Updated on 2022/11/19

写真a

 
MIURA Naoki
 
Organization
Research Field in Veterinary Medicine, Agriculture, Fisheries and Veterinary Medicine Area Joint faculty of Veterinary Medicine Veterinary Hospital Professor
Title
Professor
External link

Degree

  • 博士(獣医学) ( 2001.3   山口大学 )

Research Interests

  • Comparative pathophysiology

  • thrombosis

  • 腫瘍

  • non-coding RNA

  • microRNA

  • 乳房炎

  • animal disease

  • 炎症

  • 疾患マーカー

  • 獣医学

  • 遺伝子導入

  • p53遺伝子

Research Areas

  • Life Science / Tumor biology

  • Life Science / Laboratory animal science

  • Life Science / Animal life science

  • Life Science / Molecular biology

Education

  • Yamaguchi University

    1997.4 - 2001.3

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    Country: Japan

  • Kagoshima University

    - 1997.3

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    Country: Japan

Research History

  • Kagoshima University   Research Field in Veterinary Medicine, Agriculture, Fisheries and Veterinary Medicine Area Joint faculty of Veterinary Medicine   Professor

    2019.10

  • Kagoshima University   Joint Graduate School of Veterinary Vedicine   Professor

    2019.10

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    Country:Japan

  • Kagoshima University   Professor

    2019.10

  • Kagoshima University   Research Field in Veterinary Medicine, Agriculture, Fisheries and Veterinary Medicine Area Joint faculty of Veterinary Medicine Veterinary Hospital   Associate Professor

    2012.4 - 2019.9

  • Kagoshima University   Joint faculty of Veterinary Medicine   Associate Professor

    2012.4 - 2019.9

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    Country:Japan

  • Kagoshima University   Faculty of Agriculture, Veterinary teaching Hospital   Associate Professor

    2008.4 - 2012.3

  • Kagoshima University   Graduate School of Medical and Dental Sciences   Chief Researcher

    2006.12 - 2008.3

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    Country:Japan

  • University of Kentucky   Gluck Equine Research Center   Researcher

    2003.5 - 2006.11

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    Country:United States

  • Cornell University   Barker Institute   Researcher

    2002.4 - 2003.4

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    Country:United States

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Committee Memberships

  • 日本獣医学会   評議員  

    2021.9   

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    Committee type:Academic society

  • 日本放射線学教育研究会   理事  

    2020.9   

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    Committee type:Academic society

  • Frontier in Veterinary Science (Oncology in Veterinary Medicine)   Associate Editor  

    2022.10   

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    Committee type:Other

  • Veterinary Record, Case Reports   Associate Editor-Diagnostic imaging  

    2016   

  • Frontier in Veterinary Science (Veterinary Experimental and Diagnostic Pathology)   Review Editor  

    2021.8   

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    Committee type:Other

  • Journal of Veterinary Medical and One Health Research   Invited Editor  

    2019   

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    Committee type:Other

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Studying abroad experiences

  • 2003.5 - 2006.11   University of Kentucky  

  • 2002.4 - 2003.4   Cornell University  

  • 2014.2 - 2014.3   University of Kentucky   Visiting Scientist

 

Papers

  • Aritada Yoshimura, Takahiro Ohmori, Daiki Hirao, Miori Kishimoto, Tomoko Iwanaga, Naoki Miura, Kazuhiko Suzuki, Ryuji Fukushima .  Protective Effect on Pancreatic Acinar Cell by Maintaining Cardiac Output in Canine Heart Failure Model With Decreased Pancreatic Blood Flow .  Frontiers in Veterinary Science9   925847   2022.7Reviewed International journal

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    Heart failure cause hypoperfusion-induced damage to abdominal organs due to decreased cardiac output (CO). Using a model dog with heart failure caused by rapid ventricular pacing (RVP), we have previously demonstrated that a decrease in CO reduces pancreatic blood flow (PBF). Furthermore, we have revealed that pancreatic acinar cell atrophy, which is a change in the pre-stage of pancreatitis was caused. However, the mechanism by which pancreatic acinar cell atrophy was caused in RVP dogs remains unknown. This study aimed to clarify the association between cardiac function, PBF, and histopathological changes in pancreatic acinar cells by administrating pimobendan, which increase CO, to RVP dogs. RVP dogs were divided into the control group (no medication, n = 5) and the pimobendan group (pimobendan at 0.25 mg/kg BID, n = 5). Non-invasive blood pressure measurement, echocardiography, and contrast-enhanced ultrasonography for PBF measurement were performed before initiating RVP and at 4 weeks after initiating RVP (4 weeks). At 4 weeks, the decreases in CO, mean blood pressure and PBF due to RVP were suppressed in pimobendan group. Furthermore, histopathological examination showed no changes in pancreatic acinar cells in the pimobendan group. Overall, it was clarified that the decrease in PBF due to cardiac dysfunction was a direct cause of pancreatic acinar cell atrophy. This suggests that maintaining PBF is clinically important for treating dogs with heart failure. In addition, these findings offer a reliable basis for developing new therapeutic strategies for heart failure in dogs, that is, pancreatic protection.

    DOI: 10.3389/fvets.2022.925847

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  • HUI-WEN CHEN, YU-CHANG LAI, MD MAHFUZUR RAHMAN, AL ASMAUL HUSNA, MD NAZMUL HASAN, HITOSHI HATAI, NORIAKI MIYOSHI, OSAMU YAMATO, NAOKI MIURA .  NGS-identified miRNAs in Canine Mammary Gland Tumors Show Unexpected Expression Alterations in qPCR Analysis .  In Vivo36 ( 4 ) 1628 - 1636   2022.6Reviewed International journal

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Anticancer Research USA Inc.  

    DOI: 10.21873/invivo.12873

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  • Ijiri M, Odo K, Sato M, Kawaguchi M, Fujimoto Y, Miura N, Matsuo T, Hou DX, Yamato O, Tanabe T, Kawaguchi H .  Potential biomarkers for chronic seasonal heat stress in Kagoshima Berkshire pigs reared in the subtropical region .  Journal of Veterinary Research66 ( 2 ) in press - 214   2022.5Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    Potential biomarkers for chronic seasonal heat stress in Kagoshima Berkshire pigs reared in the subtropical region were investigated by comparing the biomarker changes in the summer (a period of chronic heat stress) and winter (a thermoneutral period) seasons.

    Pigs were allocated to summer- and winter-finishing cohorts, 12 each. The evaluations included assessment of carcass traits and internal organs’ normality carried out at the time of slaughter, and measurement of biomarkers in whole blood: derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential as markers of oxidative stress, and serum amyloid A and albumin/globulin (A/G) ratio as markers of acute and chronic inflammation, respectively.

    The summer-finished pigs reared under subtropical field conditions showed lower carcass quality than the winter-finished pigs, indicating a potential adverse effect of summer temperatures on the swine industry. Marginal changes were observed in d-ROMs and the A/G ratio between the summer- and winter-finishing cohorts.

    The results demonstrate that d-ROMs and the A/G ratio could be used as sensitive markers for heat stress under field conditions.

    Keywords
    albumin/globulin ratioderivatives of reactive oxygen metabolites (d-ROMs)biological antioxidant potential (BAP)heat stressKagoshima Berkshire pigoxidative stress

    DOI: 10.2478/jvetres-2022-0024

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  • YONESHIGE Ryuichi, WADA Mie, HONKAWA Yusuke, MIURA Naoki, MIYOSHI Noriaki, ANDO Takaaki .  A clinical case of a subepiglottic cyst in a Japanese Black calf .  Journal of Veterinary Medical Science84 ( 7 ) 978 - 981   2022.5Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPANESE SOCIETY OF VETERINARY SCIENCE  

    <p>A 36-day-old Japanese Black calf exhibited wheezing associated with dyspnea from birth. Arterial blood gas analysis revealed a low oxygen partial pressure of 51 mmHg, low oxygen saturation of 83%, and high carbon dioxide partial pressure of 58.8 mmHg. Computed tomography, endoscopy, and ultrasonography showed cyst formation under the epiglottis. When the cyst was aspirated under ultrasonic guidance to secure the airway, 30 ml of viscous white turbid content was aspirated. The cyst shrank immediately after aspiration, but the wheezing and respiratory symptoms resumed 7 days after aspiration. Therefore, the cyst was surgically removed from the ventral side of the neck. No cyst remodeling was observed 30 days after surgical removal.</p>

    DOI: 10.1292/jvms.22-0183

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  • Chen H.W. .  Micro RNA differential expression profile in canine mammary gland tumor by next generation sequencing .  Gene818   146237   2022.4Reviewed International coauthorship International journal

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Gene  

    Canine mammary gland tumors are very common and represent a potential model of human breast cancer, and microRNA (miRNAs) are promising biomarkers and therapeutic targets for these tumors. Accordingly, we aimed to identify miRNAs differentially expressed in canine mammary gland tumors using next generation sequencing (NGS), with subsequent confirmatory qPCR and target gene analyses. Mammary gland tissue was collected from healthy dogs (n=7) and dogs with suspected tumors (n=80). A subset of samples was analyzed with NGS to identify differentially expressed miRNAs with CLC Genome Workbench. Normal (n=10), tumor-adjacent (n=6), and tumor-bearing (n=76) mammary gland tissue samples were analyzed for the identified miRNAs using qPCR. An in silico analysis (TargetScan) was performed to predict the miRNAs’ target genes using gene ontology (GO) terms and the Kyoto Encyclopedia of Genes and Genomes (KEGG) database (DAVID). We identified four miRNAs (cfa-miR-1-3p, cfa-miR-133a-3p, cfa-miR-133b-3p, and cfa-miR-133c-3p) as down regulated in canine mammary gland tumor tissues relative to normal and tumor adjacent tissues. KEGG analysis revealed the potential target genes of cfa-miR-1-3p are related to the Rap1 signaling pathway, adherens junction, and Ras signaling pathway, and those of the miR-133 family are related to the TGF-beta signaling pathway, synaptic vesicle cycle, and sphingolipid signaling pathway. In combination, these target genes are related to the regulation of transcription and DNA binding transcription (GO analysis), and the Hippo signaling pathway, adherens junction, and endocytosis (KEGG analysis). Accordingly, we suggest these four miRNAs are promising potential biomarker candidates for canine mammary gland tumors warranting further investigation.

    DOI: 10.1016/j.gene.2022.146237

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  • Husna A.A., Rahman M.M., Chen H.W., Hasan M.N., Nakagawa T., Miura N. .  Long non-coding RNA and transfer RNA-derived small fragments in exosomes are potential biomarkers for canine oral melanoma .  Veterinary and Comparative Oncology20 ( 3 ) 653 - 663   2022.4Reviewed International journal

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Veterinary and Comparative Oncology  

    Novel small non-coding RNAs (sRNAs) represent an emerging line of research in both human and canine oncology, due to their diverse regulatory and functional roles. Novel sRNAs are regarded as distinct from microRNAs, although both are part of the exosomal cargo. Recently, we reported on exosomal miRNAs as biomarkers for canine melanoma; however, it is unknown if novel sRNAs hold similar potential. Accordingly, we aimed to identify and validate novel sRNAs as potential biomarkers of canine oral melanoma, as part of our larger project on sequencing small exosomal RNA for this disease. Next generation sequencing revealed several differentially expressed novel sRNAs in exosomes from two melanoma cell lines (KMeC and LMeC) when compared with reference exosomes (from tumour-free dogs). Among these novel sRNAs, long noncoding RNA fragments, tRNA-derived fragments, snoRNAs and snRNAs were abundantly expressed. We selected four novel sRNAs upregulated in each cell line, and validated their aberrant expression with qPCR. In analysis using plasma-derived exosomes from melanoma patients, six out of the eight selected novel sRNAs showed significantly elevated expression. Receiver operating curve (ROC) analysis showed that one long non-coding RNA-derived small fragment (ENSCAFT00000069599.1) and one transfer RNA-derived small fragment (tRNA-Ala-TGC-5-1) have more than 85% sensitivity and specificity for differentiating melanoma patients from tumour-free dogs. Therefore, we consider that novel sRNAs may serve as candidate biomarkers to facilitate more accurate diagnosis of canine oral melanoma in clinical settings.

    DOI: 10.1111/vco.12818

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  • Ozawa T, Miura N, Hasegawa H, Uemura T, Nakamoto Y, Tsujio M, Takeuchi T, Shiraishi M .  Characteristics and outcome of suspected cerebrovascular disease in dogs: 66 cases (2009-2016) .  Journal of Small Animal Practice63 ( 1 ) 45 - 51   2021.9Reviewed International journal

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Small Animal Practice  

    Objectives : To characterise the clinical signs of suspected cerebrovascular disease in dogs. Materials and Methods : Medical records of one hospital were searched from November 2009 to December 2016 for dogs that suffered of cerebrovascular disease. We diagnosed cerebrovascular disease based on acute onset, clinical signs and magnetic resonance imaging findings. The medical history, clinical signs, concurrent disease, area of infarction, cerebrospinal fluid results, month at onset and outcome were investigated in the cerebrovascular disease group and in a control group (dogs with brain disorders other than cerebrovascular disease). Results : A total of 122 CVD cases were extracted from the 5312 patients that visited during the study period. Of these 122 cases, 66 (1.2%) matched the subject selection criteria of our study and were included in the analysis. Forebrain infarction was observed in 51 of 66 cases, of which 24 (47.1%) suffered from seizures. The number of dogs diagnosed with cerebrovascular disease was disproportionately high in August (nine of 59 cases) and December (13 of 59 cases). In the outcome survey, deterioration was observed in 11 of 55 cases. Clinical Significance : Seizure is an important clinical sign of cerebrovascular disease in dogs. There was a significant seasonal variation in the number of dogs diagnosed with cerebrovascular disease in Japan. Clinical features observed in this report differ from those of previous reports and highlight the need for additional research in this area.

    DOI: 10.1111/jsap.13422

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  • Al Asmaul Husna, Md Mahfuzur Rahman, Yu-Chang Lai, Hui-Wen Chen, Md Nazmul Hasan, Takayuki Nakagawa, Naoki Miura .  Identification of melanoma-specific exosomal miRNAs as the potential biomarker for canine oral melanoma. .  Pigment cell & melanoma research34 ( 6 ) 1062 - 1073   2021.7Reviewed International journal

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    Considering the importance of the canine cancer model of human disease, as well as the need for strategies for canine cancer management, the properties of exosomes are an emerging topic in canine oncology. In our study, exosomal RNA was isolated and investigated by next-generation sequencing. We identified several differentially expressed microRNAs (miRNAs/miRs) in the exosomes of two melanoma cell lines compared with non-tumor reference exosomes. We explored these potential melanoma-specific exosomal miRNAs further and found that miR-143 and let-7b increased in primary, whereas miR-210, 708, 221, and 222 increased in metastatic site originated melanoma cells. Further analysis showed miR-143 and 221 significantly increased in plasma exosomes of metastatic melanoma patients. Moreover, the sensitivity and specificity are >85% for differentiating the non-metastatic and metastatic patients. Therefore, these miRNAs can be an incredible biomarker candidate to identify metastatic melanoma and facilitate a better prognosis.

    DOI: 10.1111/pcmr.13000

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  • Yasunori Hino, Md Mahfuzur Rahman, Yu-Chang Lai, Al Asmaul Husna, Hui-Wen Chen, Md Nazmul Hasan, Takayuki Nakagawa, Naoki Miura .  Hypoxic miRNAs expression are different between primary and metastatic melanoma cells. .  Gene782   145552 - 145552   2021.5Reviewed International coauthorship International journal

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    MicroRNAs (miRNAs) can rapidly respond to cellular stresses, such as hypoxia. This immediate miRNA response regulates numerous genes and influences multiple signaling pathways. Therefore, identifying hypoxia-regulated miRNAs (HRMs) is important in canine oral melanoma (COM) to investigate their clinical significance. The hypoxic and normoxic miRNA profiles of two COM cell lines were investigated by next generation sequencing. HRMs were identified by comparing miRNA expression profiles in these cell lines with that in COM tissue. The HRM profile was different between cell lines of primary and metastatic origin, except for miR-301a and miR-8884. The time course of miRNA expression determined by qRT-PCR, especially for miR-210 and miR-301a, showed that metastatic cells are more resistant to hypoxia than primary cells. Analysis of an experimentally validated human miRNA target database revealed that miR-21 and miR-301a control a complex gene regulatory network in response to hypoxia, which includes pathways of well-known oncogenes, such as VEGF, PTEN, and TGFBR2. In conclusions, we revealed the HRM of COM. Moreover, our study shows the difference in regulation and response of hypoxic miRNAs between primary and metastatic originated melanoma cells.

    DOI: 10.1016/j.gene.2021.145552

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  • Yoshimura A, Ohmori T, Itou K, Ishi R, Matsumura Y, Wada Y, Kishimoto M, Iwanaga T, Miura N, Suzuki K, Fukushima R .  Histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model. .  The Journal of veterinary medical science83 ( 5 ) 780 - 783   2021.5Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPANESE SOCIETY OF VETERINARY SCIENCE  

    In dogs, pancreatic acinar cell injury is thought to be caused by decreased pancreatic blood flow due to heart failure. In previous our report, it demonstrated that decreased heart function causes a significant decrease in pancreatic blood flow in heart failure dog model caused by rapid ventricular pacing (RVP). However, the types of histopathological changes remain unclear. We aimed to verify the types of histopathological changes occurring in the pancreatic tissue due to decreased heart function. After RVP for 4 weeks, atrophy of pancreatic acinar cells, characterized by a decrease in zymogen granules, was observed in all areas of the pancreas. In conclusion, the result of this study suggests that attention should be paid to ischemia/hypoperfusion injury in the pancreas.

    DOI: 10.1292/jvms.20-0409

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  • Iwanaga T, Fukushima R, Nagasato T, Maruyama I, Miura N .  Analysis of blood clotting with the total thrombus analysis system in healthy dogs .  J Vet Diagn Invest32 ( 2 ) 357 - 361   2021.2Analysis of blood clotting with the total thrombus analysis system in healthy dogsReviewed International journal

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    DOI: 10.1177/1040638721991862

  • MOE IJIRI, YU-CHANG LAI, HIROAKI KAWAGUCHI, YOSHIKAZU FUJIMOTO, NAOKI MIURA, TOMOHIDE MATSUO, AKIHIDE TANIMOTO .  NR6A1 Allelic Frequencies as an Index for both Miniaturizing and Increasing Pig Body Size .  In Vivo35 ( 1 ) 163 - 167   2021.1Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Anticancer Research USA Inc.  

    DOI: 10.21873/INVIVO.12244

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  • Nakatomi K, Ueno H, Ishikawa Y, Salim RC, Mori Y, Kanemoto I, Tancharoen S, Kikuchi K, Miura N, Omori T Okuda-Ashitaka E, Matsumura K, Imaizumi H, Motomiya Y, Maruyama I, Kawahara K .  TLR4/MD-2 is a receptor for extracellular nucleophosmin 1 .    14 ( 2 ) 21 - 6   2020.12Reviewed International journal

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    DOI: 10.3892/br.2020.1397

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  • Lai YC, Habiby GH, Jasing Pathiranage CC, Rahman MM, Chen HW, Husna AA, Kubota C, Miura N .  Bovine serum miR-21 expression affected by mastitis. .  Res Vet Sci135   290 - 292   2020.11Bovine serum miR-21 expression affected by mastitis. Reviewed International journal

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.rvsc.2020.10.001

    Other Link: https://www.ncbi.nlm.nih.gov/pubmed/33162110

  • Kake S, Kawaguchi H, Nagasato T, Yamada T, Ito T, Maruyama I, Miura N*, Tanimoto A .  Association Between HMGB1 and Thrombogenesis in a Hyperlipaemia-induced Microminipig Model of Atherosclerosis .  In Vivo34 ( 4 ) 1871 - 1874   2020.7Association Between HMGB1 and Thrombogenesis in a Hyperlipaemia-induced Microminipig Model of AtherosclerosisReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/invivo.11982

  • Iwanaga T. .  A Novel Microchip Flow Chamber (Total Thrombus Analysis System) to Assess Canine Hemostasis .  Frontiers in Veterinary Science7   307   2020.6Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Frontiers in Veterinary Science  

    DOI: 10.3389/fvets.2020.00307

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  • Yoshimura, A. Ohmori, T. Yamada, S. Kawaguchi, T. Kishimoto, M. Iwanaga, T. Miura, N. Fukushima, R. .  Comparison of pancreatic and renal blood flow in a canine tachycardia-induced cardiomyopathy model .  J Vet Med Sci   2020.4Comparison of pancreatic and renal blood flow in a canine tachycardia-induced cardiomyopathy modelReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamazaki, H. Tanaka, T. Mie, K. Nishida, H. Miura, N. Akiyoshi, H. .  Assessment of postoperative adjuvant treatment using toceranib phosphate against adenocarcinoma in dogs .  J Vet Intern Med   2020.4Assessment of postoperative adjuvant treatment using toceranib phosphate against adenocarcinoma in dogsReviewed

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    DOI: 10.1111/jvim.15768

  • 三浦 直樹 .  A Novel Microchip Flow Chamber (Total Thrombus Analysis System) to Assess Canine Hemostasis .  Frontiers in Veterinary Science, section Veterinary Experimental and Diagnostic PathologyIn Press   2020A Novel Microchip Flow Chamber (Total Thrombus Analysis System) to Assess Canine HemostasisReviewed International coauthorship International journal

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  • Rahman, M. Lai, Y. C. Husna, A. A. Chen, H. W. Tanaka, Y. Kawaguchi, H. Hatai, H. Miyoshi, N. Nakagawa, T. Fukushima, R. Miura, N. .  Aberrantly expressed snoRNA, snRNA, piRNA and tRFs in canine melanoma .  Vet Comp Oncol   2019.11Aberrantly expressed snoRNA, snRNA, piRNA and tRFs in canine melanomaReviewed

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    DOI: 10.1111/vco.12558

  • Lai YC, Lai YT, Rahman MM, Chen HW, Husna AA, Fujikawa T, Ando T, Kitahara G, Koiwa M, Kubota C, Miura N. .  Bovine milk transcriptome analysis reveals microRNAs and RNU2 involved in mastitis .  FEBS J287 ( 9 ) 1899 - 1918   2019.10Bovine milk transcriptome analysis reveals microRNAs and RNU2 involved in mastitisReviewed

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    DOI: 10.1111/febs.15114

    Other Link: https://www.ncbi.nlm.nih.gov/pubmed/31663680

  • Rahman MM, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Hatai H, Miyoshi N, Nakagawa T, Fukushima R, Miura N. .  Transcriptome analysis of dog oral melanoma and its oncogenic analogy with human melanoma .  Oncol Rep   2019.10Transcriptome analysis of dog oral melanoma and its oncogenic analogy with human melanomaReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/or.2019.7391

  • Rahman MM, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Miyoshi N, Nakagawa T, Fukushima R, Miura N .  Micro RNA Transcriptome Profile in Canine Oral Melanoma. .  Int J Mol Sci20 ( 19 )   2019.10Micro RNA Transcriptome Profile in Canine Oral Melanoma. Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms20194832

  • Kawaguchi H, Horie M, Onoue K, Noguchi M, Akioka K, Masatani T, Miura N, Ozawa M, Tanimoto A .  Development of a Model of Porcine Epidemic Diarrhea in Microminipigs .  Vet Pathol56 ( 5 ) 711 - 714   2019.4Development of a Model of Porcine Epidemic Diarrhea in MicrominipigsReviewed

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    DOI: 10.1177/0300985819839236

  • Yamada Shusaku, Hirao Daiki, Miura Naoki, Iwanaga Tomoko, Kawaguchi Takae, Yoshimura Aritada, Oomori Takahiro, Nagasato Tomoka, Maruyama Ikuro, Fukushima Ryuji .  急速心房ペーシング後の急性期における心房内と末梢領域における血液凝固性の比較(Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacing) .  Experimental Animals68 ( 2 ) 137 - 146   2019.4急速心房ペーシング後の急性期における心房内と末梢領域における血液凝固性の比較(Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacing)

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    Publisher:(公社)日本実験動物学会  

    微少循環系の血流の血栓形成を総合的に評価できる総合的血栓形成評価システム(T-TAS)を用いて、心房細動を模したイヌ実験モデルの急速心房ペーシング(RAP)直後の心房内と末梢領域における血液凝固を比較した。その結果、ペーシング30分後の心房血では、ARチップ(凝固系と血小板のミックスした血栓分析のためのチップ)による+10kPaまでの凝固機能評価時間(T10)と閉塞時間(OT)の両方が、ペーシング前に比べて有意に短縮した。ペーシング30分後の心房血のPLチップ(血小板血栓分析のためのチップ)によるOTは、ペーシング前に比べて有意に短縮した。一方、末梢血ではARチップとOTチップによる、T10でもOTでもRAPによって有意な変化はなかった。以上、RAP発症30分後には血液凝集の上昇が示唆されたことから、末梢血での凝集性に変化がなかったとしても、心房細動後早期に抗血栓治療を始めたほうが良いと考えられた。

  • Ushio N, Rahman MM, Maemura T, Lai YC, Iwanaga T, Kawaguchi H, Miyoshi N, Momoi Y, Miura N .  Identification of dysregulated microRNAs in canine malignant melanoma. .  Oncol Lett 17 ( 1 ) 1080 - 1088   2019.1Identification of dysregulated microRNAs in canine malignant melanoma.Reviewed

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    DOI: 10.3892/ol.2018.9692

  • Yamada S. Hirao D. Miura N. Iwanaga T. Kawaguchi T. Yoshimura A. Oomori T. Nagasato T. Maruyama I. Fukushima R. .  Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacing .  Exp Anim   2018.11Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacingReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1538/expanim.18-0100

  • Rahman MM. Amin KB. Rahman SMM. Khair A. Rahman M. Hossain A. Rahman A. Parvez MS. Miura N. Alam MM. .  Investigation of methicillin-resistant Staphylococcus aureus among clinical isolates from humans and animals by culture methods and multiplex PCR .  BMC Vet Res14 ( 1 ) 300   2018.10Investigation of methicillin-resistant Staphylococcus aureus among clinical isolates from humans and animals by culture methods and multiplex PCRReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12917-018-1611-0

  • Yamada S. Hirao D. Miura N. Iwanaga T. Kawaguchi T. Yoshimura A. Oomori T. Nagasato T. Maruyama I. Fukushima R. .  Comparison of chronological changes in blood characteristics in the atrium and peripheral vessels after the development of non-valvular atrial fibrillation .  Thromb Res171   31 - 37   2018.9Comparison of chronological changes in blood characteristics in the atrium and peripheral vessels after the development of non-valvular atrial fibrillationReviewed

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    DOI: 10.1016/j.thromres.2018.09.040

  • Kakihana Y. Kamikokuryo C. Furubeppu H. Madokoro Y. Futatsuki T. Miyamoto S. Haraura H. Hatanaka K. Eguchi T. Saitoh Y. Miura N. Suzuki H. Ueda Y. Yasuda T. Ito T. .  Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine Study .  Adv Exp Med Biol1072   583 - 590   2018.9Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine StudyReviewed

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    DOI: 10.1007/978-3-319-91287-5_14

  • Lai Y.C. .  Aberrant expression of microRNAs and the miR-1/MET pathway in canine hepatocellular carcinoma .  Veterinary and Comparative Oncology16 ( 2 ) 288 - 296   2018.6Invited Reviewed

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    DOI: 10.1111/vco.12379

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  • Abe M, Kawaguchi H, Miura N, Akioka K, Ushikai M, Oi S, Yukawa A, Yoshikawa T, Izumi H, Horiuchi M. .  Diurnal Variation of Melatonin Concentration in the Cerebrospinal Fluid of Unanesthetized Microminipig .  In Vivo32 ( 3 ) 583 - 590   2018.4Diurnal Variation of Melatonin Concentration in the Cerebrospinal Fluid of Unanesthetized MicrominipigReviewed

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    DOI: 10.21873/invivo.1127

  • Miura N. .  Bovine radiology: technical and diagnostic basics and pitfalls .  Japanese Journal of Large Animal Clinics8 ( 0 ) 269 - 275   2018Reviewed International journal

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society of Large Animal Clinics / Large Animal Clinic Research Association  

    <p> In recent years, diagnostic imaging has advanced in the veterinary field, and digital radiography has become more common in livestock animals. This review summarizes image characteristics obtained by different imaging parameters and the pitfalls of image interpretation using actual clinical cases.</p>

    DOI: 10.4190/jjlac.8.269

  • 三浦 直樹 .  CT検査で骨病変を確認した多発性骨髄腫の犬の症例 .  伴侶動物画像診断2 ( 6 ) 68 - 75   2017.12CT検査で骨病変を確認した多発性骨髄腫の犬の症例

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  • Yamada Sohsuke, Kawaguchi Hiroaki, Yamada Tomonobu, Guo Xin, Matsuo Kei, Hamada Taiji, Miura Naoki, Tasaki Takashi, Tanimoto Akihide .  コール酸はマイクロミニピッグにおける内臓脂肪症、アテローム性動脈硬化症、非アルコール性脂肪性肝疾患を悪化させる(Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs) .  Journal of Atherosclerosis and Thrombosis24 ( 11 ) 1150 - 1166   2017.11コール酸はマイクロミニピッグにおける内臓脂肪症、アテローム性動脈硬化症、非アルコール性脂肪性肝疾患を悪化させる(Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs)

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    Publisher:(一社)日本動脈硬化学会  

    マイクロミニピッグ(μMP)を用いて、肥満、血清脂質代謝、アテローム性動脈硬化、肝傷害、肝臓、全身マクロファージ活性化に対するコール酸(CA)の影響を評価した。μMPを高脂肪/高コレステロール食(HcD)群、HcDに0.7%CAを添加(HcD+CA)群に分け、8週間飼育した。飼育前後に腹部CTを行い、血糖値、血球数、血液化学、リポ蛋白質値、血圧を測定した。全器官を切除して組織学的および免疫組織化学検査を行った。mRNA発現をリアルタイムPCRで定量した。HcD+CA群はHcD群よりも内臓脂肪症、アテローム性動脈硬化の進行、高血清酸化ストレスマーカー値を示したが、血清脂質値は同じであった。肝臓では脂質蓄積が増加し、酸化ストレスマーカーの発現が高く、泡沫性クッパー細胞と星状細胞の活性化が促進し、肝細胞アポトーシスが増加し、非アルコール性脂肪性肝疾患(NAFLD)を示した。HcD+CA群では網内系、肺毛細血管、皮膚を含む種々の器官で泡沫性マクロファージの動員が観察された。CAは局所的および全身での酸化ストレスと炎症性サイトカインを発現亢進させ、種々の器官でのマクロファージを活性化させ、内臓型肥満、アテローム性動脈硬化、NAFLDを促進させた。

  • Lai YC, Fujikawa T, Ando T, Kitahara G, Koiwa M, Kubota C, Miura N. .  Rapid Communication: MiR-92a as a housekeeping gene for analysis of bovine mastitis-related microRNA in milk .  J Anim Sci95 ( 6 ) 2732 - 2735   2017.7Reviewed

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    DOI: 10.2527/jas.2017.1384

  • Yamazaki Hiroki, Miura Naoki, Lai Yu-Chang, Takahashi Masashi, Goto-Koshino Yuko, Momoi Yasuyuki, Nakaichi Munekazu, Tsujimoto Hajime, Setoguchi Asuka, Endo Yasuyuki .  犬における多剤耐性リンパ腫に対するリン酸トセラニブ(パラディア)の効果(Effects of toceranib phosphate(Palladia) monotherapy on multidrug resistant lymphoma in dogs) .  The Journal of Veterinary Medical Science79 ( 7 ) 1225 - 1229   2017.7犬における多剤耐性リンパ腫に対するリン酸トセラニブ(パラディア)の効果(Effects of toceranib phosphate(Palladia) monotherapy on multidrug resistant lymphoma in dogs)Reviewed International journal

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  • Yamazaki H, Miura N, Lai YC, Takahashi M, Goto-Koshino Y, Yasuyuki M, Nakaichi M, Tsujimoto H, Setoguchi A, Endo Y. .  Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma in dogs .  J Vet Med Sci79 ( 7 ) 1225 - 1229   2017.6Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma in dogsReviewed

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    DOI: 10.1292/jvms.16-0457

  • Zahorul Islam M, Kawaguchi H, Miura N, Miyoshi N, Yamazaki-Himeno E, Shiraishi M, Miyamoto A, Tanimoto A. .  Hypertension alters the endothelial-dependent biphasic response of bradykinin in isolated Microminipig basilar artery .  Microvasc Res114   52 - 57   2017.6Hypertension alters the endothelial-dependent biphasic response of bradykinin in isolated Microminipig basilar arteryReviewed

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    DOI: 10.1016/j.mvr.2017.06.001

  • Lai YC, Fujikawa T, Maemura T, Ando T, Kitahara G, Endo Y, Yamato O, Koiwa M, Kubota C, Miura N. .  Inflammation-related microRNA expression level in the bovine milk is affected by mastitis .  PLoS One12 ( 5 ) e0177182   2017.5Inflammation-related microRNA expression level in the bovine milk is affected by mastitisReviewed

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    DOI: 10.1371/journal.pone.0177182

  • Yamazaki H, Lai YC, Tateno M, Setoguchi A, Goto-Koshino Y, Endo Y, Nakaichi M, Tsujimoto H, Miura N. .  Hypoxia-activated prodrug TH-302 decreased survival rate of canine lymphoma cells under hypoxic condition .  PLoS One12 ( 5 ) e0177305   2017.5Hypoxia-activated prodrug TH-302 decreased survival rate of canine lymphoma cells under hypoxic conditionReviewed

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    DOI: 10.1371/journal.pone.0177305

  • Kiyoshi Kikuchi, Kentaro Setoyama, Ko-ichi Kawahara, Tomoka Nagasato, Takuto Terashi, Koki Ueda, Kazuki Nakanishi, Shotaro Otsuka, Naoki Miura, Hisayo Sameshima, Kazuya Hosokawa, Yoichiro Harada, Binita Shrestha, Mika Yamamoto, Yoko Morimoto-Yamashita, Haruna Kikuchi, Ryoji Kiyama, Chinatsu Kamikokuryo, Salunya Tancharoen, Harutoshi Sakakima, Motohiro Morioka, Eiichiro Tanaka, Takashi Ito, Ikuro Maruyama .  Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombiolysis .  OXIDATIVE MEDICINE AND CELLULAR LONGEVITY2017   6873281   2017

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    The combination of alteplase, a recombinant tissue plasminogen activator, and edaravone, an antioxidant, reportedly enhances recanalization after acute ischemic stroke. We examined the influence of edaravone on the thrombolytic efficacy of alteplase by measuring thrombolysis using a newly developed microchip-based flow-chamber assay. Rat models of embolic cerebral ischemia were treated with either alteplase or alteplase-edaravone combination therapy. The combination therapy significantly reduced the infarct volume and improved neurological deficits. Human blood samples from healthy volunteers were exposed to edaravone, alteplase, or a combination of alteplase and edaravone or hydrogen peroxide. Whole blood was perfused over a collagen- and tbromboplastin-coated microchip; capillary occlusion was monitored with a video microscope and flow-pressure sensor. The area under the curve (extent of thrombogenesis or thrombolysis) at 30 minutes was 69.9% lower in the edaravone-alteplase- than alteplase-treated group. The thrombolytic effect of alteplase was significantly attenuated in the presence of hydrogen peroxide, suggesting that oxidative stress might hinder thrombolysis. D-dimers were measured to evaluate these effects in human platelet-poor plasma samples. Although hydrogen peroxide significantly decreased the elevation of D-dimers by alteplase, edaravone significantly inhibited the decrease. Edaravone enhances alteplase-mediated thrombolysis, likely by preventing oxidative stress, which inhibits fibrinolysis by alteplase in thrombi.

    DOI: 10.1155/2017/6873281

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  • Hosokawa K, Ohnishi-Wada T, Sameshima-Kaneko H, Nagasato T, Miura N, Kikuchi K, Koide T,Maruyama I, Urano T. .  Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model .  Thromb Res.146   69 - 75   2016.9Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber modelReviewed

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  • 山﨑 裕毅, 川畑 貴裕, 澤  真理子, 賴 昱璋, 矢吹 映, 三浦 直樹 .  縦隔型T細胞性リンパ腫を呈した若齢犬の1例 .  日本獣医師会雑誌 69 ( 6 ) 333 - 338   2016.8縦隔型T細胞性リンパ腫を呈した若齢犬の1例Reviewed

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  • 藤川 拓郎, 永野 理樹, 和田 三枝, 齋藤 靖生, 乙丸 孝之介, 三浦 直樹, 藤木 誠, 窪田 力 .  娩出時肋骨骨折に起因した気管狭窄による呼吸不全子牛の8症例. .  日本獣医師会雑誌 69 ( 5 ) 267 - 270   2016.6娩出時肋骨骨折に起因した気管狭窄による呼吸不全子牛の8症例.Reviewed

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  • 山崎 裕毅, 川畑 貴裕, 澤 真理子, 頼 いく璋, 矢吹 映, 三浦 直樹 .  縦隔型T細胞性リンパ腫を呈した若齢犬の1例 .  日本獣医師会雑誌69 ( 6 ) 333 - 338   2016.6縦隔型T細胞性リンパ腫を呈した若齢犬の1例Reviewed International journal

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    胸水と呼吸困難を主訴に10ヵ月齢、未避妊雌のミニチュアダックスが鹿児島大学附属動物病院を受診した。CT検査より、造影増強された前縦隔の腫瘤性病変と肝腫大が描出された。その後の細針生検とクロナリティー検査から肝浸潤を呈した縦隔型T細胞性リンパ腫と診断した。本疾患に対して多剤併用療法(UW-25)を試みたが、治療効果が得られなかった。そこで、腫瘍検体を定量性PCRによる遺伝子解析に供したところ、多剤耐性因子(ABCB1とABCG2)及び血管新生因子受容体(VEGFR2とPDGFRα)の遺伝子発現量が高値を示したため、VEGFR2とPDGFRαを治療標的因子と判断し、リン酸トセラニブとCCNUによる救済療法を開始した。その結果、腫瘍縮小がみられ、一般状態も良好に維持できたが、初診から36日目に呼吸困難を呈し、自宅で斃死した。死後の剖検より、T細胞性リンパ腫が確定された。(著者抄録)

  • 川口 博明, 笹竹 洋, 野口 倫子, 秋岡 幸兵, 三浦 直樹, 武石 嘉一朗, 堀内 正久, 谷本 昭英 .  犬の輸送ストレス軽減のための新規鍼治療の試み. .  日本獣医師会雑誌 69 ( 3 ) 143 - 146   2016.4犬の輸送ストレス軽減のための新規鍼治療の試み.Reviewed

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  • Morishita S, Kawaguchi H, Ono T, Miura N, Murakoshi M, Sugiyama K, Kato H, Tanimoto A, Nishino H. .  Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs. .  Biosci Biotechnol Biochem.80 ( 2 ) 295 - 303   2016.2Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs.Reviewed

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  • Morishita Satoru, Kawaguchi Hiroaki, Ono Tomoji, Miura Naoki, Murakoshi Michiaki, Sugiyama Keikichi, Kato Hisanori, Tanimoto Akihide, Nishino Hoyoku .  マイクロミニブタにおいて、腸溶性ラクトフェリンは高脂肪高コレステロール食による高コレステロール血症と粥状動脈硬化症の進行を減弱させる(Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs) .  Bioscience, Biotechnology, and Biochemistry80 ( 2 ) 295 - 303   2016.2マイクロミニブタにおいて、腸溶性ラクトフェリンは高脂肪高コレステロール食による高コレステロール血症と粥状動脈硬化症の進行を減弱させる(Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs)Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:(公社)日本農芸化学会  

    マイクロミニブタに8週間腸溶性ラクトフェリン(eLF)を経口摂取させたところ、高脂肪高コレステロール食(HFCD)による血清の総コレステロール値とLDL-コレステロール値の上昇が著しく減弱したが、HDL-コレステロールは変化しなかった。血管の組織検査より、eLFにより全身の粥状動脈硬化の進行が阻害されていた。eLF投与に特徴的な肝臓の遺伝子による経路分析では、ステロイド生合成経路に有意な変化が起こり、これらの遺伝子はすべて上方制御されていた。すなわち、HFCDにより阻害されたコレステロール合成がeLFにより回復したことが示唆された。以上より、eLFはHFCDによるコレステロール代謝異常からホメオスタシスを防御することにより、高コレステロール血症と粥状動脈硬化症を防ぐことが示唆された。

  • 山崎 裕毅, 川畑 貴裕, 頼 いく璋, 三浦 直樹 .  症例から学ぶシリーズ 縦隔型T細胞性リンパ腫を呈した若齢犬の1例 .  Joncol: Japanese Journal of Veterinary Clinical Oncology12 ( 1 ) 99 - 102   2016.1症例から学ぶシリーズ 縦隔型T細胞性リンパ腫を呈した若齢犬の1例Reviewed International journal

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  • KAWAGUCHI Hiroaki, SASATAKE Yo, NOGUCHI Michiko, AKIOKA Kohei, MIURA Naoki, TAKEISHI Ka-ichiro, HORIUCHI Masahisa, TANIMOTO Akihide .  Study of a Novel Acupuncture Treatment for Canine Transportation Stress .  Journal of the Japan Veterinary Medical Association69 ( 3 ) 143 - 146   2016Reviewed International journal

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    In recent years, animals are increasingly being transported by vehicle. The mitigation of stress animals aresubjected to while being transported by vehicle is desirable from the perspective of animal welfare. Weinvestigated the potential of acupuncture, which has fewer side effects than drug therapy, as a means fortreating canine transportation stress. Eleven dogs which had exhibited motion sickness symptoms duringtransportation (vomiting, salivation, and a reduced amount of spontaneous activity) underwent an easy-to-applyacupuncture treatment. Short, ultra-thin circular transdermal needles were applied to locations correspondingto acupoints on the apical area of both ears, which are identified as Erjian Points 1 to 3 (“Jisen” in Japanese) intraditional oriental medicine. Motion sickness symptoms were suppressed in the treated dogs the next timethey were transported. We consider acupuncture to be a promising potential therapeutic strategy in veterinarymedicine.

    DOI: 10.12935/jvma.69.143

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J01104&link_issn=&doc_id=20160318440004&doc_link_id=10.12935%2Fjvma.69.143&url=https%3A%2F%2Fdoi.org%2F10.12935%2Fjvma.69.143&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • YAMAZAKI Hiroki, KAWABATA Takahiro, SAWA Mariko, LAI Yu-Chang, YABUKI Akira, MIURA Naoki .  A Rare Case of Mediastinal T-Cell Lymphoma in a Juvenile Dog .  Journal of the Japan Veterinary Medical Association69 ( 6 ) 333 - 338   2016Reviewed International journal

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    Mediastinal mass and hepatomegaly were detected by computed tomography in a 10-month-old Miniature Dachshund presenting with dyspnea. The dog was diagnosed as mediastinal T-cell lymphoma with liver invasion by cytological and clonality examination. Multidrug therapy (UW-25) was not effective for the dog. As a second-line therapy, a combination treatment of toceranib phosphate and CCNU was performed based on the expression profiling of multidrug resistance genes and angiogenic genes by qRT-PCR analysis, resulting in an improved condition. However, the dog died from dyspnea at 36 days after first examination. T-cell lymphoma was confirmed by necropsy.

    DOI: 10.12935/jvma.69.333

  • FUJIKAWA Takuro, NAGANO Masaki, WADA Mie, SAITOU Yasuo, OTOMARU Kounosuke, MIURA Naoki, FUJIKI Makoto, KUBOTA Chikara .  Consideration of Diagnosis and Surgical Treatment of Tracheal Stenosis Caused by Rib Fracture in Calves .  Journal of the Japan Veterinary Medical Association69 ( 5 ) 267 - 270   2016Reviewed International journal

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    Eight Japanese black calves (14‐65 days old) with severe respiration insufficiency due to tracheal stenosis by rib fractures at the calving were brought to Kagoshima University Veterinary Teaching Hospital. At the first visit (NOSAI), all calves had common symptoms of coughing and wheezing sounds. All calves were towed at the time of calving. In x-ray and computed-tomography (CT) examinations, the 1st to 6th right and/or left ribs were fractured and tracheal stenosis was observed. Surgical treatment was conducted in all cases to remove the 1st to 3rd fractured ribs on one side that compressed the trachea. The respiratory condition of all calves improved from the day after surgical relocation and had completely reversed by the 14th postoperative day. From the above, CT examination was found to be useful for diagnosing tracheal stenosis due to rib fracture while removing the fractured ribs on one side is effective surgical treatment.

    DOI: 10.12935/jvma.69.267

  • MATSUNAGA Fumi, YAMAZAKI Hiroki, TOKUNAGA Satoshi, SOGAWA Takeshi, SETOGUCHI Asuka, MIURA Naoki .  Two Cases of Primary Soft Tissue Lymphoma with Inflammation in Cats .  Journal of the Japan Veterinary Medical Association69 ( 12 ) 741 - 746   2016Reviewed International journal

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    <p>Primary soft tissue lymphoma (STL) was diagnosed using a punch biopsy in two cats with swelling and pain of the forelimb. When CT and MRI scans were used on one of two cats, the localization of the lesions could be clearly visualized. Chemotherapy was given to the two cats based on the detection of massive and invasive lesions during the examination of the imaging. However, the two cats finally died from hyperammonemia and poor conditions from adverse effects within a short period after treatment. It is difficult to distinguish STL from post-traumatic inflammation in cats because of the striking similarity of the clinical symptoms. Therefore, the study suggested that an open biopsy should be required for a definitive diagnosis and precise early treatment.</p>

    DOI: 10.12935/jvma.69.741

  • Kohyama M, Yabuki A, Kawasaki Y, Kawaguchi H, Miura N, Kitano Y, Onitsuka T, Rahman MM,Miyoshi N, Yamato O. .  GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog. .  J Am Anim Hosp Assoc51 ( 6 ) 396 - 400   2015.11GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog.Reviewed

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  • Otomaru K, Fujikawa T, Saito Y, Ando T, Obi T, Miura N, Kubota C. .  Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography .  Journal of Veterinary Medical Science. 77 ( 9 ) 1191 - 1193   2015.9Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomographyReviewed

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  • Otomaru Konosuke, Fujikawa Takuro, Saito Yasuo, Ando Takaaki, Obi Takeshi, Miura Naoki, Kubota Chikara .  未経産牛における腹腔内嚢胞のコンピュータ断層撮影による診断(Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography) .  The Journal of Veterinary Medical Science77 ( 9 ) 1191 - 1193   2015.9未経産牛における腹腔内嚢胞のコンピュータ断層撮影による診断(Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography)Reviewed International journal

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  • Noguchi M, Miura N, Ando T, Kubota C, Hobo S, Kawaguchi H, Tanimoto A. .  Profiles of reproductive hormone in the microminipig during the normal estrous cycle. .  In Vivo29 ( 1 ) 17 - 22   2015.1Profiles of reproductive hormone in the microminipig during the normal estrous cycle.Reviewed

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  • Murata D, Miyakoshi D, Hatazoe T, Miura N, Tokunaga S, Fujiki M, Nakayama K, Misumi K. .  Multipotency of equine mesenchymal stem cells derived from synovial fluid. .  Vet J.202 ( 1 ) 53 - 61   2014.10Multipotency of equine mesenchymal stem cells derived from synovial fluid.Reviewed

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  • Kawaguchi H, Yamada T, Miura N, Ayaori M, Uto-Kondo H, Ikegawa M, Noguchi M, Wang KY, Izumi H, Tanimoto A. .  Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet. .  J Atheroscler Thromb21 ( 3 ) 186 - 203   2014.3Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet.Reviewed

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  • Murata D. Sogawa T. Tokunaga S. Iwanaga T. Kawaguchi H. Miyoshi N. Momoi Y. Fujiki M. Miura N*(*Corresponding author). .  Ganglion cysts arising from a canine stifle joint. .  J Vet Med Sci76 ( 3 ) 457 - 459   2014.3 Ganglion cysts arising from a canine stifle joint.Reviewed

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  • Kawaguchi Hiroaki, Yamada Tomonobu, Miura Naoki, Ayaori Makoto, Uto-Kondo Harumi, Ikegawa Masaya, Noguchi Michiko, Wang Ke-Yong, Izumi Hiroyuki, Tanimoto Akihide .  高脂肪/高コレステロール食を与えた世界最小のマイクロミニブタにおける動脈硬化の急速な進行 そのサイズとヒトの病態生理学との類似性ゆえに有用な動物モデル(Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet: A Useful Animal Model Due to its Size and Similarity to Human Pathophysiology) .  Journal of Atherosclerosis and Thrombosis21 ( 3 ) 186 - 203   2014.3高脂肪/高コレステロール食を与えた世界最小のマイクロミニブタにおける動脈硬化の急速な進行 そのサイズとヒトの病態生理学との類似性ゆえに有用な動物モデル(Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet: A Useful Animal Model Due to its Size and Similarity to Human Pathophysiology)Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:(一社)日本動脈硬化学会  

    生後3ヵ月で体重が僅か5kgの世界最小のマイクロミニブタ(MMP)を用いて脂質異常症誘発性動脈硬化の動物モデルを開発し、脂質代謝とアテローム形成に関するヒトとの類似性について調べた。MMPにコール酸以外のコレステロールを0.2%以上含む高脂肪/高コレステロール食を8週間与えたところ、高コレステロール血症となり、動脈硬化を発症した。血清のLDL-C値とLDL画分の割合は著しく増加し、LDL受容体とHMG-CoA還元酵素の肝発現は協調的に減少した。MMPの血清よりコレステロール輸送に逆の働きを及ぼすコレステリルエステル転送蛋白質活性を検出した。Niemann-Pick C1様1蛋白は肝臓と小腸で発現したが、肝性apoB mRNA編集酵素は発現しなかった。ヒトと同様、そしてマウスとは対照的に、肝性リパーゼ活性の大半は肝臓に局在していた。

  • Murata Daiki, Sogawa Takeshi, Tokunaga Satoshi, Iwanaga Tomoko, Kawaguchi Hiroaki, Miyoshi Noriaki, Momoi Yasuyuki, Fujiki Makoto, Miura Naoki .  犬の後膝関節に生じたガングリオン嚢胞(Ganglion Cysts Arising from a Canine Stifle Joint) .  The Journal of Veterinary Medical Science76 ( 3 ) 457 - 459   2014.3犬の後膝関節に生じたガングリオン嚢胞(Ganglion Cysts Arising from a Canine Stifle Joint)Reviewed International journal

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  • Akioka K, Kawaguchi H, Kitajima S, Miura N, Noguchi M, Horiuchi M, Miyoshi N, Tanimoto A. .  Investigation of necessity of sodium cholate and minimal required amount of cholesterol for dietary induction of atherosclerosis in microminipigs. .  In Vivo28 ( 1 ) 81 - 90   2014.1Investigation of necessity of sodium cholate and minimal required amount of cholesterol for dietary induction of atherosclerosis in microminipigs.Reviewed

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  • Hosokawa K. Ohnishi T. Sameshima H. Miura N. Koide T. Maruyama I. Tanaka KA. .  Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model. .  PLoS One9 ( 1 ) e86491   2014.1Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model.Reviewed

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  • Hosokawa K. Ohnishi T. Miura N. Sameshima H. Koide T. Tanaka KA. Maruyama I. .  Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions. .  Thromb Res133 ( 1 ) 66 - 72   2014.1Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions.Reviewed

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  • Md Zahorul Islam, Emi Yamazaki-Himeno, Mitsuya Shiraishi, Atsushi Miyamoto, Hiroaki Kawaguchi, Noriaki Miyoshi, Naoki Miura, Akihide Tanimoto .  Angiotensin II decreases bradykinin-induced NO and increases prostaglandin F-2 alpha release from cultured Microminipig basilar arterial endothelial cells .  JOURNAL OF PHARMACOLOGICAL SCIENCES124   104P - 104P   2014Angiotensin II decreases bradykinin-induced NO and increases prostaglandin F-2 alpha release from cultured Microminipig basilar arterial endothelial cellsReviewed International journal

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  • Kawaguchi, H., Yamada, T., Miura, N., Ayaori, M., Uto-Kondo, H., Ikegawa, M., Noguchi, M., Wang, K.-Y., Izumi, H., Tanimoto, A. .  Rapid development of atherosclerosis in the world's smallest microminipig fed a high-fat/high-cholesterol diet: A useful animal model due to its size and similarity to human pathophysiology .  Journal of Atherosclerosis and Thrombosis21 ( 3 ) 186 - 203   2014Reviewed International journal

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    Aim: Experimental studies of human atherogenesis require an appropriate animal model that mimics human physiology and pathology. Because swine physiology is similar to human physiology, we developed a hyperlipidemia-induced atherosclerosis model using the recently developed world's smallest Microminipig (TM).
    Methods: These animals weigh only 5 kg at 3 months of age, much smaller than any other miniature pig. We found that the administration of a high-fat/high-cholesterol diet containing at least 0.2% cholesterol without cholic acid for as little as eight weeks induces hypercholesterolemia and subsequent atherosclerosis in these animals.
    Results: The serum levels of low-density lipoprotein cholesterol (LDL-C) and the percent distribution of cholesterol in the LDL fractions were markedly increased. The hepatic expression of LDL receptor and hydroxymethylglutaryl-CoA reductase was coordinately decreased. The cholesteryl ester transfer protein activity, which plays a role in reverse cholesterol transport, was detected in the serum of the Microminipigs. Niemann-Pick C1-like 1 protein was expressed in both the liver and small intestine; however, hepatic apoB mRNA editing enzyme was not expressed. As in humans, and in contrast to that observed in mice, most of the hepatic lipase activity was localized in the liver. These results suggest that the hyperlipidemia-induced gene expression profile linked to cholesterol homeostasis and atherogenesis is similar in Microminipigs and humans.
    Conclusion: We conclude that the characteristics of the Microminipig, including its easy handling size, make it an appropriate model for studies of atherosclerosis and related conditions.

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  • Tasaki Yumi, Miura Naoki, Iyori Keita, Nishifuji Koji, Endo Yasuyuki, Momoi Yasuyuki .  バベシア症の犬における血管炎様変化を伴う全身脱毛症(Generalized Alopecia with Vasculitis-Like Changes in a Dog with Babesiosis) .  The Journal of Veterinary Medical Science75 ( 10 ) 1367 - 1369   2013.10バベシア症の犬における血管炎様変化を伴う全身脱毛症(Generalized Alopecia with Vasculitis-Like Changes in a Dog with Babesiosis)Reviewed International journal

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  • Miura N, Furukawa M, Magari Y, Momoi Y. .  Cross-Reactivity of the Anti-Human D-Dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products. .  J Vet Med Sci.75 ( 7 ) 963 - 966   2013.7Cross-Reactivity of the Anti-Human D-Dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products.Reviewed

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  • Miura Naoki, Furukawa Makoto, Magari Yasuo, Momoi Yasuyuki .  抗ヒトDダイマーモノクローナル抗体1C9-6F10の犬フィブリン分解産物との交差反応性(Cross-Reactivity of the Anti-Human D-dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products) .  The Journal of Veterinary Medical Science75 ( 7 ) 963 - 966   2013.7抗ヒトDダイマーモノクローナル抗体1C9-6F10の犬フィブリン分解産物との交差反応性(Cross-Reactivity of the Anti-Human D-dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products)Reviewed International journal

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  • Kawaguchi H*, Yamada T*, Miura N(* Equal contribution), Noguchi M, Izumi H, Miyoshi N, Tanimoto A. .  Sex Differences in Serum Lipid Profile in Novel Microminipigs. .  In Vivo.27 ( 5 ) 617 - 621   2013.5Sex Differences in Serum Lipid Profile in Novel Microminipigs.Reviewed

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  • Miura N, Kawaguchi H, Nagasato T, Yamada T, Ito T, Izumi H, Shameshima H, Miyoshi N, Tanimoto A, Maruyama I .  Coagulation activity and white thrombus formation in the microminipig. .  In vivo27 ( 3 ) 357 - 361   2013.5Coagulation activity and white thrombus formation in the microminipig. Reviewed

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  • 岩永朋子, 関屋仁, 三浦直樹, 桃井康行. .  咳嗽失神が認められた犬の1例. .  鹿児島県獣医師会会報52   21 - 22   2013.1 咳嗽失神が認められた犬の1例.

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  • Yoshikawa T, Takahashi Y, Kawaguchi H, Utsunomiya S, Miura N, Izumi H, Miyoshi N, Tanimoto A. .  A dermal phototoxicity study following intravenous infusion administration of ciprofloxacin hydrochloride in the novel microminipigs. .  Toxicologic pathology41 ( 1 ) 109 - 113   2013.1A dermal phototoxicity study following intravenous infusion administration of ciprofloxacin hydrochloride in the novel microminipigs.Reviewed

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  • Hosokawa K, Ohnishi T, Sameshima H, Miura N, Ito T, Koide T, Maruyama I. .  nalysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions. .  Thromb Haemost109 ( 1 ) 102 - 111   2013.1nalysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions.Reviewed

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  • Kikuchi K, Miura N, Kawahara KI, Murai Y, Morioka M, Lapchak PA, Tanaka E .  Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke. .  Biomedical reports1 ( 1 ) 7 - 12   2013.1Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke.Reviewed International journal

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  • Tasaki Y, Miura N, Iyori K, Nishifuji K, Endo Y, Momoi Y .  Generalized Alopecia with Vasculitis-Like Changes in a Dog with Babesiosis. .  J Vet Med Sci75 ( 10 ) 1367 - 1369   2013Generalized Alopecia with Vasculitis-Like Changes in a Dog with Babesiosis. Reviewed

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  • Tasaki Yumi, Ito Genta, Miura Naoki, Tanaka Miho, Momoi Yasuyuki .  Predisposing cause and prevention of canine silica urolithiasis .  Journal of Pet Animal Nutrition16 ( 2 ) 61 - 66   2013Reviewed International journal

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    Previously, we reported that Kagoshima, Japan, is an endemic area of canine silica urolithiasis. Tap water in Kagoshima contains significantly greater silica concentrations than other areas of Japan. Ingestion of silica from tap water may lead to the formation of silica uroliths in dogs. We measured the concentration of silica in tap water from various areas of Japan. Concentrations were higher in the city of Takeda(Oita prefecture) and in some areas around the city of Chikusei(Ibaraki prefecture). Fast atom bombardment mass spectrometry analysis of water from Kirishima(Kagoshima prefecture)revealed that the character of water was similar to that after silica sintering. Removal of silica from tap water may decrease the risk of silica urolithiasis in dogs. We demonstrated that silica could be successfully removed from tap water with a reverse osmosis membrane water filter but not with a typical domestic water filter. We also sent internet-based questionnaires to owners of dogs with silica uroliths to investigate other possible etiologies of silica urolithiasis. The results revealed that the specific pet food brand may be related to silica urolithiasis. However, the concentration of total silica in pet food does not appear to be related to the formation of uroliths.

    DOI: 10.11266/jpan.16.61

  • Kikuchi, K., Tancharoen, S., Ito, T., Morimoto-Yamashita, Y., Miura, N., Kawahara, K.-i., Maruyama, I., Murai, Y., Tanaka, E. .  Potential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke .  International Journal of Molecular Sciences14 ( 9 ) 18899 - 18924   2013Reviewed International journal

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    Stroke is a major cause of mortality and disability worldwide. The main cause of stroke is atherosclerosis, and the most common risk factor for atherosclerosis is hypertension. Therefore, antihypertensive treatments are recommended for the prevention of stroke. Three angiotensin receptor blockers (ARBs), telmisartan, irbesartan and candesartan, inhibit the expression of the receptor for advanced glycation end-products (RAGE), which is one of the pleiotropic effects of these drugs. High mobility group box 1 (HMGB1) is the ligand of RAGE, and has been recently identified as a lethal mediator of severe sepsis. HMGB1 is an intracellular protein, which acts as an inflammatory cytokine when released into the extracellular milieu. Extracellular HMGB1 causes multiple organ failure and contributes to the pathogenesis of hypertension, hyperlipidemia, diabetes mellitus, atherosclerosis, thrombosis, and stroke. This is the first review of the literature evaluating the potential of three ARBs for the HMGB1-RAGE axis on stroke therapy, including prevention and acute treatment. This review covers clinical and experimental studies conducted between 1976 and 2013. We propose that ARBs, which inhibit the HMGB1/RAGE axis, may offer a novel option for prevention and acute treatment of stroke. However, additional clinical studies are necessary to verify the efficacy of ARBs.

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  • Miyamoto Atsushi, Islam Md. Zahorul, Kawaguchi Hiroaki, Miura Naoki, Yamzaki-Himeno Emi, Shiraishi Mitsuya, Miyoshi Noriaki, Tanimoto Akihide .  Effect of continuous intravenous infusion of angiotensin II on Microminipig basilar arterial responsiveness .  JOURNAL OF PHARMACOLOGICAL SCIENCES121   22P   2013Effect of continuous intravenous infusion of angiotensin II on Microminipig basilar arterial responsivenessReviewed International journal

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  • Hosokawa, K., Ohnishi, T., Sameshima, H., Miura, N., Ito, T., Koide, T., Maruyama, I. .  Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions .  Thrombosis and Haemostasis109 ( 1 ) 102 - 111   2013Reviewed International journal

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    High residual platelet aggregability and circulating platelet-monocyte aggregates in patients administered aspirin and clopidogrel are associated with ischaemic vascular events. To determine the relevance of these factors with residual thrombogenicity, we measured platelet thrombus formation using a microchip-based flow-chamber system in cardiac patients receiving aspirin and/or clopidogrel, and evaluated its correlation with agonist-inducible platelet aggregation and platelet-monocyte aggregates. Platelet thrombus formation was analysed by measuring flow pressure changes due to the occlusion of micro-capillaries and was quantified by calculating AUC(10) (area under the flow pressure curve). The growth and stability of platelet thrombi that formed inside microchips at shear rates of 1000, 1500, and 2000 s(-1) were markedly reduced in patients receiving aspirin and/or thienopyridine compared to healthy controls (n=33). AUC(10) values of aspirin therapy patients (n=20) were significantly lower and higher than those of healthy controls and dual antiplatelet therapy patients (n=19), respectively, and showed relatively good correlations with collagen-induced platelet aggregation and platelet-monocyte aggregates at 1000 and 1500 s(-1) (r(s)&gt;0.59, p&lt;0.01). In contrast, AUC(10) in dual antiplatelet therapy patients was significantly correlated with ADP-induced platelet aggregation at all examined shear rates (r(s)&gt;0.59, p&lt;0.01), but did not correlate with collagen-induced aggregation. Aspirin monotherapy patients with high residual platelet thrombogenicity also exhibited significant elevations in both collagen-induced platelet aggregation and platelet-monocyte aggregates. Our results, although preliminary, suggest that residual platelet thrombogenicity in aspirin-treated patients is associated with either collagen-induced platelet aggregation or circulating platelet-monocyte aggregates, but it is predominantly dependent on ADP-induced platelet aggregation in patients receiving dual antiplatelet therapy.

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  • 濱田 亜衣, 三浦 直樹, 桃井 康行 .  犬の中枢性リンパ腫の遺伝子診断 .  MVM21 ( 7 ) 45 - 48   2012.11犬の中枢性リンパ腫の遺伝子診断Reviewed International journal

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  • Iwanaga T, Miura N, Miyoshi N, Endo Y, and Momoi Y. .  Abnormal Erythroid Cell Proliferation and Myelofibrosis in a Cat. .  J Vet Med Sci74 ( 7 ) 909 - 912   2012.7Abnormal Erythroid Cell Proliferation and Myelofibrosis in a Cat. Reviewed

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  • Kawaguchi H, Yamada T, Miura N, Takahashi Y, Yoshikawa T, Izumi H, Kawarasaki T, Miyoshi N, and Tanimoto A. .  Reference Values of Hematological and Biochemical Parameters for the World Smallest Microminipigs. .  J Vet Med Sci74 ( 7 ) 933 - 936   2012.7Reference Values of Hematological and Biochemical Parameters for the World Smallest Microminipigs.Reviewed

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  • Murata D, Miura N*,(*Corresponding author), Iwanaga T, Tokunaga S, Miyoshi N, Kitano Y, Momoi Y, and Fujiki M, .  CT and MRI Imaging Diagnosis of Epidural Idiopathic Sterile Pyogranulomatous Inflammation in a Dog Spinal Canal. .  J Vet Med Sci74 ( 7 ) 913 - 915   2012.7CT and MRI Imaging Diagnosis of Epidural Idiopathic Sterile Pyogranulomatous Inflammation in a Dog Spinal Canal.Reviewed

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  • Murata Daiki, Miura Naoki, Iwanaga Tomoko, Tokunaga Satoshi, Miyoshi Noriaki, Kitano Yoshiaki, Momoi Yasuyuki, Fujiki Makoto .  イヌ脊柱管における硬膜外特発性無菌性化膿性肉芽腫性炎症のCTおよびMRIイメージング診断(CT and MRI Imaging Diagnosis of Epidural Idiopathic Sterile Pyogranulomatous Inflammation in a Dog Spinal Canal) .  The Journal of Veterinary Medical Science74 ( 7 ) 913 - 915   2012.7イヌ脊柱管における硬膜外特発性無菌性化膿性肉芽腫性炎症のCTおよびMRIイメージング診断(CT and MRI Imaging Diagnosis of Epidural Idiopathic Sterile Pyogranulomatous Inflammation in a Dog Spinal Canal)Reviewed International journal

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  • Kawaguchi Hiroaki, Yamada Tomonobu, Miura Naoki, Takahashi Yoshihiro, Yoshikawa Tsuyoshi, Izumi Hiroyuki, Kawarasaki Tatsuo, Miyoshi Noriaki, Tanimoto Akihide .  世界最小ミニブタにおける血液学的および生化学的パラメーターの基準値(Reference Values of Hematological and Biochemical Parameters for the World Smallest Microminipigs) .  The Journal of Veterinary Medical Science74 ( 7 ) 933 - 936   2012.7世界最小ミニブタにおける血液学的および生化学的パラメーターの基準値(Reference Values of Hematological and Biochemical Parameters for the World Smallest Microminipigs)Reviewed International journal

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  • Iwanaga Tomoko, Miura Naoki, Miyoshi Noriaki, Endo Yasuyuki, Momoi Yasuyuki .  ネコにおける異常赤血球系細胞増殖と骨髄線維症(Abnormal Erythroid Cell Proliferation and Myelofibrosis in a Cat) .  The Journal of Veterinary Medical Science74 ( 7 ) 909 - 912   2012.7ネコにおける異常赤血球系細胞増殖と骨髄線維症(Abnormal Erythroid Cell Proliferation and Myelofibrosis in a Cat)Reviewed International journal

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  • 田崎 由実, 三浦 直樹, 桃井 康行 .  鹿児島県で多発するイヌのシリカ尿石についての緊急調査 .  ペット栄養学会誌15 ( 1 ) 7 - 11   2012.4鹿児島県で多発するイヌのシリカ尿石についての緊急調査Reviewed International journal

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    シリカ結石はイヌではまれな尿石とされている。今回、我々は鹿児島県を中心にシリカ尿結石について疫学調査を行った。その結果、鹿児島県内の獣医師やオーナーに対するアンケート調査において、鹿児島県を中心とする地域でシリカ尿結石が多くみられ、その発生の要因として飲料水との関係が示唆された。そこで鹿児島県内の水道水中のシリカ濃度を測定したところ、他地域と比較して著しく高値を示した。またミネラルウォーターについても同様に、鹿児島県が採水地の製品でシリカ濃度が高値のものがあった。実験的にシリカを高濃度に含む水道水の飲水により尿中シリカ濃度の上昇は見られなかったが、疫学調査から、シリカ濃度の低い水を飲水として使用することがシリカ結石発生の予防となると推測した。(著者抄録)

  • 三浦 直樹 .  大学病院の二次診療 鹿児島大学農学部附属動物病院<第1回> 当施設における画像診断科の状況ならびにダイナミックCT造影検査の症例紹介 .  CLINIC NOTE8 ( 2 ) 90 - 94   2012.2大学病院の二次診療 鹿児島大学農学部附属動物病院<第1回> 当施設における画像診断科の状況ならびにダイナミックCT造影検査の症例紹介Reviewed International journal

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  • 田崎 由実, 伊藤 源太, 三浦 直樹, 桃井 康行 .  犬のシリカ尿結石好発地域におけるシリカ結石の成因と予防方法 .  ペット栄養学会誌15 ( 0 ) Suppl_44 - Suppl_45   2012Reviewed International journal

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    シリカ結石はイヌでは比較的まれな尿石とされている。昨年の本学会で、我々は鹿児島県ではシリカ尿結石が多くみられることを報告した。そして、鹿児島県内の水道水中のシリカ濃度は他の地域に較べ著しく高く、シリカ結石発生の要因として飲料水との関係を示唆した。しかし、新たな謎も生じた。鹿児島市内の水道水のシリカ濃度は比較的高いのになぜシリカ結石がほとんど生じないか、シリカの好発地帯ではみな同じ水を飲んでいるのにもかかわらずなぜ一部の犬でシリカ結石が生じるのか、さらに、シリカ好発地域以外では何が原因でシリカ結石が発症するのか、などである。今回はそれらの謎に答えるため各種実験を行い、シリカ発生の機序とその予防法について考察した。

    DOI: 10.11266/jpan.15.Suppl_44

  • Tasaki Yumi, Miura Naoki, Momoi Yasuyuki .  Silica urolithiasis in dogs around in Kagoshima .  Journal of Pet Animal Nutrition15 ( 1 ) 7 - 11   2012Reviewed International journal

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    Silica calculus is unusual in urolithiasis in dogs. We conducted epidemiological study on silica calculus in dogs around Kagoshima area. Information questionnaires from veterinarians and clients indicated that silica urolithiasis was not related to food and dog's habit (eating clod), but was associated with drinking tap water. Silica concentration of tap water in Kagoshima area was obviously higher than that in another area in Japan. A brand of mineral water made in Kagoshima area also had high silica level. Though intake of high level silica in water did not affect urine silica concentration experimentally, our results indicated that it is beneficial to use low silica level water to prevent silica urolithiasis in dogs.

    DOI: 10.11266/jpan.15.7

  • Kikuchi, K., Takeshige, N., Miura, N., Morimoto, Y., Ito, T., Tancharoen, S., Miyata, K., Kikuchi, C., Iida, N., Uchikado, H., Miyagi, N., Shiomi, N., Kuramoto, T., Maruyama, I., Morioka, M., Kawahara, K.-I. .  Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review) .  Experimental and Therapeutic Medicine3 ( 1 ) 3 - 8   2012Reviewed International journal

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    Free radicals play an important role in the pathogenesis of a variety of diseases; thus, they are an attractive target for therapeutic intervention in these diseases. Compounds capable of scavenging free radicals have been developed for this purpose and some, developed for the treatment of cerebral ischemic stroke, have progressed to clinical trials. One such scavenger, edaravone, is used to treat patients within 24 h of stroke. Edaravone, which can diffuse into many disease-affected organs, also shows protective effects in the heart, lung, intestine, liver, pancreas, kidney, bladder and testis. As well as scavenging free radicals, edaravone has antiapoptotic, anti-necrotic and anti-cytokine effects in various diseases. Here, we critically review the literature on its clinical efficacy and examine whether edaravone should be considered a candidate for worldwide development, focusing on its effects on diseases other than cerebral infarction. Edaravone has been safely used as a free radical scavenger for more than 10 years; we propose that edaravone may offer a novel treatment option for several diseases.

    DOI: 10.3892/etm.2011.352

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  • KIKUCHI KIYOSHI, KAWAHARA KO-ICHI, MATSUDA FUMIYO, ITO TAKASHI, MORIMOTO YOKO, TANCHAROEN SALUNYA, MIURA NAOKI, TAKESHIGE NOBUYUKI, ORITO KIMIHIKO, YAMASHITA SHIN, UCHIKADO HISAAKI, MIYAGI NAOHISA, SHIOMI NAOTO, KURAMOTO TERUKAZU, TOKUTOMI TAKASHI, SHIGEMORI MINORU, SAKAMOTO ROKUDAI, KIKUCHI CHIEMI, IIDA NARUMI, YOSHIDA YOSHIHIRO, HASHIGUCHI TERUTO, MARUYAMA IKURO, MORIOKA MOTOHIRO, TANAKA EIICHIRO .  Effect of edaravone on HMGB1 in neuronal cells under ischemic conditions .  Neurotraumatology34 ( 2 ) 225 - 227   2011.12Reviewed International journal

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    DOI: 10.32187/neurotraumatology.34.2_225

  • 西洋志、徳永暁、三浦直樹 .  ダイナミックCT撮影が診断・治療法の選択に有用であった犬の肝細胞癌の2例. .  鹿児島県獣医師会雑誌48   15 - 17   2011.10ダイナミックCT撮影が診断・治療法の選択に有用であった犬の肝細胞癌の2例.

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  • 岩永朋子, 三浦直樹, 新井恒, 桃井康行, 遠藤泰之. , 26(47): 22-24 (2011) .  ドキソルビシン投与後に心筋障害が原因と思われる不整脈が発症した2症例. .  鹿児島県獣医師会会報26 ( 47 ) 22 - 24   2011.10ドキソルビシン投与後に心筋障害が原因と思われる不整脈が発症した2症例.

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  • MURATA Daiki, MIURA Naoki, MATUMOTO Mitsuharu, MIYOSHI Nobuaki, FUJIKI Makoto, MISUMI Kazuhiro .  Diagnostic Imaging of Cervical Vertebral Injury in a Horse .  Journal of the Japan Veterinary Medical Association64 ( 9 ) 703 - 707   2011.9Reviewed International journal

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    An equine case of hind lameness and wobbler syndrome following an accidental forward fall during exercise was evaluated by diagnostic imaging. The myelography under general anesthesia was suggestive of a dorsally compressed spine between the sixth cervical vertebrae (C6) and C7. Histopathological findings also pointed to compression myelopathy between C6 and C7. A computed tomography scan of the cervical and thoracic (T) vertebraes following euthanasia was diagnostic of fractures of the C7 and joint space widening at the articular processes at the range from C6 to T2. Deformed alignment from C6 to T2 could induce spinal compression.

    DOI: 10.12935/jvma.64.703

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    Other Link: http://agriknowledge.affrc.go.jp/RN/2010814357

  • Kikuchi K, Uchikado H, Miyagi N, Morimoto Y, Ito T, Tancharoen S, Miura N, Miyata K, Sakamoto R, Kikuchi C, Iida N, Shiomi N, KuramotoT, Kawahara K. .  Beyond neurological disease: New targets for edaravone. .  Int J Mol Med. 28 ( 6 ) 899 - 906   2011.6Beyond neurological disease: New targets for edaravone.Reviewed

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  • Kikuchi K, Uchikado H, Miura N, Morimoto Y, Ito T, Tancharoen S, Miyata K, Sakamoto R, Kikuchi C, Iida N, Shiomi N, KuramotoT, Miyagi N, Kawahara K .  HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development. .  Exp Ther Med2 ( 5 ) 767 - 770   2011.5HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development.Reviewed

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  • 三浦直樹 .  ダイナミックCT造影検査による門脈体循環シャント症例の診断. .  鹿児島県獣医師会雑誌26 ( 1 ) 20 - 21   2011.3ダイナミックCT造影検査による門脈体循環シャント症例の診断.

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  • Kawaguchi H, Miyoshi N, Miura N, Fujiki M, Horiuchi M, Izumi Y, Miyajima H, Nagata R, Misumi K, Takeuchi T, Tanimoto A, Yoshida H .  Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet. .  J Pharmacol Sci.115 ( 2 ) 115 - 121   2011.2Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet.Reviewed

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  • Kikuchi K*, Miura N*, (*These authors are equally contributed.) Morimoto Y, Ito T, Tancharoen S, Miyata K, Kikuchi C, Iida N, Takeshige N, Uchikado H, Miyagi N, Shiomi N, KuramotoT, Hashiguchi T, Maruyama I, Morioka M, Kawahara K. .  Beneficial Effects of the Free Radical Scavenger Edaravone (Radicut) in Neurologic Diseases. .  J Neurol Neurophysiol 1 ( Special Issue 1 ) 1 - 5   2011.1Beneficial Effects of the Free Radical Scavenger Edaravone (Radicut) in Neurologic Diseases.Reviewed

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  • 田崎 由実, 三浦 直樹, 桃井 康行 .  鹿児島県で多発するイヌのシリカ結石についての報告 .  ペット栄養学会誌14 ( 0 ) Suppl_73 - Suppl_74   2011Reviewed International journal

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    シリカ結石はイヌではまれな尿石とされている。今回、我々は鹿児島県を中心にシリカ尿結石について疫学調査を行った。その結果、鹿児島県内の獣医師やオーナーに対するアンケート調査において、鹿児島県を中心とする地域でシリカ尿結石が多くみられ、その発生の要因として飲料水との関係が示唆された。そこで鹿児島県内の水道水中のシリカ濃度を測定したところ、他地域と比較して著しく高値を示した。またミネラルウォーターについても同様に、鹿児島県が採水地の製品でシリカ濃度が高値のものがあった。実験的にシリカを高濃度に含む水道水の飲水により尿中シリカ濃度の上昇は見られなかったが、疫学調査から、シリカ濃度の低い水を飲水として使用することがシリカ結石発生の予防となると推測した。

    DOI: 10.11266/jpan.14.Suppl_73

  • Meng, X., Kawahara, K.-I., Miyanohara, H., Yoshimoto, Y., Yoshinaga, K., Noma, S., Kikuchi, K., Morimoto, Y., Ito, T., Oyama, Y., Yoshinaga, N., Shrestha, B., Chandan, B., Mera, K., Tada, K.-I., Miura, N., Ono, Y., Takenouchi, K., Maenosono, R., Nagasato, T., Hashiguchi, T., Maruyama, I. .  1,5-anhydro-D-fructose: A natural antibiotic that inhibits the growth of gram-positive bacteria and microbial biofilm formation to prevent nosocomial infection .  Experimental and Therapeutic Medicine2 ( 4 ) 625 - 628   2011Reviewed International journal

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    Nosocomial infections caused by microbial opportunistic infections or microbial biofilms may occur during hospitalization and increase patient morbidity, mortality and health care costs. Artificial antibiotic agents were initially used to prevent infection; however, the high prevalence of nosocomial infections has resulted in their excessive use, which has led to microbial resistance to these agents. The increase in microbial resistance to antibiotics and the development of antibiotic agents may be the cause of the production of other microbial resistance. Thus, natural compounds that have no adverse side effects would be a preferred treatment modality. Recently, the monosaccharide 1,5-anhydro-D-fructose (1,5-AF), a natural plant compound derived from starch, has been found to have multifunctional properties, including antioxidant, antiplatelet aggregation by thrombin and anti-inflammatory activities. The results of the present study demonstrate that 1,5-AF suppressed the growth of coagulase-negative staphylococci on the hands as well as the growth of Staphylococcus epidermidis, which is a cause of opportunistic infections. Furthermore, 1,5-AF suppressed biofilm formation by the methicillin-resistant Staphylococcus aureus. In conclusion, 1,5-AF is a natural compound that may be effective in preventing nosocomial infections, without causing adverse side effects.

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  • Kikuchi, K., Kawahara, K.-I., Uchikado, H., Miyagi, N., Kuramoto, T., Miyagi, T., Morimoto, Y., Ito, T., Tancharoen, S., Miura, N., Takenouchi, K., Oyama, Y., Shrestha, B., Matsuda, F., Yoshida, Y., Arimura, S., Mera, K., Tada, K.-I., Yoshinaga, N., Maenosono, R., Ohno, Y., Hashiguchi, T., Maruyama, I., Shigemori, M. .  Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review) .  Experimental and Therapeutic Medicine2 ( 5 ) 771 - 775   2011Reviewed International journal

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    Edaravone was originally developed as a potent free radical scavenger and has been widely used to treat cerebral infarction in Japan since 2001. Several free radical scavengers have been developed and some of them have progressed to clinical trials for the treatment of cerebral infarction. One such scavenger, edaravone, has been approved by the regulatory authority in Japan for the treatment of patients with cerebral infarction. Of particular interest is the ability of edaravone to diffuse into the central nervous system in various neurologic diseases. Aside from its hydroxyl radical scavenging effect, edaravone has been found to have beneficial effects on inflammation, matrix metalloproteinases, nitric oxide production and apoptotic cell death. Concordantly, edaravone has been found to have neuroprotective effects in a number of animal models of disease, including stroke, spinal cord injury, traumatic brain injury, neurodegenerative diseases and brain tumors. The proven safety of edaravone following 9 years of use as a free radical scavenger suggests that it may have potential for development into an effective treatment of multiple neurologic conditions in humans.

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  • Kawaguchi Hiroaki, Miyoshi Noriaki, Miura Naoki, Horiuchi Masahisa, Ono Tomoji, Murakoshi Michiaki, Nishino Hoyoku, Nagata Ryoichi, Sahara Hisashi, Tanimoto Akihide, Yamada Kazuhiko, Yoshida Hiroki .  Microminipig: research models to break through cardiovascular disease .  JOURNAL OF PHARMACOLOGICAL SCIENCES115   49P   2011Microminipig: research models to break through cardiovascular diseaseReviewed International journal

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  • Kikuchi, K., Uchikado, H., Miura, N., Morimoto, Y., Ito, T., Tancharoen, S., Miyata, K., Sakamoto, R., Kikuchi, C., Iida, N., Shiomi, N., Kuramoto, T., Miyagi, N., Kawahara, K.-I. .  HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development (Review) .  Experimental and Therapeutic Medicine2 ( 5 ) 767 - 770   2011Reviewed International journal

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    Historically, clinical outcomes following spinal cord injury (SCI) have been dismal. Severe SCI leads to devastating neurological deficits, and there is no treatment available that restores the injury-induced loss of function to a degree that an independent life can be guaranteed. To address all the issues associated with SCI, a multidisciplinary approach is required, as it is unlikely that a single approach, such as surgical intervention, pharmacotherapy or cellular transplantation, will suffice. High mobility group box 1 (HMGB1) is an inflammatory cytokine. Various studies have shown that HMGB I plays a critical role in SCI and that inhibition of HMGB1 release may be a novel therapeutic target for SCI and may support spinal cord repair. In addition, HMGB1 has been associated with graft rejection in the early phase. Therefore, HMGB1 may be a promising therapeutic target for SCI transplant patients. We hypothesize that inhibition of HMGB1 release rescues patients with SCI. Taken together, our findings suggest that anti-HMGB1 monoclonal antibodies or short hairpin RNA-mediated HMGB1 could be administered for spinal cord repair in SCI patients.

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  • Kikuchi, K., Uchikado, H., Miyagi, N., Morimoto, Y., Takashi, I., Tancharoen, S., Miura, N., Miyata, K., Sakamoto, R., Kikuchi, C., Iida, N., Shiomi, N., Kuramoto, T., Kawahara, K.-I. .  Beyond neurological disease: New targets for edaravone (Review) .  International Journal of Molecular Medicine28 ( 6 ) 899 - 906   2011Reviewed International journal

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    Free radicals play major roles in the pathogenesis of tissue damage in many diseases and clinical conditions, and the removal of free radicals may offer a treatment option. Several modulators of free radical scavenger pathways have been developed and some have progressed to clinical trials. One such agent, edaravone, was approved in 2001 in Japan for the treatment of cerebral infarction. It has since been shown that edaravone can diffuse into many organs and, in addition to its effects on hydroxyl radical removal, edaravone modulates inflammatory processes, matrix metalloproteinase levels, nitric oxide production, apoptotic cell death, and necrotic cell death. Edaravone also exerts protective effects in a number of animal models of disease and tissue damage, including models of myocardial, lung, intestinal, liver, pancreatic and renal injury. Together with the proven safety of edaravone following 9 years of use as a modulator of free radical scavenging pathways in neurological disease, these additional effects of edaravone suggest that it may offer a novel treatment for several non-neurological diseases and clinical conditions in humans.

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  • KIKUCHI KIYOSHI, KAWAHARA KO-ICHI, UCHIKADO HISAAKI, MIYAGI NAOHISA, KURAMOTO TERUKAZU, MIYAGI TOMOYA, MORIMOTO YOKO, ITO TAKASHI, TANCHAROEN SALUNYA, MIURA NAOKI, MIYATA KEI, KIKUCHI CHIEMI, SAKAMOTO ROKUDAI, SHIOMI NAOTO, HASHIGUCHI TERUTO, MARUYAMA IKURO, TOKUTOMI TAKASHI, SHIGEMORI MINORU .  Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced apoptosis in ischemic neuronal injury in PC12 cells .  Neurotraumatology33 ( 2 ) 241 - 243   2010.12Reviewed International journal

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    DOI: 10.32187/neurotraumatology.33.2_241

  • Kikuchi K, Kawahara KI, Miyagi N, Uchikado H, Kuramoto T, Morimoto Y, Tancharoen S, Miura N, Takenouchi K, Oyama Y, Shrestha B, Matsuda F, Yoshida Y, Arimura S, Mera K, Tada KI, Yoshinaga N, Maenosono R, Ohno Y, Hashiguchi T, Maruyama I, Shigemori M. .  Edaravone: A new therapeutic approach for the treatment of acute stroke. .  Med Hypotheses.75 ( 6 ) 583 - 585   2010.12Edaravone: A new therapeutic approach for the treatment of acute stroke.Reviewed

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  • Miyoshi N, Horiuchi M, Inokuchi Y, Miyamoto Y, Miura N, Tokunaga S, Fujiki M, Izumi Y, Miyajima H, Nagata R, Misumi K, Takeuchi T, Tanimoto A, Yasuda N, Yoshida H and Kawaguchi H. .  Novel Microminipig Model of Atherosclerosis by High Fat and High Cholesterol Diet, Established in Japan. .  In Vivo24 ( 5 ) 671 - 680   2010.9Novel Microminipig Model of Atherosclerosis by High Fat and High Cholesterol Diet, Established in Japan.Reviewed

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  • Kikuchi K, Kawahara K, Tsuji C, Tajima Y, Kuramoto T, Shihara M, Koga Y, Shiomi N, Uchikado H, Morimoto Y, Miura N, Mera K, Ohno Y, Miyagi N, Hashiguchi T, Maruyama I, Hayabuchi N, Nakayama K, Shigemori M .  Post mortem contrast-enhanced computed tomography in a case of sudden death from acute pulmonary thromboembolism. .  Experimental and Therapeutic Medicine1 ( 3 ) 503 - 505   2010.5Post mortem contrast-enhanced computed tomography in a case of sudden death from acute pulmonary thromboembolism.Reviewed

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  • KikuchiK, Kawahara K, Biswas KK, Ito T, Tancharoen S, Shiomi N, Koda Y, Matsuda F, Morimoto Y, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Arimura S, Jie MX, Shrestha B, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Tajima Y, Uchikado H, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I .  MGB1: A new marker for estimation of the postmortem interval. .  Experimental and Therapeutic Medicine1 ( 1 ) 109 - 111   2010.1MGB1: A new marker for estimation of the postmortem interval.Reviewed

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  • Shrestha B*, Hashiguchi T*, Ito T*, Miura N*,(*These authors are equally contributed.) Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-I Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I. .  B cell-derived vascular endothelial growth factor a promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes. .  Journal of Immunology184 ( 9 ) 4819 - 4826   2010B cell-derived vascular endothelial growth factor a promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes.Reviewed

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  • Kikuchi, K., Kawahara, K., Biswas, K.K., Ito, T., Tancharoen, S., Shiomi, N., Koda, Y., Matsuda, F., Morimoto, Y., Oyama, Y., Takenouchi, K., Miura, N., Arimura, N., Nawa, Y., Arimura, S., Jie, M.X., Shrestha, B., Iwata, M., Mera, K., Sameshima, H., Ohno, Y., Maenosono, R., Tajima, Y., Uchikado, H., Kuramoto, T., Nakayama, K., Shigemori, M., Yoshida, Y., Hashiguchi, T., Maruyama, I. .  HMGB1: A new marker for estimation of the postmortem interval .  Experimental and Therapeutic Medicine1 ( 1 ) 109 - 111   2010Reviewed International journal

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    Estimation of the postmortem interval (PMI) is one of the most important tasks in forensic medicine Numerous methods have been proposed for the determination of the time since death by chemical means High mobility group box-1 (HMGB1), a nonhistone DNA-binding protein is released by eukaryotic cells upon necrosis Postmortem serum levels of HMGB1 of 90 male Wistar rats stored at 4 14 and 24 degrees C since death were measured by enzyme-linked immunosorbent assay The serum HMGB1 level showed a time-dependent increase up to seven days at 4 degrees C At 14 degrees C, the HMGB1 level peaked at day 3, decreased at day 4, and then plateaued At 24 degrees C, the HMGB1 level peaked at day 2, decreased at day 3, and then plateaued Our findings suggest that HMGB1 is related to the PMI in rats

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  • Kawaguchi Hiroaki, Miyoshi Noriaki, Fujiki Makoto, Miura Naoki, Horiuchi Masahisa, Itoh Katzuhiko, Kaneko Naoki, Miyajima Hiroaki, Nagata Ryoichi, Misumi Kazuhiro, Yasuda Nobuhiro .  Microminipig atherosclerosis model by high fat and cholesterol-diet .  JOURNAL OF PHARMACOLOGICAL SCIENCES112   34P   2010Microminipig atherosclerosis model by high fat and cholesterol-dietReviewed International journal

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  • Kikuchi K, Kawahara K, Biswas KK, Ito T, Tancharoen S, Morimoto Y, Matsuda F, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Yoshida Y, Tajima Y, Uchikado H, Kuramoto T, Nakayama K, Shigemori M, Hashiguchi T, Maruyama I. .  Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells. .  Biochem Biophys Res Commun385 ( 2 ) 132 - 136   2009.7Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells. Reviewed

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  • Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y, Nawa Y, Arimura N, Iwata M, Tajima Y, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I. .  The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. .  J Pharmacol Exp Ther326 ( 3 ) 865 - 874   2009.6The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.Reviewed

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  • 大川洋明(翻訳)、三浦直樹(監訳) .  猫の糖尿病 1. 診断,治療,モニタリング. .  J VET、インターズー22 ( 6 ) 19 - 31   2009.6猫の糖尿病 1. 診断,治療,モニタリング.

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  • 大川洋明(翻訳)、三浦直樹(監訳) .  猫の糖尿病 2. 病態生理,リスクファクター. .  J VET、インターズー22 ( 6 ) 32 - 39   2009.6猫の糖尿病 2. 病態生理,リスクファクター.

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  • Kawahara K, Hashiguchi T, Masuda K, Saniabadi AR, Kikuchi K, Tancharoen S, Ito T, Miura N, Morimoto Y, Biswas KK, Nawa Y, Meng X, Oyama Y, Takenouchi K, Shrestha B, Sameshima H, Shimizu T, Adachi T, Adachi M, Maruyama I. .  Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc. .  Int J Mol Med23 ( 5 ) 615 - 620   2009.5Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc. Reviewed

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  • Meng X, Kawahara K, Nawa Y, Miura N, Shrestha B, Tancharoen S, Sameshima H, Hashiguchi T, Maruyama I. .  1,5-Anhydro-D-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-kappaB p65 phosphorylation. .  Biochem Biophys Res Commun380 ( 2 ) 343 - 348   2009.31,5-Anhydro-D-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-kappaB p65 phosphorylation.Reviewed

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  • Kikuchi K, Tancharoen S, Matsuda F, Biswas KK, Ito T, Morimoto Y, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Tajima Y, Uchikado H, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I, Kawahara KI. .  Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4. .  Biochem Biophys Res Commun390 ( 4 ) 1121 - 1125   2009Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4.Reviewed

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  • Kawahara K, Hashiguchi T, Kikuchi K, Tancharoen S, Miura N, Ito T, Oyama Y, Nawa Y, Biswas KK, Meng X, Morimoto Y, Shrestha B, Sameshima H, Maruyama I. .  Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells. .  International journal of molecular medicine22 ( 5 ) 639 - 644   2008.11Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells.Reviewed

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  • Kawahara, K.-i., Biswas, K.K., Unoshima, M., Ito, T., Kikuchi, K., Morimoto, Y., Iwata, M., Tancharoen, S., Oyama, Y., Takenouchi, K., Nawa, Y., Arimura, N., Jie, M.X., Shrestha, B., Miura, N., Shimizu, T., Mera, K., Arimura, S.-i., Taniguchi, N., Iwasaka, H., Takao, S., Hashiguchi, T., Maruyama, I. .  C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells .  Cardiovascular Pathology17 ( 3 ) 129 - 138   2008Reviewed International journal

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    Background: C-reactive protein (CRP) is widely used as a sensitive biomarker for inflammation. Increasing evidence suggests that CRP plays a role in inflammation. High-mobility group box-1 (HMGB1), a primarily nuclear protein, is passively released into the extracellular milieu by necrotic or damaged cells and is actively secreted by monocytes/macrophages. Extracellular HMGB1 as a potent inflammatory mediator has stimulated immense curiosity in the field of inflammation research. However, the molecular dialogue implicated between CRP and HMGB1 in delayed inflammatory processes remains to be explored. Methods and results: The levels of HMGB1 in culture supernatants were determined by Western blot analysis and enzyme-linked immunosorbent assay in macrophage RAW264.7 cells. Purified CRP induced the release of HMGB1 in a dose- and time-dependent fashion. Immunofluorescence analysis revealed nuclear translocation of HMGB1 in response to CRP. The binding of CRP to the Fc gamma receptor in RAW264.7 cells was confirmed by fluorescence-activated cell sorter analysis. Pretreatment of cells with IgG-Fc fragment, but not IgG-Fab fragment, efficiently blocked this binding. CRP triggered the activation of p38MAPK and ERK1/2, but not Jun N-terminal kinase. Moreover, both p38MAPK inhibitor SB203580 and small interfering RNA significantly suppressed the release of HMGB1, but not the MEK1/2 inhibitor U-0126. Conclusion: We demonstrated for the first time that CRP, a prominent risk marker for inflammation including atherosclerosis, could induce the active release of HMGB1 by RAW264.7 cells through Fc gamma receptor/p38MAPK signaling pathways, thus implying that CRP plays a crucial role in the induction, amplification, and prolongation of inflammatory processes, including atherosclerotic lesions. (C) 2008 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.carpath.2007.08.006

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  • Kawahara K, Biswas KK, Unoshima M, Ito T, Kikuchi K, Morimoto Y, Iwata M, Tancharoen S, Oyama Y, Takenouchi K, Nawa Y, Arimura N, Jie MX, Shrestha B, Miura N, Shimizu T, Mera K, Arimura S, Taniguchi N, Iwasaka H, Takao S, Hashiguchi T, Maruyama I. .  CRP induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells. .  Cardiovascular Pathology17 ( 3 ) 129 - 138   2007.5CRP induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells.Reviewed

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  • Steffey MA, Miura N, Todhunter RJ, Nykamp SG, Freeman KP, Scarpino V, Vernier-Singer MA, Erb HN, MacLeod JN, Lust G, Burton-Wurster N. .  The potential and limitations of cartilage-specific (V+C)- fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid. .  Osteoarthritis and Cartilage12 ( 10 ) 818 - 825   2004.10The potential and limitations of cartilage-specific (V+C)- fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid.Reviewed

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  • Stelley, M.A., Miura, N., Nykamp, S.G., Freeman, K.P., Scarpino, V., Vernier-Singer, M.A., Erb, H.N., Macleod, J.N., Lust, G., Burton-Wurster, N. .  The potential and limitations of cartilage-specific (V + C)<sup>-</sup> fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid .  Osteoarthritis and Cartilage12 ( 10 ) 818 - 825   2004Reviewed International journal

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    Objective: To determine if levels of the cartilage-specific (V + C)(-) fibronectin isoform in the synovial fluid is associated with cartilage change during osteoarthritis.
    Design: Synovial fluid was collected from 26 healthy dogs presenting to the Orthopedic Surgery Clinic with unilateral cranial cruciate rupture, 22 control dogs, and 13 dogs from a colony maintained for the study of canine hip dysplasia. Total fibronectin, (V + C)(-) fibronectin, and cartilage oligomeric matrix protein (COMP) were quantitated by ELISA assays. Statistical analysis used Wilcoxon's signed-rank and rank-sum tests and Spearman's rank correlation.
    Results: The concentration of total fibronectin was increased in affected (P &lt; 0.0001) and contralateral (P = 0.0005) knees of the clinic population (compared to unaffected knees in colony controls). Both (V + C)(-) fibronectin and COMP concentrations were elevated in the contralateral knees in clinical patients relative to unaffected knees in the colony controls (P = 0.03 and P = 0.04, respectively), and relative to the affected knees (P = 0.003); however, corrections for joint effusions suggest elevated totals in the affected knees. (V + C)(-) fibronectin and COMP concentrations were correlated (r(sp) = 0.74; P &lt; 0.0001) in 30 unaffected knees of patients and colony controls. Total fibronectin was correlated negatively with months since the initial injury (r(sp) = -0.44; P = 0.03) in the affected joints. The intraoperative lesion severity score did not correlate with total fibronectin or (V + C)(-) fibronectin (P greater than or equal to 0.35).
    Conclusions: Concentration of total fibronectin in synovial fluid might be a useful biomarker for cross-sectional studies in osteoarthritis, but only (V + C)(-) fibronectin provides information specifically about cartilage damage. Elevated concentrations of (V + C)(-) fibronectin and COMP seen in the contralateral knees of patients with cranial cruciate rupture might indicate cartilage changes early in the disease process (pre-clinical). However, the wide range of values obtained limits the diagnostic value for any one individual. Joint effusions obscure the total amount of biomarkers in affected synovial joints. (C) 2004 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.joca.2004.07.002

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  • Miura, N., Fujiki, M., Misumi, K., Setoyama, K., Takegawa, K., Takahashi, T., Miyahara, K., Sakamoto, H. .  Successful use of an acceleration rate response pacemaker with a transvenous steroid-eluting screw-in lead for third-degree atrioventricular block in a labrador retriever .  Journal of Veterinary Medical Science65 ( 10 ) 1101 - 1105   2003.10Reviewed International journal

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    Permanent pacemakers are commonly used in veterinary practice and can have a dramatic effect on the treatment of heart block. A Labrador Retriever dog suffering from exercise intolerance secondary to third degree atrioventricular block was treated with a new pacemaker system. A steroid-eluting screw-in type lead that has the advantage of being more fixed to the myocardial wall without increasing the pacing threshold was used. The heart rate was regulated with an acceleration sensing pacemaker generator that included several automatic modulation systems. Nineteen months after implantation, the dog has a normal level of activity. The present case suggests that this pacemaker design may offer important advantages for canine patients.

    DOI: 10.1292/jvms.65.1101

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  • Miura N, Fujiki M, Misumi K, Setoyama K, Takegawa K, Takahashi T, Miyahara K, Sakamoto H. .  Successful use of an acceleration rate response pacemaker with a transvenous steroid-eluting screw-in lead for third-degree atrioventricular block in a labrador retriever. .  J Vet Med Sci65 ( 10 ) 1101 - 1105   2003.10Successful use of an acceleration rate response pacemaker with a transvenous steroid-eluting screw-in lead for third-degree atrioventricular block in a labrador retriever.Reviewed

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  • 三浦 直樹, 藤木 誠, 三角 一浩, 瀬戸山 健太郎, 竹川 和明, 高橋 健, 宮原 健吉, 坂本 紘 .  第三度の房室ブロックのラブラドールレトリバーに対するAcceleration Rate Response制御型ペースメーカと経静脈Steroid-eluting Screw-in型リードを用いた治検例(短報)(Successful Use of an Acceleration Rate Response Pacemaker with a Transvenous Steroid-Eluting Screw-in Lead for Third-Degree Atrioventricular Block in a Labrador Retriever) .  The Journal of Veterinary Medical Science65 ( 10 ) 1101 - 1105   2003.10第三度の房室ブロックのラブラドールレトリバーに対するAcceleration Rate Response制御型ペースメーカと経静脈Steroid-eluting Screw-in型リードを用いた治検例(短報)(Successful Use of an Acceleration Rate Response Pacemaker with a Transvenous Steroid-Eluting Screw-in Lead for Third-Degree Atrioventricular Block in a Labrador Retriever)Reviewed International journal

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  • Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R, Fujii R, Miura N, Komiya S, Nishioka K, Maruyama I, Fukamizu A, Nakajima T. .  Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. .  Genes Dev17 ( 19 ) 2436 - 2449   2003.7Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy.Reviewed

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  • Kamimura R, Miura N, Suzuki S. .  The hemodynamic effects of acute myocardial ischemia and reperfusion in Clawn miniature pigs. .  Exp Anim52 ( 4 ) 335 - 338   2003.7The hemodynamic effects of acute myocardial ischemia and reperfusion in Clawn miniature pigs.Reviewed

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  • 上村 亮三, 三浦 直樹, 鈴木 秀作 .  Clawnミニブタを用いた急性心筋虚血及び再灌流時の血行動態(The Hemodynamic Effects of Acute Myocardial Ischemia and Reperfusion in Clawn Miniature Pigs) .  Experimental Animals52 ( 4 ) 335 - 338   2003.6Clawnミニブタを用いた急性心筋虚血及び再灌流時の血行動態(The Hemodynamic Effects of Acute Myocardial Ischemia and Reperfusion in Clawn Miniature Pigs)Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:(公社)日本実験動物学会  

    Clawnミニブタに心筋虚血を作製した.連続虚血群の3/8例が虚血後20分以内に,虚血再灌流群の4/9例が再灌流後に不整脈で死亡した.虚血領域は再灌流群の方が狭かった.再灌流障害は血行動態に重大な影響を与えることが示唆された

  • Miura N, Fujiki M, Miyoshi Y, Misumi K, Sakamoto H. .  Steroid injection therapy in a feline solitary bone cyst. .  J. Vet. Med. Sci65 ( 4 ) 523 - 525   2003.4Steroid injection therapy in a feline solitary bone cyst.Reviewed

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  • 三浦 直樹, 藤木 誠, 三好 宣彰, 三角 一浩, 坂本 紘 .  ステロイド局所注入療法を行った猫の単発性骨嚢胞(Solitary Bone Cyst)の一例(Steroid Injection Therapy in a Feline Solitary Bone Cyst) .  The Journal of Veterinary Medical Science65 ( 4 ) 523 - 525   2003.4ステロイド局所注入療法を行った猫の単発性骨嚢胞(Solitary Bone Cyst)の一例(Steroid Injection Therapy in a Feline Solitary Bone Cyst)Reviewed International journal

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  • Setoyama K, Ota H, Miura N, Fujiki M, Misumi K, Sakamoto H. .  Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dog. .  J. Vet. Med. Sci.64 ( 6 ) 499 - 503   2002.6Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dog. Reviewed

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  • 瀬戸山 健太郎, 大田 宏美, 三浦 直樹, 藤木 誠, 三角 一浩, 坂本 紘 .  低酸素下の犬におけるミルリノンの血行動態ならびに臓器血流に及ぼす影響(Effects of Milrinone on Hemodynamics and Regional Blood Flow in the Hypoxic Dog) .  The Journal of Veterinary Medical Science64 ( 6 ) 499 - 503   2002.6低酸素下の犬におけるミルリノンの血行動態ならびに臓器血流に及ぼす影響(Effects of Milrinone on Hemodynamics and Regional Blood Flow in the Hypoxic Dog)Reviewed International journal

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  • Kawabata H, Kawahara K, Kanekura T, Araya N, Daitoku H, Hatta M, Miura N, Fukamizu A, Kanzaki T, Maruyama I, Nakajima T. .  Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiation. .  J. Biol. Chem.277 ( 10 ) 8099 - 8105   2002.3Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiation.Reviewed

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  • MISUMI Kazuhiro, TORII Tetsutaroh, AOKI Osamu, FUJIKI Makoto, MIURA Naoki, YANAGITA Kohichi, SAKAMOTO Hiroshi .  Effects of Trimming on Hoof Growth, Hoof-disease Occurrence, and Productivity in Japanese Black Beef Cattle .  Journal of the Japan Veterinary Medical Association54 ( 11 ) 829 - 836   2001.11Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Veterinary Medical Association  

    This study was designed to determine effects of trimming on hoof growth, hoof-disease occurrence, and beef productivity. Sixteen Japanese black steers (13.0&plusmn;2.0 months of age, 308.0&plusmn;30.8 kg in body weight) were divided into 4 groups: the no-trimming group and group 2; in which trimming was performed at 3-month intervals; group 3, in which trimming was performed at 6-month intervals; and group 4, in which trimming was performed at 12month-intervals. At 19-month intervals, hooves were measured and hoof appearance recorded.After slaughter, we made pathological investigations of hoof and joint diseases and obtained scores representing the quantity and quality of beef products. When trimming intervals were longer, hoof angle was smaller, and hoof wall and bulb height increased. The occurrence of hoof diseases in the no-trimming group was significantly higher (P<0.05) than in the other groups. Scores for beef-product quantity were significantly higher (P<0.05) in group 3, in which trimming was performed at 6-month intervals, than in the other groups. These results suggest that trimming may be useful in maintaining normal hoof growth and preventing deformation and disease.

    DOI: 10.12935/jvma1951.54.829

    CiNii Books

  • MISUMI Kazuhiro, SHINSATO Takeshi, AOKI Osamu, SETOYAMA kentaroh, MIURA Naoki, YANAGITA Kohichi, SAKAMOTO Hiroshi .  Effects of Hoof Trimming on Hematological and Biochemical Variables during Transport-induced Stress in Japanese Black Cattle .  Journal of the Japan Veterinary Medical Association54 ( 11 ) 837 - 840   2001.11Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Veterinary Medical Association  

    The purpose of this study is to determine effects of hoof trimming on transport-induced stress in beef cattle. Forty-one Japanese black steers were randomly divided into 2 groups: trimmed group (n=27) and untrimmed group (n=14). In the trimmed group, hoof trimming was repeated every 6 months, with the final trimming performed 3 months before shipment. The untrimmed group was not trimmed at all until shipment time. Before and after truck transportation to the shipping destination (57.8 km, 4 hours), the cattle were weighed, and their blood was sampled for hematological and biochemical analysis. The indices of transport-induced stress were creatine phosphokinase (CK) and cortisol. In both groups, CK and cortisolincreased after transportation. Increase in the parameters was lower in the trimmed group than in the untrimmed group. Lower CK activity in the trimmed group suggests that the physical demand for posture support during transport in the vehicle was more restricted in thetrimmed group. Plasma cortisol increased less in the trimmed group than in the untrimmed group. This could mean that periodical trimming effectively inhibits transport-induced stress in beef cattle.

    DOI: 10.12935/jvma1951.54.837

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  • 三角 一浩, 鳥居 哲太郎, 青木 修, 藤木 誠, 三浦 直樹, 柳田 宏一, 坂本 紘 .  削蹄による肥育用黒毛和種牛の蹄形,蹄病発生及び生産性の変化 .  日本獣医師会雑誌54 ( 11 ) 829 - 836   2001.11削蹄による肥育用黒毛和種牛の蹄形,蹄病発生及び生産性の変化Reviewed International journal

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  • 三角 一浩, 新里 健, 青木 修, 瀬戸山 健太郎, 三浦 直樹, 柳田 宏一, 坂本 紘 .  肉用牛の輸送ストレスに対する削蹄の効果 .  日本獣医師会雑誌54 ( 11 ) 837 - 840   2001.11肉用牛の輸送ストレスに対する削蹄の効果Reviewed International journal

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  • FUJIKI Makoto, MIURA Naoki, MISUMI Kazuhiro, TSURUTA Tsutomu, SAKAMOTO Hiroshi .  A Case of Canine Cricopharyngeal Achalasia .  Journal of the Japan Veterinary Medical Association54 ( 9 ) 697 - 700   2001.9Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Veterinary Medical Association  

    A three-year-old, female Shih Tzu with a history of dysphagia persisting since weaning had been kept on a liquid diet for about two years. The dog was referred to us because of difficulty in swallowing liquid food. Clinical signs, radiographic findings, and fluoroscopic examination after ingestion of food mixed with barium confirmed a diagnosis of cricopharyngeal achalasia. Four days later, we performed cricopharyngeal myotomy. After surgery, the dog no longer had difficulty swallowing food and was discharged on the third postoperative day. The dog has been clinically normal for 17 months.

    DOI: 10.12935/jvma1951.54.697

    CiNii Books

  • 藤木 誠, 三浦 直樹, 三角 一浩, 鶴田 勉, 坂本 紘 .  犬の輪状咽頭筋アカラジアの1例 .  日本獣医師会雑誌54 ( 9 ) 697 - 700   2001.9犬の輪状咽頭筋アカラジアの1例Reviewed International journal

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  • MIURA Naoki, SUZUKI Syusaku, HAMADA Yuji, KAMIMURA Ryozo, UMEMOTO Chiyoshi, FUJIKI Makoto, MISUMI Kazuhiro, SAKAMOTO Hirosi .  Effects of Exposure to Alternating-current, High-voltage, Electric Potential on Experimental Hypertension in Dahl-S Rats .  Journal of the Japan Veterinary Medical Association54 ( 6 ) 472 - 475   2001.6Reviewed International journal

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japan Veterinary Medical Association  

    Antihypertensive effect of exposure alternating current, high-voltage, electrical potential (AC-HVEP) were investigated in Dahl salt-sensitive (Dahl-S) rats used as models of salt-induced hypertension. The animals were divided into two groups: rats exposure to AC-HVEP (AC-HVEP group) and a control group not exposed to AC-HVEP. Throughout the experimental period, water with an addition of 1.0% NaC1 was given the animals. Progressive hypertension in the AC-HVEP group was significantly less serious than in the control group. In addition, histopathological examination showed greater restriction of lesions in the AC-HVEP than in the control group. Our results suggest that AC-HVEP exposure can suppress progressive hypertension secondary to chronic renal failure.

    DOI: 10.12935/jvma1951.54.472

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  • 三浦直樹、鈴木秀作、浜田佑二、上村亮三、梅本千代志、藤木誠、三角一浩、坂本紘 .  交流高圧電位負荷の高血圧モデル動物に対する高血圧抑制効果. .  日獣会誌54 ( 6 ) 472 - 475   2001.6 交流高圧電位負荷の高血圧モデル動物に対する高血圧抑制効果.Reviewed

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  • 上村 亮三, 鈴木 秀作, 三浦 直樹, 宮原 健吉 .  コレステロール投与New Zealand Whiteウサギの肺動脈硬化症と肺動脈圧(Pulmonary Atherosclerosis and Pulmonary Arterial Pressure in Cholesterol-Fed New Zealand White Rabbits) .  The Journal of Veterinary Medical Science63 ( 6 ) 647 - 653   2001.6コレステロール投与New Zealand Whiteウサギの肺動脈硬化症と肺動脈圧(Pulmonary Atherosclerosis and Pulmonary Arterial Pressure in Cholesterol-Fed New Zealand White Rabbits)Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:(公社)日本獣医学会  

    実験を3群に分け,コントロール群にはウサギ用標準飼料を8週間,コレステロール投与群には標準飼料に0.5%コレステロール及び0.25%胆汁酸を添加した高コレステロール飼料を8週間(実験群1)と15週間(実験群2),1日90g/例ずつ投与した.肺動脈圧は,収縮期,拡張期共に,実験群2が最も高く,次に実験群1,コントロール群の順であった.3群間に大きな差は認められなかったが,平均肺動脈圧のコントロール群と実験群2の間に統計学的有意差が認められた.組織学的には実験群1の肺動脈は幹気管支〜細気管支レベルの肺動脈を中心に,血管内皮下に軽度の限局性の泡沫細胞集簇が認められた.実験群2では細気管支レベルの肺動脈を中心に泡沫細胞の集簇により,中等度〜高度の血管内腔狭窄像が観察され,増殖細胞の一部は中膜から外膜に達していた.しかしながら,肺全体では高度病変は部分的には認められるものの,軽度病変が主体であった.今回の結果からコレステロール投与ウサギの肺動脈にも泡沫細胞増殖を主体とする動脈硬化病変が観察され,内膜肥厚及び血管内腔の高度狭窄も認められた.一方,肺高血圧を呈する程ではなかったものの,肺動脈圧は経時的に漸増した

  • K Misumi, O Tateno, M Fujiki, N Miura, H Sakamoto .  The risk of contrast media-induced ventricular fibrillation is low in canine coronary arteriography with ioxilan .  JOURNAL OF VETERINARY MEDICAL SCIENCE62 ( 4 ) 421 - 426   2000.4Reviewed International journal

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    Previous studies have proposed that sodium supplement to nonionic contrast media (CM) can decrease the risk of ventricular fibrillation (VF). This study was designed to compare the occurence of VF induced by ioxilan (containing 9 mmol/LNa+) with other nonionic CMs. After wedging a catheter in the right coronary artery, test solutions including ioxilan, ioversol, iomeprol, and iopromide were infused for 30 sec at the rate of 0.4 ml/sec or until VF occurred. Then, incidence of VF, contact time (i.e. the time required to produce VF), and QTc were measured. Also, the CMs other than ioxilan were investigated at sodium levels adjusted to 9 and 20 mmol/L Na+. The incidence of VF with ioxilan (0%) was the lowest of all. In the other CMs, the incidence decreased in accordance with increase of sodium. Iomeprol and iopromide showed significant reduction of VF incidence at the sodium level of 20 mmol/L. The higher sodium supplements also prolonged the contact times. The increase of QTc was the greatest in ioxilan. Ioxilan has the least arrythmogenic property among the current low-osmolality nonionic CMs. This property might be attributable to an optimal sodium concentration of 9 mmol/L in the CM.

    DOI: 10.1292/jvms.62.421

    Web of Science

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  • HIRAKAWA Atsushi, FUJIKI Makoto, MIURA Naoki, SHIBAYAMA Hinako, TAKAHASHI Yoshiaki, OMICHI Yoshihiro, NOGUCHI Kayo, YAMAMOTO Masaaki, SAKAMOTO Hiroshi .  Pacemaker Implantation in a Cat with Paroxysmal Third-degree Atrioventricular Block .  Journal of the Japan Veterinary Medical Association53 ( 2 ) 75 - 79   2000.2Reviewed International journal

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  • 平川 篤, 藤木 誠, 三浦 直樹, 柴山 比奈子, 高橋 義明, 大道 嘉広, 野口 佳代, 山本 昌章, 坂本 紘 .  発作性第3度房室ブロックに対しペースメーカーの植え込みを実施した猫の1例 .  日本獣医師会雑誌53 ( 2 ) 75 - 79   2000.2発作性第3度房室ブロックに対しペースメーカーの植え込みを実施した猫の1例Reviewed International journal

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  • HIRAKAWA Atsushi, FUJIKI Makoto, MIURA Naoki, SHIBAYAMA Hinako, TAKAHASHI Yoshiaki, OMICHI Yoshihiro, NOGUCHI Kayo, YAMAMOTO Masaaki, SAKAMOTO Hiroshi .  Pacemaker Implantation in a Cat with Paroxysmal Third-degree Atrioventricular Block .  Journal of the Japan Veterinary Medical Association53 ( 2 ) 75 - 79   2000Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Veterinary Medical Association  

    A male mongrel cat (age 8 years and 5 months) was referred to our clinic because of syncopal episodes. Electrocardiography revealed paroxysmal third-degree atrioventricular block. Because syncopal episodes became increasingly frequent over a period of 5 months, permanent pacemaker implantion was performed. One year after the operation, no further syncopes had occurred. To the best of our knowledge, this is the first report in Japan of long-term observation of pacemaker implantation in a cat.

    DOI: 10.12935/jvma1951.53.75

    CiNii Books

  • Kakura, H., Miyahara, K., Amitani, S., Sohara, H., Koga, M., Sakamoto, H., Misumi, K., Miura, N. .  Hemodynamic effects of intravenous administration of olprinone hydrochloride on experimental pulmonary hypertension .  Arzneimittel-Forschung/Drug Research50 ( 6 ) 515 - 519   2000Reviewed International journal

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    To examine acute effects of olprinone hydrochloride (CAS 1067302-54-0, Coretec®) on pulmonary hypertension, hypoxic pulmonary hypertension was produced in 6 adult Beagle dogs. Using this pulmonary hypertension model, single intravenous bolus injections of olprinone at doses of 10, 30 and 100 μg/kg were administered at 5-min intervals and hemodynamic parameters were evaluated. Heart rate increased at doses of 30 and 100 μg/kg, but did not change at a dose of 10 μg/kg. Mean aortic pressure, mean pulmonary arterial pressure, pulmonary vascular resistance and systemic vascular resistance and right ventricular stroke work index did not change at doses of 10 and 30 μg/kg, but they decreased significantly at a dose of 100 μg/kg. On the other hand, cardiac index and the first derivative value of the left ventricular pressure did not show significant change at all doses. These results indicate the vasodilating effects on peripheral and pulmonary vessels in hypoxic model at high doses of olprinone. Its application in right heart failure accompanied by pulmonary hypertension therefore is expected to yield promising results.

    DOI: 10.1055/s-0031-1300240

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  • Misumi, K., Fujiki, M., Miura, N., Sakamoto, H. .  Uterine horn torsion in two non-gravid bitches .  Journal of Small Animal Practice41 ( 10 ) 468 - 471   2000Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BRITISH VETERINARY ASSOC  

    Uterine torsion secondary to sacculation of the uterine horns was diagnosed in two non-gravid bitches which were presented with anorexia, polydipsia and an acutely swollen abdomen, On the basis of the radiological and ultrasonographic findings, which indicated the presence of an enlarged spherical or tubular structure filled with hypoechoic material in the caudal abdomen, a tentative diagnosis of pyometra was made. Exploratory laparotomy revealed unilateral uterine horn torsion along the longitudinal axis, with bilateral fluid-filled sacculations. Ovariohysterectomy was performed in both cases. Pathological examination of the uteri demonstrated haematometra in one dog and pyometra in the other.

    DOI: 10.1111/j.1748-5827.2000.tb03144.x

    Web of Science

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  • Miura N, Suzuki S, Hamada Y, Kamimura R, Fujiki M, Misumi K, Sakamoto H. .  Salt water promotes hypertension in Dahl-S rats. .  Exp. Anim48 ( 4 ) 289 - 292   1999.10Salt water promotes hypertension in Dahl-S rats.Reviewed

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  • 三浦 直樹, 鈴木 秀作, 浜田 佑二, 上村 亮三, 藤木 誠, 三角 一浩, 坂本 紘 .  食塩水投与によるDahl-S-Ratの高血圧症の作成 .  Experimental Animals48 ( 4 ) 289 - 292   1999.10食塩水投与によるDahl-S-Ratの高血圧症の作成Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:(公社)日本実験動物学会  

  • Kamimura, R., Suzuki, S., Sakamoto, H., Miura, N., Misumi, K., Miyahara, K. .  Development of atherosclerotic lesions in cholesterol-loaded rabbits .  Experimental Animals48 ( 1 ) 1 - 7   1999.1Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:INT PRESS EDITING CENTRE INC  

    To examine both of the target vessels and the optimal time of their endothelial denudation to study vascular restenosis after balloon injury in cholesterol-loaded rabbits, we made 36 atherosclerotic rabbits by feeding a hypercholesterol diet, and histologically examined the onset time and the development of atherosclerosis. Atheromatous changes were observed first after the 5th week in the thoracic aorta from the start of the diet, and then extended to the abdominal aorta, coronary artery with time. The atherosclerotic lesions in the thoracic aorta and the proximal portion of the coronary artery showed high-grade concentric intimal thickening with luminal stenosis. The abdominal aortic lesion mildly progressed. In the renal, carotid and femoral arteries, in contrast, slight atheroscleromatous changes developed during the diet period. These results suggest that the thoracic and abdominal aortas and the coronary artery would be suitable as target vessels to study vascular restenosis after balloon injury, and the endothelial denudation of these vessels should be performed between the 8th and 15th week in this diet protocol for an accurate analysis.

    DOI: 10.1538/expanim.48.1

    Web of Science

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  • 上村 亮三, 鈴木 秀作, 坂本 紘, 三浦 直樹, 三角 一浩, 宮原 健吉 .  コレステロール負荷ウサギにおける動脈硬化病変の進展 .  Experimental Animals48 ( 1 ) 1 - 7   1999.1コレステロール負荷ウサギにおける動脈硬化病変の進展Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:(公社)日本実験動物学会  

    36例のNZWウサギに0.5%コレステロール含有飼料を4〜15週間投与し,病変形成時期と進展経過について組織学的に検索した.病変形成時期は胸大動脈が投与5週目,腹大動脈が6週目,冠動脈が7週目,腎・総頸・大腿動脈が8週目と部位によって大きな差が認められた.胸大動脈・冠動脈の病変は経時的に進展し,中等度〜高度の内腔狭窄も認められたが,腹大動脈病変の進展経過は比較的緩やかであった.腎・総頸・大腿動脈の病変進展は極めて緩徐で,15週目でも局所病変にとどまった.この実験結果から,動脈硬化病変を有する血管を用いたballoon傷害後のrestenosisに関する研究では,cholesterol投与15週迄のモデルでも,胸大動脈・冠動脈・腹大動脈が対象血管となり得,それらの内皮剥離の至適時期は投与後8〜15週の間であることが推察された

  • Amitani, S., Miyahara, K., Sohara, H., Kakura, H., Koga, M., Moriyama, Y., Taira, A., Nagano, S.-I., Miura, N., Misumi, K., Sakamoto, H. .  Experimental His-bundle pacing: Histopathological and electrophysiological examination .  PACE - Pacing and Clinical Electrophysiology22 ( 4 I ) 562 - 566   1999Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    His-bundle pacing gives a more physiological ventricular contraction in comparison to right ventricular apical pacing. However the problems of lead fixation and stability of long-term His-bundle pacing are yet unsolved. We used six adult beagles, in which a screw-in lead was anchored in the His- bundle region for observation of the pacing conditions and histopathologic changes of the conduction system over the course of 2 months. In the results, a satisfactory fixation was obtained using a conventional screw-in lead and no histological influence on the conduction system was observed. The pacing threshold at the time of implantation was 1.15 ± 0.69V (3.23 ± 3.08 mA) in the pulse width of 0.5 ms. R wave amplitude, the impedance and slew rate were 7.28 ± 2.04 mV, 409 ± 102 Ohm, and 0.65 ± 0.41 V/s, respectively. Two months later, these parameters changed to 2.83 ± 1.06 V (10.4 ± 5.71 mA), 5.63 ± 1.62 mV, 310 ± 71.3 Ohm, and 0.49 ± 0.22 V/s, respectively. These results suggest the feasibility of clinical application of permanent His- bundle pacing.

    DOI: 10.1111/j.1540-8159.1999.tb00497.x

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  • 藤木 誠, 三浦 直樹, 三角 一浩, 坂本 絋 .  麻酔モニター(BP-508)の終末呼気二酸化炭素分圧と平均動脈圧に対するイヌでの有効性 .  獣医麻酔外科学雑誌 = Japanese journal of veterinary anesthesia & surgery29   55   1998.10Reviewed International journal

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  • KAMIMURA Shunichi, HASHINOKUCHI Tetsu, USHINOHAMA Kanji, MIURA Naoki, HAMANA Katsumi, SAKAMOTO Hiroshi .  A Clinical Case of Bladder Rupture Occurring in a New-Born Japanese Black Calf .  Journal of the Japan Veterinary Medical Association51 ( 5 ) 246 - 248   1998.5Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Veterinary Medical Association  

    A 15-day-old female calf complaining urinary obstruction and hematuria, was diagnosed as bladder rupture by positive-contrast cystography and ultrasonography. Through a posterior ventral midline incision one third of bladder containing ruptured devitalized tissue was debrided, resulting in recovery after operation. The case was suspected to be due to urachal anomaly type 2, a vesicourachal diverticulum.

    DOI: 10.12935/jvma1951.51.246

  • Sakamoto, H., Kirihara, H., Fujiki, M., Miura, N., Misumi, K. .  The Effects of Medetomidine on Maternal and Fetal Cardiovascular and Pulmonary Function, Intrauterine Pressure and Uterine Blood Flow in Pregnant Goats .  Experimental Animals46 ( 1 ) 67 - 73   1997.1Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:International Press Editing Centre Incorporation  

    To investigate the effects of medetomidine on late pregnant goats, medetomidine induced changes in maternal or fetal circulation and acid-base balance, as well as changes in intrauterine pressure (IUP) and uterine blood flow (UBF), were studied. Intramuscular administration of medetomidine (40 μg/kg b.w.) decreased the heart rate (HR) and arterial blood pressure (ABP) of the mother, and the change in HR was significant statistically (p&lt
    0.05). In the fetus, HR and ABP showed a transient decrease and increase (p&lt
    0.05), respectively. A decrease in maternal arterial blood pH and oxygen partial pressure (PO2) and an increase in carbon dioxide partial pressure (PCO2) were recorded alter the injection, but none was significant. In the fetus, arterial blood PO2 decreased significantly (p&lt
    0.05) after 5 min of administration, and a significant metabolic acidemia supported by a decrease in base excess was observed. Within 1 to 4 min after the administration of medetomidine, IUP began to rise and remained high for 10 to 14 min. Thereafter, the rise in IUP was frequent and periodical. After the injection, UBF significantly (p&lt
    0.05) decreased, and the fall in UBF was associated with a rise in IUP. The maternal and fetal serum medetomidine concentration increased remarkably after the injection of medetomidine into the mother. These observations in late pregnant goats suggested that medetomidine induced a decrease in maternal cardiac output, a decrease in UBF arising from the induction of uterine contractions, and transplacental medetomidine can have a suppressive effect on the fetus.

    DOI: 10.1538/expanim.46.67

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Books

  • 犬と猫の画像診断BOOK

    桃井康行、三浦直樹( Role: Joint author)

    ファームプレス  2015.2 

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    Language:Japanese Book type:Scholarly book

  • 当施設における画像診断科の現状ならびにダイナミックCT造影検査の症例紹介.

    三浦直樹( Role: Sole author)

    CLINIC NOTE  2012.2 

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    Language:Japanese Book type:Scholarly book

  • 宿主RNAと第XII因子の関係をご説明ください.

    三浦直樹( Role: Sole author)

    血栓と循環  2011.1 

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MISC

  • 総論① 犬と猫の血栓症 リスク疾患と抗血栓療法 Invited

    三浦直樹

    SA Medicine   28 ( 5 )   4 - 13   2022.10

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  • 文献アーカイブ―獣医学/医学の視点からー No.95-97

    三浦直樹

    伴侶動物画像診断   7 ( 5 )   103 - 105   2022.10

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • 総論② DICと抗血栓療法 Invited

    三浦直樹

    SA Medicine   28 ( 5 )   14 - 21   2022.10

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  • 疾患とそれにかかわる炎症(第3回) 脳梗塞と炎症

    三浦 直樹

    Veterinary Immunology for Practitioners   7 ( 3 )   34 - 40   2022.7

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publisher:動物アレルギー検査(株)  

  • 【牛の画像診断】(Chapter 1)X線検査 デジタル画像装置の利用と、X線画像の読影ピットフォールの基本

    三浦 直樹

    臨床獣医   40 ( 7 )   29 - 35   2022.6

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publisher:(株)緑書房  

  • 文献アーカイブ―獣医学/医学の視点からー No.92-94

    三浦直樹

    伴侶動物画像診断   7 ( 3 )   103 - 105   2022.6

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  • 疾患とそれにかかわる炎症(第2回) "血管"に起こる炎症 血管炎!(後半)

    三浦 直樹

    Veterinary Immunology for Practitioners   7 ( 2 )   25 - 29   2022.4

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publisher:動物アレルギー検査(株)  

  • 文献アーカイブ―獣医学/医学の視点からー No.89-91

    三浦直樹

    伴侶動物画像診断   7 ( 1 )   93 - 95   2022.2

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  • 疾患とそれにかかわる炎症(第1回) "血管"に起こる炎症 血管炎! Invited

    三浦 直樹

    Veterinary Immunology for Practitioners   7 ( 1 )   56 - 62   2022.1

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:動物アレルギー検査(株)  

  • 文献アーカイブ―獣医学/医学の視点からー No.86-88

    三浦直樹

    伴侶動物画像診断   6 ( 5 )   99 - 101   2021.10

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  • 疾患とそれにかかわる炎症(第0回) 新シリーズを始める前の予備知識とこれまでの"炎症"への追加事項!

    三浦 直樹

    Veterinary Immunology for Practitioners   6 ( 4 )   32 - 37   2021.10

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    Language:Japanese   Publisher:動物アレルギー検査(株)  

  • 好中球による最前線防衛反応“Neutrophil extracellular traps (NETs)”と免疫血栓 Invited

    三浦直樹

    MPアグロジャーナル   45   14 - 17   2021.7

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  • 文献アーカイブ―獣医学/医学の視点からー No.83-85

    三浦直樹

    伴侶動物画像診断   6 ( 3 )   103 - 105   2021.6

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  • 炎症(第10回) 急性&慢性炎症と組織恒常性に適材適所で働く"マクロファージ"のDiversity

    三浦 直樹

    Veterinary Immunology for Practitioners   6 ( 2 )   34 - 40   2021.4

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    Language:Japanese   Publisher:動物アレルギー検査(株)  

  • 文献アーカイブ―獣医学/医学の視点からー No.80-82

    三浦直樹

    伴侶動物画像診断   6 ( 1 )   102 - 104   2021.2

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  • 炎症(第9回) 細胞内のタンパク質の機能管理機構"ユビキチン・プロテアソーム系"と炎症

    三浦 直樹

    Veterinary Immunology for Practitioners   6 ( 1 )   38 - 45   2021.1

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    Publisher:動物アレルギー検査(株)  

  • 文献アーカイブ―獣医学/医学の視点からー No.77-79

    三浦直樹

    伴侶動物画像診断   5 ( 5 )   103 - 105   2020.10

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  • 炎症(第8回) 細胞内炎症誘導の立役者"インフラマソーム(Inflammasome)"

    三浦 直樹

    Veterinary Immunology for Practitioners   5 ( 4 )   44 - 49   2020.10

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    Publisher:動物アレルギー検査(株)  

  • 文献アーカイブ―獣医学/医学の視点からー No.72-76

    三浦直樹

    伴侶動物画像診断   5 ( 3 )   102 - 104   2020.7

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  • 炎症(第7回) TLRs以外にもある"自己も非自己も認識して炎症誘導するPRRs達"

    三浦 直樹

    Veterinary Immunology for Practitioners   5 ( 3 )   48 - 53   2020.7

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  • 牛凍結精液の人工授精や受精卵移植の受胎率向上を確認ー牛生殖細胞の新たな凍結保存法を開発

    三浦直樹、窪田力

    DAIRYMAN   70 ( 5 )   76 - 79   2020.5

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  • 文献アーカイブ―獣医学/医学の視点からー No.68-72

    三浦直樹

    伴侶動物画像診断   5 ( 1 )   103 - 105   2020.2

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  • 炎症6:血管内の炎症:播種性血管内凝固症候群:”disseminated intravascular coagulation: DIC”

    三浦直樹

    Veterinary Immunology for Practitioners   5 ( 1 )   18 - 26   2020.1

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  • 炎症(第6回) 血管内の炎症 播種性血管内凝固症候群"disseminated intravascular coagulation:DIC"

    三浦 直樹

    Veterinary Immunology for Practitioners   5 ( 1 )   17 - 26   2020.1

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    Publisher:動物アレルギー検査(株)  

  • LPS誘導ウサギDICモデルにおけるDIC初期の血小板の動向:血栓形成の可視化による検索

    岩永朋子, 齋藤靖生, 畑井仁, 永里朋香, 伊藤隆史, 福島隆治, 高橋雅, 丸山征郎, 三浦直樹

    日本獣医学会学術集会講演要旨集   163rd   2020

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  • 文献アーカイブ―獣医学/医学の視点からー No.63-67

    三浦直樹

    伴侶動物画像診断   4 ( 5 )   103 - 105   2019.10

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  • 炎症(第5回) "無菌的炎症(sterile inflammation)"と"自己炎症性(autoinflammation)疾患"

    三浦 直樹

    Veterinary Immunology for Practitioners   4 ( 4 )   12 - 17   2019.10

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  • 文献アーカイブ―獣医学/医学の視点からー No.58-62

    三浦直樹

    伴侶動物画像診断   4 ( 4 )   103 - 105   2019.8

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  • 炎症4:新しい細胞間情報伝達分子”エクソソーム(Exosome)”と炎症

    三浦直樹

    Veterinary Immunology for Practitioners   15   18 - 25   2019.7

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  • 安全に確実に経口投与する新しい投薬器~より安全に、猫も人もwin winになる方法~

    三浦直樹、岩永朋子

    MPアグロジャーナル   38   18 - 21   2019.7

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  • 炎症(第4回) 新しい形の細胞間情報伝達分子"エクソソーム(Exosome)"

    三浦 直樹

    Veterinary Immunology for Practitioners   4 ( 3 )   18 - 25   2019.7

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  • 文献アーカイブ―獣医学/医学の視点からー No.52-57

    三浦直樹

    伴侶動物画像診断   4 ( 2 )   103 - 105   2019.4

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  • 炎症3:生命活動のファインチューナー”microRNA”と炎症

    三浦直樹

    Veterinary Immunology for Practitioners   14   16 - 24   2019.4

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  • 炎症(第3回) 生命活動のファインチューナー"microRNA"と炎症

    三浦 直樹

    Veterinary Immunology for Practitioners   4 ( 2 )   16 - 24   2019.4

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  • 炎症2:炎症最前線で防波堤となる好中球”Neutrophil extracellular traps(NETs)とNETosis”

    三浦直樹

    Veterinary Immunology for Practitioners   13   26 - 32   2019.1

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  • 炎症(第2回) 炎症最前線で防波堤となる好中球"Neutrophil extracellular traps(NETs)とNETosis"

    三浦 直樹

    Veterinary Immunology for Practitioners   4 ( 1 )   26 - 32   2019.1

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  • アマミノクロウサギの潜在精巣の1例

    前谷史恵, 落合晋作, 桜井普子, 伊藤圭子, 三浦直樹, 岩永朋子, 古澤悠, 大和修

    動物園水族館雑誌   60 ( 4 )   2019

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  • 原発性上皮小体機能亢進症の犬4例におけるCT検査の検討

    岩永朋子, 高橋香, 蔵元智英, 十川英, 齋藤靖生, 三浦直樹, 畑井仁, 一二三達郎, 三好宣彰, 桃井康行

    日本産業動物獣医学会(九州)・日本小動物獣医学会(九州)・日本獣医公衆衛生学会(九州)   2019   2019

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  • 文献アーカイブ―獣医学/医学の視点からー No.47-51

    三浦直樹

    伴侶動物画像診断   3 ( 6 )   103 - 105   2018.12

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  • 文献アーカイブ―獣医学/医学の視点からー No.42-46

    三浦直樹

    伴侶動物画像診断   3 ( 45 )   102 - 105   2018.10

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  • 炎症1:炎症惹起の刺激誘導分子”DAMPs”

    三浦直樹

    Veterinary Immunology for Practitioners   12   17 - 24   2018.10

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  • 新規血栓・凝固能のモニタリング装置のT-TAS

    三浦直樹、岩永朋子

    MPアグロジャーナル   35   14 - 17   2018.10

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  • 炎症(第1回) 炎症惹起の刺激誘導分子"DAMPs"

    三浦 直樹

    Veterinary Immunology for Practitioners   3 ( 4 )   17 - 24   2018.10

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  • 症例に学ぶ難治性疾患の診かた・考え方(Case 27) 子牛の肋骨骨折

    安藤 貴朗, 本川 裕介, 藤川 拓郎, 乙丸 孝之介, 三浦 直樹, 窪田 力

    臨床獣医   36 ( 10 )   8 - 11   2018.9

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  • 文献アーカイブ―獣医学/医学の視点からー No.38-41

    三浦直樹

    伴侶動物画像診断   3 ( 4 )   84 - 86   2018.8

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  • 文献アーカイブ―獣医学/医学の視点からー No.34-37

    三浦直樹

    伴侶動物画像診断   3 ( 2 )   95 - 97   2018.4

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  • Bovine radiology: technical and diagnostic basics and pitfalls. Reviewed

    Miura N

    Jpn. J. Large Anim. Clin.   8   269 - 275   2018.3

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  • 文献アーカイブ―獣医学/医学の視点からー No.29-33

    三浦直樹

    伴侶動物画像診断   3 ( 1 )   103 - 105   2018.2

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  • 【炎症・免疫疾患とmicroRNA】乳腺炎で変化する乳汁中のmicroRNA ウシの乳腺炎乳汁の炎症関連microRNAレベル Invited

    三浦 直樹, Lai Yu-Chang

    臨床免疫・アレルギー科   69 ( 1 )   53 - 59   2018.1

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  • 全血血栓形成観測システム(Total Thrombus Formation System:T-TAS)の血栓性疾患の評価

    三浦直樹, 岩永朋子, 齋藤靖夫, 高橋雅, 福島隆治

    日本産業動物獣医学会(九州)・日本小動物獣医学会(九州)・日本獣医公衆衛生学会(九州)   2018   2018

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  • 胸腺腫関連性剥離性皮膚炎が疑われた猫に対しシクロスポリンの単剤投与が有効であった1症例

    十川英, 蔵元智英, 高橋香, 須永隆文, 齋藤靖男, 三浦直樹, 藤木誠, 畑井仁, 三好宣彰, 一二三達郎, 一二三達郎, 高橋雅, 遠藤泰之, 遠藤泰之

    日本産業動物獣医学会(九州)・日本小動物獣医学会(九州)・日本獣医公衆衛生学会(九州)   2018   2018

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  • 犬の骨盤内膣腫瘤の術前検査としてのMRIの有用性の検討

    蔵元智英, 十川英, 須永隆文, 齋藤靖生, 三浦直樹, 一二三達郎, 一二三達郎, 畑井仁, 三好宣彰, 藤木誠, 遠藤泰之, 遠藤泰之

    日本産業動物獣医学会(九州)・日本小動物獣医学会(九州)・日本獣医公衆衛生学会(九州)   2018   2018

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  • 新規血液凝固能検査としての全血血栓形成観測システム(Total Thrombus-Formation System:T-TAS)の臨床使用例

    岩永朋子, 市川華帆, 齋藤靖生, 高橋雅, 福島隆治, 三浦直樹

    日本獣医師会獣医学術学会年次大会講演要旨集   2017   2018

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  • 文献アーカイブ―獣医学/医学の視点からー No.25-28

    三浦直樹

    伴侶動物画像診断   2 ( 6 )   99 - 101   2017.12

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  • 文献アーカイブ―獣医学/医学の視点からー No.20-24

    三浦直樹

    伴侶動物画像診断   2 ( 5 )   143 - 145   2017.10

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  • 鹿児島大学共同獣医学部附属動物病院リニューアルの目的と展望

    三浦直樹

    MPアグロジャーナル   31   12 - 15   2017.10

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  • 文献アーカイブ―獣医学/医学の視点からー No.16-19

    三浦直樹

    伴侶動物画像診断   2 ( 4 )   103 - 105   2017.8

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  • 文献アーカイブ―獣医学/医学の視点からー No.12-15

    三浦直樹

    伴侶動物画像診断   2 ( 3 )   103 - 105   2017.6

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  • 文献アーカイブ―獣医学/医学の視点からー No.9-11

    三浦直樹

    伴侶動物画像診断   2 ( 2 )   104 - 105   2017.4

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  • 文献アーカイブ―獣医学/医学の視点からー No.5-8

    三浦直樹

    伴侶動物画像診断   2 ( 1 )   103 - 105   2017.2

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  • 全血血栓形成観測システムT-TASを用いた心房細動モデル犬に対するクロピドグレルによる抗血栓治療の評価

    山田修作, 安川洋子, 河口貴恵, 橋本梨那, 大沼悠輝, 本野翔太, 永里朋香, 丸山征郎, 岩永朋子, 三浦直樹, 福島隆治

    日本獣医麻酔外科学雑誌   48 ( Supplement 2 )   2017

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  • 新規血液凝固能検査としての全血血栓形成観測システム(Total Thrombus Formation System:T-TAS)の臨床使用例

    市川華帆, 岩永朋子, 齋藤靖夫, 十川英, 蔵元智英, 古澤悠, 高橋香, 須永隆文, 高橋雅, 福島隆治, 三浦直樹

    日本産業動物獣医学会(九州)・日本小動物獣医学会(九州)・日本獣医公衆衛生学会(九州)   2017   2017

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  • 全血血栓形成観測システムT-TASを用いた心房細動モデル犬に対するダルテパリンによる抗血栓治療の効果

    安川洋子, 山田修作, 河口貴恵, 吉村有正, 橋本梨那, 大沼悠輝, 本野翔太, 永里朋香, 丸山征郎, 岩永朋子, 三浦直樹, 福島隆治

    日本獣医麻酔外科学雑誌   48 ( Supplement 1 )   2017

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  • 文献アーカイブ―獣医学/医学の視点からー No.1-4

    三浦直樹

    伴侶動物画像診断   1 ( 2 )   103 - 105   2016.12

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  • 門脈疾患における画像診断のポイント

    三浦直樹

    Comparative Animal Practice   31 ( 12 )   14 - 27   2016.12

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  • 診療ステップアップ 止血異常と血液凝固(Part3) 血液凝固疾患の新規治療薬と新規モニタリング 血栓・凝固薬のモニタリング トロンボエラストグラフィーとT-TAS

    岩永 朋子, 三浦 直樹

    J-VET   29 ( 12 )   65 - 75   2016.12

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  • 【門脈疾患の鑑別〜PSSの診断・治療アップデート〜】門脈疾患における画像診断のポイント

    三浦 直樹

    CAP: Companion Animal Practice   31 ( 12 )   14 - 27   2016.12

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  • 直ぐに分かる簡単なMRI検査の概要とイヌの脳梗塞の画像診断

    三浦直樹

    MPアグロジャーナル   27   18 - 21   2016.10

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  • 症例に学ぶ難治性疾患の診かた・考え方(Case 11) 黒毛和種子牛における下腿骨骨折の一例

    本川 裕介, 安藤 貴朗, 藤川 拓郎, 齋藤 靖生, 乙丸 孝之介, 三浦 直樹, 藤木 誠, 窪田 力

    臨床獣医   34 ( 10 )   44 - 48   2016.10

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  • 腹部エコーを読む 症例から学ぶ腹部超音波検査所見(第22回)(Case[22]) 間欠的な嘔吐を示した犬の1例

    三浦 直樹

    CLINIC NOTE   12 ( 8 )   78 - 86   2016.8

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  • 動物モデルではヒトの動脈硬化をどこまで再現できるのか? マイクロミニピッグを用いた医学研究の現状

    谷本 昭英, 川口 博明, 三好 和睦, 大竹 正剛, 三浦 直樹, 野口 倫子

    日本動脈硬化学会総会プログラム・抄録集   48回   110 - 110   2016.6

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  • Close Up! 猫の炎症マーカー 血清アミロイドA(SAA)を使いこなす! SAAの検査の現状と臨床現場での応用

    桃井 康行, 上山 裕弥, 花野 みなみ, 三浦 直樹

    CAP: Companion Animal Practice   31 ( 5 )   62 - 65   2016.5

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  • 胸部のX線画像 症例からみる胸部の画像診断(第19回)(Case19) 改善と悪化を繰り返す発咳がみられた犬の1例

    三浦 直樹

    CLINIC NOTE   12 ( 1 )   94 - 103   2016.1

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  • A Rare Case of Mediastinal T-Cell Lymphoma in a Juvenile Dog

    山崎裕毅, 川畑貴裕, 澤真理子, LAI Yu-Chang, 矢吹映, 三浦直樹

    日本獣医師会雑誌   69 ( 6 )   2016

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  • Two Cases of Primary Soft Tissue Lymphoma with Inflammation in Cats

    松永文, 山崎裕毅, 徳永暁, 十川英, 瀬戸口明日香, 三浦直樹

    日本獣医師会雑誌   69 ( 12 )   2016

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  • 症例に学ぶ難治性疾患の診かた・考え方(Case 6) 重症肺炎を発症した黒毛子牛

    帆保 誠二, 石川 真悟, 三浦 直樹

    臨床獣医   33 ( 12 )   44 - 48   2015.12

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  • バルプロ酸処理を用いた体細胞クローンマイクロミニピッグの作出

    前田昂亮, 秋岡幸兵, 野口倫子, 三浦直樹, 川口博明, 谷本昭英, 三好和睦

    日本暖地畜産学会報   58 ( 2 )   311   2015.9

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  • 腹部エコーを読む 症例から学ぶ腹部超音波検査所見(第16回)(Case16) 嘔吐を主訴に来院した猫の1例

    三浦 直樹

    CLINIC NOTE   11 ( 8 )   54 - 63   2015.8

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  • 症例に学ぶ難治性疾患の診かた・考え方(Case 3) 黒毛和種育成雌牛における尿膜管開存

    安藤 貴朗, 藤川 拓郎, 齋藤 靖生, 三浦 直樹, 窪田 力

    臨床獣医   33 ( 6 )   52 - 55   2015.6

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  • 超小型ミニブタを用いた超短期動脈硬化増強モデルの開発

    野口 倫子, 丸山 征郎, 谷本 昭英, 川口 博明, 三浦 直樹

    先進医薬研究振興財団研究成果報告集   2014年度   220 - 222   2015.3

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  • 胸部のX線画像 症例からみる胸部の画像診断(第13回)(Case13) 発咳と呼吸促迫、間欠的な嘔吐を認めた犬の1例

    三浦 直樹

    CLINIC NOTE   11 ( 1 )   83 - 94   2015.1

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  • 全血血栓形成観測システムT-TASを用いた心房細動モデル犬の心房血および末梢血における血栓形成能の継時的変化

    平尾大樹, 山田修作, 河口貴恵, 和田智樹, 島田香寿美, 丹野耕作, 永里朋香, 丸山征郎, 三浦直樹, 岩永朋子, 福島隆治

    日本獣医麻酔外科学雑誌   46 ( Supplement 2 )   2015

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  • 膵炎と肺高血圧症を併発した犬の全血血栓形成観測システムによる血小板&凝固能検査の可能性

    岩永朋子, 福島隆治, 山田修作, 平尾大樹, 永里朋香, 丸山征郎, 三浦直樹

    日本獣医麻酔外科学雑誌   46 ( Supplement 2 )   2015

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  • 呼吸困難を主訴とした子牛の唾液腺嚢胞の1例

    羽生 奈々子, 安藤 貴朗, 三浦 直樹, 藤木 誠, 川口 博明, 窪田 力

    日本獣医師会雑誌   67 ( 12 )   938 - 938   2014.12

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  • 腹部エコーを読む 症例から学ぶ腹部超音波検査所見(第11回)(Case11) 食欲低下を主訴に来院した猫の2例

    三浦 直樹

    CLINIC NOTE   10 ( 10 )   52 - 64   2014.10

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  • 犬の肝細胞癌特異的microRNAの発現変化解析

    片野田 祐介, 川口 博明, 岩永 朋子, 三好 宣彰, 桃井 康行, 三浦 直樹

    日本獣医学会学術集会講演要旨集   157回   482 - 482   2014.8

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  • Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke. (vol 14, pg 18899, 2013)

    Kiyoshi Kikuchi, Salunya Tancharoen, Takashi Ito, Yoko Morimoto-Yamashita, Naoki Miura, Ko-ichi Kawahara, Ikuro Maruyama, Yoshinaka Murai, Eiichiro Tanaka

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   15 ( 4 )   5410 - 5411   2014.4

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    DOI: 10.3390/ijms15045410

    Web of Science

  • 世界初マイクロミニピッグ動脈硬化モデルの開発 脂質代謝と系統の関連について

    三浦 直樹

    医科学応用研究財団研究報告   31   419 - 421   2014.2

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    Language:Japanese   Publisher:(公財)鈴木謙三記念医科学応用研究財団  

  • 第三の家畜 実験動物としてのミニブタ 世界最小のマイクロミニピッグ

    谷本 昭英, 川口 博明, 野口 倫子, 三浦 直樹, 大竹 正剛

    病理と臨床   32 ( 1 )   92 - 96   2014.1

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  • 第三の家畜 実験動物としてのミニブタ 世界最小のマイクロミニピッグ

    谷本 昭英, 川口 博明, 野口 倫子, 三浦 直樹, 大竹 正剛

    病理と臨床   32 ( 1 )   92 - 96   2014.1

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  • 胸部X線画像―症例から見る胸部の画像診断ー.

    三浦直樹.

    CLINIC NOTE   9 ( 10 )   59 - 67   2013.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 腹部エコーを読む 症例から学ぶ腹部超音波検査所見(第5回)(Case 5) 食欲不振を主訴に来院した猫の2例

    三浦 直樹

    CLINIC NOTE   9 ( 10 )   59 - 67   2013.10

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    Publisher:(株)エデュワードプレス  

  • 乳腺腫瘍罹患犬の血清microRNA解析

    片野田祐介, 前村忠, 川口博明, 伊藤敏生, 花野みなみ, 岩永朋子, 三好宣彰, 桃井康行, 三浦直樹

    日本獣医学会学術集会講演要旨集   156th   343 - 343   2013.8

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    Language:Japanese   Publisher:(公社)日本獣医学会  

    J-GLOBAL

  • 腹部エコーを読む―症例から学ぶ腹部超音波検査所見ー.

    三浦直樹.

    CLINIC NOTE   9 ( 1 )   8 - 14   2013.1

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  • MRIの適応と病態から知るMRIの異常所見.

    三浦直樹.

    CAP   28 ( 1 )   19 - 34   2013.1

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  • 胸部のX線画像 症例からみる胸部の画像診断(Case1) 間歇的な発作性の発咳がみられた猫の1例

    三浦 直樹

    CLINIC NOTE   9 ( 1 )   8 - 14   2013.1

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  • 【やさしく学べるMRI 正常像と読影法】MRIの適応と読影法 病態から知る異常所見

    三浦 直樹

    CAP: Companion Animal Practice   28 ( 1 )   19 - 34   2013.1

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    Language:Japanese   Publisher:(株)緑書房  

  • Secondary prevention of stroke: Pleiotropic effects of optimal oral pharmacotherapy (Review). Reviewed

    Kikuchi K, Kawahara KI, Miura N, Ito T, Morimoto Y, Tancharoen S, Takeshige N, Uchikado H, Sakamoto R, Miyagi N, Kikuchi C, Iida N, Shiomi N, Kuramoto T, Hirohata M, Maruyama I, Morioka M, and Tanaka E.

    Exp Ther Med   4 ( 1 )   3 - 7   2012.7

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  • 鹿児島県で多発する犬のシリカ尿結石についての疫学調査

    田崎 由実, 三浦 直樹, 桃井 康行

    J-VET   25 ( 5 )   20 - 23   2012.5

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  • 脊髄疾患・関節疾患の画像検査.

    三浦直樹

    CLINIC NOTE   8 ( 4 )   80 - 89   2012.4

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  • 大学病院の二次診療 鹿児島大学共同獣医学部附属動物病院<第3回> 脊髄疾患・関節疾患の画像検査

    三浦 直樹

    CLINIC NOTE   8 ( 4 )   86 - 89   2012.4

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  • マイクロミニピッグを用いた食餌性動脈硬化症モデルの開発

    青江 史貴, 山田 知信, 川口 博明, 三浦 直樹, 和泉 博之, 谷本 昭英, 三好 宣彰

    日本獣医学会学術集会講演要旨集   153回   213 - 213   2012.3

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  • Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases. Reviewed

    Kikuchi K*, Takeshige N*, Miura N*, (*These authors are equally contributed.) Mmrimoto Y, Ito T, Tancharoen S, Miyata K, Kikuchi C, Iida N, Uchikado H, Miyagi N, Shiomi N, Kuramoto T, Maruyama I, Morioka M, Kawahara K

    Exp Ther Med.   3 ( 1 )   3 - 8   2012.1

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  • 超音波画像検査を用いた牛の先天性心奇形の臨床診断

    星野友哉, 安藤貴朗, 窪田力, 三浦直樹, 岩永朋子, 川口博明, 三好宣彰

    日本産業動物獣医学会(九州)・日本小動物獣医学会(九州)・日本獣医公衆衛生学会(九州)   2012   47   2012

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    J-GLOBAL

  • 雑種犬家系に認められたサンドホフ病(GM2ガングリオシドーシス0亜型):新規病原性変異の同定

    神山萌子, 吉野吉秋, 矢吹映, 川崎安亮, 三浦直樹, 川口博明, RAHMAN Mohammad Mahbubur, 水上圭二郎, 大和修

    日本産業動物獣医学会(九州)・日本小動物獣医学会(九州)・日本獣医公衆衛生学会(九州)   2012   102   2012

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    Language:Japanese  

    J-GLOBAL

  • 虚血条件下での神経様細胞におけるエダラボンのHMGB1に対する効果

    菊池 清志, 川原 幸一, 松田 史代, 伊藤 隆史, 森元 陽子, Tancharoen Salunya, 三浦 直樹, 竹重 暢之, 折戸 公彦, 山下 伸, 内門 久明, 宮城 尚久, 塩見 直人, 倉本 晃一, 徳富 孝志, 重森 稔, 坂本 六大, 菊池 千恵美, 飯田 成美, 吉田 義弘, 橋口 照人, 丸山 征郎, 森岡 基浩, 田中 永一郎

    神経外傷   34 ( 2 )   225 - 227   2011.12

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  • Diagnostic Imaging of Cervical Vertebral Injury in a Horse

    MURATA Daiki, MIURA Naoki, MATUMOTO Mitsuharu, MIYOSHI Nobuaki, FUJIKI Makoto, MISUMI Kazuhiro

    Journal of the Japan Veterinary Medical Association   64 ( 9 )   703 - 707   2011.9

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    Language:Japanese   Publisher:Japan Veterinary Medical Association  

    An equine case of hind lameness and wobbler syndrome following an accidental forward fall during exercise was evaluated by diagnostic imaging. The myelography under general anesthesia was suggestive of a dorsally compressed spine between the sixth cervical vertebrae (C6) and C7. Histopathological findings also pointed to compression myelopathy between C6 and C7. A computed tomography scan of the cervical and thoracic (T) vertebraes following euthanasia was diagnostic of fractures of the C7 and joint space widening at the articular processes at the range from C6 to T2. Deformed alignment from C6 to T2 could induce spinal compression.

    DOI: 10.12935/jvma.64.703

    CiNii Books

  • 小動物診療のエビデンス 消化器疾患 膵炎 CT検査

    三浦 直樹

    J-VET   24 ( 7 )   19 - 24   2011.7

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  • Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral intarction. Reviewed

    Kikuchi K, Kawahara K , Uchikado H, Miyagi N, KuramotoT, Miyagi T, Morimoto Y, Ito T, Tancharoen S, Miura N, Takenouchi K, Oyama Y, Shrestha B, Matsuda F, Yoshida Y, Arimura S, Mera K, Tada K, Yoshinaga N, Maenosono R, Ohno Y, Hashiguchi T, Maruyama I, Shigemori M

    Exp Ther Med   2 ( 5 )   771 - 775   2011.5

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  • 【血栓症に関するQ&A(PART6)】血液凝固・線溶系 宿主RNAと第XII因子の関係をご説明ください

    三浦 直樹

    血栓と循環   19 ( 1 )   145 - 147   2011.3

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    Language:Japanese   Publisher:(株)メディカルレビュー社  

  • 生命科学研究に最適な非齧歯類実験動物の超小型ミニブタ 高脂肪・高コレステロール餌で誘導される新規アテローム性動脈硬化症モデル(Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet)

    Kawaguchi Hiroaki, Miyoshi Noriaki, Miura Naoki, Fujiki Makoto, Horiuchi Masahisa, Izumi Yasukatsu, Miyajima Hiroaki, Nagata Ryoichi, Misumi Kazuhiro, Takeuchi Toru, Tanimoto Akihide, Yoshida Hiroki

    Journal of Pharmacological Sciences   115 ( 2 )   115 - 121   2011.2

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    Language:English   Publisher:(公社)日本薬理学会  

  • 犬の脊柱管内脂肪織炎の画像診断例

    村田大紀, 三浦直樹, 岩永朋子, 徳永暁, 矢吹映, 三好宣彰, 北野吉秋, 桃井康行, 藤木誠

    日本獣医皮膚科学会学術大会・総会   14th ( Vol.1 )   2011

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  • 赤芽球の成熟異常により貧血を呈した猫の1例

    岩永朋子, 三浦直樹, 三浦直樹, 三好宣彰, 桃井康行

    日本獣医皮膚科学会学術大会・総会   14th ( Vol.1 )   2011

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  • 犬の膝に形成したガングリオンシストの1例

    村田大紀, 三浦直樹, 三浦直樹, 岩永朋子, 徳永暁, 矢吹映, 三好宣彰, 川口博明, 藤木誠

    日本産業動物獣医学会(九州)・日本小動物獣医学会(九州)・日本獣医公衆衛生学会(九州)   2011   113   2011

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    J-GLOBAL

  • ミノサイクリンは、虚血条件下のPC12細胞において、無酸素無糖培養が誘導するHMGB1放出とHMGB1が誘導するアポトーシスを減弱する

    菊池 清志, 川原 幸一, 内門 久明, 宮城 尚久, 倉本 晃一, 宮城 知也, 森元 陽子, 伊藤 隆史, Tancharoen Salunya, 三浦 直樹, 宮田 圭, 菊池 千恵美, 坂本 六大, 塩見 直人, 橋口 照人, 丸山 征郎, 徳富 孝志, 重森 稔

    神経外傷   33 ( 2 )   241 - 243   2010.12

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    Language:Japanese   Publisher:(一社)日本脳神経外傷学会  

  • 猫の炎症マーカー 血清アミロイドAを使ってみよう

    花野 みなみ, 三浦 直樹, 上村 利也, 野上 理加, 桃井 康行

    J-VET   22 ( 2 )   66 - 68   2009.2

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  • DICの診断 D-dimerとP-FDPの臨床応用

    古川 誠, 三浦 直樹, 曲 泰男, 上村 利也, 野上 理加, 桃井 康行

    J-VET   22 ( 1 )   70 - 72   2009.1

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  • 猫の糖尿病のモニタリングをどうするか グリコアルブミンの応用

    花野 みなみ, 三浦 直樹, 上村 利也, 野上 理加, 桃井 康行

    J-VET   21 ( 12 )   83 - 85   2008.12

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  • Possible role of transcriptional coactivator p300/CBP associated factor and nuclear acetylation in calcium-induced keratinocyte differentiation

    H Kawabata, K Kawahara, T Kanekura, N Araya, H Daitoku, M Hatta, N Miura, A Fukamizu, T Kanzaki, Maruyama, I, T Nakajima

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   119 ( 1 )   275 - 275   2002.7

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:BLACKWELL PUBLISHING INC  

    Web of Science

  • 麻酔モニター(BP-508)の終末呼気二酸化炭素分圧と平均動脈圧に対するイヌでの有効性

    藤木 誠, 三浦 直樹, 三角 一浩, 坂本 絋

    獣医麻酔外科学雑誌 = Japanese journal of veterinary anesthesia & surgery   29 ( 0 )   1998.10

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Presentations

  • Naoki Miura、Saki Hashimoto   Differential expression microRNAs in canine hepatocellular carcinoma with some similarities to human equivalents  

    2022.9 

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    Event date: 2022.9 - 2022.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • The Bio-Functional Aspect of Non-Coding Small RNA for Canine Melanoma   Invited International conference

    II. INTERNATIONAL VII. NATIONAL VETERINARY PHARMACOLOGY AND TOXICOLOGY CONGRESS  2022.9 

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    Event date: 2022.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Web (Balikesir, Turkey)   Country:Turkey  

  • 上村利也、本川絢賀、河野治郎、三浦直樹   失神を主訴とする猫の犬糸状虫症の1症例  

    令和4年度日本小動物獣医学会(九州地区)   2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web(大分県獣医師会)  

  • 橋本砂輝、森田真央、島袋泰治、亀田景子、三浦直樹   肋骨に発生した血管肉腫に対し、拡大外科切除と術後化学療法を行い長期生存している若齢犬の1例  

    令和4年度日本小動物獣医学会(九州地区)   2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web(大分県獣医師会)  

  • 杉山慶樹、杉山伸樹、三浦直樹   退形成性乏突起膠細胞腫に対して手術を行った犬の3例  

    令和4年度日本小動物獣医学会(九州地区)   2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web(大分県獣医師会)  

  • Miura N   COVID-19 impact on livestock industries and mitigation   Invited International conference

    28th Annual Scientific Conference (ASCon XXVIII) , Bangladesh Society for Veterinary Education and Research (BSVER)  2020.5  Bangladesh Veterinary Association

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    Event date: 2022.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:バングラディシュ農業大学 (Web)  

    国際学会

  • Naoki Miura   New RNA Application in Veterinary Medicine, Including Canine Tumor and Bovine Mastitis   Invited International conference

    Webinar (Dokuz Eylul University)   2022.4  Dokuz Eylul University

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    Event date: 2022.4

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Turkey  

  • Naoki Miura   Non-coding RNA in veterinary medicine: Focus on canine tumors and bovine mastitis   Invited International conference

    Webinar (Ankara University)   2022.2  Ankara University Veterinary Faculty International Relations Coordination Office

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    Event date: 2022.2

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Turkey  

  • Md. Nazmul Hasan, Md Mahfuzur Rahman, Naoki Miura   Long Non-Coding RNA And tRNA Fragments Profile in Canine Mammary Gland Tumor by Next Generation Sequencing   International coauthorship International conference

    2022.2 

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    Event date: 2022.2

    Language:English   Presentation type:Oral presentation (general)  

  • 野口亜季、岩永朋子、三浦直樹、十川英、藤木誠   総胆管胆石による胆道穿孔をみとめ胆嚢欠損と臨床診断した猫の1例  

    令和3年度日本小動物獣医学会(九州地区)   2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web  

  • 橋本砂輝、森田真央、島袋泰治、亀田景子、猪狩和明、高橋義明、三浦直樹   猫の鼻腔内リンパ腫20例における治療法と予後の検討  

    令和3年度日本小動物獣医学会(九州地区)   2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web  

  • 上村利也、本川絢賀、河野治郎、三浦直樹、町田登   肺高血圧症を呈した肥大型心筋症罹患犬の2例  

    令和3年度日本小動物獣医学会(九州地区)   2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web  

  • 杉山慶樹、杉山伸樹、三浦直樹   椎間板ヘルニア犬54例における血漿CPKとCRPの進行性脊髄軟化症との関連性の検討  

    令和3年度日本小動物獣医学会(九州地区)   2021.10 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web  

  • Md. Nazmul Hasan, Al Asmaul Husna, Md Mahfuzur Rahman, Hui-Wen Chen, Naoki Miura   Long non-coding RNA derived small RNA fragments in canine mammary malignant tumor   International conference

    SaSSOH 2021, The 9th SapporoSummer Seminor for One healt  2021.9 

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    Event date: 2021.9

    Language:English   Presentation type:Poster presentation  

    Venue:web開催  

    国際学会

  • Yasunori Hino, Md. Mahfuzur Rahman, Al Asmaul Husna, Hui-Wen Chen, Md. Nazmul Hasan, Takayuki Nakagawa, Naoki Miura   Hypoxic non-coding RNA signature in canine oral melanoma   International conference

    SaSSOH 2021, The 9th SapporoSummer Seminor for One healt  2021.9 

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    Event date: 2021.9

    Language:English   Presentation type:Poster presentation  

    Venue:web開催  

    国際学会

  • 野崎 信裕、矢吹 映、三浦 直樹   脳脊髄液検査(cerebrospinal fluid: CSF)で蛋白細胞解離が見られた症例のMRI画像検査との関連性  

    日本獣医臨床病理学会2021年次大会  2021.8 

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    Event date: 2021.8 - 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催  

  • 古澤 悠、十川 英、徳持雄太、齋藤靖生、高橋 雅、三浦直樹、大和 修、矢吹 映   細胞診および免疫細胞化学染色により診断された鼻腔内髄外性形質細胞腫の犬の1例  

    日本獣医臨床病理学会2021年次大会  2021.8 

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    Event date: 2021.8 - 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催  

  • 岩永朋子,齋藤靖生,畑井 仁,永里朋香,伊藤隆史,福島隆治,高橋 雅,細川和也,三浦直樹,丸山征郎   LPS投与ウサギモデルにおけるDIC前段階の血小板と白血球の可視化による評価  

    第43回日本血栓止血学会学術集会  2021.5 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web  

  • Naoki Miura,   Veterinary research and educational program in Kagoshima University   Invited International conference

    5th International Symposium, Association of Japan-Indonesia Veterinary Education (AJIVE)  2021.2 

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    Event date: 2021.2

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:web開催  

    国際学会

  • Hui-Wen Chen, Yu-Chang Lai, Md. Mahfuzur Rahman, Al Asmaul Husna, Md. Nazmul Hasan, Naoki Miura,   DOWN-REGULATED MIR-1-3P AND MIR-133 FAMILY IN CANINE MAMMARY GLAND TUMOR   International conference

    5th International Symposium, Association of Japan-Indonesia Veterinary Education (AJIVE)  2021.2 

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    Event date: 2021.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:web開催  

    国際学会

  • Naoki Miura,   Veterinary research and educational program in Kagoshima University   International conference

    5th International Symposium, Association of Japan-Indonesia Veterinary Education (AJIVE)  2021.2 

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    Event date: 2021.2

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:web開催  

    国際学会

  • Md. Mahfuzur Rahman, Yu-Chang Lai, Al Asmaul Husna, Hui-Wen Chen, Md. Nazmul Hasan, Nobuhiro Nozaki, and Naoki Miura   DIFFERENTIALLY EXPRESSED MICRORNAS RECOGNIZE FAST AND SLOW PROGRESSING CANINE HEPATOCELLULAR CARCINOMA   International conference

    5th International Symposium, Association of Japan-Indonesia Veterinary Education (AJIVE)  2021.2 

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    Event date: 2021.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:web開催  

    国際学会

  • Al Asmaul Husna, Md. Mahfuzur Rahman, Yu-Chang Lai, Hui-Wen Chen, Md. Nazmul Hasan, and Naoki Miura   IDENTIFICATION OF TUMOR SPECIFIC EXOSOMAL MIRNAS BY PROFILING CANINE ORAL MELANOMA   International conference

    5th International Symposium, Association of Japan-Indonesia Veterinary Education (AJIVE)  2021.2 

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    Event date: 2021.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:web開催  

    国際学会

  • 井尻萌、Yu-Chang Lai、三浦直樹、藤本佳万、松尾智英、川口博明   ブタの大きさの指標としての多脊椎数関連遺伝子NR6A1の有用性  

    第163回日本獣医学会学術集会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山口大学(web開催)  

  • Md. Mahfuzur Rahman、Yu-Chang Lai、Al Asmaul Husna、Hui-Wen Chen、Md. Nazmul Hasan、中川貴之、三浦直樹   Identification of hypoxia-regulated miRNA signature in canine oral melanoma  

    第163回日本獣医学会学術集会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山口大学(web開催)  

  • Al Asmaul Husna、Md. Mahfuzur Rahman、Yu-Chang Lai、Hui-Wen Chen、Md. Nazmul Hasan、中川貴之、三浦直樹、   Exosomal miRNAs profile in canine oral melanoma  

    第163回日本獣医学会学術集会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山口大学(web開催)  

  • Hui-Wen Chen、Yu-Chang Lai、Md. Mahfuzur Rahman、Al Asmaul Husna、Md. Nazmul Hasan、畑井仁、三好宣彰、三浦直樹   MicroRNAs differential expression profile in Canine Mammary Gland Tumor by Next-Generation Sequencing  

    第163回日本獣医学会学術集会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山口大学(web開催)  

  • 岩崎隆、Md. Mahfuzur Rahman、Yu-Chang Lai、Al Asmaul Husna、Hui-Wen Chen、Md. Nazmul Hasan、野崎信裕、畑井仁、三好宣彰、三浦直樹   MicroRNA transcriptome profile of canince hepatocellular carcinoma  

    第163回日本獣医学会学術集会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山口大学(web開催)  

  • 岩永朋子、齋藤靖生、畑井仁、永里朋香、伊藤隆史、丸山征郎、三浦直樹   LPS誘導ウサギDICモデルにおけるDIC世s器の血小板の動向:血栓形成の可視化による検索  

    第163回日本獣医学会学術集会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山口大学(web開催)  

  • Miura N   The application of small non-coding RNA in the veterinary field. Primarily focus the transcriptome analysis in canine tumor and bovine mastitis   Invited International conference

    26th Annual International Scientific Conference (ASCon XXVI) , Bangladesh Society for Veterinary Education and Research (BSVER)  Bangladesh Veterinary Association

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    Event date: 2020.2 - 2020.3

    Language:English   Presentation type:Oral presentation (keynote)  

    Venue:バングラディシュ農業大学  

    国際学会

  • 多々良蒼真、三浦直樹   無麻酔CT検査の方法と診断能・適応症など有用性の検討  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 高橋香、三浦直樹、齋藤靖生、十川英、蔵元智英、畑井仁、一二三達郎、三好宣彰、藤木誠、桃井康行、遠藤泰之   歯性感染症により骨破壊を伴う炎症性腫瘤が形成された猫の2症例  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 上村利也、古川絢賀、瀬戸山健太郎、三浦直樹、町田登   肺高血圧を呈した犬9例における肺の病理組織  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 高橋香、三浦直樹、齋藤靖生、十川英、蔵元智英、畑井仁、一二三達郎、三好宣彰、藤木誠、桃井康行、遠藤泰之   歯性感染症により骨破壊を伴う炎症性腫瘤が形成された猫の2症例  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 上村利也、古川絢賀、瀬戸山健太郎、三浦直樹、町田登   肺高血圧を呈した犬9例における肺の病理組織  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 橋本砂輝、森田真央、島袋泰治、亀田景子、三浦直樹   猫の足根部に発生した皮膚型リンパ腫の1例  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 岩永朋子、高橋香、蔵元智英、十川英、齋藤靖生、三浦直樹、畑井仁、一二三達郎、三好宣彰、桃井康行   原発性上皮小体機能亢進症の犬4例におけるCT検査の検討  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 古澤悠、須永隆文、畑井仁、一二三達郎、三好宣彰、三浦直樹   超音波検査とCT検査で臨床診断した全身性アミロイドーシスの猫の1例  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 橋本砂輝、森田真央、島袋泰治、亀田景子、三浦直樹   猫の足根部に発生した皮膚型リンパ腫の1例  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 多々良蒼真、三浦直樹   無麻酔CT検査の方法と診断能・適応症など有用性の検討  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 高橋香、三浦直樹、齋藤靖生、十川英、蔵元智英、畑井仁、一二三達郎、三好宣彰、藤木誠、桃井康行、遠藤泰之   歯性感染症により骨破壊を伴う炎症性腫瘤が形成された猫の2症例  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 上村利也、古川絢賀、瀬戸山健太郎、三浦直樹、町田登   肺高血圧を呈した犬9例における肺の病理組織  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 岩永朋子、高橋香、蔵元智英、十川英、齋藤靖生、三浦直樹、畑井仁、一二三達郎、三好宣彰、桃井康行   原発性上皮小体機能亢進症の犬4例におけるCT検査の検討  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 古澤悠、須永隆文、畑井仁、一二三達郎、三好宣彰、三浦直樹   超音波検査とCT検査で臨床診断した全身性アミロイドーシスの猫の1例  

    令和元年度⽇本⼩動物獣医学会(九州地区)第68回九州地区獣医師⼤会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランデはがくれ(佐賀県)  

  • 酒匂夏美、三浦直樹、谷崎ゆり、佐野あすか、谷村明香里、助広和隆、松元大地、原田実咲希、一丸由里子、古市汐美、大山愛史、遠藤泰之   猫の投薬における投薬器使用の推進  

    第15回日本獣医内科学アカデミー(JCVIM2019) 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜  

  • Miura N   small noncoding RNA (microRNA) as a new biomarkers in bovine mastitis.   Invited International conference

    BIT's 7th Annual World Congress of Food and Nutrition-2018 

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    Event date: 2018.11

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Holiday Inn Singapore Atrium  

  • 三浦直樹、岩永朋子、齋藤靖夫、高橋雅、福島隆治   全血血栓形成観測システム(Total Thrombus Formation System: T-TAS)の血栓性疾患の評価  

    平成30年度⽇本⼩動物獣医学会(九州地区)第67回九州地区獣医師⼤会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場  

  • 宮ノ前琢磨、三浦直樹、安藤貴朗、窪田力   牛の新規耳標装着器による耳片採取の活用  

    平成30年度⽇本産業動物獣医学会(九州地区)第67回九州地区獣医師⼤会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場  

  • 蔵元智英、十川 英、須永隆文、齋藤靖男、三浦直樹、 一二三達郎、畑井 仁、三好宣彰、藤木 誠、遠藤泰之   犬の骨盤内膣腫瘤の術前検査としてのMRIの有用性の検討  

    平成30年度⽇本⼩動物獣医学会(九州地区)第67回九州地区獣医師⼤会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場  

  • 十川 英、蔵元智英、高橋 香、須永隆文、齋藤靖男、三浦直樹、藤木 誠、 一二三達郎、畑井 仁、三好宣彰、高橋 雅、遠藤泰之   胸腺腫関連性剥離性皮膚炎が疑われた猫に対しシクロスポリンの単剤投与が有効であった1症例  

    平成30年度⽇本⼩動物獣医学会(九州地区)第67回九州地区獣医師⼤会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場  

  • 杉山慶樹、藁戸由樹、三浦直樹、杉山伸樹   神経及び筋生検後に多発性ニューロパシーを疑った犬の1例  

    平成30年度⽇本⼩動物獣医学会(九州地区)第67回九州地区獣医師⼤会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場  

  • 橋本 砂輝、森田 真央、島袋 泰治、亀田 景子、三浦 直樹   常用電圧X線発生装置による緩和的放射線治療を行った犬の口腔内悪性メラノーマ12症例  

    平成30年度⽇本⼩動物獣医学会(九州地区)第67回九州地区獣医師⼤会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場  

  • 緒方和子、阿部真宇、山之内忠幸、松田秀雄、玄優基、三浦直樹、橋谷田豊   ウシ精子の非凍結低温保存における不凍ポリアミノ酸および抗酸化剤の効果  

    第111回日本繁殖生物学会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:信州大学  

  • Lai YC, Lai YT, Rahman MM, Fujikawa T, Ando T, Kitahara G, Koiwa M, Kubota C, Miura N.   Application of microRNA biomarkers in Bovine Mastitis Milk.   International conference

    The 30th World Buiatrics Congress.  

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    Event date: 2018.8 - 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue: Sapporo Convention Center  

  • Miura N   The application of small non-coding RNA in the veterinary field. especially focus the transcriptome analysis in canine tumor and microRNA expression in bovine mastitis.   Invited International conference

    The 2nd Veterinary Medicine International Conference 2018 in Collaboration with ADPRC-OHCC"New Wave Bio-X Veterinary Medicine""Strengthen on One Health, Biomedical, Reproduction, Nutrition and Clinical Science".  

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    Event date: 2018.7

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:niversity Airlangga  

  • Miura N   Transcriptome Analysis (include microRNA and mRNA)of Canine Melanoma, Hepatocellular Carcinoma, Mammary Gland Tumor.   Invited International conference

    1st International Congress on Enviroment and Animal Health: Linking endocrine disrupters, epigenetics, biotechnology for cancer in animals.  

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    Event date: 2018.4

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Ankara University  

  • 陳田 能央、永吉 貴子、坂本 紘、中島 利博、三浦 直樹   ミトコンドリア活性をターゲットとした新規サプリメントの犬の肥満に対する効果の検証  

    第14回日本獣医内科学アカデミー 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜  

  • 窪田力、三浦直樹、藤川拓郎、玄丞烋   黒毛和牛の受精卵・精子の凍結保存  

    第17回日本再生医療学会総会 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:パシフィコ横浜  

  • 谷村 明香里、三浦 直樹、岩永 朋子、遠藤 泰之   鹿児島大学動物病院で行っている無麻酔CT検査における保定法  

    第14回日本獣医内科学アカデミー 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜  

  • 岩永朋子, 市川華帆, 齋藤靖夫, 十川英, 蔵元智英, 古澤悠, 高橋香, 須永隆文, 高橋雅, 福島隆治, 三浦直樹   新規?液凝固能検査としての全??栓形成観測システム(Total Thrombus- Formation System:T-TAS)の臨床使?例  

    平成29年度日本獣医師会獣医学術学会年次大会 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:別府国際コンベンションセンター  

  • Md. Mahfuzur Rahman, Yu-Chang Lai, Norio Ushio, Yukiko Tanaka, Hitoshi Hatai, Takayuki Nakagawa, Noriaki Miyoshi, Naoki Miura   microRNA-mRNA transcriptomic crosstalk of canine melanoma  

    第40回日本分子生物学会年会 

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    Event date: 2017.12

    Language:English   Presentation type:Poster presentation  

    Venue:神戸ポートアイランド  

  • 本川祐介、藤川拓郎、綿屋健太、川崎安亮、乙丸孝之介、安藤貴明、三浦直樹、窪田力   起立困難を呈した黒毛和種牛のX線、CTおよびMRI検査による画像診断  

    第38回動物臨床医学会年次⼤会 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪国際会議場  

  • 陣田能央, 齋藤靖夫, 蔵元智英, 三浦直樹   脳梗塞と診断した犬の臨床症状、画像検査(CT、MRI)の特徴の評価  

    平成29年度日本小動物獣医学会(九州地区)第66回九州地区獣医師大会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄コンベンションセンター  

  • 市川華帆, 岩永朋子, 齋藤靖夫, 十川英, 蔵元智英, 古澤悠, 高橋香, 須永隆文, 高橋雅, 福島隆治, 三浦直樹   新規血液凝固能検査としての全血血栓形成観測システム(Total Thrombus- Formation System:T-TAS)の臨床使用例  

    平成29年度日本小動物獣医学会(九州地区)第66回九州地区獣医師大会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄コンベンションセンター  

  • 川口博明, 安藤貴朗, 畑添至, 入來俊久, 古賀周治, 山田峰也, 中武貞文, 小澤真, 三浦直樹, 谷本昭英   ICTによる24時間牛体温遠隔モニターシステムの開発  

    第160回日本獣医学会学術集会  日本獣医学会

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島市  

  • Y. Kakihanaa, C. Kamikokuryoa, H. Furubeppua, Y. Madokoroa, T. Futatsukia, S. Miyamotoa, H. Harauraa, K. Hatanakaa, Y. Saitob, N. Miurab, H. Suzukic, Y. Uedac, T. Yasudaa, T. Itoa   Monitoring of brain oxygenation during and after cardiopulmonary resuscitation - A prospective porcine study   International conference

    45th. Annual meeting of ISOTT in Halle  the International Society on Oxygen Transport to Tissue (ISOTT)

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    Event date: 2017.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Halle, Germany  

  • 三浦直樹   牛の臨床ー画像診断の今ー  

    九州産業動物臨床研究会  九州産業動物臨床研究会

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    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:佐賀市  

  • Tomoko Iwanaga, Shusaku Yamada, Ryuji Fukushima, Tomoka Nagasato, Ikuro Maruyama, Naoki Miura   Novel Thrombogenicity Examination of Whole Blood: Total Thrombus-formation Analysis System in Dogs   International conference

    ACVIM 2017  ACVIM

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    Event date: 2017.6

    Language:English   Presentation type:Poster presentation  

    Venue:National Harbor, MD, USA  

  • 安川洋子, 山田修作, 河口貴恵, 平尾大樹, 橋本梨那, 長里朋香, 丸山征郞, 三浦直樹, 岩永朋子, 福島隆治   出血傾向を全血血栓形成観測システム(T-TAS)により確認できた犬の3 例  

    第37回動物臨床医学会年次大会  動物臨床医学会

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪国際会議場  

  • 三浦直樹,賴 昱璋,安藤貴朗,北原豪,小岩政照,窪田 力   牛乳房炎乳汁の新規バイオマーカー候補マイクロRNA探索  

    第37回動物臨床医学会年次大会  動物臨床医学会

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪国際会議場  

  • 安藤貴朗, 本川裕介, 本藤川拓郎, 齋藤靖男, 乙丸孝之介, 三浦直樹, 藤木 誠, 窪田力   下腿骨骨折に対して髄内ピンと外固定を併用した黒毛和種子牛の一例  

    平成28年度日本産業動物獣医学会(九州地区)第65回九州地区獣医師大会  日本獣医師会

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千草ホテル、北九州市  

  • 本川裕介, 乙丸孝之介, 五位塚勝利, 藤川拓郎, 斉藤靖生, 畑井仁, 安藤貴朗, 三浦直樹, 三好宣彰, 窪田力   黒毛和種子牛の腹部体表にみられたメラノサイトーマの一例  

    平成28年度日本産業動物獣医学会(九州地区)第65回九州地区獣医師大会  日本獣医師会

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千草ホテル、北九州市  

  • 蔵元智英, 十川英, 藤木誠, 三浦直樹   術中急性脳梗塞が強く疑われた犬の1例  

    平成28年度日本小動物獣医学会(九州地区)第65回九州地区獣医師大会  日本獣医師会

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千草ホテル、北九州市  

  • 十川英, 須永隆文, 松尾智英, 三浦直樹, 遠藤泰之   CT検査が有用であった犬の肺吸虫症の2例  

    平成28年度日本小動物獣医学会(九州地区)第65回九州地区獣医師大会  日本獣医師会

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千草ホテル、北九州市  

  • 窪田力、三浦直樹、藤川拓郎、玄丞烋   黒毛和牛の受精卵・精子の凍結保存  

    第17回日本再生医療学会総会 

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    Event date: 2013.3 - 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜  

  • 村田大紀、吉田年伸、宮田健二、三浦直樹、松元光春、三好宣彰、藤木誠、三角一浩   ウマの頚椎損傷に対する画像診断検査の1例  

    日本ウマ科学会 第23回 学術集会  日本ウマ科学会 第23回 学術集会

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    Event date: 2010.11

    Language:Japanese  

    Venue:東京  

    国内学会

  • 德永 暁、政岡和彦、新井 恒、村田大紀、三浦直樹、矢吹 映、藤木 誠、三角一浩   肺扁平上皮癌により肥大性骨症を発症した犬の治療経過  

    平成22年度 日本小動物獣医学会  平成22年度 日本小動物獣医学会

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    Event date: 2010.10

    Language:Japanese  

    Venue:長崎  

    国内学会

  • 村田大紀、吉田年伸、宮田健二、三浦直樹、松元光春、三好宣彰、藤木誠、三角一浩   ウマの頚椎損傷に対する画像診断検査の1例  

    平成22年度 九州地区三学会  平成22年度 九州地区三学会

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    Event date: 2010.10

    Language:Japanese  

    Venue:長崎  

    国内学会

  • Kikuchi Kikuchi、Naohisa Miyagi、Ko-ichi Kawahara、Yoko Morimoto、Naoki Miura、Teruto Hashiguchi、IkuroMaruyama、 Hisaaki Uchikado   Edaravone attenuates the cerebral ischemic injury by inhibiting aquaporine-4   International conference

    第29回国際臨床神経生理学会  第29回国際臨床神経生理学会

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    Event date: 2010.10

    Language:English  

    Venue:神戸  

    国際学会

  • 菊池清志、 宮城尚久、 内門久明、川原幸一、森元陽子、三浦直樹、橋口照人、丸山征郎、徳富孝志、重森稔   Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells  

    第25回日本脊髄外科学会  第25回日本脊髄外科学会

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    Event date: 2010.6

    Language:Japanese  

    Venue:名古屋  

    国内学会

  • Binita Shrestha, Teruto Hashiguchi, Takashi Ito, Naoki Miura, Kazunori Takenouchi, Yoko Oyama, Ko-ichi Kawahara, Salunya Tancharoen, Yuya Ki-i, Noboru Arimura, Narimasa Yoshinaga, Satoshi Noma, Takao Nitanda, Shinichi Kitajima, Kimiyoshi Arimura, Masahiro Sato, Taiji Sakamoto and Ikuro Maruyama.   Immunomodulatory role of VEGF-A  

    第33回日本血栓止血学会学術集会  第33回日本血栓止血学会学術集会

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    Event date: 2010.4

    Language:Japanese  

    Venue:鹿児島  

    国内学会

  • 菊池清志、川原幸一、Kamal Krishna Biswas、伊藤隆史、三浦直樹、森元陽子、田島裕、倉本晃一、中山顕児、橋口照人、丸山征郎、 重森稔   The effect of Minocycline on HMGB1 in PC12 cells  

    第33回日本血栓止血学会学術集会  第33回日本血栓止血学会学術集会

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    Event date: 2010.4

    Language:Japanese  

    Venue:鹿児島  

    国内学会

  • Kiyoshi Kikuchi, Ko-ichi Kawahara, Yoko Morimoto, Naoki Miura, Teruto Hashiguchi, Ikuro Maruyama, Yutaka Tajima, Hisaaki Uchikado, Terukazu Kuramoto, Kenji Nakayama, Minoru Shigemori   Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells   International conference

    2nd International Congress of Asia Oceania Neurotrauma Society  2nd International Congress of Asia Oceania Neurotrauma Society

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    Event date: 2010.3

    Language:English  

    Venue:Tokyo  

    国際学会

  • 菊池清志、宮城尚久、川原幸一、森元陽子、三浦直樹、橋口照人、丸山征郎、徳富孝志、重森稔   無酸素無糖条件下での神経様細胞におけるミノサイクリンのHMGB1に対する効果  

    第33回日本神経外傷学会  第33回日本神経外傷学会

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    Event date: 2010.3

    Language:Japanese  

    Venue:東京  

    国内学会

  • 伊藤敏生、三浦直樹、桃井康行   三叉神経痛が疑われた猫の一例  

    日本獣医内科アカデミー 2010年大会  日本獣医内科アカデミー 2010年大会

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    Event date: 2010.2

    Language:Japanese  

    Venue:東京  

    国内学会

  • 仁位紀生、三浦直樹、藤木 誠、桃井康行   脊髄疾患が疑われるイヌに対する無麻酔CT検査の有用性   International conference

    日本獣医内科アカデミー 2010年大会  日本獣医内科アカデミー 2010年大会

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    Event date: 2010.2

    Language:English  

    Venue:東京  

    国際学会

  • 菊池清志、川原幸一、Kamal Krishna Biswas、伊藤隆史、Salunya Tancharoen、森元陽子、三浦直樹、大山陽子、竹之内和則、名和由布子、孟 暁潔、Binita Shrestha、鮫島寿代、大野佳子、前之園隆一、田島裕、倉本晃一、中山顕児、重森稔、橋口照人、丸山征郎   Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells  

    第32回日本分子生物学会  第32回日本分子生物学会

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    Event date: 2009.12

    Language:Japanese  

    Venue:横浜  

    国内学会

  • 德永 暁、上窪良和、川崎安亮、三浦直樹、藤木 誠、三角一浩   連続背側椎弓切除術を行った頚椎不安定症の犬の1例  

    平成21年度 日本小動物獣医学会 九州地区大会  平成21年度 日本小動物獣医学会 九州地区大会

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    Event date: 2009.10

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 井ノ口義哲、川口博明、宮本陽子、三好宣彰、三浦直樹、德永暁、藤木誠、三角一浩、堀内正久、金子直樹、宮嶌宏彰、安田宣紘   高脂肪および高コレステロール食によるマイクロミニピッグ動脈硬化モデルの作出  

    第58回 九州地区獣医師大会並びに平成21年度日本獣医三学会(九州)  第58回 九州地区獣医師大会並びに平成21年度日本獣医三学会(九州)

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    Event date: 2009.10

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 菊池清志、川原幸一、伊藤隆史、森元陽子、三浦直樹、田島裕、倉本晃一、橋口照人、丸山征郎、中山顕児、重森稔   PC12細胞を用いた虚血モデルにおけるミノサイクリンの効果  

    日本脳神経外科学会 第68回学術総会  日本脳神経外科学会 第68回学術総会

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    Event date: 2009.10

    Language:Japanese  

    Venue:東京  

    国内学会

  • 菊池清志、川原幸一、Salunya Tancharoen、松田史代、伊藤隆、Kamal K Biswa、竹之内和則、大山陽子、名和由布子、三浦直樹、有村昇、孟暁潔、Binita Shrestha、田島裕、倉本晃一、中山顕児、重森稔、吉田義弘、橋口照人、丸山征郎   新規脳梗塞のマーカー;HMGB1  

    第56回日本臨床検査医学会学術集会  第56回日本臨床検査医学会学術集会

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    Event date: 2009.8

    Language:Japanese  

    Venue:北海道  

    国内学会

  • Binita Shrestha, Teruto Hashiguchi, Takashi Ito, Naoki Miura, Kazunori Takenouchi, Yoko Oyama, Ko-ichi Kawahara, Yuya Ki-i, Noboru Arimura, Narimasa Yoshinaga, Satoshi Noma, Takao Nitanda, Shinichi Kitajima, Kimiyoshi Arimura, Masahiro Sato, Taiji Sakamoto and Ikuro Maruyama.   B cell-derived VEGF-A promotes lymphangiogenesis in lymph nodes but suppresses the ensuing immune responses.  

    The 56th National Congress of Japanese Society of Laboratory Medicine  The 56th National Congress of Japanese Society of Laboratory Medicine

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    Event date: 2009.7

    Language:Japanese  

    Venue:札幌  

    国内学会

  • 花野みなみ、三浦直樹、上村利也、野上理加、神保聖一、桃井康行   猫の糖尿病モニタリングをどうするか?-グリコアルブミンの応用-  

    日本獣医内科アカデミー 2009年大会  日本獣医内科アカデミー 2009年大会

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    Event date: 2009.2

    Language:Japanese  

    Venue:東京  

    国内学会

  • 古川誠、三浦直樹、曲泰男、神保聖一、上村利也、野上理加、桃井康行   DICの診断 -D-dimerとP-FDPの臨床応用-   International conference

    日本獣医内科アカデミー 2009年大会  日本獣医内科アカデミー 2009年大会

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    Event date: 2009.2

    Language:English  

    Venue:東京  

    国際学会

  • 三浦直樹、川原幸一、橋口照人、丸山征郎.   HMGB1&amp;CpG-DNAによる血管内皮細胞への警告 -遺伝子発現プロファイリング解析から見えてきたものー.  

    第30回日本分子生物学会  第30回日本分子生物学会

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    Event date: 2007.12

    Language:Japanese  

    Venue:神奈川  

    国内学会

  • 川原幸一、ビスワズ カマル、伊藤隆史、菊池清志、森元陽子、大山陽子、竹之内和則、名和由布子、孟暁潔、有村昇、スレタ ビニタ、清水利昭、三浦直樹、橋口照人、丸山征郎.   CRP induces High Mobility Group Box-1 Protein Release through activation of p38MAPK in macrophage cell line RAW264.7 cells.  

    第30回日本分子生物学会  第30回日本分子生物学会

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    Event date: 2007.12

    Language:Japanese  

    Venue:神奈川  

    国内学会

  • 菊池清志、川原幸一、Salunya Tancharoen、松田史代、森元陽子、伊藤隆史、竹之内和則、大山陽子、Kamal K Biswas、清水利昭、岩田政宏、名和由布子、孟 暁潔、有村 昇、三浦直樹、Binita Shrestha、有村真一郎、重森稔、 吉田義弘、橋口照人、丸山征郎   フリーラディカルスカベンジャーの効果と新規治療法の可能性  

    第25回 Cytoprotection研究会  第25回 Cytoprotection研究会

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    Event date: 2007.3

    Language:Japanese  

    Venue:京都  

    研究会

  • 川原幸一、橋口照人、伊藤隆史、菊池清志、森元陽子、大山陽子、三浦直樹、名和由布子、孟暁潔、竹之内和則、有村昇、Kamal Krishna Biswas、 BinitaShrestha、清水利昭、丸山征郎.   海洋深層水がエンドトキシン刺激によるHMGB1の細胞外への放出を抑制する.  

    日本予防医学会学術総会  日本予防医学会学術総会

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    Event date: 2007.1

    Language:Japanese  

    Venue:鹿児島  

    国内学会

  • Miura N, Saunders CP, Huang L, Stromberg AJ, MacLeod JN.   Transcriptional profiling of equine chondrocytes under hypoxic culture conditions.   International conference

    Plant and Animal Genome XIV  Plant and Animal Genome XIV

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    Event date: 2006.1

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

  • Miura N, Laurie R. Goodrich LR, Misumi K, Burton-Wurster N, Nixon AJ, MacLeod JN.   Fibronectin Concentration Increases in Synovial Fluid Following Articular Cartilage Injury.   International coauthorship International conference

    the American Association of Equine Practitioners  the American Association of Equine Practitioners

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    Event date: 2004.2

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

  • 本川 裕介, 藤川 拓郎, 綿屋 健太, 川崎 安亮, 乙丸 孝之介, 安藤 貴朗, 三浦 直樹, 窪田 力   起立困難を呈した黒毛和種子牛のX線、CTおよびMRI検査による画像診断  

    動物臨床医学会年次大会プロシーディング  2017.11  動物臨床医学会

  • Rahman Md Mahfuzur, Lai Yu-Chang, Ushio Norio, Tanaka Yukiko, Hatai Hitoshi, Nakagawa Takayuki, Miyoshi Noriaki, Miura Naoki   イヌのメラノーマに関するmicroRNA-mRNAのトランスクリプトームクロストーク(microRNA-mRNA transcriptomic crosstalk of canine melanoma)  

    生命科学系学会合同年次大会  2017.12  生命科学系学会合同年次大会運営事務局

  • Al Asmaul Husna, Rahman Md. Mahfuzur, Lai Yu-Chang, Chen Hui-Wen, Hasan Md. Nazmul, 中川 貴之, 三浦 直樹   イヌ口腔メラノーマにおけるエクソソームのmiRNAプロファイリング(Exosomal miRNAs profile in canine oral melanoma)  

    日本獣医学会学術集会講演要旨集  2020.10  (公社)日本獣医学会

  • Rahman Md. Mahfuzur, Lai Yu-Chang, Al Asmaul Husna, Chen Hui-Wen, Hasan Md. Nazmul, 中川 貴之, 三浦 直樹   イヌ口腔メラノーマにおける低酸素環境下でのmiRNAシグネチャーの同定(Identification of hypoxia-regulated miRNA signature in canine oral melanoma)  

    日本獣医学会学術集会講演要旨集  2020.10  (公社)日本獣医学会

  • 岩崎 隆, Rahman Md. Mahfuzur, Lai Yu-Chang, Al Asmaul Husna, Chen Hui-Wen, Hasan Md. Nazmul, 野崎 信裕, 畑井 仁, 三好 宣彰, 三浦 直樹   イヌ肝細胞癌のマイクロRNAトランスクリプトームプロファイル(MicroRNA transcriptome profile of canine hepatocellular carcinoma)  

    日本獣医学会学術集会講演要旨集  2020.10  (公社)日本獣医学会

  • 緒方 和子, 阿部 真宇, 山之内 忠幸, 藤川 拓郎, 松田 秀雄, 田村 慎之介, 橋谷田 豊, 林 正和, 玄 優基, 玄 丞烋, 三浦 直樹, 窪田 力   ウシ精子の液状保存における保存温度および細胞保護物質の添加の影響  

    日本畜産学会大会講演要旨集  2019.3  (公社)日本畜産学会

  • 緒方 和子, 阿部 真宇, 山之内 忠幸, 松田 秀雄, 玄 優基, 三浦 直樹, 橋谷田 豊   ウシ精子の非凍結低温保存における不凍ポリアミノ酸および抗酸化剤の効果  

    The Journal of Reproduction and Development  2018.9  (公社)日本繁殖生物学会

  • 山崎 裕毅, 三浦 直樹, 船山 麻理菜, 岩田 宗峻, 平田 翔吾, 三重 慧一郎, 島村 俊介, 秋吉 秀保, 嶋田 照雅   リン酸トセラニブを用いた犬の腺癌に対する術後補助療法の検討  

    日本獣医麻酔外科学雑誌  2018.6  (一社)日本獣医麻酔外科学会

  • 山田 修作, 安川 洋子, 河口 貴恵, 橋本 梨那, 大沼 悠輝, 本野 翔太, 永里 朋香, 丸山 征郎, 岩永 朋子, 三浦 直樹, 福島 隆治   全血血栓形成観測システムT-TASを用いた心房細動モデル犬に対するクロピドグレルによる抗血栓治療の評価  

    日本獣医麻酔外科学雑誌  2017.11  (一社)日本獣医麻酔外科学会

  • 安川 洋子, 山田 修作, 河口 貴恵, 吉村 有正, 橋本 梨那, 大沼 悠輝, 本野 翔太, 永里 朋香, 丸山 征郎, 岩永 朋子, 三浦 直樹, 福島 隆治   全血血栓形成観測システムT-TASを用いた心房細動モデル犬に対するダルテパリンによる抗血栓治療の効果  

    日本獣医麻酔外科学雑誌  2017.6  (一社)日本獣医麻酔外科学会

  • Chen Hui-Wen, Lai Yu-Chang, Rahman Md. Mahfuzur, Al Asmaul Husna, Hasan Md. Nazmul, 畑井 仁, 三好 宣彰, 三浦 直樹   次世代シーケンスを用いたイヌ乳腺腫瘍におけるマイクロRNA発現の違いに関する検討(Micro RNAs differential expression profile in Canine Mammary Gland Tumor by Next-Generation Sequencing)  

    日本獣医学会学術集会講演要旨集  2020.10  (公社)日本獣医学会

  • 岩永 朋子, 齋藤 靖生, 畑井 仁, 永里 朋香, 伊藤 隆史, 福島 隆治, 高橋 雅, 丸山 征郎, 三浦 直樹   LPS誘導ウサギDICモデルにおけるDIC初期の血小板の動向 血栓形成の可視化による検索  

    日本獣医学会学術集会講演要旨集  2020.10  (公社)日本獣医学会

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  • 岩永 朋子, 福島 隆治, 山田 修作, 平尾 大樹, 永里 朋香, 丸山 征郎, 三浦 直樹   膵炎と肺高血圧症を併発した犬の全血血栓形成観測システムによる血小板&凝固能検査の可能性  

    日本獣医麻酔外科学雑誌  2015.12  (一社)日本獣医麻酔外科学会

  • 菊池 清志, 宮城 尚久, 川原 幸一, 森元 陽子, 三浦 直樹, 橋口 照人, 丸山 征郎, 徳富 孝志, 重森 稔   脳脊髄外傷の基礎的研究(神経損傷の基礎シンポジウム) 無酸素無糖条件下での神経様細胞におけるミノサイクリンのHMGB1に対する効果  

    日本脳神経外傷学会プログラム・抄録集  2010.3  (一社)日本脳神経外傷学会

  • Kikuchi Kiyoshi, Kawahara Ko-ichi, Miyagi Naohisa, Morimoto Yoko, Miura Naoki, Matsuda Fumiyo, Yoshida Yoshihiro, Uchikado Hisaaki, Hashiguchi Teruto, Maruyama Ikuro, Shigemori Minoru   脳梗塞ラットにおけるHMGB1に対するedaravoneの効果(Effects of Edaravone on HMGB1 in Rats with Cerebral Infarction)  

    Circulation Journal  2011.3  (一社)日本循環器学会

  • 柘植 彩, 西口 明博, 遠藤 泰之, 川崎 安亮, 三浦 直樹, 瀬戸口 明日香, 矢吹 映, 桃井 康行   猫のクリプトコックス症に対する血清学的検査の有用性  

    動物臨床医学会年次大会プロシーディング  2014.11  動物臨床医学会

  • 山崎 裕毅, Lai Yu-Chang, 立野 守洋, 越野 裕子, 瀬戸口 明日香, 遠藤 泰之, 中市 統三, 辻本 元, 三浦 直樹   犬リンパ腫における低酸素環境標的療法の開発に関する基礎的研究  

    日本獣医学会学術集会講演要旨集  2016.8  (公社)日本獣医学会

  • 濱田 亜以, 三浦 直樹, 桃井 康行   犬の肥満細胞腫におけるKITの発現  

    動物臨床医学会年次大会プロシーディング  2013.11  動物臨床医学会

  • 片野田 祐介, 川口 博明, 岩永 朋子, 三好 宣彰, 桃井 康行, 三浦 直樹   犬の肝細胞癌特異的microRNAの発現変化解析  

    日本獣医学会学術集会講演要旨集  2014.8  (公社)日本獣医学会

  • 長谷川 喬彬, 大西 朋子, 鮫島 寿代, 細川 和也, 三浦 直樹, 伊藤 隆史, 小出 武比古, 田中 健一, 丸山 征郎   抗IIa薬(dabigartran)と抗Xa薬(rivaroxaban)の血流下及び非血流下における抗血栓能の解析  

    日本血栓止血学会誌  2013.4  (一社)日本血栓止血学会

  • 羽生 奈々子, 安藤 貴朗, 三浦 直樹, 藤木 誠, 川口 博明, 窪田 力   呼吸困難を主訴とした子牛の唾液腺嚢胞の1例  

    日本獣医師会雑誌  2014.12  (公社)日本獣医師会

  • 宮本 早紀子, 西口 明博, 飯倉 陵, 杉山 大輔, 曲 泰男, 伊藤 源太, 三浦 直樹, 桃井 康行   各疾患におけるD-dimerの臨床応用と検討  

    動物臨床医学会年次大会プロシーディング  2014.11  動物臨床医学会

  • 谷本 昭英, 川口 博明, 三好 和睦, 大竹 正剛, 三浦 直樹, 野口 倫子   動物モデルではヒトの動脈硬化をどこまで再現できるのか? マイクロミニピッグを用いた医学研究の現状  

    日本動脈硬化学会総会プログラム・抄録集  2016.6  (一社)日本動脈硬化学会

  • 平尾 大樹, 山田 修作, 河口 貴恵, 和田 智樹, 島田 香寿美, 丹野 耕作, 永里 朋香, 丸山 征郎, 三浦 直樹, 岩永 朋子, 福島 隆治   全血血栓形成観測システムT-TASを用いた心房細動モデル犬の心房血および末梢血における血栓形成能の継続的変化  

    日本獣医麻酔外科学雑誌  2015.12  (一社)日本獣医麻酔外科学会

  • 橋口 照人, 伊藤 隆史, スレスタ・ビニタ , 三浦 直樹, 丸山 征郎   免疫B細胞発現VEGF-Aによるリンパ節リモデリングと免疫環境の機能的制御  

    日本血栓止血学会誌  2012.4  (一社)日本血栓止血学会

  • 山崎 裕毅, Lai Yu-Chang, 瀬戸口 明日香, 越野 裕子, 中市 統三, 辻本 元, 三浦 直樹   低酸素培養条件下の犬リンパ腫細胞における生物学的活性の解析  

    日本獣医学会学術集会講演要旨集  2015.8  (公社)日本獣医学会

  • 十川 英, 徳永 暁, 下川 孝子, 三浦 直樹, 藤木 誠   門脈体循環シャントに対するセロハンバンド設置後に血小板減少を呈した犬の1例  

    動物臨床医学会年次大会プロシーディング  2013.11  動物臨床医学会

  • 野口 倫子, 丸山 征郎, 谷本 昭英, 川口 博明, 三浦 直樹   超小型ミニブタを用いた超短期動脈硬化増強モデルの開発  

    先進医薬研究振興財団研究成果報告集  2015.3  (公財)先進医薬研究振興財団

  • スレスタ・ビニタ , 橋口 照人, 伊藤 隆史, 三浦 直樹, 竹之内 和則, 吉永 成就, 川原 幸一, 佐藤 正弘, 坂本 泰二, 丸山 征郎   血管増殖因子VEGF-Aは獲得免疫環境を制御する  

    臨床病理  2009.7  (一社)日本臨床検査医学会

  • 三浦 直樹, 大西 朋子, 鮫島 寿代, 長谷川 喬彬, 永里 朋香, 細川 和也, 伊藤 隆史, 小出 武比古, 丸山 征郎   血流下における血小板血栓形成能を指標とした抗血小板薬抵抗性の解析  

    日本血栓止血学会誌  2013.4  (一社)日本血栓止血学会

  • Kikuchi Kiyoshi, Kawahara Ko-ichi, Morimoto Yoko, Tancharoen Salunya, Miura Naoki, Takeshige Nobuyuki, Uchikado Hisaaki, Miyagi Naohisa, Kuramoto Terukazu, Morioka Motohiro   虚血性脳卒中モデルラットのAQP4に対するエダラボンの影響(Effects of Edaravone on AQP4 in Rats with Ischemic Stroke)  

    臨床薬理  2011.10  (一社)日本臨床薬理学会

  • Tanimoto Akihide, Kawaguchi Hiroaki, Miura Naoki, Miyoshi Noriaki   世界最小のマイクロミニブタ 新規アテローム硬化易発性ミニブタ(The world smallest Microminipigs: A novel atherosclerosis-prone miniature pigs)  

    日本動脈硬化学会総会プログラム・抄録集  2013.6  (一社)日本動脈硬化学会

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  • Miyamoto Atsushi, Islam Md. Zahorul, Kawaguchi Hiroaki, Miura Naoki, Yamzaki-Himeno Emi, Shiraishi Mitsuya, Miyoshi Noriaki, Tanimoto Akihide   マイクロミニブタ脳底動脈反応性に対するアンジオテンシンII静脈内持続投与の影響(Effect of continuous intravenous infusion of angiotensin II on Microminipig basilar arterial responsiveness)  

    Journal of Pharmacological Sciences  2013.3  (公社)日本薬理学会

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  • 三浦 直樹   マイクロミニブタ動脈硬化モデルでの炎症性サイトカインHMGB1と血栓傾向の関連  

    血液医学研究年報  2014.3  (公財)先進医薬研究振興財団

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  • Islam Md. Zahorul, Nishimura Miharu, Kawaguchi Hiroaki, Miura Naoki, Iwanaga Tomoko, Yamazaki-Himeno Emi, Shiraishi Mitsuya, Miyoshi Noriaki, Tanimoto Akihide, Miyamoto Atsushi   マイクロミニブタの血圧と血管作動性物質に対する脳底動脈の応答性にアンジオテンシンIIの継続的な静注が及ぼす影響(Effect of continuous intravenous infusion of angiotensin II on blood pressure and basilar arterial responsiveness to vasoactive substances in Microminipig)  

    日本獣医学会学術集会講演要旨集  2012.8  (公社)日本獣医学会

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  • 青江 史貴, 山田 知信, 川口 博明, 三浦 直樹, 和泉 博之, 谷本 昭英, 三好 宣彰   マイクロミニピッグを用いた食餌性動脈硬化症モデルの開発  

    日本獣医学会学術集会講演要旨集  2012.3  (公社)日本獣医学会

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  • 井尻 萌, Lai Yu-Chang, 三浦 直樹, 藤本 佳万, 松尾 智英, 川口 博昭   ブタの大きさの指標としての多脊椎数関連遺伝子NR6A1の有用性  

    日本獣医学会学術集会講演要旨集  2020.10  (公社)日本獣医学会

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  • 川原 幸一, 菊池 清志, 岩田 政宏, 伊藤 隆史, 瀬戸山 健太郎, 上村 亮三, 大山 陽子, 竹之内 和則, カマル・クリシュナン・ビシュワズ , 清水 利昭, 名和 由布, 孟 暁潔, サランヤータンジャロン , ビニタスレスタ , 有村 昇, 三浦 直樹, 高尾 尊身, 橋口 照人, 丸山 征郎   ヒトリンパ細胞はブタ内皮細胞を標的・活性化しHigh Mobility Group Box 1(HMGB1)を発現誘導する  

    移植  2007.6  (一社)日本移植学会

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  • 村田 大紀, 徳永 暁, 宮越 大輔, 畠添 孝, 三浦 直樹, 藤木 誠, 中山 功一, 三角 一浩   ウマ滑液由来間葉系幹細胞の培養とその性質  

    日本獣医学会学術集会講演要旨集  2014.8  (公社)日本獣医学会

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  • 三浦 直樹, 三角 一浩, 川原 幸一, 中島 三保子, 川畑 久, 岡 達三, 丸山 征郎, 坂本 紘   ウマのVascular Endothelial Growth Factor(VEGF)のクローニングとリコンビナント蛋白の作成  

    日本獣医学会学術集会講演要旨集  2001.3  (公社)日本獣医学会

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  • Islam Md. Zahorul, Yamazaki-Himeno Emi, Shiraishi Mitsuya, Miyamoto Atsushi, Kawaguchi Hiroaki, Miyoshi Noriaki, Miura Naoki, Tanimoto Akihide   アンジオテンシンIIはミニブタの培養脳底動脈内皮細胞でブラジキニンに誘発されるNO放出量を減少させプロスタグランジンF2αの放出量を増加させる(Angiotensin II decreases bradykinin-induced NO and increases prostaglandin F2α release from cultured Microminipig basilar arterial endothelial cells)  

    Journal of Pharmacological Sciences  2014.2  (公社)日本薬理学会

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  • 上村 亮, 鈴木 秀作, 三浦 直樹, 坂本 紘, 宮原 健吉, 塩見 雅志   WHHLウサギの肝臓,腎臓,肺における流入血管及び実質内血管病変  

    日本獣医学会学術集会講演要旨集  1999.9  (公社)日本獣医学会

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  • スレスタ・ビニタ , 橋口 照人, 伊藤 隆史, 三浦 直樹, 竹之内 和則, 大山 陽子, 川原 幸一, タンジャルーン・サランヤー , 貴井 裕哉, 有村 昇, 吉永 就正, 野間 聖, 二反田 隆夫, 北島 信一, 有村 公良, 佐藤 正宏, 坂本 泰二, 丸山 征郎   VEGF-Aの免疫調節的役割(Immunomodulatory role of VEGF-A)  

    日本血栓止血学会誌  2010.4  (一社)日本血栓止血学会

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  • 山田 修作, 平尾 大樹, 河口 貴恵, 和田 智樹, 島田 香寿美, 丹野 耕作, 永里 朋香, 丸山 征郎, 岩永 朋子, 三浦 直樹, 福島 隆治   T-TASを用いたイヌの心房細動時における急性期の血液凝固能の評価  

    日本獣医麻酔外科学雑誌  2015.12  (一社)日本獣医麻酔外科学会

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  • 瀬戸山 健太郎, 新里 健, 三浦 直樹, 三角 一浩, 坂本 紘   Propofol-Sevoflurane麻酔の母体胎仔の血行動態へ及ぼす影響  

    獣医麻酔外科学雑誌  2001.7  (一社)日本獣医麻酔外科学会

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  • 菊池 清志, 宮城 尚久, 川原 幸一, 倉本 晃一, 森元 陽子, 三浦 直樹, 橋口 照人, 丸山 征郎, 重森 稔   PC12細胞におけるHMGB1の効果(The effect of HMGB1 in PC12 cells)  

    Brain Tumor Pathology  2011.5  日本脳腫瘍病理学会

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  • 菊池 清志, 川原 幸一, ビシュワズ・クリシュナ・カマル , 伊藤 隆史, 三浦 直樹, 森元 陽子, 田島 裕, 倉本 晃一, 中山 顕児, 橋口 照人, 丸山 征郎, 重森 稔   PC12細胞におけるHMGB1に対するミノサイクリンの作用(The effect of Minocycline on HMGB1 in PC12 cells)  

    日本血栓止血学会誌  2010.4  (一社)日本血栓止血学会

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  • 鮫島 寿代, 大西 朋子, 長谷川 喬彬, 三浦 直樹, 細川 和也, 伊藤 隆史, 小出 武比古, 丸山 征郎   PAR1阻害剤及びPAR4阻害剤の血流下及び非血流下における抗血栓効果の解析  

    日本血栓止血学会誌  2012.4  (一社)日本血栓止血学会

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  • 岩永 朋子, 齋藤 靖生, 畑井 仁, 永里 朋香, 伊藤 隆史, 福島 隆治, 高橋 雅, 細川 和也, 三浦 直樹, 丸山 征郎   LPS投与ウサギモデルにおけるDIC前段階の血小板と白血球の可視化による解析  

    日本血栓止血学会誌  2021.5  (一社)日本血栓止血学会

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  • 三浦 直樹, 後田 徹志, 鈴木 秀作, 三角 一浩, 梅元 千代志, 三好 宣彰, 坂本 紘   LEC(Long-Evans Cinnamon)ラットの肝炎発症に及ぼす交流高圧電位負荷の影響  

    日本獣医学会学術集会講演要旨集  2001.3  (公社)日本獣医学会

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  • 川口 博明, 安藤 貴朗, 畑添 至, 入來 俊久, 古賀 周治, 山田 峰也, 中武 貞文, 小澤 真, 三浦 直樹, 谷本 昭英   ICTによる24時間牛体温遠隔モニターシステムの開発  

    日本獣医学会学術集会講演要旨集  2017.8  (公社)日本獣医学会

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  • 菊池 清志, 川原 幸一, びしゅわず・かまるくりしゅなん , 伊藤 隆史, 三浦 直樹, たんじぇろん・さらんやー , 森元 陽子, 田島 裕, 倉本 晃一, 中山 顕児, 橋口 照人, 丸山 征郎, 重森 稔   HMGB1に対するミノサイクリンの効果  

    日本生化学会大会プログラム・講演要旨集  2009.9  (公社)日本生化学会

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  • 菊池 清志, 森元 陽子, 三浦 直樹, 伊藤 隆史, 名和 由布子, 坂本 六大, 宮城 尚久, 倉本 晃一, 川原 幸一   HMGB1 新規脳梗塞バイオマーカー  

    日本臨床内科医会会誌  2011.9  (一社)日本臨床内科医会

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  • Kamimura Ryozo, Miura Naoki, Suzuki Syusaku   Clawnミニブタにおける肺血液動態(Pulmonary hemodynamics in the Clawn miniature pigs)  

    Experimental Animals  2003.4  (公社)日本実験動物学会

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  • 鈴木 雄大, 三浦 直樹, Binita Shrestha, 伊藤 隆史, 竹之内 和則, 山口 宗一, 桃井 康行, 橋口 照人   B細胞特異的VEGF-A過剰発現マウスのリンパ組織の構造変化、免疫応答と脾臓のトランスクリプトーム(mRNA & microRNA)解析  

    日本獣医学会学術集会講演要旨集  2013.8  (公社)日本獣医学会

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  • 堀内 正久, 川口 博明, 武石 嘉一朗, 三好 宣彰, 三浦 直樹, 叶内 宏明, 有村 恵美, 青山 公治, 竹内 亨   世界最小ミニブタ(マイクロミニピッグ)の栄養学実験への応用 動脈硬化モデルの確立と活動量解析  

    日本病態栄養学会誌  2010.11  (一社)日本病態栄養学会

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  • 田崎 由実, 三浦 直樹, 桃井 康行   鹿児島県で多発するイヌのシリカ結石についての報告  

    ペット栄養学会誌  2011.10  (一社)日本ペット栄養学会

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  • Kawaguchi Hiroaki, Miyoshi Noriaki, Fujiki Makoto, Miura Naoki, Horiuchi Masahisa, Itoh Katzuhiko, Kaneko Naoki, Miyajima Hiroaki, Nagata Ryoichi, Misumi Kazuhiro, Yasuda Nobuhiro   高脂肪・高コレステロール食によるマイクロミニブタの動脈硬化症モデル(Microminipig atherosclerosis model by high fat and cholesterol-diet)  

    Journal of Pharmacological Sciences  2010.2  (公社)日本薬理学会

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  • Morishita Satoru, Kawaguchi Hiroaki, Ono Tomoji, Miura Naoki, Murakoshi Michiaki, Sugiyama Keikichi, Kato Hisanori, Tanimoto Akihide, Nishino Hoyoku   高コレステロール血症に対するラクトフェリンの効果(第1報) ミニブタを用いた食餌誘発性アテローム性動脈硬化症モデルにおける高コレステロール血症に対するラクトフェリンの抑制効果(Effect of lactoferrin on hypercholesterolemia, 1st report: Preventive effect of lactoferrin on hypercholesterolemia in a diet-induced atherosclerosis model using Microminipigs)  

    日本栄養・食糧学会大会講演要旨集  2015.5  (公社)日本栄養・食糧学会

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  • 菊池 清志, 川原 幸一, 宮城 尚久, 倉本 晃一, 森元 陽子, 三浦 直樹, 橋口 照人, 丸山 征郎, 重森 稔   虚血条件下での神経様細胞におけるエダラボンのHMGB1に対する効果  

    日本脳神経外傷学会プログラム・抄録集  2011.3  (一社)日本脳神経外傷学会

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  • 坂本 紘, 三角 一浩, 新里 健, 青木 修, 瀬戸山 健太郎, 三浦 直樹, 柳田 宏一   肉用牛の輸送ストレスに対する削蹄の効果  

    家畜診療  2001.10  (公社)全国農業共済協会

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  • 田崎 由実, 伊藤 源太, 三浦 直樹, 桃井 康行   犬のシリカ尿結石好発地域におけるシリカ結石の成因と予防方法  

    ペット栄養学会誌  2012.7  (一社)日本ペット栄養学会

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  • 三浦 直樹, 頼 いく璋, 安藤 貴朗, 北原 豪, 小岩 政照, 窪田 力   牛乳房炎乳汁の新規バイオマーカー候補マイクロRNA探索  

    動物臨床医学会年次大会プロシーディング  2016.11  動物臨床医学会

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  • Kawaguchi Hiroaki, Miyoshi Noriaki, Miura Naoki, Horiuchi Masahisa, Ono Tomoji, Murakoshi Michiaki, Nishino Hoyoku, Nagata Ryoichi, Sahara Hisashi, Tanimoto Akihide, Yamada Kazuhiko, Yoshida Hiroki   日本製超小型ミニブタ(Microminipig) 医学研究ツールとしての展開 Microminipig 心血管疾患に立ち向かう研究モデル(An extremely small size mini-pig made in Japan (MicrominipigTM): evolution as a medical research tool Microminipig: research models to break through cardiovascular disease)  

    Journal of Pharmacological Sciences  2011.2  (公社)日本薬理学会

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  • 岩永 朋子, 市川 華帆, 齋藤 靖生, 高橋 雅, 福島 隆治, 三浦 直樹   新規血液凝固能検査としての全血血栓形成観測システム(Total Thrombus-Formation System:T-TAS)の臨床使用例  

    日本獣医師会雑誌  2018.11  (公社)日本獣医師会

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  • 菊池 清志, 川原 幸一, Salunya Tancharoen, 松田 史代, 伊藤 隆史, Biswas Kamal K., 竹之内 和則, 大山 陽子, 名和 由布子, 三浦 直樹, 有村 昇, 孟 暁潔, Binita Shrestha, 田島 裕, 倉本 晃一, 中山 顕児, 重森 稔, 吉田 義弘, 橋口 照人, 丸山 征郎   新規脳梗塞のマーカー;HMGB1  

    臨床病理  2009.7  (一社)日本臨床検査医学会

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  • Islam Md. Zahorul, Nishimura Miharu, Kawaguchi Hiroaki, Miura Naoki, Iwanaga Tomoko, Yamazaki-Himeno Emi, Shiraishi Mitsuya, Miyoshi Noriaki, Tanimoto Akihide, Miyamoto Atsushi   培養豚脳底動脈内皮細胞においてアンジオテンシンII処置はブラジキニンによる一酸化窒素を減少させ、ブプロスタグランジンPGF2α産生を増加させる(Treatment of angiotensin II decreased NO and increased prostaglandin PGF2a production by bradykinin in cultured porcine basilar arterial endothelial cells)  

    日本獣医学会学術集会講演要旨集  2013.8  (公社)日本獣医学会

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  • 安川 洋子, 山田 修作, 河口 貴恵, 平尾 大樹, 末松 正弘, 橋本 梨那, 永里 朋香, 丸山 征郎, 三浦 直樹, 岩永 朋子, 福島 隆治   出血傾向を全血血栓形成観測システム(T-TAS)により確認できた犬の3例  

    動物臨床医学会年次大会プロシーディング  2016.11  動物臨床医学会

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  • 三浦 直樹, 前村 忠, 北原 豪, 片野田 佑介, 宮本 早紀子, 鎌田 立, 村田 望, 安藤 貴朗, 桃井 康行   乳房炎診断マーカーとしての特異的microRNA発現解析の可能性  

    日本獣医学会学術集会講演要旨集  2013.8  (公社)日本獣医学会

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  • 三浦 直樹, 伊藤 隆史, 川口 博明, 永里 朋香, 細川 和也, 三好 宣彰, 谷本 昭英, 丸山 征郎   世界最小富士マイクラピッグ動脈硬化モデルによる高脂血症と血栓形成能に関する検討  

    日本血栓止血学会誌  2012.4  (一社)日本血栓止血学会

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  • 井尻 萌, 尾堂 憲司, 佐藤 元彦, 川口 麻依子, 藤本 佳万, 三浦 直樹, 松尾 智英, 侯 徳興, 大和 修, 田邊 隆, 川口 博明   暑熱環境で飼養される肥育豚における潜在的ストレスマーカーの検討  

    日本獣医学会学術集会講演要旨集  2021.9  (公社)日本獣医学会

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Awards

  • 令和4年度 日本小動物獣医学会(九州地区) 九州連会長賞

    2022.9   日本獣医師会九州地区学会   退形成性乏突起膠細胞腫に対して手術を行った犬の3例

    杉山慶樹、杉山伸樹、三浦直樹(責任演者)

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 令和3年度 日本小動物獣医学会(九州地区) フレッシュアワード賞

    2021.9   日本獣医師会九州地区学会   椎間板ヘルニア犬54例における血漿CPKとCRPの進行性脊髄軟化症との関連性の検討

    杉山慶樹、杉山伸樹、三浦直樹(責任演者)

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • Best Presentation

    2021.2   5th International Symposium, Association of Japan-Indonesia Veterinary Education (AJIVE)   IDENTIFICATION OF TUMOR SPECIFIC EXOSOMAL MIRNAS BY PROFILING CANINE ORAL MELANOMA

    Al Asmaul Husna, Md. Mahfuzur Rahman, Yu-Chang Lai, Hui-Wen Chen, Md. Nazmul Hasan, and Naoki Miura (Corresponding)

  • JCVIM2019 看護アワード

    2019.2   日本獣医内科アカデミー  

    酒匂夏美、三浦直樹、谷崎ゆり、佐野あすか、谷村明香里、助広和隆、松元大地、原田実咲希、一丸由里子、古市汐美、大山愛史、遠藤泰之

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  • 第67回九州地区獣医師大会 九州地区獣医師会連合会会長賞

    2018.10   日本獣医師会九州地区学会   常用電圧X線発生装置による緩和的放射線治療を行った犬の口腔内悪性メラノーマ12症例

    橋本 砂輝、森田 真央、島袋 泰治、亀田 景子、三浦 直樹

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  • 第67回九州地区獣医師大会 九州地区獣医師会小動物部門フレッシュアワード賞

    2018.10   日本獣医師会九州地区学会   神経及び筋生検後に多発性ニューロパシーを疑った犬の1例

    杉山慶樹、藁戸由樹、三浦直樹、杉山伸樹

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  • 平成29年度日本小動物獣医学会 九州地区大会 九州地区学会長賞受賞

    2017.10   日本小動物獣医学会   新規血液凝固能検査としての全血血栓形成観測システム(Total Thrombus- Formation System:T-TAS)の臨床使用例

    市川華帆, 岩永朋子, 齋藤靖夫, 十川英, 蔵元智英, 古澤悠, 高橋香, 須永隆文, 高橋雅, 福島隆治, 三浦直樹

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  • 平成13年度日本小動物獣医学会 九州地区大会 九州地区学会長賞受賞

    2001.10   日本小動物獣医学会   イヌの完全房室ブロックへ永久ペースメーカーを適用した一例

    三浦 直樹

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  • 平成10年度日本小動物獣医学会 九州地区大会 九州地区学会長賞受賞

    1998.10   日本小動物獣医学会   猫の尺骨に発生した bone cyst の一例

    三浦 直樹

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Research Projects

  • 犬腫瘍トランスクリプトームの人工知能解析による病態関連因子の探索と臨床応用

    Grant number:21H02366  2021.4 - 2024.3

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

  • Identification of diagnostic and therapeutic molecular targets in canine tumors - th e interplay of genetics, pathology and artificial intelligence International coauthorship

    2020.4 - 2024.3

    Japan Society for the Promotion of Science  

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000

  • 乳汁中マイクロRNAを利用した牛乳の品質管理と疾病診断

    2022.9 - 2022.11

    日本学術振興会  外国人研究者招へい事業 

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  • 播種性血管内凝固症候群(DIC)における血液凝固と炎症に関する研究

    2022.4 - 2023.3

    藤森工業株式会社  共同研究  共同研究

    岩永朋子、齋藤靖生

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    Grant amount:\2000000 ( Direct Cost: \1400000 、 Indirect Cost:\600000 )

  • 牛乳中の細胞外小胞体の有効活用に関する研究

    2022.3 - 2025.3

    清川秋夫育英奨学財団  研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2900000 ( Direct Cost: \2697000 、 Indirect Cost:\203000 )

  • Identify tumor specific exosomal RNA biomarkers for skin cancer

    2021.1

    CLARA Biotech  Future Exosome Leaders 

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  • Rapid and specific diagnosis for tumor using exosome and cfDNA

    Grant number:20K21375  2020.7 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)  Grant-in-Aid for Challenging Research (Exploratory)

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    Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )

  • Mechanism elucidation of methotrexate arteriosclerosis exacerbation with human atherosclerosis pig model

    Grant number:20K06395  2020.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  • Research on the interaction of histones in pathophysiology of sepsis and its application

    Grant number:18H02906  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

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    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

  • Establishment of smart-diagnosis&treatment for canine tumor by exosome

    Grant number:17H03926  2017.4 - 2020.3

    JSPA  KAKEN  Grant-in-Aid for Scientific Research (B)

    Miura Naoki

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    Grant amount:\12500000 ( Direct Cost: \12500000 、 Indirect Cost:\3750000 )

    We studied the small-non-coding RNA and mRNA that change specifically in canine tumors to development for new diagnosis and treatment strategy. We also analyzed the tumor-specific exosome as well. As a result, we discovered RNA molecules that cause specific alternative expression in several different canine tumors using the next-generation sequence technology. We also identified the deferentially expressed small-non-coding RNA in the exosome from melanoma. This deferentially expressed pattern depends on the melanoma development and metastasis condition. Finally, we also found the similarities of RNA molecule expression pattern between humans and dogs with our transcriptome data.

  • Mechanism of the development of pancreatitis due to heart failure in dogs and establishment of new treatment methods

    Grant number:17K08100  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Fukushima Ryuji

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    A high rate of pancreatitis has been reported in dogs exhibiting heart failure (HF). In the past, the occurrence of pancreatitis has also been reported to accompany reductions in cardiac function in the treatment of humans. Therefore, along with clarifying the mechanism by which HF causes pancreatic cell damage, we aimed to establish a new treatment based on this mechanism. Our results clarified that the reduction in cardiac output and blood pressure in dogs during HF periods causes a reduction in pancreatic blood flow. We have also confirmed that the resulting decrease in zymogen granules in the pancreatic acinar cells is accompanied by the occurrence of cell atrophy. Based on these results, we were able to confirm the maintenance of pancreatic blood flow and a reduction in pathological changes due to the administration of pimobendane. We expect to establish a new method of treatment for pancreatic malfunction on this basis.

  • The evaluation of novel examination of diagnosis of Disseminated intravascular coagulation (DIC) in dogs

    Grant number:16K08054  2016.10 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Iwanaga Tomoko

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    According to the novel blood coagulation examination in dogs, we assessed the repeatability and the effect of anticoagulation drugs in vivo and in vitro using Total Thrombus formation Analysis System (T-TAS) for the healthy control dogs in the first year. Next, we assessed the risk of bleeding in the perioperative period. We compared with this bleeding risk and the phenomenon of bleeding using measurements of APTT, PT, and T-TAS. Additionally, we assessed the risk of Disseminated Intravascular Coagulation (DIC) of systemic inflammation diseases like pancreatitis using the marker of thrombosis. And we assessed platelet aggregation in cardiology patients.

  • 新たな細胞保護技術の活用と高付加価値・優良産子の増殖による肉用牛・乳用牛生産基盤強化

    2016.10 - 2019.9

    農林水産省(農林水産省技術会議)  「革新的技術開発・緊急展開事業」(うち地域戦略プロジェクト)  研究分野名:(畜産)肉用牛、乳用牛

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\138682000

  • 新たな細胞保護技術の活用と高付加価値・優良産子の増殖による肉用牛・乳用牛生産基盤強化

    2016.10 - 2019.9

    農林水産省(農林水産省技術会議)  「革新的技術開発・緊急展開事業」(うち地域戦略プロジェクト) 

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    Authorship:Principal investigator 

  • キルギスでのリウマチ熱蔓延の危険因子の分子疫学的解析と拠点集落でのその制圧の試み

    Grant number:16H05845  2016.4 - 2020.3

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    中島 利博, 川原 幸一, 西 順一郎, 三浦 直樹

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    Grant amount:\17160000 ( Direct Cost: \13200000 、 Indirect Cost:\3960000 )

    キルギスではRheumatic fever: (以下、RF)が未だに猛威を奮っている。さらに、顕在化しない RF の後遺症も含めたRheumatic heart diseases (以下、RHD) が食生活 (肉食、ウオッカ)、環境因子 (低酸素) と併せて当該地域での死因の過半数を占める 60 歳までの心不全の潜在的リスクファクターであることを報告していた。10年を超える継続的な医療支援によりキルギスのほぼ全土を網羅する詳細なフィールド調査を行い、RF/RHD の有無、心エコーなど理学的所見、溶連菌など細菌感染症の頻度、家族歴など100を超える項目に関する調査を完遂していた。その結果より、バイオマス燃料による粘膜免疫の低下がその一因であることが推測された。本研究では、新たに呼吸器分野の専門家を加え、両者に共通する感染の遷延化・慢性化に対する宿主因子の探索を行っている。
    平成30年度は、RF/RHD専門家による2回の、呼吸器内科による1回の疫学調査を行った。これらの調査を通じ。PM2.5 測定のみならず、その防御法の効果の検証を開始した。また、RF/RHD 予防・治療を啓蒙するためのキルギス語によるプロトコールを作成してきたが、昨年度末に完成した。キルギスに訪問した際に、JICAによる頒布の協力が得られることとなった。啓蒙活動の一環として、アジア・太平洋リウマチ学会が中央アジアで最初に主催した「APLAR’S EXTENSIVE COURSE ON RHEUMATOLOGY」に我が国からオーガナイザーの一人として唯一参加し、キルギスのみならず中央アジアのリウマチの専門家に対して本課題の重要性を報告した。また、RF/RHDの後遺症としての心血管障害に対する取り組みとしてリハビリテーションの重要性が明らかとなったため、Zhantai Shambetov医師を招聘し、3か月のトレーニングを行った。

  • Production of gene-modified pig of next-generation model for Alzheimer's disase

    Grant number:16H05176  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Tanimoto Akihide, NOGUCHI michiko, OHTAKE masayoshi

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    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

    To understand the pathogenesis of lifestyle disease and disorder in higher brain function, a development of proper animal model, which is similar to human pathogenesis, is necessary. In addition to the anatomy and physiology, pig is very comparable to human in its life style, food habit and brain function. We have already established a human type atherosclerosis model using microminipigs by feeding high fat diet. On the other hand, Alzheimer's diseases are increasing in number of patients. To clarify the pathogenesis and development of a novel drug for Alzheimer's disease is urgent task in Japan. Our research that are going to produce a gene-modified microminipig having Alzheimer's pathology would contribute to overcome the disease. By the present study, the understanding and accumulation of our fundamental knowledge for reproductive physiology, embryo transfer and clone technology to prepare the Alzheimer's disease-reproducing gene-modified microminipig extensively proceeded.

  • The mechamism of novel alarmin

    Grant number:16K15770  2016.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Kawahara Ko-ichi

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    Grant amount:\3380000 ( Direct Cost: \2600000 、 Indirect Cost:\780000 )

    Nucleophosmin (NPM), which is a nucleoprotein, is major multifunctional protein involved in ribosomal biogenesis, centrosome duplication, cell cycle progression, apoptosis, and cell differentiation. Recently, NPM is released from endotoxin-stimulated macrophages and induces inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6, suggesting that NPM might be an alarmin. In this study, to administer NPM to mouse, we established vectors of full-length NPM and found that the recombinant (r) NPM induced TNF-alpha in mouse macrophage-like RAW264.7 cells. In the next step, we are going to administer rNPM to mouse.

  • Functional analysis of Exosome in Canine Tumor

    Grant number:15K14872  2015.4 - 2017.3

    JSPA  KAKEN  Grant-in-Aid for Challenging Exploratory Research

    Miura Naoki

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    In the present study, we seek the new molecular bio-marker for diagnosis and treatment of dog tumor. We focus specially exosome molecule which has been identified as small follicle released from tumor. We successfully isolated exosome from dog blood by ultra centrifuge. Isolated dog exosome express surface antigen as similar as human exosome. We also investigated the expression of micro RNA in dog tumor. Micro RNA has been intensively focused in human cancer biology. We can successfully identified the unique microRNAs in several dog tumor. Finally, we can measure the microRNA expression in exosome by quantitative real-time PCR.

  • Evaluation of blood clotting ability and anti-thrombotic treatment effect during atrial fibrillation in dogs using T-TAS

    Grant number:26450425  2014.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Fukushima Ryuji, IWANAGA Tomoko, YAMADA Shusaku, KAWAGUCHI Takae, Hirao Daiki

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    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    Application of Total Thrombus-formation Analysis System(T-TAS)on dogs revealed the observation of changes in property of blood within the right atrium, more specifically, the progression of hemostatic ability and anti-thrombotic effect, which were observed 30 minutes after the onset of atrial fibrillation (AF). Additionally, it became apparent that this phenomenon lasted for the duration of the AF and resolved a week after the cessation of AF. However, these phenomena could not be observed at the peripheral (saphenous veins) blood. Either, Dalteparin or Clopidogrel was administered to dogs presented with these AF, but the progression of platelet function and Coagulation factor function within the atrium could not be suppressed

  • The analysis of inflammasome activation in extracellular histones

    Grant number:26293387  2014.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Kawahara Ko-ihi

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    Grant amount:\15990000 ( Direct Cost: \12300000 、 Indirect Cost:\3690000 )

    Recently, extracellular histones are damage-associated molecular patterns (DAMPs), which is released by necrotic cells. However, extracellular histones remain unclear as DAMPs. In this study, we focused whether extracellular histones activate inflammasome (IL-1β release) in macrophage cell lines, which are ASC in the presence or absence. Therefore, histones induced IL-1βin macrophage cell-lines in the presence or absence ASC, suggesting that sepsis might enhance in extracellular histones.

  • Identification of genetic diseases of aged companion animals

    Grant number:26660242  2014.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Yamato Osamu, KAWASAKI Yasuaki, YABUKI Akira, MIURA Naoki, IWANAGA Tomoko

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    The objective of this study was to demonstrate that there are many adult-onset chronic genetic diseases in companion animals.
    The reference range of canine and feline lysosomal enzymes was established to diagnose several lysosomal diseases. Using high-risk screening, mucopolysaccharidosis was diagnosed in three cats. One case was categorized in type VI by measurement of enzyme activities, and a causative mutation was identified in this cat. Adult-onset neuronal ceroid lipofuscinosis was diagnosed in two dogs. Early-onset hypertrophic cardiomyopathy was diagnosed in a cat.
    Molecular epidemiological surveys were performed on feline mucopolysaccharidosis VI, feline pyruvate kinase deficiency, canine progressive retinal atrophy, and canine degenerative myelopathy. As a result, it was demonstrated that these diseases were present at a high frequency in the population of certain breeds, suggesting that these diseases are very important in veterinary clinics of companion animals.

  • The receptor and inhibitor of Nucleophosmin

    Grant number:26670793  2014.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Kawahara Ko-ichi, MARUYAMA Ikuro, MIURA Naoki, ITO Takashi

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    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    Nucleophosmin, which is a nucleoprotein, is major multifunctional protein involved in ribosomal biogenesis, centrosome duplication, cell cycle progression, apoptosis, and cell differentiation. Recently, nucleophosmin is released from endotoxin-stimulated macrophages and induces inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6, suggesting that nucleophosmin might be an alarmin. However, nucleophosmin's receptor and inhibitor remain unclear. In this study, we found the a nucleophosmin's receptor.

  • Identification of novel canine tumor related microRNA for elucidating the pathology and clinical relevance

    Grant number:25292180  2013.4 - 2016.3

    JSPA  KAKEN  Grant-in-Aid for Scientific Research (B)

    Miura Naoki, GOTOH AKINOBU, MARUYAMA IKUROU, KAWAHARA KOICHI, KAWAGUCHI HIROAKI, KINOSHITA ASUKA

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\15100000 ( Direct Cost: \15100000 、 Indirect Cost:\4530000 )

    The goal of this study is to identify the specific microRNA expression on the canine tumor. To archive this objective goal, small RNA sequence of canine hepatocellular carcinoma, mammary gland tumor, melanoma ware analyzed by RNBA-seq using the next-generation sequencer. In addition, selected microRNA expression ware investigated by real-time PCR in both tumor tissue, blood from canine patients, and cultured cell lines. In melanoma, miR-205 was down and miR-383 was up-regulated. In hepatocellular carcinoma and its cell lines, miR-1 and miR-122 is down regulation and their target mRNA (IGF1R and c-MET) is up-regulated. In mammary gland tumor, grovel miRNA expression was changed depend on malignancy. miR-21 is also up-regulated in blood of the metastatic mammary gland tumor.

  • Integrated molecular medicinal approach for rheumatic heart diseases in Central Asia.

    Grant number:25305032  2013.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    NAKAJIMA TOSHIHIRO, KAWAHARA Koichi, NISHI Junichiro, MIURA Naoki, Omurzakova Nazgul A.

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\17030000 ( Direct Cost: \13100000 、 Indirect Cost:\3930000 )

    Infectious diseases, called by bacteria - Group A Streptococcus and its complications, among which Rheumatic fever/Rheumatic Heart Disease are now in outbreak in many developing countries, especially in the Republics of Central Asia. This situation causes sudden death of young generations and socio-economical damages in the countries of Central Asia. We have been studing over 2000 subjects in the Kyrgyz Republic, as experimental country of the Central Asian region) by using a rapid antigen detection test (RADT) to detect Group A Streptococus.Then subjects with positive test results (apprx. 400-500) underwent through bacteriological culture on nutrient media smears from the throat with further growth of the bacteria streptococcus culture.As a result, we have found the biomass might be one of the risk factors for multiple bacterial infections via dysregulation of mucosal immunity.

  • 安全な牛乳の供給を目的とした牛乳中の標的microRNAの探索と検査法の確立

    2013.4 - 2015.3

    民間財団等  森永奉仕会研究助成 

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    Grant type:Competitive

    安全な牛乳の供給を目的とした牛乳中の標的microRNAの探索と検査法の確立

  • Identification of the microRNAs for new biomarkers in bovine mastitis

    Grant number:25660243  2013.4 - 2015.3

    JSPA  KAKEN  Grant-in-Aid for Challenging Exploratory Research

    MIURA Naoki, ANDO Takaaki, KITAHARA Go

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    Bovine mastitis is major concern in livestock animal. The primary aim of this study was to identify alternatively expressed miRNAs as biomarker in mastitis milk compare to normal milk.
    In this study, total 9 microRNAs were identify as alternatively expressed microRNA in mastitis. Seven of them were increased and two of them were decreased. There is inflammation associated microRNAs which increased in mastitis milk. These microRNAs may be the new target miRNAs as biomarkers of bovine mastitis milk.

  • Development of Microminipig model of atherosclerosis for medical device development

    Grant number:25450426  2013 - 2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Kawaguchi Hiroaki, IZUMI Yasukatsu

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\5200000 ( Direct Cost: \4000000 、 Indirect Cost:\1200000 )

    We established a model of atherosclerosis in the Microminipig by giving animals a high fat and high cholesterol diet for 8 weeks. The aim of this study is to induce atherosclerosis which can be confirmed by a clinical imaging test for short period using the previous our model. This study added angiotensin II for 2 weeks or NOS inhibitor for 8 weeks to the above diet control. The addition of angiotensin II and NOS could induce accelerated atherosclerotic lesions of systemic aorta and arteries for while the atherosclerotic lesions (ex. intima thickening) were not recognized by carotid artery echo. Model improvement or consideration of evaluation method (ex. CAVI: Cardio Ankle Vascular Index) will be needed in the future.

  • マイクロミニブタ動脈硬化モデルでの炎症性サイトカインHMGB1と血栓傾向の関連

    2012.4 - 2014.3

    民間財団等  先進医薬研究振興財団第31回 血液医学分野 一般研究助成金 

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    Grant type:Competitive

    マイクロミニブタ動脈硬化モデルでの炎症性サイトカインHMGB1と血栓傾向の関連

  • 乳房炎の早期診断マーカーとしてのmicroRNA

    2012.4 - 2013.3

    民間財団等  公益財団法人 サンケイ科学振興財団研究助成金 

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    Grant type:Competitive

    乳房炎の早期診断マーカーとしてのmicroRNA

  • MicroRNA expression in the canine tumor

    Grant number:22780283  2010.4 - 2012.3

    JSPA  KAKEN  Grant-in-Aid for Young Scientists (B)

    MIURA Naoki

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    A few novel microRNAs, which was up-or down-regulated in either mammary gland tumor or melanoma, were identified by the canine micro RNA microarray. The differential expression of these microRNAs was confirmed by quantitative RT-PCR. We also found that miR-21 and miR-92a had been significantly higher existing in the plasma from dog with mammary gland tumor compared to clinically healthy dog.

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Media Coverage

  • 牛の精子・受精卵 新保存技術 Newspaper, magazine

    朝日新聞  2020.1

  • 受胎率向上へ精液・受精卵の新凍結法を開発 Newspaper, magazine

    日刊酪農乳業速報  2019.12

  • 牛の人工授精‐受胎率向上へ 新凍結保護剤 Newspaper, magazine

    南日本新聞  2019.12

Academic Activities

  • 評議員(日本獣医学会)

    日本獣医学会  2021

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  • 理事(日本放射線教育研究会)

    日本放射線教育研究会  2020.9

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  • Associate Editor (Frontier In Veterinary Science, Oncology in Veterinary Medicine) International contribution

    Role(s): Review, evaluation

    2022.10

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  • Review Editor (Frontier In Veterinary Science, in Veterinary Experimental and Diagnostic Pathology) International contribution

    Role(s): Review, evaluation

    2021

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  • Invited Editor (Journal of Veterinary Medical and One Health Research) International contribution

    Role(s): Review, evaluation

    2021

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  • Associate Editorial Bord (Veterinary Record Case Reports) International contribution

    Role(s): Review, evaluation

    2016

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    Type:Scientific advice/Review 

  • Scientific Reports (査読)

    Role(s): Peer review

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  • PLoS One (査読)

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  • Australian veterinary journal (査読)

    Role(s): Peer review

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  • Oncology Reports (査読)

    Role(s): Peer review

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  • Oncology Letter (査読)

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  • Molecular Medical Reports (査読)

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  • Journal of the Science of Food and Agriculture (査読)

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  • Journal Artherosclerosis and Thrombosis(査読)

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  • International Journal Molecular Medicine (査読)

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  • GENE (査読)

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  • European Joournal Pharmacology  (査読)

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  • Journal of Veterinary Medical Science (査読)

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  • Research in Veterinary Science (査読)

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  • Veterinary Research Communications (査読)

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  • Veterinary Research (査読)

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  • 日本獣医師会雑誌(査読)

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  • Philippine Journal of Veterinary Medicine (査読)

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  • BMC Veterinary Research (査読)

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  • Frontier In Veterinary Science (査読)

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  • Experimental Animals (査読)

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  • Journal of Veterinary Medical Research (査読)

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  • Veterinary and Comparative Oncology (査読)

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  • Animal Science Journal (査読)

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  • Annals of Translational Medicine (査読)

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  • Animals (査読)

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