Faculty Profiles - HASHIMOTO Shinichi

Papers - HASHIMOTO Shinichi

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Iwashita Yuji, Hashimoto Shinichi, Hinokuchi Makoto, Fujita Toshihiro, Iwaya Hiromichi, Tanoue Shiroh, Taguchi Hiroki, Sueyoshi Kazunobu . A case of recurrence of ampullary adenoma in the pancreatic duct that developed into invasive carcinoma after endoscopic and transduodenal resection . Tando33 ( 4 ) 752 - 761 2019

Publisher：Japan Biliary Association

A 67-year-old man underwent endoscopic papillectomy for ampullary adenoma. The histological findings revealed a tubular adenoma. Endoscopic re-resection and transduodenal resection were performed because the local recurrence of adenoma. Three years later, the patient developed acute pancreatitis, and recurrence in the pancreatic duct was suspected. EUS revealed a low echoic mass in the pancreatic duct, and the pathological findings revealed an adenoma of biopsies from the orifice and pancreatic duct. We diagnosed the recurrence of ampullary adenoma and intraductal extension, and the patient underwent subtotal stomach-preserving pancreaticoduodenectomy. The pathological findings of the resected specimen revealed growth of adenoma in the main pancreatic duct and adenocarcinoma with invasion into the pancreatic parenchyma and duodenal wall. For cases suspected of repeated recurrence after local resection for ampullary adenoma, early pancreaticoduodenectomy should be considered.

DOI： 10.11210/tando.33.752

Fujita T. . Factors associated with the technical success of bilateral endoscopic metallic stenting with partial stent-in-stent placement in patients with malignant hilar biliary obstruction . Gastroenterology Research and Practice2019 5928040 2019

Komaki Yuga, Tanoue Shiroh, Hashimoto Shinichi, Ido Akio, Kanmura Shuji, Tanaka Akihito, Nakashima Mari, Komaki Fukiko, Iwaya Hiromichi, Arima Shiho, Sasaki Fumisato, Nasu Yuichiro . Cola Dissolution Therapy via Ileus Tube Was Effective for Ileus Secondary to Small Bowel Obstruction Induced by an Enterolith . Internal Medicine58 ( 17 ) 2473 - 2478 2019

Publisher：一般社団法人日本内科学会

An 87-year-old bedridden woman developed intestinal obstruction caused by an enterolith or bezoar. Since the patient refused surgery, we administered 1,000 mL/day of cola via an ileus tube to dissolve the stone. Occlusion of the small intestine disappeared on day 6. The excreted stones contained calcium phosphate, which is typical of enteroliths. We later confirmed that the retrieved stones could be dissolved in cola (Coca-Cola®, pH 1.9) as well as 0.10 and 0.010 mol/L hydrochloric acid (pH 1.0 and 2.0, respectively) and food-grade vinegar (pH 2.6). These findings suggest that the enteroliths were dissolved by an acid-base reaction.

DOI： 10.2169/internalmedicine.2745-19

Scopus

PubMed

Ito T. . Analysis of Prognostic Factors in Pancreatic Metastases: A Multicenter Retrospective Analysis . Pancreas47 ( 8 ) 1033 - 1039 2018.9

Hamamoto Hitomi, Hashimoto Shinichi, Taguchi Hiroki, Kojima Issei, Kasai Ai, Tsuneyoshi Kengo, Kuwazuru Kosuke, Arima Shiho, Kanmura Shuji, Ido Akio . 十二指腸壁の陥凹により閉塞性黄疸を発症した好酸球性胃腸炎(Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall) . Internal Medicine57 ( 13 ) 1841 - 1847 2018.7十二指腸壁の陥凹により閉塞性黄疸を発症した好酸球性胃腸炎(Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall)

Publisher：(一社)日本内科学会

症例は63歳女性で、高熱と心窩部痛が3ヵ月間続いており、上部消化管内視鏡検査で胃十二指腸の浮腫性肥厚が明らかになった。入院時の臨床検査で好酸球増加症と肝胆道系酵素値の上昇などが認められた。十二指腸の超音波内視鏡検査では十二指腸粘膜および筋肉壁が極度に肥厚しており、カプセル内視鏡では空腸の肥厚・浮腫がみられた。画像所見および病理学的所見から混合型の好酸球性胃腸炎と診断した。入院後に黄疸が出現し、腹部CTおよびMRIで総胆管内への十二指腸の陥凹が認められ、この陥凹による胆管閉塞が胆管炎や肝膿瘍の原因であると推測した。十二指腸壁の陥凹は保存療法後に改善したが、十二指腸内腔の狭窄により胆管ドレナージは不可能であった。ステロイドおよび抗アレルギー薬の投与により好酸球性胃腸炎は改善し、再発はみられなかった。

樺山雅之, 佐々木文郷, 前田英仁, 有馬志穂, 田ノ上史郎, 那須雄一郎, 橋元慎一, 上村修司, 門野潤, 井戸章雄 . 審査腹腔鏡が診断に有用であった胃癌術後再発による二次性アカラシアの1例 . 日本消化器病学会雑誌115 ( 4 ) 394 - 400 2018.4審査腹腔鏡が診断に有用であった胃癌術後再発による二次性アカラシアの1例

Publisher：(一財)日本消化器病学会

65歳男性。進行胃癌術後3年目に、嘔吐、体重減少が出現した。各種検査で食道アカラシア様の所見を認めた。(1)壮年層の発症、(2)短い有症状期間、(3)著明な体重減少を三徴とするTucker's criteriaを満たし、二次性アカラシアを疑った。原因として胃癌術後再発を疑い、審査腹腔鏡にて確定診断に至った。二次性アカラシアの診断には、Tucker's criteriaが有用であると考えられた。(著者抄録)

KABAYAMA Masayuki, IDO Akio, SASAKI Fumisato, MAEDA Hidehito, ARIMA Shiho, TANOUE Shiroh, NASU Yuichiro, HASHIMOTO Shinichi, KANMURA Shuji, KADONO Jun . A case of postoperative recurrent gastric cancer resembling esophageal achalasia diagnosed by staging laparoscopy . Nippon Shokakibyo Gakkai Zasshi115 ( 4 ) 394 - 400 2018

Publisher：The Japanese Society of Gastroenterology

A 65-year-old man underwent subtotal gastrectomy for advanced gastric cancer. The histological type of the cancer was signet-ring cell carcinoma, and the clinical stage was stage IB (T2N0M0). Three years after surgery, the patient had the following symptoms:dysphagia, odynophagia, and weight loss. Esophageal endoscopy and esophagography revealed a circular stenosis covered with the normal mucosa between the middle esophagus and the esophagogastric junction. Histologically, the samples obtained by staging laparoscopy revealed signet-ring cell carcinoma. Tucker's criteria are an important tool for differentiating secondary achalasia from primary achalasia with clinical value. Therefore, we suggest that staging laparoscopy is useful for the histological diagnosis of recurrent gastric cancer.

DOI： 10.11405/nisshoshi.115.394

Scopus

PubMed

Hamamoto Hitomi, Ido Akio, Hashimoto Shinichi, Taguchi Hiroki, Kojima Issei, Kasai Ai, Tsuneyoshi Kengo, Kuwazuru Kosuke, Arima Shiho, Kanmura Shuji . Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall . Internal Medicine57 ( 13 ) 1841 - 1847 2018

Publisher：一般社団法人日本内科学会

A 63-year-old woman was admitted with epigastric pain, eosinophilia, and elevated hepatobiliary enzyme levels. An upper gastrointestinal endoscopic examination showed that the mucosa of the gastroduodenal wall was edematous. Eosinophilic gastroenteritis (EGE) was diagnosed based on eosinophilic infiltration of the gastroduodenal mucosa. Computed tomography showed invagination of the duodenal wall into the common bile duct. The invagination of the duodenal wall improved after conservative therapy, while bile duct drainage was impossible due to the narrowing of the duodenal lumen. EGE was successfully treated without recurrence with steroids and antiallergic therapy. We herein report a rare case of EGE with obstructive jaundice.

DOI： 10.2169/internalmedicine.9312-17

Scopus

PubMed

Taguchi H. . Helicobacter pylori eradication improves the quality of life regardless of the treatment outcome . Medicine (United States)96 ( 52 ) e9507 2017.12

Hashimoto S. . Diagnostic efficacy of liquid-based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound-guided fine-needle aspiration: Propensity score-matched analysis . Digestive Endoscopy29 ( 5 ) 608 - 616 2017.7

Hashimoto Shinichi, Taguchi Hiroki, Higashi Michiyo, Hatanaka Kazuhito, Fujita Toshihiro, Iwaya Hiromichi, Nakazawa Junichi, Arima Shiho, Iwashita Yuji, Sasaki Fumisato, Nasu Yuichiro, Kanmura Shuji, Ido Akio . 超音波内視鏡下穿刺吸引法で採取した膵腫瘤性病変検体に対するliquid-based cytologyの診断的有効性　傾向スコアマッチング解析(Diagnostic efficacy of liquid-based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound-guided fine-needle aspiration: Propensity score-matched analysis) . Digestive Endoscopy29 ( 5 ) 608 - 616 2017.7超音波内視鏡下穿刺吸引法で採取した膵腫瘤性病変検体に対するliquid-based cytologyの診断的有効性　傾向スコアマッチング解析(Diagnostic efficacy of liquid-based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound-guided fine-needle aspiration: Propensity score-matched analysis)

Publisher：John Wiley & Sons Australia, Ltd

超音波内視鏡下穿刺吸引法(EUS-FNA)で採取した膵腫瘤性病変検体に対するliquid-based cytology(LBC)法とconventional Papanicolaou smear(CPS)法の診断的有効性を比較するため後向き研究を実施した。対象は2009年1月〜2014年8月に当院で腫瘤性病変に対して初回EUS-FNAを施行した患者126例で、このうち63例は2012年5月迄にCPSによる細胞診を施行し、その後63例にLBCによる細胞診を施行した。悪性腫瘍の全発生率は86%であった。LBCはCPSと比較して感度および正診率が高かった。LBCは膵頭部病変の診断において感度が高かった。膵管腺癌(PDAC)の感度もLBCが高かった。多変量解析により、PDAC以外の悪性腫瘍と20mm以下の病変は全参加者においてLBCによる誤診の危険因子であることが明らかになった。以上から、膵腫瘤性病変に対するEUS-FNAにおいてLBCは悪性腫瘍の診断に有用であるが、PDAC以外の悪性腫瘍と小型腫瘍の場合はEUS-FNAとLBCの診断は困難であることが示された。

Ono Y. . The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn's disease . BMC Gastroenterology17 ( 1 ) 40 2017.3

Maeda T, Sakiyama T, Kanmura S, Hashimoto S, Ibusuki K, Tanoue S, Komaki Y, Arima S, Nasu Y, Sasaki F, Taguchi H, Numata M, Uto H, Tsubouchi H, Ido A . Low concentrations of human neutrophil peptide ameliorate experimental murine colitis. . Int J Mol Med 2016.12Low concentrations of human neutrophil peptide ameliorate experimental murine colitis.Reviewed

Kozono M, Uto H, Ibusuki R, Arima S, Oda K, Taguchi H, Sasaki F, Nasu Y, Hashimoto S, Setoyama H, Kanmura S, Numata M, Tsubouchi H, Ido A. . Antihypertensive therapy improves insulin resistance and serum levels of interleukin-6 and -10 in spontaneously hypertensive rats with steatohepatitis. . Mol Med Rep 2016.12Antihypertensive therapy improves insulin resistance and serum levels of interleukin-6 and -10 in spontaneously hypertensive rats with steatohepatitis.Reviewed

Hashimoto S, Ito K, Koshida S, Kanno Y, Ogawa T, Masu K, Iwashita Y, Horaguchi J, Kobayashi G, Noda Y . Risk Factors for Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis and Stent Dysfunction after Preoperative Biliary Drainage in Patients with Malignant Biliary Stricture. . Intern Med 2016.9Risk Factors for Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis and Stent Dysfunction after Preoperative Biliary Drainage in Patients with Malignant Biliary Stricture.Reviewed

Yokoyama S, Higashi M, Kitamoto S, Oeldorf M, Knippschild U, Kornmann M, Maemura K, Kurahara H, Wiest E, Hamada T, Kitazono I, Goto Y, Tasaki T, Hiraki T, Hatanaka K, Mataki Y, Taguchi H, Hashimoto S, Batra SK, Tanimoto A, Yonezawa S, Hollingsworth MA . Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas . Oncotarget 2016.6Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomasReviewed

Hashimoto S, Sendo K, Ido A . Endoscopic double stenting for afferent and efferent loop stenosis in a patient with recurrent gastric carcinoma after Billroth II reconstruction. . Dig Endosc 2016.5Endoscopic double stenting for afferent and efferent loop stenosis in a patient with recurrent gastric carcinoma after Billroth II reconstruction.Reviewed

Kanmura S, Hamamoto H, Morinaga Y, Oda K, Fujita T, Arima S, Nasu Y, Sasaki F, Hashimoto S, Taguchi H, Setoyama H, Ido A. . Fecal Human Neutrophil Peptide Levels Correlate with Intestinal Inflammation in Ulcerative Colitis . Digestion 2016.5Fecal Human Neutrophil Peptide Levels Correlate with Intestinal Inflammation in Ulcerative ColitisReviewed

前田英仁, 橋元慎一, 中澤潤一, 有馬志穂, 田口宏樹, 那須雄一郎, 佐々木文郷, 上村修司, 瀬戸山仁, 門野潤, 東美智代, 井戸章雄 . 胃の瘻孔から主膵管内をNBI（narrow band imaging）拡大観察し得た混合型IPMC（Intraductal Papillary-Mucinous Carcinoma）の一例 . 膵臓 2016.1胃の瘻孔から主膵管内をNBI（narrow band imaging）拡大観察し得た混合型IPMC（Intraductal Papillary-Mucinous Carcinoma）の一例Reviewed

Sasaki F, Kumagai K, Uto H, Takami Y, Kure T, Tabu K, Nasu Y, Hashimoto S, Kanmura S, Numata M, Moriuchi A, Sakiyama T, Tsubouchi H, Ido A. . Expression of glycoprotein nonmetastatic melanoma protein B in macrophages infiltrating injured mucosa is associated with the severity of experimental colitis in mice. . Mol Med Rep 2015.11Expression of glycoprotein nonmetastatic melanoma protein B in macrophages infiltrating injured mucosa is associated with the severity of experimental colitis in mice.Reviewed

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Papers - HASHIMOTO Shinichi