Life Science / Virology

Yoshihara T, Takiguchi S, Kyuno A, Tanaka K, Kuba S, Hashiguchi S, Ito Y, Hashimoto T, Iwatsubo T, Tsuyama S, Nakashima T, Sugimura K. .  Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro. .  J. Biochem.143 ( 4 ) 475 - 486   2008.4Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro.Reviewed

Ken Sasaki, Jyoti Gaikwad, Shuhei Hashiguchi, Toshiya Kubota, Kazuhisa Sugimura, Werner Kremer, Hans Robert Kalbitzer, and Kazuyuki Akasaka .  Reversible monomer-oligomer transition in human prion protein. .  PRION2 ( 3 ) 118 - 122   2008.1Reversible monomer-oligomer transition in human prion protein.Reviewed

T. Hamasaki, S. Uchida, T. Yoshihara, S. Hashiguchi, Y. Ito, K. Sugimura .  Biopanning of antibody-phage clones using immunoplates coated with gel slices of electrophoresis, immunogel-biopanning. .  Biol. Pharm. Bull30 ( 8 ) 1361 - 1364   2007.8Biopanning of antibody-phage clones using immunoplates coated with gel slices of electrophoresis, immunogel-biopanning.Reviewed

T. Hamasaki, S. Hashiguchi, Y. Ito, Z. Kato*, K. Nakanish*, T. Nakashima*, K. Sugimura .  Human Anti-Human IL-18 Antibody Recognizing the IL-18-Binding Site 3 with IL-18 Signaling Blocking Activity .  J.Biochem138 ( 4 ) 433 - 442   2005.10Human Anti-Human IL-18 Antibody Recognizing the IL-18-Binding Site 3 with IL-18 Signaling Blocking ActivityReviewed

R. Matsumoto, K. Fujino*, Y. Nagata, S. Hashiguchi, Y. Ito, Y. Aihara*, Y. Takahashi*,K. Maeda*, K. Sugimura .  Molecular characterization of a 10-kDa buckwheat molecule reactive to allergic patients' IgE .  Allergy59 ( 5 ) 533 - 538   2004.5Molecular characterization of a 10-kDa buckwheat molecule reactive to allergic patients' IgEReviewed

Hashiguchi S, Nakashima T, Nitani A, et al .  Human Fc epsilon RIalpha-specific human single-chain Fv (scFv) antibody with antagonistic activity toward IgE/Fc epsilon RIalpha-binding .  J. Biochem.133 ( 1 ) 43 - 49   2003Human Fc epsilon RIalpha-specific human single-chain Fv (scFv) antibody with antagonistic activity toward IgE/Fc epsilon RIalpha-bindingReviewed

Gejima R, Tanaka K, et al .  Human single-chain Fv (scFv) antibody to human IL-6 with the inhibitory activity on IL-6-signaling .  Hum. Antibodies11 ( 4 ) 121 - 129   2002Human single-chain Fv (scFv) antibody to human IL-6 with the inhibitory activity on IL-6-signalingReviewed

Kaji M, Ikari M, Hashiguchi S, et al .  Peptide mimics of monocyte chemoattractant protein-1 (MCP-1) with an antagonistic activity .  J. Biochem.129 ( 4 ) 577 - 583   2001Peptide mimics of monocyte chemoattractant protein-1 (MCP-1) with an antagonistic activityReviewed

杉村和久ほか .  HIV-1: エントリーインヒビターとスキン免疫 .  日本臨床免疫学会誌23 ( 6 ) 592 - 596   2000HIV-1: エントリーインヒビターとスキン免疫

Hirai T, Hashiguchi S, et al .  Intranasal sensitization of Japanese cedar pollen by the co-administration of low doses of cholera toxin but not its recombinant B subunit to mice .  Microbiol. Immunol.44 ( 4 ) 259 - 266   2000Intranasal sensitization of Japanese cedar pollen by the co-administration of low doses of cholera toxin but not its recombinant B subunit to miceReviewed

Nagata Y, Fujino K, Hashiguchi S, et al .  Molecular characterization of buckwheat major immunoglobulin E-reactive protein in allergic patients .  Allergol. Int.49 ( 2 ) 117 - 124   2000Molecular characterization of buckwheat major immunoglobulin E-reactive protein in allergic patientsReviewed

Hashiguchi S, Hino K, Taniguchi Y, et al .  Determination of seven regions of a major allergen, Cry j 2, of Japanese cedar pollen for T-cell immunity .  Allergy51 ( 9 ) 621 - 632   1996Determination of seven regions of a major allergen, Cry j 2, of Japanese cedar pollen for T-cell immunityReviewed

Sugimura K, Hashiguchi S, Takahashi Y, et al .  Th1/Th2 responses profiles to the major allergens Cry j 1 and Cry j 2 of Japanese cedar pollen .  Allergy51 ( 10 ) 732 - 740   1996Th1/Th2 responses profiles to the major allergens Cry j 1 and Cry j 2 of Japanese cedar pollenReviewed

橋口 周平 .  第1土曜特集 ワクチン設計のサイエンス 各論 【Phage vector】 細菌に感染するバクテリオファージを担体とするファージワクチン設計 .  医学のあゆみ279 ( 10 ) 1047 - 1052   2021.12第1土曜特集 ワクチン設計のサイエンス 各論 【Phage vector】 細菌に感染するバクテリオファージを担体とするファージワクチン設計

Devanthéry T. .  Structure of a heptose-containing polysaccharide derived from Komagataeibacter europaeus NBRC 3261 .  Carbohydrate Research492   107989   2020.6

Hashimoto Masahito, Matsumoto Taichi, Tamura-Nakano Miwa, Ozono Mami, Hashiguchi Shuhei, Suda Yasuo .  Acetobacter pasteurianus NBRC3283の外膜小胞の特徴の解析(Characterization of outer membrane vesicles of Acetobacter pasteurianus NBRC3283) .  Journal of Bioscience and Bioengineering125 ( 4 ) 425 - 431   2018.4Acetobacter pasteurianus NBRC3283の外膜小胞の特徴の解析(Characterization of outer membrane vesicles of Acetobacter pasteurianus NBRC3283)

Waki Junpei, Nakayama-Imaohji Haruyuki, Ozono Mami, Hashiguchi Shuhei, Kuwahara Tomomi, Hashimoto Masahito .  TLR2 activating substance in the capsular polysaccharide fraction of <i>Bacteroides fragilis</i> .  Endotoxin and Innate Immunity21 ( 0 ) 18 - 22   2018

Masahito Hashimoto, Junpei Waki, Haruyuki Nakayama-Imaohji, Mami Ozono, Shuhei Hashiguchi, Tomomi Kuwahara .  TLR2-stimulating contaminants in glycoconjugate fractions prepared from Bacteroides fragilis .  INNATE IMMUNITY23 ( 5 ) 449 - 458   2017.5Reviewed

Masahito Hashimoto, Mami Ozono, Maiko Furuyashiki, Risako Baba, Shuhei Hashiguchi, Yasuo Suda, Koichi Fukase, Yukari Fujimoto .  Characterization of a novel D-glycero-D-talo-oct-2-ulosonic acid-substituted lipid a moiety in the lipopolysaccharide produced by the acetic acid bacterium Acetobacter pasteurianus NBRC 3283 .  Journal of Biological Chemistry291   21184 - 21194   2016.9Characterization of a novel D-glycero-D-talo-oct-2-ulosonic acid-substituted lipid a moiety in the lipopolysaccharide produced by the acetic acid bacterium Acetobacter pasteurianus NBRC 3283Reviewed

Gondaira S, Higuchi H, Iwano H, Nakajima K, Kawai K, Hashiguchi S, Konnai S, Nagahata H. .  Cytokine mRNA profiling and the proliferative response of bovine peripheral blood mononuclear cells to Mycoplasma bovis. .  Veterinary Immunology and Immunopathology165   45 - 53   2015.5Cytokine mRNA profiling and the proliferative response of bovine peripheral blood mononuclear cells to Mycoplasma bovis.Reviewed

Ryohei Shioya, Ryuji Miyahara, Yoshitsugu Shoji, Kazuhisa Sugimura, Shuhei Hashiguchi .  Development of universal phage vaccine displaying extracellular domains of M2e derived from human influenza A viruses. .  Peptide Science 2014   265 - 266   2014.3Development of universal phage vaccine displaying extracellular domains of M2e derived from human influenza A viruses.Reviewed

Tsurumaru T, Oda R, Osako T, Uehara K, Gotanda T, Hashiguchi S, Sugimura K. .  Influenza virus vaccine using phage display technology. .  Peptide Science 2012   263 - 264   2013.3Influenza virus vaccine using phage display technology.Reviewed

Kawabata S, Osako T, Abe R, Hashiguchi S, Nakagawa S, Sugimura K. .  B6-C15 peptide motif as a probe for immunotherapy and biomarker for Alzheimer's Disease. .  Peptide Science 2012   241 - 244   2013.3B6-C15 peptide motif as a probe for immunotherapy and biomarker for Alzheimer's Disease.Reviewed

Osako T, Kawabata S, Tsurumaru T, Uehara K, Hashiguchi S, Sugimura K. .  Phage vaccine displaying an epitope peptide for immunotherapy of Alzheimer's Disease. .  Peptide Science 2012   237 - 240   2013.3Phage vaccine displaying an epitope peptide for immunotherapy of Alzheimer's Disease.Reviewed

Tomari D, Shioya R, Hashiguchi S, Sugimura K. .  Desensitization effecrts of cedar pollinosis by pre administration of allergic epitope displaying M13 phage. .  Peptide Science 2012   265 - 268   2013.3Desensitization effecrts of cedar pollinosis by pre administration of allergic epitope displaying M13 phage.Reviewed

Kai S, Hashiguchi S, Sugimura K .  Desensitization vaccine strategy using M13 phage whose g8p display a B cell IgG epitope of Cry j 1 as a major allergen of Japanse cedar pollen .  Peptide Science 2011   269 - 270   2012.3Desensitization vaccine strategy using M13 phage whose g8p display a B cell IgG epitope of Cry j 1 as a major allergen of Japanse cedar pollenReviewed

Yang J-P, et al .  Mimotope analysis of human single chain antibodies corss-reacted to both H1 (H1N1) and H5 (H5N1) subtype influenza viruses .  Peptide Science 2010   2011.3Mimotope analysis of human single chain antibodies corss-reacted to both H1 (H1N1) and H5 (H5N1) subtype influenza virusesReviewed

Hashiguchi S, Yamaguchi Y, Tahara H, et al .  Immunological basis of M13 phage vaccines: an effective vaccine design tested in a mouse model of Alzheimer's disease .  Peptide Science 2010   2011.3Immunological basis of M13 phage vaccines: an effective vaccine design tested in a mouse model of Alzheimer's diseaseReviewed

Satomi K, Yamada T, et al .  Preparation of M13 phage displaying g8p coat protein fused with a conformational mimotope of amyloind-beta 42 fibril .  Peptide Science 2010   2011.3Preparation of M13 phage displaying g8p coat protein fused with a conformational mimotope of amyloind-beta 42 fibrilReviewed

Tanaka K, Abe R, Yamaguchi Y, et al .  Mimotope peptide of amyloid-beta42 fibril-specific antibodies bind to amyloid plaques in brain sections of Alzheimer's disease model mouse, J20 .  Peptide Science 2010   2011.3Mimotope peptide of amyloid-beta42 fibril-specific antibodies bind to amyloid plaques in brain sections of Alzheimer's disease model mouse, J20Reviewed

Asada T, Muraoka S, Hashiguchi S, Ijichi S, Sugimura K .  Characterization of human antibody light chain-displaying phage library .  Peptide Science 2009   465 - 466   2010.3Characterization of human antibody light chain-displaying phage libraryReviewed

Kariya Y, et al .  Analysis of sugar-binding peptide motifs of influenza H5 hemagglutinin using phage-display library .  Peptide Science 2009   53 - 54   2010.3Analysis of sugar-binding peptide motifs of influenza H5 hemagglutinin using phage-display libraryReviewed

Hatanaka T, et al .  Affinity purification of IgG by specific peptide-conjugated column .  Peptide Science 2009   259 - 260   2010.3Affinity purification of IgG by specific peptide-conjugated columnReviewed

Tanaka K, et al .  Amyloid beta42 fibril mimotope-peptides bind to deposited amyloid beta in brain section of Alzheimer's disease model mouse, J20 .  Peptide Science 2009   293 - 296   2010.3Amyloid beta42 fibril mimotope-peptides bind to deposited amyloid beta in brain section of Alzheimer's disease model mouse, J20Reviewed

Kamino T, et al .  Phage-library displaying toll-like receptor as leucine-rich repeat (LRR) protein scaffold .  Peptide Science 2009   309 - 310   2010.3Phage-library displaying toll-like receptor as leucine-rich repeat (LRR) protein scaffoldReviewed

Yang J-P, et al .  Mimotope analysis of human single chain antibodies inhibiting the binding of influenza H5 to MDCK cells .  Peptide Science 2009   377 - 380   2010.3Mimotope analysis of human single chain antibodies inhibiting the binding of influenza H5 to MDCK cellsReviewed

Maeda M, Ito Y, Hatanaka T, et al .  Regulation of T cell response by blocking the ICOS signal with the B7RP-1-specific small antibody fragment isolated from human antibody phage library .  MAbs1 ( 5 ) 453 - 461   2009.8Regulation of T cell response by blocking the ICOS signal with the B7RP-1-specific small antibody fragment isolated from human antibody phage libraryReviewed

Satoshi Muraoka, Yuji Ito, Masaki Kamimura, Masanori Baba, Naomichi Arima, Yasuo Suda, Shuhei Hashiguchi, Masaharu Torikai, Toshihiro Nakashima, Kazuhisa Sugimura .  Effective Induction of Cell Death on Adult T-Cell Leukaemia Cells by HLA-DRb-Specific Small Antibody Fragment Isolated from Human Antibody Phage Library. .  J Biochem145 ( 6 ) 799 - 810   2009.6Effective Induction of Cell Death on Adult T-Cell Leukaemia Cells by HLA-DRb-Specific Small Antibody Fragment Isolated from Human Antibody Phage Library.Reviewed

Hatanaka T, Ito Y, Soni P, et al .  Effective elimination of a particular conformation of human IgG from antibody solution by a peptide affinity column .  Peptide Science 2008   477 - 478   2009.3Effective elimination of a particular conformation of human IgG from antibody solution by a peptide affinity columnReviewed

Tanaka K, Nishimura M, Takiguchi S, et al. .  Amyloid beta42 fibril mimic peptides inhibit the amyloid beta42 fibrillation by binding to prefibriller soluble oligomers .  Peptide Science 2008   67 - 70   2009.3Amyloid beta42 fibril mimic peptides inhibit the amyloid beta42 fibrillation by binding to prefibriller soluble oligomersReviewed

K. Tanaka, T. Yoshihara, S. Hashiguchi, Y. Ito, K. Sugimura .  Specific binding of A beta 42 mimic peptides to prefibrillar soluble oligomer resulting in inhibition of A beta 42-fibrillation .  International Psychogeriatrics, Cambridge University Press19 ( S1 ) 316   2007.10Specific binding of A beta 42 mimic peptides to prefibrillar soluble oligomer resulting in inhibition of A beta 42-fibrillationReviewed

S. Takiguchi, T. Yoshihara, K. Tanaka, A. Kyuno, S. Kuba, S. Hashiguchi, T. Nakashima, Y. Ito, K. Sugimura .  Snapshots of amyloid beta 1-42 conformers by human antibody-displaying phage library .  International Psychogeriatrics, Cambridge University Press19 ( S1 ) 418   2007.10Snapshots of amyloid beta 1-42 conformers by human antibody-displaying phage libraryReviewed

T. Yoshihara, S. Takiguchi, S. Kuba, M. Kimata, S. Hashiguchi, Y. Ito, T. Nakashima, K. Sugimura .  Snapshots of amyloid beta 1-42 conformers by human antibody-displaying phage library .  Neurodegenerative Dis4 ( S1 ) 189   2007.4Snapshots of amyloid beta 1-42 conformers by human antibody-displaying phage libraryReviewed

S. Muraoka, K. Sakamoto, S. Hashiguchi, Y. Ito, K. Sugimura .  Construction of T7 phage displaying fluorescence protein and its application for immuno detection .  Peptide Science 2005   473 - 474   2006.3Construction of T7 phage displaying fluorescence protein and its application for immuno detectionReviewed

K. Sakamoto, Y. Ito, S. Hashiguchi, T. Mori*, K. Sugimura .  HUMAN IMMUNOGLOBULIN G-SPECIFIC MOTIFS BY SCREENING OF A RANDOM PEPTIDE T7-PHAGE LIBRARY .  Peptide Science 2005   473 - 474   2006.3HUMAN IMMUNOGLOBULIN G-SPECIFIC MOTIFS BY SCREENING OF A RANDOM PEPTIDE T7-PHAGE LIBRARYReviewed

S. Hashiguchi, M. Yamamoto, S. Kitamoto, T. Nakashima*, H. Yamanaka*, D. Ishibashi*, S. Sakaguchi*, S. Katamine*, Y. Ito, K. Sugimura .  Prion-conformation-specific human antibodies established from phage display library .  PRIONS: Food and Drug Safety, (T. Kitamoto Ed.), pp.191-192, Springer   2005.4Prion-conformation-specific human antibodies established from phage display libraryReviewed

K. Sakamoto, Y. Ito, S. Muraoka,H. Waki, S. Hashiguchi, K. Sugimura .  Isolation of lactoferrin binding peptide by T7-phage display and its immunoregulatory activities .  Peptide Science 2004   357 - 358   2005.3Isolation of lactoferrin binding peptide by T7-phage display and its immunoregulatory activitiesReviewed

S. Hashiguchi, T. Hayashi, Y. Ito,K. Sugimura .  Binding Epitope of Human Anti-FcεRI α-chain Receptor Antibody, RE51, with the Blocking Activity on IgE-mediated Histamine Release .  Immunology2004   541 - 544   2004.10Binding Epitope of Human Anti-FcεRI α-chain Receptor Antibody, RE51, with the Blocking Activity on IgE-mediated Histamine ReleaseReviewed

Y. Ito, S. Yamashita, A. Tomichi,M. Maeda, S. Hashiguchi, K. Sakamoto, M. Torikai*,T. Nakashima*, K. Sugimura .  Blockade of costimulatory signals by anti B7RP-1 scFv antibodies from a human antibody phage library .  Immunology2004   467 - 470   2004.10Blockade of costimulatory signals by anti B7RP-1 scFv antibodies from a human antibody phage libraryReviewed

T. Hamasaki, S. Hashiguchi, Y. Ito, K. Nakanishi*, K. Sugimura .  Human antibody recognizing the epitope of Interleukin-18 Binding Site III for IL-18 receptor .  Immunology2004   481 - 484   2004.10Human antibody recognizing the epitope of Interleukin-18 Binding Site III for IL-18 receptorReviewed

Tanaka K, et al .  Affinity maturation of IL-6 mimic peptide IL-6/37 isolated from phage library .  Peptide Science 2003   347 - 350   2004.3Affinity maturation of IL-6 mimic peptide IL-6/37 isolated from phage libraryReviewed

Genetic engineering for immunotherapy for allergy .    133   43 - 49   2004.3Genetic engineering for immunotherapy for allergyReviewed

Ito Y, Gejima R, et al .  Structure-activity relationship of cytokine-mimic peptide from phage library .  Peptide Science 2001   113 - 116   2002.3Structure-activity relationship of cytokine-mimic peptide from phage libraryReviewed

Ikari M, Yamamoto M, et al .  Isolation of phage library clones selected by anti-IL-5 monoclonal antibody (TB-13) .  Peptide Science 1999   383 - 384   2000.3Isolation of phage library clones selected by anti-IL-5 monoclonal antibody (TB-13)Reviewed

Kaji M, Ikari M, Hashiguchi S, et al .  Analysis of peptide motifs recognized with anti-MCP-1 monoclonal antibody .  Peptide Science 1999   33 - 36   2000.3Analysis of peptide motifs recognized with anti-MCP-1 monoclonal antibodyReviewed

Ito Y, Takeda S, Mineyama J, Hashiguchi S, Sugimura K .  Ligand binding activity of the recombinant antigen fused with CTLA-4 mimicking motif .  Peptide Science 1999   379 - 382   2000.3Ligand binding activity of the recombinant antigen fused with CTLA-4 mimicking motifReviewed

Kajihara Y, Hashiguchi S, Ito Y, Sugimura K .  Th2-type immune response induced by a phage clone displaying a CTLA4-binding domain .  Gene Ther. Mol. Biol.5   29 - 36   2000Th2-type immune response induced by a phage clone displaying a CTLA4-binding domainReviewed

Ezaki K, Ito Y, Hashiguchi S, Sugimura K .  Effect of a CTLA4 mimicking motif fused to hen egg white lysozymes on the immune response .  Peptide Science 1998   325 - 328   1999.3Effect of a CTLA4 mimicking motif fused to hen egg white lysozymes on the immune responseReviewed

Hashiguchi S, Okuzono T, Ito Y, Sugimura K .  Peptide motif analysis of anti-TNF-alpha monoclonal antibodies using a phage display library .  Peptide Science 1998   385 - 386   1999.3Peptide motif analysis of anti-TNF-alpha monoclonal antibodies using a phage display libraryReviewed

Akasaki S, Hashiguchi S, Ito Y, Sugimura Y .  FACS analysis of the gene 3 protein derived from a phage library clone with T-cell proliferation-augmenting activity .  Peptide Science 1998   317 - 320   1999.3FACS analysis of the gene 3 protein derived from a phage library clone with T-cell proliferation-augmenting activityReviewed

Oomura Y, Ito Y, et al .  Affinity maturation of peptide motif mimicking CTLA4 binding domain .  Peptide Science 1998   321 - 324   1999.3Affinity maturation of peptide motif mimicking CTLA4 binding domainReviewed

Sugimura K, Fukumoto T, Torigoe N, Ito Y, Hashiguchi S .  Peptide mimics of the CTLA4-binding doamin stimulate T-cell proliferation .  The 10th International Congress of Immunology   373 - 378   1998Peptide mimics of the CTLA4-binding doamin stimulate T-cell proliferation

Hashiguchi S, Akasaki S, Ito Y, Sugimura K .  FACS analysis of the gene 3 protein derived from a phage library clone with T-cell proliferation-augmenting activity .  The 10th International Congress of Immunology   383 - 386   1998FACS analysis of the gene 3 protein derived from a phage library clone with T-cell proliferation-augmenting activity

Hashiguchi S, Hino K, Taniguchi Y, et al .  Determination of T cell epitope of a Japanese cedar pollen allergen, Cry j 2 .  Peptide Chemistry 1995   409 - 412   1996.3Determination of T cell epitope of a Japanese cedar pollen allergen, Cry j 2

抗体実験マニュアル―免疫染色、免疫沈降、フローサイトメトリー、タンパク質精製など抗体を用いた実験の原理とコツ、抗体医療の最新トピックス

旭由香里、伊東祐二、橋口周平、杉村和久（ Role： Joint author ,  ヒト抗体をディスプレイするバクテリオファージ：抗体ファージライブラリー）

羊土社  2008.5 

タンパク質研究のための抗体実験マニュアル

伊東祐二、橋口周平、杉村和久（ Role： Joint author ,  ヒト抗体をディスプレイするバクテリオファージ）

羊土社  2004.3 

低分子化抗体、ヒト抗体と小分子医薬品をつなぐ

橋口周平、杉村和久

細胞工学   26 ( 3 )   263 - 267   2007.2

ヒト化抗体作製の進歩

杉村和久、橋口周平、伊東祐二

Molecular Medicine   40 ( 10 )   1150 - 1158   2003.10

ヒト抗体エンジニアリングと分子標的医療

伊東祐二、田中孝一、橋口周平ほか

バイオインダストリー   20 ( 7 )   34 - 42   2003.7

皮膚に塗るDNAワクチン

橋口周平、杉村和久

臨床免疫   36 ( 6 )   949 - 952   2001.12

スギ花粉症の免疫療法に用いるペプチドアレルゲンの分子設計に関する基礎的研究

杉村和久、橋口周平、平井照正、鳥越直彦、杉町恵子、伊東祐二

臨床薬理の進歩   19   39 - 50   1998.6

Th1/Th2と抗原刺激様式

橋口周平、杉村和久

臨床免疫   29 ( 3 )   358 - 365   1997.3

スギ花粉抗原の分子生物学的解析とエピトープの同定

橋口周平、杉村和久

日本臨床   54 ( 8 )   2233 - 2242   1996.8

Narutoshi Tsukahara, Nozomi Kitade, Shuhei Yonamine, Shuhei Hashiguchi, Akikazu Murakami, Hidehiro Kishimoto   Development of rapid identification of vaccine candidate peptides by fusing two different phage display systems  

第47回日本免疫学会学術集会 

Waki J, Fukudome M, Hashiguchi S, Uchiumi T, Hashimoto M   Outer membrane vesicles production of Mesorhizobium loti and plant response   International conference

4th KU-NDSU Joint Symposium on Biotechnology, Nanomaterials and Polymers 

橋本雅仁、松元太一、中村佳祐、大薗まみ、橋口周平   酢酸菌由来外膜小胞の収量改善の検討  

第70回日本生物工学会大会  

中村 佳祐、松元 太一、橋口 周平、橋本 雅仁   酢酸菌外膜小胞回収の効率化の検討  

平成30年度日本生化学会九州支部例会 

橋本雅仁、松元太一、中村佳祐、馬場梨沙子、大薗まみ、橋口周平   Acetobacter pasteurianus 由来外膜小胞の分離と免疫刺激能  

2017年度生命科学系学会合同年次大会 

橋口周平、辻村誠一   Diurnal variations in humoral immune response against bacteriophage in mice  

日本時間生物学会学術大会 

辻村誠一、橋口周平   Development of a multi-primary illumination system for independent stimulation of photoreceptors in mice  

日本時間生物学会学術大会 

橋口周平、辻村誠一   メタマー光環境がマウスのアクティビティに与える影響に関する検討  

第160回日本獣医学会学術集会 

宮原隆二、篠崎太亮、中西美加、中川路けい、橋本雅仁、橋口周平、   抗原エピトープ特異的IgG抗体を誘導するファージワクチンの分子設計法  

第160回日本獣医学会学術集会 

橋本雅仁、松元太一、馬場梨沙子、大薗まみ、橋口周平   酢酸菌由来外膜小胞の産生と性質  

第69回日本生物工学会 

宮原隆二、樋口雄介、橋本雅仁、橋口周平   M13ファージペプチドワクチンの設計法：抗原提示方法の改良による抗原性の増強  

平成29年度日本生化学会九州支部例会 

中川路けい、宮原隆二、橋本雅仁、橋口周平   M13ファージを担体としたワクチンによる自己抗体誘導の可能性  

平成29年度日本生化学会九州支部例会 

松元太一、馬場梨沙子、大薗まみ、橋口周平、橋本雅仁   Acetobacter pasteurianus 由来外膜小胞の産生と性質  

平成29年度日本生化学会九州支部例会 

脇純平、今大路治之、大薗まみ、橋口周平、桑原知巳、橋本雅仁   Bacteroides fragilis 由来自然免疫活性化物質の検討  

平成29年度日本生化学会九州支部例会 

橋本雅仁、松元太一、馬場梨沙子、大薗まみ、橋口周平   酢酸菌由来外膜小胞の免疫刺激能  

第90回日本細菌学会総会 

Ryuji Miyahara, Yui Matsushita, Akiko Shimotsu, Taisuke Shinozaki, Masahito Hashimoto, Kazuhisa Sugimura, Shuhei Hashiguchi   M13 phage vaccine for Alzheimer’s disease that induce T-cell independent IgG response against Aβ peptide  

第45回日本免疫学会学術集会 

宮原隆二、下津尭子、松下由依、篠崎太亮、橋本雅仁、橋口周平   M13ファージペプチドワクチンの設計法：抗原分子の提示方法の違いと抗原性  

ファージ・環境ウイルス研究合同シンポジウム 

橋口周平、宮原隆二、塚田舞、岸本聡、篠崎太亮、橋本雅仁、加藤太一郎、伊東祐二   抗体ライブラリを用いたin vivoパニングによる血液脳関門透過性抗体の探索  

ファージ・環境ウイルス研究合同シンポジウム 

下津尭子、中西美加、宮原隆二、松下由依、篠崎太亮、橋本雅仁、橋口周平   M13ファージ不活化ワクチンが誘導する抗体応答の検討  

第40回蛋白質と酵素の構造と機能に関する九州シンポジウム 

松下由依、宮原隆二、下津尭子、篠崎太亮、中西美加、橋本雅仁、橋口周平   ヘルパーT細胞エピトープを欠損したM13ファージの構築  

第40回蛋白質と酵素の構造と機能に関する九州シンポジウム 

Ryuji Miyahara, Akiko Shimotsu, Yui Matsushita, Mai Tsukada, Masahito Hashimoto, Kazuhisa Sugimura, Shuhei Hashiguchi   Immunogenicity of M13 phage vaccine displaying N-terminal region of amyloid beta peptide: comparison of M13 phage vaccine expressed as g3p fusion and g8p fusion   International conference

International Congress of Immunology 2016 

宮原隆二、下津尭子、松下由衣、篠崎太亮、橋本雅仁、橋口周平   抗アミロイドβ抗体を誘導するアルツハイマー認知症ファージワクチンの開発  

平成28年度日本生化学会九州支部例会 

下津尭子、松下由衣、宮原隆二、篠崎太亮、橋本雅仁、橋口周平   M13ファージが誘導する抗体の抗原特異性に関する検討  

平成28年度日本生化学会九州支部例会 

篠崎太亮、宮原隆二、松下由衣、下津尭子、橋本雅仁、橋口周平   M13ファージを担体としたスギ花粉症脱感作ワクチンの設計：抗原分子の提示方法の違いと抗原性  

平成28年度日本生化学会九州支部例会 

宮原隆二, 下津尭子、 松下由依、塩屋亮平、庄司 恵二、杉村 和久、橋口 周平   M13ファージを担体に用いたアルツハイマー認知症ワクチンの開発  

BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会) 

橋口周平   アジュバントの添加を必要としない繊維状ファージ (M13) を担体としたファージワクチンの開発   Invited

第158回日本獣医学会学術集会 

橋口周平   自然免疫を活性化するM13ファージを担体としたファージワクチン  

第2回ファージセラピー臨床応用検討会 

橋口周平、泊大介、宮原隆二、塩屋亮平、杉村和久   スギ花粉アレルゲンCry j 1のIgE結合エピトープを提示したファージワクチンによる脱感作効果の検討  

第64回日本アレルギー学会学術大会 

Kazuhisa Sugimura, Ryuji Miyahara, Daisuke Tomari, Ryohei Shioya, Yoshitsugu Shoji, Masaya Toyonaga, Shuhei Hashiguchi.   M13 bacteriophage for a vaccine vehicle.  

Annual Meeting of The Japanese Society for Immunology, 2013  Annual Meeting of The Japanese Society for Immunology, 2013

Masaya Toyonaga, Shoji Yoshitsugu, Shuhei Hashiguchi, Kazuhisa Sugimura.   Medical application of peptide-displaying M13 phage for vaccine vehicle.   International conference

4th Asia-Pacific International Peptide Symposium and 50th Japanese Peptide Symposium (APIPS2013)  4th Asia-Pacific International Peptide Symposium and 50th Japanese Peptide Symposium (APIPS2013)

Shuhei Hashiguchi and Kazuhisa Sugimura   M13 bacteriophage for a vaccine vehicle.   International conference

Phage2013  Phage2013

Shuhei Hashiguchi, Masaya Toyonaga, Yoshitsugu Shoji, Takuma Gotanda, Kazuhisa Sugimura.   Characterization of antibody responses to M13 phage vaccine: MyD88-dependent and T-cell independent IgG subclass responses.   International conference

International Congress of Immunology 2013  International Congress of Immunology 2013

Sugimura K, Osako T, Kawabata S, Miyahara R, Tsurumaru T, Oda R, Tomari D, Shioya R, Hashiguchi S.   Immunological characterization of M13 phage vaccine.   International conference

International Congress of Immunology 2013  International Congress of Immunology 2013

Shuhei Hashiguchi, Takuma Gotanda, Masaya Toyonaga, Kenji Uehara, Teppei Osako, Tsuyoshi Tsurumaru, Daisuke Tomari, Kazuhisa Sugimura   Immunological basis of M13 phage vaccine.  

第40回日本免疫学会総会・学術集会  第40回日本免疫学会総会・学術集会

豊永将也、橋口周平、五反田卓摩、上原健嗣、杉村和久   遺伝子組み換えM13ファージの不活化の検討とワクチンへの応用  

第85回日本生化学会大会  第85回日本生化学会大会

濱添勇太、橋口周平、杉村和久、石橋大輔、西田教行   プリオン阻害活性を示す抗プリオンタンパク質抗体による非感染神経芽腫細胞内でのPK抵抗性プリオンオリゴマーの生成  

第85回日本生化学会大会  第85回日本生化学会大会

Kawabata S, Osako T, Abe R, Hashiguchi S, Nakagawa S, Sugimura K.   B6-C15 peptide motif as a probe for immunotherapy and biomarker for Alzheimer's Disease.  

第49回ペプチド討論会  第49回ペプチド討論会

Tsurumaru T, Oda R, Osako T, Uehara K, Gotanda T, Hashiguchi S, Sugimura K.   Influenza virus vaccine using phage display technology.  

第49回ペプチド討論会  第49回ペプチド討論会

橋口周平、豊永将也、五反田卓摩、上原健嗣、大迫哲平、鶴丸 毅、泊 大介、杉村和久   自然免疫を活性化するM13バクテリオファージのワクチンへの応用  

第4回ファージ研究会  第4回ファージ研究会

Hashiguchi S, Gotanda T, Hamazoe Y, Tsurumaru T, Sugimura K.   Strong innate immunity to M13 bacteriophage: Implication for vaccine development.   International conference

5th Vaccine and ISV Annual Global Congress  5th Vaccine and ISV Annual Global Congress

Sugimura K, Hashiguchi S, Osako T, Kawabata S, Abe R.   M13 bacteriophage for vaccine vehicle of Alzheimer's disease.   International conference

Phage2011  Phage2011

橋本 雅仁, 松元 太一, 中村 佳祐, 大薗 まみ, 橋口 周平   酢酸菌由来外膜小胞の収量改善の検討  

日本生物工学会大会講演要旨集  2018.8  (公社)日本生物工学会

橋本 雅仁, 馬場 梨沙子, 牧 百合恵, 大薗 まみ, 橋口 周平   酢酸菌由来外膜小胞の免疫調整能(Immunomodulatory effects of outer membrane vesicles from acetic acid bacteria)  

日本細菌学雑誌  2019.3  日本細菌学会

橋本 雅仁, 松元 太一, 馬場 梨沙子, 大薗 まみ, 橋口 周平   酢酸菌由来外膜小胞の免疫刺激能(Immunostimulatory effects of outer membrane vesicles from acetic acid bacteria)  

日本細菌学雑誌  2017.2  日本細菌学会

橋本 雅仁, 牧 百合恵, 大薗 まみ, 橋口 周平   酢酸菌由来外膜小胞による免疫細胞刺激  

日本生化学会大会プログラム・講演要旨集  2019.9  (公社)日本生化学会

宮原 隆二, 篠崎 太亮, 中西 美加, 中川路 けい, 橋本 雅仁, 橋口 周平   抗原エピトープ特異的IgG抗体を誘導するファージワクチンの分子設計法  

日本獣医学会学術集会講演要旨集  2017.8  (公社)日本獣医学会

橋口 周平, 辻村 誠一   メタマー光環境がマウスのアクティビティに与える影響に関する検討  

日本獣医学会学術集会講演要旨集  2017.8  (公社)日本獣医学会

Nakagawaji Kei, Hashiguchi Shuhei, Murakami Akikazu, Hashimoto Masahito   ウイルス感染　炎症性cytokine産生のないマウスマクロファージによるM13ファージワクチンの選択的取込み(Virus infection　Preferential uptake of M13 phage vaccine by murine macrophages without the production of proinflammatory cytokines)  

日本免疫学会総会・学術集会記録  2018.12  (NPO)日本免疫学会

Tsukahara Narutoshi, Kitade Nozomi, Yonamine Shuhei, Hashiguchi Shuhei, Murakami Akikazu, Kishimoto Hidehiro   ウイルス感染　二つの異なるphage display systemの融合によるワクチン候補peptide迅速同定システムの開発(Virus infection　Development of rapid identification system of vaccine candidate peptides by fusing two different phage display systems)  

日本免疫学会総会・学術集会記録  2018.12  (NPO)日本免疫学会

三輪 龍馬, 橋口 周平, 橋本 雅仁   Bacteroides fragilis莢膜多糖の研究  

日本生化学会大会プログラム・講演要旨集  2020.9  (公社)日本生化学会

橋本 雅仁, 松元 太一, 中村 佳祐, 馬場 梨沙子, 大薗 まみ, 橋口 周平   Acetobacter pasteurianus由来外膜小胞の分離と免疫刺激能  

生命科学系学会合同年次大会  2017.12  生命科学系学会合同年次大会運営事務局

馬場 梨沙子, 池田 剛, 橋口 周平, 橋本 雅仁   Acetobacter pasteurianus由来リポ多糖のO抗原多糖の化学構造解析  

生命科学系学会合同年次大会  2017.12  生命科学系学会合同年次大会運営事務局

馬場 梨沙子, 池田 剛, 橋口 周平, 橋本 雅仁   Acetobacter pasteurianusリポ多糖の多糖画分の化学構造解析  

日本細菌学雑誌  2018.2  日本細菌学会

牧 百合恵, 大薗 まみ, 橋口 周平, 橋本 雅仁   酢酸菌由来外膜小胞のアジュバント活性  

日本生化学会大会プログラム・講演要旨集  2021.11  (公社)日本生化学会

網膜メラノプシン細胞による生体への影響の解明：心理学・生物学・工学の手法を用いて

Grant number：20H00614  2020.4 - 2025.3

日本学術振興会  科学研究費助成事業 基盤研究(A)  基盤研究(A)

辻村 誠一, 沼野 利佳, 樋口 重和, 鯉田 孝和, 太田 英伸, 橋口 周平

天然ファージを利用したファージ製剤の開発に向けた研究

2019.10 - 2021.2

民間企業  一般受託研究 

ファージワクチンの免疫応答誘導メカニズムの解明とB細胞移入療法への応用の試み

Grant number：19K06386  2019.4 - 2022.3

日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

橋口 周平, 岩野 英知, 村上 明一

天然ファージを利用したファージ製剤の開発に向けた研究

2018.10 - 2019.2

民間企業  国内共同研究 

Development and clinical application of next-generation phage therapy

Grant number：17H01506  2017.4 - 2022.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

Iwano Hidetomo

Irradiance encoding process in the nonimage-forming pathway

Grant number：17H01808  2017.4 - 2021.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Tsujimura Sei-ichi

M13ファージワクチンによるB細胞活性化機構の解明とワクチン効果の検討

2016.4 - 2019.3

科学研究費補助金  基盤研究(C)

M13ファージワクチンによるB細胞活性化機構の解明とワクチン効果の検討

2016.4 - 2019.3

科学研究費補助金、基盤研究（Ｃ） 

橋口周平

T細胞非依存的にIgG抗体応答を誘導するアルツハイマー認知症ファージワクチン

2016.4 - 2017.3

九州大学  一般受託研究 

Design and basic reserch of novel antibody using Leucine Rich Repeat scaffold.

Grant number：15K06588  2015.4 - 2019.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

Yoshinaga Keisuke

M13ファージの生体における影響に関する免疫学的解析とワクチンへの応用

2013.4 - 2016.3

科学研究費補助金  基盤研究(C)

2. プリオン抗原をディスプレイするファージワクチンによる自己抗体の誘導と免疫制御

2010.4 - 2012.3

科学研究費補助金  若手研究(B)

コンフォメーション特異的抗体による簡便で高精度なBSE診断法の開発研究

2010.4 - 2012.3

厚生労働省  科学技術振興調整費 

抗体エンジニアリングによるプリオン病の早期診断法の開発

2004.4 - 2006.3

科学研究費補助金  基盤研究(C)

5. 抗体エンジニアリングによる免疫制御分子の開発

2002.4 - 2004.3

科学研究費補助金  若手研究(B)