Updated on 2024/10/08

写真a

 
KUSANO Shuichi
 
Organization
Research Field in ? Associate Professor
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine
Title
Associate Professor

Degree

  • 博士(理学) ( 1996.3   総合研究大学院大学 )

Research Interests

  • 転写制御

  • Phospholipid Scramblase 1

  • HTLV-1

  • HIV-1

  • KSHV

  • EBウイルス

Research Areas

  • Life Science / Molecular biology

  • Life Science / Virology

Education

  • The Graduate University for Advanced Studies

    1993.4 - 1996.3

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    Country: Japan

  • Tokyo University of Science

    1988.4 - 1990.3

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    Country: Japan

  • Tokyo University of Science

    1984.4 - 1988.3

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    Country: Japan

Research History

  • Kagoshima University   Research Field in Integrated Studies, Integrated Arts and Sciences Area ?   Associate Professor

    2019.4

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine

    2006.2

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Health Research Course Infection and Immunity   Associate Professor

    2006.2 - 2019.3

Professional Memberships

  • アメリカ生化学分子生物学会

    2015.10

  • アメリカ微生物学会

    2015.10

  • 日本ウイルス学会

    2015.10

  • 日本分子生物学会

    2015.10

Studying abroad experiences

  • 1997.1 - 2002.3   ノースカロライナ大学 ラインバーガーがん研究所   博士研究員

Qualification acquired

  • Chief Person of Radiation Handling (first and second kind)

 

Papers

  • Hidetaka Sadanari, Masaya Takemoto, Tomoki Ishida, Hikaru Otagiri, Tohru Daikoku, Tsugiya Murayama, Shuichi Kusano .  The Interferon-Inducible Human PLSCR1 Protein Is a Restriction Factor of Human Cytomegalovirus. .  Microbiology spectrum   e0134221   2022.2The Interferon-Inducible Human PLSCR1 Protein Is a Restriction Factor of Human Cytomegalovirus.Reviewed International journal

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/spectrum.01342-21

    PubMed

  • Shuichi Kusano, Masanori Ikeda .  Interaction of phospholipid scramblase 1 with the Epstein-Barr virus protein BZLF1 represses BZLF1-mediated lytic gene transcription. .  Journal of Biological Chemistry294 ( 41 ) 15104 - 15116   2019.10Reviewed International journal

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:ASBMB  

    DOI: 10.1074/jbc.RA119.008193

    Scopus

    PubMed

    Other Link: http://www.jbc.org/content/294/41/15104.long

  • Shuichi Kusano, Makoto Yoshimitsu, Miho Hachiman, Masanori Ikeda .  I-mfa domain proteins specifically interact with HTLV-1 Tax and repress its transactivating functions .  Virology486   219 - 227   2015.9Reviewed International journal

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Virology  

    DOI: 10.1016/j.virol.2015.09.020

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  • Shuichi Kusano, Yoshito Eizuru .  Interaction of the phospholipid scramblase 1 with HIV-1 Tat results in the repression of Tat-dependent transcription .  Biochemical and Biophysical Research Communications433 ( 4 ) 138 - 444   2013.1Interaction of the phospholipid scramblase 1 with HIV-1 Tat results in the repression of Tat-dependent transcriptionReviewed International journal

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Shuichi Kusano, Yoshito Eizuru .  Human phospholipid scramblase 1 interacts with and regulates transactivation of HTLV-1 Tax .  Virology432 ( 2 ) 343 - 352   2012.10Human phospholipid scramblase 1 interacts with and regulates transactivation of HTLV-1 TaxReviewed International journal

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Shuichi Kusano, Yuki Shiimura, Yoshito Eizuru .  I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions. .  Biochimie93 ( 9 ) 1555 - 1564   2011.9I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions.Reviewed International journal

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Shuichi Kusano, Yoshito Eizuru .  Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription. .  Biochemical and Biophysical Research Communications396 ( 3 ) 608 - 613   2010.6Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription.Reviewed International journal

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  • Thornburg NJ, Kusano S, Raab-Traub N .  Identification of Epstein-Barr virus RK-BARF0-interacting proteins and characterization of expression pattern. .  Journal of virology78 ( 23 ) 12848 - 56   2004.12Identification of Epstein-Barr virus RK-BARF0-interacting proteins and characterization of expression pattern.Reviewed International coauthorship International journal

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.78.23.12848-12856.2004

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  • Everly DN Jr, Kusano S, Raab-Traub N .  Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells. .  Journal of virology78 ( 21 ) 11648 - 55   2004.11Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells.Reviewed International coauthorship International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JVI.78.21.11648-11655.2004

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  • Kusano S, Raab-Traub N .  I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. .  Molecular and cellular biology22 ( 18 ) 6393 - 405   2002.9I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.Reviewed International coauthorship International journal

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    DOI: 10.1128/mcb.22.18.6393-6405.2002

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  • Shuichi Kusano,Nancy Raab-Traub .  An Epstein-Barr Virus Protein Interacts with Notch .  Journal of Virology75 ( 1 ) 384 - 395   2001.1An Epstein-Barr Virus Protein Interacts with NotchReviewed International coauthorship International journal

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  • Shuichi Kusano, Quinquan Ding, Nobuyuki Fujita, Akira Ishihama .  Promoter selectivity of Escherichia coli RNA polymerase Eσ70 and Eσ38 holoenzymes:Effect of DNA supercoiling .  J. Biol. Chem.271 ( 4 ) 1998 - 2004   1996.1Promoter selectivity of Escherichia coli RNA polymerase Eσ70 and Eσ38 holoenzymes:Effect of DNA supercoilingReviewed International journal

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Wang Y, Shimosaki S, Ikebe E, Iha H, Yamamoto JI, Fife N, Ichikawa T, Hori M, Ogata M, Tsukamoto Y, Hijiya N, Moriyama M, Hagiwara S, Kusano S, Saito M, Ahmed K, Nishizono A, Handa H, Morishita K .  IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors. .  Frontiers in oncology13   1272528   2023Reviewed International coauthorship

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Frontiers in Oncology  

    Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasia associated with human T-cell leukemia virus type 1 (HTLV-1) infection and has an extremely poor prognosis. Lenalidomide (LEN; a second-generation immunomodulatory drug [IMiD]) has been employed as an additional therapeutic option for ATL since 2017, but its mechanism of action has not been fully proven, and recent studies reported emerging concerns about the development of second primary malignancies in patients treated with long-term IMiD therapy. Our purpose in this study was to elucidate the IMiD-mediated anti-ATL mechanisms. Thirteen ATL-related cell lines were divided into LEN-sensitive or LEN-resistant groups. CRBN knockdown (KD) led to a loss of LEN efficacy and IKZF2-KD-induced LEN efficacy in resistant cells. DNA microarray analysis demonstrated distinct transcriptional alteration after LEN treatment between LEN-sensitive and LEN-resistant ATL cell lines. Oral treatment of LEN for ATL cell-transplanted severe combined immunodeficiency (SCID) mice also indicated clear suppressive effects on tumor growth. Finally, a novel cereblon modulator (CELMoD), iberdomide (IBE), exhibited a broader and deeper spectrum of growth suppression to ATL cells with efficient IKZF2 degradation, which was not observed in other IMiD treatments. Based on these findings, our study strongly supports the novel therapeutic advantages of IBE against aggressive and relapsed ATL.

    DOI: 10.3389/fonc.2023.1272528

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  • Yuichiro Uchida、Makoto Yoshimitsu、Miho Hachiman、 Shuichi Kusano、Naosuke Arima、Kodai Shima、Maiko Hayashida、Yuhei Kamada、Daisuke Nakamura、Akihiko Arai、Yuetsu Tanaka、Hiromitsu Hara、Kenji Ishitsuka .  RLTPR Q575E: A novel recurrent gain-of-function mutation in patients with adult T-cell leukemia/lymphoma .  European Journal of Heamatology106 ( 2 ) 221 - 229   2020.10Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:European Journal of Haematology  

    DOI: 10.1111/ejh.13540

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  • Ueda S, Oishi S, Wang ZX, Araki T, Tamamura H, Cluzeau J, Ohno H, Kusano S, Nakashima H, Trent JO, Peiper SC, Fujii N .  Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities. .  Journal of medicinal chemistry50 ( 2 ) 192 - 8   2007.1Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.Reviewed International coauthorship International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jm0607350

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  • 齋藤 晋,草野秀一,肥塚泉,中島秀喜 .  Epstein-Barr ウイルスLMP1遺伝子導入によるVimentinとEzrinの発現増強 .  日本耳鼻咽喉科学会会報110 ( 1 ) 24 - 31   2007.1Epstein-Barr ウイルスLMP1遺伝子導入によるVimentinとEzrinの発現増強Reviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Satoshi Ueda, Shinya Oishi, Zi-xuan Wang, Takanobu Araki, Hirokazu Tamamura, Jerome Cluzeau, Hiroaki Ohno, Shuichi Kusano, Hideki Nakashima, John O. Trent, Stephen C. Piper, Nobutaka Fujii .  Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities .  J. Med. Chem.50 ( 2 ) 192 - 198   2007.1Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalitiesReviewed

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  • Eda H, Ishii Y, Obayashi M, Harada S, Ito S, Fujita T, Ikeda M, Kusano S, Kitamura R, Suzuki C, Hara T, Watanabe M, Satoh H, Sugihara K, Yanagi K .  Monoclonal antibodies against regions topologically surrounding the homodimeric beta-barrel interface of Epstein-Barr virus nuclear antigen-1. .  Virus research109 ( 1 ) 87 - 94   2005.4Monoclonal antibodies against regions topologically surrounding the homodimeric beta-barrel interface of Epstein-Barr virus nuclear antigen-1.Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.virusres.2004.10.012

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  • Hiroyuki Eda, Yasuyuki Ishii, Maya Obayashi, Shizuko Harada, Sayuri Ito, Tomomichi Fujita, Masato Ikeda, Shuichi Kusano, Ryo Kitamura, Chieko Suzuki, Takahiko Hara, Motoo Watanabe, Hiroshi Satoh, Keisuke Sugihara, Kazuo Yanagi .  Elevated immunoglobulin G antibodies to the proline-rich amino-terminal region of Epstein-Barr virus nuclear antigen-2 in sera from patients with systemic connective tissue diseases and from a subgroup of Sjogren's syndrome with pulmonary involvements .  Clin. Exp. Immunol.139   558 - 568   2005.3Elevated immunoglobulin G antibodies to the proline-rich amino-terminal region of Epstein-Barr virus nuclear antigen-2 in sera from patients with systemic connective tissue diseases and from a subgroup of Sjogren's syndrome with pulmonary involvementsReviewed

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  • Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Zixuan Wang, Shuichi Kusano, Shigemi Terakubo, John O. Trent, Stephen C. Piper, Naoki Yamamoto, Hideki Nakashima, Akira Otaka, Fujii Nobutaka .  Stereoselective Synthesis of [L-Arg, L/D-3-(2-naphtyl)alanine]-Type(E)-Alkene Dipeptide Isosteres and its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogs of the CXCR4 Antagonist FC131 .  J. Med. Chem.48 ( 2 ) 380 - 391   2005.3Stereoselective Synthesis of [L-Arg, L/D-3-(2-naphtyl)alanine]-Type(E)-Alkene Dipeptide Isosteres and its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogs of the CXCR4 Antagonist FC131Reviewed

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  • Tamamura H, Hiramatsu K, Ueda S, Wang Z, Kusano S, Terakubo S, Trent JO, Peiper SC, Yamamoto N, Nakashima H, Otaka A, Fujii N .  Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. .  Journal of medicinal chemistry48 ( 2 ) 380 - 91   2005.1Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131.Reviewed International coauthorship International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jm049429h

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  • Tamamura H, Mizumoto M, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N .  Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides. .  Organic & biomolecular chemistry2 ( 8 ) 1255 - 7   2004.4Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides.Reviewed International coauthorship International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/b401485p

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  • Hidetsugu Wakabayashi, Kana Hashiba, Keiko Yokoyama, Ken Hashimoto, Hirotaka Kikuchi, Hirofumi Nishikawa, Teruo Kurihara, Kazue Satoh, Seiji Shioda, Susumu Saito, Shuichi Kusano, Hideki Nakashima, Noboru Motohashi, Sakagami Hiroshi .  Cytotoxic Activity of Azulenes Against Human Oral Tumor Cell Lines .  Anticancer Res.23 ( 6C ) 4747 - 4755   2003.12Cytotoxic Activity of Azulenes Against Human Oral Tumor Cell LinesReviewed

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  • Tamamura H, Hiramatsu K, Kusano aS, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N .  Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. .  Organic & biomolecular chemistry1 ( 21 ) 3656 - 62   2003.11Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives.Reviewed International coauthorship International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/b306473p

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  • Tamamura H, Hiramatsu K, Mizumoto M, Ueda S, Kusano S, Terakubo S, Akamatsu M, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N .  Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. .  Organic & biomolecular chemistry1 ( 21 ) 3663 - 9   2003.11Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/b306613b

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  • Wakabayashi H, Hashiba K, Yokoyama K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Satoh K, Shioda S, Saito S, Kusano S, Nakashima H, Motohashi N, Sakagami H .  Cytotoxic activity of azulenes against human oral tumor cell lines. .  Anticancer research23 ( 6C ) 4747 - 55   2003.11Cytotoxic activity of azulenes against human oral tumor cell lines.Reviewed International journal

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  • Fujii N, Oishi S, Hiramatsu K, Araki T, Ueda S, Tamamura H, Otaka A, Kusano S, Terakubo S, Nakashima H, Broach JA, Trent JO, Wang ZX, Peiper SC .  Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries. .  Angewandte Chemie (International ed. in English)42 ( 28 ) 3251 - 3   2003.7Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries.Reviewed International coauthorship International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.200351024

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  • Shuichi Kusano, Keiko Tamada, Hidenobu Senpuku, Shizuko Harada, Sayuri Ito, Kazuo Yanagi .  Epstein-Barr Virus Nuclear Antigen-1-Dependent and -Independent oriP-Binding Cellular Proteins .  Intervirology44 ( 5 ) 283 - 290   2001.1Epstein-Barr Virus Nuclear Antigen-1-Dependent and -Independent oriP-Binding Cellular ProteinsReviewed

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  • Tomomichi Fujita, Masato Ikeda, Shuichi Kusano, Makoto Yamazaki, Sayuri Ito, Maya Obayashi, Kazuo Yanagi .  Amino Acid Substitution Analyses of the DNA Contact Region, Two Amphipathic alpha-Helices and a Recognition-Helix-Like Helix outside the Dimeric beta-Barrel of Epstein-Barr Virus Nuclear Antigen 1 .  Intervirology44 ( 5 ) 271 - 282   2001.1Amino Acid Substitution Analyses of the DNA Contact Region, Two Amphipathic alpha-Helices and a Recognition-Helix-Like Helix outside the Dimeric beta-Barrel of Epstein-Barr Virus Nuclear Antigen 1Reviewed

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  • Manuel Ballesteros, Shuichi Kusano, Akira Ishihama,Vincente Miguel .  The ftsQ1p Gearbox Promoter of Escherichia coli Is a Major σS-Depemdent Promoter in the ddlB-ftsA Region .  Mol. Microbiol.30 ( 2 ) 419 - 430   1998.10The ftsQ1p Gearbox Promoter of Escherichia coli Is a Major σS-Depemdent Promoter in the ddlB-ftsA RegionReviewed International coauthorship

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  • Tapas K. Kundu, Shuichi Kusano, Akira Ishihama .  Promoter Selectivity of Escherichia coli RNA Polymerase σF Holoenzyme Involved in Transcription of Flagellar and Chemotaxis genes .  J. Bacteriol.179 ( 13 ) 4264 - 4269   1997.7Promoter Selectivity of Escherichia coli RNA Polymerase σF Holoenzyme Involved in Transcription of Flagellar and Chemotaxis genesReviewed

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  • Shuichi Kusano, Akira Ishihama .  Functional Interaction of Escherichia coli RNA Polymerase with Inorganic Polyphosphate .  Genes Cells2 ( 7 ) 433 - 441   1997.7Functional Interaction of Escherichia coli RNA Polymerase with Inorganic PolyphosphateReviewed

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  • Shuichi Kusano, Akira Ishihama .  Stimulatory Effect of Trehalose on Formation and Activity of Escherichia coli RNA Polymerase Eσ38 Holoenzyme .  J. Bacteriol.179 ( 11 ) 3649 - 3654   1997.6Stimulatory Effect of Trehalose on Formation and Activity of Escherichia coli RNA Polymerase Eσ38 HoloenzymeReviewed

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  • K. Rajkumari, Shuichi Kusano, Akira Ishihama, Takeshi Mizuno, J. Gowrishankar .  Effects of H-NS and potassium glutamate on sigmaS- and sigma70-directed transcription in vitro from osmotically regulated P1 and P2 promoters of proU in Escherichia coli .  J. Bacteriol.178 ( 14 ) 4176 - 4181   1996.7Effects of H-NS and potassium glutamate on sigmaS- and sigma70-directed transcription in vitro from osmotically regulated P1 and P2 promoters of proU in Escherichia coliReviewed International coauthorship

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  • Qingquan Ding, Shuichi Kusano, Merna Villarejo, Akira Ishihama .  Promoter selectivity of Escherichia coli RNA polymerase by ionic strength: differential recognition of osmoregulated promoters by EσD and EσS holoenzymes .    16 ( 4 ) 649 - 656   1995.5Promoter selectivity of Escherichia coli RNA polymerase by ionic strength: differential recognition of osmoregulated promoters by EσD and EσS holoenzymesReviewed

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  • Annie Kolb, Denise Kotlarz, Shuichi Kusano, Akira Ishihama .  Selectivity of Escherichia coli RNA polymerase Eσ38 for overlapping promoters and ability to support CRP activation .  Nucleic Acids Res.23 ( 5 ) 819 - 826   1995.3Selectivity of Escherichia coli RNA polymerase Eσ38 for overlapping promoters and ability to support CRP activationReviewed International coauthorship

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  • Kan Tanaka, Shuichi Kusano, Nobuyuki Fujita, Akira Ishihama, Hideo Takahashi .  Promoter determinants for Escherichia coli RNA polymerase holoenzyme containing sigma38 (the rpoS gene product) .  Nucleic Acids Res.23 ( 5 ) 827 - 834   1995.3Promoter determinants for Escherichia coli RNA polymerase holoenzyme containing sigma38 (the rpoS gene product)Reviewed

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Books

  • BARTs, BARF1,「EBウイルス(高田賢蔵監修)」

    草野秀一( Role: Sole author)

    診断と治療社  2008.8 

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    Language:Japanese Book type:Scholarly book

  • Tat遺伝子、「KEY WORD感染症(山口惠三、戸塚恭一 編集)」

    草野秀一( Role: Sole author)

    先端医学社  2008.8 

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    Language:Japanese Book type:Scholarly book

  • BARTs、BARF1、「EBウイルス(高田賢蔵監修)」

    草野秀一( Role: Sole author)

    診断と治療社  2003.7 

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    Language:Japanese Book type:Scholarly book

  • 生きるための遺伝戦略、ネオ生物学シリーズ「細菌(吉川 寛編)」

    石濱明,草野秀一( Role: Joint author)

    共立出版  1996.12 

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    Language:Japanese Book type:Scholarly book

Presentations

  • Kusano S., Ikeda M.   PLSCR1 specifically interacts with EBV lytic-transactivator BZLF1 and represses its transcriptional activity in EBV-infected nasopharyngeal carcinoma cell line.  

    2017年度生命科学系学会合同年次大会(ConBio2017) 

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

    Venue:神戸  

  • Kusano Shuichi, Ikeda Masanori   Interaction of the PLSCR1 with Epstein-Barr virus BZLF1 results in the repression of BZLF1-mediated lytic transcription  

    第66回日本ウイルス学会学術集会  日本ウイルス学会

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    Event date: 2018.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都  

  • 9. 草野 秀一、池田正徳   PLSCR1はEBウイルス感染上咽頭がん細胞株においてEBウイルス転写因子BZLF1と相互作用しその転写活性化を抑制する  

    生命科学系学会合同年次大会 

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    Event date: 2017.12

    Language:English   Presentation type:Poster presentation  

    Venue:神戸  

  • 草野秀一、池田正徳   Phospholipid Scramblase 1はEBウイルスBZLF1と相互作用しその機能を抑制する  

    第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸  

  • Shuichi Kusano, Masanori Ikeda   I-mfa Domain Proteins Specifically Interact with HTLV-1 Tax and Repress Its Transactivating Functions  

    第63回日本ウイルス学会学術集会 

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    Event date: 2015.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡  

  • 草野秀一、池田正徳   I-mfaドメインタンパク質HICはHTLV-1 Taxと相互作用しその機能を抑制する  

    第2回HTLV-1学会 

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    Event date: 2015.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京  

  • Shuichi Kusano, Yoshito Eizuru   Human Phospholipid Scramblase 1 Specifically Interacts with HTLV-1 Tax and Affects Its Transcriptional Activities.   International conference

    International Union of Microbiological Societies 2011  International Union of Microbiological Societies 2011

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    Event date: 2011.9

    Language:English  

    Venue:Sapporo  

    国際学会

  • Shuichi Kusano, Yusuke Sameshima, Yoshito Eizuru   I-mfa domain proteins specifically interact with KSHV LANA and modulate its regulation of Wnt signaling pathway   International conference

    The 14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections  The 14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections

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    Event date: 2009.10

    Language:English  

    Venue:Kobe  

    国際学会

  • 草野秀一、椎村祐樹、栄鶴義人   Phospholipid Scramblase 1はHIV-1 Tatと相互作用しTatによる転写を制御する。  

    第30回日本分子生物学会年会・第80回日本生化学会大会合同年会 ワークショップ「ウイルス研究から明らかになった宿主因子の新たな機能」  第30回日本分子生物学会年会・第80回日本生化学会大会合同年会 ワークショップ「ウイルス研究から明らかになった宿主因子の新たな機能」

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    Event date: 2007.12

    Language:Japanese  

    Venue:横浜  

    国内学会

  • Shuichi Kusano, Yoshito Eizuru   HUMAN I-MFA-DOMAIN-CONTAINING PROTEINS INTERACT WITH KSHV LANA AND MODULATES ITS REGULATION OF WNT SIGNALING PATHWAY   International conference

    The 32nd INTERNATIONAL HERPESVIRUS WORKSHOP  The 32nd INTERNATIONAL HERPESVIRUS WORKSHOP

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    Event date: 2007.7

    Language:English  

    Venue:Asheville, USA  

    国際学会

  • 草野秀一、栄鶴義人   I-mfaドメインタンパク質はKSHV LANAタンパク質によるWntシグナルの促進を抑制する  

    第22回ヘルペスウイルス研究会  第22回ヘルペスウイルス研究会

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    Event date: 2007.6

    Language:Japanese  

    Venue:日本  

    研究会

  • 草野秀一,栄鶴義人   I-mfaドメインタンパク質はKSHV LANAタンパク質によるWntシグナルの促進を抑制する  

    第4回EBウイルス研究会  第4回EBウイルス研究会

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    Event date: 2007.6

    Language:Japanese  

    Venue:日本  

    研究会

  • 草野秀一,栄鶴義人   I-mfaドメインタンパク質はカポジ肉腫関連ヘルペスウイルスLANAタンパク質によるWntシグナルの促進を抑制する  

    第54回日本ウイルス学会学術集会  第54回日本ウイルス学会学術集会

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    Event date: 2006.11

    Language:Japanese  

    Venue:日本  

    国内学会

  • Shuichi Kusano   I-mfa Domain Proteins Interact with KSHV LANA and Modulate Its Regulation of Wnt Signaling Pathway   International conference

    The 30th International Herpesvirus Workshop  The 30th International Herpesvirus Workshop

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    Event date: 2005.7

    Language:English  

    Venue:Finland  

    国際学会

  • 草野秀一,Raab-Traub Nancy   EBウイルスRK-BARF0タンパク質はI-mfaによるWntシグナルの抑制を解除する  

    第27回日本分子生物学会年会、ワークショップ「感染症と発がんのミッシング・リンク」  第27回日本分子生物学会年会、ワークショップ「感染症と発がんのミッシング・リンク」

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    Event date: 2004.12

    Language:Japanese  

    Venue:神戸  

    国内学会

  • Shuichi Kusano,Nancy Raab-Traub   Epstein-Barr Virus RK-BARF0 Protein Inhibits I-mfa-mediated repression of Wnt Signaling Pathway by Disruption of I-mfa-TDF/LEF-1 Complex Formation   International conference

    The 11th International Meeting on the EBV Association  The 11th International Meeting on the EBV Association

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    Event date: 2004.9

    Language:English  

    Venue:Germany  

    国際学会

  • Shuichi Kusano, Susum Saito   HIV Tat Specifically Interacts with Notch Proteins in vivo.   International conference

    The 3rd Awaji International Forum on Infection and Immunity  The 3rd Awaji International Forum on Infection and Immunity

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    Event date: 2003.8

    Language:English  

    Venue:Japan  

    国際学会

  • Nancy Raab-Traub, Shuichi Kusano   The Epstein Barr Virus RK-BARF0 Induces Degradation of Specific Interacting Cellular Proteins   International conference

    The 10th International Meeting on the EBV Association  The 10th International Meeting on the EBV Association

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    Event date: 2002.7

    Language:English  

    Venue:Australia  

    国際学会

  • Shuichi Kusano,Nancy Raab-Traub   EBV RK-BARF0 Targets Several Cellular Signaling Pathways through Direct Interactions   International conference

    The 10th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections  The 10th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections

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    Event date: 2001.11

    Language:English  

    Venue:Japan  

    国際学会

  • Shuichi Kusano,Nancy Raab-Traub   Epstein-Barr Virus RK-BARF0 Protein Specifically Interacts with Notch Protein in Vivo   International conference

    The 25th International Herpesvirus Workshop  The 25th International Herpesvirus Workshop

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    Event date: 2000.7

    Language:English  

    Venue:USA  

    国際学会

  • 草野秀一,藤田信之,石浜 明   大腸菌RNAポリメラーゼの増殖期主要σサブユニット(σD)及び定常期特異的σサブユニット(σS)の機能比較  

    第18回日本分子分子生物学会年会 

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    Event date: 1998.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋  

  • Shuichi Kusano,Nancy Raab-Traub   RK-BARF0 protein specifically interacts with NOTCH4 protein in vivo through the predicted hydrophobic helix region   International conference

    The 8th International Meeting of the EBV Association  The 8th International Meeting of the EBV Association

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    Event date: 1998.6

    Language:English  

    Venue:Sweden  

    国際学会

  • 草野秀一,藤田信之,石浜 明   大腸菌RNAポリメラーゼの増殖期主要σサブユニット(σD)及び定常期特異的σサブユニット(σS)の機能比較  

    第17回日本分子分子生物学会年会 

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    Event date: 1994.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸  

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Research Projects

  • PLSCR1の262番アミノ酸の変異は、なぜCOVID-19の重症化に関与するのか?

    2023.4 - 2026.3

    科学研究費補助金  基盤研究(c)

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    Grant type:Competitive

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

  • HTLV-1タンパク質によるHIF-1αを標的とした感染細胞制御機構の解析

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

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    Grant type:Competitive

    本研究では、ヒトT細胞白血病ウイルス(HTLV)-1による発がんに重要な役割を演じているウイルスタンパク質であるTax及びHBZが、直接的或いは間接的な相互作用を介して宿主細胞増殖を制御する転写因子である低酸素誘導因子(HIF)-1αの機能に及ぼす影響を分子生物学・生化学的手法を用いて詳細に解析する。
    そして、その結果から、これらのHTLV-1タンパク質がHIF-1αの機能をどのように制御し、ウイルス感染維持や細胞のがん化の促進に関与するのかを明らかにしたいと考えている

  • EBウイルスRK-BARF0の機能解析

    2002.4 - 2003.3

    上原記念生命科学財団  上原記念生命科学財団研究奨励金  

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    Authorship:Principal investigator  Grant type:Competitive

    EBウイルスRK-BARF0の機能解析

 

Social Activities

  • 平成28年度教員免許状更新講習

    Role(s): Lecturer

    2016.8

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    Audience: Teachers

  • 平成28年度教員免許状更新講習

    2016.8

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    Audience: Teachers

  • 平成27年度教員免許状更新講習

    Role(s): Lecturer

    2015.8

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    Audience: Teachers

  • 平成27年度教員免許状更新講習

    Role(s): Lecturer

    2015.8

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    Audience: Teachers