Kagoshima University   Center for chronic viral diseases   Researcher

1997.5 - 2000.4

Okamoto M, Hidaka A, Toyama M, Baba M. .  Galectin-3 is involved in HIV-1 expression through NF-κB activation and associated with Tat in latently infected cells .    260   86 - 93   2019.1Reviewed

Baba M, Toyama M, Sakakibara N, Okamoto M, Arima N, Saijo M. .  Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors .  Antivir Chem Chemother.25   83 - 89   2017.12Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitorsReviewed

Olufunmilayo G. Oyero, Masaaki Toyama, Naoki Mitsuhiro, Abdulfatah A. Onifade, Akemi Hidaka, Mika Okamoto, Masanori Baba .  SELECTIVE INHIBITION OF HEPATITIS C VIRUS REPLICATION BY ALPHA-ZAM, A Nigella sativa SEED FORMULATION .  African Journal of Traditional, Complementary and Alternative Medicines13   144 - 148   2016.10SELECTIVE INHIBITION OF HEPATITIS C VIRUS REPLICATION BY ALPHA-ZAM, A Nigella sativa SEED FORMULATIONReviewed International coauthorship

Ito W, Toyama M, Okamoto M, Ikeda M, Watashi K, Wakita T, Hashimoto Y, Baba M. .  Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative. .  Antivir Chem Chemother.24   148 - 154   2016.8Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative.Reviewed

Okamoto M, Hidaka A, Toyama M, Hosoya T, Yamamoto M, Hagiwara M, Baba M. .  Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039. .  Antiviral Research123   1 - 4   2015.11Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039.Reviewed

Sakakibara N, Balboni G, Congiu C, Onnis V, Demizu Y, Misawa T, Kurihara M, Kato Y, Maruyama T, Toyama M, Okamoto M, Baba M. .  Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives. .  Antivir Chem Chemother.24   62 - 71   2015.4Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives.Reviewed International coauthorship

Sakakibara N, Baba M, Okamoto M, Toyama M, Demizu Y, Misawa T, Kurihara M, Irie K, Kato Y, Maruyama T. .  Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives .  Antiviral Chem. Chemother. 24   3 - 18   2015.2Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivativesReviewed

Toyama Masaaki, Aoyama Hiroshi, Mukai Risa, Nakamura Masaharu, Yoshimura Koji, Mika Okamoto, Ohsima Takayuki, Hashimoto Yuichi, Masanori Baba .  A Novel Tetramethylnaphthalene Derivative Selectively Inhibits Adult T-Cell Leukemia (ATL) Cells In Vitro .  Anticancer Research34 ( 4 ) 1771 - 1778   2014.4A Novel Tetramethylnaphthalene Derivative Selectively Inhibits Adult T-Cell Leukemia (ATL) Cells In VitroReviewed

Okamoto Mika, Chono Hideto, Kawano Yasuhiro, Saito Naoki, Tshuda Hiroshi, Inoue Koichi, Kato Ikunoshin, Mineno Junichi, Masanori Baba .  Sustained Inhibition of HIV-1 Replication by Conditional Expression of the E. coli-Derived Endoribonuclease MazF in CD4(+) T cells. .  Human Gene Therapy Methods24   94 - 103   2013.4Sustained Inhibition of HIV-1 Replication by Conditional Expression of the E. coli-Derived Endoribonuclease MazF in CD4(+) T cells.Reviewed

Hamasaki Takayuki, Okamoto Mika, Baba Masanori .  Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction. .    57   1323 - 1331   2013.3Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction.Reviewed

Toyama Masaaki, Hamasaki Takayuki, Uto Tomofymi, Aoyama Hiroshi, Okamoto Mika, Yuichi Hashimoto, Baba Masanori .  Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative. .  Anticancer Research32   2639 - 2645   2012.7Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative.Reviewed

Hamasaki Takayuki, Toyama Masaaki, Aoyama Hiroshi, Yohann White, Okamoto Mika, Arima Naomichi, Hashimoto Yuichi, Baba Masanori .  Selective Inhibition of HTLV-1-infected Cell Proliferation by a Novel Tetramethylnaphthalene Derivative .  Anticancer Research31   2241 - 2247   2011.6Selective Inhibition of HTLV-1-infected Cell Proliferation by a Novel Tetramethylnaphthalene DerivativeReviewed

Aoyama Hiroshi, Sugita Kazuyuki, Nakamura Masahiko, Aoyama Atsushi, Mohammed T.A. Salim, Okamoto Mika, Baba Masanori, Hashimoto Yuichi .  Fused heterocyclic amido compounds as anti-hepatitis C virus agents .  Bioorganic & Medicinal Chemistry Letters 19   2675 - 2687   2011.4Fused heterocyclic amido compounds as anti-hepatitis C virus agentsReviewed

Mohammed T.A. Salim, Aoyama Hiroshi, Sugita Kazuyuki, Watashi Kouichi, Wakita Takaji, Hamasaki Takayuki, Okamoto Mika, Urata Yasuo, Hashimoto Yuichi , Baba Masanori .  Potent and selective inhibition of hepatitis C virus replication by novel phenanthridinone derivatives .  Bioorganic & Medicinal Chemistry Letters 415   714 - 719   2011.1Potent and selective inhibition of hepatitis C virus replication by novel phenanthridinone derivatives Reviewed

Mohammed T.A. Salim, Goto Yukinori, Hamasaki Takayuki, Okamoto Mika, Aoyama Hiroshi, Hashimoto Yuichi, Simone Musiu, Jan Paeshuyse, Johan Neyts, Matheus Froeyen, Piet Herdewijn, Baba Masanori .  Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives .  Antiviral Research83   263 - 268   2010.12Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivativesReviewed

Nakamura Masahiko, Aoyama Atsushi, Mohammed T.A. Salim, Okamoto Mika, Baba Masanori, Miyachi Hiroyuki, Hashimoto Yuichi, Aoyama Hiroshi .  Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton .  Bioorganic & Medicinal Chemistry Letters 18   2402 - 2411   2010.4Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeletonReviewed

Mohammed T.A. Salim, Okamoto Mika, Hosoda Shinnosuke, Aoyama Hiroshi, Baba Masanori, Hashimoto Yuichi .  Anti-bovine viral diarrhoea virus activity of novel diphenylmethane derivatives. .  Antiviral Chemistry & Chemotherapy20   193 - 200   2010.4Anti-bovine viral diarrhoea virus activity of novel diphenylmethane derivatives.Reviewed

Misawa T, Salim MTA, Okamoto M, Baba M, Aoyama H, Hashomoto Y, Sugita K. .  Synthesis and anti-hepatitis C virus activity of morpholino triazine derivatives. .  Heterocycles81   1419 - 1426   2010 Synthesis and anti-hepatitis C virus activity of morpholino triazine derivatives.Reviewed International coauthorship

Okamoto M, Sakai M, Goto Y, Salim MTA, Baba C, Goto K, Watashi K, Shimotohno K, Baba M. .  Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560. .    25   47 - 54   2009.9Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560.Reviewed

Minyi Shia, Xin Wangb, Mika Okamoto, Sonshin Takaoa, Masanori Baba .  Inhibition of porcine endogenous retrovirus (PERV) replication by HIV-1 gene expression inhibitors .  Antiviral Research83 ( 2 ) 201 - 204   2009.8Inhibition of porcine endogenous retrovirus (PERV) replication by HIV-1 gene expression inhibitors Reviewed

Hosoda Shinnosuke, Aoyama Hiroshi, Goto Yukinori, Mohammed T.A. Salim, Okamoto Mika, Hashimoto Mariko, Baba Masanori, Hashimoto Yuichi .  Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents .  Bioorganic & Medicinal Chemistry Letters 19   3157 - 3161   2009.6Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agentsReviewed

Aoyama H, Sako K, Sato S, Nakamura M, Miyachi H, Goto Y, Okamoto M, Baba M, Hashimoto Y. .  Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity. .  Heterocycles77   779 - 785   2009Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity. Reviewed

Baba Masanori, Okamoto Mika, Hamasaki Takayuki, Horai Sawako, Wang Xing, Ito Yuji, Suda Yasuo, Arima Naomichi. .  Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells. .  Journal of Virology82 ( 8 ) 3843 - 3852   2008.4Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells. Reviewed

Xing WANG, Kazunobu YAMOTAKA, Mika OKAMOTO, Satoru IKEDA, Masanori BABA .  Potent and selective inhibition of Tat-dependent HIV-1 replication in chronically infected cells by a novel naphthalene derivative JTK-101. .  Antiviral Chemistry & Chemotherapy18 ( 4 ) 201 - 211   2007.8Potent and selective inhibition of Tat-dependent HIV-1 replication in chronically infected cells by a novel naphthalene derivative JTK-101.Reviewed

Baba M, Miyake H, Wang X, Okamoto M, Takashima K. .  Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652 .  Antimicribial Agents and Chemotherapy51 ( 2 ) 707 - 715   2007.2Isolation and characterization of human immunodeficiency virus type 1 resistant to the small-molecule CCR5 antagonist TAK-652Reviewed

岡本実佳(OKAMOTOMIKA) .  第6回ECC山口メモリアルエイズ研究奨励賞受賞研究宿主細胞因子を標的にしたHIV-1抑制に関する研究(Cellular Factors as Targets for Anti-HIV-1 Chemotherapy) .  日本エイズ学会誌(The Journal of AIDS Research)8 ( 2 ) 92 - 99   2006.5第6回ECC山口メモリアルエイズ研究奨励賞受賞研究宿主細胞因子を標的にしたHIV-1抑制に関する研究(Cellular Factors as Targets for Anti-HIV-1 Chemotherapy)Invited Reviewed

Okamoto M, Wang X, Baba M. .  HIV-1-infected macrophages induce astrogliosis by SDF-1a and matrix metalloproteinases .  Biochemical and Biophysical Research Communications336 ( 4 ) 1214 - 1220   2005.11HIV-1-infected macrophages induce astrogliosis by SDF-1a and matrix metalloproteinasesReviewed

Wang X, Uto T, Sato K, Ide K, Akagi T, Okamoto M, Kaneko T, Akashi M, Baba M. .  Potent activation of antigen-specific T cells by antigen-loaded nanospheres .  Immunology Letters98 ( 1 ) 123 - 130   2005.4Potent activation of antigen-specific T cells by antigen-loaded nanospheresReviewed

Wang X, Nitanda T, Shi M, Okamoto M, Furukawa T, Sugimoto Y, Akiyama S, Baba M. .  Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance protein .  Biochemical Pharmacology68 ( 7 ) 1363 - 1370   2004.10Induction of cellular resistance to nucleoside reverse transcriptase inhibitors by the wild-type breast cancer resistance proteinReviewed

Okamoto M, Wang X, Debyser Z, De Clercq E, Baba M. .  Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof .  Journal of Virological Methods108 ( 2 ) 195 - 203   2003.3Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereofReviewed International coauthorship

Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M. .  Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors .  Molecular Pharmacoloy63 ( 1 ) 65 - 72   2003.1Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitorsReviewed

Wang X, Miyake H, Okamoto M, Saito M, Fujiwara J, Tanaka Y, Izumo S, Baba M. .  Inhibition of the Tax-dependent human T-lymphotropic virus type I replication in persistently infected cells by the fluoroquinoline derivative K-37. .  Mol. Pharmacol.61   1359 - 1365   2002.6Inhibition of the Tax-dependent human T-lymphotropic virus type I replication in persistently infected cells by the fluoroquinoline derivative K-37. Reviewed International coauthorship

Wang X, Okamoto M, Kawamura M, Izumo S, Baba M. .  Inhibition of human T- lymphotropic virus type I gene expression by the Streptomyces-derived substance EM2487. .  Antiviral Chem. Chemother.13   177 - 183   2002.5 Inhibition of human T- lymphotropic virus type I gene expression by the Streptomyces-derived substance EM2487.Reviewed International coauthorship

Okamoto M, Ono M, Baba M. .  Suppression of cytokine production and neural cell death by the anti-inflammatory alkaloid cepharanthine: a potential agent against HIV-1 encephalopathy. .  Biochem. Pharmacol.62   747 - 753   2001.9Suppression of cytokine production and neural cell death by the anti-inflammatory alkaloid cepharanthine: a potential agent against HIV-1 encephalopathy. Reviewed

Baba M, Okamoto M, Kashiwaba N, Ono M. .  Anti-HIV-1 activity and structure- activity relationship of cepharanoline derivatives in chronically infected cells. .  Antiviral Chem. Chemother.12   307 - 312   2001.9Anti-HIV-1 activity and structure- activity relationship of cepharanoline derivatives in chronically infected cells.Reviewed

Fujii R, Okamoto M, Aratani S, Oishi T, Ohshima T, Taira K, Baba M, Fukamizu A, Nakajima T. .  A role of RNA helicase A in cis-acting transactivation response element-mediated transcriptional regulation of human immunodeficiency virus type 1. .  J. Biol. Chem.276   5445 - 5451   2001.2A role of RNA helicase A in cis-acting transactivation response element-mediated transcriptional regulation of human immunodeficiency virus type 1. Reviewed

Okamoto H, Cujec TP, Okamoto M, Peterlin BM, Baba M, Okamoto T. .  Inhibition of the RNA-dependent transactivation and replication of human immunodeficiency virus type 1 by a fluoroquinoline derivative K-37. .  Virology272   402 - 408   2000.7Inhibition of the RNA-dependent transactivation and replication of human immunodeficiency virus type 1 by a fluoroquinoline derivative K-37. Reviewed International coauthorship

Baba M, Miyake H, Okamoto M, Iizawa Y, Okonogi K. .  Establishment of a CCR5-expressing T-lymphoblastoid cell line highly susceptible to R5 HIV-1. .  AIDS Res. Hum. Retrovir. 16   935 - 941   2000.7 Establishment of a CCR5-expressing T-lymphoblastoid cell line highly susceptible to R5 HIV-1.Reviewed

Shiraishi M, Aramaki Y, Seto M, Imoto H, Nishikawa Y, Kanzaki N, Okamoto M, Sawada H, Nishimura O, Baba M, Fujino M. .  Discovery of novel, potent and selective small molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety. .  J. Med. Chem.43   2049 - 2063   2000.5Discovery of novel, potent and selective small molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety.Reviewed

Fujiwara M, Okamoto M, Okamoto M, Watanabe M, Machida H, Shigeta S, Konno K, Yokota T, Baba M. .  Acridone derivatives are selective inhibitors of HIV-1 replication in chronically infected cells. .  Antiviral Res.43   189 - 199   1999.10Acridone derivatives are selective inhibitors of HIV-1 replication in chronically infected cells.Reviewed

Baba M, Okamoto M, Takeuchi T. .  Inhibition of human immunodeficiency virus type 1 replication in acutely and chronically infected cells by EM2487, a novel substance produced by a Streptomyces species. .  Antimicrob. Agents Chemother. 43   2350 - 2355   1999.10Inhibition of human immunodeficiency virus type 1 replication in acutely and chronically infected cells by EM2487, a novel substance produced by a Streptomyces species.Reviewed

Baba M, Nishimura O, Kanzaki N, Okamoto M, Sawada H, Iizawa Y, Shiraishi M, Aramaki Y, Okonigi K, Ogawa Y, Meguro K, Fujino M. .  A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. .  Proc. Natl. Acad. Sci. USA 96   5698 - 5703   1999.5A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity.Reviewed

Okamoto M, Okamoto T, Baba M. .  Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. .  Antimicrob. Agents Chemother. 43   492 - 497   1999.5Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells.Reviewed

Hayakawa T, Kawamura M, Okamoto M, Baba M, Niikawa T, Takehara S, Serizawa T, Akashi M. .  Concanavalin A-immobilized polystyrene nanospheres capture HIV-1 virions and gp120: potential approach towards prevention of viral transmission. .  J. Med. Virol. 56   327 - 331   1998.12Concanavalin A-immobilized polystyrene nanospheres capture HIV-1 virions and gp120: potential approach towards prevention of viral transmission. Reviewed

Okamoto M, Ono M, Baba M. .  Potent inhibition of HIV-1 replication by an anti-inflammatory alkaloid, cepharanthine, in chronically infected monocyte cells. .  AIDS Res. Hum. Retrovir. 14   1239 - 1245   1998.9Potent inhibition of HIV-1 replication by an anti-inflammatory alkaloid, cepharanthine, in chronically infected monocyte cells. Reviewed

Baba M, Okamoto M, Kawamura M, Makino M, Higashida T, Takashi T, Kimura Y, Ikeuchi T, Tetsuka T, Okamoto T. .  Inhibition of human immunodeficiency virus type 1 replication and cytokine production by fluoroquinoline derivatives. .  Mol. Pharmacol.53   1097 - 1103   1998.6 Inhibition of human immunodeficiency virus type 1 replication and cytokine production by fluoroquinoline derivatives. Reviewed

Fujiwara M, Okamoto M, Ijichi K, Tokuhisa K, Hanasaki Y, Katsuura K, Uemura D, Shigeta S, Konno K, Yokota T, Baba M. .  Upregulation of HIV-1 replication in chronically infected cells by ingenol derivatives. .  Arch. Virol. 143   2003 - 2010   1998Upregulation of HIV-1 replication in chronically infected cells by ingenol derivatives. Reviewed

Okamoto M, Yasukawa K, Katsuura K, Baba M. .  Inhibition of interleukin- 6-induced human immunodeficiency virus type 1 expression by anti-gp130 monoclonal antibody. .  Biochem. Mol. Biol. Int.43   733 - 749   1997.11Inhibition of interleukin- 6-induced human immunodeficiency virus type 1 expression by anti-gp130 monoclonal antibody.Reviewed

Baba M, Okamoto M, Makino M, Kimura Y, Ikeuchi T, Sakaguchi T, Okamoto T. .  Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives. .  Antimicrob. Agents Chemother. 41   1250 - 1255   1997.6Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives.Reviewed

Okamoto M, Makino M, Kitajima I, Maruyama I, Baba M. .  HIV-1-infected myelomonocytic cells are resistant to Fas-mediated apoptosis: Effect of tumor necrosis factor-a on their Fas expression and apoptosis. .  Med. Microbiol. Immunol.186   11 - 17   1997.6HIV-1-infected myelomonocytic cells are resistant to Fas-mediated apoptosis: Effect of tumor necrosis factor-a on their Fas expression and apoptosis.Reviewed

Hashimoto K, Tsunoda R, Okamoto M, Shigeta S, Baba M. .  Stavudine (D4T) selectively induces apoptosis in HIV-1 infected cells. .  AIDS Res. Hum. Retrovir. 13   193 - 199   1997.1Stavudine (D4T) selectively induces apoptosis in HIV-1 infected cells. Reviewed

Okamoto M, Makino M, Yamada K, Nakade K, Yuasa S, Baba M. .  Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1-infected cells. .  Antiviral Res. 31   69 - 77   1996.6Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1-infected cells.Reviewed

Asano N, Kizu H, Oseki K, Tomioka E, Matsui K, Okamoto M, Baba M. .  N-alkylated nitrogen-in-the-ring sugars: Coformational basis of inhibition of glycosidases and HIV-1 replication. .  J. Med. Chem. 38   2349 - 2356   1995.6N-alkylated nitrogen-in-the-ring sugars: Coformational basis of inhibition of glycosidases and HIV-1 replication. Reviewed

Okamoto M, Baba M, Kodama E, Sekine K, Takagi T, Kasukawa R, Shigeta S. .  Detection of hepatitis C virus genome in human serum by multi-targeted polymerase chain reaction. .  J. Med. Virol. 41   6 - 10   1993.6Detection of hepatitis C virus genome in human serum by multi-targeted polymerase chain reaction. Reviewed

HIV-1感染細胞殺傷剤及びその用途

岡本実佳、馬場昌範

成人T細胞白血病治療薬

岡本実佳、馬場昌範

HIV-1感染細胞殺傷剤及びその用途

岡本実佳、馬場昌範

成人T細胞白血病治療薬

岡本実佳、馬場昌範

成人T細胞白血病治療薬

岡本実佳、馬場昌範

レトロウイルスによる神経傷害機序：HAMとエイズ脳症患者資料を用いた多角的解析

2007.4 - 2010.3

科学研究費補助金  基盤研究(B)

HTLV-1感染特異的神経障害機構に基づくLV-1関連脊髄症発症機構の解明

2004.4 - 2007.3

科学研究費補助金  若手研究(B)