spontaneous neuronal activity

    Yoshiaki Tagawa

    70 ( 1 )   23 - 27   2019.2

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • 【脳神経回路のダイナミクスから探る脳の発達・疾患・老化】自発神経活動と視覚系神経回路のスクラップ&ビルド

    田川 義晃

    生体の科学   70 ( 1 )   23 - 27   2019.2

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    Publisher:(公財)金原一郎記念医学医療振興財団  

  • Activity-dependent callosal axon projections in neonatal mouse cerebral cortex. Reviewed

    Tagawa Y & Hirano T.

    Neural Plasticity   2012 ( 797295 )   1 - 10   2012.10

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)  

    DOI: 10.1155/2012/797295

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  • Activity-dependent development of interhemispheric connections in the visual cortex. Reviewed

    Tagawa Y, Mizuno H, Hirano T.

    Reviews in the Neurosciences   19 ( 1 )   19 - 28   2008.2

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Presentations

  • Yoshiaki Tagawa   Activity-dependent callosal axon projections in the developing neocortex  

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Yoshiaki Tagawa et al.,   Activity-dependent formation and restoration of callosal axon projections in developing neocortex   Invited International conference

    Principles of Neocortical Development and Evolution  東京都医学総合研究所

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    Event date: 2019.7

    Language:English   Presentation type:Poster presentation  

    Venue:東京都医学総合研究所  

  • Yoshiaki Tagawa, Yuta Tezuka, Kenta Hagihara, Kenichi Ohki, Tomoo Hirano   Activity-dependent formation and restoration of callosal axon projections in developing neocortex.   International conference

    FAOPS Congress in conjunction with the 96th Annual meeting of the Physiological Society of Japan. 

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    Event date: 2019.3

    Language:English   Presentation type:Poster presentation  

  • Yoshiaki Tagawa   Activity-dependent callosal axon projections in the developing neocortex.   Invited International conference

    National Institute of Genetics

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    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:National Institute of Genetics  

  • Activity-dependent callosal axon projections in developing neocortex  

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Yoshiaki Tagawa   Activity-dependent formation and restoration of callosal axon projections in developing neocortex   International conference

    Cold Spring Harbor Asia meeting  Cold Spring Harbor Asia

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    Event date: 2018.9

    Language:English   Presentation type:Poster presentation  

  • 田川義晃   自発神経活動による大脳神経回路の形成機構   Invited

    生理学研究所「情動研究会」  生理学研究所

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:愛知県岡崎市  

  • 田川義晃   マウス大脳の マクロな領域間投射と局所回路をつなぐ構築ロジック  

    鹿児島神経科学研究会 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島県指宿市  

  • 田川義晃   神経活動による大脳神経回路の形成   Invited

    鹿児島神経科学研究会  鹿児島神経科学研究会

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    Event date: 2017.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:鹿児島大学  

  • Activity-dependent formation and restoration of callosal axon projections in the developing mouse neocortex.   Invited

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    Event date: 2017.8

    Language:English   Presentation type:Oral presentation (general)  

  • Tagawa Y   New approaches to research and development for generation and regeneration of neural circuits   Invited International conference

    Neuroscience2017 

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    Event date: 2017.7

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Makuhari Messe  

  • Tagawa Yoshiaki, Tezuka Yuta, Hagihara Kenta, Ohki Kenichi, Hirano Tomoo   発達期の新皮質における脳梁軸索投射の活動依存的形成と回復(Activity-dependent formation and restoration of callosal axon projections in developing neocortex)  

    The Journal of Physiological Sciences  2019.6  (一社)日本生理学会

  • 中川 直, 水野 秀信, 田川 義晃   脳梁投射軸索のダイナミクスに関するtime-lapseイメージング(Time-lapse imaging of callosal axon projection dynamics in vivo)  

    日本生理学雑誌  2021.2  (一社)日本生理学会

  • 玉川 直[中川], 桐野 恵美, 菅生 厚太郎, 永田 英孝, 田川 義晃   ティモシー症候群に関連するCav1.2のI1166T変異は発達期のマウス大脳皮質において神経細胞の移動と脳梁投射を障害する  

    日本生理学雑誌  2022.2  (一社)日本生理学会

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  • Nakagawa Tamagawa Nao, Kirino Emi, Sugao Kohtaroh, Nagata Hidetaka, Tagawa Yoshiaki   ティモシー症候群に関連するCav1.2のI1166T変異は発達中のマウス大脳新皮質における神経細胞の遊走と脳梁投射を障害する(The I1166T mutation in Cav1.2 associated with Timothy Syndrome impairs neuronal migration and callosal projections in developing mouse neocortex)  

    The Journal of Physiological Sciences  2022.12  (一社)日本生理学会

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  • Inagaki Shigenori, Tamagawa Nao, Huynh Nathan, Kambe Yuki, Yagasaki Rei, Manita Satoshi, Fujimoto Satoshi, Noda Takahiro, Naito Yuki, Hayashi Katsuhiko, Kitamura Kazuo, Tagawa Yoshiaki, Okuda Satoru, Sato Tatsuo, Imai Takeshi   Spatial-temporal understanding of multicellular interactions based on quantification of biological signal information Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo(タイトル和訳中)  

    The Journal of Physiological Sciences  2025.3  (一社)日本生理学会

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  • 玉川 直[中川], 菅生 厚太郎, 永田 英孝, 田川 義晃   Cav1.2とNav1.2の機能亢進変異はマウス大脳皮質において異なる様式で回路形成を障害する  

    日本生理学雑誌  2023.5  (一社)日本生理学会

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Research Projects

  • 神経活動に依存したスクラップアンドビルドによる大脳長距離神経回路の形成

    2019.4 - 2021.3

    科学研究費補助金  新学術領域研究

  • 自発神経活動に依存した大脳長距離軸索投射の形成・再編・再生

    2017.4 - 2019.3

    科学研究費補助金  新学術領域研究

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    2016.7 - 2017.6

    民間企業  国内共同研究 

  • 同期・非同期の自発神経活動による大脳皮質神経回路の形成とその障害

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

  • 哺乳期マウスの神経活動操作・記録実験による生後初期神経活動の役割の解明

    2013.4 - 2015.3

    科学研究費補助金  新学術領域研究

  • 活動依存的メカニズムに基づく大脳皮質長距離軸索投射の再建

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

  • 皮質2/3層興奮性細胞の特徴的な形態・機能獲得における神経活動の役割

    2011.4 - 2013.3

    科学研究費補助金  新学術領域研究

  • 大脳皮質の機能的神経回路の構築原理の解明

    2010.10 - 2016.3

    文部科学省  特色ある大学教育支援プログラム 

    大木研一、田川義晃

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    Grant type:Competitive

  • 大脳皮質の層特異的回路網構築における神経活動の役割

    2009.4 - 2011.3

    科学研究費補助金  若手研究(B)

  • Cross-modal可塑性における代謝型グルタミン酸受容体の役割の解明

    2006.4 - 2009.3

    科学研究費補助金  若手研究(B)

  • 神経ネットワークにおけるグルタミン酸受容体結合蛋白質の役割の解明

    2000.4 - 2001.3

    科学研究費補助金  基盤研究(C)

    田川義晃、金子鋭

  • Cross-modal可塑性における代謝型グルタミン酸受容体の役割の解明

    文部科学省  科学研究費補助金(若手研究(B)) 

    田川 義晃

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  • 神経ネットワークにおけるグルタミン酸受容体結合蛋白質の役割の解明

    文部科学省  科学研究費補助金(基盤研究(C)) 

    田川 義晃

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  • 大脳皮質の層特異的回路網構築における神経活動の役割

    文部科学省  科学研究費補助金(若手研究(B)) 

    田川 義晃

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  • Roles of glutamate receptor binding proteins in synaptic plasticity

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    Grant type:Competitive

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  • Ocular dominance formation and plasticity in mammalian visual system

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    Grant type:Competitive

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  • Functional Roles of Glutamate Receptors in Neural Circuit Formation

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