Faculty Profiles - HASHIMOTO Shinichi

Papers - HASHIMOTO Shinichi

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Toyodome Koshiro, Taguchi Hiroki, Hinokuchi Makoto, Fujita Toshihiro, Iwaya Hiromichi, Iwashita Yuji, Tanoue Shiroh, Hashimoto Shinichi, Nagata Yuki, Hatanaka Shingo, Higashi Michiyo . A case of communicating accessory bile duct with double cystic ducts and a fibrous polyp in the bile duct . Tando35 ( 2 ) 188 - 196 2021.5

Language：Japanese Publisher：Japan Biliary Association

A 66-year-old woman was referred to our department for the examination of a pancreatic cyst. Endoscopic ultrasonography showed a tumor in the bile duct and another duct communicating with the bile duct. Cholangiography revealed the bile ducts forming a circuit, double cystic ducts, and a defect suspected of the bile duct tumor. Communicating accessory bile ducts (CABDs) and a fibrous polyp were diagnosed based on the imaging and pathological findings. After subtotal stomach-preserving pancreaticoduodenectomy, CABDs were histologically confirmed. We report a rare case of CABD with double cystic ducts and a bile duct fibrous polyp.

DOI： 10.11210/tando.35.188

CiNii Research

豊留孝史郎, 田口宏樹, 樋之口真, 藤田俊浩, 岩屋博道, 岩下祐司, 田ノ上史郎, 橋元慎一, 永田祐貴, 畠中真吾, 東美智代 . 重複胆嚢管様の胆道走行および胆管線維性ポリープを伴った、副交通胆管枝(communicating accessory bile duct)の1例 . 胆道35 ( 2 ) 188 - 196 2021.5

Language：Japanese Publisher：(一社)日本胆道学会

症例は66歳女性.腹部超音波検査で膵頭部嚢胞が疑われ当科を受診した.MRCP,EUSで総胆管および近傍に胆管と思われる管腔構造を認めた.造影EUSでは,胆管内に多血性の低エコー腫瘤を認め,胆管腫瘍の合併も疑われた.胆管造影では,胆管内は隔壁様の構造で隔たれ環状構造を形成しており,副交通胆管枝(communicating accessory bile duct:CABD)と診断した.また,胆嚢管は2本に分岐し,それぞれの胆管に合流し,重複胆嚢管類似の胆道走行を認めた.胆管内には輪郭不整な透亮像を認め,腫瘍生検結果は線維性ポリープであった.亜全胃温存膵頭十二指腸切除術が施行され,術後病理標本では,膵上縁より上流のレベルで重複した胆管上皮を認め,CABDに矛盾しない所見であった.CABDと重複胆嚢管類似の複雑な胆道構造および,胆管線維性ポリープを合併した症例を報告する.(著者抄録)

Kanmura S. . Increased Gene Copy Number of DEFA1A3 Is Associated With the Severity of Ulcerative Colitis . Clinical and translational gastroenterology12 ( 4 ) e00331 2021.4

Language：Japanese Publisher：Clinical and translational gastroenterology

INTRODUCTION:DEFA1A3 encodes human neutrophil peptides (HNPs) 1-3 and has multiple copy number variations (CNVs). HNPs are associated with innate immunity. Ulcerative colitis (UC), a chronic inflammatory gastrointestinal disorder, is a life-threatening condition, and predictive markers of UC severity are needed. This study investigated the relationship between DEFA1A3 CNV and UC severity.METHODS:This study enrolled 165 patients with UC. The relationship between DEFA1A3 CNV and disease severity was analyzed based on Mayo score, patient characteristics, and treatment methods. In addition, serum and stimulated neutrophil-derived HNP concentrations were also measured in patients with high and low DEFA1A3 CNV.RESULTS:DEFA1A3 CNV was significantly correlated with Mayo score and white blood cell count (R = 0.46, P < 0.0001; R = 0.29, P = 0.003, respectively), and only high copy numbers of DEFA1A3 were independent factors for severe UC (P < 0.001, odds ratio: 1.88, 95% confidence interval, 1.34-2.61). The number of severe UC patients with high DEFA1A3 CNV was significantly greater than those with low CNV. We confirmed the associations between DEFA1A3 and UC severity using a validation cohort. In addition, the HNP concentration in high-copy number patients was significantly higher after neutrophil stimulation than that in low-copy number patients.DISCUSSION:This study demonstrated that there is a correlation between DEFA1A3 copy number and severity in patients with UC. In addition, neutrophils from UC patients with higher DEFA1A3 CNV had high reactivity of secretion of HNPs after stimulation. DEFA1A3 CNV may be a novel severity marker and a potential therapeutic target for UC.

DOI： 10.14309/ctg.0000000000000331

Scopus

PubMed

Iwaya H. . Prognostic significance of extracellular volume fraction with equilibrium contrast-enhanced computed tomography for pancreatic neuroendocrine neoplasms . Pancreatology21 ( 4 ) 779 - 786 2021

Language：Japanese Publisher：Pancreatology

Background: /Objectives: Identifying reliable pretreatment imaging biomarkers for pancreatic neuroendocrine neoplasm (PanNEN) is a key imperative. Extracellular volume (ECV) fraction quantified with equilibrium contrast-enhanced CT can be easily integrated into routine examinations. This study aimed to determine whether ECV fraction with equilibrium contrast-enhanced computed tomography (CECT) could predict long-term outcomes in patients with PanNEN. Methods: This study was a retrospective observational study of 80 patients pathologically diagnosed with PanNEN at a single institution. ECV fraction of the primary lesion was calculated using region-of-interest measurement within PanNEN and the aorta on unenhanced and equilibrium CECT. The impact of clinical factors and tumor ECV fraction on progression-free survival (PFS) and overall survival (OS) was assessed with univariate and multivariate analyses using Cox proportional hazards models. The correlation between WHO classification and tumor ECV fraction was evaluated using Kendall rank correlation coefficients. Results: PFS and OS rates were estimated as 93.4% and 94.6%, 78.7% and 86.2%, 78.7% and 77.0%, and 78.7% and 66.6% at 1, 3, 5, and 10 years, respectively. Multivariate analysis revealed that Union for International Cancer Control (UICC) stage (hazard ratio [HR] = 3.95, P = 0.003), WHO classification (HR = 12.27, P = 0.003), and tumor ECV fraction (HR = 11.93, P = 0.039) were independent predictors of PFS. Patient age (HR = 1.11, P < 0.001), UICC stage (HR = 3.14, P = 0.001), and tumor ECV fraction (HR = 5.27, P = 0.024) were independent significant variables for predicting OS. Tumor ECV fraction had a weak inverse relationship with WHO classification (P = 0.045, τ = −0.178). Conclusions: ECV fraction determined by equilibrium CECT and UICC stage may predict survival in patients with PanNEN.

DOI： 10.1016/j.pan.2021.02.020

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PubMed

Sasaki F, Kanmura S, Oda K, Maeda H, Kabayama M, Iwaya H, Komaki Y, Arima S, Tanoue S, Hashimoto S, Fujita H, Ido A . Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma. . PloS one16 ( 5 ) e0251457 2021

Language：Japanese Publisher：PLoS ONE

Patients with inactive acetaldehyde dehydrogenase 2 (ALDH2) are at high risk for esophageal squamous cell carcinoma (ESCC) and hypopharyngeal squamous cell carcinoma (HPSCC). The acetaldehyde breath test (ABT) may demonstrate ALDH2 gene polymorphisms. We evaluated the usefulness of the ABT in patients with ESCC and HPSCC. The squamous cell carcinoma (SCC) group consisted of 100 patients who were treated with endoscopic submucosal dissection (ESD) for ESCC or HPSCC, and the control group (HC) consisted of 275 healthy subjects. The SCC group comprised the "single subgroup"(n = 63), in which a single lesion was initially treated with ESD, and the "multiple subgroup"(n = 31), in which multiple lesions were initially treated with ESD. First, we compared the groups' risk factors for carcinogenesis and measured the acetaldehyde-to-ethanol (A/E) ratio. Then we tested the groups' differences in the abovementioned carcinogenic risk factors. We found that the proportion of individuals in the SCC group with inactive ALDH2 (A/E ratio ≥ 23.3) was significantly higher than that in the HC group (p = 0.035), as was the A/E ratio (p < 0.001). Also, the proportion of individuals with inactive ALDH2 in the multiple subgroup was significantly higher than that in single subgroup (p = 0.015), as was the A/E ratio (p = 0.008). In conclusion, ABT may be a potential screening tool for detecting people at risk of ESCC and HPSCC. In addition, it could be a useful tool in detecting patients at risk of multiple or double carcinomas among patients with ESCC and HPSCC.

DOI： 10.1371/journal.pone.0251457

Scopus

PubMed

Nakazawa J. . Analysis of factors affecting progression-free survival of first-line chemotherapy in older patients with advanced gastrointestinal cancer . Journal of Geriatric Oncology12 ( 8 ) 1200 - 1207 2021

Language：Japanese Publisher：Journal of Geriatric Oncology

Objectives: Few studies have investigated factors influencing the efficacy of chemotherapy in older patients with cancer. This study aimed to evaluate the usefulness of G8, geriatric assessment (GA), and factors measured in general clinical practice for evaluating progression-free survival (PFS) of first-line palliative chemotherapy in older patients with advanced gastrointestinal cancer. Materials and methods: This was a prospective observational study of older patients (age ≥70 years) with advanced gastrointestinal cancer. The modified cut-off value of G8 was determined by referring to two or more abnormal GA conditions. The usefulness of baseline GA and G8 (conventional and modified cut-off value) was assessed according to the efficacy (PFS and disease control rate) of the administered first-line palliative chemotherapy. Results: Overall, 93 patients were evaluated between March 2017 and February 2019. A modified G8 cut-off value of ≤12 had a sensitivity and specificity of 68.9% and 46.9%, respectively. PFS was significantly prolonged in the patients with G8 > 12, serum albumin ≥3.5 g/dl, and in whom grade ≥3 adverse events occurred. There was no significant difference in the PFS between monotherapy and combination therapy. GA was not useful for predicting PFS prolongation or the occurrence of serious adverse events in first-line treatment. Conclusion: Among older patients with advanced gastrointestinal cancer who receive first-line chemotherapy, a modified G8 cut-off value of 12 points, occurrence of grade 3 or higher adverse events, albumin levels, rather than age or performance status were predictors of PFS prolongation.

DOI： 10.1016/j.jgo.2021.05.006

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PubMed

矢野弘樹, 橋元慎一, 田口宏樹, 田ノ上史郎, 岩屋博道, 有馬志穂, 佐々木文郷, 上村修司, 東美智代, 井戸章雄 . 膵体部癌との鑑別に難渋し、切除標本により診断し得た2型自己免疫性膵炎の1例 . 膵臓35 ( 5 ) 447 - 454 2020.10

Publisher：(一社)日本膵臓学会

症例は46歳女性.心窩部痛,嘔気を主訴に受診した.膵酵素の上昇を認め,急性膵炎の診断で保存的に加療された.画像所見で膵体尾部実質の不均一な造影効果と尾側膵管の拡張を認め,膵腫瘍が疑われた.EUS-FNAにおける組織診断で確定診断が得られなかったが,膵体部癌の可能性が否定できず,手術治療を行った.切除標本にて特徴的な組織所見を示し,2型自己免疫性膵炎の診断に至った.(著者抄録)

Nishikoba N. . HGF-MET Signaling Shifts M1 Macrophages Toward an M2-Like Phenotype Through PI3K-Mediated Induction of Arginase-1 Expression . Frontiers in Immunology11 2135 2020.9

Sasaki S, Hashimoto S, Yamamoto K, Sakaida I . Olmesartan-associated Enteropathy Mimics Endoscopic Findings of Celiac Disease. . Internal medicine (Tokyo, Japan)59 ( 14 ) 1777 - 1778 2020.7

笠井亜衣, 橋元慎一, 恒吉研吾, 樺山雅之, 岩屋博道, 有馬志穂, 田口宏樹, 上村修司, 東美智代, 井戸章雄 . 膵臓の腫瘤性病変に対するEUS-FNAで診断に至ったB細胞リンパ腫の3例 . 膵臓35 ( 2 ) 213 - 221 2020.4

Publisher：(一社)日本膵臓学会

膵原発の悪性リンパ腫は,節外性悪性リンパ腫の2%以下,膵悪性腫瘍の0.5%未満と稀である.画像所見のみでは鑑別が難しく,病理組織学的評価による正確な診断が重要である.今回,膵腫瘤に対し超音波内視鏡下穿刺吸引法(EUS-FNA)でB細胞リンパ腫と診断した3例を経験し,うち2例は化学放射線療法で改善した.EUS-FNAは,リンパ腫の病型診断および治療方針決定に有用と考えられた.(著者抄録)

Kurita A. . Comparison of a 22-gauge Franseen-tip needle with a 20-gauge forward-bevel needle for the diagnosis of type 1 autoimmune pancreatitis: a prospective, randomized, controlled, multicenter study (COMPAS study) . Gastrointestinal Endoscopy91 ( 2 ) 373 - 381.e2 2020.2

Kamikihara Y. . A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy . Oncology Letters19 ( 1 ) 247 - 254 2020

KASAI Ai, IDO Akio, HASHIMOTO Shinichi, TSUNEYOSHI Kengo, KABAYAMA Masayuki, IWAYA Hiromichi, ARIMA Shiho, TAGUCHI Hiroki, KANMURA Shuji, HIGASHI Michiyo . Three patients with B cell lymphoma diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of pancreatic lesions . Suizo35 ( 2 ) 213 - 221 2020

Publisher：Japan Pancreas Society

Three patients with pancreatic lymphoma were seen. Primary pancreatic lymphoma accounts for less than 2% of extranodal malignant lymphomas and less than 0.5% of malignant tumors of the pancreas. In patients with pancreatic lymphoma, an accurate diagnosis is crucial because the tumor is difficult to distinguish from other pancreatic tumors-especially pancreatic cancer-based on imaging findings alone, and because the treatment depends on the specific type of lymphoma. Two of these patients improved after chemoradiation therapy. EUS-FNA was useful for determining the type of lymphoma and determining the treatment strategy.

DOI： 10.2958/suizo.35.213

CiNii Research

YANO Hiroki, IDO Akio, HASHIMOTO Shinichi, TAGUCHI Hiroki, TANOUE Shiroh, IWAYA Hiromichi, ARIMA Shiho, SASAKI Fumisato, KANMURA Shuji, HIGASHI Michiyo . Type 2 autoimmune pancreatitis diagnosed after resection and difficult to differentiate from cancer of the pancreatic body . Suizo35 ( 5 ) 447 - 454 2020

Publisher：Japan Pancreas Society

The patient is a 46-year-old woman admitted with epigastric pain and nausea. She was found to have elevated pancreatic enzymes and treated for acute pancreatitis. Imaging findings showed uneven contrast enhancement of the pancreatic body to tail and enlargement of the caudal pancreatic duct. A pancreatic tumor was suspected. Although no definitive histologic diagnosis was obtained using endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA), the possibility of pancreatic body cancer could not be ruled out, and resection was performed. The resected specimen showed characteristic histologic findings, leading to a diagnosis of type 2 autoimmune pancreatitis.

DOI： 10.2958/suizo.35.447

CiNii Research

Kanmura S. . Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis . Gastroenterology Research and Practice2020 3108690 2020

Tanaka A. . Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti-inflammatory response . Molecular Medicine Reports21 ( 3 ) 1181 - 1191 2020

Yamao K. . Endoscopic placement of covered versus uncovered self-expandable metal stents for palliation of malignant gastric outlet obstruction . Gut70 ( 7 ) 1244 - 1252 2020

Language：Japanese Publisher：Gut

Objective Stenting is an established endoscopic therapy for malignant gastric outlet obstruction (mGOO). The choice of stent (covered vs uncovered) has been examined in prior randomised studies without clear results. Design In a multicentre randomised prospective study, we compared covered (CSEMS) with uncovered self-expandable metal stents (UCSEMS) in patients with mGOO; main outcomes were stent dysfunction and patient survival, with subgroup analyses of patients with extrinsic and intrinsic tumours. Results Overall survival was poor with no difference between groups (probability at 3 months 49.7% for covered vs 48.4% for uncovered stents; log-rank for overall survival p=0.26). Within that setting of short survival, the proportion of stent dysfunction was significantly higher for uncovered stents (35.2% vs 23.4%, p=0.01) with significantly shorter time to stent dysfunction. This was mainly relevant for patients with extrinsic tumours (stent dysfunction rates for uncovered stents 35.6% vs 17.5%, p<0.01). Subgrouping was also relevant with respect to tumour ingrowth (lower with covered stents for intrinsic tumours; 1.6% vs 27.7%, p<0.01) and stent migration (higher with covered stents for extrinsic tumours: 15.3% vs 2.5%, p<0.01). Conclusions Due to poor patient survival, minor differences between covered and uncovered stents may be less relevant even if statistically significant; however, subgroup analysis would suggest to use covered stents for intrinsic and uncovered stents for extrinsic malignancies.

DOI： 10.1136/gutjnl-2020-320775

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PubMed

Maeda H. . Covering Post-Endoscopic Submucosal Dissection Ulcers in Miniature Swine with Hexanoyl (Hx:C6) Group-Modified Alkaline-Treated Gelatin Porous Film (HAG) Induces Proper Healing by Decreasing Inflammation and Fibrosis . Digestion102 ( 3 ) 1 - 13 2020

Language：Japanese Publisher：Digestion

Background and Aims: Hexanoyl (Hx:C6) group-modified alkaline-treated gelatin porous film (HAG) is a newly developed degradable hydrogel characterized by strong adhesiveness and high affinity for vascular endothelial growth factor (VEGF). The aim of this study was to clarify the effect of HAG sheets on the healing process of post-endoscopic submucosal dissection (ESD) porcine gastric artificial ulcers. Methods: (1) To evaluate the adhesiveness of HAG sheets over time, we performed ESD to create 1 artificial ulcer and covered the lesion with 1 HAG sheet using 1 miniature swine. We observed 2 ulcers by endoscopic and microscopic examinations. (2) To examine the effect of HAG sheets on post-ESD ulcer healing, we performed ESD using 5 miniature swine. The artificial ulcers were covered with HAG sheets, or left uncovered after ESD (day 0), followed by macroscopic and microscopic examinations. On days 7 and 14, we observed 2 ulcers by endoscopic examinations. On day 14, the animals were sacrificed, and histological examination was performed on the 3 stomachs that could be extirpated. Results: (1) On day 7, adhesion of HAG sheets was observed. (2) Gastric ulcer area on day 7 was significantly larger in the covered ulcers than in the non-covered ulcers (p = 0.046). On day 14, although there was no significant difference in ulcer area irrespective of covering (p = 0.357), the covered ulcers tended to repair less fold convergence than non-covered ulcers. The covered ulcer sheets significantly decreased inflammatory cell infiltration (p = 0.011), but significantly increased the abundance of macrophages (p = 0.033), in submucosal layers. Also, the abundance of alpha-smooth muscle actin-positive cells in submucosal layers of the covered ulcers was significantly reduced (p = 0.044), leading to a decrease in collagen accumulation. In addition, fibrosis and atrophy of the muscularis propria were significantly lower for covered ulcers than for non-covered ulcers. Furthermore, microvessels and VEGF-positive cells were significantly more abundant in the submucosal layers of the covered ulcers (p < 0.001 and p = 0.024, respectively). Conclusions: HAG sheets induced post-ESD ulcer healing with less submucosal inflammation and muscularis propria injury and have the potential to decrease excess scarring.

DOI： 10.1159/000509056

Scopus

PubMed

Hiraishi N. . Extract of Lactobacillus plantarum strain 06CC2 induces JNK/p38 MAPK pathway-mediated apoptosis through endoplasmic reticulum stress in Caco2 colorectal cancer cells . Biochemistry and Biophysics Reports20 100691 2019.12

岩下祐司, 橋元慎一, 樋之口真, 藤田俊浩, 岩屋博道, 田ノ上史郎, 田口宏樹, 末吉和宣 . 内視鏡的・外科的乳頭部切除後に主膵管内再発・癌化をきたした十二指腸乳頭部腺腫の1例 . 胆道33 ( 4 ) 752 - 761 2019.10

Publisher：日本胆道学会

症例は67歳、男性。2011年11月に前医で十二指腸乳頭部腺腫に対して内視鏡的乳頭部切除術を施行された。病理結果は管状腺腫であった。2012年2月に局所再発をきたし内視鏡的に切除されたが、遺残があり外科的乳頭部切除術が施行された。2013年5月にも局所再発に対し内視鏡的焼灼術が施行された。以後は再発なく経過したが、2015年7月に急性膵炎を契機に主膵管内に再発が疑われ、当科紹介となった。EUSで膵頭部主膵管内に腫瘤を認め、ERP下の膵管口周囲・膵管内生検で腺腫を認めたことから、十二指腸乳頭部腺腫の局所再発・主膵管内進展と診断し、亜全胃温存膵頭十二指腸切除術を行った。病理組織では膵頭部主膵管内に腺腫腺管の増殖を認め、乳頭部近傍で十二指腸壁及び膵実質への浸潤を呈する浸潤癌に発展していた。乳頭部腺腫局所切除後に再発を繰り返す例では、早期の膵頭十二指腸切除術を考慮する必要があると考えられる。(著者抄録)

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Papers - HASHIMOTO Shinichi