Updated on 2026/05/30

写真a

 
UNO Seiichi
 
Organization
Research Field in Fisheries, Agriculture, Fisheries and Veterinary Medicine Area Faculty of Fisheries Education and Research Center for Marine Resources and Environment Professor
Title
Professor
Degree
Doctor (Fisheries) (1997.3 Tokyo University of Fisheries)

Research Interests

  • 微量分析

  • 環境汚染物質の体内動態

  • 農薬

  • 石油汚染

  • ニトロアレーン

  • 多環芳香族炭化水素

  • メタボロミクス

  • Oil Pollution

  • Environmental Chemistry

  • Marine Organisms

  • Marine Pollution

  • 底質影響評価

  • Polycyclic Aromatic Hydrocarbons (PAHs)

  • 化学物質の生物蓄積

  • metabolomics

  • Environmental Pollution

Research Areas

環境毒性学, 環境化学, Environmental impact assessment, Environmental impact assessment, Environmental load and risk assessment, Environmental dynamic analysis, Aquatic bioproduction science

Research History

  • 2018.10    Kagoshima University   Research Field in Fisheries, Agriculture, Fisheries and Veterinary Medicine Area Faculty of Fisheries Education and Research Center for Marine Resources and Environment   Professor

  • 2004.1    Kagoshima University

  • 2004.1 - 2018.9    Kagoshima University   Research Field in Fisheries, Agriculture, Fisheries and Veterinary Medicine Area Faculty of Fisheries Education and Research Center for Marine Resources and Environment   Associate Professor

Professional Memberships

  • 2015.10    日本環境化学会

  • 2015.10    日本環境毒性学会

  •    日本環境化学会

  •    日本環境毒性学会

Committee Memberships

  • 2022 - 2024    環境省   海洋プラスチックごみによる生物・生態系影響把握等業務 有害性評価分科会 委員   Government

  • 2022 - 2023    経済産業省   化学物質の分解性及び蓄積性に係る総合的評価の導入に関する調査 委員   Government

  • 2021 - 2022    環境省   海洋プラスチックごみによる生物・生態系リスク評価検討委員会-レビュー分科会 委員   Government

  • 2020 - 2021    経済産業省   化学物質の分解性及び蓄積性に係る総合的評価の導入に関する調査 委員   Government

  • 2019    経済産業省   化学物質審議会 審査部会（化審法審議会） 委員   Government

  • 2018    環境省   化審法評価支援等検討会 有害性評価（評価II等） 委員   Government

  • 2017    一般財団法人九州環境管理協会   技術諮問委員   Other

  • 2017 - 2024    熊本県   熊本県県南広域本部球磨地域振興局・清願寺地区防災ダム事業土砂検討委員会委員   Municipal

  • 2013.11 - 2024    経済産業省製造産業局   化学物質審査検討会（予審）専門委員   Government

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Papers

  • Imamura Kazuki, Nakayama Kei, Yamasaki Masatoshi, Kokushi Emiko, Fukugami Shusaku, Uno Seiichi .  Exploring toxicants derived from sediments using biological responses in fish embryos .  Japanese Journal of Environmental Toxicology29 ( 1 ) 1 - 13   2026.3

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    Language：Japanese   Publisher：The Japanese Society of Environmental Toxicology  

    <p>Sediments constitute the benthic environment, and play an important role in marine ecosystems. Various chemicals persist in sediments and can affect the benthic organisms. However, it has generally been difficult to identify specific toxicants that critically the effects in organisms. In the present study, we evaluated the toxicities of sediments collected from several sites in Japanese coastal areas, using fish embryos. As a result, some sediments induced embryo mortality and malformation in hatching larvae. We explored several approaches to facilitate the identification of causative chemicals based on biological responses in fish embryos. Hydrophobic extracts added into test water obtained from most sediments induced effects such as mortality and malformations in embryos. However, because hydrophilic extracts also affected embryos for a few sites, we could not distinguish the remarkable signatures based solely on the extract exposures. In addition, receptor activation by ligand-binding chemicals derived from these extracts―implicating xenobiotic metabolism, vitamin metabolism, and other pathways―was examined using the corresponding nuclear receptor target genes, and some genes changed at least partially with their effect-related factors. The approach of obtaining extracts followed by gene analysis, owing to its broad applicability, was suggested to be a potentially effective method for picking up candidate causative toxicants in sediments in the future.</p>

    DOI： 10.11403/jset.29.1

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  • Imamura K., Maehara A., Nakamura S., Uno S., Kokushi E. .  Oxygenated PAHs in Tokyo Bay sediments: distributional contrast with parent PAHs and their effect evaluations with fish embryos .  Environmental Monitoring and Assessment198 ( 3 )   2026.3

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    Language：Japanese   Publisher：Environmental Monitoring and Assessment  

    Oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) are a group of PAHs derivatives formed by chemical or microbial oxidation that can negatively affect benthic organisms. However, their distribution in coastal sediments remains poorly understood. In the present study, we examined the distribution and ecological risks of oxy-PAHs in sediments collected from 18 sites in Tokyo Bay, Japan. Concentrations of target oxy-PAHs ranged from 10.2 to 1299 ng/g dry weight, generally exceeding previously reported values. Strong correlations were found between oxy-PAHs and sediment carbon content and between oxy-PAHs and parent PAHs, possibly showing common sources or transformation pathways. Lethal and developmental effects were observed in Java medaka (Oryzias javanicus) embryos exposed to the artificial sediments spiked with two oxy-PAHs (7,12-benz(a)anthraquinone and 1,4-naphthoquinone) found at several locations in Tokyo Bay. Both risk quotient indices exceeding 1 were shown at more than 10 sites, and suggest that these 2 substances may pose potential threats to benthic organisms at a number of sites in Tokyo Bay.

    DOI： 10.1007/s10661-026-15109-3

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  • Matsuo J., Fukugami S., Nakayama K., Yamasaki M., Kokushi E., Uno S. .  Interspecific Differences in the Effects on Embryos Between Freshwater and Marine Fish Exposed to Water-Accommodated Fractions Derived From Very-Low Sulfur Fuel Oil .  Environmental Toxicology   2026

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    Language：Japanese   Publisher：Environmental Toxicology  

    This study evaluated the toxic effects of water-accommodated fractions (WAFs) of very-low sulfur fuel oil (VLSFO) on freshwater and marine fish embryos. Embryos of Japanese medaka (Oryzias latipes), Java medaka (Oryzias javanicus), and grass puffer (Takifugu alboplumbeus) were exposed to various concentrations of VLSFO-WAF, and the effects on key parameters, such as hatching rate, hatching days, mortality, and malformations, were examined. Exposure of Japanese medaka to 50% WAF significantly reduced hatching rates and increased mortality and malformation rates. Similarly, Java medaka exhibited severe lethality, malformations, and shortened hatching days at 50% WAF. In grass puffer, exposure to 50% WAF caused a sharp increase in post-hatch mortality and malformation rates, although hatching rates remained largely unaffected. The median lethal and median effective concentrations (LC50 and EC50) were 34.8% and 15.6% WAFs for Japanese medaka; 21.3% and 8.8% for Java medaka; and 21.3% and 9.7% for grass puffer, respectively. These WAF-based toxicity endpoints were estimated from quantitatively measured chemical concentrations in the VLSFO and its WAFs: LC50 values of 41.9–68.6 μg/L for ΣPAHs and 213.2–348.3 μg/L for Σalkylated PAHs; and EC50 of 17.3–30.7 μg/L for ΣPAHs and 88.1–156.2 μg/L for Σalkylated PAHs, respectively. This study suggests that polycyclic aromatic hydrocarbons (PAHs) and alkylated PAHs present in VLSFO and its WAF strongly contribute to the observed toxicity. Additionally, VLSFO contains lower concentrations of PAHs than conventional heavy-fuel oils, although it is harmful to certain fish species.

    DOI： 10.1002/tox.70119

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  • Shusaku Fukugami, Masatoshi Yamasaki, Emiko Kokushi, Seiichi Uno .  Differences of benzo[a]anthracene- and pyrene-induced disruption of craniofacial chondrogenesis in Japanese medaka. .  Aquatic toxicology (Amsterdam, Netherlands)291   107696 - 107696   2025.12International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    Polycyclic aromatic hydrocarbons (PAHs) pose developmental risks, specifically craniofacial malformations in fish. This study assessed the effects of benzo [a]anthracene (BaA) and pyrene (Pyr) exposure on craniofacial chondrogenesis in Japanese medaka (Oryzias latipes) embryos, focusing on the roles of aryl hydrocarbon receptor (AhR) and cytochrome P450 (CYP). To explore the involvements with inhibiting craniofacial chondrogenesis, the CYP inhibitor (piperonyl butoxide [PBO]) and AhR antagonist (CH223191 [CH]) were used. Whole-mount Alcian blue staining of hatching larvae revealed that exposure of fish embryos to BaA partially impaired craniofacial chondrogenesis that was further exacerbated by BaA + PBO co-exposure, indicating synergistic effects of BaA under CYP inhibition. Those impairments were accompanied by the downregulation of collagen type II alpha 1a (Col2a1a) and sex-determining region Y-box9b (Sox9b). In contrast, although Pyr exposure also impaired craniofacial chondrogenesis, these effects were not associated with the downregulation of Col2a1a or Sox9b. Notably, both AhR and CYP inhibitions can attenuate Pyr-induced cartilage defects, suggesting that metabolic activation of Pyr is responsible for craniofacial effects. Overall, this study demonstrates that BaA and Pyr disrupt craniofacial chondrogenesis through different toxicological profiles.

    DOI： 10.1016/j.aquatox.2025.107696

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  • Topas Wicaksono Priyo, Naoya Sasazaki, Katsuki Toda, Hiroshi Hasunuma, Daisaku Matsumoto, Emiko Kokushi, Seiichi Uno, Osamu Yamato, Takeshi Obi, Urara Shinya, Oky Setyo Widodo, Yasuho Taura, Tetsushi Ono, Masayasu Taniguchi, Mitsuhiro Takagi .  Effect of Dietary Difructose Anhydride III Supplementation on the Metabolic Profile of Japanese Black Breeding Herds with Low-Level Chronic Exposure to Zearalenone in the Dietary Feed .  Toxins17 ( 8 ) 409 - 409   2025.8

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Mycotoxin contamination in animal feed can cause acute or chronic adverse effects on growth, productivity, and immune function in livestock. This study aimed to evaluate the impact of difructose anhydride III (DFA III) supplementation on serum biochemical parameters and intestinal environment in Japanese Black (JB) breeding cows under low-level chronic dietary exposure to zearalenone (ZEN). Using urinary ZEN concentration as an indicator of exposure, 25 JB cows were selected from a breeding farm with confirmed natural feed contamination. Blood samples were collected before DFA III supplementation (day 0), and on days 20 and 40 post-supplementation. Serum biochemical parameters and short-chain fatty acid concentrations were measured. During the studies, dietary ZEN concentration increased, yet improvements were observed in liver function, nutritional status, immune response, and inflammatory markers. Notably, serum butyrate concentration significantly increased following DFA III administration. These findings suggest that DFA III may positively influence intestinal microflora and enhance intestinal barrier function, which could contribute to improved health and nutritional status in cattle exposed to low-level chronic dietary ZEN contamination. DFA III supplementation may represent a promising strategy for mitigating the effects of low-level mycotoxin exposure in livestock production systems.

    DOI： 10.3390/toxins17080409

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  • Seki Tamaki, Matsuo Jumpei, Kawakami Taisuke, Kokushi Emiko, Uno Seiichi .  Effects evaluation of sertraline exposure on metabolic disturbances in Japanese medaka (<i>Oryzias latipes</i>) .  Japanese Journal of Environmental Toxicology28 ( 1 ) 1 - 11   2025.2

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    Language：Japanese   Publisher：The Japanese Society of Environmental Toxicology  

    <p>Sertraline is an antidepressant belonging to the class of selective serotonin reuptake inhibitors. It is frequently detected in aquatic environment because it cannot be completely degraded in the sewage plants. The effects and mechanisms of sertraline in mammals are well understood. However, its chronic effects in fish have been poorly evaluated. In this study, Japanese medaka (<i>Oryzias latipes</i>) was exposed to sertraline for 14 days, and the effects of sertraline on the fish brain were evaluated using a metabolomics approach. Exposure to 115 µg/L sertraline increased glutamate levels; however, this effect was suggested to be suppressed by several amino acids after 14 days of exposure. The effects in fish exposed to sertraline are unlikely to occur in actual aquatic environments.</p>

    DOI： 10.11403/jset.28.1

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  • Shusaku Fukugami, Masatoshi Yamasaki, Emiko Kokushi, Seiichi Uno. .  Influence of CYP1A and AhR modulation on polycyclic aromatic hydrocarbon-induced developmental defects in Japanese medaka. .  Aquatic Toxicology 280   107267   2025.2Reviewed

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  • Widodo O, Uno S, Kokushi E, Yamato O, Mardianto M, Shinya U, Kano Y, Kawashima C, Fushimi Y, Ono T, Taniguchi M, Takagi M. .  Exposure of Cattle Breeding Herds to Naturally Co-Contaminated Zearalenone and Deoxynivalenol: The Relevance of a Urinary Mycotoxin Monitoring System for Herd Health and Food Safety. .  Toxins.16   402   2024.9Reviewed International coauthorship

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  • Seki, T., Katsura, M., Yamasaki, M., Yamashita, K., Kokushi, E., & Uno, S. .  Effects of diphenhydramine exposure on reproduction of mature Japanese medaka (Oryzias latipes). .  Chemosphere358   142163   2024.5Reviewed

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    Authorship：Corresponding author  

    DOI： https://doi.org/10.1016/j.chemosphere.2024.142163

  • Topas Wicaksono Priyo Jr, Seiichi Uno, Emiko Kokushi, Katsuki Toda, Hiroshi Hasunuma, Daisaku Matsumoto, Osamu Yamato, Masayuki Ohtani, Oky Setyo Widodo, Dhidhi Pambudi, Masayasu Taniguchi, Mitsuhiro Takagi. .  Measurement of serum short-chain fatty acid concentrations in cattle after oral administration of difructose anhydride III. .  Veterinary World16 ( 7 ) 1505 - 1511   2023.5Reviewed International coauthorship

  • Oky Setyo Widodo, Dhidhi Pambudi, Makoto Eto, Emiko Kokushi, Seiichi Uno, Osamu Yamato, Masayasu Taniguchi, Mirni Lamid, Mitsuhiro Takagi. .  Practical application of a urinary zearalenone Monitoring System for Feed Hygiene Management of a Japanese Black Cattle Breeding Herd—Relevance to Anti-Müllerian Hormone and Serum Amyloid A Clarified from a Two-Year Survey. .  Toxins15 ( 5 ) 317   2023.5Reviewed International coauthorship International journal

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI  

    DOI： 10.3390/toxins15050317

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  • Mohd Yusoff Nurulnadia, Baharom Mohamad Zahid, Ku Mohd Kalkausar Ku Yusof, Fatin Izzati Minhat, Seiichi Uno & Hafiz Ikhwan Abdul Hamid. .  Occurrence of octylphenol and nonylphenol in the sediment of South China Sea and Malacca Strait, Peninsular Malaysia. .  Environmental Monitoring and Assessment195   355   2023.2Reviewed International coauthorship

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  • Toxicity evaluations using Japanese medaka embryos in sediments collected from Kahoku-gata, Ishikawa prefecture .    25   48 - 60   2022.8

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    Authorship：Corresponding author   Language：Japanese  

    DOI： https://doi.org/10.11403/jset.25.48

  • Oky Setyo Widodo; Makoto Etoh; Emiko Kokushi; Seiichi Uno; Osamu Yamato; Dhidhi Pambudi; Hiroaki Okawa; Masayasu Taniguchi; Mirni Lamid; Mitsuhiro Takagi .  Practical Application of Urinary Zearalenone Monitoring System for Feed Hygiene Management of a Japanese Black Cattle Breeding Herd—The Relationship between Monthly Anti-Müllerian Hormone and Serum Amyloid A Concentrations .  Toxins14 ( 2 ) 143   2022.2Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/toxins14020143.

  • 仲山 慶, 池田 踏青, 黒川 大輔, 北條 裕也, 宇野 誠一 .  魚類初期生活段階毒性試験の海産魚モデルとしてのクサフグの利用可能性について .  環境毒性学会誌25   1 - 9   2022.1Reviewed

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    Language：Japanese  

  • Validation of a short-term toxicity bioassay using three marine sh species in embryonic to larval stages .    24   70 - 79   2021.12Reviewed

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.11403/jset.24.79

  • Naoya Sasazaki, Seiich Uno, Emiko Kokushi, Katsuki Toda, Hiroshi Hasunuma, Daisaku Matsumoto, Ayaka Miyashita, Osamu Yamato, Hiroaki Okawa, Masayuki Ohtani, Johanna Fink-Gremmels,Masayasu Taniguchi, Mitsuhiro Takagi. .  Mitigation of sterigmatocystin exposure in cattle by difructose anhydride III feed supplementation and detection of urinary sterigmatocystin and serum amyloid A concentrations. .  Arch. Anim. Breed.64   257 - 264   2021.1Reviewed

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    Publishing type：Research paper (scientific journal)  

  • Masato Honda, Koki Mukai, Edward Nagato, Seiichi Uno, Yuji Oshima .  Correlation between Polycyclic Aromatic Hydrocarbons in Wharf Roach (Ligia spp.) and Environmental Components of the Intertidal and Supralittoral Zone along the Japanese Coast. .  International journal of environmental research and public health18 ( 2 ) 1 - 16   2021.1International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    Polycyclic aromatic hydrocarbon (PAH) concentrations in wharf roach (Ligia spp.), as an environmental indicator, and in environmental components of the intertidal and supralittoral zones were determined, and the PAH exposure pathways in wharf roach were estimated. Wharf roaches, mussels, and environmental media (water, soil and sand, and drifting seaweed) were collected from 12 sites in Japan along coastal areas of the Sea of Japan. PAH concentrations in wharf roaches were higher than those in mussels (median total of 15 PAHs: 48.5 and 39.9 ng/g-dry weight (dw), respectively) except for samples from Ishikawa (wharf roach: 47.9 ng/g-dw; mussel: 132 ng/g-dw). The highest total PAH concentration in wharf roach was from Akita (96.0 ng/g-dw), followed by a sample from Niigata (85.2 ng/g-dw). Diagnostic ratio analysis showed that nearly all PAHs in soil and sand were of petrogenic origin. Based on a correlation analysis of PAH concentrations between wharf roach and the environmental components, wharf roach exposure to three- and four-ring PAHs was likely from food (drifting seaweed) and from soil and sand, whereas exposure to four- and five-ring PAHs was from several environmental components. These findings suggest that the wharf roach can be used to monitor PAH pollution in the supralittoral zone and in the intertidal zone.

    DOI： 10.3390/ijerph18020630

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  • Amano H. .  Development of specific enzyme-linked immunosorbent assays for multiple vitellogenins in marbled sole, Pleuronectes yokohamae .  General and Comparative Endocrinology281   67 - 72   2019.9

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    Publisher：General and Comparative Endocrinology  

    DOI： 10.1016/j.ygcen.2019.05.012

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  • Billah M. .  Distribution, Geochemical Speciation, and Bioavailable Potencies of Cadmium, Copper, Lead, and Zinc in Sediments from Urban Coastal Environment in Osaka Bay, Japan .  Water, Air, and Soil Pollution230 ( 7 )   2019.7

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    Publisher：Water, Air, and Soil Pollution  

    DOI： 10.1007/s11270-019-4196-8

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  • Koyama T. .  A SNP in a Steroidogenic Enzyme Is Associated with Phenotypic Sex in Seriola Fishes .  Current Biology29 ( 11 ) 1901 - 1909.e8   2019.6

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    Publisher：Current Biology  

    DOI： 10.1016/j.cub.2019.04.069

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  • BILLAH Md. Masum, KOKUSHI Emiko, UNO Seiichi .  Metal bioavailability and bioaccumulation in the polychaete <i>Perinereis nuntia</i>: relationship between predictions using chemical analysis and accumulation through actual exposures .  環境毒性学会誌22 ( 2 ) 41 - 52   2019

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    Publisher：日本環境毒性学会  

    <p>In the present study, we have examined whether the predicted bioavailability for heavy metals in sediments obtained through chemical analysis reflected the actual accumulation by the polychaete, <i>Perinereis nuntia</i>. In this study, <i>P. nuntia</i> was exposed to sediments collected from two sites of Kagoshima Bay, Japan, for 28 days. The polychaete adsorbed metals such as copper (Cu) and zinc (Zn) from sediments. Biomagnification factors from sediment to polychaete for Cu and Zn were 0.002–0.052 and 0.062–0.066, respectively, and Zn tended to be in higher concentrations in polychaete than Cu. Additionally, we measured metal content in geochemical fractions to predict the bioavailability through chemical analysis and was found to be 2–4% for Cu, and 16–21% for Zn. The prediction of bioavailability through chemical analysis could roughly reflect the actual absorbance of metals in the polychaete. Therefore, we conclude that the prediction of metal bioavailability through geochemical speciation is useful to reliably estimate actual bioaccumulation in the benthic organism.</p>

    DOI： 10.11403/jset.22.41

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  • Kawai Chouji, Kokushi Emiko, Uno Seiichi .  Toxicity Assessment of Coastal Sediments Using Marine Fish .  Marine Engineering54 ( 6 ) 865 - 870   2019

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    Publisher：The Japan Institute of Marine Engineering  

    <p>  Anthropogenic substances reach sea areas, absorb particles and finally pile up on sediments. Although previous studies investigated the distribution of pollutants and detected a high concentration of pollutant residues in Japanese coastal areas, the effects of these residues on benthic organisms have been almost unknown. In fact, methods to assess sediment toxicity have not been established, and it is not easy to assess the toxicity of sediments collected from the sea bottom. In this study, we worked to assess the maximum impact of toxic sediments on benthic organisms by exposing marine medaka to extracts from sediments collected from five sites in Tokyo Bay, Japan. The results showed that sediments collected at two sites caused fatal effects on marine medaka. Furthermore, marine medaka were also exposed to three fractionation processes of varying polarity extracts. The results of these exposure tests indicated the possibility that such sediment extracts may have caused antagonistic effects.</p>

    DOI： 10.5988/jime.54.865

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  • Seki Tamaki, Uno Seiichi .  Metabolomics Approach to Assess Effects of Chemicals on Fish .  Marine Engineering54 ( 6 ) 871 - 874   2019

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    Publisher：The Japan Institute of Marine Engineering  

    <p>  Metabolomics allows for comprehensive assessment of the current state of organisms by collecting information on variations on low₋molecular₋metabolites, which can take different forms to maintain homeostasis even under the influence of chemical exposures or external stressors. Metabolomics workflows include chemical analysis designed to obtain the assessment of metabolites, statistical analysis, research on the metabolic state of organisms and the prediction of their health trajectories. Until now, we have examined and assessed the effects of pollutants on Japanese medaka through the metabolomics approach. In this publication, we describe the metabolomics approach with GC/MS analysis, which includes fish treatment procedures, and its assessment process.</p>

    DOI： 10.5988/jime.54.871

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  • Uno Seiichi, Nakayama Kei, Hashimoto Momoka, Kawai Chouji, Kokushi Emiko .  Toxicity Assessment of Sediments Collected from Hiroshima Bay, Japan, Using Java Medaka Embryos .  Marine Engineering54 ( 6 ) 860 - 864   2019

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    Publisher：The Japan Institute of Marine Engineering  

    <p>The effects of chemicals in sediments in coastal areas on environmental organisms are almost unknown, although a number of investigations on the distribution of pollutants in these sediments were performed, often resulting in the detection of chemical residues with high concentrations. In this study, toxicities of sediments collected from 11 locations in Hiroshima Bay, Japan, was assessed using embryos of Java medaka, <i>Oryzias javanicus</i>. The embryos were placed on sediments containing a little pore water without adding overlying water. The results showed that as high as 37% of the embryos exposed to sediments collected near Hatsukaichi City died. Additionally, the mortality was 33% at a site distant slightly from an industrial area in Otake City. Delayed hatching was observed at six locations. Thus, the certain effects of exposure to sediments collected from the bay in the embryos were observed, and the authors concluded that these effects are most likely to have been caused by chemicals in the sediments. </p>

    DOI： 10.5988/jime.54.860

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  • Toda K. .  Fructo-oligosaccharide (DFA III) feed supplementation for mitigation of mycotoxin exposure in cattle—clinical evaluation by a urinary zearalenone monitoring system .  Toxins10 ( 6 )   2018.6

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    Publisher：Toxins  

    DOI： 10.3390/toxins10060223

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  • Honda M. .  The Wharf Roach, Ligia sp., A Novel Indicator of Polycyclic Aromatic Hydrocarbon Contamination in Coastal Areas .  International Journal of Environmental Research12 ( 1 )   2018.3

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    Publisher：International Journal of Environmental Research  

    DOI： 10.1007/s41742-017-0063-x

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  • Takagi M. .  Measurement of urinary concentrations of the mycotoxins zearalenone and sterigmatocystin as biomarkers of exposure in mares .  Reproduction in Domestic Animals53 ( 1 ) 68 - 73   2018.2

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    Publisher：Reproduction in Domestic Animals  

    DOI： 10.1111/rda.13054

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  • M. Honda, X. Qiu, J. Koyama, S. Uno, SL. Undap, Y. Shimasaki, Y. Oshima .  The wharf roach, Ligia sp.: a novel indicator of polycyclic aromatic hydrocarbon contamination in coastal areas. .  International Journal of Environmental Research.12   1 - 11   2018

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    Language：English   Publishing type：Research paper (scientific journal)  

  • M. Takagi, S. Uno, E, Kokushi, F. Sato, M. M. P. Wijayagunawardane, J. Fink-Gremmels .  Measurement of urinary concentrations of the mycotoxins zearalenone and sterigmatocystin as biomarkers of exposure in mares. .  Reproduction in Domestic Animalsin print   2018Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Kawano M. .  Effects of oxygenated polycyclic aromatic hydrocarbons on the early life stages of Japanese medaka .  Environmental Science and Pollution Research24 ( 36 ) 27670 - 27677   2017.12

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    Publisher：Environmental Science and Pollution Research  

    DOI： 10.1007/s11356-016-6917-5

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  • Uno S. .  Toxic evaluations of sediments in Tokyo Bay, Japan, using Japanese medaka embryos .  Environmental Science and Pollution Research24 ( 36 ) 27702 - 27709   2017.12

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    Publisher：Environmental Science and Pollution Research  

    DOI： 10.1007/s11356-016-7581-5

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  • Kokushi E. .  Evaluation of 2,4-dichlorophenol exposure of Japanese medaka, Oryzias latipes, using a metabolomics approach .  Environmental Science and Pollution Research24 ( 36 ) 27678 - 27686   2017.12

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    Publisher：Environmental Science and Pollution Research  

    DOI： 10.1007/s11356-016-6425-7

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  • 臼井 力, 宇野 誠一, 前田 広人, 吉田 純一 .  食品中の多環芳香族炭化水素に関する調査研究 .  鹿児島県環境保健センター所報 ( 18 ) 47 - 54   2017.12

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    Publisher：鹿児島県環境保健センター  

    発がん性を疑われるベンゾピレン(BaP)を含有する多環芳香族炭化水素(PAH)4を含むPAH16物質の分析法を確立し、市販されている食用植物油脂19検体、さつま揚げ17検体、食肉加工食品15検体のPAH含有量を調査した。その結果、PHA4は食用植物油脂10検体から検出され、そのうち8検体はごま油であった。さつま揚げからは検出されなかった。食肉加工品は燻製・焼き豚9検体からPHA4は検出されなかったが、鶏肉製品6検体全てで高濃度のPHA類が検出され、PHA4総量はEU基準値の24〜66倍、特にBaPはEU基準値の55〜176倍であった。また、市販の活性炭6種類を用いて菜種油中のPAH除去効果を検討した結果、活性炭の粒径が小さいほどPAH除去率が高い傾向であった。

  • Uno S. .  Distributions of nitrated polycyclic aromatic hydrocarbons in the sediment of Osaka Bay, Japan .  Marine Pollution Bulletin124 ( 2 ) 1014 - 1019   2017.11

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    Publisher：Marine Pollution Bulletin  

    DOI： 10.1016/j.marpolbul.2017.02.062

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  • Bacolod E.T. .  Oxidative stress and genotoxicity biomarker responses in tilapia (Oreochromis niloticus) exposed to environmental concentration of 1-nitropyrene .  Marine Pollution Bulletin124 ( 2 ) 786 - 791   2017.11

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    Publisher：Marine Pollution Bulletin  

    DOI： 10.1016/j.marpolbul.2017.01.077

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  • Uno S. .  Oil spill off the coast of Guimaras Island, Philippines: Distributions and changes of polycyclic aromatic hydrocarbons in shellfish .  Marine Pollution Bulletin124 ( 2 ) 962 - 973   2017.11

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    Publisher：Marine Pollution Bulletin  

    DOI： 10.1016/j.marpolbul.2017.03.062

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  • Toda K. .  Gas chromatography-mass spectrometry for metabolite profiling of Japanese black cattle naturally contaminated with zearalenone and sterigmatocystin .  Toxins9 ( 10 )   2017.10

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    Publisher：Toxins  

    DOI： 10.3390/toxins9100294

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  • S. Uno, E. Kokushi, M. Kawano, A.E. McElroy, J. Koyama .  Toxic evaluations of sediments in Tokyo Bay, Japan, usingJapanese medaka embryos. .  Environ. Sci. Pollut. Res.24 ( 36 ) 27702 - 27709   2017Reviewed

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  • E. Kokushi, A. Shintoyo, J. Koyama, S. Uno .  Evaluation of 2,4-dichlorophenol exposure of Japanese medaka, Oryzias latipes, using a metabolomics approach. .  Environ. Sci. Pollut. Res.24 ( 36 ) 27678 - 27686   2017Reviewed

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  • M. Kawano, S. Uno , J. Koyama, E. Kokushi, A. McElroy .  Effects of oxygenated polycyclic aromatic hydrocarbons on the early life stages of Japanese medaka. .  Environ. Sci. Pollut. Res. 24 ( 36 ) 27670 - 27677   2017

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  • K. Toda, E. Kokushi, S. Uno, A. Shiiba, H. Hasunuma, Y. Fushimi, M. P. B. Wijayagunawardane, C. Zhang, O. Yamato, M. Taniguchi, J. Fink-Gremmels, M. Takagi .  Gas chromatography-mass spectrometry for metabolite profiling of Japanese black cattle naturally contaminated with zearalenone and sterigmatocystin. .  Toxins9   294 - 307   2017Reviewed

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  • E. T. Bacolod, S. Uno, S. S. Villamor, J. Koyama .  Oxidative stress and genotoxicity biomarker responses in tilapia (Oreochromis niloticus) exposed to environmental concentration of 1-nitropyrene. .  Marine Pollution Bulletin124   786 - 791   2017Reviewed

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  • S. Uno, E. Kokushi, N. C. Añasco, T. Iwai, K. Ito, J. Koyama .  Oil spill off the coast of Guimaras island, Philippines: distributions and changes of polycyclic aromatic hydrocarbons in shellfish. .  Marine Pollution Bulletin124   962 - 973   2017Reviewed

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  • S. Uno, H. Tanaka, E. Kokushi, E. T. Bacolod, J. Koyama .  Distributions of nitrated polycyclic aromatic hydrocarbons in the sediment of Osaka Bay, Japan. .  Marine Pollution Bulletin124   1014 - 1019   2017Reviewed

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  • Nurulnadia M.Y. .  Bioaccumulation of sedimentary endocrine disrupting chemicals (EDCs) by the benthic fish, Pleuronectes yokohamae .  Malaysian Journal of Analytical Sciences21 ( 3 ) 535 - 543   2017

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    Publisher：Malaysian Journal of Analytical Sciences  

    DOI： 10.17576/mjas-2017-2103-03

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  • M. Y. Nurulnadia, J. Koyama, S. Uno, H. Amano .  Biomagnification of endocrine disrupting chemicals (EDCs) by Pleuronectes yokohamae: Does P. yokohamae accumulate dietary EDCs? .  Chemosphere144   185 - 192   2016.1

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  • J. Koyama, S. Uno, Y. Nagai, B. Anukorn .  Early monitoring of spilled oil contamination in Rayong, Thailand. .  Japanese Journal of Environmental Toxicology.19   25 - 33   2016Reviewed

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  • J. Koyama, S. Nigaya, A. Takenouchi, E. Kokushi, S. Uno .  Bioaccumulation of environmental organotin compounds in translocated rock shell Thais clavigera in Kagoshima Bay. .  Fishries Science82   975 - 982   2016Reviewed

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  • K Ito, S Uno, H Tanaka, S Miki, E Kokushi, M Yamamoto, J Koyama, N C Anasco .  Distribution of parent and alkylated PAHs in bivalves collected from Osaka Bay, Japan. .  Japanese Journal of Environmental Toxicology18   11 - 24   2015.12Reviewed

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  • 河野真知、宇野誠一、國師恵美子、小山次朗 .  ゲンタマイシン腹腔内暴露により腎障害を誘発したコイの血漿中代謝物変動 .  環境毒性学会誌18   25 - 37   2015.12Reviewed

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  • Y. Fushimi, M. Takagi, D. Monniaux, S. Uno, E. Kokushi, U. Shinya, C. Kawashima, T. Otoi, E. Deguchi, J. Fink-Gremmels .  Effects of dietary contamination by zearalenone and its metabolites on serum anti-müllerian hormone: impact on the reproductive performance of breeding cows. .  Reproduction in Domestic Animals50   834 - 839   2015.1Reviewed

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  • Yasuo Fushimi, Mitsuhiro Takagi, Seiichi Uno, Emiko Kokushi, Masayuki Nakamura, Hiroshi Hasunuma, Urara Shinya, Eisaburo Deguchi, Johanna Fink-Gremmels .  Measurement of Sterigmatocystin Concentrations in Urine for Monitoring the Contamination of Cattle Feed. .  Toxins6   3117 - 3128   2014.1Reviewed

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  • Nunal, S. N., Santander-de, L., Sheila, M. S., Bacolod, E., Koyama, J., Uno, S., Hidaka, M., Yoshikawa, T., Maeda, H. .  Bioremediation of Heavily Oil-Polluted Seawater by a Bacterial Consortium Immobilized in Cocopeat and Rice Hull Powder. .  Biocontrol Science. 19 ( 1 ) 11 - 22   2014.1Reviewed

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  • S. Miki, S. Uno (double author), K. Ito, J. Koyama, H. Tanaka. .  Distributions of polycyclic aromatic hydrocarbons and alkylated polycyclic aromatic hydrocarbons in Osaka Bay, Japan. .  Mar. Poll. Bull.85   487 - 493   2014.1Reviewed

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  • M. Y. Nurulnadia, J. Koyama, S. Uno, A. Kito, E. Kokushi, E. T. Bacolod, K. Ito, Y. Chuman. .  Accumulation of endocrine disrupting chemicals (EDCs) in the polychaete Paraprionospio sp. from the Yodo River mouth, Osaka Bay, Japan. .  Environ Monit Assess. 186   1453 - 1463   2014.1Reviewed

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  • Y. Fushimi, M. Takagi, H. Hasunuma, S. Uno, E. Kokushi, U. Watanabe, J. Liu, M. Marey, A. Miyamoto, T. Otoi, E. Deguchi, and J. Fink-Gremmels. .  Application of mycotoxin adsorbent to cattle herd naturally contaminated with zearalenone: Urinary zearalenone excretion and association with anti-Mullerian hormone. .  Word Mycotoxin J.7   367 - 378   2014.1Reviewed

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  • S. Dasgupta, A. Cao, B. Mauer, B. Yan, S. Uno, A. McElroy. .  Genotoxicity of oxy-PAHs to Japanese medaka (Oryzias latipes) embryos assessed using the comet assay. .  Environ. Sci. Pollut. Res. 21   13867 - 13876   2014.1Reviewed

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  • J. Koyama, C. Imakado, S. Uno, T. Kuroda, S, Hara, T. Majima, H. Shirota, N. C. Anasco. .  Simulated Distribution and Ecotoxicity-Based Assessment of Chemically-Dispersed Oil in Tokyo Bay. .  Mar. Poll. Bull.85   487 - 493   2014.1Reviewed

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  • T. B. Eugene, S. Uno, H. Tanaka, S. Miki, E. Kokushi, M. Fukunaga, J. Koyama. .  Bioconcentration of waterborne nitroarenes in marbled flounder Pleuronectes yokohamae. .  Jpn. J. Environ. Toxicol. 16   91 - 105   2013.12Reviewed

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  • T. B. Eugene, S. Uno, H. Tanaka, J. Koyama. .  Micronuclei and nuclear abnormalities induction in erythrocytes of marbled flounder, Pleuronectes yokohamae, exposed to dietary nitrated polycyclic aromatic hydrocarbons. .  Jpn. J. Environ. Toxicol. 16   79 - 89   2013.12Reviewed

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  • Sambuu R, Takagi M, Namula Z, Nii M, Taniguchi M, Uno S, Kokushi E, Tshering C, Santos RR, Fink-Gremmels J, OTOI T, .  Effects of long-term in vitro exposure of ejaculated boar sperm to zearalenone and α-zearalenol in sperm liquid storage medium. .  Animal Science Journal 84   28 - 34   2013.1Reviewed

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  • E. Kokushi, S. Uno, S. Pal, J. Koyama .  Effects of Chlorpyrifos on the Metabolome of the Freshwater Carp, Cyprinus Carpio. .  Environmental toxicology30   253 - 260   2013.1Reviewed

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  • M. Y. Nurulnadia, J. Koyama, S. Uno, E. Kokushi, E. T. Bacolod, K. Ito, Y. Chuman .  Bioaccumulation of Dietary Endocrine Disrupting Chemicals (EDCs) by the Polychaete, Perinereis nuntia. .  Bull. Environ. Contam. Toxicol.91 ( 4 ) 372 - 376   2013.1Reviewed

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  • 國師恵美子，宇野誠一，小山次朗 .  コイ血漿メタボロミクスによるカーバメート系殺虫剤BPMCの有害性評価 .  環境毒性学会誌16 ( 1 ) 1 - 11   2013.1Reviewed

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  • M. Takagi, T. Hirai, S. Shiga, S. Uno, E. Kokushi, T. Otoi, E. Deguchi, C. Tshering. .  Relationship between urinary zearalenone concentration and embryo production in superovulated cattle. .  Archives Animal Breeding36   360 - 366   2013.1Reviewed

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  • M.Takagi, S. Shiga, S. Uno, E. Kokushi, T. Otoi, C. Tshering, E. Deguchi, J. Fink-Gremmels. .  Periodic Alteration in Urinary Zearalenone Excretion in a Dairy Cattle Herd. .  Animal Nutrition and Feed Technology.13   303 - 310   2013.1Reviewed

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  • J. Koyama, A. Kitoh, M. Nakai, K. Kohno, H. Tanaka, S. Uno .  Relative Contribution of Endocrine-disrupting Chemicals to the Estrogenic Potency of Marine Sediments of Osaka Bay, Japan. .  Water Air Soil Pollut224   1570 - 1579   2013.1Reviewed

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  • Sambuu R, Takagi M, Namula Z, Nii M, Taniguchi M, Uno S, Kokushi E, Tshering C, dos Santos RR, Fink-Gremmels J, Otoi T. .  Effects of long-term in vitro exposure of ejaculated boar sperm to zearalenone and α-zearalenol in sperm liquid storage medium. .  Animal science journal 84 ( 1 ) 28 - 34   2013.1Reviewed

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  • Nurulnadia MY, Koyama J, Uno S, Kito A, Kokushi E, Bacolod ET, Ito K, Chuman Y. .  Accumulation of endocrine disrupting chemicals (EDCs) in the polychaete Paraprionospio sp. from the Yodo River mouth, Osaka Bay, Japan. .  Environmental monitoring and assessment.in press   2013Reviewed

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  • Mohd Yusoff Nurulnadia, Jiro Koyama, Seiichi Uno, Emiko Kokushi, Eugene Tan Bacolod, Kazuki Ito, Yasutaka Chuman .  Bioaccumulation of Dietary Endocrine Disrupting Chemicals (EDCs) by the Polychaete, Perinereis nuntia .  Bull Environ Contam Toxicol91   372 - 376   2013Reviewed

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  • Emiko Kokushi, Seiichi Uno,Sandipan Pal,Jiro Koyama, .  Effects of chlorpyrifos on the metabolome of the Freshwater Carp, Cyprinus carpio .  Environ Toxicolin press   2013Reviewed

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  • S. Pal, E. Kokushi, J. Koyama, S. Uno, A. R. Ghosh .  Histopathologicalalterations in gill, liver and kidney of common carp exposed to chlorpyrifos .  Journal of Environmental Science and Health, Part B: Pesticides47   180 - 195   2012.1Reviewed

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  • Seiichi Uno, Aoi Shintoyo, Emiko Kokushi, Masataka Yamamoto, Kei Nakayama, Jiro Koyama .  Gas chromatography-mass spectrometry for metabolite profiling of Japanese medaka (Oryzias latipes) juveniles exposed to malathion .  Environmental Science and Pollution Research19   2595 - 2605   2012.1Reviewed

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  • J. Koyama, A. Takenouchi, S. Nigaya, E. Kokushi, S. Uno .  Organotin residues in Rock Shell, Thais clavigera, and their sources in Kagoshima Bay, Japan. .  Aquatic Ecosystem Health & Management.15   260 - 266   2012.1Reviewed

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  • Hasunuma, H., Takagi, M., Shiga, S., Uno, S., Kokushi, E., Mukai, S., Kuriyagawa, T., Takagaki, K., Matsumoto, D., Okamoto, K., Deguchi, E., and Fink-Gremmels, J. .  Monitoring Natural Feed Contamination in Beef Cattle by Measurements of Urinary Zearalenone Concentrations after Oral Administration of Mycotoxin Adsorbents as a top Dressing. .  Journal of Applied Animal Research39 ( 3 ) 292 - 295   2011.9Reviewed

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  • Seiichi Uno, Masayo Murakami, Emiko Kokushi, Jiro Koyama .  Inter-Species Differences in the Accumulation of Tributyltin and its Metabolites under Dietary Exposure in Sea perch, Lateolabrax japonicus, and Red Sea Bream, Pagrus major. .  Environ. Toxicol.26   29 - 36   2011.1Reviewed

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  • Harold Modoc Monteclaro, Kazuhiko Anraku, Seiichi Uno, Jiro Koyama, Tatsuro Matsuoka, Hong Young Yan .  Sensitivity of crayfish antennules to hydrodynamic stimuli is reduced during diazinon exposure .  Zoological Studies50   145 - 154   2011.1Reviewed

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  • Rentsenkhand Sanbuu, Mitsuhiro Takagi, Satoshi Shiga, Seiichi Uno, Emiko Kokushi, Zhao Namula, Takeshige Otoi, Akio Miyamoto, Eisaburo Deguchi, and Johanna Fink-Gremmels .  Detection of Zearalenone and Its Metabolites in Naturally Contaminated Porcine Follicular Fluid by Using Liquid Chromatography Tandem Mass Spectrometry. .  J. Reprod. Dev.57   303 - 306   2011.1Reviewed

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  • M. Takagi, S. Uno, E. Kokushi, S. Shiga, S. Mukai, T. Kuriyagawa, K. Takagaki, H. Hasunuma, D. Matsumoto, K. Okamoto, F. Shahada, T. Chenga, E. Deguchi, and J. Fink-Gremmels .  Measurement of urinary zearalenone concentrations for monitoring natural feed contamination in cattle herds - on-farm trials .  J. Anim. Sci. 89   287 - 296   2011.1Reviewed

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  • 國師恵美子、宇野誠一、小山次朗 .  1H-NMRメタボローム解析を用いた絶食下コイCyprinus carpio L. の血漿中代謝物変動評価 .  日本水産学会誌77 ( 1 ) 75 - 83   2011.1Reviewed

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  • Emiko Kokushi, Seiichi Uno, Tomohiro Harada, Jiro Koyama .  1H-NMR based Metabolomics Approach to Assess Toxicity of Bunker A Heavy Oil to Freshwater Carp .  Eviron. Toxicol.in print   2011.1Reviewed

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  • Seiichi Uno, Hiroyuki Tanaka, Shizuho Miki, Emiko Kokushi, Kazuki Ito, Masataka Yamamoto and Jiro Koyam .  Bioaccumulation of nitroarenes in bivalves at Osaka Bay, Japan .  Marine Pollution Bulletine63 ( 42136 ) 477 - 481   2011.1Reviewed

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  • Sandipan Pal, Emiko Kokushi, Joseph O.Cheikyula, Jiro Koyama, Seiichi Uno .  Histopathological effects and EROD induction in common carp exposed to dietary heavy oil. .  Ecotoxicology and Environmental Safety74   307 - 314   2011.1Reviewed

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  • Hasunuma H., Takagi M., Kawamura O., Taniguchi C., Nakamura M., Chuma T.,Uno S., Kokushi E., Matsumoto D., Tshering C., Deguchi E. and Fink-Gremmels J. .  Natural contamination of dietary rice straw with zearalenone and urinary zearalenone concentrations in a cattle herd. .  J Anim Sciin press   2011.1Reviewed

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  • J. Song, K. Nakayama, E. Kokushi, K. Ito, S. Uno, J. Koyama, H. Rahman, Y. Murakami, S. Kitamura .  Effect of heavy oil exposure on antibacterial activity and expression of immune-related genes in Japanese flounder Paralichthys olivaceus .  Environmental Toxicology and Chimistryin print   2011.1Reviewed

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  • Nathaniel C. Anasco, Jiro Koyama, Seiichi Uno .  Pesticide Residues in Coastal Waters Affected by Rice Paddy Effluents Temporarily Stored in a Wastewater Reservoir in Southern Japan .  Archives of Environmental Contamination and Toxicology58   352 - 360   2010.1Reviewed

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  • Shizuho Miki, Jiro Koyama, Seiichi Uno .  Optimization of pressurized liquid extraction for simultaneous analysis of polycyclic aromatic hydrocarbons and alkylated polycyclic aromatic hydrocarbons in sediments. .  Fresen. Environ. Bull.19   1544 - 1551   2010.1Reviewed

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  • Seiichi Uno, Jiro Koyama, Emiko Kokushi, Harold Monteclaro, Sheryll Santander, J. Orkuma Cheikyula, Shizuho Miki, Nathaniel Anasco, Ida G. Pahila, Hilario S. Taberna Jr., Tatsuro Matsuoka .  Monitoring of PAHs and Alkylated PAHs in Aquatic Organisms after One Month from Solar I Oil Spill off the Coast of Guimaras Island, Philippines .  Environmental Monitoring and Assessment165   501 - 515   2010.1Reviewed

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  • Nathaniel Anasco, Seiichi Uno, Jiro Koyama, Tatsuro Matsuoka, Naoya Kuwahara .  Assessment of Pesticide Residues in Freshwater Areas Affected by Rice Paddy Effluents in Southern Japan .  Environmental Monitoring and Assessment160   371 - 383   2010.1Reviewed

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  • Uno,Seiichi,Kokushi Emiko,Pahila Ida G.,Koyama Jiro .  Changings of Polycyclic Aromatic Hydrocarbons in Aquatic Organisms and Sediment at Guimaras after Oil Spill .  鹿児島大学水産学部紀要特別号   63 - 66   2010.1

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  • Yoshikawa, Takeshi,Murata, Kei,Uno, Seiichi,Koyama, Jiro,Maeda, Hiroto,Hayashi, Masazumi,Sadaba, Resurreccion B .  Biodegradation of Heavy C Oil by Alcanivorax sp. a1 Strain Isolated from Recovered Bunker Oil Spilt in the “Solar I” Accident .  鹿児島大学水産学部紀要特別号   67 - 73   2010.1

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  • Monteclaro, Harold,Anraku, Kazuhiko,Uno, Seiichi,Koyama, Jiro,Matsuoka, Tatsuro,Quinitio, Gerald F. .  Water Quality Degradation and its Effect on Fishing Activities .  鹿児島大学水産学部紀要特別号   47 - 51   2010.1

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  • Pahila, Ida G.,Taberna, Hilario Jr.,Sadaba, Resurreccion Jr.,Gamarcha, Leandro,Koyama, Jiro,Uno, Seiichi .  Assessment of Residual Petroleum Hydrocarbon Two Years After the M/T Solar I Oil Spill in Southern Guimaras, Central Philippines .  鹿児島大学水産学部紀要特別号   59 - 62   2010.1

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  • 江幡恵吾、宇野誠一、吉川毅、丸儀雅孝、東輝、谷和博、塩満曉洋、税所誠一、池田利光、若松憲二郎、達山智成、川井田博 .  焼酎粕を有効活用したコンクリート魚礁の開発 .  鹿児島大学水産学部紀要特別号   66 - 71   2010.1

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  • Jiro Koyama, Masayo Murakami, Seiichi Uno .  Immunotoxicity of tributyl tin to Japanese sea bass, Lateolabrax japonicus and red sea bream, Pagrus major, in relation to their body burden .  Jpn. J. Environ. Toxicol,12   123 - 133   2009.1Reviewed

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  • Cheikyula, J. O., Koyama, J., Uno, S. .  S. Comparative study of Bioconcentration and EROD activity induction in the Japanese flounder, red sea bream, and Java medaka exposed to polycyclic aromatic hydrocarbons, Environmental Toxicology. .  Environmental Toxicology23   354 - 362   2008.1Reviewed

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  • Jiro Koyama, Miki Kawamata, Shoko Imai, Miho Fukunaga, Seiichi Uno, Akira Kakuno .  Java medaka: a proposed new marine test fish for ecotoxicology .  Environmental Toxicology23   354 - 362   2008.1Reviewed

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  • J.Orkuma Cheikyula, Jiro Koyama, Seiichi Uno .  Micronuclei and other Nuclear Abnormalities Formation in the Red Sea Bream, Pagrus major, Exposed to Polycyclic Aromatic Hydrocarbons .  Jpn.J.Environ.Toxicol.12   33 - 39   2008.1Reviewed

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  • Mitsuhiro Takagi, Shuhei Mukai, Toshiyuki Kuriyagawa, Katsuhito Takagaki, Seiichi Uno, Emiko Kokushi, Takeshige Otoi, Agung Budiyanto, Koumei Shirasuna, Akio Miyamoto, Osamu Kawamura, Koji Okamoto, Eisaburo Deguchi .  Detection of zearalenone and its metabolites in naturally contaminated follicularfluids by using LC/MS/MS and in vitro effects of zearalenone on oocyte maturation in cattle .  Reproductive Toxicology26   164 - 169   2008.1Reviewed

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  • 宇野誠一、國師恵美子、小山次朗 .  魚類血漿を用いた有害化学物質の1H-NMRメタボロミクス影響評価 .  環境毒性学会誌11   63 - 67   2008.1Reviewed

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  • J. Orkuma Cheikyula, Jiro Koyama, Seiichi Uno .  Bioaccumulation of dietary polycyclic aromatic hydrocarbons and EROD induction in the red sea bream and Java medaka .  Jpn.J.Environ.Toxicol.11   99 - 115   2008.1Reviewed

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  • Seiichi Uno, Emiko Kokusi, Shizuho Miki, Nathaniel C. Anasco, Jiro Koyama, Harold Monteclaro .  Preliminary survey of chemical pollution in coastal area of Panay Iskand, Philippines. .  UPV J.Nat.Sci.12   9 - 24   2007.1

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  • Jiro Koyama, Seiichi Uno, Kumiko Kohno .  Polycyclic aromatic hydrocarbon contamination and recovery characteristics in some organisms after the Nakhodka oil spill. .  Marine pollution Bulletin.49 ( 11月12日 ) 1054 - 1061   2004.1Reviewed

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  • Yutaka Okumura, Jiro Koyama, Seiichi Uno .  The relationship between logPow and molecular weight of polycyclic aromatic hydrocarbons and EC50 values of marine microalgae .  La mer41   182 - 191   2003.1Reviewed

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  • Seiichi Uno, Jiro Koyama, Kumiko Ikeda .  Polycyclic aromatic hydrocarbons in liver and their metabolites in bile of founder (Paralichthys oivevaceus) orally exposed to crude oil and heavy fuel oil. .  Jpn. J. Environ. Toxicol.6   53 - 64   2003.1Reviewed

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  • T. Horiguchi, Z. Li, S. Uno, M. Shimizu, H. Shiraishi, M. Morita, J.A.J. Thompson, C.D. Levings .  Contamination of organotin compounds and imposex in mollusks from Vancouver, Canada. .  Marine Environmental Research57   75 - 88   2003.1Reviewed

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  • 宇野誠一、小山次朗、田中博之、山田久、白石寛明 .  超臨界抽出法を用いた魚介類中の有機塩素系農薬の分析 .  環境化学会誌13   427 - 437   2003.1Reviewed

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  • Seiichi Uno, Jiro Koyama, Hisashi Yamada .  Organochlorine and polyaromatic hydrocarbon residues in English sole, Pleuronectes vetulus, at Vancouver Harbour .  PICES Scientific Report16   30 - 35   2001.1

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  • Seiichi Uno, Hiroaki Shiraishi, Shigehisa Hatakeyama, Akira Otsuki, Jiro Koyama .  Accumulative characteristics of pesticide residues in organs of bivalves (Anodonta Woodiana and Corbicula leana) under natural conditions .  Arch. Environ. Contam. Toxicol.40   35 - 47   2001.1Reviewed

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  • Seiichi Uno, Jiro Koyama, Hisashi Yamada .  Organochlorine and polyaromatic hydrocarbon residues in bivalves at Vancouver Harbour. .  PICES Scientific Report16   35 - 42   2001.1

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  • Toshihiro Horiguchi, Seiichi Uno, Makoto Shimizu, Hiroaki Shiraishi, Masatoshi Morita .  Contamination of organotin compounds and imposex in mollusks from Vancouver, Canada .  PICES Scientific Report16   53 - 56   2001.1

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  • Seiichi Uno, Yun, Ji Hyun, Masaki Kaneniwa, Jiro Koyama, Hisashi Yamada, Kumiko Ikeda .  Lipid class and fatty acid composition of mussel, Mytilus trossulus, Vancouver Harbour .  PICES Scientific Report16   43 - 47   2001.1

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  • Shigehisa Hatakeyama, Hiroaki Shiraishi, Seiichi Uno .  Overall pesticide effects on growth and emergence of two species of Ephemeroptera in a model stream carrying pesticide-polluted river water .  Ecotoxicology6   167 - 180   1997.1Reviewed

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  • Seiichi Uno, Hiroaki Shiraishi, Shigehisa Hatakeyama, Akira Otsuki .  Uptake and depuration kinetics and BCFs several pesticides in three species of shellfish (Corbicula leana, Corbicula Japonica, and Cipangopludina chinensis): Comparison between field and laboratory experiment. .  Aquatic Toxicology39   23 - 43   1997.1Reviewed

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  • Seiichi Uno, Hiroaki Shiraishi, Shigehisa Hatakeyama, Akira Otsuki .  Histological changes in gills of freshwater shellfish induced by pesticides. .  日米農薬残留ワークショップ－プロシーディング   152 - 157   1997.1

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Books

  • Toxicological Effects of Heavy Oil on Carp by NMR-based Metabolic Profiling of Plasma.

    Seiichi Uno, Emiko Kokushi, Jiro Koyama（ Role： Joint author）

    Interdisciplinary Studies on Environmental Chemistry-Biological Responses to Chemical Pollutants, Eds., Y. Murakami, K. Nakayama, S.-I. Kitamura, H. Iwata and S. Tanabe by TERRAPUB  2008.1 

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    Language：English Book type：Scholarly book

  • 化学物質の生態リスク評価と規制-農薬編ー３．３貝類の農薬類生物濃縮

    編著者：畠山成久（ Role： Joint author）

    日本環境学会監修アイピーシー発行  2006.1 

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MISC

  • Immune responses of fish T cells to non-toxic AhR ligands

    山崎雅俊, 仲山慶, 北村真一, 藤田皓然, 福上周作, 安本信哉, 宇野誠一

    日本比較免疫学会学術集会講演要旨   36th   2025

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  • Examinations of interspecific differences for effects between freshwater and marine amphipods exposed to tire wear particles.

    尾藤達宙, 宇野誠一, 山崎雅俊, 國師恵美子, 仲山慶, 鈴木剛

    環境化学討論会要旨集(CD-ROM)   32nd   2024

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  • Evaluation of the Effects of Heavy Oil Polluted Water and Alkylated PAHs on Grass Puffer (Takifugu alboplumbeus) Embryos.

    松尾純平, 山崎雅俊, 國師恵美子, 仲山慶, 宇野誠一

    環境化学討論会要旨集(CD-ROM)   32nd   2024

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  • Field-based ecotoxicity evaluation of chemicals persistent in sediments: a pilot study of combined use of sediment toxicity test and DNA analysis

    仲山慶, 國師恵美子, 今村和貴, 宇野誠一

    環境化学討論会要旨集(CD-ROM)   31st   2023

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  • Effects evaluation of tire particles and leachate in marine amphipod, and change of toxicity according to mileage

    山崎雅俊, 宇野誠一, 今村和貴, 尾藤達宙, 小田桐光李, 國師恵美子, 仲山慶, 鈴木剛

    環境化学討論会要旨集(CD-ROM)   31st   2023

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  • 北米で増加する奇形カエル

    宇野誠一

    化学と工業   51   920   1998.1

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations

  • Uno S, Nakayama K, Kitamura S-I, Murakami Y, Kokushi E, Shintoyo A, Ito K, Koyama J.   Toxicity evaluations for individual and mixed exposures of phenanthrene and pyrene in medaka (Oryzias latipes) alevin with metabolomics and transcriptomics   International conference

    International Conference on Environmental OMICS  International Conference on Environmental OMICS

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    Event date： 2011.11

    Language：English  

    Venue：中国  

    国際学会

  • Nakayama K, Uno S, Kokushi E, Koyama J, Handoh IC, Kitamura S-I.   Transcriptomic and metabolomic changes caused by the effects of single and combined environmental stressors   International conference

    International Conference on Environmental OMICS  International Conference on Environmental OMICS

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    Event date： 2011.11

    Language：English  

    Venue：中国  

    国際学会

  • 新野 竜大、宇野 誠一   医薬品の生態毒性評価-作用機序に基づく新たな視点の必要性  

    日本水環境学会シンポジウム  日本水環境学会シンポジウム

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    Event date： 2011.11

    Language：Japanese  

    Venue：宮城  

    国内学会

  • 仲山 慶，宇野誠一，半藤逸樹，北村真一   複合的な環境要因に対する生体応答の検出と影響の評価  

    衛生薬学・環境トキシコロジー  衛生薬学・環境トキシコロジー

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    Event date： 2011.10

    Language：Japanese  

    Venue：石川  

    国内学会

  • 宇野誠一，仲山 慶，北村真一，國師恵美子，新豊 葵，小山次朗   PAH類に暴露したヒメダカ稚魚のメタボロームとトランスクリプトームの変動の比較  

    第17回日本環境毒性学会・バイオアッセイ研究会合同研究発表会  第17回日本環境毒性学会・バイオアッセイ研究会合同研究発表会

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    Event date： 2011.9

    Language：Japanese  

    Venue：鹿児島  

    国内学会

  • 仲山 慶，宇野誠一，國師恵美子，新豊 葵，小山次朗，村上安則，北村真一   多環芳香族炭化水素の単独・複合暴露に対する生体応答の解析  

    第17回日本環境毒性学会・バイオアッセイ研究会合同研究発表会  第17回日本環境毒性学会・バイオアッセイ研究会合同研究発表会

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    Event date： 2011.9

    Language：Japanese  

    Venue：鹿児島  

    国内学会

  • Uno S, Nakayama K, Nino T, Kokushi E, Koyama J.   Metabolomics approach to evaluate effects of environmental contaminants in fish   International conference

    International Symposium on Advanced Studies by Young Scientists on Environmental Pollution and Ecotoxicology  International Symposium on Advanced Studies by Young Scientists on Environmental Pollution and Ecotoxicology

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    Event date： 2011.8

    Language：English  

    Venue：愛媛  

    国際学会

  • S. Uno, A. Shintoyo, E. Kokushi, M. Yamamoto1 and J. Koyama   METABOLIC PROFILING OF JAPANESE MEDAKA (ORYZIAS LATIPES) EXPOSED TO ORGANOPHOSPHOROUS PESTICIDE USING GAS CHROMATOGRAPHY MASS SPECTROMETRY   International conference

    15th International Symposium on Toxicity Assessment (ISTA15)  15th International Symposium on Toxicity Assessment (ISTA15)

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    Event date： 2011.7

    Language：English  

    Venue：香港  

    国際学会

  • Uno S, Nakayama K, Kokushi E, Shintoyo A, Yamamoto M, Murakami Y, Kitamura SI, Koyama J.   Toxicity assessment of polycyclic aromatic hydrocarbon mixtures in Japanese medaka (Oryzias latipes) based on metabolomic analyses.   International conference

    15th International Symposium on Toxicity Assessment (ISTA15)  15th International Symposium on Toxicity Assessment (ISTA15)

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    Event date： 2011.7

    Language：English  

    Venue：香港  

    国際学会

  • Nakayama K, Uno S, Kokushi E, Shintoyo A, Yamamoto M, Koyama J, Murakami Y, Kitamura SI   Toxicity assessment of polycyclic aromatic hydrocarbon mixtures in Japanese medaka (Oryzias latipes) based on transcriptomic data   International conference

    15th International Symposium on Toxicity Assessment (ISTA15)  15th International Symposium on Toxicity Assessment (ISTA15)

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    Event date： 2011.7

    Language：English  

    Venue：香港  

    国際学会

  • 國師 恵美子，宇野誠一，小山次朗   コイ（Cyprinus carpio）の尿を用いたGC/MSメタボロミクスによるクロルピリホスの有害性評価  

    第20回環境化学討論会  第20回環境化学討論会

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    Event date： 2011.7

    Language：Japanese  

    Venue：熊本  

    国内学会

  • 宇野誠一，新野竜大，大堀祐司，國師 恵美子，小山次朗   メタボロミクスを用いたメダカ（Oryzias latipes）の胚に対するクロロフェノール類の影響評価  

    第20回環境化学討論会  第20回環境化学討論会

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    Event date： 2011.7

    Language：Japanese  

    Venue：熊本  

    国内学会

  • Eugene T. BACOLOD, Seiichi UNO, Jiro KOYAMA   Accumulation &amp; toxicity in marbled flounder, Pleuronectes yokohamae, exposed to dietary nitroarenes  

    H23日本水産学会春期大会  H23日本水産学会春期大会

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    Event date： 2011.3

    Language：Japanese  

    Venue：東京  

    国内学会

  • 宇野誠一・木藤麻美・小山次朗・田中博之   内湾底質のエストロゲン様物質分布とその生物濃縮  

    H23日本水産学会春期大会  H23日本水産学会春期大会

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    Event date： 2011.3

    Language：Japanese  

    Venue：東京  

    国内学会

  • Nakayama K, Uno S, Kokushi E, Handoh IC, Kitamura SI.   Transcriptome and metabolome changes by multiple environmental stressors.   International conference

    SETAC North America 31st Annual Meeting  SETAC North America 31st Annual Meeting

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    Event date： 2010.11

    Language：English  

    Venue：米国  

    国際学会

  • S. Uno, E. Kokushi, H. Monteclaro, S. Santander, I. G. Pahila, J. Koyama   Monitoring of oil pollution recovery in shellfish and sediment in Guimaras Island, Philippines after Solar I tanker oil spill   International conference

    SETAC North America 31st Annual Meeting  SETAC North America 31st Annual Meeting

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    Event date： 2010.11

    Language：English  

    Venue：米国  

    国際学会

  • Seiichi Uno, Emiko Kokushi, Masataka Yamamoto, Tatsuhiro Niino, Yuji Ohori, Jiro Koyama   Toxicity assessment of dichlorophenols on medaka (Oryzias latipes) embryo by metabolomics approach   International conference

    SETAC North America 31st Annual Meeting  SETAC North America 31st Annual Meeting

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    Event date： 2010.11

    Language：English  

    Venue：米国  

    国際学会

  • Koyama J., Takenouchi A., Nigaya,S., Murakami M, Kokushi E. and Uno S.   Bioaccumulation of organotins by fish and rock shell and their effects   International conference

    First International Conference on Managing Ecosystem Health of Tropical Seas: Environmental Management in Coastal Ecosystems  First International Conference on Managing Ecosystem Health of Tropical Seas: Environmental Management in Coastal Ecosystems

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    Event date： 2010.10

    Language：English  

    Venue：マレーシア  

    国際学会

  • Emiko Kokushi, Seiichi Uno, Jiro Koyama   Assessment of Effects of Starvation on Freshwater Carp by 1H-NMR Metabolomics Approach.   International conference

    The 39th Scientific Symposium of UJNR Aquaculture Panel Meeting  The 39th Scientific Symposium of UJNR Aquaculture Panel Meeting

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    Event date： 2010.10

    Language：English  

    Venue：鹿児島  

    国際学会

  • 志賀慧、高木光博、宇野誠一、國師恵美子、蓮沼浩、 松本大策、岡本光司、出口栄三郎   牛尿中ゼアラレノン濃度を指標とした給与飼料中ゼアラレノン浸潤動態モニター法の確率  

    日本産業動物獣医学会  日本産業動物獣医学会

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    Event date： 2010.10

    Language：Japanese  

    Venue：福岡  

    国内学会

  • 宇野 誠一、E.T.Bacolod、小山 次朗、田中博之   海産魚によるニトロアレーンの生物濃縮  

    第16回バイオアッセイ研究会・日本環境毒性学会合同研究発表会  第16回バイオアッセイ研究会・日本環境毒性学会合同研究発表会

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    Event date： 2010.9

    Language：Japanese  

    Venue：茨城  

    国内学会

  • 宇野 誠一、國師 恵美子、山元優孝、新豊葵、小山 次朗   メダカ稚魚を用いたメタボロミクスによる化学物質影響評価の試み  

    第16回バイオアッセイ研究会・日本環境毒性学会合同研究発表会  第16回バイオアッセイ研究会・日本環境毒性学会合同研究発表会

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    Event date： 2010.9

    Language：Japanese  

    Venue：茨城  

    国内学会

  • 山元優孝、宇野 誠一、小山 次朗   メタボロミクスによる多環芳香族炭化水素のメダカ胚に対する影響評価  

    第16回バイオアッセイ研究会・日本環境毒性学会合同研究発表会  第16回バイオアッセイ研究会・日本環境毒性学会合同研究発表会

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    Event date： 2010.9

    Language：Japanese  

    Venue：茨城  

    国内学会

  • 新野 竜大, 宇野 誠一, 國師 恵美子, 山元 優孝, 小安 純子, 大堀 祐司, 斎藤 穂高   魚胚に対するエコトキシコメタボロミクスの医薬品環境影響評価への応用  

    第37回日本トキシコロジー学会学術年会  第37回日本トキシコロジー学会学術年会

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    Event date： 2010.6

    Language：Japanese  

    Venue：沖縄  

    国内学会

  • S. Uno, H. Tanaka, E. Kokushi, K. Ito, M. Yamamoto, J. Koyama   Monitoring OF NITROARENES IN BIVALVES FROM OSAKA BAY, JAPAN   International conference

    6th International Conference on Marine Pollution and Ecotoxicology  6th International Conference on Marine Pollution and Ecotoxicology

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    Event date： 2010.6

    Language：English  

    Venue：香港  

    国際学会

  • S. Uno, H. Tanaka, E. Kokushi, K. Ito, M. Yamamoto, J. Koyama   Monitoring of nitroarenes in bivalves from Osaka Bay, Japan   International conference

    6th International Conference on Marine Pollution and Ecotoxicology  6th International Conference on Marine Pollution and Ecotoxicology

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    Event date： 2010.6

    Language：English  

    Venue：香港  

    国際学会

  • 伊藤一輝, 宇野誠一, 田中博之, 國師恵美子, 山元優孝, 三木志津帆, 小山次朗   大阪湾沿岸域における二枚貝中のアルキル化多環芳香族炭化水素類及び多環芳香族炭化水素類のモニタリング  

    第19回環境化学討論会  第19回環境化学討論会

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    Event date： 2010.6

    Language：Japanese  

    Venue：愛知  

    国内学会

  • 宇野誠一、國師恵美子、 小山次朗   フィリピンギマラス島における石油流出事故の石油汚染モニタリング－II  

    第19回環境化学討論会  第19回環境化学討論会

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    Event date： 2010.6

    Language：Japanese  

    Venue：愛知  

    国内学会

  • 國師恵美子、宇野誠一、小山次朗   メタボロミクスによるヒメダカに対する多環芳香族炭化水素類の影響評価  

    第19回環境化学討論会  第19回環境化学討論会

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    Event date： 2010.6

    Language：Japanese  

    Venue：愛知  

    国内学会

  • Emiko Kokushi, Seiichi Uno, Jiro Koyama   Assessment of Metabolite Variations in Starved Freshwater Carp by 1H-NMR Metabolomics Approach   International conference

    TH INTERNATIONAL CONFERENCE ON MARINE POLLUTION AND ECOTOXICOLOGY  TH INTERNATIONAL CONFERENCE ON MARINE POLLUTION AND ECOTOXICOLOGY

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    Event date： 2010.6

    Language：English  

    Venue：香港  

    国際学会

  • 志賀慧、髙木光博、宇野誠一、蓮沼浩、岡本光司、出口栄三郎   牛尿中ゼアラレノン濃度を指標とした給与飼料中ゼアラレノン浸潤動態モニター法の確立  

    平成２１年度日本獣医師会学会年次大会  平成２１年度日本獣医師会学会年次大会

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    Event date： 2010.1

    Language：Japanese  

    Venue：宮崎  

    国内学会

  • M. Yamamoto, J. Koyama, S. Uno   Toxicity assessment of PAHs on medaka embryo by 1H-NMR metabolomics approach   International conference

    International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia  International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia

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    Event date： 2009.10

    Language：English  

    Venue：鹿児島  

    国際学会

  • E. Kokushi, S. Uno, J. Koyaa   Assessment of Effects of Starvation on Freswater Carp by 1H-NMR Metabolomics Approach   International conference

    International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia  International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia

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    Event date： 2009.10

    Language：English  

    Venue：鹿児島  

    国際学会

  • K. Murata, S. Uno, J. Koyama, T. Yoshikawa and H. Maeda   Degradation of Heavy Oil for Bioremediation by Alkanivorax Strain a1.   International conference

    International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia  International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia

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    Event date： 2009.10

    Language：English  

    Venue：鹿児島  

    国際学会

  • K. Ito, J. Koyama and S. Uno .   Bioaccumulation of Dietary PAHs and Alkylated PAHs byMussel.   International conference

    International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia  International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia

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    Event date： 2009.10

    Language：English  

    Venue：鹿児島  

    国際学会

  • K. Anraku, et al., H. Monteclaro, G. F. Quinitio, S. Uno and J. Koyama   Disturbance in sensory modality by water quality.   International conference

    International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia  International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia

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    Event date： 2009.10

    Language：English  

    Venue：鹿児島  

    国際学会

  • T. Yoshikawa, R. B. Sadaba, J. Koyama, S. Uno and H. Maeda   Analysis of Microbial Communities in a Bunker OilBioremediation Setup at Taklong Island, Guimaras, Philippines   International conference

    International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia  International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia

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    Event date： 2009.10

    Language：English  

    Venue：鹿児島  

    国際学会

  • I. G. Pahila, H. S. Taberna Jr., L. T. Gamarcha, R. Sadaba Jr., J. Koyama and S. Uno   Assessment of Petroleum Hydrocarbon Two Years after the M/TSolar 1 Oil Spill in Southern Guimaras, Central Philippines   International conference

    International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia  International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia

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    Event date： 2009.10

    Language：English  

    Venue：鹿児島  

    国際学会

  • S. Uno, E. Kokushi, I. G. Pahila, H. S. Taberna Jr., J. Koyam   Changings of Polycyclic Aromatic Hydrocarbons in AquaticOrganisms and Sediment at Guimaras after Oil Spill.   International conference

    International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia  International Symposium on the Formation of Research Centre on Control Against Negative Impacts to Coastal Fisheries Resources in Southeast Asia

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    Event date： 2009.10

    Language：English  

    Venue：鹿児島  

    国際学会

  • 小山次朗 土寄大地 宇野誠一   海産ヨコエビによる生態毒性試験  

    第15回日本環境毒性学会・バイオアッセイ研究会合同研究発表会  第15回日本環境毒性学会・バイオアッセイ研究会合同研究発表会

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    Event date： 2009.10

    Language：Japanese  

    Venue：東京  

    国内学会

  • 宋準榮 仲山慶 村上安則 北村真一、宇野誠一 小山次朗   重油暴露が魚類ウイルス性疾病の発生に与える影響  

    第15回日本環境毒性学会・バイオアッセイ研究会合同研究発表会  第15回日本環境毒性学会・バイオアッセイ研究会合同研究発表会

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    Event date： 2009.10

    Language：Japanese  

    Venue：東京  

    国内学会

  • Nathaniel C. Anasco, Jiro Koyama, Seiichi Uno, Naoya Kuwahara   BIOACCUMULATION OF PESTICIDES BY COASTAL BIVALVES Barbatia virescens, Saccostrea mordax and Mytilus galloprovincialis   International conference

    14th INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT  14th INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT

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    Event date： 2009.9

    Language：English  

    Venue：フランス  

    国際学会

  • Koyama J., Takenouchi A., Nigaya S. Kokushi E. and Uno S.   BIOACCUMULATION OF ORGANOTINS AND IMPOSEX INDUCTION IN ROCK SHELL THAIS CLAVIGERA   International conference

    14th INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT  14th INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT

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    Event date： 2009.9

    Language：English  

    Venue：フランス  

    国際学会

  • 木藤麻美・宇野誠一・小山次朗，田中博之   大阪湾底泥中エストロゲン様物質の分布とそのエストロゲン活性に関する研究  

    第11回環境ホルモン学会研究発表会  第11回環境ホルモン学会研究発表会

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    Event date： 2008.12

    Language：Japanese  

    Venue：東京  

    国内学会

  • Nathaniel Anasco, Jiro Koyama and Seiichi Uno   CONCENTRATIONS OF PESTICIDES IN TRANSPLANTED AND NATIVE MARINE BIVALVES FROM A COASTAL AREA AFFECTED BY RICE PADDY EFFLUENT IN SOUTHERN JAPAN   International conference

    第5回世界水産学会  第5回世界水産学会

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    Event date： 2008.10

    Language：English  

    Venue：神奈川  

    国際学会

  • 宇野 誠一、國師 恵美子、小山 次朗   流出油および油処理剤の水産生物に対する影響  

    平成20 年度日本水産学会九州支部大会セミナー  平成20 年度日本水産学会九州支部大会セミナー

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    Event date： 2008.9

    Language：Japanese  

    Venue：長崎  

    国内学会

  • 田中博之，宇野誠一，三木志津帆，河野久美子，市橋秀樹，小山次朗   大阪湾におけるニトロアレーンの挙動  

    第17回環境化学討論会  第17回環境化学討論会

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    Event date： 2008.6

    Language：Japanese  

    Venue：兵庫  

    国内学会

  • 田中博之、宇野誠一、三木志津帆、河野久美子、市橋秀樹、小山次朗   大阪湾におけるニトロアレーンの挙動   International conference

    第17回環境化学討論会  第17回環境化学討論会

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    Event date： 2008.6

    Language：English  

    Venue：兵庫  

    国際学会

  • Nathaniel C. Anasco, Jiro Koyama, Seiichi Uno   Occurrence and Spatio-Temporal Distribution of Pesticide Residues in Coastal Waters Affected by Rice Paddy Effluents in Southern Japan  

    第17回環境化学討論会  第17回環境化学討論会

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    Event date： 2008.6

    Language：Japanese  

    Venue：兵庫  

    国内学会

  • 宇野誠一、田中博之、小山次朗、三木志津帆   大阪湾底質におけるニトロアレーンの分布  

    第17回環境化学討論会  第17回環境化学討論会

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    Event date： 2008.6

    Language：Japanese  

    Venue：兵庫  

    国内学会

  • 國師恵美子、宇野誠一、小山次朗   1H-NMRメタボロミクス法を用いた殺虫剤BPMCの魚類に対する有害性評価に関する研究  

    第17回環境化学討論会  第17回環境化学討論会

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    Event date： 2008.6

    Language：Japanese  

    Venue：兵庫  

    国内学会

  • S. Uno, E. Kokushi, J. Koyama   Toxicological Effects of Heavy Oil on Carp by NMR-based Metabolic Profiling of Plasma   International conference

    International Symposium on Biological Responses to Chemical Pollutants: Toward Establishing an Asian Network of Environmental Toxicology  International Symposium on Biological Responses to Chemical Pollutants: Toward Establishing an Asian Network of Environmental Toxicology

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    Event date： 2008.3

    Language：English  

    Venue：愛媛  

    国際学会

  • 國師恵美子、宇野誠一、小山次朗   淡水魚の尿を用いたメタボロミクスによる環境汚染物質の有害性評価  

    第14回バイオアッセイ研究会・日本環境毒性学会合同研究発表会  第14回バイオアッセイ研究会・日本環境毒性学会合同研究発表会

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    Event date： 2008.1

    Language：Japanese  

    Venue：茨城  

    国内学会

  • Emiko. Kokushi, Seiichi. Uno, Jiro Koyama   Metabolomics Approach on the Effects of Heavy Oil to Cyprinus carpio using 1H-NMR spectroscopy   International conference

    Seminar on the management of inshore environment and utilization of fisheries resources  Seminar on the management of inshore environment and utilization of fisheries resources

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    Event date： 2007.11

    Language：English  

    Venue：鹿児島  

    国際学会

  • Jiro Koyama, Seiichi Uno, Emiko Kokushi, Shizuho Miki and Ida Pahila   Monitoring of oil spill impacts on coastal environment of Guimaras from September 2006 to March 2007   International conference

    拠点大学交流事業セミナー  拠点大学交流事業セミナー

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    Event date： 2007.11

    Language：English  

    Venue：鹿児島  

    国際学会

  • Emiko KOKUSHI, Seiichi UNO, Jiro KOYAMA   Metabolomics Approach on the Effects of Heavy Oil to Cyprinus capio using 1H-NMR spectroscopy   International conference

    拠点大学交流事業セミナー  拠点大学交流事業セミナー

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    Event date： 2007.11

    Language：English  

    Venue：鹿児島  

    国際学会

  • Shizuho Miki, Seiichi Uno, Hiroyuki Tanaka and Jiro Koyama   Distribution of polycyclic aromatic hydrocarbons and alkylated polycyclic aromatic hydrocarbons in the sediments of Osaka Bay   International conference

    拠点大学交流事業セミナー  拠点大学交流事業セミナー

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    Event date： 2007.11

    Language：English  

    Venue：鹿児島  

    国際学会

  • Nathaniel Anasco, Jiro Koyama, Seiichi Uno and Naoya Kuwahara   CONCENTRATIONS OF PESTICIDES IN TRANSPLANTED AND NATIVE MARINE BIVALVES FROM A COASTAL AREA AFFECTED BY RICE PADDY-WASTEWATER RESERVOIR RUNOFFS   International conference

    拠点大学交流事業セミナー  拠点大学交流事業セミナー

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    Event date： 2007.11

    Language：English  

    Venue：鹿児島  

    国際学会

  • J. O. Cheikyula, J. Koyama and S. Uno   Comparative Study of Bioconcentration and EROD Activity Induction in the Japanese Flounder, Red Sea Bream, and Java Medaka Exposed to Water Borne Polycyclic Aromatic Hydrocarbons   International conference

    13th INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT  13th INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT

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    Event date： 2007.8

    Language：English  

    Venue：富山  

    国際学会

  • Shoko Imai, Jiro Koyama, Seiichi Uno and Kazunori Fujii   Effects of 17β-estradiol on sperm motility of Java medaka (Oryzias javanicus)   International conference

    13th INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT  13th INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT

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    Event date： 2007.8

    Language：English  

    Venue：富山  

    国際学会

  • 三木志津帆・宇野誠一・小山次朗・田中博之   大阪湾底泥中のアルキル化PAH及びPAH類の分布  

    第13回日本環境毒性学会・バイオアッセイ研究会合同研究発表会  第13回日本環境毒性学会・バイオアッセイ研究会合同研究発表会

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    Event date： 2007.7

    Language：Japanese  

    Venue：東京  

    国内学会

  • 宇野 誠一、國師 恵美子、ANASCO Nathaniel、Moteclaro Harold、Satander Sheryl   フィリピンギマラス島における石油流出事故の石油汚染モニタリング-I  

    第16回環境化学討論会  第16回環境化学討論会

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    Event date： 2007.6

    Language：Japanese  

    Venue：福岡  

    国内学会

  • 國師恵美子、宇野誠一、小山次朗   1H-NMRメタボロミクス法による魚類化学物質影響評価法の研究  

    第16回環境化学討論会  第16回環境化学討論会

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    Event date： 2007.6

    Language：Japanese  

    Venue：福岡  

    国内学会

  • 小山次朗・竹之内綾・國師恵美子・二茅早世子・宇野誠一   鹿児島湾有機スズ汚染と巻貝インポセックスの経年変化  

    平成19年度日本水産学会春季大会  平成19年度日本水産学会春季大会

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    Event date： 2007.3

    Language：Japanese  

    Venue：東京  

    国内学会

  • 宇野誠一・小山次朗・國師恵美子・三木志津帆・J.O. Cheikyula   フィリピンギマラス島重油流出事故の影響評価  

    平成19年度日本水産学会秋季大会  平成19年度日本水産学会秋季大会

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    Event date： 2007.1

    Language：Japanese  

    Venue：北海道  

    国内学会

  • 今井祥子, 金子容子, 宇野誠一, 小山次朗, 藤井一則   ジャワメダカ(Oryzias javanicus)に及ぼす17β-エストラジオールおよびエストロン混合暴露の影響  

    第9回環境ホルモン学会研究発表会  第9回環境ホルモン学会研究発表会

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    Event date： 2006.11

    Language：Japanese  

    Venue：東京  

    国内学会

  • 栗谷川俊之、高木光博、岡本光司、宇野誠一、大塚彰、出口栄三郎   飼養形態の違いが牛尿中ゼアラレノン濃度に与える影響  

    平成１８年度日本産業動物獣医学会  平成１８年度日本産業動物獣医学会

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    Event date： 2006.10

    Language：Japanese  

    Venue：熊本  

    国内学会

  • 國師恵美子・村上雅代・宇野誠一・小山次朗   スズキ及びマダイの有機スズ類蓄積性比較に関する研究  

    第12回バイオアッセイ研究会・日本環境毒性学会合同研究発表会  第12回バイオアッセイ研究会・日本環境毒性学会合同研究発表会

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    Event date： 2006.9

    Language：Japanese  

    Venue：東京  

    国内学会

  • J.Koyama, A.Kakuno, J.O.Cheikyula and S.Uno   Toxicity of heavy fuel oil, dispersant, and oil-dispersant mixtures to a marine fish, Pagrus major   International conference

    SETAC Asia-Pacific  SETAC Asia-Pacific

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    Event date： 2006.9

    Language：English  

    Venue：中国  

    国際学会

  • 三木志津帆、宇野誠一、小山次朗   高速溶媒抽出法を用いた底質中多環芳香族類及びアルキル化多環芳香族類の同時分析法の開発  

    第15回環境化学討論会  第15回環境化学討論会

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    Event date： 2006.6

    Language：Japanese  

    Venue：宮城  

    国内学会

  • 小山次朗・村上雅代・宇野誠一   スズキ及びマダイ免疫能に対する有機スズの影響  

    平成18年度日本水産学会  平成18年度日本水産学会

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    Event date： 2006.3

    Language：Japanese  

    Venue：高知  

    国内学会

  • 高垣勝仁、高木光博、岡本光司、宇野誠一、大塚彰、出口栄三郎   給与飼料の違いがウシ尿中ゼアラレノン濃度に与える影響  

    平成１７年度日本産業動物獣医学会  平成１７年度日本産業動物獣医学会

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    Event date： 2005.10

    Language：Japanese  

    Venue：鹿児島  

    国内学会

  • 磯部 友彦, 仲山 慶, 宇野 誠一, 大野 暢亮, 半藤 逸樹, 国末 達也   環境モニタリングデータのためのオープンデータプラットフォーム「ChemTHEATRE」  

    環境ホルモン学会研究発表会要旨集  2018.12  環境ホルモン学会(日本内分泌撹乱化学物質学会)

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Research Projects

  • 海洋流出マイクロプラスチックの物理・化学的特性に基づく汚染実態把握と 生物影響評価

    Grant number：1-2204  2022 - 2024

    環境再生保全機構  環境研究総合推進費 

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    Authorship：Coinvestigator(s) 

  • 飼養環境下の牛群における多種類カビ毒同時浸潤動態の解明とその防除法の検証

    Grant number：21K05920  2021.4 - 2024.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    高木 光博, 宇野 誠一, 大和 修

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    本申請課題の目的の１つである、尿中多種類カビ毒同時測定系の新規確立に関しては、これまでに確立しているゼアラレノン(ZEN)とステリグマトシスチン(STC)に加えて、デオキシニバレノールとフモニシンに関してはすでに測定系をほぼ確立しており、アフラトキシンB１に関してはその可否を検討中である。牛群におけるカビ毒浸潤動態が牛生体内代謝や繁殖性に与える影響に関する検証では、尿中ZEN濃度と牛卵巣内胞状卵胞数モニターのバイオマーカーである血中抗ミューラー管ホルモン(AMH)濃度との間に負の相関関係があることを明らかにするとともに、炎症性マーカーである血清アミロイドA（SAA）濃度測定とも負の相関を確認しており、現在試験頭数を増やしながら検証を継続している。さらに、新規カビ毒防除法確立の一環として継続している、飼料への「オリゴ糖製剤」や「熱処理乳酸菌死菌体製剤」の添加による、尿中カビ毒濃度低減効果の検証に関しては、様々な発育ステージにおける牛群において添加試験を継続中であり、これまでに給与飼料へのオリゴ糖製剤(DFAIII)添加による尿中STC濃度低減効果を初めて報告するとともに、現在はDFA III添加群と無添加群との間の血中低級脂肪酸濃度（腸管内におけるDFAIII発酵状況の確認）の比較検討を行なっている。さらに、黒毛和種哺乳期子牛を用いた代用乳への熱処理乳酸菌死菌体製剤添加試験を実施し、すでに予定していた全サンプリングと各種測定を終了済みで、現在は得られた全データの解析を進行中である。

  • マレーシア沿岸・河口域底質汚染の毒性リスクと生物多様性へのインパクトの包括的評価

    Grant number：19KK0275  2019.10 - 2023.3

    日本学術振興会  科学研究費助成事業 国際共同研究加速基金(国際共同研究強化(B))  国際共同研究加速基金(国際共同研究強化(B))

    宇野 誠一, 仲山 慶, 國師 恵美子

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    Grant amount：\18460000 （ Direct Cost: \14200000 、 Indirect Cost：\4260000 ）

    本研究はマレーシアにおいて、底質毒性評価を行うことを第1の目的とする。マレーシア西部は下水処理場が発達するが、東側は全くといって良いほど設置されてない。そのため、沿岸域底質においても東側の方が汚染が深刻で、底生生物やその生物多様性に及ぼす影響は大きいと予想される。本研究ではマレーシアでの調査を通し、マレーシア底質影響レベルの現状を明らかにすると共に、下水処理場の効果を明らかにするものである。
    令和2年度は新型コロナの影響により、マレーシアに渡航できなかった。そのため、予定していたマレーシアでの調査や、共同研究者のいるマレーシア トレンガヌ大学での交流は全くできなかった。また、マレーシアでも厳格な検疫体制が取られており、マレーシア人ですら国内を自由に移動することが厳しく制限されているため、共同研究者の野外における調査も全くできなかった。そのため、2年度に予定してた調査・研究は全く予定通りに進まなかった。共同研究者とはメールなどで連絡を取っているが、マレーシアは日本よりも厳格な体制でコロナに臨んでおり、現状でこの研究が前に進められる要素は少ない。そのため、できることは限られたが2年度は日本の底質における環境DNA適用の可能性の探索、そして、日本におけるジャワメダカ胚を用いた底質毒性調査を重ねながら、その手法の発展を図った。また、網羅的な化学物質分析の検証と適用法の具体的な検討を行った。他、化学物質測定に関しては底質から検出される可能性があり、何らかの形で野外でも生物に影響を与える可能性があるものをピックアップし、個々の分析法の最適化を進めている。これらの方法は、マレーシアに渡航できて、サンプリングが可能になったときに適用する予定である。

  • Clinical validation and metabolic endocrinological evaluation of novel mycotoxins control methods in herds

    Grant number：18K05971  2018.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Takagi Mitsuhiro

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    At livestock farms, measures to control mycotoxins that contaminate the feed fed to livestock are a global challenge. In this study, based on the results of the measurement system of both zearalenone (ZEN) and sterigmatocystin (STC) in bovine urine, it was revealed that 1) supplementation of oligosaccharide preparations to cattle feed reduces the absorption of ZEN and STC from the intestinal tract, 2) from the urinary metabolome analysis, the in vivo ATP production and amino acid metabolism in the highly exposed cattle group of both ZEN and STC are significantly changed as compared with the low exposed group, 3) it was found that the in vitro anti-inflammatory effect of bovine oviductal epithelial cells on sperm is inhibited after the ZEN exposure, and 4) blood anti-Mullerian hormone concentration measurement is useful as an endocrine index for monitoring the fertility of cows.

  • Evaluation of toxicities and risk distributions in sediment collected in inner bay closed big cities; using sea water fish, Java medaka

    Grant number：18K11667  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Uno Seiichi

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    The risk distributions in sediments collected in Tokyo, Osaka, Ise, and Hakata Bays were investigated with Java medaka embryos. In Tokyo Bay, high mortality was observed in embryos exposed to sediments collected near Chiba city, Chiba prefecture. In Ise Bay, several effects were observed in embryos exposed sediments collected around the international airport. We think that their sediments might have a certain effect to the aquatic organisms lived around there. In Osaka Bay, Yodo river possibly have some influence to organisms, and sediments in the estuary showed high risks. Sediments with a certain risk were widely distributed in Hakata and Dokai Bays, and shows most serious toxicities. The risks were suspected the serious effects in the aquatic organisms.