Updated on 2022/12/22

写真a

 
HANAYA Ryosuke
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Neurology Professor
Title
Professor

Degree

  • 博士(医学) ( 1998.3   広島大学 )

Research Interests

  • 機能脳神経外科

  • 脳神経外科

  • てんかん

Research Areas

  • Others / Others  / 神経薬理学

  • Others / Others  / 機能的脳神経疾患の外科治療

  • Others / Others  / 脳腫瘍の治療

  • Others / Others  / てんかんの外科治療

  • Life Science / Neurosurgery

Research History

  • Kagoshima University   Professor

    2022.4

  • 鹿児島大学大学院   医歯学総合研究科脳神経外科   教授

    2022.4

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Neurology   Associate Professor

    2019.1 - 2022.3

  • Kagoshima University   Graduate School of Medical and Dental Sciences   Associate Professor

    2019.1 - 2022.3

  • Kagoshima University   Hospital   Lecturer

    2017.4 - 2018.12

  • Kagoshima University   Hospital

    2011.11 - 2017.3

  • Kagoshima University   Medical and Dental Hospital, Medical and Dental Sciences Area Medical and Dental Hospital Clinical Center Neurology Disease Center   Lecturer

    2008.4 - 2018.12

▼display all

Professional Memberships

  • 日本小児神経学会

    2013.4

  • 日本脳卒中学会

    2013.4

  • 日本神経減圧術学会

    2011.4

  • 日本脳腫瘍の外科学会

    2009.9

  • 日本臨床神経生理学会

    2009.4

  • 日本臨床薬理学会

    2008.10

  • 日本定位・脳機能神経外科学会

    2008.9

  • American Epilepsy Society

    2007.5

  • THE JAPANESE CONGRESS OF NEUROLOGICAL SURGEONS

    1996.9

  • 日本薬理学会

    1995.2

  • 日本てんかん外科学会

    1994.10

  • 日本てんかん学会

    1994.5

  • 日本脳神経外科学会

    1990.6

▼display all

Committee Memberships

  • 鹿児島県てんかん治療医療連携協議会委員会   てんかん治療医療連携協議会委員  

    2019.12   

 

Papers

  • Kirishima M., Akahane T., Higa N., Suzuki S., Ueno S., Yonezawa H., Uchida H., Hanaya R., Yoshimoto K., Shimajiri S., Kitazono I., Tanimoto A. .  IDH-mutant astrocytoma with an evolutional progression to CDKN2A/B homozygous deletion and NTRK fusion during recurrence: A case report .  Pathology Research and Practice239   154163   2022.11

     More details

    Language:Japanese   Publisher:Pathology Research and Practice  

    We reported a case of molecularly defined isocitrate dehydrogenase (IDH)-mutant astrocytoma that recurred twice with aggressive behavior and increased anaplastic morphology. Primary and recurrent tumors were analyzed using custom-made DNA-based cancer gene and RNA-based fusion panels for next-generation sequencing (NGS). NGS analyses revealed that recurrent astrocytoma, in addition to IDH1 and tumor protein 53 mutations detected in the primary lesion, harbored cyclin-dependent kinase inhibitor (CDKN) 2 A/B homozygous deletion and neurotrophic tropomyosin receptor kinase 2 (NTRK2) fusion genes that consisted of golgin A1- and cyclin-dependent kinase 5 regulatory subunit associated protein 2-NTRK2 fusions. Anaplasia and necrosis were observed in the recurrent tumors, but not in the primary lesion. Therefore, the integrative diagnosis was primary IDH-mutant astrocytoma grade 2 and recurrent IDH-mutant astrocytoma grade 4 with NTRK2 fusions. This is a worthwhile report describing a case of IDH-mutant astrocytoma that showed genomic evolution during tumor recurrence. Our report suggests that NTRK fusion and CDKN2A/B homozygous deletion promote high-grade transformation and indicate an unfavorable prognosis of IDH-mutant astrocytoma.

    DOI: 10.1016/j.prp.2022.154163

    Scopus

    PubMed

  • Higa Nayuta, Akahane Toshiaki, Yokoyama Seiya, Yonezawa Hajime, Uchida Hiroyuki, Fujio Shingo, Kirishima Mari, Takigawa Kosuke, Hata Nobuhiro, Toh Keita, Yamamoto Junkoh, Hanaya Ryosuke, Tanimoto Akihide, Yoshimoto Koji .  Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel(和訳中) .  Neurologia medico-chirurgica62 ( 9 ) 391 - 399   2022.9Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel(和訳中)

     More details

    Language:English   Publisher:(一社)日本脳神経外科学会  

  • Makino R., Fujio S., Hanada T., Yonenaga M., Kawade S., Hashiguchi H., Nishio Y., Higa N., Arita K., Yoshimoto K., Hanaya R. .  Delayed postoperative hyponatremia in patients with acromegaly: incidence and predictive factors .  Pituitary   2022

     More details

    Language:Japanese   Publisher:Pituitary  

    Purpose: Delayed postoperative hyponatremia (DPH) is a unique complication of transsphenoidal surgery (TSS) in pituitary tumors. Growth hormone (GH) enhances renal sodium reabsorption; however, the association between postoperative GH reduction and DPH in acromegaly is unclear. This study was performed to clarify the incidence of and the predictive factors for DPH in patients with acromegaly who underwent TSS. Methods: Ninety-four patients with active acromegaly were examined retrospectively. During the postoperative course, patients with serum sodium levels ≤ 134 mEq/L were classified into the DPH group. We compared basic clinical characteristics, tumor characteristics, and preoperative and postoperative examination findings between the DPH and non-DPH groups. Results: DPH occurred in 39 patients (41.5%), and the lowest serum sodium levels were generally observed during postoperative days (PODs) 7–9. They needed a 3-day longer hospital stay than those without DPH. The DPH group had lower preoperative body weight and body mass index. In addition, a transient increase in body weight during PODs 5–7 occurred with a transient decrease in urinary volume in the DPH group. Preoperative and postoperative GH and insulin-like growth factor-1 levels did not differ between the two groups. Conclusion: The findings suggested that lower preoperative weight and a postoperative transient gain in body weight are associated with an increased risk of DPH in acromegaly patients undergoing transsphenoidal surgery.

    DOI: 10.1007/s11102-022-01288-y

    Scopus

    PubMed

  • Sato M., Oyoshi T., Iwamoto H., Tanoue N., Komasaku S., Higa N., Hosoyama H., Tokimura H., Ibara S., Hanaya R., Yoshimoto K. .  The collagen matrix dural substitute graft prevents postoperative cerebrospinal fluid leakage after ventriculoperitoneal shunt surgery in patients aged <1 year .  Surgical Neurology International13   461   2022

     More details

    Language:Japanese   Publisher:Surgical Neurology International  

    Background: Cerebrospinal fluid (CSF) leakage is a common complication of ventriculoperitoneal shunt (VPS) and has the potential to induce shunt infection. Especially in infants and children, these are serious complications. DuraGen is a collagen matrix dural substitute used to reduce the risk of CSF leakage in various neurosurgeries. We report our VPS procedure with DuraGen for preventing postoperative CSF leakage in patients aged <1 year. Methods: We used DuraGen to prevent postoperative CSF leakage in six VPS surgeries. Antibiotic-impregnated shunt catheters and programmable valves with anti-siphon devices were also used in all cases. DuraGen was placed inside and atop the burr hole. All cases had an initial shunt pressure of 5 cmH2O. Fibrin glue was not used. Results: The patients underwent follow-up for a year after VPS surgery. There was no postoperative subcutaneous CSF collection or leakage after all six VPS surgeries. Furthermore, no postoperative shunt infections or DuraGen-induced adverse events were noted. Conclusion: We speculate that DuraGen has a preventive effect on postoperative CSF leakage in VPS cases aged <1 year.

    DOI: 10.25259/SNI_629_2022

    Scopus

    PubMed

  • Thapa S., Yamahata H., Okada T., Yonenaga M., Bajagain M., Makino R., Hanaya R. .  Spinal intradural solitary fibrous tumor/ hemangiopericytoma with intramedullary invasion mimicking a hemangioblastoma .  Surgical Neurology International13   443   2022

     More details

    Language:Japanese   Publisher:Surgical Neurology International  

    Background: Solitary fibrous tumor/hemangiopericytomas (SFT/HPCs) are rare mesenchymal tumors of nonmeningothelial origin that comprises <1% of all central nervous system tumors. Case Description: A 45-year-old male presented with sleep apnea (apnea-hypopnea index was 17.1 events/hour) and dysesthesias of the right upper and lower extremities. The magnetic resonance demonstrated a heterogeneous intradural extra-axial C1 mass with syringobulbia and syringomyelia. The right vertebral angiography revealed a hypervascular mass (i.e., intense tumor staining). With the preoperative diagnosis of a spinal hemangioblastoma, the patient underwent tumor removal. However, intraoperative findings demonstrated that the ventral component of the tumor was intramedullary without a dural attachment. Further, the histological diagnosis was consistent with SFT/HPC (HPC phenotype). The postoperative course was uneventful, and the patient’s symptoms and the syrinxes spontaneously regressed. Conclusion: A 45-year-old male presented a rare spinal intradural lesion at C1 appeared to be a spinal hemangioblastoma, but proved to be SFT/HPC (HPC phenotype) with intramedullary invasion.

    DOI: 10.25259/SNI_655_2022

    Scopus

    PubMed

  • Kuroda N. .  Risk factors for psychological distress in electroencephalography technicians during the COVID-19 pandemic: A national-level cross-sectional survey in Japan .  Epilepsy and Behavior125   2021.12

     More details

    Language:Japanese   Publisher:Epilepsy and Behavior  

    DOI: 10.1016/j.yebeh.2021.108361

    Scopus

  • Makino R. .  Radiological comparison of the midpoint of the nasion-inion line and the external auditory canal for measuring the cranial center of the gravity-sagittal vertical axis .  Interdisciplinary Neurosurgery: Advanced Techniques and Case Management26   2021.12

     More details

    Language:Japanese   Publisher:Interdisciplinary Neurosurgery: Advanced Techniques and Case Management  

    DOI: 10.1016/j.inat.2021.101299

    Scopus

  • Muchamad Galih Ricci, Hanaya Ryosuke, Maruyama Shinsuke, Yonee Chihiro, Hosoyama Hiroshi, Baba Yusei, Sato Masanori, Sano Nozomi, Otsubo Toshiaki, Yoshimoto Koji .  持続的なけいれん群発に対する迷走神経刺激の効果 症例報告(Effects of Vagus Nerve Stimulation on Sustained Seizure Clusters: A Case Report) .  NMC Case Report Journal8 ( 1 ) 123 - 128   2021持続的なけいれん群発に対する迷走神経刺激の効果 症例報告(Effects of Vagus Nerve Stimulation on Sustained Seizure Clusters: A Case Report)

     More details

    Language:English   Publisher:(一社)日本脳神経外科学会  

    症例は13歳男児で、先天性脳性麻痺と精神遅滞があった。過去にウエスト症候群と診断され、副腎皮質刺激ホルモン療法を受けたが、毎日のように体の両側に筋反射や痙攣を伴う薬剤抵抗性のてんかんを発症していた。11歳時に約1分間続く強直発作を呈し、数分おきに数回繰り返された。てんかん重積の診断に基づき、ミダゾラム持続静脈注射(IV-MDZ)や経口薬などで薬物治療が行われ、1分未満の強直発作を1日2〜8回繰り返す散発性けいれん群発(SC)が月に1〜2回発生する状態になった。2年後、持続性SCを呈してミダゾラム持続静脈注射(IV-MDZ)や経口薬などで薬物治療が行われたが改善しなかった。迷走神経刺激(VNS)デバイスを植え込み、VNSを迅速に導入した。IV-MDZを漸減させてもSCが悪化しなかったため、VNS導入4週間後にMDZを中止した。難治性でないSCもVNSの10ヵ月後には消失した。発作の重症度は改善し、頻度は毎日から数ヵ月に1回に減少した。脳波上のてんかん活動も有意に低下した。

  • Iwamoto Hirofumi, Hanaya Ryosuke, Brilliantika Surya Pratama, Sato Masanori, Hosoyama Hiroshi, Otsubo Toshiaki, Umehara Fujio, Yoshimoto Koji .  Surgical Treatment for Mesial Temporal Lobe Epilepsy Accompanied with Neuro-Behcet's Disease: A Case Report(和訳中) .  NMC Case Report Journal8 ( 1 ) 405 - 411   2021Surgical Treatment for Mesial Temporal Lobe Epilepsy Accompanied with Neuro-Behcet's Disease: A Case Report(和訳中)

     More details

    Language:English   Publisher:(一社)日本脳神経外科学会  

    症例は22歳男性で、頭痛、めまい、失見当識、全般発作を呈していた。小児期からの再発性口内潰瘍および結節性紅斑の既往歴、てんかんの家族歴があった。MRIにて脳橋に病変が認められた。ステロイドパルス療法を行ったところ、症状の改善が認められた。しかし、発症から1年後に再発を認め、神経ベーチェット病(NBD)と診断された。MRI T2強調画像にて、脳幹、小脳、右内側側頭葉、両側基底核に高信号が認められた。また、左海馬の萎縮も認めた。ステロイドおよび免疫抑制剤の投与により、NBDはコントロールされた。しかし、NBD発症から3年後、内側側頭葉てんかんを発症した。薬剤耐性となり、NBD発症から12年後に手術が検討された。術前MRIにて左海馬硬化が認められた。NBD発症から13年後に左側頭葉前部切除術が施行された。術後2年以上、無発作状態が認められた。

  • KOMASAKU Soichiro, HANAYA Ryosuke, YONENAGA Masanori, KUBO Fumikatsu, EIRAKU Naoto, YAMASAKI Fumiyuki, ARITA Kazunori, YOSHIMOTO Koji .  Symptomatic Developmental Venous Anomaly with an Increased β2-microglobulin Level in Cerebrospinal Fluid: A Case Report .  Hiroshima Journal of Medical Sciences68 ( 1 ) 13 - 18   2019.3

     More details

    Language:English   Publisher:Hiroshima University Medical Press  

    <p>Background: Gadolinium-enhanced magnetic resonance imaging (MRI) can be used to observe the progression of cerebral infarction, which sometimes mimics malignant brain tumors. While the β2-microglobulin (β2MG) level in blood plasma or cerebrospinal fluid (CSF) is useful for the diagnosis of malignant tumors or degenerative diseases, these results may create confusion regarding a definitive diagnosis, because it is not a specific marker. We present a rare case of symptomatic developmental venous anomaly (DVA), accompanied by transient, irregular, enhanced cerebral lesions and elevated β2MG in the CSF.</p><p>Case Description: A 56-year-old woman developed dysarthria and underwent MRI, which revealed a right frontal hyperintense area around a previous lesion on diffusion-weighted imaging (DWI). She was treated based on the tentative diagnosis of an ischemic cerebrovascular event, and symptoms subsided in 3 days. MRI on day 7 revealed an enlargement of the hyperintense area on DWI. Post-gadolinium MRI showed multiple, enhanced patchy areas in the right frontal lobe and an abnormally large vein connected to dilated medullary venules, indicating DVA. Magnetic resonance angiography showed no stenosis or arterial occlusion. The β2MG level in the CSF was elevated at 2,061 μg/l, and a differential diagnosis from malignant tumor was required. However, MRI on day 23 revealed total disappearance of the enhanced lesions and a decrease in the high intensity area on DWI. Considering the clinical course, the DVA was symptomatic because of the perfusion disturbance.</p><p>Conclusion: Careful evaluation is necessary when considering the associated pathologies and potential complications of DVA if detected near a gadolinium-enhanced lesion.</p>

    DOI: 10.24811/hjms.68.1_13

  • 花谷 亮典, 細山 浩史, 佐藤 雅紀, 飯田 幸治 .  てんかん外科のススメ―治療選択を広げるために― .  てんかん研究36 ( 3 ) 657 - 662   2019.1

     More details

    Language:Japanese   Publisher:一般社団法人 日本てんかん学会  

    DOI: 10.3805/jjes.36.657

  • HIGA Nayuta, AKAHANE Toshiaki, YOKOYAMA Seiya, YONEZAWA Hajime, UCHIDA Hiroyuki, FUJIO Shingo, KIRISHIMA Mari, TAKIGAWA Kosuke, HATA Nobuhiro, TOH Keita, YAMAMOTO Junkoh, HANAYA Ryosuke, TANIMOTO Akihide, YOSHIMOTO Koji .  Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel .  Neurologia medico-chirurgica62 ( 9 ) 391 - 399   2022.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japan Neurosurgical Society  

    <p>Rapid technological advances in molecular biology, including next-generation sequencing, have identified key genetic alterations in central nervous system (CNS) tumors. Accordingly, the fifth edition of the World Health Organization (WHO) CNS tumor classification was published in 2021. We analyzed 303 patients with diffuse glioma using an amplicon-based glioma-tailored gene panel for detecting 1p/19q codeletion and driver gene mutations such as <i>IDH1/2</i>, <i>TERTp</i>, <i>EGFR</i>, and <i>CDKN2A/B</i> on a single platform. Within glioblastomas (GBMs), the most commonly mutated genes were <i>TERTp</i>, <i>TP53</i>, <i>PTEN</i>, <i>NF1</i>, and <i>PDGFRA</i>, which was the most frequently mutated tyrosine kinase receptor in GBM, followed by <i>EGFR</i>. The genes that most commonly showed evidence of loss were <i>PTEN</i>, <i>CDKN2A/B</i>, and <i>RB1</i>, whereas the genes that most commonly showed evidence of gain/amplification were <i>EGFR</i>, <i>PDGFRA</i>, and <i>CDK4</i>. In 22 grade III oligodendroglial tumors, 3 (14%) patients had <i>CDKN2A/B</i> homozygous deletion, and 4 (18%) patients had <i>ARID1A</i> mutation. In grade III oligodendroglial tumors, an <i>ARID1A</i> mutation was associated with worse progression-free survival. Reclassification based on the WHO 2021 classification resulted in 62.5% of grade II/III <i>isocitrate dehydrogenase</i> (<i>IDH</i>) -wildtype astrocytomas being classified as <i>IDH</i>-wildtype GBM and 37.5% as not elsewhere classified. In summary, our glioma-tailored gene panel was applicable for molecular diagnosis in the WHO 2021 classification. In addition, we successfully reclassified the 303 diffuse glioma cases based on the WHO 2021 classification and clarified the genetic profile of diffuse gliomas in the Japanese population.</p>

    DOI: 10.2176/jns-nmc.2022-0103

    Scopus

    PubMed

  • Nayuta Higa, Toshiaki Akahane, Seiya Yokoyama, Hajime Yonezawa, Hiroyuki Uchida, Tomoko Takajo, Ryosuke Otsuji, Taiji Hamada, Kei Matsuo, Mari Kirishima, Nobuhiro Hata, Ryosuke Hanaya, Akihide Tanimoto, Koji Yoshimoto .  Prognostic impact of <i>PDGFRA</i> gain/amplification and <i>MGMT</i> promoter methylation status in patients with <i>IDH</i> wild-type glioblastoma .  Neuro-Oncology Advances4 ( 1 ) vdac097   2022.6

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    Background

    Platelet-derived growth factor receptor alpha (PDGFRA) is the second most frequently mutated tyrosine kinase receptor in glioblastoma (GBM). However, the prognostic impact of PDGFRA amplification on GBM patients remains unclear. Herein, we evaluated this impact by retrospectively analyzing outcomes of patients with IDH wild-type GBM.

    Methods

    Using a custom-made oncopanel, we evaluated PDGFRA gain/amplification in 107 GBM samples harboring wild-type IDH, along with MGMT promoter (MGMTp) methylation status.

    Results

    We detected PDGFRA gain/amplification in 31 samples (29.0%). PDGFRA gain/amplification predicted poor prognosis (P = .003). Compared to unamplified PDGFRA, PDGFRA gain/amplification in GBM was associated with higher patient age (P = .031), higher Ki-67 score (P = .019), and lower extent of surgical resection (P = .033). Unmethylated MGMTp also predicted poor prognosis (P = .005). As PDGFRA gain/amplification and unmethylated MGMTp were independent factors for poor prognosis in multivariate analyses, we grouped GBM cases based on PDGFRA and MGMTp status: poor (PDGFRA gain/amplification and unmethylated MGMTp), intermediate (PDGFRA gain/amplification or unmethylated MGMTp), and good (PDGFRA intact and methylated MGMTp) prognosis. The Kaplan-Meier survival analysis indicated that these groups significantly correlated with the OS of GBM patients (P &amp;lt; .001).

    Conclusions

    Here we report that PDGFRA gain/amplification is a predictor of poor prognosis in IDH wild-type GBM. Combining PDGFRA gain/amplification with MGMTp methylation status improves individual prognosis prediction in patients with IDH wild-type GBM.

    DOI: 10.1093/noajnl/vdac097

    Scopus

    PubMed

    Other Link: https://academic.oup.com/noa/article-pdf/4/1/vdac097/45178840/vdac097.pdf

  • Nayuta Higa, Toshiaki Akahane, Taiji Hamada, Hajime Yonezawa, Hiroyuki Uchida, Ryutaro Makino, Shoji Watanabe, Tomoko Takajo, Seiya Yokoyama, Mari Kirishima, Kei Matsuo, Shingo Fujio, Ryosuke Hanaya, Akihide Tanimoto, Koji Yoshimoto .  Distribution and favorable prognostic implication of genomic EGFR alterations in IDH-wildtype glioblastoma. .  Cancer medicine   2022.6Distribution and favorable prognostic implication of genomic EGFR alterations in IDH-wildtype glioblastoma.International journal

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: We aimed to evaluate the mutation profile, transcriptional variants, and prognostic impact of the epidermal growth factor receptor (EGFR) gene in isocitrate dehydrogenase (IDH)-wildtype glioblastomas (GBMs). METHODS: We sequenced EGFR, evaluated the EGFR splicing profile using a next-generation sequencing oncopanel, and analyzed the outcomes in 138 grade IV IDH-wildtype GBM cases. RESULTS: EGFR mutations were observed in 10% of GBMs. A total of 23.9% of the GBMs showed EGFR amplification. Moreover, 25% of the EGFR mutations occurred in the kinase domain. Notably, EGFR alterations were a predictor of good prognosis (p = 0.035). GBM with EGFR alterations was associated with higher Karnofsky Performance Scale scores (p = 0.014) and lower Ki-67 scores (p = 0.005) than GBM without EGFR alterations. EGFRvIII positivity was detected in 21% of EGFR-amplified GBMs. We identified two other EGFR variants in GBM cases with deletions of exons 6-7 (Δe 6-7) and exons 2-14 (Δe 2-14). In one case, the initial EGFRvIII mutation transformed into an EGFR Δe 2-14 mutation during recurrence. CONCLUSIONS: We found that the EGFR gene profiles of GBM differ among cohorts and that EGFR alterations are good prognostic markers of overall survival in patients with IDH-wildtype GBM. Additionally, we identified rare EGFR variants with longitudinal and temporal transformations of EGFRvIII.

    DOI: 10.1002/cam4.4939

    PubMed

  • Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Izumi Kuramochi, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Yutaro Takayama, Daichi Sone, Kousuke Kanemoto, Akio Ikeda, Kiyohito Terada, Hiroko Goji, Shinji Ohara, Koichi Hagiwara, Takashi Kamada, Koji Iida, Nobutsune Ishikawa, Hideaki Shiraishi, Osato Iwata, Hidenori Sugano, Yasushi Iimura, Takuichiro Higashi, Hiroshi Hosoyama, Ryosuke Hanaya, Akihiro Shimotake, Takayuki Kikuchi, Takeshi Yoshida, Hiroshi Shigeto, Jun Yokoyama, Takahiko Mukaino, Masaaki Kato, Masanori Sekimoto, Masahiro Mizobuchi, Yoko Aburakawa, Masaki Iwasaki, Eiji Nakagawa, Tomohiro Iwata, Kentaro Tokumoto, Takuji Nishida, Yukitoshi Takahashi, Kenjiro Kikuchi, Ryuki Matsuura, Shin-Ichiro Hamano, Ayataka Fujimoto, Hideo Enoki, Kyoichi Tomoto, Masako Watanabe, Youji Takubo, Toshihiko Fukuchi, Hidetoshi Nakamoto, Yuichi Kubota, Naoto Kunii, Yuichiro Shirota, Eiichi Ishikawa, Nobukazu Nakasato, Taketoshi Maehara, Motoki Inaji, Shunsuke Takagi, Takashi Enokizono, Yosuke Masuda, Takahiro Hayashi .  Impact of COVID-19 pandemic on epilepsy care in Japan: A national-level multicenter retrospective cohort study. .  Epilepsia open   2022.5Impact of COVID-19 pandemic on epilepsy care in Japan: A national-level multicenter retrospective cohort study.International journal

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: The impact of the coronavirus disease 2019 (COVID-19) pandemic on epilepsy care across Japan was investigated by conducting a multicenter retrospective cohort study. METHODS: This study included monthly data on the frequency of (1) visits by outpatients with epilepsy, (2) outpatient electroencephalography (EEG) studies, (3) telemedicine for epilepsy, (4) admissions for epilepsy, (5) EEG monitoring, and (6) epilepsy surgery in epilepsy centers and clinics across Japan between January 2019 and December 2020. We defined the primary outcome as epilepsy-center-specific monthly data divided by the 12-month average in 2019 for each facility. We determined whether the COVID-19 pandemic-related factors (such as year [2019 or 2020], COVID-19 cases in each prefecture in the previous month, and the state of emergency) were independently associated with these outcomes. RESULTS: In 2020, the frequency of outpatient EEG studies (-10.7%, p<0.001) and cases with telemedicine (+2,608%, p=0.031) were affected. The number of COVID-19 cases was an independent associated factor for epilepsy admission (-3.75*10-3 % per case, p<0.001) and EEG monitoring (-3.81*10-3 % per case, p = 0.004). Further, the state of emergency was an independent factor associated with outpatient with epilepsy (-11.9%, p<0.001), outpatient EEG (-32.3%, p<0.001), telemedicine for epilepsy (+12,915%, p<0.001), epilepsy admissions (-35.3%; p<0.001), EEG monitoring (-24.7%: p<0.001), and epilepsy surgery (-50.3%, p<0.001). SIGNIFICANCE: We demonstrated the significant impact that the COVID-19 pandemic had on epilepsy care. These results support those of previous studies and clarify the effect size of each pandemic-related factor on epilepsy care.

    DOI: 10.1002/epi4.12616

    PubMed

  • Takashi Kawahara, Masamichi Atsuchi, Kazunori Arita, Shingo Fujio, Nayuta Higa, F M Moinuddin, Koji Yoshimoto, Ryosuke Hanaya .  Dural sac shrinkage signs on spinal magnetic resonance imaging indicate overdrainage after lumboperitoneal shunt for idiopathic normal pressure hydrocephalus. .  Surgical neurology international13   269 - 269   2022International journal

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Background: We previously found the usefulness of dural sac shrinkage signs (DSSSs), which are the anterior shift of the spinal cord and dura mater behind the cord, detected by magnetic resonance imaging (MRI) at the thoracic level for the diagnosis of spontaneous intracranial hypotension (IH). This is a retrospective survey on the usefulness of DSSSs for the early detection of iatrogenic IH caused by overdrainage through a lumboperitoneal shunt (LPS) for patients with idiopathic normal pressure hydrocephalus (INPH). Methods: Forty-five INPH patients had an LPS using a pressure programmable valve equipped with an anti-siphon device. Results: Nine patients complained of orthostatic headache after the LPS, indicating IH due to overdrainage, which persisted for more than a week in three patients and 2-7days in six patients. The headache was transient/ nonorthostatic in ten patients and absent in 26 patients. The DSSSs and accompanying enlargement of the venous plexus were observed in all three patients with prolonged orthostatic headaches. Only the anterior shift of the dura mater was observed in 1 (4%) among 25 patients who had short-term orthostatic headache, transient/ nonorthostatic headache, or absent headache, and underwent spinal MRI. A patient with prolonged severe orthostatic headache with both DSSSs eventually developed intracranial subdural effusion and underwent tandem valve surgery, which provided a quick improvement of symptoms. The DSSSs on thoracic MRI also disappeared promptly. Conclusion: DSSSs may serve as objective signs for the diagnosis of IH due to overdrainage through an LPS for INPH.

    DOI: 10.25259/SNI_291_2022

    Scopus

    PubMed

  • Thohar Arifin M. .  Initiating an epilepsy surgery program with limited resources in Indonesia .  Scientific Reports11 ( 1 ) 5066   2021.12

     More details

    Publisher:Scientific Reports  

    DOI: 10.1038/s41598-021-84404-5

    Scopus

    PubMed

  • Takaaki Hiwatari, Hitoshi Yamahata, Masanori Yonenaga, Shingo Fujio, Nayuta Higa, Ryosuke Hanaya, Kazunori Arita, Koji Yoshimoto .  The incidence of depressed skull fractures due to the use of pin-type head frame systems in the adult population: 10-year experience of a single neurosurgical center. .  World neurosurgery155   e395 - e401   2021.8International journal

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Pin-type head frame systems have become a worldwide standard procedure, but they can cause some complications on rare occasions. This study aimed to examine the incidence and associated risk factors of depressed skull fracture and related intracranial hematoma (DSFH) due to the use of head frames in our institute over the past 10 years. METHODS: This study included 1,749 patients who underwent neurosurgical surgeries using pin-type head frames, including the Mayfield skull clamp (721 cases) and the Sugita head frame (1,028 cases). We retrospectively reviewed hospital records of our institute to identify cases of DSFH, and documented the type of head frame used, as well as patient characteristics. RESULTS: The incidence of DSFH was 0.29% (5/1,749 cases). All 5 cases had an associated epidural hematoma, with a single case having an additional dural laceration (without subdural damage). All perforation sites, located at the parietal bone near the pterion, occurred by the unilateral horizontal screw of the Sugita head frame. None of the patients experienced postoperative neurological decline. CONCLUSIONS: Even in the adult population, the DSFH by the pin-type head frame can occur infrequently. Based on our results, we recommend that the following factors should be considered when the pin-type head frame is used for neurosurgical procedures: the location of pin application, thickness and fragility of the skull, and adequate control of compressive forces exerted by the head frame.

    DOI: 10.1016/j.wneu.2021.08.070

    Scopus

    PubMed

  • Takashi Kawahara, Kazunori Arita, Shingo Fujio, Ryosuke Hanaya, Masamichi Atsuchi, F M Moinuddin, Muhammad Kamil, Tomohisa Okada, Hirofumi Hirano, Naoyuki Kitamura, Naoaki Kanda, Hitoshi Yamahata, Koji Yoshimoto .  Dural sac shrinkage signs on magnetic resonance imaging at the thoracic level in spontaneous intracranial hypotension-its clinical significance. .  Acta neurochirurgica163 ( 10 ) 2685 - 2694   2021.8International journal

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Spontaneous intracranial hypotension (SIH) is secondary to a cerebrospinal fluid leak at the spinal level without obvious causative events. Several signs on brain and cervical spine magnetic resonance (MR) imaging (MRI) have been associated with SIH but can be equivocal or negative. This retrospective study sought to identify characteristic SIH signs on thoracic spinal MRI. METHODS: Cranial and spinal MR images of 27 consecutive patients with classic SIH symptoms, who eventually received epidural autologous blood patches (EBPs), were analyzed. RESULTS: The most prevalent findings on T2-weighted MRI at the thoracic level were anterior shift of the spinal cord (96.3%) and dorsal dura mater (81.5%), probably caused by dural sac shrinkage. These dural sac shrinkage signs (DSSS) were frequently accompanied by cerebrospinal fluid collection in the posterior epidural space (77.8%) and a prominent epidural venous plexus (77.8%). These findings disappeared in all six patients who underwent post-EBP spinal MRI. Dural enhancement and brain sagging were minimum or absent on the cranial MR images of seven patients, although DSSS were obvious in these seven patients. For 23 patients with SIH and 28 healthy volunteers, a diagnostic test using thoracic MRI was performed by 13 experts to validate the usefulness of DSSS. The median sensitivity, specificity, positive-predictive value, negative-predictive value, and accuracy of the DSSS were high (range, 0.913-0.931). CONCLUSIONS: Detection of DSSS on thoracic MRI facilitates an SIH diagnosis without the use of invasive imaging modalities. The DSSS were positive even in patients in whom classic cranial MRI signs for SIH were equivocal or minimal.

    DOI: 10.1007/s00701-021-04933-w

    Scopus

    PubMed

  • Yoshifumi Mizobuchi, Shinji Nagahiro, Akinori Kondo, Kazunori Arita, Isao Date, Yukihiko Fujii, Takamitsu Fujimaki, Ryosuke Hanaya, Mitsuhiro Hasegawa, Toru Hatayama, Tooru Inoue, Hidetoshi Kasuya, Masahito Kobayashi, Eiji Kohmura, Toshio Matsushima, Jun Masuoka, Akio Morita, Shigeru Nishizawa, Yoshihiro Okayama, Taku Shigeno, Hiroshi Shimano, Hideo Takeshima, Iwao Yamakami .  Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study. .  Neurosurgery89 ( 4 ) 557 - 564   2021.7International journal

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Microvascular decompression (MVD) is the most effective procedure for the long-term management of trigeminal neuralgia (TGN). However, retrospective and single-center studies are inherently biased, and there are currently no prospective, multicenter studies. OBJECTIVE: To evaluate the short- and long-term outcomes and complications in patients with TGN who underwent MVD at specialized Japanese institutions. METHODS: We enrolled patients with TGN who underwent MVD between April 2012 and March 2015. We recorded their facial pain grade and complications at 7 d (short term), 1 yr (mid-term), and 3 yr (long term) postoperatively. RESULTS: There were 166 patients, comprising 60 men and 106 women (mean age 62.7 yr). Furthermore, 105 patients were aged over 60 yr. We conducted neuromonitoring in 84.3% of the cases. The complete pain relief, mortality, and complication rates at the short-term follow-up were 78.9%, 0%, and 16.3%, respectively. Overall, 155 patients (93.4%) completed the long-term follow-up, with the complete pain relief and complication rates of 80.0% and 5.2%, respectively. CONCLUSION: In the hands of experienced neurosurgeons, MVD for TGN can achieve high long-term curative effects. In addition, complications are uncommon and usually transient. Our results indicate that MVD is an effective and safe treatment for patients with TGN, including elderly patients.

    DOI: 10.1093/neuros/nyab229

    Scopus

    PubMed

  • Katagiri M. .  Interpersonal communication skills related to seizure outcomes in pediatric patients with vagus nerve stimulation .  Interdisciplinary Neurosurgery: Advanced Techniques and Case Management24   2021.6

     More details

    Publisher:Interdisciplinary Neurosurgery: Advanced Techniques and Case Management  

    DOI: 10.1016/j.inat.2020.101080

    Scopus

  • 山崎文之,高安武志,花谷亮典 .  高齢者グリオーマ .  脳神経外科49 ( 3 ) 647 - 659   2021.5高齢者グリオーマ

     More details

    Language:Japanese   Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1436204439

    PubMed

  • Mizobuchi Y. .  Prospective, Multicenter Clinical Study of Microvascular Decompression for Hemifacial Spasm .  Neurosurgery88 ( 4 ) 846 - 854   2021.3

     More details

    Publisher:Neurosurgery  

    DOI: 10.1093/neuros/nyaa549

    Scopus

    PubMed

  • Galih Ricci Muchamad, Ryosuke Hanaya, Shinsuke Maruyama, Chihiro Yonee, Hiroshi Hosoyama, Yusei Baba, Masanori Sato, Nozomi Sano, Toshiaki Otsubo, Koji Yoshimoto .  Effects of Vagus Nerve Stimulation on Sustained Seizure Clusters: A Case Report. .  NMC case report journal8 ( 1 ) 123 - 128   2021

     More details

    Language:English   Publisher:The Japan Neurosurgical Society  

    Seizure clusters (SCs) are acute repetitive seizures with acute episodes of deterioration during seizure control. SCs can be defined as a series of grouped seizures with short interictal periods. Vagus nerve stimulation (VNS) is a treatment option for drug-resistant epilepsy. We present a case where VNS suppressed epileptic SCs, which had persisted for several months. A 13-year-old boy with congenital cerebral palsy and mental retardation had drug-resistant epilepsy with daily jerking movements and spasms in both sides of his body. The seizures were often clustered, and he experienced two sustained SC episodes that persisted for a few months even with prolonged use of continuous intravenous midazolam (IV-MDZ). The patient underwent VNS device placement at the second sustained SC and rapid induction of VNS. Because the tapering of IV-MDZ did not exacerbate the SC, midazolam was discontinued 4 weeks after VNS initiation. Non-refractory SCs also disappeared 10 months after VNS. The seizure severity was improved, and the frequency of seizures reduced from daily to once every few months. The epileptic activity on electroencephalography (EEG) significantly decreased. This case highlights VNS as an additional treatment option for SC. VNS may be a therapeutic option if SC resists the drugs and sustains. Additional studies are necessary to confirm our findings and to investigate how device implantation and stimulation parameters affect the efficacy of VNS.

    DOI: 10.2176/nmccrj.cr.2020-0137

    PubMed

  • Hirofumi Iwamoto, Ryosuke Hanaya, Surya Pratama Brilliantika, Masanori Sato, Hiroshi Hosoyama, Toshiaki Otsubo, Fujio Umehara, Koji Yoshimoto .  Surgical Treatment for Mesial Temporal Lobe Epilepsy Accompanied with Neuro-Behçet's Disease: A Case Report. .  NMC case report journal8 ( 1 ) 405 - 411   2021

     More details

    Language:English   Publisher:The Japan Neurosurgical Society  

    Behçet's disease (BD) is a rare chronic inflammatory disease associated with systemic vasculitis. Involvement of the nervous system in BD is called neuro-BD (NBD). Epilepsy related to NBD is uncommon but responds well to anti-epileptic drugs. We present a case of NBD with drug-resistant mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis (HS). The patient presented with headache, dizziness, disorientation, and generalized seizures. Magnetic resonance imaging (MRI) identified pontine lesions. Chronic inflammation was suspected, and steroid pulse therapy improved his symptoms. He relapsed 1 year after onset and was diagnosed with NBD. MRI revealed bilateral mesial temporal lesions, with the right being edematous and the left atrophic. NBD was controlled by steroid and immunosuppressive medication. Three years after the onset of NBD, the patient suffered MTLE, and MRI suggested left hippocampal atrophy. His seizures became drug-resistant and surgical therapy was considered 12 years after NBD onset. Pre-surgical MRI clearly showed left HS. After evaluations, the patient had left anterior temporal lobectomy (ATL) 13 years after NBD onset under stable NBD. The patient was seizure-free for > 2 years after surgery. Surgery will be an effective treatment for drug-resistant MTLE with HS even in patients with NBD, of course the effects of surgical intervention should be considered.

    DOI: 10.2176/nmccrj.cr.2020-0218

    PubMed

  • Arifin M.T. .  Surgery for Radiologically Normal-Appearing Temporal Lobe Epilepsy in a Centre with Limited Resources .  Scientific Reports10 ( 1 ) 8144   2020.12

     More details

    Publisher:Scientific Reports  

    DOI: 10.1038/s41598-020-64968-4

    Scopus

    PubMed

  • Arifin M.T. .  Preoperative sensory aura predicts risk for seizure in temporal lobe epilepsy surgery .  Epilepsy and Behavior111   107255   2020.10

     More details

    Publisher:Epilepsy and Behavior  

    DOI: 10.1016/j.yebeh.2020.107255

    Scopus

    PubMed

  • Combined Transcranial-supraorbital and Transconjunctival Approach for Optic Nerve Coloboma with Ophthalmic Dysplasia Associated with Rheumatoid Arthritis .    7 ( 1 ) 1 - 4   2020.1Combined Transcranial-supraorbital and Transconjunctival Approach for Optic Nerve Coloboma with Ophthalmic Dysplasia Associated with Rheumatoid Arthritis

  • Hasegawa M, Hatayama T, Kondo A, Nagahiro S, Fujimaki T, Amagasaki K, Arita K, Date I, Fujii Y, Goto T, Hanaya R, Higuchi Y, Hongo K, Inoue T, Kasuya H, Kayama T, Kawashima M, Kohmura E, Maehara T, Matsushima T, Mizobuchi Y, Morita A, Nishizawa S, Noro S, Saito S, Shimano H, Shirane R, Takeshima H, Tanaka Y, Tanabe H, Toda H, Yamakami I, Nishiyama Y, Ohba S, Hirose Y, Suzuki T .  Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events .  World Neurosurgery130   e251 - e258   2019.10Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse EventsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Fujio S, Takajo T, Kinoshita Y, Hanaya R, Arimura H, Sugata J, Sugata S, Bohara M, Hiraki T, Yoshimoto K, Arita K .  Sellar Xanthogranuloma: A Quest Based on Nine Cases Assessed with an Anterior Pituitary Provocation Test .  World Neurosurgery130   e150 - e159   2019.10Sellar Xanthogranuloma: A Quest Based on Nine Cases Assessed with an Anterior Pituitary Provocation TestReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Katagiri M, Iida K, Ishihara K, Nair D, Harada K, Kagawa K, Seyama G, Hashizume A, Kuramoto T, Hanaya R, Arita K, Kurisu K .  Anti-seizure effect and neuronal activity change in the genetic-epileptic model rat with acute and chronic vagus nerve stimulation .  Epilepsy Research155   106159   2019.9Anti-seizure effect and neuronal activity change in the genetic-epileptic model rat with acute and chronic vagus nerve stimulationReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Kashida Y, Usui N, Matsuda K, Terada K, Baba K, Kondo A, Hirozawa D, Tottori T, Mihara T, Hanaya R, Arita K, Inoue Y .  Is additional mesial temporal resection necessary for intractable epilepsy with cavernous malformations in the temporal neocortex? .  Epilepsy and Behavior92   145 - 153   2019.3Is additional mesial temporal resection necessary for intractable epilepsy with cavernous malformations in the temporal neocortex?Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Karki P, Yamagami M, Takasaki K, Bohara M, Hosoyama H, Hanada T, Yamasaki F, Hanaya R, Arita K. .  Microvascular Decompression in Patients Aged 30 Years or Younger .  Asian J Neurosurg14 ( 1 ) 111 - 117   2019.3Microvascular Decompression in Patients Aged 30 Years or YoungerReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Komasaku Soichiro, Hanaya Ryosuke, Yonenaga Masanori, Kubo Fumikatsu, Eiraku Naoto, Yamasaki Fumiyuki, Arita Kazunori, Yoshimoto Koji .  Symptomatic Developmental Venous Anomaly with an Increased β2-microglobulin Level in Cerebrospinal Fluid: A Case Report .  Hiroshima Journal of Medical Sciences68 ( 1 ) 13 - 18   2019.3Symptomatic Developmental Venous Anomaly with an Increased β2-microglobulin Level in Cerebrospinal Fluid: A Case Report

     More details

    Publisher:広島大学医学出版会  

    症例は56歳女性で、構音障害を主訴とし、拡散強調画像(DWI)により、右前頭葉病変周囲に高強度領域が描出された。虚血性脳血管障害として治療を行ったところ、3日で症状の鎮静が得られたが、7日後のMRI検査で高強度領域の拡大が観察された。また、ガドリニウム(Gd)造影MRIでは、延髄細静脈に異常に大きな静脈が描出され、髄液中β2-ミクログロブリン(β2MG)濃度は2061μg/ lにまで上昇した。悪性腫瘍との鑑別を要したが、術後23日目のMRIにより、病変部の完全消失とDWI上での高輝度領域減少が認められたことから、本例に観察された発生学的静脈形成異常(DVA)は灌流障害による症候性と判断された。

  • 上笹 貫太郎, 花田 朋子, 花谷 亮典, 霧島 茉莉, 谷本 昭英, 坂本 泰二 .  角膜混濁と眼痛で発見に至ったcolobomatous cystの1例 .  日本眼科学会雑誌123 ( 1 ) 39 - 44   2019.1角膜混濁と眼痛で発見に至ったcolobomatous cystの1例Reviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 花谷 亮典, 細山 浩史, 佐藤 雅紀, 飯田 幸治 .  てんかん外科のススメ 治療選択を広げるために .  てんかん研究36 ( 3 ) 657 - 662   2019.1てんかん外科のススメ 治療選択を広げるためにInvited

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Karki P, Yamagami M, Takasaki K, Bohara M, Hosoyama H, Hanada T, Yamasaki F, Hanaya R, Arita K .  Microvascular Decompression in Patients Aged 30 Years or Younger. .  Asian journal of neurosurgery14 ( 1 ) 111 - 117   2019.1Microvascular Decompression in Patients Aged 30 Years or Younger.

  • Arifin M.T. .  Hemispherotomy for drug-resistant epilepsy in an Indonesian population .  Epilepsy and Behavior Reports12   100337   2019

     More details

    Publisher:Epilepsy and Behavior Reports  

    DOI: 10.1016/j.ebr.2019.100337

    Scopus

    PubMed

  • 大坪 宏, 石川 そでみ, 鈴木 皓晴, 細山 浩史, 花谷 亮典 .  てんかんはzoneかnetworkか? .  Epilepsy12 ( 2 ) 77 - 82   2018.11てんかんはzoneかnetworkか?Reviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Ono T. .  A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force .  Epilepsia Open3 ( S1 ) 90 - 103   2018.11

     More details

    Publisher:Epilepsia Open  

    DOI: 10.1002/epi4.12260

    Scopus

    PubMed

  • Kashida Y, Niiro M, Maruyama H, Hanaya R .  Cerebral Paragonimiasis With Hemorrhagic Stroke in a Developed Country .  Journal of Stroke and Cerebrovascular Diseases27 ( 10 ) 2648 - 2649   2018.10Cerebral Paragonimiasis With Hemorrhagic Stroke in a Developed CountryReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 花谷 亮典, 細山 浩史, 有田 和徳 .  Synaptic vesicle glycoprotein 2Aとてんかん .  てんかん研究36 ( 1 ) 3 - 16   2018.6Synaptic vesicle glycoprotein 2AとてんかんReviewed

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Hosoyama H, Hanaya R, Otsubo T, Sato M, Kashida Y, Sugata S, Katagiri M, Iida K, Arita K .  Application of Rubber Band with Hooks on Both Ends for Vagus Nerve Stimulator Implantation .  World Neurosurgery111   258 - 260   2018.3Application of Rubber Band with Hooks on Both Ends for Vagus Nerve Stimulator ImplantationReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 花谷 亮典, 榎添 理恵子 .  てんかんの薬物治療と看護 総論 .  Brain Nursing33 ( 12 ) 1161 - 1163   2017.12てんかんの薬物治療と看護 総論Invited

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Nishimuta Y. .  Long-term outcome after endovascular treatment of cavernous sinus dural arteriovenous fistula and a literature review .  Acta Neurochirurgica159 ( 11 ) 2113 - 2122   2017.11

     More details

    Publisher:Acta Neurochirurgica  

    DOI: 10.1007/s00701-017-3336-4

    Scopus

    PubMed

  • Fujio S, Hirano H, Yamashita M, Usui S, Kinoshita Y, Tominaga A, Hanada T, Yamahata H, Tokimura H, Hanaya R, Kurisu K, Arita K .  Preoperative and postoperative pituitary function in patients with tuberculum sellae meningioma: Based on pituitary provocation tests .  Neurologia Medico-Chirurgica57 ( 10 ) 548 - 556   2017.10Preoperative and postoperative pituitary function in patients with tuberculum sellae meningioma: Based on pituitary provocation testsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hosoyama H, Matsuda K, Mihara T, Usui N, Baba K, Inoue Y, Tottori T, Otsubo T, Kashida Y, Iida K, Hirano H, Hanaya R, Arita K .  Long-term outcomes of epilepsy surgery in 85 pediatric patients followed up for over 10 years: A retrospective survey .  Journal of Neurosurgery: Pediatrics19 ( 5 ) 606 - 615   2017.5Long-term outcomes of epilepsy surgery in 85 pediatric patients followed up for over 10 years: A retrospective surveyReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Uchida H. .  Radiologic and histologic features of the T2 hyperintensity rim of meningiomas on magnetic resonance images .  Neuroradiology Journal30 ( 1 ) 48 - 56   2017.2

     More details

    Publisher:Neuroradiology Journal  

    DOI: 10.1177/1971400916678228

    Scopus

    PubMed

  • Yonezawa H, Hirano H, Uchida H, Habu M, Hanaya R, Oyoshi T, Sadamura Y, Hanada T, Tokimura H, Moinuddin F, Arita K .  Efficacy of bevacizumab therapy for unresectable malignant glioma: A retrospective analysis .  Mol Clin Oncol6 ( 1 ) 105   2017.1Efficacy of bevacizumab therapy for unresectable malignant glioma: A retrospective analysisReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hanaya R, Niantiarno FH, Kashida Y, Hosoyama H, Maruyma S, Sugata S, Otsubo T, Tanaka K, Ishii A, Hirose H, Arita K .  Vagus nerve stimulation for generalized epilepsy with febrile seizures plus (GEFS+) accompanying seizures with impaired consciousness. .  Epilepsy & Behavior Case Reports7   16 - 19   2017Vagus nerve stimulation for generalized epilepsy with febrile seizures plus (GEFS+) accompanying seizures with impaired consciousness.

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • FUJIO Shingo, HANAYA Ryosuke, KURISU Kaoru, ARITA Kazunori, HIRANO Hirofumi, YAMASHITA Mami, USUI Satoshi, KINOSHITA Yasuyuki, TOMINAGA Atsushi, HANADA Tomoko, YAMAHATA Hitoshi, TOKIMURA Hiroshi .  Preoperative and Postoperative Pituitary Function in Patients with Tuberculum Sellae Meningioma -Based on Pituitary Provocation Tests- .  Neurologia medico-chirurgica57 ( 10 ) 548 - 556   2017

     More details

    Publisher:一般社団法人 日本脳神経外科学会  

    <p>Given the anatomical proximity of tuberculum sellae meningioma (TSM) to the hypothalamo-pituitary system, pituitary function impairments are of great concern. We retrospectively investigated pituitary function changes following surgery in patients with TSM using pituitary provocation tests (PPTs). Thirty-one patients (27 females and 4 males) with TSM underwent initial transcranial surgery (29 patients) or transsphenoidal surgery (two patients); surgeries were performed carefully to avoid injuring the pituitary stalk. In 24 patients, the PPTs were performed via a triple bolus injection with regular insulin, thyrotropin-releasing hormone (TRH), and luteinizing hormone releasing hormone (LH-RH). Seven patients underwent a quadruple test (growth-hormone-releasing factor, corticotrophin-releasing hormone, TRH, and LH-RH). The preoperative and postoperative target hormone levels of the anterior pituitary were normal in 93.5% and 96.8% of patients, respectively. At least one hormonal axis demonstrated impaired PPT responses in two patients (6.5%) preoperatively and in one patient (3.2%) postoperatively. The growth hormone (GH) response was also well preserved. A compromised GH peak level was only observed in one patient (3.2%) preoperatively. Postoperatively, transient diabetes insipidus and transient hyponatremia were observed in four (12.9%) and eight (25.8%) patients, respectively. No patients needed permanent postoperative hormone replacement. The preoperative pituitary function was well preserved in most patients, including those with large tumors pushing against the pituitary stalk considerably or embedded in it. After careful surgery to avoid damaging the pituitary stalk, pituitary function was preserved. However, transient postoperative hyponatremia occurred in 25.8% of patients; thus, surgeons should pay careful attention to this issue.</p>

    DOI: 10.2176/nmc.oa.2017-0079

    Scopus

    PubMed

  • Maruyama S, Okamoto Y, Toyoshima M, Hanaya R, Kawano Y .  Immunoglobulin A deficiency following treatment with lamotrigine .  Brain and Development38 ( 10 ) 947 - 949   2016.11Immunoglobulin A deficiency following treatment with lamotrigineReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Fujio S, Takano K, Arimura H, Habu M, Bohara M, Hirano H, Hanaya R, Nishio Y, Koriyama C, Kinoshita Y, Arita K .  Treatable glomerular hyperfiltration in patients with active acromegaly .  European Journal of Endocrinology175 ( 4 ) 325 - 333   2016.10Treatable glomerular hyperfiltration in patients with active acromegalyReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 花谷 亮典, 有田 和徳 .  処置・手術編 (11章)眼窩手術 吹き抜け骨折の手術 .  眼科ケア2016秋季増刊   265 - 267   2016.10処置・手術編 (11章)眼窩手術 吹き抜け骨折の手術Invited

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 花谷 亮典, 丸山 慎介, 有田 和徳 .  専門医に求められる最新の知識 小児 小児てんかんに対する手術療法のエビデンス .  脳神経外科速報26 ( 10 ) 1089 - 1096   2016.10専門医に求められる最新の知識 小児 小児てんかんに対する手術療法のエビデンスInvited

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 花谷 亮典, 有田 和徳 .  処置・手術編 (11章)眼窩手術 眼窩腫瘍摘出術 .  眼科ケア2016秋季増刊   260 - 264   2016.10処置・手術編 (11章)眼窩手術 眼窩腫瘍摘出術Invited

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Kashida Y, Otsubo T, Hanaya R, Kodabashi A, Tsumagari N, Sugata S, Hosoyama H, Iida K, Nakamura K, Tokimura H, Fujimoto T, Arita K .  Determination of hemispheric language dominance using functional magnetic resonance imaging and the Shiritori (Japanese word chain) task in patients with epilepsy: Comparison with the Wada test .  Epilepsy Research124   16 - 22   2016.8Determination of hemispheric language dominance using functional magnetic resonance imaging and the Shiritori (Japanese word chain) task in patients with epilepsy: Comparison with the Wada testReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Katagiri M, Iida K, Kagawa K, Hashizume A, Ishikawa N, Hanaya R, Arita K, Kurisu K .  Combined surgical intervention with vagus nerve stimulation following corpus callosotomy in patients with Lennox-Gastaut syndrome .  Acta Neurochirurgica158 ( 5 ) 1005 - 1012   2016.5Combined surgical intervention with vagus nerve stimulation following corpus callosotomy in patients with Lennox-Gastaut syndromeReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hashizume A, Akimitsu T, Iida K, Kagawa K, Katagiri M, Hanaya R, Arita K, Kurisu K .  Novel software for performing leksell stereotactic surgery without the use of printing films: Technical note .  Neurologia Medico-Chirurgica56 ( 4 ) 193 - 197   2016.4Novel software for performing leksell stereotactic surgery without the use of printing films: Technical noteReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hanaya R, Arita K .  The new antiepileptic drugs: Their neuropharmacology and clinical indications .  Neurologia Medico Chirurgica 56 ( 4 ) 205 - 220   2016The new antiepileptic drugs: Their neuropharmacology and clinical indications

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Bohara M, Hirabaru M, Fujio S, Higashi M, Yonezawa H, Karki P, Hanaya R, Hirano H, Tokimura H, Arita K .  Choroid plexus tumors: Experience of 10 cases with special references to adult cases .  Neurologia Medico-Chirurgica55 ( 12 ) 891 - 900   2015.12Choroid plexus tumors: Experience of 10 cases with special references to adult casesReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Karki P, Hirano H, Yamahata H, Fujio S, Yonezawa H, Iida K, Bohara M, Oyoship T, Hanaya R, Arita K .  Solitary cranial langerhans cell histiocytosis: Two case reports .  Hiroshima Journal of Medical Sciences64 ( 4 ) 59 - 63   2015.12Solitary cranial langerhans cell histiocytosis: Two case reportsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 飯田 幸治, 花谷 亮典, 香川 幸太, 片桐 匡弥 .  基本をマスター 脳神経外科手術のスタンダード 側頭葉てんかんの基本的手術 Anterior temporal lobectomyの進め方 .  脳神経外科速報25 ( 5 ) 468 - 474   2015.5基本をマスター 脳神経外科手術のスタンダード 側頭葉てんかんの基本的手術 Anterior temporal lobectomyの進め方

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Kawano H, Hirano H, Yonezawa H, Yunoue S, Yatsushiro K, Ogita M, Hiraki Y, Uchida H, Habu M, Fujio S, Oyoshi T, Bakhtiar Y, Sugata S, Yamahata H, Hanaya R, Tokimura H, Arita K .  Improvement in treatment results of glioblastoma over the last three decades and beneficial factors .  British Journal of Neurosurgery29 ( 2 ) 206 - 212   2015.4Improvement in treatment results of glioblastoma over the last three decades and beneficial factorsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Tokimura H, Sugata S, Yamahata H, Yunoue S, Hanaya R, Arita K .  Intraoperative continuous monitoring of facial motor evoked potentials in acoustic neuroma surgery .  Neurosurgical Review37 ( 4 ) 669 - 676   2014.11Intraoperative continuous monitoring of facial motor evoked potentials in acoustic neuroma surgeryReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Yamahata H, Tokimura H, Hirahara K, Ishii T, Mori M, Hanaya R, Arita K .  Lateral suboccipital retrosigmoid approach with tentorial incision for petroclival meningiomas: Technical note .  Journal of Neurological Surgery, Part B: Skull Base75 ( 4 ) 221 - 224   2014.8Lateral suboccipital retrosigmoid approach with tentorial incision for petroclival meningiomas: Technical noteReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hirano H, Yokoyama S, Yunoue S, Yonezawa H, Yatsushiro K, Yoshioka T, Hanaya R, Tokimura H, Arita K .  MRI T2 hypointensity of metastatic brain tumors from gastric and colonic cancers .  International Journal of Clinical Oncology19 ( 4 ) 643 - 648   2014.8MRI T2 hypointensity of metastatic brain tumors from gastric and colonic cancersReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Awa R, Campos F, Arita K, Sugiyama K, Tominaga A, Kurisu K, Yamasaki F, Karki P, Tokimura H, Fukukura Y, Fujii Y, Hanaya R, Oyoshi T, Hirano H .  Neuroimaging diagnosis of pineal region tumors - Quest for pathognomonic finding of germinoma .  Neuroradiology56 ( 7 ) 525 - 534   2014.7Neuroimaging diagnosis of pineal region tumors - Quest for pathognomonic finding of germinomaReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 花田 朋子, 花谷 亮典, 時村 洋, 有田 和徳 .  腫瘍性疾患 髄膜の腫瘍 原発性黒色腫系腫瘍 悪性黒色腫 .  日本臨床別冊神経症候群III   315 - 317   2014.6腫瘍性疾患 髄膜の腫瘍 原発性黒色腫系腫瘍 悪性黒色腫Reviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Hirano H, Yonezawa H, Yunoue S, Habu M, Uchida H, Yoshioka T, Kishida S, Kishida M, Oyoshi T, Fujio S, Sugata S, Yamahata H, Hanaya R, Arita K .  Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: Evaluative methodology for DAB chromogenic immunostaining .  Brain Tumor Pathology31 ( 2 ) 85 - 93   2014.4Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: Evaluative methodology for DAB chromogenic immunostainingReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Oyoshi T, Fujio S, Bohara M, Hanaya R, Tokimura H, Arita K .  The assessment of relationship between the skull base development and the severity of frontal plagiocephaly after bilateral fronto-orbital advancement in the early life .  Child's Nervous System30 ( 1 ) 155 - 159   2014.1The assessment of relationship between the skull base development and the severity of frontal plagiocephaly after bilateral fronto-orbital advancement in the early lifeReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Kagawa K, Iida K, Kakita A, Katagiri M, Nishimoto T, Hashizume A, Kiura Y, Hanaya R, Sugiyama K, Arihiro K, Arita K, Kurisu K .  Electrocorticographic-histopathologic correlations implying epileptogenicity of dysembryoplastic neuroepithelial tumor .  Neurologia Medico-Chirurgica53 ( 10 ) 676 - 687   2013.10Electrocorticographic-histopathologic correlations implying epileptogenicity of dysembryoplastic neuroepithelial tumorReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Campos F, Fujio S, Sugata S, Tokimura H, Hanaya R, Bohara M, Arita K .  Effect of thrombin concentration on the adhesion strength and clinical application of fibrin glue-soaked sponge .  Neurologia medico-chirurgica (Tokyo)53 ( 1 ) 17 - 20   2013.1Effect of thrombin concentration on the adhesion strength and clinical application of fibrin glue-soaked spongeReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Yan HD, Ishihara K, Seki T, Hanaya R, Kurisu K, Arita K, Serikawa T, Sasa M .  Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca2+ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER) .  Brain Research Bulletin90 ( 1 ) 142 - 148   2013.1Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca2+ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER)Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamahata H, Yunoue S, Tokimura H, Hanaya R, Hirano H, Tokudome M, Karki P, Yonezawa H, Sugata S, Kawahara K, Maruyama I, Arita K .  Immunohistochemical expression of thrombomodulin in vestibular schwannoma .  Brain Tumor Pathology30 ( 1 ) 28 - 33   2013.1Immunohistochemical expression of thrombomodulin in vestibular schwannomaReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 辻 貞俊, 兼本 浩祐, 花谷 亮典, 寺田 清人 .  てんかん治療における合理的併用療法 .  Pharma Medica31 ( 1 ) 118 - 123   2013.1てんかん治療における合理的併用療法

     More details

    Language:Japanese   Publishing type:Research paper (conference, symposium, etc.)  

  • Hanaya R, Okamoto H, Fujimoto A, Ochi A, Go C, Snead CO 3rd, Widjaja E, Chuang SH, Kemp SM, Otsubo H .  Total intravenous anesthesia affecting spike sources of magnetoencephalography in pediatric epilepsy patients: Focal seizures vs. non-focal seizures .  Epilepsy Research105 ( 3 ) 326 - 336   2013Total intravenous anesthesia affecting spike sources of magnetoencephalography in pediatric epilepsy patients: Focal seizures vs. non-focal seizuresReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamahata H, Tokimura H, Hirahara K, Ishii T, Hanada T, Hirano H, Hanaya R, Sugata S, Mamitsuka K, Arita K .  Entry Point to the Sylvian Fissure for the Pterional Transsylvian Approach .  Journal of Neurological Surgery A Cent Eur Neurosurg74 ( 4 ) 228 - 233   2013Entry Point to the Sylvian Fissure for the Pterional Transsylvian ApproachReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Bakhtiar Y, Hanaya R, Tokimura H, Hirano H, Oyoshi T, Fujio S, Bohara M, Arita K .  Genometric survey on magnetic resonance imaging of growth hormone producing pituitary adenoma .  Pituitary17 ( 2 ) 142 - 149   2013Genometric survey on magnetic resonance imaging of growth hormone producing pituitary adenomaReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Fujio S, Tokimura H, Hirano H, Hanaya R, Kubo F, Yunoue S, Bohara M, Kinoshita Y, Tominaga A, Arimura H, Arita K .  Severe growth hormone deficiency is rare in surgically-cured acromegalics .  Pituitary 16 ( 3 ) 326 - 332   2013Severe growth hormone deficiency is rare in surgically-cured acromegalicsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hanada T, Yamahata H, Hanaya R, Kurono Y, Nagano H, Kitajima S, Hiraki T, Arita K .  A patient with sinonasal leiomyoma presenting with exophthalmos: Case report and review of the literature .  Neurology Asia18 ( 3 ) 327 - 330   2013A patient with sinonasal leiomyoma presenting with exophthalmos: Case report and review of the literatureReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hirano H, Yoshioka T, Yunoue S, Fujio S, Yonezawa H, Niiro T, Habu M, Oyoshi T, Sugata S, Kamezawa T, Arimura H, Hanaya R, Tokimura H, Tokudome M, Arita K .  TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6 .  Neuropathology32 ( 6 ) 628 - 637   2012.12TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 山崎文之, 渡邊陽祐, 高安武志, 野坂 亮, 梶原佳則, 花谷亮典, 富永 篤, 杉山一彦, 栗栖 薫 .  大脳のびまん性血流低下を示した小脳性無言症の1例 .  Brain and Nerve64 ( 12 ) 1431 - 1433   2012.12大脳のびまん性血流低下を示した小脳性無言症の1例Reviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Hanaya R, Hosoyama H, Sugata S, Tokudome M, Hirano H, Tokimura H, Kurisu K, Serikawa T, Sasa M, Arita K .  Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizure .  Neuroscience221   12 - 20   2012.9Low distribution of synaptic vesicle protein 2A and synaptotagimin-1 in the cerebral cortex and hippocampus of spontaneously epileptic rats exhibiting both tonic convulsion and absence seizureReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Niiro T, Tokimura H, Hanaya R, Hirano H, Fukukura Y, Sugiyma K, Eguchi K, Kurisu K, Yoshioka H, Arita K .  MRI findings in patients with central neurocytomas with special reference to differential diagnosis from other ventricular tumours near the foramen of Monro .  Journal of Clinical Neuroscience19 ( 5 ) 681 - 689   2012.5MRI findings in patients with central neurocytomas with special reference to differential diagnosis from other ventricular tumours near the foramen of MonroReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Shinsato Y, Hanada T, Kisanuki T, Yonezawa H, Yunoue S, Yoshioka T, Hanaya R, Tokimura H, Hirano H, Arita K .  Primary malignant melanoma in the pineal region treated without chemotherapy .  Surgical Neurology International3   123   2012.1Primary malignant melanoma in the pineal region treated without chemotherapy Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Bakhtiar Y, Yonezawa H, Bohara M, Hanaya R, Okamoto Y, Sugiyama K, Yoshioka T, Arita K .  Posterior fossa immature teratoma in an infant with trisomy 21: A case report and review of the literature .  Surgical Neurology International3   100   2012.1Posterior fossa immature teratoma in an infant with trisomy 21: A case report and review of the literatureReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Kagawa K, Iida K, Katagiri M, Nishimoto T, Hashizume A, Kiura Y, Hanaya R, Arita K, Kurisu K .  Successful treatment of mesial temporal lobe epilepsy with bilateral hippocampal atrophy and false temporal scalp ictal onset: a case report .  Hiroshima Journal of Medical Science61 ( 2 ) 37 - 41   2012.1Successful treatment of mesial temporal lobe epilepsy with bilateral hippocampal atrophy and false temporal scalp ictal onset: a case reportReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Awa R, Hanaya R, Hirano H, Tokimura H, Francia C, Yunoue Y, Kitajima S, Arita K .  Gangliocytoma of the medulla oblongata demonstrating high tracer uptake on positron emission tomography .  Journal of Neurooncology106 ( 1 ) 201 - 202   2012Gangliocytoma of the medulla oblongata demonstrating high tracer uptake on positron emission tomographyReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Fujio S, Tokimura H, Hanaya R, Hirano H, Arita K, Yunoue S, Bohara M, Arimura H, Kinoshita Y, Tominaga A .  Gradual declination of IGF-1 over a year after transsphenoidal adenomectomy of GH producing pituitary adenomas .  Endocrine Journal58 ( 12 ) 1087 - 1091   2011.12Gradual declination of IGF-1 over a year after transsphenoidal adenomectomy of GH producing pituitary adenomasReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hanaya R,Kiura Y,Serikawa T,Kurisu K,Arita K,Sasa M .  Modulation of abnormal synaptic transmission in hippocampal CA3 neurons of spontaneously epileptic rats (SER) by levetiracetam .  Brain Research Bulletin86 ( 56 ) 334 - 339   2011.10Modulation of abnormal synaptic transmission in hippocampal CA3 neurons of spontaneously epileptic rats (SER) by levetiracetamReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamasaki F,Kurisu K,Kajiwara Y,Watanabe Y,Takayasu T,Akiyama Y,Saito T,Hanaya R,Sugiyama K .  Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma .  Neuro Oncology13 ( 7 ) 791 - 891   2011.10Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine gliomaReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Uchida H, Arita K, Yunoue S, Yonezawa H, Shinsato Y, Kawano H, Hirano H, Hanaya R, Tokimura H. .  Role of sonic hedgehog signaling in migration of cell lines established from CD133-positive malignant glioma cells. .  Journal of Neurooncology104 ( 3 ) 697 - 704   2011.9Role of sonic hedgehog signaling in migration of cell lines established from CD133-positive malignant glioma cells.Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Sugata S, Hanaya R, Kumafuji K, Tokudome M, Serikawa T, Kurisu K, Arita K, Sasa M .  Neuroprotective effect of levetiracetam on hippocampal sclerosis-like change in spontaneously epileptic rats .  Brain Research Bulletin86 ( 1-2 ) 36 - 41   2011.8Neuroprotective effect of levetiracetam on hippocampal sclerosis-like change in spontaneously epileptic ratsReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Kinoshita Y, Tominaga A, Arita K, Sugiyama K, Hanaya R, Hama S, Sakoguchi T, Usui S, Kurisu K .  Post-operative hyponatremia in patients with pituitary adenoma: post-operative management with a uniform treatment protocol .  Endocrine Journal58 ( 5 ) 373 - 379   2011.5Post-operative hyponatremia in patients with pituitary adenoma: post-operative management with a uniform treatment protocolReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Karki P, Bohara M, Yonezawa H, Tokimura H, Hirano H, Hanaya H, Arita K .  Cerebellopontine angle endodermal cyst presenting with hemifacial spasm: a case report .  Brain Tumor Pathology28 ( 4 ) 371 - 374   2011.4Cerebellopontine angle endodermal cyst presenting with hemifacial spasm: a case reportReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Bohara M, Hirano H, Tokimura H, Hanaya R, Yonezawa H, Campos F,Sugiyama K, Sugata S, Arita K .  Pineal mixed germ cell tumor with a synchronous sellar lesion in the sixth decade .  Brain Tumor Pathology28 ( 2 ) 163 - 166   2011.4Pineal mixed germ cell tumor with a synchronous sellar lesion in the sixth decadeReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamahata H, Tokimura H, Hanaya R, Tajitsu K, Hirabaru M, Yamagami M, K Arita .  Microvascular decompression for trigeminal neuralgia due to compression by the vertebral artery: Report of 3 cases .  Minimally Invasive Neurosurgery54 ( 2 ) 79 - 82   2011.4Microvascular decompression for trigeminal neuralgia due to compression by the vertebral artery: Report of 3 casesReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Sadamura Y,Sugiyama K,Uchida H,Hanaya R,Eguchi K,Kurisu K,Arita K,Hirano H .  Intracranial Germinoma Presenting With Hemiatrophy- Follow-up Results and Literature Review .  Neurologia Medico-Chirurgica (Tokyo)51 ( 2 ) 148 - 152   2011.2Intracranial Germinoma Presenting With Hemiatrophy- Follow-up Results and Literature ReviewReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Bohara M, Yonezawa H, Hanaya R, Takeshita S, Sumida M, Arita K .  Posterior fossa epidermoid cysts presenting with unusual radiological appearances -Two case reports- .  Neurologia Medico-Chirurgica (Tokyo)51 ( 1 ) 85 - 88   2011.1Posterior fossa epidermoid cysts presenting with unusual radiological appearances -Two case reports-Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Shirozu H, Iida K, Hashizumea A, Hanaya R, Kiura Y, Kurisu K, Arita K, Otsubo H .  Gradient magnetic-field topography reflecting cortical activities of neocortical epilepsy spikes. .  Epilepsy Research90 ( 42006 ) 121 - 131   2010.6Gradient magnetic-field topography reflecting cortical activities of neocortical epilepsy spikes.Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Arita K, Tokimura H, Hanaya R, Sugata S, Akimitsu T, Iida K, Sugiyama K, Kurisu K .  Hypothalamic hamartoma: Pathophysiology and treatment .  Japanese Journal of Neurosurgery19 ( 4 ) 296 - 303   2010.4Hypothalamic hamartoma: Pathophysiology and treatmentReviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Scopus

  • 藤尾 信吾,平野 宏文,川野 弘人,花谷 亮典,大吉 達樹,新納 正毅,有田 和徳 .  小児の第四脳室に発生した脈絡叢乳頭腫の3例 .  脳神経外科38 ( 2 ) 149 - 155   2010.2小児の第四脳室に発生した脈絡叢乳頭腫の3例Reviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Fumiyuki Yamasaki,Kazuhiko Sugiyama,Megu Ohtaki,Yukio Takeshima,Nobukazu Abe,Yuuj,Akiyama,Junko Takaba,Vishwa Jeet Amatya,Taiichi Saito,Yoshinori Kajiwara,Ryosuke Hanaya,Kaoru Kurisu .  Glioblastoma treated with postoperative radio-chemotherapy: Prognostic value of apparent diffusion coefficient at MR imaging .  European Journal of Radiology73 ( 3 ) 532 - 537   2010Glioblastoma treated with postoperative radio-chemotherapy: Prognostic value of apparent diffusion coefficient at MR imagingReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hiroshi Shirozu, Koji Iida, Akira Hashizume, Ryosuke Hanaya, Yoshihiro Kiura, Kaoru Kurisu, Kazunori Arita, Hiroshi Otsubo .  Gradient magnetic-field topography reflecting cortical activities of neocortical epilepsy spikes. .  Epilepsy Research90 ( 1-2 ) 121 - 131   2010Gradient magnetic-field topography reflecting cortical activities of neocortical epilepsy spikes.Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Ryosuke Hanaya, Masashi Sasa, Sei Sugata, Mai Tokudome, Tadao Serikawa, Kaoru Kurisu, Kazunori Arita .  Hippocampal cell loss and propagation of abnormal discharges accompanied with the expression of tonic convulsion in the spontaneously epileptic rat .  Brain Research1328   171 - 180   2010Hippocampal cell loss and propagation of abnormal discharges accompanied with the expression of tonic convulsion in the spontaneously epileptic ratReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • 花谷亮典、時村 洋、平野宏文、山崎文之、杉山一彦、栗栖 薫、有田和徳 .  松果体近傍腫瘍に対する後頭経テント接近法における最近の工夫 .  脳腫瘍の外科 2010   228 - 233   2010松果体近傍腫瘍に対する後頭経テント接近法における最近の工夫Reviewed

     More details

    Language:Japanese   Publishing type:Research paper (other academic)  

  • 橋本尚美,山根冠児,沖井則文,石之神小織,恩田秀賢,田路浩正,花谷亮典 .  自家血硬膜外注入療法後に昏睡を伴う慢性硬膜下血腫を生じた特発性脳脊髄液減少症例 .  脳神経外科ジャーナル18 ( 7 ) 525 - 530   2009.7自家血硬膜外注入療法後に昏睡を伴う慢性硬膜下血腫を生じた特発性脳脊髄液減少症例Reviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Hanaya R,Koning E,Ferrandon A,Nehlig A .  The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic rats .  Neurobiology of Disease31 ( 3 ) 451 - 458   2008.9The role of the inherited genetic background on the consequences of lithium-pilocarpine status epilepticus: study in Genetic Absence Epilepsy Rats from Strasbourg and Wistar audiogenic ratsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Doskaliyev A,Yamasaki F,Kenjo M,Shrestha P,Saito T,Hanaya R,Sugiyama K,Kurisu K .  Secondary anaplastic oligodendroglioma after cranial irradiation: a case report .  Journal of Neuro-oncology88 ( 3 ) 299 - 303   2008.7Secondary anaplastic oligodendroglioma after cranial irradiation: a case reportReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hanaya R,Koning E,Ferrandon A,Schweitzer A,Andrieux A,Nehlig A .  The deletion of the STOP gene, a microtuble stabilizing factor, leads only to discrete cerebral metabolic changes in mice .  Journal of Neuroscience Research83 ( 4 ) 813 - 820   2008.3The deletion of the STOP gene, a microtuble stabilizing factor, leads only to discrete cerebral metabolic changes in miceReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hanaya R,Kiura Y,Kurisu K,Sakai N,Serikawa T,Sasa M .  N-acetyl-L-aspartate activates hippocampal CA3 neurons in rodent slice preparations .  Brain Research Bulletin75 ( 5 ) 663 - 667   2008.3N-acetyl-L-aspartate activates hippocampal CA3 neurons in rodent slice preparationsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Okazaki T, Magaki T, Takeda M, Kajiwara Y, Hanaya R, Sugiyama K, Arita K, Nishimura M, Kato Y, Kurisu .  Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats .  Neuroscience Letter430 ( 2 ) 109 - 114   2008.1Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in ratsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Shibukawa M,Hanaya R,Ito Y,Wakasa T,Arita K,Kurisu K .  Treatment of Meningioma in a Patient with Congenital Immunodeficiency Disorder .  Hiroshima Journal of Medical Science56 ( 42067 ) 41 - 44   2007.12Treatment of Meningioma in a Patient with Congenital Immunodeficiency DisorderReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hashizume A, Kurisu K, Iida K, Hanaya R, Shirozu H, Otsubo H .  Comparison of animated spatial filtered MEG data for epileptic discharges .  International Congress Series1300   641 - 644   2007.6Comparison of animated spatial filtered MEG data for epileptic dischargesReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hashizume A, Iida K, Shirozu H, Hanaya R, Kiura Y, Kurisu K, Otsubo H .  Gradient magnetic-field topography for dynamic changes of epileptic discharges .  Brain Research1144   175 - 179   2007.5Gradient magnetic-field topography for dynamic changes of epileptic dischargesReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Yan HD,Ishihara K,Hanaya R,Kurisu K,Serikawa T,Sasa M .  Voltage-dependent Calcium Channel Abnormalities in Hippocampal CA3 Neurons of Spontaneously Epileptic Rats .  Epilepsia48 ( 4 ) 758 - 764   2007.4Voltage-dependent Calcium Channel Abnormalities in Hippocampal CA3 Neurons of Spontaneously Epileptic RatsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hanaya R,Boehm N,Nehlig A .  Dissociation of the immunoreactivity of synaptophysin and GAP-43 in the lithium-pilocarpine model of epilepsy in the immature and adult rat .  Experimenta neurology204 ( 2 ) 720 - 732   2007.4Dissociation of the immunoreactivity of synaptophysin and GAP-43 in the lithium-pilocarpine model of epilepsy in the immature and adult ratReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hashizume A, Shrestha P, Arita K, Sugiyama K, Iida K, Hanaya R, Kiura Y, Yamasaki F, Shirozu H, Kurisu K .  Functional brain mapping and localizing epileptic zone with magnetencephalography: a review of two cases with illustrations .  Nepal Journal of Neuroscience4   106 - 109   2007.1Functional brain mapping and localizing epileptic zone with magnetencephalography: a review of two cases with illustrationsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Hanaya R,Arita K,Itoh Y,Kiura Y,Iida K,Kurisu K .  Zygomatic osteotomy for resection of cavernous angioma in dominant hemispheric temporal lobe .  Hiroshima Journal of Medical Science55 ( 1 ) 39 - 43   2006.3Zygomatic osteotomy for resection of cavernous angioma in dominant hemispheric temporal lobeReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamasaki F, Kurisu K, Satoh K, Arita K, Sugiyama K, Ohtaki M, Takaba J, Tominaga A, Hanaya R, Yoshioka H, Hama S, Ito Y, Kajiwara Y, Yahara K, Saito T, Thohar MA .  Apparent diffusion coefficient of human brain tumors at MR imaging .  Radiology235 ( 3 ) 985 - 991   2005.1Apparent diffusion coefficient of human brain tumors at MR imagingReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 有田 和徳, 栗栖 薫, 杉山 一彦, 富永 篤, 江口 国輝, 飯田 幸治, 花谷 亮典, 魚住 徹 .  合併症の推移から見た,末端肥大症におけるConsensus Meeting Criteria of Cure"の意義" .  日本内分泌学会雑誌79 ( Supple ) 48 - 49   2003.8合併症の推移から見た,末端肥大症におけるConsensus Meeting Criteria of Cure"の意義"Reviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Yamasaki F, Kurisu K, Arita K, Yamanaka M, Ohba S, Hanaya R, Shibukawa M, Kiura Y, Sakamoto S, Okazaki T, Takaba J, Abe N .  Contrast enhanced fast fluid-attenuated inversion-recovery MR imaging for diagnosing cerebral venous angioma: Report of two cases .  Brain and Nerve55 ( 6 ) 537 - 541   2003.6Contrast enhanced fast fluid-attenuated inversion-recovery MR imaging for diagnosing cerebral venous angioma: Report of two casesReviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Scopus

  • Kiura Y, Hanaya R, Serikawa T, Kurisu K, Sakai N, Sasa M .  Involvement of Ca2+channels in abnormal excitability of hippocampal CA3 pyramidal cells in noda epileptic rats .  Journal Pharmacological Sciences91 ( 2 ) 137 - 144   2003.2Involvement of Ca2+channels in abnormal excitability of hippocampal CA3 pyramidal cells in noda epileptic ratsReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 笹 征史, 花谷 亮典 .  薬物とニューロン 抗てんかん薬の作用メカニズムを中心に .  臨床神経生理学31 ( 1 ) 13 - 19   2003.2薬物とニューロン 抗てんかん薬の作用メカニズムを中心に

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Hashizume A, Kurisu K, Arita K, Hanaya R .  Development of magnetoencephalography-magnetic resonance imaging integration software - Technical note .  Neurologia Medico-Chirurgica42 ( 10 ) 455 - 457   2002.10Development of magnetoencephalography-magnetic resonance imaging integration software - Technical noteReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hanaya R, Sasa M, Kiura Y, Ishihara K, Serikawa T, Kurisu K .  Epileptiform burst discharges in hippocampal CA3 neurons of young but not mature Noda epileptic rats (NER) .  Brain Research950 ( 1-2 ) 317 - 320   2002.9Epileptiform burst discharges in hippocampal CA3 neurons of young but not mature Noda epileptic rats (NER)Reviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hanaya R, Sasa M, Kiura Y, Serikawa T, Kurisu K .  Effects of vigabatrin on epileptiform abnormal discharges in hippocampal CA3 neurons of spontaneously epileptic rats (SER) .  Epilepsy Research50 ( 3 ) 223 - 231   2002.8Effects of vigabatrin on epileptiform abnormal discharges in hippocampal CA3 neurons of spontaneously epileptic rats (SER)Reviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 笹 征史, 花谷 亮典 .  薬物とニューロン 抗てんかん薬の作用メカニズムを中心に .  日本薬物脳波学会雑誌4 ( 1 ) 48 - 51   2002.7薬物とニューロン 抗てんかん薬の作用メカニズムを中心に

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Sugiyama K, Arita K, Tominaga A, Hanaya R, Taniguchi E, Okamura T, Itoh Y, Yamasaki F, Kurisu K .  Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning. .  Brain tumor pathology18 ( 2 ) 115 - 122   2001Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning.Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Arita K, Kurisu K, Iida K, Hanaya R, Sugiyama K, Akimitsu T, Takeshita S, Kiura Y .  Surgical treatment for intractable epilepsy caused by cavernous angioma in the temporal lobe of the dominant hemisphere .  Neurologia Medico-Chirurgica40 ( 8 ) 439 - 445   2000.8Surgical treatment for intractable epilepsy caused by cavernous angioma in the temporal lobe of the dominant hemisphereReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 笹 征史, 秋光 知英, 花谷 亮典, 栗栖 薫 .  てんかんの基礎研究 Noda epileptic rat(NER)の特徴 .  医学のあゆみ193 ( 6 ) 511 - 514   2000.5てんかんの基礎研究 Noda epileptic rat(NER)の特徴

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Akimitsu T, Kurisu K, Hanaya R, Iida K, Kiura Y, Arita K, Matsubayashi H, Ishihara K, Kitada K, Serikawa T, Sasa M .  Epileptic seizures induced by N-acetyl-L-aspartate in rats: In vivo and in vitro studies .  Brain Research861 ( 1 ) 143 - 150   2000.4Epileptic seizures induced by N-acetyl-L-aspartate in rats: In vivo and in vitro studiesReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 有田 和徳, 栗栖 薫, 富永 篤, 杉山 一彦, 井川 房夫, 花谷 亮典, 飯田 幸治, 魚住 徹 .  機能性腺腫の治癒基準と長期治療予後 GH産生下垂体腺腫各種緩解基準の臨床的意義 長期追跡の結果から .  ホルモンと臨床47   27 - 30   1999.12機能性腺腫の治癒基準と長期治療予後 GH産生下垂体腺腫各種緩解基準の臨床的意義 長期追跡の結果からReviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 有田 和徳, 栗栖 薫, 富永 篤, 花谷 亮典, 飯田 幸治, 江口 国輝, 川本 仁志, 溝上 達也, 魚住 徹 .  残存・再発下垂体腺腫に対する治療 成長ホルモン産生下垂体腺腫の術後残存と再発の管理 長期追跡の結果から .  ホルモンと臨床46 ( 特別増刊 ) 51 - 54   1998.12残存・再発下垂体腺腫に対する治療 成長ホルモン産生下垂体腺腫の術後残存と再発の管理 長期追跡の結果からReviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 笹 征史, 石原 熊寿, 松林 弘明, 花谷 亮典, 飯田 幸治, 秋光 知英, 芹川 忠夫, 栗栖 薫 .  てんかんの基礎 .  神経研究の進歩42 ( 6 ) 947 - 953   1998.10てんかんの基礎

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Arita K, Kurisu K, Iida K, Hanaya R, Akimitsu T, Hibino S, Pant B, Hamasaki M, Shinagawa S .  Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case report .  Journal of Neurosurgery89 ( 4 ) 645 - 648   1998.10Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case reportReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Iida K, Sasa M, Serikawa T, Noda A, Ishihara K, Akimitsu T, Hanaya R, Arita K, Kurisu K .  Induction of convulsive seizures by acoustic priming in a new genetically defined model of epilepsy (Noda epileptic rat: NER) .  Epilepsy Research30 ( 2 ) 115 - 126   1998.4Induction of convulsive seizures by acoustic priming in a new genetically defined model of epilepsy (Noda epileptic rat: NER)Reviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hanaya R, Sasa M, Ujihara H, Ishihara K, Serikawa T, Iida K, Akimitsu T, Arita K, Kurisu K .  Suppression by topiramate of epileptiform burst discharges in hippocampal CA3 neurons of spontaneously epileptic rat in vitro .  Brain Research789 ( 2 ) 274 - 282   1998.4Suppression by topiramate of epileptiform burst discharges in hippocampal CA3 neurons of spontaneously epileptic rat in vitroReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Yoshioka H, Sakoda K, Kohno H, Hada H, Hanaya R, Arita K, Kurisu K .  A case of neurofibromatosis type I associated with basal meningocele and abnormal vessel .  Brain and Nerve50 ( 3 ) 279 - 283   1998.3A case of neurofibromatosis type I associated with basal meningocele and abnormal vesselReviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hanaya R, Sasa M, Ishihara K, Akimitsu T, Iida K, Amano T, Serikawa T, Arita K, Kurisu K .  Antiepileptic effects of 20-hydroxyecdysone on convulsive seizures in spontaneously epileptic rats .  Japanese Journal of Pharmacology74 ( 4 ) 331 - 335   1997.8Antiepileptic effects of 20-hydroxyecdysone on convulsive seizures in spontaneously epileptic ratsReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • Sasa M, Hanaya R, Iida K, Akimitsu T, Kurisu K, Noda A, Serikawa T .  A novel epilepsy animal model (NER) .  Japanese Journal of Psychopharmacology17 ( 1 ) 35 - 38   1997.2A novel epilepsy animal model (NER)

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Scopus

  • 有田 和徳, 栗栖 薫, 花谷 亮典, 他 .  成長ホルモン産生下垂体腺腫の術後寛解と再発 経蝶形骨洞手術後5年以上の長期追跡の結果から .  ホルモンと臨床44 ( 春季増刊 ) 62 - 67   1996.3成長ホルモン産生下垂体腺腫の術後寛解と再発 経蝶形骨洞手術後5年以上の長期追跡の結果からReviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 花谷亮典, 五石惇司, 曽我部貴士, 佐藤 斉, 溝上達也 .  産褥期に生じた皮質盲の1例 .  日本救急医学会雑誌7 ( 2 ) 76 - 80   1996.2産褥期に生じた皮質盲の1例Reviewed

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Sasa M, Amano T, Matsubayashi H, Ishihara, K, Iida K, Hanaya R, Fujita Y, Noda A, Serikawa T .  Evaluation of antiepileptics using epileptic model animals (SER and NER) .  Folia Pharmacologica Japonica108 ( SUPPL. 1 ) 35 - 40   1996Evaluation of antiepileptics using epileptic model animals (SER and NER)Reviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Scopus

  • Hanaya R, Sasa M, Ujihara H, Fujita Y, Amano T, Matsubayashi H, Serikawa T, Uozumi T .  Effect of Antiepileptic Drugs on Absence‐Like Seizures in the Tremor Rat .  Epilepsia36 ( 9 ) 938 - 942   1995.9Effect of Antiepileptic Drugs on Absence‐Like Seizures in the Tremor RatReviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Scopus

  • 花谷亮典, 五石惇司, 曽我部貴士, 佐藤 斉, 溝上達也 .  Ethylene vinyl alcohol copolymer(EVAL)を用いた術中塞栓術を併用し全摘出できた大脳基底核脳動静脈奇形再出血例の経験 .  日赤医学45 ( 3 ) 227 - 230   1993.9Ethylene vinyl alcohol copolymer(EVAL)を用いた術中塞栓術を併用し全摘出できた大脳基底核脳動静脈奇形再出血例の経験Reviewed

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • 三上貴司, 大谷美奈子, 岡林清司, 藤岡泰博, 住田公昭, 城山和久, 岡本太郎, 盛生倫夫, 有田和徳, 河野宏明, 花谷亮典, 魚住 徹 .  重症肺挫傷に対する膜型人工肺(ECLA)の使用経験:肺挫傷合併例における問題点 .  救急医学16 ( 5 ) 605 - 607   1992.5重症肺挫傷に対する膜型人工肺(ECLA)の使用経験:肺挫傷合併例における問題点Reviewed

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Takechi A, Uozumi T, Mukada K, Kurisu K, Arita K, Yano T, Hirohata T, Ogasawara H, Ondo J, Hanaya R, et al .  A case of pituitary adenoma with simultaneous secretion of TSH and GH detected by double immunostaining method .    43 ( 8 ) 775 - 779   1991.8A case of pituitary adenoma with simultaneous secretion of TSH and GH detected by double immunostaining methodReviewed

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Scopus

▼display all

Books

  • 神経救急・脳神経外科周術期におけるてんかん発作の管理 ホスフェニトインによる実践集

    花谷亮典 平野宏文 有田和徳(V 脳腫瘍の周術期管理)

    ライフサイエンス  3015.3 

     More details

    Responsible for pages:180-183   Language:Japanese

  • 臨床てんかん学

    花谷亮典 有田和徳(第10章 検査 B 画像診断 1.脳の形態(CT, MRI))

    医学書院  2015.11 

     More details

    Responsible for pages:302-308   Language:Japanese

  • 臨床てんかん学

    花谷亮典 有田和徳(第13章 てんかん外科手術 D 病態ごとに適した手術術式と手術予後 2.脳内腫瘤を伴う焦点性てんかん)

    医学書院  2015.11 

     More details

    Responsible for pages:564-566   Language:Japanese

  • Neurosurgery Trick of the Trade - Cranial

    Arita K, Hanaya R(Occipital transtentorial approach for pineal region tumor)

    Thieme Medical Publisher, New York  2013.12 

     More details

    Responsible for pages:2019-222   Language:English

  • 脳神経外科 周術期管理の全て

    有田和徳,花谷亮典( Role: Joint author ,  電解質異常)

    メジカルビュー  2009.6 

     More details

    Responsible for pages:518-528   Language:Japanese Book type:Scholarly book

  • GABA: Receptors, Transporters and Metabolism

    Sasa Masashi,Tsujiyama Shuji,Ishihara Kumatoshi,Hanaya Ryosuke,Fujita Meiko,Kurisu Kaoru,Yajin Koji,Serikawa Tadao( Role: Joint author)

    Birkhauser Verlag, Basel, Switzerland   1996 

     More details

    Responsible for pages:185-194   Language:English

▼display all

MISC

  • 【脳神経外科手術:セットアップの基本】手術セットアップ 神経内視鏡手術

    藤尾 信吾, 花谷 亮典

    脳神経外科速報   32 ( 4 )   523 - 529   2022.7

     More details

    Language:Japanese   Publisher:(株)メディカ出版  

  • 【脳波の読み方-up to date】疾患別の脳波 Lennox-Gastaut症候群

    丸山 慎介, 花谷 亮典

    Clinical Neuroscience   40 ( 4 )   483 - 486   2022.4

     More details

    Language:Japanese   Publisher:(株)中外医学社  

  • Wilson病に伴うジストニア重積状態に対する髄腔内バクロフェン投与(ITB:intrathecal baclofen therapy)療法の経験

    花田 朋子, 花谷 亮典, 東 拓一郎, 山中 彩衣, 米衛 ちひろ, 松永 愛香, 丸山 慎介, 吉本 幸司

    日本定位・機能神経外科学会プログラム・抄録集   61回   99 - 99   2022.1

     More details

    Language:Japanese   Publisher:(一社)日本定位・機能神経外科学会  

  • Efficacy of “shared decision making” in surgical treatment for drug-resistant epilepsy: Two case reports

    東拓一郎, 花谷亮典, 佐藤雅紀, 細山浩史, 大坪俊昭, 吉本幸司

    日本てんかん外科学会プログラム・抄録集   45th   2022

     More details

  • A case of juvenile trigeminal neuralgia with psychogenic hearing loss who struggled to decide on surgical intervention

    田中俊一, 花谷亮典, 吉本幸司

    日本脳神経減圧術学会プログラム・抄録集   24th   2022

     More details

  • 脳波の読み方-up to date B.疾患別の脳波 Lennox-Gastaut症候群

    丸山慎介, 花谷亮典

    Clinical Neuroscience   40 ( 4 )   2022

     More details

  • 【グリオーマ-現在の常識と近未来のスタンダード】各種グリオーマの集学的治療戦略 高齢者グリオーマ

    山崎 文之, 高安 武志, 花谷 亮典

    Neurological Surgery   49 ( 3 )   647 - 659   2021.5

     More details

    Language:Japanese   Publisher:(株)医学書院  

    <文献概要>Point ・臓器機能や認知機能の低下に対して高齢者総合機能評価(CGA)を行い,治療強度を適切に調整する.・脆弱(unfit)の高齢者患者に対して寡分割放射線照射やテモゾロミド単独療法などが開発され,非劣性が示された.・高齢者グリオーマに対するてんかん治療では,臓器機能や認知機能と薬物代謝に配慮が必要である.

  • A case of microvascular decompression for a super elder patient with trigeminal neuralgia

    田中俊一, 花谷亮典, 吉本幸司

    日本脳神経減圧術学会プログラム・抄録集   23rd   2021

     More details

  • Our cases of vagus nerve stimulation for drug-resistant epilepsy in children

    39 ( 2 )   2021

     More details

  • Correlation between sleep stage before surgery and seizure outcome after vagus nerve stimulation

    39 ( 2 )   2021

     More details

  • Elderly Glioma

    山崎文之, 高安武志, 花谷亮典

    Neurological Surgery   49 ( 3 )   2021

     More details

  • Surgical treatment of a case of Hemiconvulsion hemiplegia epilepsy syndrome

    39 ( 2 )   2021

     More details

  • Correlation between sleep spindle in electroencephalography and seizure outcome after vagus nerve stimulation

    花谷亮典, 東拓一郎, 東拓一郎, 佐藤雅紀, 細山浩史, 大坪俊昭, 吉本幸司

    日本てんかん外科学会プログラム・抄録集   44th   2020

     More details

  • How to use antiepileptic drugs

    44th   2020

     More details

  • 迷走神経刺激療法の現状と今後の展望

    細山浩史, 花谷亮典, 大坪俊昭, 佐藤雅紀, 泊祐美, 丸山慎介, 米衛ちひろ, 馬場悠生, 有田和徳, 吉本幸司

    日本てんかん外科学会プログラム・抄録集   43rd   2020

     More details

  • Important points of Vagus nerve stimulation implantation

    44th   2020

     More details

  • 離島地域のてんかん外科普及における課題

    花谷亮典, 細山浩史, 佐藤雅紀, 泊祐美, 大坪俊昭, 吉本幸司

    日本てんかん外科学会プログラム・抄録集   43rd   2020

     More details

  • 急性・慢性迷走神経刺激術を行なったNoda Epileptic Ratにおける抗てんかん作用と神経活動変化

    片桐匡弥, 飯田幸治, 石原熊寿, 原田佳奈, 香川幸太, 瀬山剛, 岡村朗健, 橋詰顕, 庫本高志, 花谷亮典, 有田和徳, 栗栖薫

    日本てんかん外科学会プログラム・抄録集   43rd   2020

     More details

  • てんかん重積に対するVNS施行後にPNESを高頻度に合併している左側頭葉てんかん症例

    細山浩史, 花谷亮典, 大坪俊昭, 佐藤雅紀, 樫田祐美, 吉本幸司

    日本てんかん外科学会プログラム・抄録集   43rd   2020

     More details

  • てんかん外科のススメ 治療選択を広げるために

    花谷 亮典, 細山 浩史, 佐藤 雅紀, 飯田 幸治

    てんかん研究   36 ( 3 )   657 - 662   2019.1

     More details

    Publisher:(一社)日本てんかん学会  

  • 捻れた三叉神経の直線化により症状消失に至った三叉神経痛の一例

    細山浩史, 花谷亮典, 有田和徳, 吉本幸司

    日本脳神経減圧術学会プログラム・抄録集   21st   2019

     More details

  • 耳介部痛で発症し三叉神経痛との鑑別に苦慮した舌咽神経痛の一例

    増田圭亮, 細山浩史, 花谷亮典, 吉本幸司

    日本脳神経減圧術学会プログラム・抄録集   22nd   2019

     More details

  • 迷走神経刺激療法の新しい位置付け~てんかん重積に対する効果~

    細山浩史, 花谷亮典, 花谷亮典, 佐藤雅紀, 佐藤雅紀, 大坪俊昭, 樫田祐美, 丸山慎介, 吉本幸司

    日本てんかん外科学会プログラム・抄録集   42nd   2019

     More details

  • The Mechanism of Acute and Chronic Anti-seizure Effect of Vagus Nerve Stimulation in The Genetic-epileptic Model Rat

    片桐匡弥, 飯田幸治, 石原熊寿, 原田佳奈, 香川幸太, 瀬山剛, 岡村朗健, 橋詰顕, 庫本高志, 花谷亮典, 有田和徳, 栗栖薫

    てんかん研究   37 ( 2 )   2019

     More details

  • 作用機序からみる抗てんかん薬

    花谷亮典, 花谷亮典

    日本てんかん外科学会プログラム・抄録集   42nd   2019

     More details

  • 30歳以下の患者に対する神経血管減圧術施行症例の検討

    花谷亮典, KARKI Prasanna, 細山浩史, 有田和徳, 吉本幸司, 山神雅之

    日本脳神経減圧術学会プログラム・抄録集   21st   2019

     More details

  • <sup>11</sup>C-Methionine PETを用いたてんかん原性領域推定と術後発作転帰

    花谷亮典, 大坪俊昭, 細山浩史, 丸山慎介, 佐藤雅紀, 樫田祐美, 有田和徳, 吉本幸司

    日本てんかん外科学会プログラム・抄録集   42nd   2019

     More details

  • FDG-PETの術前所見と側頭葉てんかん焦点切除術前後の神経心理学的変化の関連

    佐藤雅紀, 花谷亮典, 細山浩史, 樫田祐美, 大坪俊昭, 丸山慎介, 吉本幸司

    日本てんかん外科学会プログラム・抄録集   42nd   2019

     More details

  • てんかんはzoneかnetworkか?

    大坪 宏, 石川 そでみ, 鈴木 皓晴, 細山 浩史, 花谷 亮典

    Epilepsy: てんかんの総合学術誌   12 ( 2 )   77 - 82   2018.11

     More details

    Publisher:(株)メディカルレビュー社  

  • Synaptic vesicle glycoprotein 2Aとてんかん

    花谷 亮典, 細山 浩史, 有田 和徳

    てんかん研究   36 ( 1 )   3 - 16   2018.6

     More details

    Publisher:(一社)日本てんかん学会  

    シナプス小胞糖タンパク2A(synaptic vesicle glycoprotein 2A:SV2A)は、シナプス小胞に特異的に発現する膜タンパクで、即時放出可能プールのシナプス前膜への融合、プライミング、synaptotagmin-1との相互作用などの、エキソサイトーシス機構を調節することにより、神経伝達物質の放出を制御すると考えられている。抗てんかん薬レベチラセタム(LEV)がSV2Aに結合することが発見されて以来、SV2Aとてんかん発現との関連が注目されてきた。疾患モデルやヒトでのてんかん研究ではSV2A発現が低下するとの報告が多く、てんかんの発現には抑制系のSV2Aが関連していることが推測される。一方で、LEVの作用機序に関する報告は、LEVが興奮系のSV2Aを介して作用することを示唆する。SV2Aは興奮性と抑制性シナプスの両方に存在し、また実験系や背景疾患などによってSV2A発現に相違があるため、その役割を現時点で明確に特定することは難しい。SV2Aの生理的機構や関連する病態の解明に向けて研究の発展が望まれる。(著者抄録)

  • 【もう慌てないけいれん・てんかん 発作時の対応・治療・日常生活支援までバッチリわかる!】てんかんの薬物治療と看護 総論

    花谷 亮典, 榎添 理恵子

    Brain Nursing   33 ( 12 )   1161 - 1163   2017.12

     More details

    Publisher:(株)メディカ出版  

  • 視床下部過誤腫の病態と治療 Reviewed

    有田 和徳, 時村 洋, 花谷 亮典, 菅田真生, 秋光知英, 飯田 幸治, 杉山一彦, 栗栖 薫

    脳神経外科ジャーナル   19   296 - 303   2010

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Presentations

  • 花谷亮典   年間活動報告  

    第14回国立てんかん外科ネットワーク  第14回国立てんかん外科ネットワーク

     More details

    Event date: 2013.2

    Language:Japanese  

    Venue:東京  

    その他

  • 花谷亮典, 大坪俊昭, 細山浩史, 菅田真生, 中村克己, 藤元登四郎, 飯田幸治, 有田和徳   てんかん外科術前評価における11C-Methionine PETの役割   International conference

    第36回日本てんかん外科学会  第36回日本てんかん外科学会

     More details

    Event date: 2013.1

    Language:English  

    Venue:岡山  

    国際学会

  • 花谷亮典, 田中俊一, 菅田真生, 時村 洋, 有田和徳   顔面けいれんroot exit zone同定における顔面神経刺激の有用性  

    第15回日本脳神経減圧術学会  第15回日本脳神経減圧術学会

     More details

    Event date: 2013.1

    Language:Japanese  

    Venue:岡山  

    国内学会

  • 花谷亮典, 大坪俊昭, 細山浩史, 菅田真生, 新里能成, 湯之上俊二, 中村克巳, 飯田幸治, 藤元登四郎, 有田和徳   てんかん原性領域を超えるFDG-PET低集積部位の評価 (シンポジウム)  

    第71回日本脳神経外科学会  第71回日本脳神経外科学会

     More details

    Event date: 2012.10

    Language:Japanese  

    Venue:大阪  

    国内学会

  • 花谷亮典, 細山浩史, 菅田真生, 大坪俊昭, 藤元登四郎, 飯田幸治, 有田和徳   難治性新皮質てんかんにおける発作間歇期FDG-PET集積低下とSV2A発現低下との関連性  

    第46回日本てんかん学会  第46回日本てんかん学会

     More details

    Event date: 2012.10

    Language:Japanese  

    Venue:東京  

    国内学会

  • 花谷亮典, 久保文克, 米澤 大, ユーリツ・バクティアル, 内田裕之, 山畑仁志, 平野宏文, 時村 洋, 有田 和   側脳室・第3脳室近傍腫瘍手術における術中MRIの有用性  

    第17回脳腫瘍の外科学会  第17回脳腫瘍の外科学会

     More details

    Event date: 2012.9

    Language:Japanese  

    Venue:横浜  

    国内学会

  • 花谷亮典 大坪俊昭 細山浩史 菅田真生 高田橋篤史 藤元登四郎 有田和徳   小児てんかん外科術前評価における鎮静薬の影響  

    第37回鹿児島てんかん研究会  第37回鹿児島てんかん研究会

     More details

    Event date: 2012.7

    Language:Japanese  

    Venue:鹿児島  

    研究会

  • 花谷亮典, 大坪俊昭, 細山浩史, 菅田真生, 高田橋篤史, 藤元登四郎, 有田和徳   難治性てんかん患児の脳磁図検査におけるチアミラールの影響  

    第7回日本てんかん学会九州地方会  第7回日本てんかん学会九州地方会

     More details

    Event date: 2012.6

    Language:Japanese  

    Venue:大分  

    国内学会

  • 花谷亮典, 細山浩史, 菅田真生, 大坪俊昭, 藤元登四郎, 飯田幸治, 笹 征史, 有田和徳   新皮質てんかんにおけるシナプス小胞放出機構障害:外科切除組織による検討  

    第35回日本てんかん外科学会  第35回日本てんかん外科学会

     More details

    Event date: 2012.1

    Language:Japanese  

    Venue:東京  

    国内学会

  • 花谷亮典, 花田朋子, 時村 洋, 西郷輝彦, 有田和徳   責任血管が上錐体静脈上面をまわりこみ走行した三叉神経痛の2症例  

    第14回日本脳神経減圧術学会  第14回日本脳神経減圧術学会

     More details

    Event date: 2012.1

    Language:Japanese  

    Venue:東京  

    国内学会

  • 花谷亮典, 大坪俊昭, 細山浩史, 菅田真生, 飯田幸治, 藤元登四郎, 有田和徳   難治性内側側頭葉てんかんの診断治療におけるFCD‐PETの有用性-ECD‐/IMP‐/IMZ‐SPECTとの比較による検討- (シンポジウム)  

    第70回日本脳神経外科学会  第70回日本脳神経外科学会

     More details

    Event date: 2011.10

    Language:Japanese  

    Venue:横浜  

    国内学会

  • 花谷亮典   完全静脈麻酔が小児てんかん患者の脳磁図に及ぼす影響;局在関連性と非局在関連性てんかんとの比較  

    第45回日本てんかん学会  第45回日本てんかん学会

     More details

    Event date: 2011.10

    Language:Japanese  

    Venue:新潟  

    国内学会

  • 花谷亮典, 八代一孝, 山畑仁志, 菅田真生, 内田裕之, 東 拓一郎, 江口国輝, 時村 洋, 栗栖 薫, 有田和   脳幹海綿状血管腫に対するアプローチ選択  

    第16回日本脳腫瘍の外科学会  第16回日本脳腫瘍の外科学会

     More details

    Event date: 2011.9

    Language:Japanese  

    Venue:横浜  

    国内学会

  • Ryosuke Hanaya   Result of surgery and rehabilitation after epilepsy surgery   International conference

    Workshop on the developing epilepsy surgery team at teaching hospital  Workshop on the developing epilepsy surgery team at teaching hospital

     More details

    Event date: 2010.8

    Language:English  

    Venue:インドネシア  

    国際学会

  • Ryosuke Hanaya   Result of surgery and After epilepsy surgery   International conference

    Epilepsy Surgery Lecture in Jakarta  Epilepsy Surgery Lecture in Jakarta

     More details

    Event date: 2010.8

    Language:English  

    Venue:インドネシア  

    国際学会

  • 花谷亮典 米澤 大 新納忠明 湯之上俊二 平野宏文 時村 洋 有田和徳   脳機能温存のための覚醒下手術   International conference

    第27回鹿児島高次脳機能研究会  第27回鹿児島高次脳機能研究会

     More details

    Event date: 2010.4

    Language:English  

    Venue:鹿児島  

    国際学会

  • 花谷亮典   てんかん外科のエビデンス  

    ラミクタール発売記念発表会  ラミクタール発売記念発表会

     More details

    Event date: 2010.3

    Language:Japanese  

    Venue:鹿児島  

    国内学会

  • 花谷亮典 菅田真生 大坪俊昭 西本武史 香川幸太 飯田幸治 中村克巳 藤元登四郎 栗栖 薫 有田和徳   難治性内側側頭葉てんかんにおける知能指成分の特徴  

    第33回日本てんかん外科学会  第33回日本てんかん外科学会

     More details

    Event date: 2010.1

    Language:Japanese  

    Venue:東京  

    国内学会

  • 花谷亮典 菅田真生 大坪俊昭 山田康一郎 香川幸太 飯田幸治 中村克巳 藤元登四郎 栗栖 薫 有田和徳   難治性内側側頭葉てんかん患者にみられる知能指数低下要因の検討  

    第43回日本てんかん学会  第43回日本てんかん学会

     More details

    Event date: 2009.10

    Language:Japanese  

    Venue:弘前  

    国内学会

  • 花谷亮典 山崎文之 武田正明 森重水貴 杉山一彦 栗栖 薫 有田和徳   Occipital transtentorial approachにおける同名半盲予防の工夫 -Visual evoked potentialモニタリングの導入-  

    第68回日本脳神経外科学会  第68回日本脳神経外科学会

     More details

    Event date: 2009.10

    Language:Japanese  

    Venue:東京  

    国内学会

  • 花谷亮典 時村 洋 平野宏文 山崎文之 杉山一彦 栗栖 薫 有田和徳   松果体近傍腫瘍に対する後頭葉経テント接近法における最近の工夫  

    第14回脳腫瘍の外科学会  第14回脳腫瘍の外科学会

     More details

    Event date: 2009.9

    Language:Japanese  

    Venue:東京  

    国内学会

  • Ryosuke Hanaya Sei Sugata Toshiaki Otsubo Koji Iida Kaoru Kurisu Kazunori Arita   How should we treat the irritative temporal cortex in mesial temporal lobe epilepsy? Histopathological study.   International conference

    XIV Congress of WFNS  XIV Congress of WFNS

     More details

    Event date: 2009.8

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

  • Ryosuke Hanaya Sei Sugata Toshiaki Otsubo Hiroshii Shirozu Koji Iida Kaoru Kurisu Kazunori Arita   Prognosis after surgical treatment for temporal lobe epilepsy in older patient   International conference

    XIV Congress of WFNS  XIV Congress of WFNS

     More details

    Event date: 2009.8

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

  • Ryosuke Hanaya Fumiyuki Yamasaki Kazuhiko Sugiyama Kaoru Kurisu Kazunori Arita   Postoperative course after first surgical treatment of meningioma in the elderly   International conference

    XIV Congress of WFNS  XIV Congress of WFNS

     More details

    Event date: 2009.8

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

  • 花谷亮典 笹 征史 芹川忠夫 有田和徳   N-Acetyl-L-aspartate (NAA)による神経興奮の誘発  

    第7回鹿児島ニューロフォーラム  第7回鹿児島ニューロフォーラム

     More details

    Event date: 2009.7

    Language:Japanese  

    Venue:鹿児島  

    研究会

  • Ryosuke Hanaya Sei Sugata Toshiaki Otsubo Katsumi Nakamura Toshiro Fujimoto Hiroshii Shirozu Koji Iida Kaoru Kurisu Kazunori Arita   Surgical treatment for mesial temporal lobe epilepsy in older patient   International conference

    The 3rd Asian Epilepsy Surgery Congress  The 3rd Asian Epilepsy Surgery Congress

     More details

    Event date: 2009.6

    Language:English  

    Venue:Osaka  

    国際学会

  • 花谷亮典 大坪俊昭 中村克巳 菅田真生 藤元登四郎 朝倉哲彦 栗栖 薫 有田和徳   迷走神経刺激術後の長期経過観察  

    第4回日本てんかん学会九州地方会  第4回日本てんかん学会九州地方会

     More details

    Event date: 2009.6

    Language:Japanese  

    Venue:久留米  

    国内学会

  • 花谷亮典 菅田真生 大坪俊昭 中村克巳 藤元登四郎 山田康一郎 飯田幸治 有田和徳   内側側頭葉てんかん手術症例における術前ウェックスラー式知能検査の検討  

    第26回鹿児島高次脳機能研究会  第26回鹿児島高次脳機能研究会

     More details

    Event date: 2009.5

    Language:Japanese  

    Venue:鹿児島  

    研究会

  • 花谷亮典 米澤 大 粟 隆志 湯之上俊二 平野宏文 有田和徳   高齢者神経膠芽腫に対するテモゾロマイドの使用経験 (シンポジウム)  

    第22回日本老年脳神経外科学会  第22回日本老年脳神経外科学会

     More details

    Event date: 2009.3

    Language:Japanese  

    Venue:広島  

    国内学会

  • 花谷亮典 山崎文之 杉山一彦 栗栖 薫 有田和徳   高齢者髄膜腫初回手術後の経過 -生命表を用いた生命予後調査- (シンポジウム)  

    第22回日本老年脳神経外科学会  第22回日本老年脳神経外科学会

     More details

    Event date: 2009.3

    Language:Japanese  

    Venue:広島  

    国内学会

  • 花谷亮典 菅田真生 八代一孝 有田和徳 大坪俊昭 中村克巳 朝倉哲彦   施術後15年目における迷走神経刺激術の効果判定  

    第16回九州山口てんかん外科研究会、福岡  第16回九州山口てんかん外科研究会、福岡

     More details

    Event date: 2009.2

    Language:Japanese  

    Venue:福岡  

    研究会

  • 花谷亮典   てんかん外科から学ぶこと  

    Brain Talk研究会  Brain Talk研究会

     More details

    Event date: 2008.12

    Language:Japanese  

    Venue:鹿児島  

    研究会

  • 花谷亮典 菅田真生 有田和徳 大坪俊昭 中村克己 藤元登四郎 白水洋史 岐浦禎展 橋詰 顕 飯田幸治 栗栖薫   年長者に施行した側頭葉てんかん手術例の治療予後  

    第42回日本てんかん学会  第42回日本てんかん学会

     More details

    Event date: 2008.10

    Language:Japanese  

    Venue:東京  

    国内学会

  • 花谷亮典,熊藤健太,菅田真生,有田和徳,栗栖薫,芹川忠夫,笹征史   自然発症てんかんラット海馬の硬化性変化に対するレベチラセタムの抑制作用  

    第42回日本てんかん学会  第42回日本てんかん学会

     More details

    Event date: 2008.10

    Language:Japanese  

    Venue:東京  

    国内学会

  • 花谷亮典   てんかんの治療 -最近の動向ー  

    日本てんかん協会九州支部シンポジウム  日本てんかん協会九州支部シンポジウム

     More details

    Event date: 2008.7

    Language:Japanese  

    Venue:鹿児島  

    その他

  • 花谷亮典,菅田真,有田和徳,大坪俊昭,中村克己,藤元登四郎,白水洋史,橋詰顕,飯田幸治,栗栖薫   難治性てんかんに対する脳梁離断施行症例の検討  

    第33回鹿児島てんかん研究会、  第33回鹿児島てんかん研究会、

     More details

    Event date: 2008.7

    Language:Japanese  

    Venue:鹿児島  

    研究会

  • 花谷亮典,菅田真生,笹征史,芹川忠夫,有田和徳   自然発症てんかんラットを用いた抗てんかん薬の薬効・作用機序評価  

    第6回鹿児島ニューロフォーラム  第6回鹿児島ニューロフォーラム

     More details

    Event date: 2008.7

    Language:Japanese  

    Venue:鹿児島  

    研究会

  • 花谷亮典,菅田真生,有田和徳,大坪俊昭,中村克己,藤元登四郎,白水洋史,岐浦禎展 橋詰顕,飯田幸治,栗栖薫   年長側頭葉てんかん患者に対する手術治療予後の検討  

    第3回日本てんかん学会九州地方会、  第3回日本てんかん学会九州地方会、

     More details

    Event date: 2008.6

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 花谷亮典 菅田真生 大坪俊昭 西本武史 香川幸太 飯田幸治 中村克巳 藤元登四郎 栗栖 薫 有田和徳   難治性内側側頭葉てんかんにおける知能指成分の特徴  

    第33回日本てんかん外科学会  第33回日本てんかん外科学会

     More details

    Event date: 2008.1

    Language:Japanese  

    Venue:東京  

    国内学会

  • Ryosuke Hanaya,Masashi Sasa,Kenta Kumafuji,Tadao Serikawa,Kaoru Kurisu   Neuroprotective effect of levetiracetam in spontaneously epileptic rats (SER)   International conference

    61th Annal meeting of American Epilepsy Society  61th Annal meeting of American Epilepsy Society

     More details

    Event date: 2007.12

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

  • 花谷亮典,笹征史,芹川忠夫,栗栖薫   加令に伴い進行する自然発症てんかんラット海馬の硬化性変化  

    第41回日本てんかん学会  第41回日本てんかん学会

     More details

    Event date: 2007.11

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 花谷亮典,岐浦禎展,笹征史,芹川忠夫,栗栖薫   自然発症てんかんラット海馬の異常興奮性獲得に伴うCA3細胞の減少と苔状線維発芽  

    第40回日本てんかん学会  第40回日本てんかん学会

     More details

    Event date: 2006.9

    Language:Japanese  

    Venue:石川  

    国内学会

  • 花谷亮典,Estelle Koning,Arielle Ferrandon,Annie Schweitzer,Annie Andrieux,Astrid Nehlig   STOP蛋白の欠損により誘導される統合失調症マウスに生じる糖代謝異常  

    第79回日本薬理学会  第79回日本薬理学会

     More details

    Event date: 2006.3

    Language:Japanese  

    Venue:神奈川  

    国内学会

  • 花谷亮典,Estelle Koning,Arielle Ferandon,Astrid Nehlig   リチウムピロカルピン誘発てんかん形成における欠神発作と聴原性発作の遺伝性素因の役割  

    第39回日本てんかん学会  第39回日本てんかん学会

     More details

    Event date: 2005.10

    Language:Japanese  

    Venue:北海道  

    国内学会

  • Ryosuke Hanaya Nelly Boehm Astrid Nehlig   Synaptophysin immunoreactivity in the lithium-pilocarpine model of temporal lobe epilepsy in adult and immature rats   International conference

    26the International Epilepsy Congress  26the International Epilepsy Congress

     More details

    Event date: 2005.8

    Language:English  

    Venue:フランス  

    国際学会

  • 細山 浩史, 花谷 亮典, 川原 隆, 厚地 正道, 高崎 孝二, 有田 和徳, 吉本 幸司   高齢発症てんかんの臨床的特徴と診断  

    てんかん研究  2019.9  (一社)日本てんかん学会

  • 花谷 亮典, 大坪 俊昭, 細山 浩史, 樫田 祐美, 丸山 慎介, 中村 克己, 藤元 登四郎, 有田 和徳   頭皮脳波所見と画像所見との解離がみられた内側側頭葉てんかん  

    てんかん研究  2017.1  (一社)日本てんかん学会

  • 細山 浩史, 花谷 亮典, 大坪 俊昭, 津曲 倫子, 樫田 祐美, 菅田 真生, 丸山 慎介, 佐藤 雅紀, 中村 克己, 藤元 登四郎, 有田 和徳   難治性側頭葉てんかん患者における術前から術後2年までのIQ・記銘力の変遷  

    てんかん研究  2017.9  (一社)日本てんかん学会

  • 佐藤 雅紀, 花谷 亮典, 東 拓一郎, 細山 浩史, 丸山 慎介, 米衛 ちひろ, 大坪 俊昭, 吉本 幸司   重度知的障害を伴う薬剤抵抗性てんかん患者に対する成人期でのVNS導入  

    てんかん研究  2020.9  (一社)日本てんかん学会

  • 片桐 匡弥, 飯田 幸治, 石原 熊寿, 原田 佳奈, 香川 幸太, 瀬山 剛, 岡村 朗健, 橋詰 顕, 庫本 高志, 花谷 亮典, 有田 和徳, 栗栖 薫   遺伝性てんかんモデルラットにおける迷走神経刺激による急性および慢性発作減少効果に関するメカニズム(The Mechanism of Acute and Chronic Anti-seizure Effect of Vagus Nerve Stimulation in The Genetic-epileptic Model Rat)  

    てんかん研究  2019.9  (一社)日本てんかん学会

  • 佐藤 雅紀, 花谷 亮典, 細山 浩史, 大坪 俊昭, 丸山 慎介, 樫田 祐美, 吉本 幸司   迷走神経刺激術によるてんかん重積抑制作用の検討  

    てんかん研究  2018.9  (一社)日本てんかん学会

  • 花谷 亮典, 大坪 俊昭, 細山 浩史, 樫田 祐美, 佐藤 雅紀, 丸山 慎介, 飯田 幸治, 有田 和徳, 吉本 幸司   薬剤抵抗性側頭葉てんかんに対する手術後の抑うつ・不安・気分プロフィール評価  

    てんかん研究  2018.9  (一社)日本てんかん学会

  • 花谷 亮典, 大坪 俊昭, 細山 浩史, 佐藤 雅紀, 樫田 祐美, 丸山 慎介, 飯田 幸治, 津曲 倫子, 藤元 登四郎, 有田 和徳   薬剤抵抗性てんかんに対する外科手術前後における前頭葉遂行機能の変化  

    てんかん研究  2017.9  (一社)日本てんかん学会

  • 大坪 俊昭, 高田橋 篤史, 川添 瑞絵, 車田 真里子, 齋藤 友子, 藤元 登四郎, 花谷 亮典, 細山 浩史, 樫田 祐美, 丸山 慎介, 佐藤 雅紀, 八代 一孝, 有田 和徳   脳磁図の再評価とさらなる発展を目指して 電流双極子によるてんかん波形の解釈 藤元総合病院における脳磁図の現状  

    日本生体磁気学会誌  2018.6  日本生体磁気学会

  • 岩元 博史, 花谷 亮典, 細山 浩史, 佐藤 雅紀, 大坪 俊昭, 岡本 裕嗣, 梅原 藤雄, 吉本 幸司   神経ベーチェット病に併発した内側側頭葉てんかんに対する手術経験  

    てんかん研究  2019.9  (一社)日本てんかん学会

  • 瀬山 剛, 飯田 幸治, 香川 幸太, 片桐 匡弥, 花谷 亮典, 有田 和徳, 栗栖 薫   焦点局在が困難な前頭葉てんかんに対する脳梁離断術の有用性  

    てんかん研究  2018.6  (一社)日本てんかん学会

  • 佐藤 雅紀, 細山 浩史, 丸山 慎介, 大坪 俊昭, 藤元 登四郎, 花谷 亮典, 有田 和徳   海綿状血管腫摘出術後に生じた薬剤抵抗性てんかんに対する外科治療  

    てんかん研究  2018.1  (一社)日本てんかん学会

  • 丸山 慎介, 花谷 亮典, 細山 浩史, 大坪 俊昭, 河野 嘉文, 有田 和徳   早期外科治療を行った限局性皮質異形成の1男児例  

    てんかん研究  2017.1  (一社)日本てんかん学会

  • 細山 浩史, 花谷 亮典, 大坪 俊昭, 樫田 祐美, 丸山 慎介, 佐藤 雅紀, 藤元 登四郎, 有田 和徳   抗てんかん薬内服時と非内服時で側方性が異なった側頭葉てんかんの1例  

    てんかん研究  2017.9  (一社)日本てんかん学会

  • 丸山 慎介, 馬場 悠生, 細山 浩史, 花谷 亮典   当院小児科におけるペランパネル導入例の効果について  

    てんかん研究  2018.9  (一社)日本てんかん学会

  • 馬場 悠生, 米衛 ちひろ, 丸山 慎介, 細山 浩史, 花谷 亮典, 大坪 俊昭, 河野 嘉文   当院での難治性てんかんの小児に対する脳梁離断術の検討  

    日本小児科学会雑誌  2020.8  (公社)日本小児科学会

  • 馬場 悠生, 米衛 ちひろ, 丸山 慎介, 細山 浩史, 花谷 亮典, 大坪 俊昭   当院での小児に対する脳梁離断術の検討  

    てんかん研究  2019.9  (一社)日本てんかん学会

  • 吉国 ひかる, 波野 史典, 松井 宏樹, 成 千代子, 樋渡 千愛, 岡山 英樹, 野口 慶久, 花谷 亮典   当院てんかんセンターにおける検査部の取り組みについて  

    日臨技九州支部医学検査学会  2017.10  日臨技九州支部医学検査学会

  • 花谷 亮典   小児難治性てんかんに対する外科治療  

    日本小児科学会雑誌  2017.12  (公社)日本小児科学会

  • 花田 朋子, 花谷 亮典, 米澤 大, 吉本 幸司   円蓋部髄膜腫術後2年の経過で診断された痙攣性発声障害の1例  

    日本定位・機能神経外科学会プログラム・抄録集  2019.12  (一社)日本定位・機能神経外科学会

  • 馬場 悠生, 丸山 慎介, 細山 浩史, 花谷 亮典, 大坪 俊昭, 有田 和徳, 河野 嘉文   乳児期早期のてんかん外科手術で発作消失した皮質形成異常の2例  

    日本小児科学会雑誌  2017.12  (公社)日本小児科学会

  • 丸山 慎介, 花谷 亮典, 佐藤 雅紀, 細山 浩史, 米衛 ちひろ, 佐野 のぞみ, 大坪 俊昭, 吉本 幸司   てんかん発作群発に対する迷走神経刺激術が奏功した1例  

    てんかん研究  2019.1  (一社)日本てんかん学会

  • 細山 浩史, 花谷 亮典, 大坪 俊昭, 樫田 祐美, 佐藤 雅紀, 丸山 慎介, 有田 和徳, 吉本 幸司   てんかん発作と判断し難い発作に対する診断的治療介入の意義  

    てんかん研究  2018.9  (一社)日本てんかん学会

  • 細山 浩史, 花谷 亮典, 大坪 俊昭, 樫田 祐美, 佐藤 雅紀, 丸山 慎介, 吉本 幸司   てんかん発作と判断し難い発作に対する診断的治療介入  

    てんかん研究  2019.1  (一社)日本てんかん学会

  • 佐藤 雅紀, 細山 浩史, 樫田 祐美, 花谷 亮典, 大坪 俊昭, 丸山 慎介, 有田 和徳   てんかん外科手術前後における就学・就労状況の変化  

    てんかん研究  2017.9  (一社)日本てんかん学会

  • 花谷 亮典, 細山 浩史, 佐藤 雅紀, 馬場 悠生, 米衛 ちひろ, 大坪 俊昭, 吉本 幸司   Wadaテストを用いた記銘優位半球評価による薬剤抵抗性側頭葉てんかんの焦点側と術後転帰の予測  

    てんかん研究  2019.9  (一社)日本てんかん学会

  • 米衛 ちひろ, 丸山 慎介, 東 拓一郎, 大坪 俊昭, 花谷 亮典   Hemiconvulsion hemiplegia epilepsy症候群に対しててんかん外科治療が有効であった1例  

    てんかん研究  2021.7  (一社)日本てんかん学会

     More details

    Language:Japanese  

  • 花田 朋子, 花谷 亮典, 東 拓一郎, 山中 彩衣, 米衛 ちひろ, 松永 愛香, 丸山 慎介, 吉本 幸司   Wilson病に伴うジストニア重積状態に対する髄腔内バクロフェン投与(ITB:intrathecal baclofen therapy)療法の経験  

    日本定位・機能神経外科学会プログラム・抄録集  2022.1  (一社)日本定位・機能神経外科学会

     More details

    Language:Japanese  

  • 丸山 慎介, 米衛 ちひろ, 花谷 亮典, 大坪 宏   睡眠時随伴症と睡眠時てんかんの鑑別に苦慮した1幼児例  

    脳と発達  2021.5  (一社)日本小児神経学会

     More details

    Language:Japanese  

  • 丸山 慎介, 米衛 ちひろ, 馬場 悠生, 東 拓一郎, 佐藤 雅紀, 細山 浩史, 大坪 俊昭, 花谷 亮典   迷走神経刺激療法の小児自験例  

    てんかん研究  2021.7  (一社)日本てんかん学会

     More details

    Language:Japanese  

  • 花谷 亮典, 東 拓一郎, 佐藤 雅紀, 細山 浩史, 米衛 ちひろ, 丸山 慎介, 大坪 俊昭, 吉本 幸司   青年・成人における術前睡眠stageとVNS術後発作転帰との関連  

    てんかん研究  2021.7  (一社)日本てんかん学会

     More details

    Language:Japanese  

▼display all

Research Projects

  • 小児タオパチーに伴うてんかん原性病変におけるてんかん原性獲得機序の解明

    Grant number:19K09460  2019.4 - 2022.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  • 内因性光学的計測法を用いた脳神経手術支援技術の創出

    Grant number:18K19933  2018.6 - 2020.3

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

  • 磁気刺激介入による失語症治療法確立を目的とした臨床的研究

    Grant number:16K10791  2016.4 - 2019.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

  • 難治性てんかんにおけるSV2Aおよびシナプス小胞放出機構障害の検討

    Grant number:24592169  2012.4 - 2015.3

    日本学術振興会  科学研究費助成事業  科学研究費補助金

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

  • ヒトの言語ー運動連関のメカニズムの磁気刺激を用いた解明および機能回復への応用

    Grant number:24591301  2012.4 - 2015.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

  • Web会議、ITカルテシステムを用いた脳神経外科診療・教育ネットワークの形成

    Grant number:23590605  2011.4 - 2014.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    Web会議、ITカルテシステムを用いた脳神経外科診療・教育ネットワークの形成

  • ノダてんかんラット(NER)の発作型同定と発作モニタリング法の確立

    Grant number:14771336  2002.4 - 2004.3

    日本学術振興会  科学研究費助成事業  若手研究(B)

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2700000 ( Direct Cost: \2700000 )

    ノダてんかんラット(NER)の発作型同定と発作モニタリング法の確立

▼display all