研究者詳細 - 大岡　唯祐

論文 - 大岡　唯祐

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Fernandes I, Ooka T, Lira D, Martins FH, Orsi H, Jones N, Elias W, Hayashi T, Gomes TA, and Hernandes R. . TccP4: A novel effector identified in the Escherichia albertii strain 1551-2 required for attaching and effacing lesion formation on infected Nck-null cells . Microbiology Spectrum 2025年1月査読国際共著

大岡唯祐、志多田千恵、高橋元秀 . 奄美群島における破傷風菌の分布および株の特性の解析 . 奄美ミッション活動報告書2024 2024年

Mizuno S, Tsukamura Y, Nishio S, Ishida T, Hasegawa D, Kosaka Y, Ooka T, Nishi J, Kasai M. . Catheter-related bloodstream infection caused by Tsukamurella tyrosinosolvens identified by secA1sequencing in an immunocompromised child: a case report. . Annals of Clinical Microbiology and Antimicrobials22 ( 1 ) 97 2023年11月査読

大岡唯祐, 藺牟田直子, 西順一郎, 森田喜紀, 今村真理, 重久朋史, 上野伸広, 相星壮吾, 山本真実, 新川奈緒美, 川村英樹, 馬場洋一, 柿澤広美, 伊藤武, 後藤恭宏, 林哲也 . 2018年のSalmonella enterica serovar Oranienburg菌血症集積事例株と同一クローン由来株による新たな感染事例と各地の食品取り扱い従事者からの同クローンの分離 . 病原微生物検出情報44 127 - 128 2023年8月査読

Koji Ichiki, Tadasuke Ooka, Tetsuhiro Shinkawa, Sakura Inoue, Maiko Hayashida, Daisuke Nakamura, Masaki Akimoto, Makoto Yoshimitsu, Hideki Kawamura, Masatoshi Nakamura, Yuki Obama, Yasuhiro Gotoh, Tetsuya Hayashi, Junichiro Nishi, Kenji Ishitsuka . Genomic and phylogenetic characterization of Elizabethkingia anophelis strains: The first two cases of life-threatening infection in Japan . Journal of infection and chemotherapy29 ( 4 ) 376 - 383 2023年1月査読国際誌

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Elizabethkingia anophelis causes meningitis, bloodstream infections, and respiratory infections in immunocompromised individuals. We examined two E. anophelis strains isolated from the first life-threatening cases caused by this species in Japan to determine the phylogenetic origin and genomic features of them. METHODS: We performed whole genome-based analysis to clarify the genetic relationship for the two strains (EK0004 and EK0079) and Elizabethkingia sp. strains isolated from worldwide and to characterize the genomic features such as the prevalence of virulence- and antimicrobial resistance (AMR)-related genes. PATIENTS: A 29-year-old man with hepatosplenic T-cell lymphoma and a 52-year-old man with systemic lupus erythematosus developed fatal bacteremia and meningitis due to E. anophelis, respectively. RESULTS: Two strains, EK0004 and EK0079, were genetically different but most closely related to the strains isolated from the largest outbreak in Wisconsin, USA from 2015 to 2016, and the strain isolated from cerebrospinal fluid of a patient in Florida, USA in 1982, respectively. The two strains contained AMR-related genes such as those encoding for an extended-spectrum β-lactamase and multiple metallo-β-lactamases and several virulence-related genes such as capsular polysaccharide synthesis gene clusters. CONCLUSIONS: Although further functional analyses are required to understand the virulence of these clones, these finding suggests that enough caution of E. anophelis infection in immunocompromised patients is required since the number of infections by this species is increasing outside Japan.

DOI： 10.1016/j.jiac.2023.01.005

PubMed

Tadasuke Ooka, Yasuhiro Gotoh, Shigeki Hatanaka, Miyuki Yoshimori, Kazutaka Nishitarumizu, Kanami Kojo, Hiroki Kosakamoto, Koji Sameshima, Yoichi Kuroki, Naomi Chibana, Yuriko Doi, Shuji Yoshino, Tetsuya Harada, Kazuko Seto, Tetsuya Ikeda, Hiroaki Miyanohara, Koichiro Nakayama, Mutsuyo Gokuden, Naoko Imuta, Hideki Kawamura, Yoshitoshi Ogura, Tetsuya Hayashi, Junichiro Nishi . A Salmonella enterica serovar Oranienburg clone caused a cluster of bacteremia cases in persons with no recognizable underlying diseases in Japan. . Open Forum Infectious Diseases10 ( 1 ) ofac695 2022年12月査読国際誌

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Salmonella enterica subspecies enterica serovar Oranienburg (SO) is a foodborne pathogen but rarely causes systemic infections such as bacteremia. Between July and September 2018, bacteremia cases caused by SO were identified in 12 persons without any underlying medical conditions in the southern Kyushu area of Japan. METHODS: Randomly amplified polymorphic DNA (RAPD) analysis was performed to investigate the genetic similarity of the 12 bacteremia-related strains and other Japanese isolates. Furthermore, a series of whole-genome sequence (WGS)-based phylogenetic analyses was performed with a global SO strain set (n = 1648). RESULTS: The resolution power of RAPD was insufficient to investigate the genetic similarity between the bacteremia-related strains and other strains. WGS-based phylogenetic analyses revealed that the bacteremia-related strains formed a tight cluster along with 2 strains isolated from asymptomatic carriers in 2018 in the same area, with a maximum within-cluster single-nucleotide polymorphism (SNP) distance of 11. While several strains isolated in the United States and the United Kingdom were found to be closely related to the bacteremia-related strains, 2 strains isolated in 2016 in the southern Kyushu area were most closely related, with SNP distances of 4-11 and 5-10, and had the same plasmids as the bacteremia-related strains. CONCLUSIONS: The 12 bacteremia cases identified were caused by a single SO clone. As none of the bacteremia patients had any underlying diseases, this clone may be prone to cause bacteremia. Although further analyses are required to understand its virulence, particular attention should be given to this clone and its close relatives in the surveillance of nontyphoidal salmonellae.

DOI： 10.1093/ofid/ofac695

PubMed

Sakura Arai, Tadasuke Ooka, Mizuha Shibata, Yuhki Nagai, Yuki Tokoi, Hiromi Nagaoka, Rika Maeda, Akihiko Tsuchiya, Yuka Kojima, Kenji Ohya, Takahiro Ohnishi, Noriko Konishi, Kayoko Ohtsuka, Yukiko Hara-Kudo . Development of a novel real-time polymerase chain reaction assay to detect Escherichia albertii in chicken meat . Foodborne Pathogens and Disease19 ( 12 ) 823 - 829 2022年12月査読国際誌

Koji Nakae, Tadasuke Ooka, Koichi Murakami, Yukiko Hara-Kudo, Naoko Imuta, Yasuhiro Gotoh, Yoshitoshi Ogura, Tetsuya Hayashi, Yasuhiro Okamoto, and Junichiro Nishi . Diversification of Escherichia albertii H-antigens and development of H-Genotyping PCR . Frontiers in Microbiology12 737979 - 737979 2021年11月査読国際誌

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Escherichia albertii is a recently recognized human enteropathogen that is closely related to Escherichia coli. As E. albertii sometimes causes outbreaks of gastroenteritis, rapid strain typing systems, such as the O- and H-serotyping systems widely used for E. coli, will be useful for outbreak investigation and surveillance. Although an O-genotyping system has recently been developed, the diversity of E. albertii H-antigens (flagellins) encoded by fliC genes remains to be systematically investigated, and no H-serotyping or genotyping system is currently available. Here, we analyzed the fliC genes of 243 genome-sequenced E. albertii strains and identified 73 sequence types, which were grouped into four clearly distinguishable types designated E. albertii H-genotypes 1-4 (EAHg1-EAHg4). Although there was a clear sign of intraspecies transfer of fliC genes in E. albertii, none of the four E. albertii H-genotypes (EAHgs) were closely related to any of the 53 known E. coli H-antigens, indicating the absence or rare occurrence of interspecies transfer of fliC genes between the two species. Although the analysis of more E. albertii strains will be required to confirm the low level of variation in their fliC genes, this finding suggests that E. albertii may exist in limited natural hosts or environments and/or that the flagella of E. albertii may function in a limited stage(s) in their life cycle. Based on the fliC sequences of the four EAHgs, we developed a multiplex PCR-based H-genotyping system for E. albertii (EAH-genotyping PCR), which will be useful for epidemiological studies of E. albertii infections.

DOI： 10.3389/fmicb.2021.737979

PubMed

八尋俊輔, 原田誠也, 小原敦美, 藺牟田直子, 大岡唯祐, 西順一郎 . 熊本県におけるβ-ラクタム系薬耐性腸内細菌目細菌の保菌状況調査（2015年4月～2020年3月） . 感染症学雑誌97 ( 5 ) 153 - 161 2023年9月査読

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本感染症学会

熊本県におけるβ-ラクタム系薬耐性腸内細菌目細菌（β-lactam antibiotics-resistant Enterobacterales；BLARE）の腸管内保菌状況を把握するため，2015年4月～2020年3月間に当所に搬入された糞便1,434検体から菌分離を試みたところ，340検体（23.7%）から354株のBLAREが分離された．このうち343株（96.9%）は大腸菌であり，ESBL産生大腸菌が305株（86.2%）を占めた．さらに，その中の133株（43.6%）は世界的な拡散が報告されているパンデミック・クローン群の大腸菌O25b-ST131と判定されたことから，このクローン群の拡大が熊本県における薬剤耐性菌腸管内保菌率増加の一因であることが示唆された．なお，分離されたESBL産生菌はすべてCTX-M型遺伝子保有株であり，CTX-M-9 groupが210株（67.7%），CTX-M-1 groupが80株（25.8%），およびCTX-M1とCTX-M-9の両group保有株が13株（4.2%）などであった．また，分離株を検査対象施設の大まかな種類別に集計したところ，乳幼児施設での分離率が35%を超え，複数の施設でESBL産生大腸菌の水平伝播が確認されたことから，乳幼児施設はBLAREのリザーバーの一つである可能性が高いと思われた．

DOI： 10.11150/kansenshogakuzasshi.e21037

Hideki Kawamura, Naoko Imuta, Tadasuke Ooka, Akari Shigemi, Masatoshi Nakamura, Kimiko Mougi, Yuki Obama, Ryuko Fukuyama, Syoko Arimura, Nao Murata, Hiroyuki Tominaga, Hiromi Sasaki, Satoshi Nagano, Noboru Taniguchi, Junichiro Nishi . Impact of control measures including decolonization and hand hygiene for orthopaedic surgical site infection caused by methicillin-resistant Staphylococcus aureus at a Japanese tertiary-care hospital: evaluation of the transmission process by epidemiological and molecular analyses. . Journal of Hospital InfectionS0195-6701(23) 00240-2 2023年7月査読

Keiji Nakamura, Kazuko Seto, Kenichi Lee, Tadasuke Ooka, Yasuhiro Gotoh, Itsuki Taniguchi, Yoshitoshi Ogura, Jacques Georges Mainil, Denis Piérard, Tetsuya Harada, Yoshiki Etoh, Saori Ueda, Mitsuhiro Hamasaki, Junko Isobe, Keiko Kimata, Hiroshi Narimatsu, Jun Yatsuyanagi, Makoto Ohnishi, Sunao Iyoda, Tetsuya Hayashi . Global population structure, genomic diversity and carbohydrate fermentation characteristics of clonal complex 119 (CC119), an understudied Shiga toxin-producing E. coli (STEC) lineage including O165:H25 and O172:H25. . Microbial Genomics9 ( 3 ) 000959 2023年3月査読国際共著国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Microbiology Society

<jats:p>Among Shiga toxin (Stx)-producing <jats:italic>
<jats:named-content content-type="species">
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.3093" xlink:type="simple">Escherichia coli</jats:ext-link>
</jats:named-content>
</jats:italic> (STEC) strains of various serotypes, O157:H7 and five major non-O157 STEC (O26:H11, O111:H8, O103:H2, O121:H19 and O145:H28) can be selectively isolated by using tellurite-containing media. While human infections by O165:H25 STEC strains have been reported worldwide, their detection and isolation are not easy, as they are not resistant to tellurite. Systematic whole-genome sequencing (WGS) analyses have not yet been conducted. Here, we defined O165:H25 strains and their close relatives, including O172:H25 strains, as clonal complex 119 (CC119) and performed a global WGS analysis of the major lineage of CC119, called CC119 <jats:italic>sensu stricto</jats:italic> (CC119ss), by using 202 CC119ss strains, including 90 strains sequenced in this study. Detailed comparisons of 13 closed genomes, including 7 obtained in this study, and systematic analyses of Stx phage genomes in 50 strains covering the entire CC119ss lineage, were also conducted. These analyses revealed that the Stx2a phage, the locus of enterocyte effacement (LEE) encoding a type III secretion system (T3SS), many prophages encoding T3SS effectors, and the virulence plasmid were acquired by the common ancestor of CC119ss and have been stably maintained in this lineage, while unusual exchanges of Stx1a and Stx2c phages were found at a single integration site. Although the genome sequences of Stx2a phages were highly conserved, CC119ss strains exhibited notable variation in Stx2 production levels. Further analyses revealed the lack of SpLE1-like elements carrying the tellurite resistance genes in CC119ss and defects in rhamnose, sucrose, salicin and dulcitol fermentation. The genetic backgrounds underlying these defects were also clarified.</jats:p>

DOI： 10.1099/mgen.0.000959

Yusuke Nomoto, Yuko Higashi, Youhei Uchida, Kazuyasu Fujii, Tadasuke Ooka, Takuro Kanekura . Disseminated cutaneous sporotrichosis with intravascular granuloma . The Journal of Dermatology49 ( 9 ) 301 - 302 2022年9月査読

Ruriko Nishida, Keiji Nakamura, Itsuki Taniguchi, Kazunori Murase, Tadasuke Ooka, Yoshitoshi Ogura, Yasuhiro Gotoh, Takehiko Itoh, Atsushi Toyoda, Jacques Georges Mainil, Denis Piérard, Kazuko Seto, Tetsuya Harada, Junko Isobe, Keiko Kimata, Yoshiki Etoh, Mitsuhiro Hamasaki, Hiroshi Narimatsu, Jun Yatsuyanagi, Mitsuhiro Kameyama, Yuko Matsumoto, Yuhki Nagai, Jun Kawase, Eiji Yokoyama, Kazuhiko Ishikawa, Takayuki Shiomoto, Kenichi Lee, Dongchon Kang, Koichi Akashi, Makoto Ohnishi, Sunao Iyoda and Tetsuya Hayashi . The global population structure and evolutionary history of the acquisition of major virulence factor-encoding genetic elements in Shiga toxin-producing Escherichia coli O121:H19 . Microbial Genomics7 ( 12 ) 000716 2021年12月査読国際共著国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）

Shiga toxin (Stx)-producing Escherichia coli (STEC) are foodborne pathogens causing serious diseases, such as haemorrhagic colitis and haemolytic uraemic syndrome. Although O157:H7 STEC strains have been the most prevalent, incidences of STEC infections by several other serotypes have recently increased. O121:H19 STEC is one of these major non-O157 STECs, but systematic whole genome sequence (WGS) analyses have not yet been conducted on this STEC. Here, we performed a global WGS analysis of 638 O121:H19 strains, including 143 sequenced in this study, and a detailed comparison of 11 complete genomes, including four obtained in this study. By serotype-wide WGS analysis, we found that O121:H19 strains were divided into four lineages, including major and second major lineages (named L1 and L3, respectively), and that the locus of enterocyte effacement (LEE) encoding a type III secretion system (T3SS) was acquired by the common ancestor of O121:H19. Analyses of 11 complete genomes belonging to L1 or L3 revealed remarkable interlineage differences in the prophage pool and prophage-encoded T3SS effector repertoire, independent acquisition of virulence plasmids by the two lineages, and high conservation in the prophage repertoire, including that for Stx2a phages in lineage L1. Further sequence determination of complete Stx2a phage genomes of 49 strains confirmed that Stx2a phages in lineage L1 are highly conserved short-tailed phages, while those in lineage L3 are long-tailed lambda-like phages with notable genomic diversity, suggesting that an Stx2a phage was acquired by the common ancestor of L1 and has been stably maintained. Consistent with these genomic features of Stx2a phages, most lineage L1 strains produced much higher levels of Stx2a than lineage L3 strains. Altogether, this study provides a global phylogenetic overview of O121:H19 STEC and shows the interlineage genomic differences and the highly conserved genomic features of the major lineage within this serotype of STEC.

DOI： 10.1099/mgen.0.000716

PubMed

Sakura Arai, Satoko Yamaya, Kayoko Ohtsuka, Noriko Konishi, Hiromi Obata, Tadasuke Ooka, Shouhei Hirose, Akemi Kai, Yukiko Hara-Kudo . Detection of Escherichia albertii in retail oysters . Journal of Food Protection 2021年9月査読

Nguyen Thi Thu Huong, Atsushi Iguchi, Ritsuko Ohata, Hisahiro Kawai, Tadasuke Ooka, Hiroshi Nakajima, Sunao Iyoda . Distribution of novel Og-types in Shiga toxin-producing Escherichia coli isolated from healthy cattle . Journal of Clinical Microbiology59 ( 3 ) e02624-20 2020年12月査読

Ja-Young Lee, Hidehisa Shimizu, Masahito Hagio, Satoru Fukiya, Masamichi Watanabe, Yasutake Tanaka, Ga-Hyun Joe, Hitoshi Iwaya, Reika Yoshitsugu, Keidai Kikuchi, Misaki Tsuji, Nanako Baba, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Akari Takeuchi, Yumiko Furukawa, Bungo Shirouchi, Masao Sato, Tadasuke Ooka, Yoshitoshi Ogura, Tetsuya Hayashi, Atsushi Yokota, and Satoshi Ishizuka . 12α-hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats . BBA Molecular and Cell Biology of Lipids1865 ( 12 ) 158811 2020年12月査読

Fabiano T Romão, Fernando Henrique Martins, Rodrigo Tavanelli Hernandes, Tadasuke Ooka, Fernanda Fernandes Dos Santos, Denise Yamamoto, Alexis Bonfim-Melo, Tetsuya Hayashi, Waldir P Elias, Vanessa Sperandio, Tânia Aparecida Tardelli Gomes . Genomic properties and temporal analysis of the interaction of an invasive Escherichia albertii with epithelial cells . Frontiers Cellular and Infection Microbiology10 571088 2020年12月査読

上村晃秀, 眞鍋佳月, 山本真実, 岩切忠文, 濱田結花, 本田俊郎, 川村英樹, 藺牟田直子, 大岡唯祐, 西順一郎 . 薬剤耐性菌検索体制の整備に関する研究(第III報) . 鹿児島県環境保健センター所報 ( 21 ) 65 - 68 2020年12月

佐藤空見子，永井章子，小原準，遠藤千春，林哲也，大岡唯祐，瀬戸順次，村上光一 . 山形県内と畜場搬入豚のEscherichia albertii保菌状況及びその疫学的特徴 . 日本獣医師会雑誌73 ( 5 ) 265 - 273 2020年6月査読

Tetsuya Ikeda, Toshie Shinagawa, Takuya Ito, Yuta Ohno, Akiko Kubo, Junichiro Nishi, Yasuhiro Gotoh, Yoshitoshi Ogura, Tadasuke Ooka, Tetsuya Hayashi . Hypoosmotic stress induces flagellar biosynthesis and swimming motility in Escherichia albertii. . Communications Biology3 87 2020年2月査読

Keiji Nakamura, Kazunori Murase, Mitsuhiko P Sato, Atsushi Toyoda, Takehiko Itoh, Jacques Georges Mainil, Denis Piérard, Shuji Yoshino, Keiko Kimata, Junko Isobe, Kazuko Seto, Yoshiki Etoh, Hiroshi Narimatsu, Shioko Saito, Jun Yatsuyanagi, Kenichi Lee, Sunao Iyoda, Makoto Ohnishi, Tadasuke Ooka, Yasuhiro Gotoh, Yoshitoshi Ogura, Tetsuya Hayashi . Differential dynamics and impacts of prophages and plasmids on the pangenome and virulence factor repertoires of STEC O145:H28 . Microbial Genomics 2020年1月査読

Toshiaki Kawabata, Yoichi Tenokuchi, Hiroki Yamakuchi, Hirotsugu Sameshima, Hirosuke Katayama, Takeshi Ota, Masatomo Tokunaga, Tomoko Takezaki, Suehiro Tamae, Toru Nakamura, Bin Chang, Yuichi Kodama, Naoko Imuta, Tadasuke Ooka, Yasuhiro Okamoto, Shigeru Suga, Junichiro Nish . Concurrent Bacteremia Due to Non-vaccine Serotype 24F Pneumococcus in Twins: A Rapid Increase in Serotype 24F-invasive Pneumococcal Disease and its High Invasive Potential. . The Pediatric Infectious Disease Journal39 ( 1 ) 85 - 87 2020年1月査読

Kentaro Kasama, Hiromi Fujita, Seigo Yamamoto, Tadasuke Ooka, Yasuhiro Gotoh, Yoshitoshi Ogura, Shuji Ando, and Tetsuya Hayashi . Genomic features of Rickettsia heilongjiangensis revealed by intraspecies comparison and detailed comparison with Rickettsia japonica. . Frontiers in Microbiology10 2787 2019年12月査読

Toshinobu Imashioya, Yuichi Kodama, Tadasuke Ooka, Shunsuke Nakagawa, Takuro Nishikawa, Takayuki Tanabe, Yasuhiro Okamoto, Naoko Imuta, Mari Kirishima, Akihide Tanimoto, Toyoyasu Koriyama, Junichiro Nishi, Yoshifumi Kawano . Liver abscess due to Sterigmatomyces halophilus in a boy with acute lymphoblastic leukemiaSterigmatomyces halophilus . Journal of Infection and Chemotherapy25 ( 12 ) 1047 - 1049 2019年12月査読

Tadasuke Ooka, Kazuko Seto, Yoshitoshi Ogura, Keiji Nakamura, Atsushi Iguchi, Yasuhiro Gotoh, Mikiko Honda, Yoshiki Etoh, Tetsuya Ikeda, Wakana Sugitani, Takayuki Konno, Kimiko Kawano, Naoko Imuta, Kiyotaka Yoshiie, Yukiko Hara-Kudo, Koichi Murakami, Tetsuya Hayashi, Junichiro Nishi . O-antigen biosynthesis gene clusters of Escherichia albertii: their diversity and similarity to E. coli gene clusters and the development of an O-genotyping method. . Microbial Genomics 2019年11月査読

Kanako Masuda, Tadasuke Ooka, Hiroko Akita, Takahiro Hiratsuka, Shinichi Takao, Mami Fukada, Kaori Inoue, Mikiko Honda, Junko Toda, Wakana Sugitani, Hiroshi Narimatsu, Taisei Ishioka, Shinichiro Hirai, Tsuyoshi Sekizuka, Makoto Kuroda, Yukio Morita, Tetsuya Hayashi, Hirokazu Kimura, Kazunori Oishi, Makoto Ohnishi, Shuji Fujimoto, Koichi Murakami . Epidemiological Aspects of Escherichia albertii Outbreaks in Japan and Genetic Characteristics of the Causative Pathogen. . Foodborne Pathogens and Disease17 ( 2 ) 144 - 150 2019年10月招待査読

Yoko Arimizu, Yumi Kirino, Mitsuhiko P. Sato, Koichi Uno, Toshio Sato, Yasuhiro Gotoh, Frédéric Auvray, Hubert Brugere, Eric Oswald, Jacques G. Mainil, Kelly S. Anklam, Dörte Döpfer, Shuji Yoshino, Tadasuke Ooka, Yasuhiro Tanizawa, Yasukazu Nakamura, Atsushi Iguchi, Tomoko Morita-Ishihara, Makoto Ohnishi, Koichi Akashi, Tetsuya Hayashi, Yoshitoshi Ogura . Large-scale genome analysis of bovine commensal Escherichia coli revealed that bovine-adapted E. coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains . Genome Research29 ( 9 ) 1495 - 1505 2019年8月査読

畠中成己、吉森みゆき、西垂水和隆、岩元ゆかり、小坂元博揮、鮫島幸二、古城圭馴美、内門　一、奥　章三、黒木暢一、松浦良樹、知花なおみ、上地修裕、田中直子、山下淳一、土井由利子、外城秀己、和田香織、下原美智子、宇田英典、吉野修司、宮原聖奈、杉本貴之、中山浩一郎、御供田睦代、大坪充寛、後藤恭宏、小椋義俊、林　哲也、川村英樹、藺牟田直子、大岡唯祐、西　順一郎 . 鹿児島市を中心としたSalmonella enterica serovar Oranienburg 菌血症の集積 . 病原微生物検出情報40 ( 5 ) 91 - 92 2019年5月査読

Mauricio P. Lima, Denise Yamamoto, Ana Carolina de Mello Santos, Tadasuke Ooka, Rodrigo T. Hernandes, Mônica A. M. Vieira, Fernanda Fernandes dos Santos, Rosa Maria Silva, Tetsuya Hayashi, and Tânia A. T. Gomes . Phenotypic characterization and virulence-related properties of Escherichia albertii strains isolated from children with diarrhea in Brazil. . Pathogens and DIsease77 ( 2 ) ftz014 2019年3月査読

Kazue Nakanaga, Yoshitoshi Ogura, Atsushi Toyoda, Mitsunori Yoshida, Hanako Fukano, Nagatoshi Fujiwara, Yuji Miyamoto, Noboru Nakata, Yuko Kazumi, Shinji Maeda, Tadasuke Ooka, Kazunari Tanigawa, Masamichi Goto, Satoshi Mitarai, Koichi Suzuki, Norihisa Ishii, Manabu Ato, Tetsuya Hayashi, and Yoshihiko Hoshino . Naturally occurring a loss of a giant plasmid from Mycobacterium ulcerans subsp. shinshuense makes it non-pathogenic. . Scientific Reports8 ( 1 ) 8218 2018年5月査読

Fabiano Romão, Rodrigo Hernandes, Tadasuke Ooka, Tetsuya Hayashi, Vanessa Sperandio, and Tania Gomes . Complete Genome Sequence of Escherichia albertii Strain 1551-2, a Potential Extra and Intracellular Pathogen . Genome announcements6 ( 9 ) e00075-18 2018年3月査読

Yoshitoshi Ogura, Yasuhiro Gotoh, Takehiko Itoh, Mitsuhiko P. Sato, Kazuko Seto, Shyuji Yoshino, Junko Isobe, Yoshiki Etoh, Mariko Kurogi, Keiko Kimata, Eriko Maeda, Denis Piérard, Masahiro Kusumoto, Masato Akiba, Kiyoshi Tominaga, Yumi Kirino, Yuki Kato, Katsuhiko Shirahige, Tadasuke Ooka, Nozomi Ishijima, Ken-ichi Lee, Sunao Iyoda, Jacques Georges Mainil, Tetsuya Hayashi . Population structure of Escherichia coli O26 : H11 with recent and repeated stx2 acquisition in multiple lineages. . Microbial Genomics3 2017年11月査読

Yohsuke Ogawa, Kazumasa Shiraiwa, Yoshitoshi Ogura, Tadasuke Ooka, Sayaka Nishikawa, Masahiro Eguchi, Tetsuya Hayashi, Yoshihiro Shimoji . Clonal Lineages of Erysipelothrix rhusiopathiae Responsible for Acute Swine Erysipelas in Japan Identified by Using Genome-Wide Single-Nucleotide Polymorphism Analysis. . Applied and Environmental Microbiology83 ( 11 ) e00130-17 2017年5月査読

Arzuba Akter, Tadasuke Ooka, Yasuhiro Gotoh, Seigo Yamamoto, Hiromi Fujita, Fumio Terasoma, Kouji Kida, Masakatsu Taira, Fumiko Nakadouzono, Mutsuyo Gokuden, Manabu Hirano, Mamoru Miyashiro, Kouichi Inari, Yukie Shimazu, Kenji Tabara, Atsushi Toyoda, Dai Yoshimura, Takehiko Itoh, Tomokazu Kitano, Mitsuhiko P. Sato, Keisuke Katsura, Shakhinur Islam Mondal, Yoshitoshi Ogura, Shuji Ando, Tetsuya Hayashi . Extremely low genomic diversity of Rickettsia japonica distributed in Japan . Genome Biology and Evolution9 ( 1 ) 124 - 133 2016年12月査読

Shakhinur Mondal, Md Islam, Akira Sawaguchi, Md Asadulghani, Tadasuke Ooka, Yasuhiro Gotoh, Yasuhiro Kasahara, Yoshitoshi Ogura, and Tetsuya Hayashi . Genes essential for the morphogenesis of the Shiga toxin 2-transducing phage from Escherichia coli O157:H7 . Scientific Reports6 39036 2016年12月査読

Mitsunori Yoshida, Kazue Nakanaga, Yoshitoshi Ogura, Atsushi Toyoda, Tadasuke Ooka, Yuko Kazumi, Satoshi Mitarai, Norihisa Ishii, Tetsuya Hayashi, Yoshihiko Hoshino . The complete Genome Sequence of Mycobacterium " shinshuense ", a subspecies of M. ulcerans . Genome Announcements 2016年8月査読

Naoko Imuta, Tadasuke Ooka, Kazuko Seto, Ryuji Kawahara, Toyoyasu Koriyama, Tsuyoshi Kojyo, Atsushi Iguchi, Koichi Tokuda, Hideki Kawamura, Kiyotaka Yoshiie, Yoshitoshi Ogura, Tetsuya Hayashi, and Junichiro Nishi . Phylogenetic analysis of enteroaggregative Escherichia coli (EAEC) isolated in Japan revealed the emergence of CTX-M-14-producing EAEC O25:H4 clones related to ST131 . Journal of Clinical Microbiology 2016年6月査読

村上光一, 伊豫田淳, 大西真, 深田真美, 増田加奈子, 前田詠里子, 麻生嶋七美, 成松浩志, 緒方喜久代, 戸田純子, 原田誠也, 大岡唯祐, 林哲也　他 . Vero毒素産生株が散見される新興感染症原因菌 Escherichia albertiiについて . 病原微生物検出情報 (IASR)37 ( 5 ) 98 - 100 2016年5月招待

Bruna G. Garcia, Tadasuke Ooka, Yasuhiro Gotoh, Mônica A.M. Vieira, Denise Yamamoto, Yoshitoshi Ogura, Dennys M. Girão, Suely C.F. Sampaio, Alexis Bonfim Melo, Kinue Irino, Tetsuya Hayashi, Tânia A.T. Gomes . Genetic relatedness and virulence properties of enteropathogenic Escherichia coli strains of serotype O119:H6 expressing localized adherence or localized and aggregative adherence-like patterns on HeLa cells . International Journal of Medical Microbiology306 152 - 164 2016年2月査読

Tadasuke Ooka, Yoshitoshi Ogura, Keisuke Katsura, Kazuko Seto, Hideki Kobayashi, Kimiko Kawano, Eisuke Tokuoka, Masato Furukawa, Seiya Harada, Shuji Yoshino, Junji Seto, Tetsuya Ikeda, Keiji Yamaguchi, Kazunori Murase, Yasuhiro Gotoh, Naoko Imuta, Junichiro Nishi, Tânia A Gomes, Lothar Beutin, Tetsuya Hayashi . Defining the genome features of Escherichia albertii, an emerging enteropathogen closely related to Escherichia coli. . Genome Biology and Evolution7 ( 12 ) 3170 - 3179 2015年12月査読

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford Journals

Escherichia albertii is a recently recognized close relative of E. coli. This emerging enteropathogen possesses a type III secretion system (T3SS) encoded by the locus of enterocyte effacement (LEE), similar to enteropathogenic and enterohemorrhagic E. coli (EPEC and EHEC). Shiga toxin-producing strains have also been identified. The genomic features of E. albertii, particularly differences from other Escherichia species, have not yet been well clarified. Here, we sequenced the genome of 29 E. albertii strains (3 complete and 26 draft sequences) isolated from multiple sources and performed intra-species and intra-genus genomic comparisons. The sizes of the E. albertii genomes range from 4.5 Mb to 5.1 Mb, smaller than those of E. coli strains. Intra-species genomic comparisons identified five phylogroups of E. albertii. Intra-genus genomic comparison revealed that the possible core genome of E. albertii comprises 3,250 genes, whereas that of the genus Escherichia comprises 1,345 genes. Our analysis further revealed several unique or notable genetic features of E. albertii, including those responsible for known biochemical features and virulence factors and a possibly active second T3SS known as ETT2 (E. coli T3SS 2) that is inactivated in E. coli. Although this organism has been observed to be non-motile in vitro, genes for flagellar biosynthesis are fully conserved; chemotaxis-related genes have been selectively deleted. Based on these results, we have developed a nested PCR system to directly detect E. albertii. Our data define the genomic features of E. albertii and provide a valuable basis for future studies of this important emerging enteropathogen.

DOI： 10.1093/gbe/evv211

Yoshitoshi Ogura, Shakhinur Islam Mondal, Md Rakibul Islam, Toshihiro Mako, Kokichi Arisawa, Keisuke Katsura, Tadasuke Ooka, Yasuhiro Gotoh, Kazunori Murase, Makoto Ohnishi, and Tetsuya Hayashi . The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage . Scientific Reports5 16663 2015年11月査読

Masahiro Kusumoto, Dai Fukamizu, Yoshitoshi Ogura, Eiji Yoshida, Fumiko Yamamoto, Taketoshi Iwata, Tadasuke Ooka, Masato Akiba, Tetsuya Hayashi . The lineage-specific distribution of IS-excision enhancer in enterotoxigenic Escherichia coli isolated from swine. . Applied and Environmental Microbiology80 ( 4 ) 1394 - 1402 2014年2月査読

Atsushi Hinenoya, Kensuke Shima, Masahiro Asakura, Kazuhiko Nishimura, Teizo Tsukamoto, Tadasuke Ooka, Tetsuya Hayashi, T. Ramamurthy, S. Faruque, Shinji Yamasaki . Molecular characterization of cytolethal distending toxin gene-positive Escherichia coli from healthy cattle and swine in Nara, Japan. . BMC Microbiology14 97 - 97 2014年査読

Koichi Murakami, Yoshiki Etoh, Eriko Tanaka, Sachiko Ichihara, Kazumi Horikawa, Kimiko Kawano, Tadasuke Ooka, Yoshiaki Kawamura, Kenichiro Ito . Shiga toxin 2f-producing Escherichia albertii from a symptomatic human. . Japanese Journal of Infectious Diseases67 204 - 208 2014年査読

Atsushi Iguchi, Y. Nagaya, E. Pradel, Tadasuke Ooka, Yoshitoshi Ogura, K.Katsura, Ken Kurokawa, Kenshiro Oshima, Masahira Hattori, Julian Parkhill, M. Sebaihia, S. Coulthurst, N. Gotoh, N.R. Thomson, J.J. Ewbank, Tetsuya Hayashi . Genome evolution and plasticity of Serratia marcescens, an important multidrug resistant nosocomial pathogen. . Genome Biology and Evolution6 ( 8 ) 2096 - 2110 2014年査読

Tadasuke Ooka, Eisuke Tokuoka, Masato Furukawa, Tetsuya Nagamura, Yoshitoshi Ogura, Kokichi Aisawa, Seiya Harada, Tetsuya Hayashi . Human gastroenteritis outbreak associated with Escherichia albertii, Japan. . Emerging Infectious Diseases19 ( 1 ) 144 - 146 2013年査読

Tadasuke Ooka, Kazuko Seto, Kimiko Kawano, Hideki Kobayashi, Yoshiki Etoh, Sachiko Ichihara, Akiko Kaneko, Junko Isobe, Keiji Yamaguchi, Kazumi Horikawa, Tania Gomes, Annik Linden, Marjorie Bardiau, Jacques Mainil, Lothar Beutin, Yoshitoshi Ogura, Tetsuya Hayashi . Clinical significance of Escherichia albertii. . Emerging Infectious Diseases18 ( 3 ) 488 - 492 2012年3月査読

Kazunori Murase, Tadasuke Ooka, Atsushi Iguchi, Yoshitoshi Ogura, Keisuke Nakayama, Md. Asadulghani, Md. R. Islam, Hirotaka Hiyoshi, Toshio Kodama, L. Beutin, Tetsuya Hayashi . Hemolysin E- and enterohemolysin-derived hemolytic activity of O55/O157 strains and other Escherichia coli lineages. . Microbiology158 746 - 758 2012年3月査読

Md. R. Islam, Yoshitoshi Ogura, Md. Asdulghani, Tadasuke Ooka, Kazunori Murase, Yasuhiro Gotoh, Tetsuya Hayashi . A sensitive and simple plaque formation method for the Stx2 phage of Escherichia coli O157:H7, which does not form plaques in the standard plating procedure. . Plasmid67 ( 3 ) 227 - 235 2012年1月査読

Naoko Saito, Ayumi Hida, Yuri Koide, Tadasuke Ooka, Yaeko Ichikawa, Jun Shimizu, Akitake Mukasa, Hirofumi Nakatomi, Shuji Hatakeyama, Tetsuya Hayashi, Shoji Tsuji . Culture-negative brain abscess with Streptococcus intermedius infection with diagnosis established by direct nucleotide sequence analysis of the 16S ribosomal RNA gene. . Internal Medicine51 ( 2 ) 211 - 216 2012年1月査読

Atsushi Yokota, Satoru Fukiya, Tadasuke Ooka, Yoshitoshi Ogura, Tetsuya Hayashi, Satoshi Ishizuka . Is bile acid a determinant of the gut microbiota on a high-fat diet? . Gut Microbes3 ( 5 ) 455 - 459 2012年査読

K.B.M. Saiful Islam , Satoru Fukiya, Masahito Hagio, Nobuyuki Fujii, Satoshi Ishizuka, Tadasuke Ooka, Yoshitoshi Ogura, Tetsuya Hayashi, Atsushi Yokota . Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. . Gastroenterology141 ( 5 ) 1773 - 1781 2011年10月査読

Jacques G. Mainil, Marjorie Bardiau, Tadasuke Ooka, Yoshitoshi Ogura, Kazunori Murase, Yoshiki Etoh, Sachiko Ichihara, Kazumi Horikawa, G. Buvens, D. Pierard, Takehiko Itoh, Tetsuya Hayashi . IS621-based multiplex PCR printing method of O26 enterohaemorrhagic and enteropathogenic Escherichia coli isolated from humans and cattle. . Journal of Applied Microbiology111 773 - 786 2011年9月査読

Yohsuke Ogawa, Tadasuke Ooka, Fang Shi, Yoshitoshi Ogura, Keisuke Nakayama, Tetsuya Hayashi, Yoshihiko Shimoji . The genome of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, reveals new insights into the evolution of Firmicutes and the organism's intracellular adaptations. . Journal of Bacteriology193 ( 12 ) 2959 - 2971 2011年6月査読

Masahiro Kusumoto, Tadasuke Ooka, Yosuke Nishiya, Yoshitoshi Ogura, Takashi Saito, Yasuhiko Sekine, Taketoshi Iwata, Masato Akiba, Tetsuya Hayashi . IS-excision enhancer removes transposable elements from bacterial genomes and induces various genomic deletions. . Nature Communication2 152 2011年査読

Tomomi Kuwahara, Yoshitoshi Ogura, Kenshiro Oshima, Ken Kurokawa, Tadasuke Ooka, Hideki Hirakawa, Takehiko Itoh, Haruyuki Nakayama-Imaohji, Minoru Ichimura, Kikuji Itoh, Chieko Ishifune, Yoichi Maekawa, Koji Yasutomo, Masahira Hattori, Tetsuya Hayashi . The lifestyle of the segmented filamentous bacterium: a nonculturable gut-associated immunostimulating microbe inferred by whole-genome sequencing. . DNA Research18 293 - 301 2011年査読

Hilo Yen, Tadasuke Ooka, Atsushi Iguchi, Tetsuya Hayashi, Nakaba Sugimoto, Toru Tobe . NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA. . PLoS Pathogen6 ( 12 ) e1001 231 2010年12月査読

Takahisa Yano, Kyaw Kyaw Moe, Kazuko Yamazaki, Tadasuke Ooka, Tetsuya Hayashi, Naoaki Misawa . Identification of candidate pathogens of papillomatous digital dermatitis in dairy cattle from quantitative 16S rRNA clonal analysis. . Veterinary Microbiology134 352 - 362 2010年7月査読

Yoshitoshi Ogura, Tadasuke Ooka, Atsushi Iguchi, Hidehiro Toh, Md. Asadulghani, Kenshiro Oshima, Toshio Kodama, Hiroyuki Abe, Keisuke Nakayama, Ken Kurokawa, Toru Tobe, Masahira Hattori, Tetsuya Hayashi . Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli. . Proceedings of the National Academy of Sciences106 ( 42 ) 17939 - 17944 2009年10月査読

Tadasuke Ooka, Jun Terajima, Masahiro Kusumoto, Atsushi Iguchi, Ken Kurokawa, Yoshitoshi Ogura, Asadulghani, Keisuke Nakayama, Kazunori Murase, Makoto Ohnishi, Sunao Iyoda, Haruo Watanabe, Tetsuya Hayashi . Development of a multiplex PCR-based rapid typing method for enterohemorrhagic Escherichia coli O157 strains. . Journal of Clinical Microbiology47 ( 9 ) 2888 - 2894 2009年9月査読

Tadasuke Ooka, Yoshitoshi Ogura, Asadulghani, Makoto Ohnishi, Keisuke Nakayama, Jun Terajima, Haruo Watanabe, Tetsuya Hayashi . Inference of the impact of insertion sequence (IS) elements on bacterial genome diversification through analysis of small-size structural polymorphisms in Escherichia coli O157 genomes. . Genome Research19 1809 - 1816 2009年6月査読

Md. Asadulghani, Yoshitoshi Ogura, Tadasuke Ooka, Takehiko Itoh, Akira Sawaguchi, Atsushi Iguchi, Keisuke Nakayama, Tetsuya Hayashi . The defective prophage pool of Escherichia coli O157: prophage-prophage interactions potentiate horizontal transfer of virulence determinants. . Plos Pathogens5 ( 5 ) e1000408 2009年5月査読

Atsushi Iguchi, N.R. Thomson, Yoshitoshi Ogura, D. Saunders, Tadasuke Ooka, I.R. Henderson, D. Harris, Asadulghani, Ken Kurokawa, P. Dean, B. Kenny, M.A. Quail, S. Thurston, G. Dougan, Tetsuya Hayashi, J. Parkhill, G. Frankel . The complete genome sequence and comparative genome analysis of enteropathogenic E. coli O127:H6 strain E2348/69. . Journal of Bacteriology191 ( 1 ) 347 - 354 2009年1月査読

E. Loukiadis, Rika Nobe, S. Herold, C. Tramuta, Yoshitoshi Ogura, Tadasuke Ooka, S. Morabito, M. Kerouredan, H. Brugere, H. Schmidt, Tetsuya Hayashi, E. Oswald . Distribution, functional expression genetic organization of Cif, a phage-encoded type III-secreted effector from enteropathogenic and enterohaemorragic Escherichia coli. . Journal of Bacteriology190 ( 1 ) 275 - 285 2008年1月査読

L. Bai, S. Schukker, A. Whale, A. Mousnier, O. Marches, L. Wang, Tadasuke Ooka, R. Heuschkel, J.B. Kaper, T.S.K. Gomes, J. Xu, A.D. Phillips, G. Frankel . Enteropathogenic Escherichia coli (EPEC) O125:H6 triggers attaching and effacing lesions on human intestinal biopsies independently of Nck. . Infection and Immunity76 ( 1 ) 361 - 368 2008年1月査読

Tadasuke Ooka, Vieira MA, Yoshitoshi Ogura, Beutin L, Ragione RL, P. M. van Diemen, Stevens MP, Aktan I, Cawthraw S, Best A, Hernandes RT, Krause G, Gomes TA, Tetsuya Hayashi T, Frankel G . Characterization of tccP2 carried by atypical enteropathogenic Escherichia coli. . FEMS Microbiology Letters271 126 - 135 2007年査読

Yoshitoshi Ogura, Tadasuke Ooka, Asadulghani, Jun Terajima, J-P. Nougayrede, Ken Kurokawa, Kousuke Tashiro, Toru Tobe, Keisuke Nakayama, Satoru Kuhara, E. Oswald, Haruo Watanabe, Tetsuya Hayashi . Extensive genomic diversity and selective conservation of virulence-determinants in enterohaemorrhagic Escherichia coli strains of O157 and non-O157 serotypes. . Genome Biology8 ( 7 ) R138 2007年査読

A. Whale, RT. Hernandes, Tadasuke Ooka, G. Krause, S. Schuller, J. Garmendia, L. Crowther, MA. Vieira, Yoshitoshi Ogura, AD. Phillips, L. Beutin, TA. Gomes, Tetsuya Hayashi, G. Frankel . TccP2-mediated subversion of actin dynamics by EPEC 2 - a distinct evolutionary lineage of enteropathogenic Escherichia coli. . Microbiology153 1743 - 1755 2007年査読

Yoshitoshi Ogura, Tadasuke Ooka, A. Whale, J. Garmendia, L. Beutin, S. Tennant, G. Krause, S. Morabito, I. Chinen, Toru Tobe, Hiroyuki Abe, R. Tozzoli, A. Caprioli, M. Rivas, RR. Browne, Tetsuya Hayashi, G. Frankel . TccP2 of O157:H7 and non-O157 Enterohemorrhagic Escherichia coli (EHEC): challenging the dogma of EHEC-induced actin polymerization. . Infection and Immunity75 604 - 612 2007年査読

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