2023/12/19 更新

写真a

コオリヤマ チハヤ
郡山 千早
KORIYAMA Chihaya
所属
医歯学域医学系 医歯学総合研究科 健康科学専攻 人間環境学講座 教授
医歯学域医学系 医学部  
職名
教授

学位

  • 公衆衛生修士(Master of Public Health) ( 1998年6月   ハーバード大学公衆衛生大学院(アメリカ合衆国) )

  • 博士(医学) ( 1995年3月   鹿児島大学 )

研究キーワード

  • こども

  • 遺伝素因

  • ウイルス

  • 喫煙

  • 疫学

  • がん

研究分野

  • ライフサイエンス / 医療管理学、医療系社会学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含む

経歴

  • 鹿児島大学   医歯学域医学系 医歯学総合研究科 健康科学専攻 人間環境学講座   教授

    2017年4月 - 現在

  • 鹿児島大学   医歯学域医学系 医歯学総合研究科 健康科学専攻 人間環境学講座   准教授

    2003年4月 - 2017年3月

  • 鹿児島大学    

    1995年4月 - 現在

所属学協会

  • 日本がん疫学・分子疫学研究会

    2015年10月 - 現在

  • 日本医学教育学会

    2015年10月 - 現在

  • 日本癌学会

    2015年10月 - 現在

  • 日本ウイルス学会

    2015年10月 - 現在

  • 日本疫学会

    2015年10月 - 現在

  • 日本公衆衛生学会

    2015年10月 - 現在

▼全件表示

取得資格

  • 社会医学系専門医

 

論文

  • Nakamura M., Tatsuta N., Murata K., Nakai K., Iwata T., Otobe T., Sakamoto M., Yamamoto M., Itatani M., Miura Y., Koriyama C. .  Neurodevelopmental associations of prenatal and postnatal methylmercury exposure among first-grade children in the Kinan region, Japan .    235   116688   2023年10月査読

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    担当区分:最終著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.envres.2023.116688

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  • Muniroh M., Bakri S., Gumay A.R., Dewantiningrum J., Mulyono M., Hardian H., Yamamoto M., Koriyama C. .  The First Exposure Assessment of Mercury Levels in Hair among Pregnant Women and Its Effects on Birth Weight and Length in Semarang, Central Java, Indonesia .  International Journal of Environmental Research and Public Health19 ( 17 )   2022年9月査読 国際共著

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    担当区分:最終著者   記述言語:英語  

    DOI: 10.3390/ijerph191710684

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  • Oze I., Ito H., Kasugai Y., Yamaji T., Kijima Y., Ugai T., Kasuga Y., Ouellette T.K., Taniyama Y., Koyanagi Y.N., Imoto I., Tsugane S., Koriyama C., Iwasaki M., Matsuo K. .  A personal breast cancer risk stratification model using common variants and environmental risk factors in japanese females .  Cancers13 ( 15 )   2021年8月査読 国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cancers  

    Personalized approaches to prevention based on genetic risk models have been anticipated, and many models for the prediction of individual breast cancer risk have been developed. However, few studies have evaluated personalized risk using both genetic and environmental factors. We developed a risk model using genetic and environmental risk factors using 1319 breast cancer cases and 2094 controls from three case–control studies in Japan. Risk groups were defined based on the number of risk alleles for 14 breast cancer susceptibility loci, namely low (0–10 alleles), moderate (11–16) and high (17+). Environmental risk factors were collected using a self-administered questionnaire and implemented with harmonization. Odds ratio (OR) and C-statistics, calculated using a logistic regression model, were used to evaluate breast cancer susceptibility and model performance. Respective breast cancer ORs in the moderate-and high-risk groups were 1.69 (95% confidence interval, 1.39–2.04) and 3.27 (2.46–4.34) compared with the low-risk group. The C-statistic for the environmental model of 0.616 (0.596–0.636) was significantly improved by combination with the genetic model, to 0.659 (0.640–0.678). This combined genetic and environmental risk model may be suitable for the stratification of individuals by breast cancer risk. New approaches to breast cancer prevention using the model are warranted.

    DOI: 10.3390/cancers13153796

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  • David J. .  Inorganic mercury-induced mip-2 expression is suppresseby n-acetyl-l-cysteine in raw264.7 macrophages .  Biomedical Reports12 ( 2 ) 39 - 45   2020年2月国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Biomedical Reports  

    DOI: 10.3892/br.2019.1263

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  • Tsuji M, Koriyama C, Ishihara Y, Yamamoto M, Yamamoto-Hanada K, Kanatani K et al. .  Associations between metal levels in whole blood and IgE concentrations in pregnant women based on data from the Japan Environment and Children’s Study .  Journal of Epidemiology   2019年1月招待 査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2188/jea.JE20180098

  • Kodama S., Uwatoko F., Koriyama C. .  Relationship between changes in the public health nurses’ workforce and the empirical Bayes estimates of standardized mortality ratio: a longitudinal ecological study of municipalities in Japan .  BMC Health Services Research23 ( 1 ) 266   2023年12月

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    担当区分:最終著者   記述言語:日本語   出版者・発行元:BMC Health Services Research  

    Background: The role of public health nurses (PHNs) in the community is expected to become increasingly important, along with the promotion of a comprehensive community care system. However, a comprehensive study of all municipalities is yet to be undertaken, and the relationship between the workforce of PHNs and health indicators is yet to be clarified. This study examined the effect of workforce change among PHNs, one of the structural indicators of PHNs’ activities regarding changes in the empirical Bayes estimate of standardized mortality ratios (EBSMRs). Methods: An ecological study was conducted using municipality-level aggregate data. The data used were publicly available Japanese government statistics. The first-difference model of panel data analysis was used to examine the relationship between changes in EBSMR and changes in the number of PHNs per 100,000 population from 2010 to 2015, adjusting for the effects of population and other healthcare resources, including the number of physicians, medical clinics, general hospitals, and welfare facilities. The variation by the 47 prefectures was added to the linear model as a random effect. We also performed a sensitivity analysis using the full Bayesian inference using the Besag-York-Mollie model. Results: For males, EBSMRs for all causes and malignant neoplasms significantly decreased with an increase in the number of PHNs per population (coefficients: -1.00 and -0.89, p values: 0.008 and 0.043, respectively). For females, although all EBSMRs except malignant neoplasms showed decreased tendencies due to the increase in the number of PHNs per population, none of them were significant. The full Bayesian inference confirmed these associations. Conclusions: An increase in the number of PHNs per population was significantly associated with a greater reduction in deaths from all causes and malignant neoplasms in males. The results of the full Bayesian inference also suggest that the workforce of PHNs may be related to changes in standardized mortality ratios for deaths from all causes in females.

    DOI: 10.1186/s12913-023-09273-2

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  • Kurasawa S., Imaizumi T., Maruyama S., Tanaka K., Kubo Y., Nagayoshi M., Ikezaki H., Suzuki S., Koyama T., Koriyama C., Kadota A., Katsuura-Kamano S., Kuriki K., Wakai K., Matsuo K. .  Association of kidney function with cancer incidence and its influence on cancer risk of smoking: The Japan Multi-Institutional Collaborative Cohort Study .  International Journal of Cancer153 ( 4 ) 732 - 741   2023年8月

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    記述言語:日本語   出版者・発行元:International Journal of Cancer  

    The association between kidney function and cancer incidence is inconsistent among previous reports, and data on the Japanese population are lacking. It is unknown whether kidney function modifies the cancer risk of other factors. We aimed to evaluate the association of estimated glomerular filtration rate (eGFR) with cancer incidence and mortality in 55 242 participants (median age, 57 years; 55% women) from the Japan Multi-Institutional Collaborative Cohort Study. We also investigated differences in cancer risk factors between individuals with and without kidney dysfunction. During a median 9.3-year follow-up period, 4278 (7.7%) subjects developed cancer. Moderately low and high eGFRs were associated with higher cancer incidence; compared with eGFR of 60-74 ml/min/1.73 m2, the adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) for eGFRs of ≥90, 75-89, 45-59, 30-44 and 10-29 ml/min/1.73 m2 were 1.18 (1.07-1.29), 1.09 (1.01-1.17), 0.93 (0.83-1.04), 1.36 (1.00-1.84) and 1.12 (0.55-2.26), respectively. High eGFR was associated with higher cancer mortality, while low eGFR was not; the adjusted subdistribution HRs (95% CIs) for eGFRs of ≥90 and 75-89 ml/min/1.73 m2 were 1.58 (1.29-1.94) and 1.27 (1.08-1.50), respectively. Subgroup analyses of participants with eGFRs ≥60 and <60 ml/min/1.73 m2 revealed elevated cancer risks of smoking and family history of cancer in those with eGFR <60 ml/min/1.73 m2, with significant interactions. Our findings suggest that the relationship between eGFR and cancer incidence was U-shaped. Only high eGFR was associated with cancer mortality. Kidney dysfunction enhanced cancer risk from smoking.

    DOI: 10.1002/ijc.34554

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  • Yoshimitsu K., Mori S., Tanabe K., Wada M., Hamada Y., Yasudome R., Kurahara H., Arigami T., Sasaki K., Koriyama C., Higashi M., Nakajo A., Ohtsuka T. .  Transanal Total Mesorectal Excision Considering the Embryology Along the Fascia in Rectal Cancer Patients .  Anticancer Research43 ( 8 ) 3597 - 3605   2023年8月

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    記述言語:日本語   出版者・発行元:Anticancer Research  

    Background/Aim: Transanal total mesorectal excision (TaTME) remains a challenging technique for rectal dissection. This study aimed to evaluate the clinical and oncological outcomes of TaTME, compared to those of the laparoscopic TME (LaTME) in rectal cancer. Patients and Methods: Using propensity score-matched analyses, we analyzed retrospective data from 134 consecutive patients with rectal cancer who underwent TaTME or LaTME from January 2011 to June 2020 in our hospital. Clinical and oncological outcomes were evaluated. The primary endpoint was the 2-year local recurrence rate. Results: Before data analysis, significant group-dependent differences were observed only in the tumor height (p<0.01). After analysis, preoperative patient demographics were similar between the TaTME and LaTME groups. The operative time was significantly shorter in the TaTME group (p=0.02), and the rates of hand-sewn anastomosis and protective loop ileostomy were significantly higher (p<0.01). The TaTME group showed a null conversion to open surgery compared to the LaTME group (5.9%). The postoperative complications, including anastomotic leak, were comparable between the two groups. However, the rate of Clavien-Dindo grade III tended to be lower in the TaTME group (p=0.07). There were no statistically significant differences in terms of pathological findings, and the 2-year local recurrence rate was similar between the two groups (both 5.9%). Conclusion: TaTME based on embryology along the fascia is feasible and seems a safe alternative to LaTME in selected patients with rectal cancer when considering the conversion rate and the operative time.

    DOI: 10.21873/anticanres.16539

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  • Tamura T., Wakai K., Kato Y., Tamada Y., Kubo Y., Okada R., Nagayoshi M., Hishida A., Imaeda N., Goto C., Ikezaki H., Otonari J., Hara M., Tanaka K., Nakamura Y., Kusakabe M., Ibusuki R., Koriyama C., Oze I., Ito H., Suzuki S., Nakagawa-Senda H., Ozaki E., Matsui D., Kuriki K., Kondo K., Takashima N., Watanabe T., Katsuura-Kamano S., Matsuo K. .  Dietary Carbohydrate and Fat Intakes and Risk of Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study .  Journal of Nutrition153 ( 8 ) 2352 - 2368   2023年8月

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    記述言語:日本語   出版者・発行元:Journal of Nutrition  

    Background: Previous cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality. Objectives: We examined long-term associations of carbohydrate and fat intakes with mortality. Methods: In this cohort study, 34,893 men and 46,440 women aged 35–69 y (mean body mass index of 23.7 and 22.2 kg/m2, respectively) were followed up from the baseline survey (2004–2014) to the end of 2017 or 2018. Intakes of carbohydrate, fat, and total energy were estimated using a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for all-cause and cause-specific mortality according to percentage of energy intakes of carbohydrate and fat. Results: During a mean 8.9-y follow-up, we identified 2783 deaths (1838 men and 945 women). Compared with men who consumed 50% to <55% of energy from carbohydrate, those who consumed <40% carbohydrate energy experienced a significantly higher risk of all-cause mortality (the multivariable-adjusted HR: 1.59; 95% CI: 1.19–2.12; P-trend = 0.002). Among women with 5 y or longer of follow-up, women with high-carbohydrate intake recorded a higher risk of all-cause mortality; the multivariable-adjusted HR (95% CI) was 1.71 (0.93–3.13) for ≥65% of energy from carbohydrate compared with that for 50% to <55% (P-trend = 0.005). Men with high fat intake had a higher risk of cancer-related mortality; the multivariable-adjusted HR (95% CI) for ≥35% was 1.79 (1.11–2.90) compared with that for 20% to <25%. Fat intake was marginally inversely associated with risk of all-cause and cancer-related mortality in women (P-trend = 0.054 and 0.058, respectively). Conclusions: An unfavorable association with mortality is observed for low-carbohydrate intake in men and for high-carbohydrate intake in women. High fat intake can be associated with a lower mortality risk in women among Japanese adults with a relatively high-carbohydrate intake.

    DOI: 10.1016/j.tjnut.2023.05.027

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  • Tsuji Mayumi, Hori Hajime, Koriyama Chihaya, Tanaka Rie, Isse Toyohi, Ishihara Yasuhiro, Ishizuka Tsunetoshi, Hasegawa Wataru, Goto Motohide, Yatera Kazuhiro, Kunugita Naoki, Kuwamura Mami, Sakuragi Toshihide, Yasumura Yoshiko, Yamamoto Megumi, Ueno Susumu .  The effect of mask fit test on the association between the concentration of metals in biological samples and the results of time-weighted average personal exposure: A study on Japanese male welders(タイトル和訳中) .  Journal of Occupational Health65 ( 1 ) 1 of 9 - 9 of 9   2023年6月

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    記述言語:英語   出版者・発行元:(公社)日本産業衛生学会  

  • Kuroda Y., Goto A., Koriyama C., Suzuki K. .  Association of health literacy with anxiety about COVID-19 under an infectious disease pandemic in Japan .  Health Promotion International38 ( 2 )   2023年4月

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    記述言語:日本語   出版者・発行元:Health Promotion International  

    We quantitatively analysed the relationship of health literacy with both anxiety about the COVID-19 outbreak and free-Text qualitative data. A questionnaire was mailed to 5450 citizens aged 16-89 years in four prefectures between late April and May 2020. It gauged the level of anxiety about COVID-19, assessed health literacy (HL) on both critical and communicative HL subscales, and invited free-Text responses. We compared anxiety levels in three groups of both HL subscales. Text-mining analyses were also conducted among the three HL groups. Two-Thirds of respondents reported anxiety about COVID-19, and 42% of them also reported fear. The level of communicative HL was negatively associated with no or low anxiety (p < 0.01), and the same association was observed for critical HL (p < 0.01). Free-Text analysis identified 11 categories related to concerns about COVID-19: response of the national government, appreciation of health care practitioners, early convergence, vaccine development, fear of infection, invisible, a school for children, everyday life, information-related issue, novel coronavirus and self-quarantine. Words that were characteristic of the high-HL group were 'information', 'going out', 'vaccines' and 'government'. This survey reveals high public anxiety under COVID-19, and while anxiety is associated with HL levels, people with higher HL may make more prudent and healthier decisions. In situations of uncertainty, different approaches to alleviate anxiety depending on HL are warranted, providing new insights and contributing to public health measures during the outbreaks.

    DOI: 10.1093/heapro/daac200

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  • Sakashita Takuya, Nakamura Yasuyuki, Sutoh Yoichi, Shimizu Atsushi, Hachiya Tsuyoshi, Otsuka-Yamasaki Yayoi, Takashima Naoyuki, Kadota Aya, Miura Katsuyuki, Kita Yoshikuni, Ikezaki Hiroaki, Otonari Jun, Tanaka Keitaro, Shimanoe Chisato, Koyama Teruhide, Watanabe Isao, Suzuki Sadao, Nakagawa-Senda Hiroko, Hishida Asahi, Tamura Takashi, Kato Yasufumi, Okada Rieko, Kuriki Kiyonori, Katsuura-Kamano Sakurako, Watanabe Takeshi, Tanoue Shiroh, Koriyama Chihaya, Oze Isao, Koyanagi Yuriko N., Nakamura Yohko, Kusakabe Miho, Nakatochi Masahiro, Momozawa Yukihide, Wakai Kenji, Matsuo Keitaro .  Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population(タイトル和訳中) .  Diabetology International14 ( 2 ) 188 - 198   2023年4月

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    記述言語:英語   出版者・発行元:シュプリンガー・ジャパン(株)  

  • Watanabe T., Arisawa K., Nguyen T.V., Ishizu M., Katsuura-Kamano S., Hishida A., Tamura T., Kato Y., Okada R., Ibusuki R., Koriyama C., Suzuki S., Otani T., Koyama T., Tomida S., Kuriki K., Takashima N., Miyagawa N., Wakai K., Matsuo K. .  Coffee and metabolic phenotypes: A cross-sectional analysis of the Japan multi-institutional collaborative cohort (J-MICC) study .  Nutrition, Metabolism and Cardiovascular Diseases33 ( 3 ) 620 - 630   2023年3月

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    記述言語:日本語   出版者・発行元:Nutrition, Metabolism and Cardiovascular Diseases  

    Background and aims: To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population. Methods and results: We analyzed the data of 26,363 subjects (aged 35–69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m2; obesity: BMI ≥25 kg/m2) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI. In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76–0.90) and obese subjects (OR 0.83, 95% CI 0.69–0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not. Conclusion: The present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults.

    DOI: 10.1016/j.numecd.2022.12.019

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  • Tsuji Mayumi, Koriyama Chihaya, Ishihara Yasuhiro, Isse Toyohi, Ishizuka Tsunetoshi, Hasegawa Wataru, Goto Motohide, Tanaka Rie, Kakiuchi Noriaki, Hori Hajime, Yatera Kazuhiro, Kunugita Naoki, Yamamoto Megumi, Sakuragi Toshihide, Yasumura Yoshiko, Kono Maori, Kuwamura Mami, Kitagawa Kyoko, Ueno Susumu .  日本人男性の溶接工と非溶接工における溶接ヒューム曝露と神経機能との関連(Associations between welding fume exposure and neurological function in Japanese male welders and non-welders) .  Journal of Occupational Health65 ( 1 ) 1 of 11 - 11 of 11   2023年2月

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    記述言語:英語   出版者・発行元:(公社)日本産業衛生学会  

    日本人男性の溶接工と非溶接工にみられるマンガン(Mn)曝露と神経機能との関連を検討した。同一の工場に勤務する溶接工94名(平均41.1歳)と非溶接工95名(平均40.2歳)を対象に血液サンプルと尿サンプルを採取してMn濃度を測定し、神経機能との関係を評価した。また、溶接工のみ個人サンプラーを用いて呼吸大気領域の採取を行った。尿中カドミウム(Cd)、血中Mn、尿中Mn、尿中クロム(Cr)、血中鉛(Pb)はいずれも溶接工の方が非溶接工より高く、各金属濃度が検出限界値未満であった被験者比率は血中Cdが89%、尿中Cdが58%、血中ニッケル(Ni)が79%などであった。多変量ロジスティック回帰分析では、握力、指タッピングと血中Mnとの間に有意な関係はみられなかったが、血中Mn高値群では作業記憶指数(WMI)低値のオッズ比が有意に高く、特に溶接工でこの関連が顕著であった。尿中Cr、血中PbとWMIスコアとの間に有意な関連はなかった。個人サンプラーを用いた検討では、血中Mnが高値であった溶接工において呼吸性粉塵とマンガン濃度が高値を示していた。

  • Tsuji M., Hori H., Koriyama C., Tanaka R., Isse T., Ishihara Y., Ishizuka T., Hasegawa W., Goto M., Yatera K., Kunugita N., Kuwamura M., Sakuragi T., Yasumura Y., Yamamoto M., Ueno S. .  The effect of mask fit test on the association between the concentration of metals in biological samples and the results of time-weighted average personal exposure: A study on Japanese male welders .    65 ( 1 ) n/a   2023年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:公益社団法人 日本産業衛生学会  

    OBJECTIVES: The mask fit test confirms whether the wearing condition of the wearer's face and the facepiece of the respirators are used appropriately. This study aimed to examine whether the results of the mask fit test affect the association between the concentration of metals related to welding fumes in biological samples and the results of time-weighted average (TWA) personal exposures. METHODS: A total of 94 male welders were recruited. Blood and urine samples were obtained from all participants to measure the metal exposure levels. Using personal exposure measurements, the 8-h TWA (8 h-TWA) of respirable dust, TWA of respirable Mn, and 8-h TWA of respirable Mn were calculated. The mask fit test was performed using the quantitative method specified in the Japanese Industrial Standard T8150:2021. RESULTS: Fifty-four participants (57%) passed the mask fit test. Only in the Fail group of the mask fit test, it was observed that blood Mn concentrations be positively associated with the results of TWA personal exposure after adjusting for multivariate factors (8-h TWA of respirable dust; coefficient, 0.066; standard error (SE), 0.028; P = 0.018, TWA of respirable Mn: coefficient, 0.048; SE, 0.020; P = 0.019, 8 h-TWA of respirable Mn: coefficient, 0.041; SE, 0.020; P = 0.041). CONCLUSIONS: The results clarify that welders with high concentrations of welding fumes in their breathing air zone are exposed to dust and Mn if there is leaking air owing to the lack of fitness between respirators and the wearer's face when using human samples in Japan.

    DOI: 10.1002/1348-9585.12399

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  • Tsuji M., Koriyama C., Ishihara Y., Isse T., Ishizuka T., Hasegawa W., Goto M., Tanaka R., Kakiuchi N., Hori H., Yatera K., Kunugita N., Yamamoto M., Sakuragi T., Yasumura Y., Kono M., Kuwamura M., Kitagawa K., Ueno S. .  Associations between welding fume exposure and neurological function in Japanese male welders and non-welders .    65 ( 1 ) n/a   2023年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:公益社団法人 日本産業衛生学会  

    OBJECTIVES: There are some studies reporting the association between (manganese [Mn]) exposure to welding fume and neurological dysfunction. This study examined the relationship between Mn exposure and neurological behavior in Japanese male welders and non-welders using biological samples, which to date has not been assessed in Japan. METHODS: A total of 94 male welders and 95 male non-welders who worked in the same factories were recruited. The blood and urine samples were obtained from all the participants to measure Mn exposure levels. Neurological function tests were also conducted with all participants. The sampling of the breathing air zone using a personal sampler was measured for welders only. RESULTS: The odds ratios (ORs) for the Working Memory Index (WMI) scores were significantly higher among all participants in the low blood Mn concentration group than those in the high blood Mn concentration group (OR, 2.77; 95% confidence interval [CI], 1.24, 6.19; P = .013). The association of WMI scores and blood Mn levels in welders had the highest OR (OR, 3.73; 95% CI, 1.04, 13.38; P = .043). Although not statistically significant, a mild relationship between WMI scores and blood Mn levels was observed in non-welders (OR, 2.09; 95% CI, 0.63, 6.94; P = .227). CONCLUSIONS: The results revealed a significant positive relationship between blood Mn and neurological dysfunction in welders. Furthermore, non-welders at the same factories may be secondarily exposed to welding fumes. Further research is needed to clarify this possibility.

    DOI: 10.1002/1348-9585.12393

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  • Sakashita T., Nakamura Y., Sutoh Y., Shimizu A., Hachiya T., Otsuka-Yamasaki Y., Takashima N., Kadota A., Miura K., Kita Y., Ikezaki H., Otonari J., Tanaka K., Shimanoe C., Koyama T., Watanabe I., Suzuki S., Nakagawa-Senda H., Hishida A., Tamura T., Kato Y., Okada R., Kuriki K., Katsuura-Kamano S., Watanabe T., Tanoue S., Koriyama C., Oze I., Koyanagi Y.N., Nakamura Y., Kusakabe M., Nakatochi M., Momozawa Y., Wakai K., Matsuo K. .  Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population .  Diabetology International14 ( 2 ) 188 - 198   2023年

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    記述言語:日本語   出版者・発行元:Diabetology International  

    Aims: Hemoglobin A1c (HbA1c) levels are widely employed to diagnose diabetes. However, estimates of the heritability of HbA1c and glucose levels are different. Therefore, we explored HbA1c- and blood glucose-associated loci in a non-diabetic Japanese population. Methods: We conducted a two-stage genome-wide association study (GWAS) on variants associated with HbA1c and blood glucose levels in a Japanese population. In the initial stage, data of 4911 participants of the Japan Multi-Institutional Collaborative Cohort (J-MICC) were subjected to discovery analysis. In the second stage, two datasets from the Tohoku Medical Megabank project, with 8175 and 40,519 participants, were used for the replication study. Association of the imputed variants with HbA1c and blood glucose levels was determined via linear regression analyses adjusted for age, sex, body mass index (BMI), smoking, and genetic principal components (PC1–PC10). Moreover, we performed a BMI-stratified GWAS on HbA1c levels in the J-MICC. The discovery analysis and BMI-stratified GWAS results were validated with re-analyses of normalized HbA1c levels adjusted for site in addition to the above, and blood glucose adjusted for fasting time as an additional covariate. Results: Genetic variants associated with HbA1c levels were identified in KCNQ1 and TMC6. None of the genetic variants associated with blood glucose levels in the discovery analysis were replicated. Association of rs2299620 in KCNQ1 with HbA1c levels showed heterogeneity between individuals with BMI ≥ 25 kg/m2 and BMI < 25 kg/m2. Conclusions: The variant rs2299620 in KCNQ1 might affect HbA1c levels differentially based on BMI grouping in the Japanese population.

    DOI: 10.1007/s13340-023-00618-0

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  • Kitaoka K, Miura K, Takashima N, Kadota A, Harada A, Nakamura Y, Kita Y, Yano Y, Tamura T, Nagayoshi M, Okada R, Kubo Y, Suzuki S, Nishiyama T, Tanoue S, Koriyama C, Kuriki K, Arisawa K, Katsuura-Kamano S, Nishida Y, Shimanoe C, Ozaki E, Matsui D, Ikezaki H, Otonari J, Oze I, Koyanagi YN, Nakamura Y, Kusakabe M, Wakai K, Matsuo K, J-MICC Research Group .  Association between Dietary Patterns and Serum Low Density Lipoprotein Cholesterol in Japanese Women and Men: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. .  Journal of Atherosclerosis and Thrombosisadvpub ( 0 ) 1427 - 1447   2023年

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    記述言語:英語   出版者・発行元:一般社団法人 日本動脈硬化学会  

    AIMS: The association between dietary patterns and serum low density lipoprotein (LDL) cholesterol would be changing in recent dietary habits in Japan. We investigated the relationship between dietary patterns and serum LDL cholesterol in a large general population. METHODS: From the baseline survey of Japan Multi-Institutional Collaborative Cohort Study between 2005 and 2013, 27,237 participants (13,994 were women) aged 35-69 years were cross-sectionally analyzed. Using a semi-quantitative food frequency questionnaire, five major sex-specific dietary patterns were identified using factor analysis. We assessed serum LDL cholesterol by quintiles of dietary pattern factor score. RESULTS: We identified dietary patterns; "vegetable rich pattern" , "meat and fried food rich pattern" and "high bread and low rice pattern" in women and men; "fish and shellfish rich pattern" and "high confectioneries and low alcohol pattern" in men; "healthy Japanese diet pattern" and "high alcohol and low rice pattern" in women. Serum LDL cholesterol in men was associated with "high bread and low rice pattern" score (Q5 was 4.2 mg/dL higher than Q1, p for trend <0.001) and "high confectioneries and low alcohol pattern" scores (Q5 was 9.5 mg/dL higher than Q1, p for trend <0.001). In women, serum LDL cholesterol was associated with "high bread and low rice pattern" score (Q5 was 7.1 mg/dL higher than Q1, p for trend <0.001). CONCLUSION: Some recent dietary patterns in Japan were associated with serum LDL cholesterol. Serum LDL cholesterol was associated with high bread and low rice pattern in both sex, and high confectioneries and low alcohol pattern in men.

    DOI: 10.5551/jat.63675

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  • Sogawa R., Shimanoe C., Tanaka K., Hara M., Nishida Y., Furukawa T., Nagayoshi M., Hishida A., Kubo Y., Kato Y., Oze I., Ito H., Nakamura Y., Kusakabe M., Tanoue S., Koriyama C., Suzuki S., Otani T., Matsui D., Watanabe I., Kuriki K., Takashima N., Kadota A., Watanabe T., Arisawa K., Ikezaki H., Otonari J., Wakai K., Matsuo K. .  Sex- and age-specific all-cause mortality in insomnia with hypnotics: Findings from Japan multi-institutional Collaborative Cohort Study .  Sleep Medicine100   410 - 418   2022年12月

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    記述言語:日本語   出版者・発行元:Sleep Medicine  

    Objective: Findings on the increased mortality risk in individuals with insomnia are inconsistent across studies. Rather than improving insomnia by sleep control, hypnotic use may be one factor in the increased risk of death; however, the effects of hypnotics on mortality remains unclear. This study aimed to examine the association between all-cause mortality and hypnotic use in a large sample, while adjusting for the effects of comorbidities. Methods: Overall, 92,527 individuals aged 35–69 years were followed up for mortality in the Japan Multi-Institutional Collaborative Cohort Study. Regular use of hypnotics was assessed using a self-administered questionnaire. Since cancer history carries a substantial risk of death and is associated with the treatment of insomnia with hypnotics, participants with a cancer history were excluded. The hazard ratio (HR) and 95% confidence interval (CI) for all-cause mortality related to hypnotic use were estimated using a Cox proportional hazard model with adjustments for covariates including sleeping hours and comorbidities (body mass index, ischemic heart disease, stroke, and diabetes). Results: During the follow-up (mean, 8.4 ± 2.5 years), 1,492 mortalities were recorded, and the prevalence of taking hypnotics was 4.2%. Hypnotic use was associated with significantly greater risk of all-cause mortality, even after adjustment for the covariates (HR, 1.32; 95% CI, 1.07–1.63). The association between hypnotic use and all-cause mortality was robust in males (HR, 1.51; 95% CI, 1.15–1.96), and participants aged <60 years (HR, 1.75; 95% CI, 1.21–2.54). Conclusions: Our study revealed sex-age specific associations between hypnotic use and all-cause mortality.

    DOI: 10.1016/j.sleep.2022.09.020

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  • 若山 怜, 後藤 あや, 郡山 千早, 鈴木 孝太 .  子どもと同居する親の,喫煙と感染症に対する予防行動の関連 .  日本小児禁煙研究会雑誌12 ( 2 ) 42 - 45   2022年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本小児禁煙研究会  

    子どもと同居している20代から40代の成人について、喫煙状況と感染症に対する予防行動との関連について検討した。2020年4月24日~5月8日の間に東京都、愛知県、福島県、鹿児島県に在住する16歳から89歳までの一般市民5450人を対象に、「新型コロナウイルス感染症(COVID-19)に関する一般市民の意識や行動変容に関する調査」として郵送による質問紙調査を実施した。3554人(回収率65.2%)から回答を得て、このうち子どもと同居していると回答した20代から40代の男女845人を解析対象とした。喫煙者の割合は男性が33.4%、女性が10.8%であった。喫煙者における予防行動の維持・改善のオッズ比(OR)は、手洗いについて男性ではOR 1.0、女性ではOR 0.3、マスクの着用頻度について男性ではOR 0.6、女性ではOR 0.9であった。インフルエンザワクチンの接種については男性ではOR 0.5、女性ではOR 0.5であった。子どもと同居する20代から40代の成人において、喫煙状況と感染症予防行動に関連がある可能性が示唆された。

  • Tashiro Y., Matsuura E., Sagara Y., Nozuma S., Kodama D., Tanaka M., Koriyama C., Kubota R., Takashima H. .  High Prevalence of HTLV-1 Carriers among the Elderly Population in Kagoshima, a Highly Endemic Area in Japan .  AIDS Research and Human Retroviruses38 ( 5 ) 363 - 369   2022年5月

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    記述言語:日本語   出版者・発行元:AIDS Research and Human Retroviruses  

    Japan is one of the world's highly endemic areas for human T cell leukemia virus type 1 (HTLV-1), and it is known that the infection rate of HTLV-1 increases with age. The infection rate among the elderly has been estimated based on data from blood donors under the age of 65, and the actual number and rate of infection among the elderly are unknown. Data of 26,090 preoperative HTLV-1 screening tests conducted at Kagoshima University Hospital from 2001 to 2020, including 2726 HTLV-1-positive patients, were used for calculating the decadal infection rates for the year of birth. Estimated infection rates by birth year and demographic tables were used to estimate the current number of infected people in Kagoshima. The estimated total numbers of people infected with HTLV-1 in Kagoshima prefecture were 139,436 in 2005 and 80,975 in 2019. The infection rate increased with age for both men and women, reaching 17.3% for women born before the 1920s. Next, we tried to clarify whether the increase in infection rates with age was due to post-school age infections. The age of birth with the greatest increase in infection rate after 10 years was women born in the 1970s, and the increase in infection rate was only 0.98%, which is not a statistically significant increase. The number of infected people in Kagoshima was >80,000 in 2019. No data were available in this study to point to the involvement of horizontal transmission after school age in the high infection rate among the elderly. The high infection rate among the elderly is thought to have been high even when they were infants.

    DOI: 10.1089/aid.2021.0164

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  • Kanouchi H., Yamashita M., Kaimoto K., Kuwabara A., Kawakami Y., Takenaka S., Koriyama C., Kuwahata S., Takenaka T., Akasaki Y., Kubozono T., Miyata M., Ohishi M. .  Association of blood pressure and dietary intake of Sunomono, Japanese vinegared side dishes, in community-dwelling Japanese: A cross-sectional study .  Heliyon8 ( 5 ) e09505   2022年5月

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    記述言語:日本語   出版者・発行元:Heliyon  

    Objective: Vinegar has been reported to have a hypotensive effect. We aimed to investigate the relationship between the consumption of vinegar-based side dishes and blood pressure. Research methods & procedures: This cross-sectional study included 746 individuals (257 men and 489 women) aged ≥40 years from Tarumizu, Kagoshima, Japan. Nutrient intake was estimated based on the brief-type self-administered diet history questionnaire. The intake frequency of vinegar-based side dishes (Sunomono and pickles) was determined using a self-administered diet history questionnaire. Participants who did not consume vinegar-based side dishes for a month were defined as having no Sunomono or pickle eating habit. Blood pressure was categorized into four groups according to the Japanese Society of Hypertension Guidelines for the Management of Hypertension. The association between the intake of vinegar-based side dishes and blood pressure categories was analyzed using ordinal logistic regression analysis adjusted for age, body mass index, smoking history, excessive alcohol intake, living situation, energy intake, protein intake, sodium intake, potassium intake, and seaweed intake. Results: Approximately 13.6% men and 6.1% women had no Sunomono eating habits. In men, eating Sunomono, but not pickles, was significantly related to blood pressure categories (estimate, −0.702; 95% CI, −1.122 to −0.310), whereas more frequent consumption of Sunomono did not show an improvement in the blood pressure category. The relationship between eating Sunomono and blood pressure categories was not recognized in women. Conclusion: This was the first study assessing the association between consumption of vinegar-based side dishes and blood pressure categories. We highlighted the effect of Sunomono consumption on blood pressure categories in men. Consumption of Sunomono may improve blood pressure in men.

    DOI: 10.1016/j.heliyon.2022.e09505

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  • Yamakiri K., Sakamoto T., Koriyama C., Kawasaki R., Baba T., Nishitsuka K., Koto T., Terasaki H. .  Effect of surgeon-related factors on outcome of retinal detachment surgery: analyses of data in Japan-retinal detachment registry .  Scientific reports12 ( 1 ) 4213   2022年3月

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    記述言語:日本語   出版者・発行元:Scientific reports  

    The purpose of this study was to investigate the effects of surgeon-related factors on the surgical outcome of pars plana vitrectomy (PPV) and scleral buckling (SB) surgery on eyes with a rhegmatogenous retinal detachment (RRD). This was a nationwide, multicenter, observational study of the data in the Japan-RD Registry. Registered cases that had undergone surgery for a RRD by 128 accredited surgeons in 26 institutions were studied. The surgeon-related factors that significantly affected surgical success and visual outcomes of simple RRD treated by PPV or SB at 6 months postoperatively were analyzed and compared. Among 3446 registered cases, 2533 cases met the inclusion criteria with 1896 in the PPV group and 637 cases in the SB group. The median total number of lifetime cases was 150 and the rate of surgeries/year was 22. Multivariate regression analyses showed that the number and rate of surgeries/year were not significantly associated with the surgical outcome in the PPV group. However, surgeons with a higher average annual number of surgeries had significantly better surgical outcomes in the SB group (P = 0.038). Analyses of a nationwide registry showed that SB but not PPV surgeries require sufficient experience and case numbers to acquire and maintain skills to treat RRDs successfully.

    DOI: 10.1038/s41598-022-07838-5

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  • Goto A., Williams A.L., Okabe S., Koyama Y., Koriyama C., Murakami M., Yui Y., Nollet K.E. .  Empowering Children as Agents of Change to Foster Resilience in Community: Implementing “Creative Health” in Primary Schools after the Fukushima Nuclear Disaster .  International Journal of Environmental Research and Public Health19 ( 6 )   2022年3月

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    記述言語:日本語   出版者・発行元:International Journal of Environmental Research and Public Health  

    The “Creative Heath” project, a participatory school activity to foster community resilience, was implemented in Fukushima, Japan, and children’s experiences of the project were assessed both quantitatively and qualitatively. The project consists of three workshops: BODY, FOOD, and ACT, with activities to facilitate students’ scientific and creative thinking, working in teams, presenting, and expressing their opinions. The first two schools participated with 105 students aged 9–11 years old. Before and after each workshop, students were given questionnaires to rate their satisfaction with their own health (BODY), local foods (FOOD), and the community at large (ACT) on a five-level scale, with space to add free comments. Ratings for BODY and FOOD changed significantly, and the proportion of students who increased their rating of an evaluation indicator after each workshop was 25% for BODY, 28% for FOOD, and 25% for ACT. Text analysis of free comments showed that students in the “increased” group appreciated presenting, measuring, learning connections between nutrition and health, and working collaboratively with peers. Children perceived their health and the foods in their community more positively after participating. Moreover, the Creative Health project could be a way to enhance children’s creativity and autonomy as agents of change in the community.

    DOI: 10.3390/ijerph19063417

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  • Indo H., Ito H., Koriyama C., Majima H.J., Shimada K., Tamatsu Y. .  Deciduous teeth development in fetuses using postmortem computed tomography image analysis .  Legal Medicine54   101969   2022年2月

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    記述言語:日本語   出版者・発行元:Legal Medicine  

    Fetal age is estimated widely by body length and weight and skeletal or dental development and maturation. Regarding dental development, dental development charts reported by Schour and Massler and Ubelaker are well known. We tried to calculate the calcification rate of the deciduous teeth, mandibular cortical bone, and clavicle in fetuses utilizing postmortem computed tomography (CT) image analysis. The CT values within the circumferential area of the region of interest were automatically calculated using a software, and the calcification rate was calculated by performing single regression analysis. Our results showed that deciduous tooth calcification could be detected in over 19-week-old fetuses using CT images. The calcification of bones (mandibular cortical bone and clavicle) started earlier than the calcification of deciduous teeth. However, the calcification rate of the bones was slower compared to that of the deciduous teeth. The calcification rate of the deciduous teeth in fetuses using CT value may be effective to estimate fetal age and evaluate deciduous teeth development, suggesting that our established method is effective for age estimation in forensic dentistry.

    DOI: 10.1016/j.legalmed.2021.101969

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  • Indo Hiroko, Ito Hiromu, Koriyama Chihaya, Majima Hideyuki J., Shimada Kazuyuki, Tamatsu Yuichi .  死後CT画像解析による胎児乳歯の発達(Deciduous teeth development in fetuses using postmortem computed tomography image analysis) .  Legal Medicine54   1 - 6   2022年2月

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    記述言語:英語   出版者・発行元:エルゼビア・ジャパン(株)  

    胎齢の推定法を確立するため、死後CT画像解析から胎児の乳歯歯胚、下顎皮質骨と鎖骨の石灰化速度を計測した。なお、本報では医学教育のため献体された胎児25体(男児13体、女児12体、死亡時胎齢13~33週齢)を用いて、関心領域の円周領域内CT値はソフトウェアで自動計算し、石灰化速度は単回帰分析から求めた。その結果、CT画像から、胎齢19週齢以上の胎児乳歯歯胚の石灰化が検出され、下顎皮質骨と鎖骨の石灰化は、乳歯の石灰化よりも早期に開始されていたが、下顎皮質骨と鎖骨の石灰化速度は、乳歯よりも遅かった。これらの所見から、CT値を用いた胎児石灰化速度が、胎齢の推定と乳歯歯胚発達の評価に有効で、法歯学領域での年齢推定に本法が有用と判断された。

  • Athira Nandakumar, Ananthakrishnakurup Sreekumar, TP Abhilash, Jayalekshmi Padmavathy Amma, Riyaz Ahammed, Rekha A Nair, Raghu Ram K Nair, Chihaya Koriyama, Michiya Sasaki, Suminori Akiba, Seiichi Nakamura, Junji Konishi, Keigo Endo .  Natural radiation exposure and carotid intima-media thickness among women in Karunagappally, Kerala, India .  Angiology Open Access10   294   2022年査読 国際共著

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Kudo H., Yoshinaga S., Li X., Lei S., Zhang S., Sun Q., Koriyama C., Akiba S., Tokonami S. .  The First Attempt to Reevaluate Radon and Thoron Exposure in Gansu Province Study Using Radon-Thoron Discriminating Measurement Technique .  Frontiers in Public Health9   764201   2021年11月

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    記述言語:日本語   出版者・発行元:Frontiers in Public Health  

    Although the epidemiological studies provide evidence for an increased risk of lung cancer risk associated with residential radon, an issue of radon-thoron discrimination remains to be solved. In this study, an updated evaluation of lung cancer risk among the residents in Gansu, China was performed where one of the major epidemiological studies on indoor radon demonstrated an increased risk of lung cancer. We analyzed data from a hospital-based case-control study that included 30 lung cancer cases and 39 controls with special attention to internal exposure assessment based on the discriminative measurement technique of radon isotopes. Results from the analyses showed non-significant increased lung cancer risks; odds ratios (ORs) adjusted for age, smoking, and total income were 0.35 (95% CI: 0.07–1.74) and 0.27 (95% CI: 0.04–1.74) for groups living in residences with indoor radon concentrations of 50–100 Bq m−3 and over 100 Bq m−3, respectively, compared with those with < 50 Bq m−3 indoor radon concentrations. Although the small sample size hampers the usefulness of present analyses, our study suggests that reevaluation of lung cancer risk associated with residential radon in the epidemiological studies will be required on the basis of precise exposure assessment.

    DOI: 10.3389/fpubh.2021.764201

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  • Jayalekshmi P.A., Nandakumar A., Nair R.A., Akiba S., Koriyama C. .  Esophageal cancer in relation to alcohol drinking and tobacco use among men in Kerala, India – Karunagappally cohort .  Cancer Epidemiology74   102018   2021年10月

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    記述言語:日本語   出版者・発行元:Cancer Epidemiology  

    Background: In the Karunagappally cohort, esophageal cancer is the third most common cancer with an age-adjusted incidence rate of 6.2 per 100,000 person-years among men. The present study analyzed the risk of esophageal cancer in relation to alcohol drinking and tobacco use. Methods: The study included 65,528 men aged 30–84 years in the Karunagappally cohort, India. Results: Poisson regression analysis showed that alcohol drinking significantly increased (P = 0.027) the risk of esophageal cancer and the relative risk (RR) for current drinkers was 1.6, (95 % confidence interval (CI) = 1.1–2.3). The risk increased significantly in heavy alcohol drinkers (250 g of ethanol or above per day) (RR = 2.1, 95 % CI = 1.2–3.5) (P for trend = 0.014) and among current arrack consumers (RR = 1.8, 95 % CI = 0.99–3.29) (P for trend = 0.025). Current bidi and cigarette smokers showed an increase in the trend of cancer risk. A significantly higher risk was seen in those who had started smoking bidi before the age of 18 years, RR = 1.9 (95 % CI = 1.1–3.3) (P for trend = 0.044). Furthermore, increased RR for heavy bidi and cigarette smokers were 1.6 (95 % CI = 1.1–2.5) and 2.4 (95 % CI = 1.3–4.5), respectively. Conclusion: To the best of our knowledge, this is the first cohort study in India to report an increased esophageal cancer risk with respect to alcohol drinking.

    DOI: 10.1016/j.canep.2021.102018

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  • 秋葉 澄伯, 平井 みどり, 糠塚 康江, 相澤 彰子, 小松 浩子, 髙井 伸二, 石川 冬木, 岡本 尚, 神尾 陽子, 郡山 千早, 高倉 弘喜, 中川 晋一, 三鴨 廣繁 .  日本学術会議第二部大規模感染症予防・制圧体制検討分科会が2020年7月に発出した提言「感染症の予防と制御を目指した常置組織の創設について」 .  学術の動向26 ( 9 ) 9_29 - 9_36   2021年9月

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    記述言語:日本語   出版者・発行元:公益財団法人 日本学術協力財団  

    <p> 新型コロナウイルス感染症のパンデミックに鑑み、日本学術会議は第二部大規模感染症予防・制圧体制検討分科会を設置した。分科会は「大規模感染症発生後の緊急時に適切な専門家組織を構築し、必要な科学的検討を行い、それに基づいた対策を立案する必要がある。しかし、急遽立ち上げられた組織・体制が短時間で予算を確保し、時宜を得て対策を実施することは困難である。平時からの訓練、ネットワーク構築、必要な体制と法の整備などが重要である。」との結論を得て、2020年7月に表記の提言を発出した。本論考ではその内容を解説した。わが国では、新型コロナウイルス感染症流行が始まって1年以上を経た現在でも必要・十分な対応・対策をとれる体制が確立されていない。自然界に潜む病原体が経済活動や気候変動により人や家畜に侵入し、グローバル化により世界各地に広まることが懸念される中、本提言の内容が今後の感染症対策に役立つことを期待したい。</p>

    DOI: 10.5363/tits.26.9_29

  • OTSUKA T., UEDA K., FURUKAWA T., KORIYAMA C., INOUE I., SATO M. .  Significance of mitochondrial dna haplogroup on epidermal growth factor receptor mutation in japanese patients with lung adenocarcinoma .  Anticancer Research41 ( 8 ) 3997 - 4004   2021年8月

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    記述言語:日本語   出版者・発行元:Anticancer Research  

    Background/Aim: The frequency of somatic mutations of epidermal growth factor receptor (EGFR) in primary lung adenocarcinoma varies among populations and countries. The aim of the present study was to clarify whether the frequency of EGFR mutations in patients with lung adenocarcinoma depends on their mitochondrial DNA haplogroup, which reflects their maternal lineage. Patients and Methods: Using normal lung tissue specimens, the mitochondrial DNA haplogroup was determined by multiplex polymerase chain reaction in 135 Japanese patients who underwent surgery for primary lung adenocarcinoma. Results: The 135 patients were divided into two groups according to the two primitive haplotypes (N group, n=32; M group, n=103). The frequency of EGFR mutations in the N group was significantly higher than that in the M group (69% vs. 48%, p=0.044). The difference was prominent when the analysis was restricted to non-smokers (95% vs. 57%, p<0.01). Conclusion: The frequency of EGFR mutations in lung adenocarcinoma patients depends on their mitochondrial lineage.

    DOI: 10.21873/anticanres.15197

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  • Sasaki K. .  Comparison of greater curvature and lesser curvature circular-stapled esophagogastrostomy after esophagectomy in patients with esophageal cancer: a prospective randomized controlled trial .  Surgery Today51 ( 4 ) 575 - 581   2021年4月国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Surgery Today  

    Purpose: Using a circular stapler to create an anastomosis for esophagogastrostomy after esophagectomy is well accepted; however, it remains uncertain if the greater curvature (GC) or lesser curvature (LC) of the gastric conduit is better for the anastomosis. We conducted this prospective study to compare the integrity of esophagogastrostomy between the esophagus and the GC or LC side of the gastric conduit. Methods: The subjects of this study were 70 patients who underwent esophagectomy and were randomized to a “GC” group and an “LC” group (n = 35 each). The primary and secondary end points were anastomotic leakage (AL) and anastomotic stricture (AS), respectively. Results: The overall AL rate was 22.1%, without a significant difference between the groups. Stump leakage developed in eight of nine patients in the GC group, whereas leakage developed at the esophagogastric anastomosis in five of six patients in the LC group. The rate of stump leakage was significantly higher than that of esophagogastric AL in the GC group. The overall AS rate was 4.4%, with a significant difference between the groups (0% in the GC group vs. 9.1% in the LC group). Conclusions: AL rates were comparable in the two groups, but the sites of leakage were significantly different.

    DOI: 10.1007/s00595-020-02147-8

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  • Kaimoto Kaori, Yamashita Mikako, Suzuki Taro, Makizako Hyuma, Koriyama Chihaya, Kubozono Takuro, Takenaka Toshihiro, Ohishi Mitsuru, Kanouchi Hiroaki, the Tarumizu Study Diet Group .  Association of Protein and Magnesium Intake with Prevalence of Prefrailty and Frailty in Community-Dwelling Older Japanese Women(和訳中) .  Journal of Nutritional Science and Vitaminology67 ( 1 ) 39 - 47   2021年2月

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    記述言語:英語   出版者・発行元:(公社)日本栄養・食糧学会  

    高齢者815名(女性515名、平均74.9歳)を対象に、栄養素摂取状況とプレフレイル(疲労感、動作緩慢、虚弱、活動量低下、または体重減少のいずれか一つ以上の存在)との関係について検討した。男性の52%および女性の54%がプレフレイルに該当した。男性では栄養素摂取状況とプレフレイルの間に有意な関連はみられなかった。女性の場合、健常群と比較して、プレフレイル群はビタミンKとB群(B1、B2、葉酸、パントテン酸)、リン、カリウム、カルシウム、マグネシウム、鉄、亜鉛、銅の摂取量が有意に少なかった。このうちプレフレイルに関連する有意な変数として抽出されたのはマグネシウムのみであった。マグネシウム摂取量の四分位別にみた女性のプレフレイルの調整オッズ比(95%信頼区間)は、第1分位を基準として、第2分位が0.52(0.29~0.92,p=0.024)、第3分位が0.51(0.28~0.95,p=0.033)、第4分位が0.38(0.19~0.74,p=0.005)であった。以上から、高齢日本人女性において、マグネシウムはプレフレイル予防に重要な栄養素であると考えられた。

  • KAIMOTO Kaori, YAMASHITA Mikako, SUZUKI Taro, MAKIZAKO Hyuma, KORIYAMA Chihaya, KUBOZONO Takuro, TAKENAKA Toshihiro, OHISHI Mitsuru, KANOUCHI Hiroaki, theTarumizuStudyDietGroup .  Association of Protein and Magnesium Intake with Prevalence of Prefrailty and Frailty in Community-Dwelling Older Japanese Women .  Journal of Nutritional Science and Vitaminology67 ( 1 ) 39 - 47   2021年国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:一般財団法人 学会誌刊行センター  

    <p>We examined the association between nutrient intake and prefrailty. Data from 815 older people (63% women) who participated in a community-based health check survey (Tarumizu Study) were analyzed. Prefrailty were defined using five parameters (exhaustion, slowness, weakness, low physical activity, and weight loss). Participants with one or more components were considered to belong to the prefrailty group. Nutrition intake was estimated from a validated brief-type self-administered diet history questionnaire. Among the participants, 154 men (52%) and 278 women (54%) were found to be in a status of prefrailty. In men, there were no significant associations between nutrient intake and prefrailty. In women, carbohydrate intake was slightly higher in prefrailty group. Vitamins K, B<sub>1</sub>, B<sub>2</sub>, folic acid, pantothenic acid, phosphorus, potassium, calcium, magnesium, iron, zinc, and copper intake was significantly lower in the prefrailty group. Among the nutrients, magnesium was identified as a significant covariate of prefrailty using a stepwise regression method. In women adjusted ORs (95%CI, <i>p</i> value) for prefrailty in the first, second, third, and fourth quartiles of magnesium intake were 1.00 (reference), 0.52 (0.29–0.92, 0.024), 0.51 (0.28–0.95, 0.033), and 0.38 (0.19–0.74, 0.005), respectively, by multivariate logistic regression analysis (variates: age, body mass index, energy intake, supplement use, osteoporosis, magnesium, and protein intake). Protein intake did not related to prefrailty. Protein intake might be sufficient to prevent prefrailty in the present study. We propose magnesium to be an important micronutrient that prevents prefrailty in community-dwelling older Japanese women.</p>

    DOI: 10.3177/jnsv.67.39

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  • Funatsu R., Terasaki H., Koriyama C., Yamashita T., Shiihara H., Sakamoto T. .  Silicone oil versus gas tamponade for primary rhegmatogenous retinal detachment treated successfully with a propensity score analysis: Japan Retinal Detachment Registry .  British Journal of Ophthalmology106 ( 8 ) 1044 - 1050   2021年

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    記述言語:日本語   出版者・発行元:British Journal of Ophthalmology  

    Background/aims: To compare the effects of silicone oil tamponade (SOT) to that of gas tamponade (GT) on the best-corrected visual acuity (BCVA) after successful vitrectomy for retinal detachment (RD). Methods: A retrospective, multicentre, nationwide study with RD who were registered in the Japan-RD Registry. All cases with RD treated with successful vitrectomy between February 2016 and March 2017 were studied. A propensity score matching was performed using the preoperative findings as covariates to adjust the relevant confounders. The primary outcome was the estimated mean difference of the postoperative BCVA in 6 months between eyes treated with SOT to those treated with GT. Results: Of the 3446 cases registered, 2097 cases met the entry criteria. There were 2042 eyes that had GT and 55 eyes that had SOT. Primary success was defined as a reattached retina with no tamponade at 6 months. After propensity score matching, each group contained 40 cases. The preoperative BCVA was 0.966±0.738 logMAR units in the GT group and 1.270±0.945 logMAR units in the SOT group (p=0.177). Six months postoperatively, the BCVA in the GT group was significantly better at 0.309 logMAR units in the GT group than the 0.671 logMAR units in the SOT group (p=0.002). Conclusions: Even after successful surgery for RD, eyes that experienced SOT had poorer BCVA than eyes treated with GOT. SOT should be considered cautiously. Precis: Propensity score analysis of eyes with rhegmatogenous RD showed that postoperative vision was worse in eyes treated once with silicone oil than with gas even after completely successful surgery.

    DOI: 10.1136/bjophthalmol-2021-319876

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  • Muniroh M. .  Activation of MIP-2 and MCP-5 Expression in Methylmercury-Exposed Mice and Their Suppression by N-Acetyl-L-Cysteine .  Neurotoxicity Research37 ( 4 ) 827 - 834   2020年4月国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Neurotoxicity Research  

    DOI: 10.1007/s12640-020-00174-4

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  • Tsuji Mayumi, Koriyama Chihaya, Ishihara Yasuhiro, Yamamoto Megumi, Yamamoto-Hanada Kiwako, Kanatani Kumiko, Bamai Yu Ait, Onishi Kazunari, Senju Ayako, Araki Shunsuke, Shibata Eiji, Morokuma Seiichi, Sanefuji Masafumi, Kitazawa Hiroshi, Saito Mayako, Umezawa Masakazu, Onoda Atsuto, Kusuhara Koichi, Tanaka Rie, Kawamoto Toshihiro .  日本の子どもの健康と環境に関する全国調査のデータを用いた妊婦の全血金属濃度とIgE濃度の関連性分析(Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study) .  Journal of Epidemiology29 ( 11-12 ) 478 - 486   2019年12月

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    出版者・発行元:日本疫学会  

    <Highlight>●妊婦を対象に抗原特異的IgE抗体と血中金属濃度との関係を調べた。●抗原特異的IgE抗体は2群(低値群<0.35UA/ml,高値群≧0.35UA/ml)に分けて解析された。●スギ特異的IgE抗体と血中水銀およびセレン濃度の間に正の相関が認められた。●ハウスダストおよび動物上皮特異的IgE抗体と血中水銀濃度の間に負の相関が認められた。(著者抄録)

  • 152. Ananthakrishnakurup Sreekumar, PadmavathyAmma Jayalekshmi, Athira Nandakumar, Raghu Ram K. Nair, Riyaz Ahammed, Paul Sebastian, Chihaya Koriyama, Suminori Akiba, Seiichi Nakamura, Junji Konishi .  Thyroid Nodule Prevalence among Women in Areas of High Natural Background Radiation, Karunagappally, Kerala, India .  Endocrine   2019年10月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s12020-019-02071-z

  • Kawaike Y. .  Working Memory-Related Prefrontal Hemodynamic Responses in University Students: A Correlation Study of Subjective Well-Being and Lifestyle Habits .  Frontiers in Behavioral Neuroscience13   213   2019年9月

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    出版者・発行元:Frontiers in Behavioral Neuroscience  

    DOI: 10.3389/fnbeh.2019.00213

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  • 154. Aryal B, Yamakuchi M, Shimizu T, Kadono J, Furoi A, Gejima K, Komokata T, Koriyama C, Hashiguchi T, Imoto Y .  Predictive value of diminished serum PDGF-BB after curative research of hepatocellular cancer .  J Oncology   2019年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1155/2019/1925315

  • Tsuji M, Koriyama C, Ishihara Y, Vogel CFA, Kawamoto T .  Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children .  European Journal of Medical Research23 ( 1 ) 61   2018年12月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s40001-018-0358-1

  • Tsuji M, Shibata E, Morokuma S, Tanaka R, Senju A, Araki S, Sanefuji M, Koriyama C, Yamamoto M et al. .  The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS) .  Environmental Research166   562 - 569   2018年10月招待 査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.envres.2018.06.025

  • Ko K.P. .  Plasma phytoestrogens concentration and risk of colorectal cancer in two different Asian populations .  Clinical Nutrition37 ( 5 ) 1675 - 1682   2018年10月

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    出版者・発行元:Clinical Nutrition  

    DOI: 10.1016/j.clnu.2017.07.014

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  • Tsuji M. .  Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory .  Environmental Health and Preventive Medicine23 ( 1 ) 24   2018年6月

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    出版者・発行元:Environmental Health and Preventive Medicine  

    DOI: 10.1186/s12199-018-0713-4

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  • Tsuji Mayumi, Ishihara Yasuhiro, Isse Toyohi, Koriyama Chihaya, Yamamoto Megumi, Kakiuchi Noriaki, Yu Hsu-Sheng, Tanaka Masayuki, Tsuchiya Takuto, Ohta Masanori, Tanaka Rie, Kawamoto Toshihiro .  ウレタンフォーム工場の男性労働者における化学物質特異的IgG抗体の評価(Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory) .  Environmental Health and Preventive Medicine23 ( June ) 1 - 6   2018年6月

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    出版者・発行元:(一社)日本衛生学会  

    ウレタンフォーム工場の男性労働者75名と、同工場で勤務中に呼吸器症状が悪化し、職業性アレルギー(OA)が疑われる男性2名(43歳、52歳)を対象に、実際のモニタリングにおける複数の化学物質特異的免疫グロブリンG(IgG)評価の有用性について検討した。被験者から血液を採取し、トルエンジイソシアネート(TDI)および無水トリメリット酸(TMI)特異的IgGのレベルを評価した。対照男性87名のTDI特異的IgG濃度は平均0.98μg/mL、TMA特異的IgG濃度は平均2.10μg/mLであった。OAが疑われる2名のTDI特異的IgG濃度は15.6μg/mLと9.51μg/mL、TMA特異的IgG濃度は4.56μg/mLと14.4μg/mLで、対照男性よりも著明に上昇していた。男性労働者75名のTDI特異的IgG濃度は平均1.89μg/mL、TMA特異的IgG濃度は平均2.41μg/mLで、いずれも対照男性よりも有意に上昇していた(それぞれp<0.001,p<0.026)。プラスチック樹脂を用いる労働者において、TDIおよびTMA特異的IgGの評価は、曝露状況のモニタリングに有用であることが示された。

  • Ishihara Yasuhiro, Ikeda-Ishihara Nami, Koriyama Chihaya, Kakiuchi Noriaki, Tanaka Masayuki, Vogel Christoph F.A., Kawamoto Toshihiro, Tsuji Mayumi .  ヒト血清アルブミンの部分ペプチドを用いたELISAによる血清中の化学物質特異的IgGの測定(Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay with partial peptides of human serum albumin) .  The Journal of Toxicological Sciences43 ( 1-3 ) 25 - 31   2018年3月

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    出版者・発行元:(一社)日本毒性学会  

    ヒト血清アルブミン(HSA)部分ペプチドを用いたELISAにより、血清中の化学物質特異的免疫グロブリンG(IgG)の定量分析を行った。リジン残基を含むHSA部分ペプチドをホルムアルデヒド(FA)または無水フタル酸(PA)と混合して、ペプチド中のリジン残基とそれぞれイミンまたは3級アミンを形成させ、血清中のFAおよびPA特異的IgG検出用の人工抗原であるFAおよびPAペプチド付加物を調製した。プラスチック樹脂を用いる工場労働者および一般被験者の血清を採取し、HSAペプチドを用いたELISAでFAおよびPA特異的IgGを測定したところ、工場労働者の特異的IgGは、一般被験者よりも有意に高かった。本法は化学物質への曝露レベル推定が可能で、労働者のアレルギー診断や有害化学物質による健康障害の防止に寄与することが示唆された。

  • Sakamoto M. .  Placental transfer and levels of mercury, selenium, vitamin E, and docosahexaenoic acid in maternal and umbilical cord blood .  Environment International111   309 - 315   2018年2月国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Environment International  

    DOI: 10.1016/j.envint.2017.11.001

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  • 142. Yasuhiro Ishihara, Nami Ikeda-Ishihara, Chihaya Koriyama, Noriaki Kakiuchi, Masayuki Tanaka, Christoph F.A. Vogel, Toshihiro Kawamoto, Tsuji Mayumi .  Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay with partial peptides of human serum albumin .  The Journal of Toxicological Sciences43 ( 1 ) 25 - 31   2018年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Mayumi Tsuji, Yasuhiro Ishihara, Toyohi Isse, Chihaya Koriyama, Megumi Yamamoto, Noriaki Kakiuchi, Hsu-Sheng Yu, Masayuki Tanaka, Takuto Tsuchiya, Masanori Ohta, Rie Tanaka, Toshihiro Kawamoto .  Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory .  Environmental Health and Preventive Medicine   2018年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Shinmura K. .  Comparison of conservative treatment versus transcatheter arterial embolisation for the treatment of spontaneously ruptured hepatocellular carcinoma .  Polish Journal of Radiology83   e311 - e318   2018年国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Polish Journal of Radiology  

    DOI: 10.5114/pjr.2018.77024

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  • Ueyama T. .  Risk factors for radiation pneumonitis after stereotactic radiation therapy for lung tumours: Clinical usefulness of the planning target volume to total lung volume ratio .  British Journal of Radiology91 ( 1086 ) 20170453   2018年

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    出版者・発行元:British Journal of Radiology  

    DOI: 10.1259/bjr.20170453

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  • Ishihara Yasuhiro, Ikeda-Ishihara Nami, Koriyama Chihaya, Kakiuchi Noriaki, Tanaka Masayuki, Vogel Christoph F.A., Kawamoto Toshihiro, Tsuji Mayumi .  Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay with partial peptides of human serum albumin .  The Journal of Toxicological Sciences43 ( 1 ) 25 - 31   2018年

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    出版者・発行元:日本毒性学会  

    <p>Many different types of chemicals are used in industry, and occupational allergies are becoming a serious problem in the field of industrial hygiene. In this study, we employed a novel enzyme-linked immunosorbent assay (ELISA) with partial peptides of human serum albumin (HSA) to quantify chemical-specific immunoglobulin G (IgG) in serum for evaluating exposure to chemicals. When HSA partial peptides containing lysine residues were mixed with formaldehyde (FA) or phthalic anhydride (PA), almost all lysine residues were lost. Mass spectrometry revealed that PA and FA formed imine and tertiary amine, respectively, with lysine residues in the peptides. Thus, we used FA- or PA-peptide adducts as an artificial antigen to detect FA- and PA-specific IgGs in serum. The concentrations of FA- and PA-specific IgGs in workers at plants utilizing plastic resins were significantly higher than those in general subjects. This method can estimate exposure levels to chemicals and thus be expected to contribute to the diagnosis of allergies in workers and to the prevention of health hazards due to harmful chemicals.</p>

    DOI: 10.2131/jts.43.25

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  • Mineshi Sakamoto, Laurie Chan, Jose Domingo, Chihaya Koriyama, Katsuyuki Murata .  Kinetics of methylmercury, selenium, vitamin E, and docosahexaenoic acid: maternal and fetal transfer .  Environment International   2017年11月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Juliet David, Athira Nandakumar, Muflihatul Muniroh, Suminori Akiba, Megumi Yamamoto, Chihaya Koriyama .  Suppression of methylmercury-induced MIP-2 expression by N-acetyl-L-cysteine in murine RAW264.7 macrophage cell line .  European Journal of Medical Research   2017年11月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • David J. .  Suppression of methylmercury-induced MIP-2 expression by N-acetyl-l-cysteine in murine RAW264.7 macrophage cell line .  European Journal of Medical Research22 ( 1 ) 45   2017年11月

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    出版者・発行元:European Journal of Medical Research  

    DOI: 10.1186/s40001-017-0287-4

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  • Toyota M. .  Comparison of the peripheral doses from different IMRT techniques for pediatric head and neck radiation therapy .  Radiation Protection Dosimetry176 ( 3 ) 322 - 330   2017年11月国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Radiation Protection Dosimetry  

    DOI: 10.1093/rpd/ncx013

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  • Tran LT, Lai HTM, Koriyama C, Uwatoko F, Akiba S .  The association between high birth weight and the risks of childhood CNS tumors and leukemia: an analysis of a US case-control study in an epidemiological database .  BMC Cancer   2017年10月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Hoang Thi Van Anh, Do Thi Thu Hien, Agusa Tetsuro, Koriyama Chihaya, Akiba Suminori, Ishibashi Yasuhiro, Sakamoto Mineshi, Yamamoto Megumi .  ハノイにおけるベトナム人の魚食と関連する毛髪水銀値(Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi) .  The Journal of Toxicological Sciences42 ( 5 ) 651 - 662   2017年10月

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    出版者・発行元:(一社)日本毒性学会  

    メチル水銀(MeHg)の曝露状況を調べるため、ハノイ在住のベトナム人196名(男性99名、女性97名、年齢16〜55歳)を対象に、毛髪水銀値と足指爪中のセレン(Se)濃度および魚食との関連を評価した。魚食に関する情報は食事質問票を用いて評価した。男性と女性の毛髪水銀値の幾何学的平均はそれぞれ617ng/gおよび575ng/gであった。本ベトナム人被験者の98%の毛髪水銀値はMeHgに対する暫定的耐容1週摂取量(1.6μgHg/kg体重:6.4の不確実性因子にて約2300ng/gの毛髪水銀濃度に相当)より低かった。新鮮な魚食頻度に関係する女性の毛髪水銀値の年齢調整幾何学的平均において有意差があった。毛髪水銀値と足指爪中のSe濃度は魚食頻度の増加にともなって増加し、海産魚≧1回/週を食した被験者では有意な正相関を示した。

  • Ko KP, Yeo Y, Yoon JH, Kim CS, Tokudome S, Ngoan LT, Koriyama C, Lim YK, Chang SH, Shin HR, Kang D, Park SK, Kang CH, Yoo KY .  Plasma phytoestrogens concentration and risk of colorectal cancer in two different Asian populations .  Clinical Nutrition   2017年7月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Nandakumar A. .  Radiation-induced Epstein-Barr virus reactivation in gastric cancer cells with latent EBV infection .  Tumor Biology39 ( 7 ) 1 - 9   2017年7月

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    出版者・発行元:Tumor Biology  

    DOI: 10.1177/1010428317717718

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  • Jinguji M. .  Thymic involution after radioiodine therapy for graves disease: Relationships with serum thyroid hormones and TRAb .  Journal of the Endocrine Society1 ( 7 ) 852 - 860   2017年7月

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    出版者・発行元:Journal of the Endocrine Society  

    DOI: 10.1210/js.2017-00182

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  • Samukawa T. .  Development of a self-scored persistent airflow obstruction screening questionnaire in a general Japanese population: The Hisayama study .  International Journal of COPD12   1469 - 1481   2017年5月国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of COPD  

    DOI: 10.2147/COPD.S130453

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  • Okita Shinobu, Daitoku Satoshi, Abe Masaharu, Arimura Emi, Setoyama Hitoshi, Koriyama Chihaya, Ushikai Miharu, Kawaguchi Hiroaki, Horiuchi Masahisa .  日本人新人看護師における職業性ストレス感受性の予測因子 予備的研究(Potential predictors of susceptibility to occupational stress in Japanese novice nurses: a pilot study) .  Environmental Health and Preventive Medicine22 ( April ) 1 - 11   2017年4月

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    出版者・発行元:(一社)日本衛生学会  

    当大学病院の女性新人看護師を対象に、職業性ストレスに対する感受性の潜在的な予測因子を評価した。看護師62名にBrief Job Stress Questionnaireを行い、最終的に42名(年齢21〜24歳)を解析対象とした。全員に健康診断と泌尿器検査を行い、就職時に生活習慣に関する質問票調査を行った。登録から5ヵ月の時点で三つのストレス状態スコアが全て有意に低下し、職業性ストレス状態であることが示唆された。収縮期血圧(r=-0.324、p<0.05)と尿中ナトリウム(r=-0.313、p<0.05)は登録から5ヵ月後のBJSQスコアと有意に負の相関があった。登録後のストレス状態スコアは、1年間の体重変化が±3kg以下および夕食から就寝までが2時間以下の看護師では有意に低かった。尿中ナトリウム、1年間の体重変化、夕食から就寝までの時間は職業性ストレス感受性の予測因子として有望であることが示唆された。

  • Yanazume Shintaro, Orita Yuji, Koriyama Chihaya, Niihara Yuichiro, Kamio Masaki, Togami Shinichi, Douchi Tsutomu, Kobayashi Hiroaki .  婦人科悪性腫瘍手術における創離開に対する皮下ドレーン留置の影響(Impact of subcutaneous drainage on wound disruption in gynecological malignancy surgery) .  鹿児島産科婦人科学会雑誌25   14 - 21   2017年3月

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    出版者・発行元:鹿児島産科婦人科学会  

    1997年1月〜2010年9月に当施設で婦人科悪性腫瘍と診断し、一次治療として手術を施行した患者362例を対象に、皮下ドレーン留置が皮膚吻合後の創離開にどのような影響を及ぼすかを後向きに評価した。皮下ドレーン留置患者(留置群)は131例(平均56.2±14.0歳)、非留置患者(非留置群)は231例(平均54.0±14.6歳)であった。創離開の全発生率は留置群3/131例、非留置群18/231例であった(p=0.031)。創離開率はBMI(p=0.007)、疾患進行度(p=0.002)、手術時間(p=0.013)と正の相関が認められた。多重ロジスティック回帰分析により、肥満、疾患ステージ進行、長い手術時間を創離開の独立したリスクとして特定した。肥満患者では、非留置群の方が創離開率は高かった。以上より、婦人科悪性腫瘍手術時の皮下ドレーン留置は、皮膚吻合後の創離開率を低下させることが示された。

  • Ishidou Yasuhiro, Koriyama Chihaya, Kakoi Hironori, Setoguchi Takao, Nagano Satoshi, Hirotsu Masataka, Yamamoto Takuya, Yokouchi Masahiro, Komiya Setsuro .  鹿児島県における大腿骨近位部骨折手術後の死亡および日常生活動作能力低下の予測因子(Predictive factors of mortality and deterioration in performance of activities of daily living after hip fracture surgery in Kagoshima, Japan) .  Geriatrics & Gerontology International17 ( 3 ) 391 - 401   2017年3月

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    出版者・発行元:John Wiley & Sons Australia, Ltd  

    大腿骨近位部骨折手術1年後の日常生活動作(ADL)能力および生存に影響を及ぼす因子を明らかにすることを目的とした。鹿児島県内の33医療施設で治療を受けた患者387例を対象とする多施設共同前向きコホート研究を実施した。ロジスティック回帰分析においてBarthel Index(BI)の悪化リスクと有意な関連を示した術前因子は、加齢、骨折前BIの不良、大腿骨転子部骨折、術後因子は退院時BIの不良、認知障害であった。また退院後に疾患を新規発症した患者ではBI悪化のオッズ比が有意に高かった。死亡リスクと有意な関連を示した術前因子は年齢と性別のみで、それらの影響を調整後、術後因子としては退院時BIが唯一の有意な死亡リスク決定因子であった。退院時にADL能力が不良な患者は、手術1年後における機能の回復が不良で、死亡率が高い傾向にあることが示された。

  • Nandakumar A, Uwatoko F, Yamamoto M, Tomita K, Majima H, Akiba S, Koriyama C .  Radiation-induced Epstein-Barr virus reactivation in gastric cancer cells with latent EBV infection .  Tumor Biology39 ( 7 )   2017年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 138. Hoang VAT, Do HTT, Agusa T, Koriyama C, Akiba S, Ishibashi Y, Sakamoto M, Yamamoto M .  Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi .  The Journal of Toxicological Sciences42 ( 5 ) 651 - 662   2017年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Hoang Van Anh Thi, Do Hien Thu Thi, Agusa Tetsuro, Koriyama Chihaya, Akiba Suminori, Ishibashi Yasuhiro, Sakamoto Mineshi, Yamamoto Megumi .  Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi .  The Journal of Toxicological Sciences42 ( 5 ) 651 - 662   2017年

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    出版者・発行元:一般社団法人 日本毒性学会  

    <p>People are exposed to methylmercury (MeHg) mainly through fish consumption, which is increasing in Vietnam. However, little information is available on estimating the health risk of MeHg exposure through fish consumption in Vietnam. The present study examined the association between mercury (Hg) levels in hair and selenium (Se) levels in toenails of 196 Vietnamese people and their fish consumption, using a dietary questionnaire to obtain information pertinent for assessing health risk owing to MeHg exposure. The geometric mean of Hg levels in the hair of males and females was 617 ng/g and 575 ng/g, respectively. We found that Hg levels in the hair of 98% of the Vietnamese study subjects were lower than the provisional tolerable weekly intake for MeHg (1.6 µg Hg/kg body weight; which is equivalent to a hair Hg concentration of approximately 2,300 ng/g, with an uncertainty factor of 6.4). There were significant differences in the age-adjusted geometric mean of Hg levels found in hair from females related to their frequency of freshwater fish consumption. The levels of Hg in hair and Se in toenails increased with an increased frequency of marine fish consumption, and both showed a significant positive correlation in subjects who consumed marine fish ≥ once/week. This is the first cross-sectional study to investigate the association between hair Hg levels and fish consumption in Vietnam. These findings provide valuable information for future assessments of the health risk of MeHg exposure through fish consumption in Vietnam.</p>

    DOI: 10.2131/jts.42.651

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  • Okita S. .  Potential predictors of susceptibility to occupational stress in Japanese novice nurses - A pilot study .  Environmental Health and Preventive Medicine22 ( 1 ) 20   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Environmental Health and Preventive Medicine  

    DOI: 10.1186/s12199-017-0641-8

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    PubMed

  • Aryal B. .  Post-resection exhaustion of intra-platelet serotonin: Also an indicator of early hepatocellular carcinoma recurrence? .  Journal of Cancer8 ( 19 ) 3984 - 3991   2017年国際誌

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Cancer  

    DOI: 10.7150/jca.20971

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  • Ordonez P, Nandakumar A, Koriyama C, Yamamoto M, Akiba S .  Cytotoxic effect of NF-kB inhibitors in combination with antiherpes agents on Epstein-Barr virus-positive gastric carcinoma in vitro .  Molecular Medicine Reports   2016年7月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Ishidou Y, Koriyama C, Kakoi H, Setoguchi T, Nagano S, Hirotsu M, Yamamoto Y, Yokouchi M, Komiya S .  Predictive factors of mortality and deterioration in performance of activities of daily living after hip fracture surgery in Kagoshima, Japan .  Geriatrics and Gerontology International   2016年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/ggi.12718

  • Tsuji M, Koriyama C, Yamamoto M, Anan A, Shibata E, Kawamoto T .  The association between maternal psychological stress and inflammatory cytokines in allergic young children .  Peer J   2016年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.7717/peerj.1585

  • Fujio S, Takano K, Arimura H, Habu M, Bohara M, HiranoH, Hanaya R, Nishio Y, Koriyama C, Kinoshita Y, Arita K .  Treatable glomerular hyperfiltration in patients with active acromegaly .  European Journal of Endocrinology   2016年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Tsukuya G, Samukawa T, Matsumoto K, Fukuyama S, Kumamoto T, Uchida A, Koriyama C, Inoue H .  Comparison of the COPD-PS and IPAG questionnaires in a general Japanese population: The Hisayama Study .  International Journal of Chronic Obstructive Pulmonary Disease   2016年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Hassani S, Castillo A, Ohori J, Higashi M, Kurono Y, Akiba S,Koriyama C .  Molecular Pathogenesis of Human Papillomavirus Type 16 in Tonsillar Squamous Cell Carcinoma .  Anticancer Research35 ( 12 ) 6633 - 6638   2015年12月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Institute of Anticancer Research  

    Aim: The present study aimed to explore the etiological role of human papillomavirus (HPV) in tonsillar squamous cell carcinoma (TSCC). Materials and Methods: HPV status, including viral load and E6 variants, and the expression of P53, p16INK4A, and FANCD2, in tissues of TSCC (n=24) and tonsillitis (n=31) were investigated. Results: The frequency of high-risk HPV (HPV-16) in TSCCs (42%) was higher than that of tonsillitis (16%). HPV-16 genome was partially or fully integrated in all HPV-16-positive TSCCs. However, the viral genome was partially integrated in three out of five HPV-16-positive tonsillitis cases (p=0.037). HPV-16-positive TSCCs showed a higher frequency of p16INK4A expression than HPV-16-negative TSCCs and tonsillitis (p=0.011). Regardless of HPV status, TSCCs had a lower expression of FANCD2 than tonsillitis (p=0.008). Conclusion: The present study supports the etiological role of HPV-16 in the development of TSCC, and p16INK4A overexpression can be applied as a surrogate marker for the detection of high-risk-HPV in TSCC.

  • Muniroh M, Khan N, Koriyama C, Akiba S, Vogel CF, Yamamoto M .  Suppression of methylmercury-induced IL-6 and MCP-1 expressions by N-acetylcysteine in U-87MG human astrocytoma cells .  Life Sciences134   16 - 21   2015年8月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevir  

    Aims

    The aim of this study was to clarify the involvement of oxidative stress in methylmercury (MeHg)-induced pro-inflammatory cytokine expressions and the suppressive effects of N-acetylcysteine (NAC) in MeHg-induced cytokine expression.

    Materials and methods

    Using U-87-MG human astrocytoma cell line, interleukin (IL)-6 and monocyte chemoattractant protein (MCP)-1 expressions induced by 4 μM MeHg were measured at mRNA and protein levels. Hydrogen peroxide (H2O2) and superoxide anion (O2−) were quantified by flow-cytometry analysis. To examine the suppressive effects of NAC on the cytokine expressions among different timing of NAC treatment, cells were treated with 0.5 or 5 mM NAC before, simultaneously, or after MeHg administration.

    Key findings

    MeHg exposure at 4 μM, a non-cytotoxic concentration, significantly induced MCP-1 and IL-6 expressions at both mRNA and protein levels. A significant increase of H2O2 production but not O2− was observed. MeHg-induced expression of MCP-1 and IL-6 mRNA was reduced by 10–20% in the presence of 5 mM NAC (co-treatment experiment) compared to cells treated with MeHg only. Pre-treatment of cells with 0.5 or 5 mM NAC at 0.5 or 1 h and its subsequent washout before MeHg addition suppressed MCP-1 and IL-6 cytokine expressions. Post-treatment of cells with NAC after MeHg addition also suppressed the cytokine induction, but the magnitude of suppression was evidently lower than in co-treated cells even though the H2O2 generation was almost completely suppressed by NAC.

    Significance

    NAC may effectively suppress the MeHg-induced cytokine production through both, inhibition of reactive oxygen species as well as extracellular chelation of MeHg in astrocytes.

    その他リンク: http://www.sciencedirect.com/science/journal/00243205/134

  • Sidra Ghani, Noureen Khan, Chihaya Koriyama, Suminori Akiba, Megumi Yamamoto .  N-acetyl-L-cysteine prevents arsenite-induced cytotoxicity mainly through chelation in U937 monocytes and macrophages .  Molecular Medicine Reports10 ( 6 ) 2961 - 2966   2014年12月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Andres Castillo, Lu Wang, Chihaya Koriyama, Yoshito Eizuru, King Jordan, Suminori Akiba .  A systems biology analysis of the changes in gene expression via silencing of HPV-18 E1 expression in HeLa cells .  Open Biology4 ( 10 )   2014年10月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Shibahara H, Higashi M, Koriyama C, Yokoyama S, Kitazono I, Kurumiya Y, Narita M, Kuze S, Kyokane T, Mita S, Arai T, Kato T, Yuasa N, Yamaguchi R, Kubota H, Suzuki H, Baba S, Rousseau K, Batra SK, Yonezawa S .  Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer .  PLoS One9 ( 4 )   2014年4月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Camille Ragin, Monisola Obikoya-Malomo, Sungjin Kim, Zhengjia Chen, Rafael Flores-Obando, Denise Gibbs, Chihaya Koriyama, Francisco Aguayo, Jill Koshiol, Neil E. Caporaso, Giovanna E. Carpagnano, Marco Ciotti, Hirotoshi Dosaka-Akita, Masashi Fukayama, Akiteru Goto, Demetrios A. Spandidos, Vassilis Gorgoulis, Danielle A.M. Heideman, Robert A.A. van Boerdonk, Kenzo Hiroshima, Reika Iwakawa, Nikolaos G. Kastrinakis, Ichiro Kinoshita, Suminori Akiba, Maria T. Landi, H. Eugene Liu, Jinn-Li Wang, Ranee Mehra, Fadlo R. Khuri, Wan-Teck Lim, Taofeek K. Owonikoko, Suresh Ramalingam, Emmanuela Sarchianaki, Kari Syrjanen, Ming-Sound Tsao, Jenna Sykes, Siew Wan Hee, Jun Yokota, Apostolos Zaravinos, Emanuela Taioli .  HPV-associated lung cancers: an international pooled analysis .  Carcinogenesis35 ( 6 ) 1267 - 1275   2014年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Dao ATT, Luong VT, Nguyen TT, Huynh QTV, Phan TTT, Lam MT, Ngoma AM, Koriyama C .  Risk factors for early fatal outcomes among children with hemophagocytic lymphohistiocytosis (HLH): a single-institution case-series in Vietnam .  Pediatric Hematology and Oncology   2013年12月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Jayalekshmi PA, Nandakumar A, Akiba S, Gangadharan P, Koriyama C .  Associations of tobacco use and alcohol drinking with laryngeal and hypopharyngeal cancer risks among men in Karunagappally, Kerala, India -Karunagappally cohort study .  ProsOne   2013年8月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Camargo MC, Koriyama C, Matsuo K, Kim WH, Herrera-Goepfert R, Liao LM, the Eurgast-EPIC Group, Yu J, Carrasquilla G, Sung JJY, Alvarado-Cabrero I, Lissowska J, Meneses-Gonzalez F, Yatabe Y, Ding T, Hu N, Taylor PR, Morgan DR, Gulley ML, Torres J, Akiba S, Rabkin CS .  Case-case comparison of smoking and alcohol risk associations with Epstein-Barr virus-positive gastric cancer .  International Journal of Cancer   2013年7月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • M. Constanza Camargo, Woo-Ho Kim, Anna Maria Chiaravalli, Kyoung-Mee Kim, Alejandro H. Corvalan, Keitaro Matsuo, Jun Yu, Joseph J.Y. Sung , Roberto Herrera-Goepfert, Fernando Meneses-Gonzalez, Yuko Kijima, Shoji Natsugoe , Linda M. Liao, Jolanta Lissowska, Sung Kim, Nan Hu, Carlos A. Gonzalez, Yashushi Yatabe, Chihaya Koriyama, Stephen M. Hewitt, Suminori Akiba, Margaret L. Gulley, Philip R. Taylor, Charles S. Rabkin .  Improved survival of gastric cancer with tumor Epstein-Barr virus positivity: An international pooled analysis .  Gut   2013年4月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Hien Thi Thu Do, Chihaya Koriyama, Noureen Afsar Khan, Michiyo Higashi, Takuya Kato, Ngoan Tran Le, Shigeto Matsushita, Takuro Kanekura, Suminori Akiba .  The etiologic role of human papillomavirus in penile cancers - a study in Vietnam .  British Journal of Cancer108 ( 1 ) 229 - 233   2013年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Kato T, Koriyama C, Khan N, Samukawa T, Yanagi M, Hamada T, Yokomakura N, Otsuka T, Inoue H, Sato M, Natsugoe S, Akiba S .  EGFR mutations and human papillomavirus in lung cancer .  Lung Cancer78 ( 2 ) 144 - 147   2012年11月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Abdirad A, Eram N, Behzadi AH, Koriyama C, Parvaneh N, Akiba S, Kato T, Khan N, Ghofrani M, Sadigh N .  Human papillomavirus detected in esophageal squamous cell carcinoma in Iran .  Eur J Intern Med23 ( 2 ) e59 - 62   2012年3月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Andres Castillo, Chihaya Koriyama, Michiyo Higashi, Muhammad Anwar, Mulazim Hussain Bukhari, Edwin Carrascal, Lida Mancilla, Hiroshi Okumura, Masataka Matsumoto, Kazumasa Sugihara, Shoji Natsugoe, Yoshito Eizuru, Suminori Akiba .  Human papillomavirus in upper digestive tract tumors from three countries .  World Journal of Gastroenterology17 ( 48 )   2011年12月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Paula Ordonez, Chihaya Koriyama, Shan Ding, Elena Yoshiwara, Alejandro H. Corvalan, Juan Takano, Jesus L. Chirinos, Jose Watanabe, Juan Miyagui, Heriberto Hidalgo, Pedro Chacon, Victor Linares, Yoshito Eizuru, Suminori Akiba .  Identification of The Distinctive Type i/XhoI+ Strain of Epstein-Barr Virus in Gastric Carcinoma in Peru .  Anticancer Research   2011年10月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Camargo MC, Murphy G, KORIYAMA Chihaya, Pfeiffer RM, Kim WH, Herrera-Goepfert R, Corvalan AH, Carrascal E, Abdirad A, Anwar M, Hao Z, Kattoor J, Yoshiwara-Wakabayashi E, EIZURU Yoshito, Rabkin CS, AKIBA Suminori .  Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis .  Br J Cancer   2011年6月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Nomura Y, Arata M, Koriyama C, Masuda K, Morita Y, Hazeki D, Ueno K, Eguchi T, Kawano Y. .  A severe form of Kawasaki Disease presenting with only fever and cervical lymphadenopathy at admission .  Journal of Pediatrics156 ( 5 ) 786 - 791   2010年5月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Baba M, Castillo A, Koriyama C, Yanagi M, Matsumoto H, Natsugoe S, Shuyama KY, Khan N, Higashi M, Itoh T, Eizuru Y, Aikou T, Akiba S .  Human papillomavirus is frequently detected in gefitinib-responsive lung adenocarcinomas .  Oncology Reports23 ( 4 ) 1085 - 1092   2010年4月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Koriyama C, Akiba S, Shimaoka S, Itoh T, Akiyama S, Eizuru Y. .  Frequent expression of thymidine phosphorylase in Epstein-Barr virus-associated gastric carcinoma of diffuse-type .  Anticancer Research30   2431 - 2438   2010年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Khan NA, Castillo A, Koriyama C, Kijima Y, Umekita Y, Ohi Y, Higashi M, Sagara Y, Yoshinaka H, Tsuji T, Natsugoe S, Douchi T, Eizuru Y, Akiba S .  Human papillomavirus detected in female breast carcinomas in Japan .  British Journal of Cancer99 ( 3 ) 408 - 414   2008年3月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Campos F.I., Koriyama C., Akiba S., Carrasquilla G., Serra M., Carrascal E., Yamamoto M., Nakano A. .  Toenail zinc level and Gastric Cancer Risk in Cali, Colombia .  Journal of Cancer Research and Clinical Oncology134 ( 2 ) 169 - 178   2008年2月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Koriyama C, Campos FI, Yamamoto M, Serra M, Carrasquilla G, Carrascal E, Akiba S .  Toenail selenium levels and gastric cancer risk in Cali, Colombia .  Journal of Toxicological Sciences33 ( 2 ) 227 - 235   2008年2月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Koriyama C., Akiba S., Itoh T., Sueyoshi K., Minakami Y., Corvalan A., Yonezawa S., Eizuru Y. .  E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance .  World Journal of Gastroenterology13 ( 29 ) 3925 - 3931   2007年8月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Aguayo F., Castillo A., Koriyama C., Higashi M., Itoh T., Capetillo M., Shuyama K., Corvalan A., Eizuru Y., Akiba S. .  Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile .  British Journal of Cancer97 ( 1 ) 85 - 91   2007年7月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Cabrera ME,栄鶴義人(EIZURUYOSHITO),郡山千早(KORIYAMACHIHAYA),秋葉澄伯 .  Nasal NK/T-cell lymphoma and its association with type i / XhoI loss strain Epstein-Barr virus in Chile. .  J Clin Pathol.   2006年6月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Corvalan A,郡山千早(KORIYAMACHIHAYA),栄鶴義人(EIZURUYOSHITO),秋葉澄伯 .  Assoiation of a distinctive strain of Epstein-Barr virus with gastric cancer. .  Int. J. Cancer118 ( 7 ) 1736 - 1742   2006年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Francia C,郡山千早(KORIYAMA CHIHAYA),秋葉澄伯(AKIBASUMINORI),栄鶴義人(EIZURU YOSHITO) .  Environmental factors related to Gastric ancer Associated with Epstein-Barr Virus in Colombia. .  Asian pacific Journal of Cancer Prevention7   633 - 637   2006年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Francia C,郡山千早(KORIYAMA CHIHAYA),秋葉澄伯(AKIBA SUMINORI) .  Risk factors of gastric cancer specific for tumor location and hisstology in Cali, Colombia. .  World J Gastroenterol12 ( 36 ) 5772 - 5779   2006年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Castillo A,郡山千早(KORIYAMACHIHAYA),栄鶴義人(EIZURUYOSHITO),秋葉澄伯 .  Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile. .  WJG12 ( 38 ) 6188 - 6192   2006年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Herrera-Goepfert R,秋葉澄伯,郡山千早(KORIYAMACHIHAYA),栄鶴義人(EIZURUYOSHITO) .  Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population. .  World J Gastroenterol11 ( 39 ) 6096 - 6103   2005年10月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 郡山千早(KORIYAMACHIHAYA),秋葉澄伯,栄鶴義人(EIZURUYOSHITO) .  Environmental Factors Related to Epstein-Barr Virus-Associated Gastric Cancer in Japan. .  J. Exp. Clin. Cancer Res24 ( 4 ) 547 - 553   2005年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Yoshiwara E,郡山千早(KORIYAMACHIHAYA),秋葉澄伯,栄鶴義人(EIZURUYOSHITO) .  Epstein-Barr Virus-associated Gastric Carcinoma in Lima,Peru. .  Journal of Experimental & Clinical Cancer Reserch24 ( 1 ) 49 - 54   2005年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 郡山千早(KORIYAMACHIHAYA),北島信一,野元三治(NomotoMitsuharu),栄鶴義人(EIZURUYOSHITO),米澤傑,秋葉澄伯 .  Loss of p16/CDKN2A Protein in Epstein-Barr Virus-Associated Gastric Carcinoma. .  Oncology67 ( 1 ) 81 - 87   2004年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 郡山千早(KORIYAMACHIHAYA),秋葉澄伯,栄鶴義人(EIZURUYOSHITO) .  Histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma in Japan. .  Oncology Reports12 ( 3 ) 543 - 547   2004年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Morewaya J,郡山千早(KORIYAMACHIHAYA),秋葉澄伯,栄鶴義人(EIZURUYOSHITO) .  Epstein-Barr virus-associated gastric carcinoma in Papua New Guinea. .  Oncology Report12 ( 5 ) 1093 - 1098   2004年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Sonoda J,郡山千早(KORIYAMACHIHAYA),藤吉利信,吉永光裕,永田行博,秋葉澄伯,嶽﨑俊郎(TakezakiToshiro),山田勝士 .  HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking. .  Cancer Sci95 ( 7 ) 596 - 601   2004年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Carrascal E,郡山千早(KORIYAMACHIHAYA),秋葉澄伯,栄鶴義人(EIZURUYOSHITO) .  Epstein-Barr virus-associated gastric carcinoma in Cali,Colombia. .  ONCOLOGY REPORTS10 ( 4 ) 1059 - 1062   2003年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 郡山千早(KORIYAMACHIHAYA),秋葉澄伯,喜島祐子(KijimaYuko),栄鶴義人(EIZURUYOSHITO) .  Prognostic significance of Epstein-Barr virus involvement in gastric carcinoma in Japan. .  International Journal of Molecular Medicine10 ( 5 ) 635 - 639   2002年1月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Yoshinaga M,郡山千早 .  Who is becoming overweight during the elementary school years?. .  International Journal of Obesity26   1 - 6   2002年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 喜島祐子(KijimaYuko),郡山千早(KORIYAMACHIHAYA),秋葉澄伯(AKIBASUMINORI),栄鶴義人,愛甲孝 .  Amplification and overexpressionof c-met gene in Epstein-Barr virus-associated gastric carcinomas .  Oncology62   60 - 65   2002年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Hao Z,郡山千早(KORIYAMACHIHAYA),秋葉澄伯,栄鶴義人(EIZURUYOSHITO) .  The Epstein-Barr virus-associated gastric carcinoma in Southern and Northern China. .  Oncology Reports9 ( 6 ) 1293 - 1298   2002年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Kattoor J,郡山千早(KORIYAMACHIHAYA),秋葉澄伯,栄鶴義人(EIZURUYOSHITO) .  Epstein-Barr Virus-Associated Gastric Carcinoma in Southern India: A Comparison With a Large-Scale Japanese Series. .  Journal of Medical Virology68 ( 3 ) 384 - 389   2002年査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • Corvalan A,郡山千早(KORIYAMACHIHAYA),秋葉澄伯,栄鶴義人(EIZURUYOSHITO) .  Epstein-Barr virus in gastric carcinoma is associated with location in the CARDIA and with a diffuse histology: A study in one area of CHILE. .  Int.J.Cancer94 ( 4 ) 527 - 530   2001年11月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 郡山千早(KORIYAMACHIHAYA),秋葉澄伯,栄鶴義人(EIZURUYOSHITO),愛甲孝 .  Epstein-Barr Virus-associated Gastric Carcinoma in Japanese Brazilians and Non-Japanese Brazilians in S&atilde;o Paulo. .  Japanese Journal of Cancer Reserch92 ( 2 ) 911 - 917   2001年9月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  • 郡山千早(KORIYAMACHIHAYA),藤吉利信,栄鶴義人(EIZURUYOSHITO) .  Human leukocyte antigens related to Epstein-Barr virus-associated gastric carcinoma in Japanese patients. .  European Journal of Cancer Prevention10 ( 1 ) 69 - 75   2001年2月査読

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

▼全件表示

書籍等出版物

  • A mother’s work is to worry: Accepting maternal concerns during a health crisis

    Goto A., Suzuki K., Koriyama C.( 担当: 共著)

    Health Effects of the Fukushima Nuclear Disaster  2022年1月  ( ISBN:9780128240991

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    記述言語:英語

    Natural and technical disasters significantly impact human life cycles starting from reproduction through child rearing. Mothers of young children have been identified as one of the groups at the greatest risk of negative mental health consequences. At the same time, it has been suggested that a life-threatening event, depending on its severity, could motivate people to make positive life decisions. This presentation reviews mothers’ reproductive intention, parenting concerns, and support provided to them to explore the resiliency of their reactions after the Fukushima nuclear accident. I further test the hypothesis of maternal concern as a motivator for health promotion behaviors using data collected during the ongoing COVID-19 pandemic. The single most important clinical implication drawn from the data is that when facing a health crisis, healthcare providers do well to maintain positive receptive attitudes toward mothers expressing concerns and to seek common ground to turn these concerns into positive preventive actions.

    DOI: 10.1016/B978-0-12-824098-4.00010-6

    Scopus

MISC

  • フレイル予防と栄養

    改元 香, 山下 三香子, 鈴木 太朗, 牧迫 飛雄馬, 郡山 千早, 窪薗 琢郎, 竹中 俊宏, 大石 充, 叶内 宏明

    New Diet Therapy   36 ( 3 )   59 - 66   2020年12月

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    出版者・発行元:(一社)日本臨床栄養協会  

  • 賛否の分かれる公衆衛生対策に関するディベート 日本公衆衛生学会モニタリング・レポート委員会による聴衆参加型シンポジウム

    後藤 あや, 尾崎 米厚, 伊藤 慎也, 郡山 千早, 坂野 晶司, 鈴木 貞夫, 鈴木 友理子, 高橋 美保子, 田中 耕, 横川 博英, 吉田 都美, 吉村 健清, 弓屋 結

    日本公衆衛生雑誌   66 ( 8 )   391 - 396   2019年8月

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    出版者・発行元:日本公衆衛生学会  

    目的 健康リスクに関する情報収集を目的として日本公衆衛生学会が設置したモニタリング・レポート委員会(MR委員会)の11グループのうち、「疫学・保健医療情報、保健行動・健康教育」グループが収集したトピックを学会総会で聴衆参加型シンポジウムとして公表した。本報告は公衆衛生課題のモニタリングと人材育成の具体案を提示すべく、シンポジウム実施までの経過とその成果を報告する。方法 年間通じて注目すべきトピックを、インターネットの無料ツール(掲示板とメッセージサービス)を用いてメンバーが収集した。投稿されたトピックの中から、委員会の年度報告書で取り上げたいものを無料日程調整ツールにより多数決で決定した。活動内容 計14トピックについて報告書にまとめ、2017年と2018年に6つのトピック(健康ゴールド免許、医師の強制勤務、電子タバコ、新型たばこ、ヘルステック、糖質制限)をシンポジウムで公表した。各々の反対者と賛成者を設定してそれぞれの根拠を立論した後、聴衆と意見交換を行い、賛成・反対のどちらを支持する人が多いか概数を比較して、最後に講評を行った。全体討論では、政策の公平性、健康格差への影響、生活の質などに関する意見が述べられた。結論 MR委員会のグループとして、インターネットのツールを活用することにより、効率よく情報を収集して蓄積し、共有することができた。聴衆参加型シンポジウムでは、アクティブラーニングに沿った手法を用いて、最新の様々なトピックに共通する課題について議論ができた。(著者抄録)

講演・口頭発表等

  • Bakri Saekhol, Muniroh Muflihatul, Gumay Ainun R., Dewantiningrum Julian, Birawa Ariawan D., Mulyono Mulyono, Nugraheni Arwinda, Mastuyama Rika, Athira Nandakumar, Tanoue Shiroh, Yamamoto Megumi, Koriyama Chihaya .  インドネシア人集団における出生前水銀曝露と出生転帰および成長発達との関連性(Prenatal Mercury Exposure Associated Birth Outcome and Growth Development in Indonesian Cohort) .  Journal of Epidemiology  2023年2月  (一社)日本疫学会

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    記述言語:英語  

  • 渋谷 謙一, 指宿 りえ, 高間 辰雄, 新山 修平, 垣花 泰之, 田ノ上 史郎, 郡山 千早, 嶽崎 俊郎 .  一般住民における血清蛋白値と死亡リスクに関する前向き研究 J-MICC研究 .  Journal of Epidemiology  2023年2月  (一社)日本疫学会

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    記述言語:日本語  

  • 改元 香, 牧迫 飛雄馬, 真邉 久美, 今村 佳代子, 山下 三香子, 油田 幸子, 郡山 千早, 竹中 俊宏, 窪薗 琢郎, 大石 充, 桑原 晶子, 叶内 宏明 .  地域在住高齢者におけるビタミンK摂取量とうつの関係 垂水研究データを用いた横断研究 .  ビタミン  2023年4月  (公社)日本ビタミン学会

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    記述言語:日本語  

  • Vo Tuan Khoa, Nguyen Thy Khue, Yokokawa Hirohide, Goto Aya, Koriyama Chihaya, Naito Toshio .  糖尿病に関するHealth Literacy Score-14の翻訳と検証 ベトナム語版(Translation and validation of the Health Literacy Score-14 for diabetes: the Vietnamese version) .  Journal of Epidemiology  2023年2月  (一社)日本疫学会

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    記述言語:英語  

  • Nandakumar Athira, Koriyama Chihaya, Akiba Suminori .  自然放射線とCAVIおよび頸動脈内膜中膜肥厚度との関連性 インドでの研究(Natural radiation and associated CAVI and Intima-Media Thickness of Carotid Artery-Indian Study) .  Journal of Epidemiology  2023年2月  (一社)日本疫学会

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    記述言語:英語  

  • 改元 香, 叶内 宏明, 油田 幸子, 眞邉 久美, 今村 佳代子, 郡山 千早, 赤崎 雄一, 窪薗 琢郎, 宮田 昌明, 大石 充 .  酢の物摂取習慣と血圧の関係 垂水研究データを用いた横断研究 .  日本循環器病予防学会誌  2023年5月  (一社)日本循環器病予防学会

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    記述言語:日本語  

  • Kamada Hiroyuki, Tokushige Akihiro, Ichiki Hitoshi, Yoshimoto Issei, Ninomiya Yuichi, Iriki Yasuhisa, Koriyama Chihaya, Yonemoto Naohiro, Tahara Yoshio, Ikeda Takanori, Ohishi Mitsuru .  Influence of Active Volcano on Out-of-hospital Cardiac Arrests in Kagoshima: The All-Japan Utstein Registry: JCS-ReSS(タイトル和訳中) .  日本循環器学会学術集会抄録集  2023年3月  (一社)日本循環器学会

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    記述言語:英語  

  • 出雲 公子, 山元 恵, 小松 正治, 郡山 千早, 堀内 正久, 坂本 峰至 .  魚類の鰓を利用した市販魚の筋肉中総水銀濃度の推定 カサゴでの検討 .  日本衛生学雑誌  2019年2月  (一社)日本衛生学会

  • 谷山 祐香里, 伊藤 秀美, 岩崎 基, 郡山 千早, 津金 昌一郎, 大野 ゆう子, 松尾 恵太郎 .  日本人女性の乳がんリスク層別生涯累積罹患リスク推計 .  日本癌学会総会記事  2017年9月  (一社)日本癌学会

  • 伊藤 秀美, 岩崎 基, 郡山 千早, 谷山 祐香里, 尾瀬 功, 井本 逸勢, 大野 ゆう子, 津金 昌一郎, 岩田 広治, 松尾 恵太郎 .  日本人女性における乳がん感受性遺伝子多型による乳がんリスク予測 .  日本癌学会総会記事  2017年9月  (一社)日本癌学会

  • 鈴木 孝太, 若山 怜, 後藤 あや, 郡山 千早 .  新型コロナウイルス感染症(COVID-19)に対する一般市民の意識と行動変容 .  日本公衆衛生学会総会抄録集  2020年10月  日本公衆衛生学会

  • 郡山 千早 .  就寝時の消灯習慣と乳がん発症リスクについて .  日本公衆衛生学会総会抄録集  2020年10月  日本公衆衛生学会

  • Aryal Bibek, Shimizu Toshiaki, Kadono Jun, Furoi Akira, Gejima Kentaro, Komokata Teruo, Koriyama Chihaya, Yamakuchi Munekazu, Hashiguchi Teruto, Imoto Yutaka .  周術期血清中PDGF-BB濃度により切除後HCC再発患者を明らかにする(Perioperative Serum PDGF-BB Concentrations Characterize Patients with Post- Resection HCC Recurrence) .  日本肝胆膵外科学会・学術集会プログラム・抄録集  2018年6月  (一社)日本肝胆膵外科学会

  • 郡山 千早 .  乳癌患者における血清27-hydroxycholesterolレベルの検討(Serum level of 27-hydroxycholesterol in Japanese breast cancer patients) .  日本癌学会総会記事  2019年9月  (一社)日本癌学会

  • 郡山 千早, 伊藤 秀美, 松尾 恵太郎, 秋葉 澄伯 .  乳がんにおける喫煙習慣とSLC4A7遺伝子多型の相互作用 鹿児島における症例対照研究 .  日本癌学会総会記事  2017年9月  (一社)日本癌学会

  • 若山 怜, 後藤 あや, 郡山 千早, 鈴木 孝太 .  一般市民における新型コロナウイルス感染症(COVID-19)の情報収集に関する基礎的検討 .  日本公衆衛生学会総会抄録集  2020年10月  日本公衆衛生学会

  • 郡山 千早 .  ボタンボウフウ摂取による健康影響に関する介入研究 .  日本公衆衛生学会総会抄録集  2019年10月  日本公衆衛生学会

  • 四元 大輔, 山口 美樹, 田中 眞紀, 山口 倫, 鈴木 真彦, 郡山 千早, 大井 恭代, 佐藤 睦, 川野 純子, 寺岡 恵, 木谷 哲, 金光 秀一, 馬場 信一, 相良 吉昭, 松山 義人, 相良 吉厚, 雷 哲明, 相良 安昭 .  センチネルリンパ節生検における残された課題の解決に向けて OSNA法における乳癌センチネルリンパ節転移陽性症例に対する郭清省略についての検討 .  日本外科学会定期学術集会抄録集  2018年4月  (一社)日本外科学会

  • アリアル・ビベック , 清水 利昭, 門野 潤, 風呂井 彰, 槐島 健太郎, 菰方 輝夫, 郡山 千早, 山口 宗一, 橋口 照人, 井本 浩 .  PDGF-BB低値はHCC切除後再発のリスク因子なのか、単なる指標なのか?(Depleted PDGF-BB Kinetic In Post-Resection HCC Recurrence: A Risk Factor or Merely an Indicator?) .  臨床病理  2018年10月  (一社)日本臨床検査医学会

  • 鎌田 博之, 徳重 明央, 市來 仁志, 吉元 一成, 二宮 雄一, 入來 泰久, 郡山 千早, 大石 充 .  鹿児島県のウツタインデータを用いた活火山の降灰が院外心停止に及ぼす影響の検討:The All-Japan Utstein Registry .  日本循環器病予防学会誌  2022年5月  (一社)日本循環器病予防学会

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  • 松山 吏香, Bakri Saekhol, Nandakumar Athira, 堀内 正久, 郡山 千早 .  鹿児島大学医療従事者を対象とした新型コロナウイルス血清抗体の分布 .  Journal of Epidemiology  2022年1月  (一社)日本疫学会

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    記述言語:日本語  

  • 若山 怜, 後藤 あや, 郡山 千早, 鈴木 孝太 .  新型コロナウイルス感染症(COVID-19)流行前のインフルエンザワクチン接種に関する要因の検討 .  Journal of Epidemiology  2022年1月  (一社)日本疫学会

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  • 黒田 佑次郎, 後藤 あや, 郡山 千早, 鈴木 孝太 .  新型コロナウイルス感染症(COVID-19)流行下における人々の不安とヘルスリテラシーの関連 自由記述の分析 .  Journal of Epidemiology  2021年1月  (一社)日本疫学会

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  • 若山 怜, 後藤 あや, 郡山 千早, 鈴木 孝太 .  新型コロナウイルス感染症(COVID-19)に対する予防行動の変容に関する要因の検討 .  Journal of Epidemiology  2021年1月  (一社)日本疫学会

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  • 玉利 拓磨, Dhruva Athira, 郡山 千早, 喜島 祐子, 金子 朋代 .  就寝時の消灯習慣と乳がん発症リスクの検討 .  Journal of Epidemiology  2021年1月  (一社)日本疫学会

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  • 若山 怜, 後藤 あや, 郡山 千早, 鈴木 孝太 .  子どもと同居する親の、喫煙と予防行動の関連 .  日本小児禁煙研究会雑誌  2022年3月  (NPO)日本小児禁煙研究会

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  • 郡山 千早, 鈴木 孝太, 後藤 あや .  医学生におけるCOVID-19への不安やヘルスリテラシーと行動変容について .  日本公衆衛生学会総会抄録集  2021年11月  日本公衆衛生学会

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    記述言語:日本語  

  • Bakri Saekhol, Munioh Muflihatul, Gumay Ainun Rahmasari, Dewantiningrum Julian, Mulyono Mulyono, Anantyo Dimas Tri, Hardian Hardian, Yamamoto Megumi, Koriyama Chihaya .  出生時体重と出生前の低濃度水銀曝露との関連 インドネシア、中部ジャワ州スマランでのコホート研究(Association between Birth Weight and Pre-natal Exposure to Low Mercury Level: a Cohort Study in Semarang, Central Java, Indonesia) .  Journal of Epidemiology  2022年1月  (一社)日本疫学会

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  • 兒玉 慎平, 上床 太心, 郡山 千早 .  保健師のマンパワーの変化と標準化死亡比の経験的ベイズ推定量の変化の関係 .  日本公衆衛生学会総会抄録集  2022年9月  日本公衆衛生学会

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  • Nandakumar Athira, Koriyama Chihaya, Akiba Suminori .  インドのKarunagappally, Keralaにおける自然放射線被曝とアテローム性動脈硬化症(Natural radiation exposure and atherosclerosis in Karunagappally, Kerala, India) .  Journal of Epidemiology  2022年1月  (一社)日本疫学会

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  • 郡山 千早, 玉利 拓磨, Bakri Saekhol, Dhruva Athira, 鈴木 孝太, 後藤 あや .  COVID-19に関する大学生の意識や行動変容について .  Journal of Epidemiology  2021年1月  (一社)日本疫学会

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