Updated on 2024/05/15

写真a

 
HASHIMOTO Masahito
 
Organization
Research Field in Engineering, Science and Engineering Area Graduate School of Science and Engineering (Engineering) Department of Engineering Chemistry and Biotechnology Program Professor
Title
Professor
Contact information
メールアドレス

Degree

  • 博士(理学) ( 1997.6   大阪大学 )

  • 修士(理学) ( 1994.3   神戸大学 )

  • 学士(理学) ( 1992.3   神戸大学 )

Research Interests

  • 植物免疫

  • 自然免疫

  • 感染症

  • 細菌

  • NMR

  • 分子間相互作用

  • 生物活性

  • 機能解析

  • 構造

  • 複合糖質

Research Areas

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

  • Life Science / Bacteriology

  • Nanotechnology/Materials / Polymer chemistry

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

  • Life Science / Immunology

  • Life Science / Bioorganic chemistry

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Education

  • Osaka University

    1994.4 - 1997.6

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    Country: Japan

  • Kobe University

    1992.4 - 1994.3

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    Country: Japan

  • Kobe University

    1988.4 - 1992.3

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    Country: Japan

Research History

  • Kagoshima University   Research Field in Engineering, Science and Engineering Area Graduate School of Science and Engineering (Engineering) Department of Engineering Chemistry and Biotechnology Program   Professor

    2020.4

  • Kagoshima University   Research Field in Engineering, Science and Engineering Area Graduate School of Science and Engineering (Engineering) Chemistry, Biotechnology, and Chemical Engineering Course   Professor

    2014.5 - 2020.3

  • Kagoshima University   Associate Professor

    2004.4 - 2014.4

  • Asahi University   Research Assistant

    2001.4 - 2004.3

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    Country:Japan

  • ヒューマンサイエンス振興財団(国立国際医療センター)   リサーチレジデント

    2000.10 - 2001.3

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    Country:Japan

  • 国立国際医療センター   研究所   流動研究員

    2000.4 - 2000.9

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    Country:Japan

  • 学術振興会(大阪大学)   特別研究員

    1997.4 - 2000.3

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    Country:Japan

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Professional Memberships

  • 日本生物工学会

    2017.4

  • 日本糖質学会

    2006.1

  • 日本分子生物学会

    2002.1

  • 日本細菌学会

    2001.1

  • 日本免疫学会

    2000.11

  • 日本生化学会

    1996.10

  • 日本化学会

    1992.10

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Papers

  • Sakuma M., Hashimoto M., Nishi K., Tohya M., Hishinuma T., Shimojima M., Tada T., Kirikae T. .  Emergence of colistin-resistant Acinetobacter modestus harbouring the intrinsic phosphoethanolamine transferase EptA .  Journal of Global Antimicrobial Resistance33   101 - 108   2023.6

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    Language:Japanese   Publisher:Journal of Global Antimicrobial Resistance  

    Objectives: Colistin-resistant Gram-negative pathogens have become a serious worldwide medical problem. This study was designed to reveal the effects of an intrinsic phosphoethanolamine transferase from Acinetobacter modestus on Enterobacterales. Methods: A strain of colistin-resistant A. modestus was isolated from a sample of nasal secretions taken in 2019 from a hospitalised pet cat in Japan. The whole genome was sequenced by next generation sequencing, and transformants of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae harbouring the phosphoethanolamine transferase–encoding gene from A. modestus were constructed. Lipid A modification in E. coli transformants was analysed using electrospray ionization mass spectrometry. Results: Sequencing of the entire genome revealed that the isolate harboured a phosphoethanolamine transferase–encoding gene, eptA_AM, on its chromosome. Transformants of E. coli, K. pneumoniae, and E. cloacae harbouring both the promoter and eptA_AM gene from A. modestus had 32-fold, 8-fold, and 4-fold higher minimum inhibitory concentrations (MICs) for colistin, respectively, than transformants harbouring a control vector. The genetic environment surrounding eptA_AM in A. modestus was similar to that surrounding eptA_AM in Acinetobacter junii and Acinetobacter venetianus. Electrospray ionization mass spectrometry analysis revealed that EptA_AM modified lipid A in Enterobacterales. Conclusion: This is the first report to describe the isolation of an A. modestus strain in Japan and show that its intrinsic phosphoethanolamine transferase, EptA_AM, contributes to colistin resistance in Enterobacterales and A. modestus.

    DOI: 10.1016/j.jgar.2023.02.023

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  • Tateo S., Shinchi H., Matsumoto H., Nagata N., Hashimoto M., Wakao M., Suda Y. .  Optimized immobilization of single chain variable fragment antibody onto non-toxic fluorescent nanoparticles for efficient preparation of a bioprobe .  Colloids and Surfaces B: Biointerfaces224   113192   2023.4

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    Language:Japanese   Publisher:Colloids and Surfaces B: Biointerfaces  

    Single-chain variable fragment antibody (scFv) is a small molecular weight antibody that can be used for both therapeutic and diagnostic purposes. To visualize the interaction with the target biomolecules, scFv must be labeled with fluorescent molecules. In this study, to achieve the efficient labeling of scFv, we developed scFv-fluorescent nanoparticle conjugates to utilize scFv as bioprobes. As fluorescent carriers, cadmium-free ZnS-AgInS2/ZnS core/shell nanoparticles were used, and scFv was immobilized onto the nanoparticles via the interaction of nickel ions on nitrilotriacetic acid and hexahistidine (His-tag) fused with scFv. UV-Vis, fluorescence spectra, NMR, and dynamic laser scattering were used to characterize the scFv immobilized fluorescent nanoparticles (scFv-FNPs). The amounts of scFv on FNPs were controlled by the concentration of scFv. The scFv-FNPs that were prepared were non-toxic and selectively bound to cancer cells. The scFv-FNPs could be used as bioanalytical tools, and the immobilization method described here is a promising method for labeling biomolecules with the His-tag.

    DOI: 10.1016/j.colsurfb.2023.113192

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  • Kucho K.I., Hashimoto M., Normand P., Fournier P., Pujic P. .  Structure of surface polysaccharides affects symbiotic nitrogen fixation in Frankia alni ACN14a .  Journal of Forest Research28 ( 2 ) 152 - 158   2023

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    Language:Japanese   Publisher:Journal of Forest Research  

    Frankia spp. are nitrogen-fixing actinobacteria that establish root-nodule symbiosis with actinorhizal plants comprising more than 200 species in eight dicotyledonous families. From a cell population of Frankia alni strain ACN14a that had been subcultured for over 30 years, we identified two types of variants (types A and S) with a different colony appearance. Type A variants exhibited ambiguous, and type S variants exhibited sharp colony edges. The two types differed in molecular weight and monosaccharide composition of cell surface polysaccharides, which could be responsible for the differences in colony appearance. When inoculated to a host plant Alnus glutinosa, both types induced nodulation but plants infected with type S isolates showed much lower nitrogen fixation activity than those infected with type A isolates. Indeed, type S isolates developed fewer vesicles inside infected plant cells. These results suggest that surface polysaccharides of Frankia play important roles in symbiotic interactions with actinorhizal plants.

    DOI: 10.1080/13416979.2022.2136561

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  • Kananizadeh P., Tada T., Oshiro S., Hishinuma T., Tohya M., Uehara Y., Kumagai Y., Nagaoka I., Nishi K., Hashimoto M., Watanabe S., Kirikae T. .  Modified Drug-Susceptibility Testing and Screening Culture Agar for Colistin-Susceptible Enterobacteriaceae Isolates Harboring a Mobilized Colistin Resistance Gene mcr-9 .  Journal of Clinical Microbiology60 ( 12 )   2022.12

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    Language:Japanese   Publisher:Journal of Clinical Microbiology  

    Three isolates of the Enterobacter cloacae complex harboring mcr-9, a member of the colistin resistance mcr gene family encoded on plasmids, were susceptible to colistin, with MICs of 0.125 to 0.5 μg/mL in standard broth microdilution (BMD) tests using cation-adjusted Mueller-Hinton broth (CA-MHB) in accordance with European Committee on Antimicrobial Susceptibility Testing guidelines. In contrast, their MICs for colistin were significantly higher (4 to 128 μg/mL) when BMD tests were performed using brain-heart infusion (BHI) medium, Luria-Bertani (LB) broth, tryptic soy broth (TSB), or CA-MHB supplemented with casein, tryptonen or peptone. Colistin significantly induced mcr-9 expression in a dose-dependent manner when these mcr-9-positive isolates were cultured in BHI or CA-MHB supplemented with peptone/casein. Pretreatment of mcr-9-positive isolates and Escherichia coli DH5α harboring mcr-9 with colistin significantly increased their survival rates against LL-37, a human antimicrobial peptide. Electrospray ionization time-of-flight mass spectrometry analysis showed that a lipid A moiety of lipopolysaccharide was partially modified by phosphoethanolamine in E. coli DH5α harboring mcr-9 when treated with colistin. Of 93 clinical isolates of Enterobacteriaceae, only the mcr-9-positive isolates showed MICs to colistin that were at least 32 times higher in BHI than in CA-MHB. These mcr-9-positive isolates grew on a modified BHI agar, MCR9-JU, containing 3 μg/mL colistin. These results suggest that the BMD method using BHI is useful when performed together with the BMD method using CA-MHB to detect mcr-9-positive isolates and that MCR9-JU agar is useful in screening for Enterobacteriaceae isolates harboring mcr-9 and other colistin-resistant isolates.

    DOI: 10.1128/jcm.01399-22

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  • Elahi M, Nakayama-Imaohji H, Hashimoto M, Tada A, Yamasaki H, Nagao T, Kuwahara T .  The human gut microbe bacteroides thetaiotaomicron suppresses toxin release from clostridium difficile by inhibiting autolysis .  Antibiotics10 ( 2 ) 187   2021.2The human gut microbe bacteroides thetaiotaomicron suppresses toxin release from clostridium difficile by inhibiting autolysisReviewed

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Antibiotics  

    DOI: 10.3390/antibiotics10020187

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  • Thierry Devanthéry, Keisuke Nakamura, Shuhei Hashiguchi, Masahito Hashimoto .  Structure of a heptose-containing polysaccharide derived from Komagataeibacter europaeus NBRC 3261 .  Carbohydrate Research492 ( 107989 ) 1 - 4   2020.6Structure of a heptose-containing polysaccharide derived from Komagataeibacter europaeus NBRC 3261Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.carres.2020.107989

  • Takeda Y, Azuma M, Hatsugai R, Fujimoto Y, Hashimoto M, Fukase K, Matsumoto M, Seya T .  The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cells .  Innate Immunity24 ( 5 ) 323 - 331   2018.7The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cellsReviewed

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Innate Immunity  

    DOI: 10.1177/1753425918777598

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  • Hashimoto M, Matsumoto T, Tamura-Nakano M, Ozono M, Hashiguchi S, Suda Y. .  Characterization of outer membrane vesicles of Acetobacter pasteurianus NBRC3283 .  J. Biosci. Bioeng.125 ( 4 ) 425 - 431   2018.4Characterization of outer membrane vesicles of Acetobacter pasteurianus NBRC3283 Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbiosc.2017.11.006

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  • 2. Hasibul K, Nakayama-Imaohji H, Hashimoto M, Yamasaki H, Ogawa T, Waki J, Tada A, Yoneda S, Tokuda M, Miyake M, Kuwahara T. .  D-tagatose inhibits the growth and biofilm formation of Streptococcus mutans. .  Mol Med Rep17   843 - 851   2018.1D-tagatose inhibits the growth and biofilm formation of Streptococcus mutans.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mmr.2017.8017

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  • 1. Hashimoto M, Satou R, Ozono M, Inagawa H, Soma G-i .  Characterization of the O-antigen polysaccharide derived from Pantoea agglomerans IG1 lipopolysaccharide. .  Carbohydr. Res.449   32 - 36   2017.6Characterization of the O-antigen polysaccharide derived from Pantoea agglomerans IG1 lipopolysaccharide.Reviewed

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    DOI: 10.1016/j.carres.2017.06.017

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  • 2. Hashimoto M, Waki J, Nakayama-Imaohji H, Ozono M, Hashiguchi S, Kuwahara T. .  TLR2-stimulating contaminants in glycoconjugate fractions prepared from Bacteroides fragilis. .  Innate Immun.23 ( 5 ) 449 - 458   2017.5TLR2-stimulating contaminants in glycoconjugate fractions prepared from Bacteroides fragilis.Reviewed

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    DOI: 10.1177/1753425917714313

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  • Hashimoto M, Mizukami M, Osuki KI, Fujiwara N, Suda Y, Uchiumi T. .  Characterization of O-antigen polysaccharide backbone derived from nitric oxide-inducing Mesorhizobium loti MAFF 303099 lipopolysaccharide. .  Carbohydr. Res.445   44 - 50   2017.4Characterization of O-antigen polysaccharide backbone derived from nitric oxide-inducing Mesorhizobium loti MAFF 303099 lipopolysaccharide.Reviewed

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    DOI: 10.1016/j.carres.2017.04.002

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  • Kino Y, Nakayama-Imaohji H, Fujita M, Tada A, Yoneda S, Murakami K, Hashimoto M, Hayashi T, Okazaki K, Kuwahara T .  Counterselection employing mutated pheS for markerless genetic deletion in Bacteroides species. .  Anaerobe42   81 - 88   2016.12Counterselection employing mutated pheS for markerless genetic deletion in Bacteroides species.Reviewed

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    DOI: 10.1016/j.anaerobe.2016.09.004

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  • Hashimoto M, Ozono M, Furuyashiki M, Baba R, Hashiguchi S, Suda Y, Fukase K, Fujimoto Y. .  Characterization of a novel D-glycero-D-talo-oct-2-ulosonic acid-substituted lipid a moiety in the lipopolysaccharide produced by the acetic acid bacterium Acetobacter pasteurianus NBRC 3283. .  J. Biol. Chem. 291 ( 40 ) 21184 - 21194   2016.9Characterization of a novel D-glycero-D-talo-oct-2-ulosonic acid-substituted lipid a moiety in the lipopolysaccharide produced by the acetic acid bacterium Acetobacter pasteurianus NBRC 3283.Reviewed

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    DOI: 10.1074/jbc.M116.751271

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  • Watanabe S, Matsumura K, Iwai H, Funatogawa K, Haishima Y, Fukui C, Okumura K, Kato-Miyazawa M, Hashimoto M, Teramoto K, Kirikae F, Miyoshi-Akiyama T, Kirikae T. .  A Mutation in the 16S rRNA Decoding Region Attenuates the Virulence of Mycobacterium tuberculosis. .  Infect. Immun.84 ( 8 ) 2264 - 2273   2016.7A Mutation in the 16S rRNA Decoding Region Attenuates the Virulence of Mycobacterium tuberculosis.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.00417-16

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  • Hashimoto M, Obara K, Ozono M, Furuyashiki M, Ikeda T, Suda Y, Fukase K, Fujimoto Y, Shigehisa H .  Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu). .  J. Biosci. Bioeng.116 ( 6 ) 688 - 696   2013.12Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu).Reviewed

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    DOI: 10.1016/j.jbiosc.2013.05.029

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  • Fujimoto Y, Mitsunobe K, Fujiwara S, Mori M, Hashimoto M, Suda Y, Kusumoto S, Fukase K. .  Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus. .  Org. Biomol. Chem. 11 ( 30 ) 5034 - 5041   2013.8Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c3ob40899j

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  • Kukita K, Kawada-Matsuo M, Oho T, Nagatomo M, Oogai Y, Hashimoto M, Suda Y, Tanaka T, Komatsuzawa H. .  Staphylococcus aureus SasA is responsible for binding to salivary agglutinin, gp340, derived from human saliva. .  Infect. Immun. 81 ( 6 ) 1870 - 1879   2013.6Staphylococcus aureus SasA is responsible for binding to salivary agglutinin, gp340, derived from human saliva.Reviewed

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  • Hashimoto M, Eguchi H, Tawaratsumida K, Kirikae T, Suda Y .  Identification of a Toll-like receptor 2-stimulating lipoprotein in Bacteroides fragilis JCM 11019 (NCTC 9343). .  Innate Immun.19 ( 2 ) 132 - 139   2013.4Identification of a Toll-like receptor 2-stimulating lipoprotein in Bacteroides fragilis JCM 11019 (NCTC 9343).Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1753425912454179

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  • Hashimoto M, Tanishita Y, Suda Y, Murakami Ei, Nagata M, Kucho Ki, Abe M, Uchiumi T .  Characterization of Nitric Oxide-Inducing Lipid A derived from Mesorhizobium loti Lipopolysaccharide .  Microbes Environ.27 ( 4 ) 490 - 496   2012.12Characterization of Nitric Oxide-Inducing Lipid A derived from Mesorhizobium loti LipopolysaccharideReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1264/jsme2.ME12103

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  • Oogai Y, Matsuo M, Hashimoto M, Kato F, Sugai M, Komatsuzawa H .  Expressions of virulence factors in Staphylococcus aureus grown in serum. .  Appl. Environ. Microbiol.77 ( 22 ) 8097 - 8105   2011.11Expressions of virulence factors in Staphylococcus aureus grown in serum.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AEM.05316-11

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  • Murakami E, Nagata M, Shimoda Y, Kucho K, Higashi S, Abe M, Hashimoto M, Uchiumi T. .  Nitric Oxide Production Induced in Roots of Lotus japonicus by Lipopolysaccharide from Mesorhizobium loti. .  Plant Cell Physiol52 ( 4 ) 610 - 617   2011.4Nitric Oxide Production Induced in Roots of Lotus japonicus by Lipopolysaccharide from Mesorhizobium loti.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/pcp/pcr020

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  • Kariya, K., Yoshihara, Y., Nakao, Y., Sakurai, N., Ueno, M., Hashimoto, M., Suda .  Carboxymethyl chitin promotes chondrogenesis by inducing the production of growth factors from immune cells .  J. Biomed. Mater. Res.94 ( 4 ) 1034 - 1041   2010.9Carboxymethyl chitin promotes chondrogenesis by inducing the production of growth factors from immune cellsReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbm.a.32771

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  • Azuma M, Sawahata R, Akao Y, Ebihara T, Yamazaki S, Matsumoto M, Hashimoto M, Fukase K, Fujimoto Y, Seya T. .  The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation. .  PLoS One. 5 ( 9 ) e12550   2010.9The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0012550

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  • Fujimoto Y, Hashimoto M, Furuyashiki M, Katsumoto M, Seya T, Suda Y, Fukase K. .  Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: prediction with mrna expression, chemical synthesis, and immunostimulatory activities. .  Chembiochem.10 ( 14 ) 2311 - 2315   2009.9Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: prediction with mrna expression, chemical synthesis, and immunostimulatory activities. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbic.200900242

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  • Tawaratsumida K, Furuyashiki M, Katsumoto M, Fujimoto Y, Fukase K, Suda Y, Hashimoto M. .  Characterization of N-terminal structure of TLR2-activating lipoprotein in Staphylococcus aureus. .  J. Biol. Chem.284 ( 14 ) 9147 - 9152   2009.4Characterization of N-terminal structure of TLR2-activating lipoprotein in Staphylococcus aureus.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M900429200

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  • Carmelo Segovia del Castillo, Takeshi Yoshikawa, Masahito Hashimoto and Taizo Sakata, .  Correlation between Chemical Structures and Inhibitory Activities of Anti-bacterial Substances from Marine Pseudoalteromonas sp. A1-J11 .  Fish Pathol. 43 ( 2 ) 65 - 71   2008.7Correlation between Chemical Structures and Inhibitory Activities of Anti-bacterial Substances from Marine Pseudoalteromonas sp. A1-J11Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3147/jsfp. 43.65

  • Hashimoto, M., Takashige, K., Furuyashiki, M., Yoshidome, K., Sano, R., Kawamura, Y., Ijichi, S., Morioka, H., Koide, H., Oku, M., Moriya, Y., Kusumoto, S., Suda, Y. .  Enhancement of antitumor activity of OK-432 (Picibanil) by Triton X-114 phase partitioning. .  Int. Immunopharmacol. 8 ( 1 ) 12 - 19   2008.1Enhancement of antitumor activity of OK-432 (Picibanil) by Triton X-114 phase partitioning.Reviewed

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    DOI: 10.1016/j.intimp.2007.09.021

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  • Kariya H, Kiyohara A, Masuda S, Yoshihara Y, Ueno M, Hashimoto M, Suda Y. .  Biological roles of carboxymethyl-chitin associated for the growth factor production. .  J. Biomed. Mater. Res. Part A83 ( 1 ) 58 - 63   2007.10Biological roles of carboxymethyl-chitin associated for the growth factor production.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jbm.a.31202

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  • Hashimoto M, Furuyashiki M, Kaseya R, Fukada Y, Akimaru M, Aoyama K, Okuno T, Tamura T, Kirikae T, Kirikae F, Eiraku N, Morioka H, Fujimoto Y, Fukase K, Takashige K, Moriya Y, Kusumoto S, Suda Y .  Evidence of immunostimulating lipoprotein co-existing in natural lipoteichoic acid fraction. .  Infect. Immun. 75 ( 4 ) 1926 - 1932   2007.4Evidence of immunostimulating lipoprotein co-existing in natural lipoteichoic acid fraction.Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.02083-05

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  • Hasegawa M, Yang K, Hashimoto M, Park JH, Fujimoto Y, Nunez G, Fukase K, Inohara N .  Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments. .  J. Biol. Chem.281 ( 39 ) 29054 - 29063   2006.9Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M602638200

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  • Hashimoto M, Tawaratsumida K, Kariya H, Kiyohara A, Suda Y, Krikae F, Kirikae T, Goetz F .  Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus. .  J. Immunol.177 ( 5 ) 3162 - 3169   2006.9Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus.Reviewed

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    DOI: 10.4049/jimmunol.178.5.2610-a

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  • M.Hashimoto, K.Tawaratsumida, H.Kariya, K.Aoyama, T.Tamura, Y.Suda .  Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components. .  Int. Immunol18 ( 2 ) 355 - 362   2006.2Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components.Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/dxh374

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  • Y.Asai, Y.Ohyama, Y.Taiji, Y.Makimura, R.Tamai, M.Hashimoto, T.Ogawa .  Treponema medium glycoconjugate inhibits activation of human gingival fibroblasts stimulated with phenol-water extracts of periodontopathic bacteria. .  J. Dent. Res84 ( 5 ) 456 - 461   2005.5Treponema medium glycoconjugate inhibits activation of human gingival fibroblasts stimulated with phenol-water extracts of periodontopathic bacteria.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/154405910508400511

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  • Y.Asai, M.Hashimoto, H.M.Fletcher, K.Miyake,S.Akira, T.Ogawa .  Lipopolysaccharide Preparation Extracted from Porphyromonas gingivalis Lipoprotein-Deficient Mutant Shows a Marked Decrease in Toll-Like Receptor 2-Mediated Signaling. .  Infect. Immun.73 ( 4 ) 2157 - 2163   2005.4Lipopolysaccharide Preparation Extracted from Porphyromonas gingivalis Lipoprotein-Deficient Mutant Shows a Marked Decrease in Toll-Like Receptor 2-Mediated Signaling.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.73.4.2157-2163.2005

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  • M. Hashimoto, Y. Asai , T. Ogawa .  Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis .  Int. Immunol16 ( 10 ) 1431 - 1437   2004.10Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalisReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/dxh146

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Books

  • エンドトキシン・自然免疫研究22

    橋本雅仁( Role: Sole author)

    医学図書出版  2019.11 

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    Total pages:82   Responsible for pages:54-57   Language:Japanese Book type:Scholarly book

  • エンドトキシン・自然免疫研究21

    脇 純平,今大路浩之,大薗 まみ,橋口 周平,桑原 知巳,橋本 雅仁( Role: Joint author)

    医学図書出版  2018.10 

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    Total pages:69   Responsible for pages:18-22   Language:Japanese Book type:Scholarly book

  • エンドトキシン・自然免疫研究20

    3. 橋本雅仁、馬場梨沙子、大薗まみ、橋口周平、隅田泰生、深瀬浩一、藤本ゆかり( Role: Joint author)

    医学図書出版  2017.10 

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    Total pages:67   Responsible for pages:57-59   Language:Japanese Book type:Scholarly book

  • エンドトキシン・自然免疫研究 18

    橋本雅仁( Role: Sole author)

    医学図書出版  2015.9 

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    Total pages:100   Responsible for pages:65-68   Language:Japanese Book type:Scholarly book

  • エンドトキシン・自然免疫研究 16

    橋本雅仁、隅田泰生、俵積田一樹( Role: Joint author)

    医学図書出版  2013.10 

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    Total pages:39   Responsible for pages:35-39   Language:Japanese Book type:Scholarly book

  • エンドトキシン・自然免疫研究 14

    小野敬子、俵積田一樹、隅田泰生、橋本雅仁( Role: Joint author)

    医学図書出版  2011.11 

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    Total pages:88   Responsible for pages:86-88   Language:Japanese Book type:Scholarly book

  • エンドトキシン研究 12

    俵積田一樹、橋本雅仁、隅田泰生( Role: Joint author)

    医学図書出版  2009.11 

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    Total pages:121   Responsible for pages:75-77   Language:Japanese Book type:Scholarly book

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MISC

  • Structure and synthesis of lipid A. Reviewed

    Kusumoto S, Hashimoto M, Kawahara K.

    Adv. Exp. Med. Biol.   667   5 - 23   2010.8

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1007/978-1-4419-1603-7_2

    PubMed

  • グラム陰性菌のペプチドグリカンを認識する Nod1 と自然免疫 Reviewed

    橋本雅仁、猪原直弘

    臨床免疫   41 ( 3 )   309 - 313   2004.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Presentations

  • 牧百合恵、大薗まみ、橋口周平、橋本雅仁   酢酸菌由来外膜小胞のアジュバント活性  

    第94回日本生化学会大会  2021.11  日本生化学会

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    Event date: 2021.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:オンライン   Country:Japan  

  • 橋本雅仁   酢酸菌の自然免疫活性化物質   Invited

    自然免疫制御技術研究組合第9回シンポジウム  2021.3  自然免疫制御技術研究組合

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京都港区   Country:Japan  

  • 橋本雅仁、馬場梨沙子、牧百合恵、大薗まみ、橋口周平   酢酸菌由来外膜小胞の免疫調整能  

    第92回日本細菌学会総会  2019.4  日本細菌学会

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    Event date: 2019.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:北海道札幌市   Country:Japan  

  • 橋本雅仁   酢酸菌による外膜小胞の産生とその性質  

    第24回日本エンドトキシン・自然免疫研究会  日本エンドトキシン・自然免疫研究会

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    Event date: 2018.11 - 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:関東学院大・関内メディアセンター  

  • Masahito Hashimoto   Immunostimulatory components in kurozu   International conference

    4th KU-NDSU Joint Symposium on Biotechnology, Nanomaterials and Polymers (KNJS2018)  KU-NDSU Joint Symposium on Biotechnology, Nanomaterials and Polymers

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    Event date: 2018.10 - 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Kagoshima University  

  • 橋本雅仁、松元太一、中村佳祐、大薗まみ、橋口周平   酢酸菌由来外膜小胞の収量改善の検討  

    第70回日本生物工学会大会 (2018)  日本生物工学会

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:関西大学千里山キャンパス  

  • 橋本雅仁、松元太一、中村佳祐、馬場梨沙子、大薗まみ、橋口周平   Acetobacter pasteurianus 由来外膜小胞の分離と免疫刺激能  

    2017年度生命科学系学会合同年次大会 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸市  

  • 橋本雅仁   酢酸菌リポ多糖の構造と生物活性   Invited

    酢酸菌研究会第9回研究集会  酢酸菌研究会

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:愛知県半田市  

  • 橋本雅仁、松元太一、馬場梨沙子、大薗まみ、橋口周平   酢酸菌由来外膜小胞の産生と性質  

    第69回日本生物工学会  日本生物工学会

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:早稲田大学 西早稲田キャンパス  

  • 橋本雅仁   黒酢に含まれる細菌成分とその生物活性   Invited

    動物植物生態三学会合同鹿児島例会  動物植物生態三学会

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    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:鹿児島大学理学部  

  • 橋本雅仁   酢酸菌由来リポ多糖と黒酢   Invited

    第52回自然免疫賦活技術研究会  自然免疫賦活技術研究会

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:高松センタービル TCB 会議室  

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Intellectual Property

  • 植物免疫活性化剤

    橋本雅仁、内海俊樹

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    Applicant:国立大学法人鹿児島大学

    Application no:2018-106085  Date applied:2018.6

Awards

  • 奨励賞

    2014.12   日本エンドトキシン・自然免疫研究会   細菌由来の複合糖質画分に莢雑する自然免疫活性化リポタンパク質の研究

    橋本 雅仁

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    Country:Japan