Faculty Profiles - TAKEDA Aya

Papers - TAKEDA Aya

Division display 1 - 20 of about 70 ／ All the affair displays >>

Mari Kirishima, Ikuma Kato, Masanori Hisaoka, Yukio Nakatani, Aya Harada Takeda, Keiko Mizuno, Akihide Tanimoto . Solid endobronchial tumor with EWSR1-FLI1 fusion gene - A diagnostically challenging case of the Ewing sarcoma. . Pathology international 2021.6Reviewed

Jingushi K.Masaya Aoki, Kazuhiro Ueda,Takahiro Kogaki, Masaya Tanimoto, Yuya Monoe, Masayuki Ando, Takuya Matsumoto, Kentaro Minami,Yuko Ueda, Kaori Kitae, Hiroaki Hase, Toshiyuki Nagata, Aya Harada-Takeda, Masatatsu Yamamoto,Kohichi Kawahara, Kazuhiro Tabata, Tatsuhiko Furukawa, Masami Sato, Kazutake Tsujikawa . ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer . Scientific Reports11 ( 1 ) 8677 2021.4Reviewed

Takahiro Kogaki, Ikumi Ohshio, Hasumi Ura, Souta Iyama, Kaori Kitae, Toshiya Morie, Shintarou Fujii, Shohei Sato, Toshiyuki Nagata, Aya Harada Takeda, Masaya Aoki, Kazuhiro Ueda, Kentaro Minami, Masatatsu Yamamoto, Kohichi Kawahara, Tatsuhiko Furukawa, Masami Sato, Yuko Ueda, Kentaro Jingushi, Zenzaburo Tozuka, Daisuke Saigusa, Hiroaki Hase, Kazutake Tsujikawa . Development of a highly sensitive method for the quantitative analysis of modified nucleosides using UHPLC-UniSpray-MS/MS. . Journal of pharmaceutical and biomedical analysis197 113943 - 113943 2021.4Reviewed

There are more than 150 types of naturally occurring modified nucleosides, which are believed to be involved in various biological processes. Recently, an ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) technique has been developed to measure low levels of modified nucleosides. A comprehensive analysis of modified nucleosides will lead to a better understanding of intracellular ribonucleic acid modification, but this analysis requires high-sensitivity measurements. In this perspective, we established a highly sensitive and quantitative method using the newly developed ion source, UniSpray. A mass spectrometer was used with a UniSpray source in positive ion mode. Our UHPLC-UniSpray-MS/MS methodology separated and detected the four major nucleosides, 42 modified nucleosides, and dG15N5 (internal standard) in 15 min. The UniSpray method provided good correlation coefficients (>0.99) for all analyzed nucleosides, and a wide range of linearity for 35 of the 46 nucleosides. Additionally, the accuracy and precision values satisfied the criteria of <15% for higher concentrations and <20% for the lowest concentrations of all nucleosides. We also investigated whether this method could measure nucleosides in biological samples using mouse tissues and non-small cell lung cancer clinical specimens. We were able to detect 43 and 31 different modified nucleosides from mouse and clinical tissues, respectively. We also found significant differences in the levels of N6-methyl-N6-threonylcarbamoyladenosine (m6t6A), 1-methylinosine (m1I), 2'-O-methylcytidine (Cm), 5-carbamoylmethyluridine (ncm5U), 5-methoxycarbonylmethyl-2-thiouridine (mcm5S2U), and 5-methoxycarbonylmethyl-2'-O-methyluridine (mcm5Um) between cancerous and noncancerous tissues. In conclusion, we developed a highly sensitive methodology using UHPLC-UniSpray-MS/MS to simultaneously detect and quantify modified nucleosides, which can be used for analysis of biological samples.

DOI： 10.1016/j.jpba.2021.113943

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Hiroaki Hase, Masaya Aoki, Kentaro Matsumoto, Shuichi Nakai, Toshiyuki Nagata, Aya Takeda, Kazuhiro Ueda, Kentaro Minami, Kaori Kitae, Kentaro Jingushi, Yuko Ueda, Masatatsu Yamamoto, Tatsuhiko Furukawa, Masami Sato, Kazutake Tsujikawa . Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer . Oncol Rep45 ( 1 ) 309 - 316 2020.11

Targeted Therapy Followed by Cytotoxic Chemotherapy in Preoperative Patients With Locally Advanced Lung Adenocarcinoma . 40 ( 5 ) 2911 - 2916 2020.5Reviewed

13. 武田　亜矢, 上田和弘,梅原正,前田光喜,青木雅也,永田俊行,横枕直哉,狩集弘太,佐藤雅美 . 蛍光ガイド手術の現状と展望７．呼吸器外科領域における研究と展望 . 日本外科学会雑誌121 ( 1 ) 48 - 53 2020.1

Takayuki Hirono, Kentaro Jingushi, Toshiyuki Nagata, Masami Sato, Kentaro Minami, Masaya Aoki, Aya Harada Takeda, Tadashi Umehara, Hiroshi Egawa, Yoshino Nakatsuji, Kaori Kitae, Yuko Ueda, Hiroaki Hase, Masatatsu Yamamoto, Yoshinari Shinsato, Kohichi Kawahara, Tatsuhiko Furukawa, Kazutake Tsujikawa . MicroRNA-130b functions as an oncomiRNA in non-small cell lung cancer by targeting tissue inhibitor of metalloproteinase-2 . Scientific Reports9 ( 1 ) 6956 - 6956 2019.12Reviewed

Non-small cell lung cancer (NSCLC) is the most frequent cause of cancer-related death worldwide. Although many molecular-targeted drugs for NSCLC have been developed in recent years, the 5-year survival rate of patients with NSCLC remains low. Therefore, an improved understanding of the molecular mechanisms underlying the biology of NSCLC is essential for developing novel therapeutic strategies for the treatment of NSCLC. In this study, we examined the role of miR-130b in NSCLC. Our results showed that high expression of miR-130b in clinical specimens was significantly associated with poor overall survival in patients with NSCLC. Moreover, miR-130b expression was significantly increased in NSCLC clinical specimens from patients with vascular and lymphatic invasion. Consistent with this, overexpression of miR-130b promoted invasion and matrix metalloproteinase-2 (MMP-2) activity in A549 cells. Argonaute2 immunoprecipitation and gene array analysis identified tissue inhibitor of metalloproteinase-2 (TIMP-2) as a target of miR-130b. Invasion activity promoted by miR-130b was attenuated by TIMP-2 overexpression in A549 cells. Furthermore, TIMP-2 concentrations in serum were inversely correlated with relative miR-130b expression in tumor tissues from the same patients with NSCLC. Overall, miR-130b was found to act as an oncomiR, promoting metastasis by downregulating TIMP-2 and invasion activities in NSCLC cells.

DOI： 10.1038/s41598-019-43355-8

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Computed tomographu-guided thoracoscopic debridement fou multiple loculated organizing empyema:a case report. Surgical Case Reports . 174 ( 5 ) 1 - 6 2019.11

Thoracoscopic en bloc resection of left upper lobe lung cancer . 2019.11

Successful treatment　of bronchial obstruction after lobectomy in a patient with scoliosis . 1 - 9 2019.9

Successful treatment　of bronchial obstruction after lobectomy in a patient with scoliosis . 2019.6

Masaya Aoki, Tadashi Umehara,Go Kamimura,Nobuhiro Imamura,Shoichiro Morizono,Yuto Nonaka,Takuya Tokunaga,Aya Harada Takeda,Koki Maeda,Yui Watanabe,Toshiyuki Nagata,Tsunayuki Otsuka,Naoya Yokomakura,Kota Kariatsumari,Masakazu Yanagi and Masami Sato . Expression of Bone Morphogenetic Protein-7 Significantly Correlates With Non-small Cell Lung Cancer Progression and Prognosis:A Retrospective Cohort Study . Clinical Medicine Insights:Oncology13 1 - 6 2019.4

Takayuki Hirono, Kentaro Jingushi,Kaori Kitae,Toshiyuki Nagata,Masami Sato,Kentaro Minami,Masaya Aoki,Aya Harada Takeda,Tadashi Umehara,Hiroshi Egawa,Yoshino Nakatsuji,Yuko Ueda,Tatsuhiko Furukawa and Kazutake Tsujikawa . MiR-301a/b function as oncomiRs in non-small-cell lung cancer . Integrative Molecular Medicine6 ( 5 ) 1 - 6 2018.12Reviewed

Maeda Koki, Kazuhiro Ueda,Aya Takeda,Naoya Yokomakura,Mari Kirishima,Masaya Aoki,Yuto Nonaka,Syoichiro Morizono,Nobuhiro Imamura,Takuya Tokunaga,Tadashi Umehara,Go Kamimura,Tsunayuki Otsuka,Kota Kariatsumari,Masakazu Yanagi and Masami Sato . Bronchial　atresia in an accessory lobe caused tension pneumothorax . SURGICAL CASE REPORTS 2018.12

Aya Harada Takeda, Toshiyuki Nagata, Yuto Nonaka, Nobuhiro Imamura, Shoichiro Morizono, Masami Sato . Crucial role of angiography in the surgical planning of a pulmonary artery aneurysm . Asian Cardiovascular and Thoracic Annals26 ( 9 ) 707 - 709 2018.11Reviewed

A 46-year-old woman was found to have an aneurysm of the superior segmental pulmonary artery in the right lower lung lobe on computed tomography images. Moreover, angiography revealed dilated bronchial arteries flowing into the aneurysm with neovascularization, and the contrast medium was partially pooled in the basal segment of the same lobe. The patient’s hemoptysis could not be controlled by an interventional radiology procedure. Therefore, lobectomy was carried out instead of aneurysmectomy. There has been no recurrence for 4 years after surgery. We considered that that angiographic information allowed for the most appropriate operation in this case.

DOI： 10.1177/0218492318805346

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Aya Harada Takeda, Yui Watanabe,Toshiyuki Nagata,Masaya Aoki,Tadashi Umehara,Soichi Suzuki,Go Kamimura,Kazuhiro wakida,Tsunayuki Otsuka,Naoya Yokomakura,Kota Kariatsumari,Koichi Sakasegawa,Yoshihiro Nakamura,Masami Sato . Detection of alternative subpleural lymph flow pathways using indocyanine green fluorescence . Surgery Today48 ( 6 ) 640 - 648 2018.1

Yui Watanabe, Tadashi Umehara, Aya Harada, Masaya Aoki, Takuya Tokunaga, Soichi Suzuki, Go Kamimura, Kazuhiro Wakida, Toshiyuki Nagata, Tsunayuki Otsuka, Naoya Yokomakura, Kota Kariatsumari, Yoshihiro Nakamura, Yuko Watanabe, Masami Sato . Successful closure of a tracheocutaneous fistula after tracheostomy using two skin flaps: a case report. . Surgical case reports1 ( 1 ) 43 - 43 2015.12Reviewed

A tracheocutaneous fistula may develop when a tracheostomy orifice epithelializes during a prolonged course of healing or undernutrition. Various techniques for closing such fistulae have been reported. However, a standard procedure has not yet been established. We, herein, present a case involving a 35-year-old woman who developed a tracheocutaneous fistula after tracheostomy. We closed the fistula using two skin flaps to cover the tracheal lumen and skin defect, respectively. The advantage of this technique is that it allows the tracheal lumen to be covered by inversed skin epithelium and ensures that the suture line of the skin does not match up with that of the subcutaneous tissue.

DOI： 10.1186/s40792-015-0045-1

PubMed

Tadashi Umehara, Masaya Aoki, Aya Harada, Yui Watanabe, Masami Sato . A Case of Nontuberculous Mycobacteria Highly Suspected as Lung Cancer Invading the Aortic Arch. . Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer10 ( 7 ) 1118 - 9 2015.7Reviewed

Yui Watanabe, Aya Harada, Masaya Aoki, Go Kamimura, Kazuhiro Wakida, Toshiyuki Nagata, Naoya Yokomakura, Kota Kariatsumari, Yoshihiro Nakamura, Masami Sato . Pulmonary Metastasectomy 31 Years After Surgery for Renal Cell Carcinoma. . The Annals of thoracic surgery99 ( 6 ) 2195 - 7 2015.6Reviewed

An 82-year-old man underwent a left upper lobectomy for a solitary tumor on suspicion of lung cancer. Histopathologic findings of the resected specimen showed clear cell renal cell carcinoma, which was diagnosed as a metastasis from kidney cancer concealed for 31 years after nephrectomy. The Ki-67 labeling index of the metastatic tumor was high (36.1%). A few cases of recurrent renal cell carcinoma after a long interval from initial diagnosis have been seen. However, pulmonary metastasectomy more than 30 years after radical nephrectomy for renal cell carcinoma has not been reported. This remarkable case provides new and valuable clinical insights into metastatic renal cell carcinoma.

DOI： 10.1016/j.athoracsur.2014.07.077

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Yui Watanabe, Masami Sato, Yoshihiro Nakamura, Yasushi Hoshikawa, Aya Harada, Toshiyuki Nagata, Goichi Yotsumoto, Yutaka Imoto, Yoshinori Okada, Takashi Kondo . Right lower lobe autotransplantation for locally advanced central lung cancer. . The Annals of thoracic surgery99 ( 1 ) 323 - 6 2015.1Reviewed

A 44-year-old man with locally advanced central lung cancer was treated by right lower lobe lung autotransplantation after pneumonectomy using an extracellular phosphate-buffered solution for cold lung preservation. The advantage of the ex vivo operation made it possible to perform safe and definitive cancer resection without massive bleeding. Cold lung preservation brought some advantages, such as reducing the risk of ischemia-reperfusion injury compared with warm ischemia and allowing enough time to achieve microscopically negative margins. The patient returned to normal life with minimum loss of pulmonary reserve and no recurrence of lung cancer for 6 months.

DOI： 10.1016/j.athoracsur.2014.02.065

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Papers - TAKEDA Aya