Updated on 2023/10/26

写真a

 
MIYATA Atsuro
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences ?Joint research course Professor
Research Field in Cooperation, Integrated Arts and Sciences Area Southern Kyushu and Nansei Islands Innovation Center University Research Administration Center Professor
Title
Professor
Profile
○PACAP遺伝子の構造と発現調節に関する研究 ○PACAPの神経栄養作用の分子機序に関する研究 ○PACAP特異的受容体PAC1の機能と遺伝子発現調節に関する研究、○オーファンGPCRのリガンド探索と機能解析に関する研究

Degree

  • 医学博士 ( 1985.3   宮崎医科大学 )

Research Interests

  • 下垂体アデニル酸シクラーゼ活性化ペプチド

  • GPCR

  • 循環調節因子

  • 神経ペプチド

  • 神経栄養因子

  • 遺伝子発現調節

  • PACAP

Research Areas

  • Life Science / Pharmacology  / molecular pharmacology

  • Life Science / Medical biochemistry  / peptide chemistry

  • Life Science / Metabolism and endocrinology  / hypothalamus, food intake

Education

  • Miyazaki Medical College   Graduate School   Doctoral Course

    1981.4 - 1985.3

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    Country: Japan

  • Miyazaki Medical College

    1975.4 - 1981.3

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    Country: Japan

Research History

  •   医学部第2生化学講座   日本学術振興会研究員(リサーチ・アソシエイト)

    1986.4 - 1987.3

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    Country:Japan

  • Miyazaki Medical College   Special researcher of the Japan Society for the Promotion of Science

    1987.4 - 1987.7

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    Country:Japan

  • Tulane University   Faculty of Medicine, Department of Internal Medicine   Assistant Professor

    1987.7 - 1989.10

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    Country:United States

  • 国立循環器病センター研究所   薬理部   研究員

    1989.11 - 1994.3

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    Country:Japan

  • 国立循環器病センター研究所   生化学部   室長

    1994.4 - 2000.10

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    Country:Japan

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine   Professor

    2000.11 - 2003.3

  • Kagoshima University   Professor

    2003.4 - 2022.3

  • Kagoshima University   etcetera University Research Administration Center   Director in General

    2018.4 - 2021.3

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    Country:Japan

  • Kagoshima University   Advanced biomedical science and swine research center   Director in General   M.D. & Ph.D.

    2021.4 - 2022.3

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    Country:Japan

  • Kagoshima University   Graduate School of Medical and Dental Sciences, DDS Drug discovery laboratory   Professor   M.D. & Ph.D.

    2022.4

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    Country:Japan

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Professional Memberships

  • 日本薬理学会

    2000.11

  • 日本生化学会

    1982.4

  • 日本内分泌学会

    1983.4

Committee Memberships

  • 日本薬理学会   第95回日本薬理学会年会 年会長  

    2021.4 - 2022.3   

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    Committee type:Academic society

  • 日本薬理学会    年会学術企画委員会  

    2014.4 - 2016.3   

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    Committee type:Academic society

    委員長

Studying abroad experiences

  • 1987.7 - 1989.11   チューレン大学医学部、米国   Research Instructor

 

Papers

  • Kambe Y., Nguyen T.T., Yasaka T., Nguyen T.T., Sameshima Y., Hashiguchi K., Shintani N., Hashimoto H., Kurihara T., Miyata A. .  The Pivotal Role of Neuropeptide Crosstalk from Ventromedial-PACAP to Dorsomedial-Galanin in the Appetite Regulation in the Mouse Hypothalamus .  Molecular Neurobiology60 ( 1 ) 171 - 182   2023.1

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    Language:Japanese   Publisher:Molecular Neurobiology  

    We have previously shown that pituitary adenylate cyclase-activating polypeptide (PACAP) in the ventromedial hypothalamus (VMH) enhances feeding during the dark cycle and after fasting, and inhibits feeding during the light cycle. On the other hand, galanin is highly expressed in the hypothalamus and has been reported to be involved in feeding regulation. In this study, we investigated the involvement of the VMH-PACAP to the dorsomedial hypothalamus (DMH)-galanin signaling in the regulation of feeding. Galanin expression in the hypothalamus was significantly increased with fasting, but this increment was canceled in PACAP-knockout (KO) mice. Furthermore, overexpression of PACAP in the VMH increased the expression of galanin, while knockdown (KD) of PACAP in the VMH decreased the expression of galanin, indicating that the expression of galanin in the hypothalamus might be regulated by PACAP in the VMH. Therefore, we expressed the synaptophysin-EGFP fusion protein (SypEGFP) in PACAP neurons in the VMH and visualized the neural projection to the hypothalamic region where galanin was highly expressed. A strong synaptophysin-EGFP signal was observed in the DMH, indicating that PACAP-expressing cells of the VMH projected to the DMH. Furthermore, galanin immunostaining in the DMH showed that galanin expression was weak in PACAP-KO mice. When galanin in the DMH was knocked down, food intake during the dark cycle and after fasting was decreased, and food intake during the light cycle was increased, as in PACAP-KO mice. These results indicated that galanin in the DMH may regulate the feeding downstream of PACAP in the VMH.

    DOI: 10.1007/s12035-022-03084-y

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  • Kawamura N., Katsuura G., Yamada-Goto N., Nakama R., Kambe Y., Miyata A., Furuyashiki T., Narumiya S., Ogawa Y., Inui A. .  Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice .  Scientific Reports12 ( 1 ) 12604   2022.12

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    Language:Japanese   Publisher:Scientific Reports  

    Fractalkine is one of the CX3C chemokine family, and it is widely expressed in the brain including the hypothalamus. In the brain, fractalkine is expressed in neurons and binds to a CX3C chemokine receptor 1 (CX3CR1) in microglia. The hypothalamus regulates energy homeostasis of which dysregulation is associated with obesity. Therefore, we examined whether fractalkine-CX3CR1 signalling involved in regulating food intake and hypothalamic inflammation associated with obesity pathogenesis. In the present study, fractalkine significantly reduced food intake induced by several experimental stimuli and significantly increased brain-derived neurotrophic factor (BDNF) mRNA expression in the hypothalamus. Moreover, tyrosine receptor kinase B (TrkB) antagonist impaired fractalkine-induced anorexigenic actions. In addition, compared with wild-type mice, CX3CR1-deficient mice showed a significant increase in food intake and a significant decrease in BDNF mRNA expression in the hypothalamus. Mice fed a high-fat diet (HFD) for 16 weeks showed hypothalamic inflammation and reduced fractalkine mRNA expression in the hypothalamus. Intracerebroventricular administration of fractalkine significantly suppressed HFD-induced hypothalamic inflammation in mice. HFD intake for 4 weeks caused hypothalamic inflammation in CX3CR1-deficient mice, but not in wild-type mice. These findings suggest that fractalkine-CX3CR1 signalling induces anorexigenic actions via activation of the BDNF-TrkB pathway and suppresses HFD-induced hypothalamic inflammation in mice.

    DOI: 10.1038/s41598-022-16944-3

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  • Kambe Y., Youkai M., Hashiguchi K., Sameshima Y., Takasaki I., Miyata A., Kurihara T. .  Spinal Astrocyte-Neuron Lactate Shuttle Contributes to the Pituitary Adenylate Cyclase-Activating Polypeptide/PAC1 Receptor-Induced Nociceptive Behaviors in Mice .  Biomolecules12 ( 12 )   2022.12

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    Language:Japanese   Publisher:Biomolecules  

    We have previously shown that spinal pituitary adenylate cyclase-activating polypeptide (PACAP)/PACAP type 1 (PAC1) receptor signaling triggered long-lasting nociceptive behaviors through astroglial activation in mice. Since astrocyte-neuron lactate shuttle (ANLS) could be essential for long-term synaptic facilitation, we aimed to elucidate a possible involvement of spinal ANLS in the development of the PACAP/PAC1 receptor-induced nociceptive behaviors. A single intrathecal administration of PACAP induced short-term spontaneous aversive behaviors, followed by long-lasting mechanical allodynia in mice. These nociceptive behaviors were inhibited by 1,4-dideoxy-1,4-imino-d-arabinitol (DAB), an inhibitor of glycogenolysis, and this inhibition was reversed by simultaneous L-lactate application. In the cultured spinal astrocytes, the PACAP-evoked glycogenolysis and L-lactate secretion were inhibited by DAB. In addition, a protein kinase C (PKC) inhibitor attenuated the PACAP-induced nociceptive behaviors as well as the PACAP-evoked glycogenolysis and L-lactate secretion. Finally, an inhibitor for the monocarboxylate transporters blocked the L-lactate secretion from the spinal astrocytes and inhibited the PACAP- and spinal nerve ligation-induced nociceptive behaviors. These results suggested that spinal PAC1 receptor-PKC-ANLS signaling contributed to the PACAP-induced nociceptive behaviors. This signaling system could be involved in the peripheral nerve injury-induced pain-like behaviors.

    DOI: 10.3390/biom12121859

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  • Shintani Y., Yamano Y., kuta M., Takeshita R., Takuma K., Okada T., Toyooka N., Takasaki I., Miyata A., Kurihara T., Hashimoto H., Hayata-Takano A. .  Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice .  Biochemical and Biophysical Research Communications631   146 - 151   2022.11

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    Language:Japanese   Publisher:Biochemical and Biophysical Research Communications  

    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved pleiotropic neuropeptide, implicated in emotional stress responses and anxiety-related disorders. Here, we examined whether our recently developed small-molecule non-peptide PACAP receptor antagonists could ameliorate anxiety-like behaviors induced by acute restraint stress in mice. The antagonists PA-9 and its derivative PA-915 improved anxiety-like behaviors in mice subjected to restraint stress. An anxiolytic effect was observed with single acute dose, suggesting their fast-acting properties. PA-915 demonstrated a statistically significant anxiolytic effect whereas fluoxetine did not. These results indicate the potential of PAC1 antagonists as a novel treatment for anxiety.

    DOI: 10.1016/j.bbrc.2022.09.079

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  • Takasaki I. .  Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist .  European Journal of Medicinal Chemistry231   114160   2022.3

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    Language:Japanese   Publisher:European Journal of Medicinal Chemistry  

    Since PA-8 (5-(4-(Allyloxy)-3-methoxyphenyl)-2-amino-5,8-dihydro-3H,6H-pyrido[2,3-d]pyrimidine-4,7-dione) was recently identified as a novel small-molecule antagonist of the pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor, a series of pyrido[2,3-d]pyrimidine derivatives have been designed, synthesized and subsequently evaluated for antagonistic activity on the PAC1 receptor. In this study, we synthesized 21 derivatives based on the PA-8 structure. Among them, the compound 2o (2-Amino-5-(3-trifluoromethoxy-phenyl)-5,8-dihydro-3H,6H-pyrido[2,3-d]pyrimidine-4,7-dione) showed more potent antagonistic activities than PA-8. Intrathecal (i.t.) injection of 2o blocked the induction of PACAP-induced aversive behaviors and mechanical allodynia in mice, and the effects were more potent than those of PA-8. A single i.t. injection of 2o also inhibited spinal nerve ligation (SNL)-induced mechanical allodynia. Repeated intraperitoneal administration of 2o gradually reduced the SNL-induced mechanical allodynia, and this effect appeared earlier than for PA-8. In addition, 2o exhibited a favorable ADME and pharmacokinetics profiles. These results suggest that 2o may become an analgesic for the treatment of neuropathic pain.

    DOI: 10.1016/j.ejmech.2022.114160

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  • Kambe Yuki, Thi Thu Nguyen, Hashiguchi Kohei, Sameshima Yoshimune, Yamashita Akira, Kurihara Takashi, Miyata Atsuro .  The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice(和訳中) .  Journal of Pharmacological Sciences148 ( 1 ) 108 - 115   2022.1The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice(和訳中)

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    マウスの背側海馬におけるprotein targeting to glycogen(PTG)の発現をノックダウンし、PTGの機能を行動学的に解析した。PTGはアストロサイトで高発現していた。PTGに対するshRNAはアストロサイトにおけるPTG発現を抑制した。背側海馬のPTGをノックダウンしたマウスではY迷路試験での交替行動、および受動回避試験での記憶の獲得から1時間後にて想起が抑制された。マウス背側海馬のアストロサイト特異的PTGのノックダウンにより、Y迷路試験での作業記憶に障害が生じた。PTGノックダウンマウスの背側海馬で、GluR1、GluR2およびNR2aサブユニットの発現が下方制御された。

  • Kambe Y. .  The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice .  Journal of Pharmacological Sciences148 ( 1 ) 108 - 115   2022.1

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    Language:Japanese   Publisher:Journal of Pharmacological Sciences  

    DOI: 10.1016/j.jphs.2021.10.008

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  • Kambe Y. .  The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice .  Journal of Pharmacological Sciences148 ( 1 ) 108 - 115   2022.1

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    Language:Japanese   Publisher:Journal of Pharmacological Sciences  

    DOI: 10.1016/j.jphs.2021.10.008

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  • Kambe Y. .  The dorsal hippocampal protein targeting to glycogen maintains ionotropic glutamate receptor subunits expression and contributes to working and short-term memories in mice .  Journal of Pharmacological Sciences148 ( 1 ) 108 - 115   2022.1

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    Language:Japanese   Publisher:Journal of Pharmacological Sciences  

    DOI: 10.1016/j.jphs.2021.10.008

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  • Miyata Atsuro .  From Discovery to Clinical application of PACAP .  Proceedings for Annual Meeting of The Japanese Pharmacological Society95 ( 0 ) 1-CL   2022From Discovery to Clinical application of PACAP

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    <p>Pituitary adenylate cyclase-activating polypeptides (PACAPs) were discovered in the 1980s in the process of searching for unknown hypothalamic factors after the successive discovery of hypophysiotorpic hormones such as TRH, GHRH, and CRH. PACAP38, consisting of 38 amino acids, and PACAP27, consisting of 27 residues at its N-terminus, were isolated and identified from sheep hypothalamic extracts in 1989 using the stimulatory activity of cyclic AMP production in rat pituitary cells. Their structures show 68% homology to vasoactive intestinal peptide (VIP) and belong to the secretin-glucagon family. PACAP38 is widely distributed in the brain, with the highest concentration in the hypothalamus, where it promotes the secretion of almost all pituitary hormones. PACAP38 is widely distributed in the brain and is found in highest concentration in the hypothalamus, but it promotes the secretion of almost all pituitary hormones, and its full physiological function in the hypothalamus has yet to be elucidated. However, focusing on its function as a neurotrophic factor, we aim to apply it clinically as an agonist in the treatment of ischemic brain diseases such as stroke and neurodegenerative diseases. In the meantime, research is being conducted on the clinical application of antagonists for the treatment of intractable pain based on their function in pain transmission as neurotransmitters.</p>

    DOI: 10.1254/jpssuppl.95.0_1-cl

  • Sadamura Y. .  FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice .  Frontiers in Pharmacology12   699026   2021.8

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    Language:Japanese   Publisher:Frontiers in Pharmacology  

    DOI: 10.3389/fphar.2021.699026

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  • Sadamura Y. .  FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice .  Frontiers in Pharmacology12   699026   2021.8

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    Language:Japanese   Publisher:Frontiers in Pharmacology  

    DOI: 10.3389/fphar.2021.699026

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  • Sadamura Y. .  FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice .  Frontiers in Pharmacology12   699026   2021.8

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    Language:Japanese   Publisher:Frontiers in Pharmacology  

    DOI: 10.3389/fphar.2021.699026

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  • Kambe Y. .  The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory .  Pharmacological Reports73 ( 4 ) 1109 - 1121   2021

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    Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) plays an essential role in the modulation of astrocyte functions. Although lactate secretion from astrocytes contributes to many forms of neuronal plasticity in the central nervous system, including fear learning and memory, the role of PACAP in lactate secretion from astrocytes is unclear. Methods: The amygdala and hippocampus of PACAP (+ / +) and PACAP (−/−) mice were acquired 1 h after memory acquisition and recall in the passive avoidance test. The concentration of glycogen and lactate in these regions was measured. The concentration of lactate in the hippocampus's extracellular fluid was also measured by microdialysis during memory acquisition or intracerebroventricular administration of PACAP. Results: We observed that memory acquisition caused a significant decrease in glycogen concentration and increased lactate concentration in the PACAP (+ / +) mice's hippocampus. However, memory acquisition did not increase in the lactate concentration in PACAP (−/−) mice's hippocampus. Further, memory retrieval evoked lactate production in the amygdala and the hippocampus of PACAP (+ / +) mice. Still, there was no significant increase in lactate concentration in the same regions of PACAP (−/−) mice. In vivo microdialysis in rats revealed that the hippocampus's extracellular lactate concentration increased after a single PACAP intracerebroventricular injection. Additionally, the hippocampus's extracellular lactate concentration increased with the memory acquisition in PACAP (+ / +) mice, but not in PACAP (−/−) mice. Conclusions: PACAP may enhance lactate production and secretion in astrocytes during the acquisition and recall of fear memories. Graphic abstract: [Figure not available: see fulltext.]

    DOI: 10.1007/s43440-021-00222-6

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  • Karki, P, Kurihara, T, Nakamachi, T, Watanabe, J, Asada, T, Oyoshi, T, Shioda, S, Yoshimura, M, Arita, K, Miyata, A .  Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40 .  Mol Pain11   6   2015.2Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40Reviewed

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  • Kambe, Y. and Miyata, A. .  Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice .  Neurosci Lett588   166 - 171   2015.1Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in miceReviewed

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  • Sugawara H, Tominaga A, Inoue K, Takeda Y, Yamada K, Miyata A .  Functional Characterization of Neural-Restrictive Silencer Element in Mouse Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Gene Expression .  J. Mol. Neurosc.54 ( 3 ) 526 - 534   2014.11Functional Characterization of Neural-Restrictive Silencer Element in Mouse Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Gene ExpressionReviewed

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  • Kurihara T, Sakurai E, Toyomoto M, Kii I, Kawamoto D, Asada T, Tanabe T, Yoshimura M, Hagiwara M, Miyata A. .  Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. .  Molecular Pain   2014.3Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.Reviewed

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  • Bohara M, Kambe Y, Nagayama T, Tokimura H, Arita K, Miyata A .  C-type natriuretic peptide modulates permeability of the blood-brain barrier. .  J Cereb Blood Flow Metab.34 ( 4 ) 589 - 596   2014.1C-type natriuretic peptide modulates permeability of the blood-brain barrier.Reviewed

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  • Hanada T, Kurihara T, Tokudome M, Tokimura H, Arita K, Miyata A. .  Development and pharmacological verification of a new mouse model of central post-stroke pain. .  Neurosci Res.78   72 - 80   2014.1Development and pharmacological verification of a new mouse model of central post-stroke pain. Reviewed

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  • Miura A, Kambe Y, Inoue K, Tatsukawa H, Kurihara T, Griffin M, Kojima S, Miyata A .  Pituitary Adenylate Cyclase-activating Polypeptide Type 1 Receptor (PAC1) Gene Is Suppressed by Transglutaminase 2 Activation .  The Journal of biological chemistry288   32720 - 32730   2013.11Pituitary Adenylate Cyclase-activating Polypeptide Type 1 Receptor (PAC1) Gene Is Suppressed by Transglutaminase 2 ActivationReviewed

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  • Saito H, Nakamachi T, Inoue K, Ikeda R, Kitamura K, Minamino N, Shioda S, Miyata A .  Autocrine Effects of Neuromedin B Stimulate the Proliferation of Rat Primary Osteoblasts. .  J Endocrinol217 ( 2 ) 141 - 150   2013.4Autocrine Effects of Neuromedin B Stimulate the Proliferation of Rat Primary Osteoblasts.Reviewed

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  • Kambe Y, Miyata A. .  Role of Mitochondrial Activation in PACAP Dependent Neurite Outgrowth. .  J Mol Neurosci48 ( 3 ) 550 - 557   2012.11Role of Mitochondrial Activation in PACAP Dependent Neurite Outgrowth.Reviewed

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  • Miura A, Odahara N, Tominaga A, Inoue K, Kambe Y, Kurihara T, Miyata A .  Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells .  FEBS Lett586 ( 12 ) 1731 - 1735   2012.7Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cellsReviewed

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  • Saito H, Ikeda R, Inoue K, Nagata S, Kitamura K, Minamino N, Kangawa K, Miyata A. .  Neuromedin B stimulates proliferation of mouse chondrogenic cell line ATDC5 .  Peptides36 ( 2 ) 299 - 302   2012.4Neuromedin B stimulates proliferation of mouse chondrogenic cell line ATDC5Reviewed

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  • Takenouchi R, Inoue K, Kambe Y, Miyata A. .  N-arachidonoyl glycine induces macrophage apoptosis via GPR18. .  Biochem Biophys Res Commun.418 ( 2 ) 366 - 371   2012.1N-arachidonoyl glycine induces macrophage apoptosis via GPR18.Reviewed

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  • Ushiyama M, Ikeda R, Yoshida M, Mori K, Kangawa K, Sugawara H, Inoue K, Yamada K, Miyata A .  Alternative splicing of the pituitary adenylate cyclase-activating polypetide (PACAP) receptor contributes to function of PACAP-27 .  Journal of Molecular Neuroscience42 ( 3 ) 341 - 348   2010.5Alternative splicing of the pituitary adenylate cyclase-activating polypetide (PACAP) receptor contributes to function of PACAP-27Reviewed

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  • Tominaga A, Sugawara H, Futagawa T, Inoue K, Sasaki K, Minamino N, Hatakeyama M, Handa H, Miyata A .  Characterization of the testis-specific promoter region in the human pituitary adenylate cyclase-activating polypeptide (PACAP) gene. 査読有): 595-606, 2010. .  Genes to Cells15 ( 6 ) 595 - 606   2010.5Characterization of the testis-specific promoter region in the human pituitary adenylate cyclase-activating polypeptide (PACAP) gene. 査読有): 595-606, 2010.Reviewed

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  • Tominaga A, Sugawara H, Inoue K, Miyata A. .  Implication of pituitary adenylate cyclase-activating polypeptide (PACAP) for neuroprotection of nicotinic acetylcholine receptor signaling in PC12 cells .  Journal of molecular neuroscience36   73 - 78   2008.7Implication of pituitary adenylate cyclase-activating polypeptide (PACAP) for neuroprotection of nicotinic acetylcholine receptor signaling in PC12 cellsReviewed

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  • Ushiyama.M, Ikeda.R, Yoshida.M, Mori.K, Kangawa.K, Inoue.K, Yamada.k, Miyata.A .  Diferential Intracellucular Signaling through PAC1 Isoforms as a Result of Alternative Splicing in the First Extracellular Domain and the Third Intracellular Loop .  Molecular Pharmacology 72 ( 1 ) 103 - 111   2007Diferential Intracellucular Signaling through PAC1 Isoforms as a Result of Alternative Splicing in the First Extracellular Domain and the Third Intracellular LoopReviewed

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  • Ushiyama M, Sugawara H, Inoue K, Kangawa K, Miyata A .  Characterization of the PAC1 Variants Expressed in the Mouse Heart .  ANN. N.Y. ACAD. SCI.・Blackwell Publishing1070   586 - 590   2006.1Characterization of the PAC1 Variants Expressed in the Mouse HeartReviewed

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  • Nguyen T.T. .  Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice .  Molecular Neurobiology57 ( 4 ) 2101 - 2114   2020.4

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    Publisher:Molecular Neurobiology  

    DOI: 10.1007/s12035-019-01864-7

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  • Takasaki I. .  Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain .  European Journal of Medicinal Chemistry186   111902   2020.1

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    Publisher:European Journal of Medicinal Chemistry  

    DOI: 10.1016/j.ejmech.2019.111902

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  • Takasaki Ichiro, Nakamura Koji, Shimodaira Ayaka, Watanabe Ai, Nguyen Huy Du, Okada Takuya, Toyooka Naoki, Miyata Atsuro, Kurihara Takashi .  PAC1受容体の新規小分子拮抗薬はマウスにおけるホルマリンによる炎症性疼痛行動を軽減する(The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice) .  Journal of Pharmacological Sciences139 ( 2 ) 129 - 132   2019.2PAC1受容体の新規小分子拮抗薬はマウスにおけるホルマリンによる炎症性疼痛行動を軽減する(The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice)

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    Publisher:(公社)日本薬理学会  

    新たに開発した下垂体アデニル酸シクラーゼ活性化ポリペプチド(PACAP)タイプ1(PAC1)受容体の新規小分子拮抗薬PA-8について、マウスのホルマリンによる炎症性疼痛に対して有効か調べた。PA-8の髄腔内投与および経口投与は、ホルマリン誘発性侵害受容反応の第2相を用量依存的に減弱させた。PA-8は、脊髄の同側後角におけるc-fos上方制御も阻害した。以上より、脊髄におけるPACAP-PAC1受容体シグナル伝達系が主に炎症性疼痛の伝達に関与し、PA-8は炎症性疼痛を治療するための新規鎮痛薬の開発に有用と考えられた。

  • Takasaki I. .  The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice .  Journal of Pharmacological Sciences139 ( 2 ) 129 - 132   2019.2

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    Publisher:Journal of Pharmacological Sciences  

    DOI: 10.1016/j.jphs.2018.11.011

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  • Takasaki I. .  In silico screening identified novel small-molecule antagonists of PAC1 receptors .  Journal of Pharmacology and Experimental Therapeutics365 ( 1 ) 1 - 8   2018.4

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    Publisher:Journal of Pharmacology and Experimental Therapeutics  

    DOI: 10.1124/jpet.117.245415

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  • Kambe Yuki, Kurihara Takashi, Miyata Atsuro .  Astrocyte-neuron lactate shuttle, the major effector of astrocytic PACAP signaling for CNS functions .  Folia Pharmacologica Japonica151 ( 6 ) 239 - 243   2018

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    Publisher:The Japanese Pharmacological Society  

    <p>Transfer of lactate from astrocytes to neurons is activated when synaptic activity is increased, and this mechanism is now known as the astrocyte-neuron lactate shuttle (ANLS), that could account for the coupling between synaptic activity and energy delivery. Many lines of evidence suggested that ANLS contributes to neuronal activation or synaptic plasticity at the cellular level as well as learning/memory and cocaine addiction at the behavioral level. However, the candidate neurotransmitters which evoke ANLS activation are still under discussion. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neurotransmitter which distributed widely in central nervous system. Since PACAP might activate ANLS from very low concentration in cultured forebrain astrocytes, PACAP might be one of the candidates for the endogenous ANLS activator. In the present study, we investigated the potential relevance of PACAP/ANLS signaling in the learning/memory and spinal nociceptive transmission. In this study, we made the following findings: 1) PACAP could be an endogenous inducer for ANLS activation in central nervous system; 2) ANLS activation by PACAP/PAC1 receptor signaling contributed to learning/memory and induced long-lasting nociceptive behaviors; 3) PKC activation played an important role in the PACAP/PAC1 receptor-evoked ANLS.</p>

    DOI: 10.1254/fpj.151.239

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  • Aizawa Fuka, Ogaki Yoshihiro, Kyoya Natsuki, Nishinaka Takashi, Nakamoto Kazuo, Kurihara Takashi, Hirasawa Akira, Miyata Atsuro, Tokuyama Shogo .  GPR40/FFAR1シグナル伝達の欠損は雌性マウスの母性保護と感情機能に損傷を与える(The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice) .  Biological & Pharmaceutical Bulletin40 ( 8 ) 1255 - 1259   2017.8GPR40/FFAR1シグナル伝達の欠損は雌性マウスの母性保護と感情機能に損傷を与える(The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice)

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    遊離脂肪酸受容体1(GPR40/FFAR1)シグナル伝達の欠損に起因する母性および/または感情行動の変化を調べた。野生型(WT)雌性マウスと比較して、GPR40/FFAR1欠損(FFAR1-/-)雌性マウスでは、回収行動や無視および仔殺しの発生率の上昇など、母性保護の障害が見られた。FFAR1-/-雌性マウスは、高架式十字迷路試験でのオープンアームで費やされる時間の増加、運動活性や社会的相互作用行動の低下およびショ糖摂取の減少を示した。以上より、PUFA-GPR40/FFAR1シグナル伝達が、少なくとも部分的にマウスの感情的および母性的行動の調節因子として機能すると考えられた。

  • Nakamoto K. .  Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice .  PLoS ONE12 ( 7 ) e0180610   2017.7

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  • Minomo H. .  Establishment of disseminated intravascular coagulation (DIC) model by a single iv administration of Escherichia coli-derived lipopolysaccharide (LPS) to cynomolgus monkeys and evaluation of its pathophysiological status .  Journal of Pharmacological Sciences133 ( 2 ) 88 - 95   2017.2

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    Publisher:Journal of Pharmacological Sciences  

    DOI: 10.1016/j.jphs.2017.01.005

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  • Minomo Hirofumi, Inoue Kengo, Sakaki Shuko, Okazaki Takanobu, Kobayashi Kinji, Inoue Kazuhiko, Miyata Atsuro .  大腸菌由来リポ多糖類(LPS)のカニクイザルへの単回静脈内投与による播種性血管内凝固(DIC)モデルの確立とその病態生理学的状態の評価(Establishment of disseminated intravascular coagulation(DIC) model by a single iv administration of Escherichia coli-derived lipopolysaccharide(LPS) to cynomolgus monkeys and evaluation of its pathophysiological status) .  Journal of Pharmacological Sciences133 ( 2 ) 88 - 95   2017.2大腸菌由来リポ多糖類(LPS)のカニクイザルへの単回静脈内投与による播種性血管内凝固(DIC)モデルの確立とその病態生理学的状態の評価(Establishment of disseminated intravascular coagulation(DIC) model by a single iv administration of Escherichia coli-derived lipopolysaccharide(LPS) to cynomolgus monkeys and evaluation of its pathophysiological status)

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    カニクイザルにLPSを投与してDICモデルを作成し、DIC治療の新薬の評価に役立つか検討した。カニクイザルの末梢血単核細胞(PBMC)を8種類のLPSで処理し、TNF-α濃度を測定したところ、大腸菌K-235からのLPSが最も効果的にTNF-αを上昇させた。K-235のLPSをカニクイザルに静脈内投与すると、ヒトのPBMCと同様にTNF-α産生を促進させたが、ラットのPBMCへの作用は弱かった。カニクイザルにK-235のLPSを単回静脈内投与したところ、ヒトのDICと同じような病態生理学的変化が、肝臓、腎臓と肺に認められた。この時にDIC治療の新薬である組換えヒトトロンボモジュリンを投与したところ、これらの変化が抑制された。以上より、このDICモデルは、DIC治療のための新薬の評価に有用であると考えられた。

  • Kambe Yuki, Miyata Atsuro .  Possible roles of mitochondrial dysfunctions and <i>SIRT1</i> in major depressive disorder .  Folia Pharmacologica Japonica150 ( 4 ) 204 - 206   2017

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    Publisher:The Japanese Pharmacological Society  

    DOI: 10.1254/fpj.150.204

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  • Aizawa Fuka, Ogaki Yoshihiro, Kyoya Natsuki, Nishinaka Takashi, Nakamoto Kazuo, Kurihara Takashi, Hirasawa Akira, Miyata Atsuro, Tokuyama Shogo .  The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice .  Biological & Pharmaceutical Bulletin40 ( 8 ) 1255 - 1259   2017

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    Publisher:公益社団法人 日本薬学会  

    <p>The free fatty acid receptor 1 (GPR40/FFAR1) is activated by polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acids (DHA). This receptor has been the focus of many studies regarding physiological functions of the central nervous system. PUFAs are essential for neuronal development and maintenance of neuronal function; thus, the decrease of PUFAs in the brain is closely related to the induction of psychiatric diseases associated with emotional disorder, such as anxiety, depression, and schizophrenia. However, details of the mechanisms remain unclear. In this study, we investigated changes of maternal and/or emotional behavior caused by a deficiency of GPR40/FFAR1 signaling. GPR40/FFAR1 deficient (FFAR1<sup>−/−</sup>) female mice exhibited impaired maternal care such as retrieving behaviors and an increased rate of neglect and infanticide when compared to wild type (WT) female mice. Furthermore, FFAR1<sup>−/−</sup> female mice showed increased time spent in the open arms in an elevated plus maze test, reduction of locomotor activity and social interaction behavior, and decreased sucrose intake, when compared to WT female mice. In conclusion, these findings suggest that PUFAs-GPR40/FFAR1 signaling might function, at least in part, as a regulatory factor of emotional and maternal behavior in mice.</p>

    DOI: 10.1248/bpb.b17-00082

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Books

  • 脳と下垂体アデニル酸シクラーゼ活性化ペプチド(PACAP)

    宮田 篤郎( Role: Sole author)

    脳とホルモン(松尾壽之編)・共立出版  2005.9 

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    Language:Japanese Book type:Scholarly book

  • ベッドサイドの薬理学

    笹栗 俊之, 宮田 篤郎

    丸善出版  2018  ( ISBN:9784621302743

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MISC

  • Chronic royal jelly administration induced antidepressant-like effects through increased sirtuin1 and oxidative phosphorylation protein expression in the amygdala of mice

    Nguyen T.T.

    Current Molecular Pharmacology   14 ( 2 )   115 - 122   2021

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    Language:Japanese   Publisher:Current Molecular Pharmacology  

    Background: Major depressive disorder (MDD) is a common psychological disorder worldwide. However, one-third of patients with MDD are resistant to the present anti-depressant medicine, which regulates monoamine contents in the brain. Thus, another drug target is strongly required. Much evidence strongly suggests that sirtuin1, which is the key factor in regulating the mitochondrial activity, may be implicated in MDD. Objective: Since it is suggested that royal jelly (RJ) ameliorated depressive-like behavior and affected mitochondrial activity in mice, we hypothesized that RJ could be an alternative medicine against MDD, which acts via sirtuin1 signaling to improve mitochondrial activity. Methods: In the present study, we applied a mouse model of MDD to investigate the effect of RJ on the depressive-like behavior and the sirtuin1 signaling on mitochondrial activity. Results: Our results indicated that either the oral administration of RJ for 12 days or single intracerebroventricular (i.c.v.) injection decreased the duration of immobility in the tail suspension test, which suggested that RJ had an antidepressant-like effect. Moreover, sirtuin1 protein expression increased in mice following RJ treatment in the amygdala region, but not in the other brain regions. Similarly, the expressions of oxidative phosphorylation (OXPHOS) related proteins increased in the amygdala regions, but not in the hippocampal regions. Conclusion: The increase of sirtuin1 and OXPHOS protein expression may at least in part contribute to the antidepressant-like effect of the RJ pathway, and RJ may have the potential to be a novel anti-depressant drug.

    DOI: 10.2174/1874467213666200424160153

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  • VIP/PACAPと関連疾患

    宮田篤郎、國師恵美子

    医薬ジャーナル   47 ( 8 )   111 - 115   2011.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳腸ペプチドとしてのPACAPの構造と機能

    宮田篤郎

    医学のあゆみ   223 ( 7 )   569 - 572   2007.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 多機能神経ペプチドPACAP受容体の構造と機能の多様性

    宮田篤郎、牛山美奈、菅原英輝

    内分泌糖尿病科・科学評論社   22 ( 4 )   421 - 428   2006

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • PACAPと血小板機能

    宮田篤郎

    血栓と循環・メディカルレヴュー   13 ( 2 )   44 - 46   2005.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • リゾホスファチジルコリンと血管内皮機能

    井上和彦、宮田篤郎

    血管・脈管作動物質学会   28 ( 4 )   139 - 143   2005.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • PACAP遺伝子の神経特異的発現調節機序

    宮田篤郎、菅原英輝、岩田真一、清水隆雄、寒川賢治

    日本薬理学会誌・日本薬理学会   123   235 - 242   2004

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【PACAPシグナル研究の新潮流〜中枢・末梢組織での新しい生理・病態的意義〜】PACAPシグナリングによって駆動されるアストロサイト ニューロン乳酸シャトルの中枢神経機能発現への寄与

    神戸 悠輝, 栗原 崇, 宮田 篤郎

    日本薬理学雑誌   151 ( 6 )   239 - 243   2018.6

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    アストロサイト-ニューロン乳酸シャトル(ANLS)は、アストロサイトを含むグリア細胞が産生した乳酸をニューロンが利用することを仮定したモデルである。ANLSは近年、学習・記憶、薬物依存などに重要な役割を果たし、細胞レベルにおいても、ニューロンを直接活性化したり、シナプス促通を惹起したりすることが報告されている。しかしながら、どのようなシグナルがアストロサイトに作用し、ANLSを活性化するか明らかではなかった。一方、神経ペプチド、下垂体アデニル酸シクラーゼ活性化ポリペプチド(PACAP)とその受容体は、中枢神経系に広く分布する。我々は前脳由来培養アストロサイトにおいて、PACAPは非常に低い濃度からANLSを活性化する可能性を見出したことから、内因性のANLS活性化因子の候補としてPACAPを捉え、恐怖記憶、脊髄痛覚伝達に対する関与を検討した。その結果、PACAPは少なくとも前脳と脊髄のアストロサイトのPACAP/PAC1シグナルの下流においてPKCを介したANLSの活性化を惹起し、恐怖記憶および脊髄痛覚伝達に関与することが明らかとなった。以上の結果から、PACAPは内因性のANLS活性化因子である可能性が示された。(著者抄録)

  • キーワード解説 大うつ病性障害におけるミトコンドリア機能障害とサーチュイン1の関与

    神戸 悠輝, 宮田 篤郎

    日本薬理学雑誌   150 ( 4 )   204 - 206   2017.10

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    Publisher:(公社)日本薬理学会  

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Presentations

  • 栗原崇、福留学、宮田篤郎、結城伸泰   有痛性神経障害患者血清のマウスへの受動的移入による疼痛様行動再現の試み   International conference

    第88回日本薬理学会年会  第88回日本薬理学会年会

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    Event date: 2015.3

    Language:English  

    Venue:名古屋  

    国際学会

  • 用皆正文、栗原崇、神戸悠輝、高崎一郎、宮田篤郎   脊髄におけるPACAP特異的受容体の刺激はアストロサイト活性化を介して長期機械的アロディニア反応を誘発する  

    第88回日本薬理学会年会  第88回日本薬理学会年会

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    Event date: 2015.3

    Language:Japanese  

    Venue:名古屋  

    国内学会

  • 神戸悠輝、中島優、新谷紀人、橋本均、宮田篤郎   培養アストロサイトにおける下垂体アデニル酸シクラーゼ活性化ポリペプチドによるグリコーゲン代謝の活性化  

    第88回日本薬理学年会  第88回日本薬理学年会

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    Event date: 2015.3

    Language:Japanese  

    Venue:名古屋  

    国内学会

  • 井上和彦、竹ノ内里奈、國師恵美子、大和麻耶、神戸悠輝、宮田篤郎   下垂体腺腫細胞GH3のプロラクチンおよび成長ホルモン分泌に及ぼすリゾホスファチジルセリンの効果  

    第67回日本薬理学会西南部会  第67回日本薬理学会西南部会

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    Event date: 2014.11

    Language:Japanese  

    Venue:北九州市  

    国内学会

  • 福留学、井上隆之、宮田篤郎、結城伸泰、栗原崇   有痛性神経障害患者血清のマウスへの受動態移入による疼痛様行動の再現   International conference

    第67回日本薬理学会西南部会  第67回日本薬理学会西南部会

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    Event date: 2014.11

    Language:English  

    Venue:北九州市  

    国際学会

  • 神戸悠輝、宮田篤郎   下垂体アデニル酸シクラーゼ活性化ポリペプチドによる脳内グリコーゲン代謝の活性化~培養アストロサイトを用いた研究~  

    第67回日本薬理学会西南部会  第67回日本薬理学会西南部会

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    Event date: 2014.11

    Language:Japanese  

    Venue:北九州市  

    国内学会

  • Youkai M, Kurihara T, Asada T, Kambe Y, Inoue K, Miyata A   Spinal PACAP-PAC1-receptor signaling pathway induces long-lasting mechanical allodynia through the activation of astrocytes in mice   International conference

    Society for Neuroscience 2014  Society for Neuroscience 2014

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    Event date: 2014.11

    Language:English  

    Venue:ワシントン  

    国際学会

  • 宮田篤郎、三浦綾子、神戸悠輝、辰川英樹、栗原崇、小嶋聡一   脳虚血におけるPAC1遺伝子発現の抑制メカニズム  

    第11回GPCR研究会  第11回GPCR研究会

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    Event date: 2014.5

    Language:Japanese  

    Venue:東京  

    国内学会

  • Miyata A, Miura A, Kambe Y, Kojima S   Cross-linking of SP1 by transglutaminase2 suppresses PAC1 gene expression in neuronal cells.  

    第36回日本分子生物学会年会  第36回日本分子生物学会年会

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    Event date: 2014.1

    Language:Japanese  

    Venue:神戸  

    国内学会

  • 宮田篤郎   Cross-linking of Sp1 by transglutaminase2 suppresses PAC1 gene expression in neuronal cells   International conference

    11th International Symposium on VIP, PACAP and related peptides  11th International Symposium on VIP, PACAP and related peptides

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    Event date: 2013.8

    Language:English  

    Venue:ハンガリー,ペーチ市  

    国際学会

  • 宮田篤郎、ボハラ マノズ、神戸悠輝、栗原 崇、時村 洋、有田 和徳   Cタイプナトリウム利尿ペプチドは、血液脳関門の透過性制御に関与する  

    第86回日本薬理学会年会  第86回日本薬理学会年会

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 三浦綾子、神戸悠輝、井上和彦、栗原 崇、辰川英樹、小嶋聡一、宮田篤郎   PAC1遺伝子の負の発現調節にトランスグルタミナーゼ2によるSp1の不活性化が関与する  

    第86回日本薬理学会年会  第86回日本薬理学会年会

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 栗原 崇、カルキ プラサンナ、朝田俊秀、吉村惠、有田和徳、宮田篤郎   マウス炎症疼痛および神経障害性疼痛モデルにおける遊離脂肪酸受容体GPR40作動薬の効果  

    第86回日本薬理学会年会  第86回日本薬理学会年会

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    Event date: 2013.3

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 三浦綾子、神戸悠輝、井上和彦、栗原崇、辰川英樹、小嶋聡一、宮田篤郎   PAC1遺伝子の負の発現調節はトランスグルタミナーゼ2によるSp1の不活性化が関与する  

    第85回日本生化学会大会  第85回日本生化学会大会

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    Event date: 2012.12

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 用皆正文、大脳哲也、栗原 崇、長谷川麻衣子、朝田俊秀、上村裕一、清水隆雄、宮田篤郎   PACAP誘発長期疼痛行動の発症メカニズム-PACAP-PAC1受容体シグナルによる早期脊髄後角アストロサイト活性化の関与  

    第65回日本薬理学会西南部会  第65回日本薬理学会西南部会

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    Event date: 2012.11

    Language:Japanese  

    Venue:熊本  

    国内学会

  • 川元大輔、喜井 勲、豊本雅靖、朝田俊秀、吉村 惠、萩原正敏、宮田篤郎   炎症性疼痛モデルマウスに対する新規カゼインキナーゼ阻害薬の抗侵害効果  

    第65回日本薬理学会西南部会  第65回日本薬理学会西南部会

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    Event date: 2012.11

    Language:Japanese  

    Venue:熊本  

    国内学会

  • Miura A, Kambe Y, Inoue K, Kurihara T, Miyata A   Sp1 serves pivotal role in negative regulation of PAC1 gene expression by involvement of transglutaminase 2   International conference

    Society for Neuroscience 42th Annual Meeting  Society for Neuroscience 42th Annual Meeting

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    Event date: 2012.10

    Language:English  

    Venue:New Orleans, USA  

    国際学会

  • Kambe Y, Miyata A   Involvement of mitochondria in PACAP-induced neurite outgrowth   International conference

    Society for Neuroscience 42th Annual Meeting  Society for Neuroscience 42th Annual Meeting

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    Event date: 2012.10

    Language:English  

    Venue:New Orleans, USA  

    国際学会

  • Kurihara T, Karki P, Asada T, Nagayama.T, Yosimura M, Arita K, Miyata A   Role of free fatty acid receptor GPR40 in mouse models of inflammatory and neuropathic pain   International conference

    Society for Neuroscience 42th Annual Meeting  Society for Neuroscience 42th Annual Meeting

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    Event date: 2012.10

    Language:English  

    Venue:New Orleans, USA  

    国際学会

  • 栗原 崇、Prasannna Karki、朝田俊秀、吉村惠、宮田篤郎   脊髄痛覚伝達における脂肪酸受容体GPR40の役割  

    第35回日本神経科学大会  第35回日本神経科学大会

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    Event date: 2012.9

    Language:Japanese  

    Venue:名古屋  

    国内学会

  • 用皆正文、大納哲也、栗原 崇、長谷川麻衣子、朝田俊秀、上村裕一、清水隆雄、宮田篤郎   PACAP-PAC1受容体シグナルによる早期脊髄アストロサイト活性化は、PACAP誘発長期疼痛行動に寄与する  

    第6回トランスポーター研究会九州部会  第6回トランスポーター研究会九州部会

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    Event date: 2012.9

    Language:Japanese  

    Venue:福岡  

    研究会

  • 三浦綾子、神戸悠輝、井上和彦、栗原 崇、宮田篤郎   Neuro2a細胞におけるERストレスによるPAC1遺伝子の負の発現調節機序  

    第9回GPCR研究会  第9回GPCR研究会

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    Event date: 2012.5

    Language:Japanese  

    Venue:東京  

    研究会

  • 竹ノ内里奈、井上和彦、神戸悠輝、宮田篤郎   N-arachidonoyl glycineはGPR18を介してマクロファージのアポトーシスを誘導する  

    第9回GPCR研究会  第9回GPCR研究会

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    Event date: 2012.5

    Language:Japanese  

    Venue:東京  

    研究会

  • 朝田俊秀、プラサンナ・カルキ、吉村惠、宮田篤郎、栗原 崇   脊髄痛覚伝達におけるGPR40の役割  

    第9回GPCR研究会  第9回GPCR研究会

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    Event date: 2012.5

    Language:Japanese  

    Venue:東京  

    研究会

  • 神戸悠輝、宮田篤郎   ミトコンドリアを介したPACAPによる神経突起伸展促進作用  

    第9回GPCR研究会  第9回GPCR研究会

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    Event date: 2012.5

    Language:Japanese  

    Venue:東京  

    研究会

  • 竹ノ内里奈、井上和彦、神戸悠輝、栗原 崇、宮田篤郎   N-arachidonoyl glycine(NAGly)により誘導されるマクロファージのアポトーシスはGPR18を介している  

    第85回日本薬理学会年会  第85回日本薬理学会年会

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    Event date: 2012.3

    Language:Japanese  

    Venue:京都  

    国内学会

  • 栗原 崇、櫻井絵里、朝田俊秀、吉村 惠、宮田篤郎、田邊 勉   炎症性および神経因性疼痛におけるカゼインキナーゼ1の役割  

    第85回日本薬理学会年会  第85回日本薬理学会年会

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    Event date: 2012.3

    Language:Japanese  

    Venue:京都  

    国内学会

  • Miura A, Kambe Y, Inoue K, Kurihara T, Miyata A   SP1 is involved in not only positive but also negative expression of PAC1 gene   International conference

    The 10th International Symposium on VIP-PACAP and Related Peptides  The 10th International Symposium on VIP-PACAP and Related Peptides

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    Event date: 2011.12

    Language:English  

    Venue:エイラト、イスラエル  

    国際学会

  • Kambe Y, Inoue K, Kurihara T, Miyata A   Involvement of mitochondria in PACAP-PAC1 dependent neurite outgrowth   International conference

    The 10th International Symposium on VIP-PACAP and Related Peptides  The 10th International Symposium on VIP-PACAP and Related Peptides

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    Event date: 2011.12

    Language:English  

    Venue:Eilat, Israel  

    国際学会

  • 國師恵美子、竹ノ内里奈、大和麻耶、井上和彦、神戸悠輝、栗原 崇、宮田篤郎   リゾホスファチジルセリンのラット下垂体由来細胞における成長ホルモン分泌への促進効果に関する研究  

    薬物活性シンポジウム  薬物活性シンポジウム

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    Event date: 2011.11

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 栗原 崇、櫻井絵里、朝田俊秀、吉村 惠、宮田篤郎、田邊 勉   カゼインキナーゼ1δ/ε活性化は炎症性疼痛情報伝達に寄与する  

    日本薬理学会西南部会  日本薬理学会西南部会

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    Event date: 2011.11

    Language:Japanese  

    Venue:福岡  

    国内学会

  • Takenouchi R, Inoue K, Kambe Y, Kurihara T, Miyata A   Functional analysis of N-arachidonoylglycine as a novel anti-inflammatory factor in microglia   International conference

    Society for Neuroscience 41th Annual Meeting  Society for Neuroscience 41th Annual Meeting

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    Event date: 2011.11

    Language:English  

    Venue:Washington DC, USA  

    国際学会

  • 朝田俊秀、栗原 崇、櫻井絵里、吉村 惠、宮田篤郎、田邊 勉   炎症性疼痛情報伝達におけるカゼインキナーゼ1δ/ε活性化の関与  

    第5回トランスポーター研究会九州部会  第5回トランスポーター研究会九州部会

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    Event date: 2011.9

    Language:Japanese  

    Venue:宮崎  

    国内学会

  • 竹ノ内里奈、國師恵美子、大和麻耶、井上和彦、神戸悠輝、栗原 崇、宮田篤郎   Lysophosphatidylserineはラット下垂体由来細胞において成長ホルモン分泌を促進させる  

    第5回トランスポーター研究会九州部会  第5回トランスポーター研究会九州部会

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    Event date: 2011.9

    Language:Japanese  

    Venue:宮崎  

    国内学会

  • 神戸悠輝、井上和彦、栗原 崇、宮田篤郎   PACAPによる神経突起の形成過程におけるPgc1αの細胞内局在変化の関与  

    第54回日本神経化学会大会  第54回日本神経化学会大会

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    Event date: 2011.9

    Language:Japanese  

    Venue:石川  

    国内学会

  • 三浦綾子、井上和彦、神戸悠輝、栗原 崇、宮田篤郎   Neuro2a細胞におけるERストレスによるPAC1遺伝子の負の発現調節機序  

    第84回日本生化学会大会  第84回日本生化学会大会

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    Event date: 2011.9

    Language:Japanese  

    Venue:京都  

    国内学会

  • Yuki Kanbe, Kazuhiko Inoue, Takasi Kurihara, Atsuro Miyata   PGC1A translocation may be one of the key factors for neurite outgrowth in neurons   International conference

    11th Conference of Japanese Society of Mitochcondrial Reserch and Medicine(J-mit)  11th Conference of Japanese Society of Mitochcondrial Reserch and Medicine(J-mit)

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    Event date: 2011.8

    Language:English  

    Venue:鹿児島  

    国際学会

  • 三浦綾子、井上和彦、神戸悠輝、栗原 崇、宮田篤郎   PAC1遺伝子の負の発現調節機序の解析  

    第84回日本薬理学会年会  第84回日本薬理学会年会

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    Event date: 2011.3

    Language:Japanese  

    Venue:横浜  

    国内学会

  • 齊藤弘樹、井上和彦、池田龍二、中町友哉、塩田清二、永田さやか、北村和雄、南野直人、宮田篤郎   ラット骨芽細胞における増殖調節因子としてのニューロメディンBの生理的役割の解明  

    第84回日本薬理学会年会  第84回日本薬理学会年会

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    Event date: 2011.3

    Language:Japanese  

    Venue:横浜  

    国内学会

  • 神戸悠輝、井上和彦、栗原 崇、宮田篤郎   Neuro2a細胞の神経突起形成過程におけるPac1の細胞内輸送によるシグナル伝達機構の解明  

    第84回日本薬理学会年会  第84回日本薬理学会年会

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    Event date: 2011.3

    Language:Japanese  

    Venue:横浜  

    国内学会

  • 井上和彦、桐原みらい、竹ノ内里奈、神戸悠輝、栗原 崇、宮田篤郎   共役リノール酸受容体の同定  

    第83回日本生化学会大会  第83回日本生化学会大会

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    Event date: 2010.12

    Language:Japanese  

    国内学会

  • 三浦綾子、富永愛子、井上和彦、神戸悠輝、栗原 崇、宮田 篤郎   PC12細胞におけるERストレスによるPAC1遺伝子の負の発現調節機序  

    第63回日本薬理学会西南部会  第63回日本薬理学会西南部会

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    Event date: 2010.11

    Language:Japanese  

    Venue:鹿児島  

    国内学会

  • 新川純平、神戸悠輝、井上和彦、栗原 崇、武田泰生、山田勝士、宮田篤郎   中枢神経への高脂肪食の影響に関与する受容体の解析  

    第63回日本薬理学会西南部会  第63回日本薬理学会西南部会

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    Event date: 2010.11

    Language:Japanese  

    Venue:鹿児島  

    国内学会

  • Ayako Miura・Aiko Tominaga・Kazuhiko Inoue・Atsuro Miyata   NGF induced PAC1 gene is essential for neuroprotection of PACAP in PC12 cellsRegulatory mechanism of PAC1 gene expression by nerve growth factor (NGF) in PC12 cells   International conference

    Society for Neuroscience 40rd Annual Meeting  Society for Neuroscience 40rd Annual Meeting

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    Event date: 2010.11

    Language:English  

    Venue:米国  

    国際学会

  • Yuki Kambe,Atsuro Miyata   From mitochondria to nucleus,Pgc1 translocation may be one of the key factors for neurite extension in N2a cells.   International conference

    Society for Neuroscience 40rd Annual Meeting  Society for Neuroscience 40rd Annual Meeting

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    Event date: 2010.11

    Language:English  

    Venue:米国  

    国際学会

  • Miyata A, Ikeda K, Inoue K, Kurihara T, Shimizu T   Implication of pituitary adenylate cyclase-activating polypeptide (PACAP) in diabetic neuropathy of streptozotocin (STZ) treated mice   International conference

    The 20th Japan-Korea Joint Seminar on Pharmacology  The 20th Japan-Korea Joint Seminar on Pharmacology

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    Event date: 2010.11

    Language:English  

    Venue:Kagoshima, JAPAN  

    国際学会

  • 宮田篤郎   多機能神経ペプチドPACAPの精巣特異的機能発現  

    第28回内分泌代謝学サマーセミナー  第28回内分泌代謝学サマーセミナー

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    Event date: 2010.7

    Language:Japanese  

    国内学会

  • 宮田篤郎、大納哲也、坂本光、井上和彦、池田圭吾、清水隆雄   痛覚伝達におけるPACAP特異的受容体PAC1の役割  

    第7回GPCR研究会  第7回GPCR研究会

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    Event date: 2010.5

    Language:Japanese  

    Venue:東京  

    国内学会

  • 三浦綾子、小田原尚子、富永愛子、神戸悠輝、井上和彦、宮田篤郎   PC12細胞において神経保護作用を示すPAC1受容体遺伝子発現におけるNGFの関与  

    第7回GPCR研究会  第7回GPCR研究会

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    Event date: 2010.5

    Language:Japanese  

    Venue:東京  

    国内学会

  • 竹ノ内里奈、井上和彦、宮田篤郎   マクロファージにおけるリポアミノ酸によるアポトーシス誘導  

    第7回GPCR研究会  第7回GPCR研究会

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    Event date: 2010.5

    Language:Japanese  

    Venue:東京  

    国内学会

  • 竹ノ内里奈、井上和彦、宮田篤郎   マクロファージにおけるリポアミノ酸によるアポトーシス誘導  

    第62回日本薬理学会西南部会  第62回日本薬理学会西南部会

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    Event date: 2009.11

    Language:Japanese  

    Venue:愛媛  

    国内学会

  • Hiroki Saito, Ryuichi Ikeda, Kazuhiko Inoue, Atsuro Miyata   Neuromedin B stimulates Proliferation of Rat Calvarial Osteoblasts through ERK Signaling Pathway   International conference

    Satellte Symposium of 9th International Symposium on VIP,PACAP and Related Peptides  Satellte Symposium of 9th International Symposium on VIP,PACAP and Related Peptides

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    Event date: 2009.10

    Language:English  

    Venue:Yakushima, Kagoshima, JAPAN  

    国際学会

  • 竹ノ内里奈、井上和彦、宮田篤郎   リポアミノ酸によるアポトーシス誘導機序の解明  

    第82回日本生化学会大会  第82回日本生化学会大会

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    Event date: 2009.10

    Language:Japanese  

    Venue:神戸  

    国内学会

  • 井上和彦、宮田篤郎   遊離脂肪酸受容体の新機能 ~敗血症における役割~  

    第82回日本生化学会大会  第82回日本生化学会大会

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    Event date: 2009.10

    Language:Japanese  

    Venue:神戸  

    国内学会

  • Ayako Miura, Odahara Naoko, Aiko Tominaga, Kazuhiko Inoue, Atsuro Miyata   Regulatory mechanism of PACAP1 gene expression by nerve growth factor(NGF) in PC12 cells   International conference

    The 9th International Symposium on VIP,PACAP and Related Peptides  The 9th International Symposium on VIP,PACAP and Related Peptides

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    Event date: 2009.10

    Language:English  

    Venue:鹿児島  

    国際学会

  • Hideki Sugawara, Aiko Tominaga, Katsushi Yamada, Atsuro Miyata   The alternative regulation of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression by neural-restrictive silencer   International conference

    The 9th International Symposium on VIP,PACAP and Related Peptides  The 9th International Symposium on VIP,PACAP and Related Peptides

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    Event date: 2009.10

    Language:English  

    Venue:鹿児島  

    国際学会

  • Aiko Tominaga, Mina Ushiyama, Hideki Sugawara, Kazuhiko Inoue, Hiroshi Hanada, Atsuro Miyata   The cell-speciffic promoter in upstream region of human PACAP testis-speciffic exon   International conference

    The 9th International Symposium on VIP,PACAP and Related Peptides  The 9th International Symposium on VIP,PACAP and Related Peptides

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    Event date: 2009.10

    Language:English  

    Venue:鹿児島  

    国際学会

  • Mina Ushiyama, Ryuji Ikeda, Hideki Sugawara, Kazuhiko Inoue, Kenji Kangawa, Katsuhi Yamada, and Atsuro Miyata   Alternative splicing of the pituitary adenylate cyclase-activating polypetide (PACAP) receptor contribute to function of PACAP-27   International conference

    The 9th International Symposium on VIP,PACAP and Related Peptides  The 9th International Symposium on VIP,PACAP and Related Peptides

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    Event date: 2009.10

    Language:English  

    Venue:鹿児島  

    国際学会

  • 桐原みらい、井上和彦、宮田篤郎   共益リノール酸(conjugated linoleic acid; CLA)は長鎖脂肪酸受容体に結合するのか?  

    第83回日本薬理学会年会  第83回日本薬理学会年会

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    Event date: 2009.3

    Language:Japanese  

    Venue:大阪  

    国内学会

  • 三浦綾子、小田原尚子、富永愛子、井上和彦、宮田篤郎   PC12細胞において神経保護作用を示すPAC1受容体遺伝子発現におけるNGFの関与   International conference

    第83回日本薬理学会年会  第83回日本薬理学会年会

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    Event date: 2009.3

    Language:English  

    Venue:大阪  

    国際学会

  • Keigo Ikeda, Takao Shimizu, Makiko Yokoi, Kazuhiko Inoue, Atsuro Miyata   Involvement of pituitary adenylate cyclase-activating polypeptide (PACAP) in deabetic neuropathy of streptozotocin (STZ) treated mice   International conference

    17th International Symposium on Regulatory Peptides  17th International Symposium on Regulatory Peptides

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    Event date: 2009.1

    Language:English  

    Venue:Santa Barbara, CA, USA  

    国際学会

  • Atsuro Miyata, Mina Ushiyama, Kazuhiko Inoue, Hideki Sugawara and Kenji Kangawa   The significance of multiple molecular forms of PAC1 as the basis for fnctional diversity of PACAP   International conference

    THE 9th Neuropepide Y International Meeting  THE 9th Neuropepide Y International Meeting

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    Event date: 2008.3

    Language:English  

    Venue:OKINAWA  

    国際学会

  • 宮田篤郎、菅原英輝、井上和彦、寒川賢治   多機能神経ペプチド PACAPの神経特異的発現調節機序の解明  

    第34回 日本心脈管作動物質学会  第34回 日本心脈管作動物質学会

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    Event date: 2005.2

    Language:Japanese  

    Venue:京都  

    国内学会・一般講演

  • 富士川浩祥、永山哲也、井上和彦、南野直人、寒川賢治、新納正毅、宮田篤郎   Pituitary adenylate cyclase activating polypeptide (PACAP) はC-type natriuretic peptide (CNP) の生合成・分泌を促進する  

    第77回日本内分泌学会学術総会  第77回日本内分泌学会学術総会

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    Event date: 2004.6

    Language:Japanese  

    Venue:京都  

    国内学会・一般講演

  • 牛山美奈、菅原英輝、井上和彦、山田勝士、宮田篤郎   マウス心臓に発現するPACAP特異的受容体PAC1バリアントの機能解析  

    第1回 GPCR研究会  第1回 GPCR研究会

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    Event date: 2004.5

    Language:Japanese  

    Venue:東京  

    研究会・一般講演

  • 菅原英輝、井上和彦、森 望、寒川賢治、山田勝士、宮田篤郎   神経選択的サイレンサーによるPACAP遺伝子の発現調節機序の解析  

    平成16年度日本生化学会九州支部例会  平成16年度日本生化学会九州支部例会

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    Event date: 2004.5

    Language:Japanese  

    Venue:熊本  

    国内学会・一般講演

  • 吉野 紀美香, 飯笹 栄一, 原 博満, 栗原 崇, 宮田 篤郎   脊髄損傷霊長類モデルを用いた自律神経回路再編による免疫機構破綻メカニズムの解明  

    日本自律神経学会総会プログラム・抄録集  2021.10  日本自律神経学会

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    Language:Japanese  

  • 橋口 浩平, 神戸 悠輝, 杉村 光隆, 栗原 崇, 宮田 篤郎   次世代の若手研究者が切り開く薬学研究の発展と医療への貢献 PACAPは視床下部室傍核において末梢神経障害性疼痛に伴う不安様行動発現に寄与する  

    日本薬学会年会要旨集  2021.3  (公社)日本薬学会

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    Language:Japanese  

  • 吉野 紀美香, 飯笹 栄一, 原 博満, 栗原 崇, 宮田 篤郎   脊髄損傷霊長類モデルを用いた自律神経回路再編による免疫機構破綻メカニズムの解明  

    日本自律神経学会総会プログラム・抄録集  2021.10  日本自律神経学会

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  • 橋口 浩平, 神戸 悠輝, 杉村 光隆, 栗原 崇, 宮田 篤郎   次世代の若手研究者が切り開く薬学研究の発展と医療への貢献 PACAPは視床下部室傍核において末梢神経障害性疼痛に伴う不安様行動発現に寄与する  

    日本薬学会年会要旨集  2021.3  (公社)日本薬学会

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    Language:Japanese  

  • 吉野 紀美香, 飯笹 栄一, 原 博満, 栗原 崇, 宮田 篤郎   脊髄損傷霊長類モデルを用いた自律神経回路再編による免疫機構破綻メカニズムの解明  

    日本自律神経学会総会プログラム・抄録集  2021.10  日本自律神経学会

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    Language:Japanese  

  • 橋口 浩平, 神戸 悠輝, 杉村 光隆, 栗原 崇, 宮田 篤郎   次世代の若手研究者が切り開く薬学研究の発展と医療への貢献 PACAPは視床下部室傍核において末梢神経障害性疼痛に伴う不安様行動発現に寄与する  

    日本薬学会年会要旨集  2021.3  (公社)日本薬学会

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    Language:Japanese  

  • Kurihara Takashi, Fujii Kazuyasu, Uchida Youhei, Terawaki Tomomi, Saito Hiroki, Kato Sho, Ikeda Ryuta, Murata Mayuko, Kambe Yuki, Miyata Atsuro, Takasaki Ichiro, Kanekura Takuro   マウスの痒み感覚における中枢および末梢のPACAP-PAC1受容体シグナル伝達の関与(Possible contribution of both central and peripheral PACAP-PAC1 receptor signaling to itch sensation in mice)  

    日本研究皮膚科学会年次学術大会・総会プログラム  2022.10  (一社)日本研究皮膚科学会

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  • 神戸 悠輝, 栗原 崇, 宮田 篤郎   視床下部腹内側核PACAPによる神経ペプチドネットワークを介した摂食行動の調節  

    日本内分泌学会雑誌  2022.4  (一社)日本内分泌学会

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  • 中本 賀寿夫, 相澤 風花, 山下 琢矢, 万倉 三正, 小山 豊, 糟谷 史代, 平澤 明, 栗原 崇, 宮田 篤郎, 徳山 尚吾   長鎖脂肪酸受容体GPR40/FFAR1の欠損は痛みを増強する  

    日本神経精神薬理学雑誌  2017.6  (一社)日本神経精神薬理学会

  • 中本 賀寿夫, 大垣 圭弘, 相澤 風花, 山下 琢矢, 平澤 明, 栗原 崇, 宮田 篤郎, 徳山 尚吾   長鎖脂肪酸受容体GPR40/FFAR1の欠損は、情動行動異常を示す  

    日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集  2017.9  日本生物学的精神医学会・日本神経精神薬理学会

  • 高崎 一朗, 豊岡 尚樹, 宮田 篤郎, 合田 浩明, 栗原 崇   脳・神経系疾患の薬物治療を革新する異分野連携シンポジウム 基礎研究で考えることとは? 難治性疼痛治療を目指した新規PAC1受容体小分子アンタゴニストの創薬  

    日本薬学会年会要旨集  2019.3  (公社)日本薬学会

  • 下平 文香, 長島 涼太, 渡辺 藍, 岡田 卓哉, 豊岡 尚樹, 合田 浩明, 宮田 篤郎, 栗原 崇, 高崎 一朗   脊髄神経結紮モデルマウスの疼痛反応に対する新規PAC1受容体拮抗薬の効果  

    日本薬学会年会要旨集  2018.3  (公社)日本薬学会

  • 中本 賀寿夫, 相澤 風花, 山下 琢矢, 平澤 明, 栗原 崇, 宮田 篤郎, 糟谷 史代, 徳山 尚吾   疼痛時における脳内遊離脂肪酸の変化  

    PAIN RESEARCH  2017.6  (一社)日本疼痛学会

  • Iso Serina, Takahara Satoyuki, Gouda Hiroaki, Miyata Atsuro, Kurihara Takashi, Toyooka Naoki, Takasaki Ichiro   新規鎮痛薬のドラッグディスカバリーを目的とした核内受容体Nr4a1に対する新たなアンタゴニストの開発(Development of new antagonist for nuclear receptor Nr4a1 aimed at drug discovery of new analgesics)  

    Journal of Pharmacological Sciences  2017.3  (公社)日本薬理学会

  • Bureta Costansia Anselim, Kurihara Takashi, Saitoh Yoshinobu, Tokumoto Hiroto, Tominaga Hiroyuki, Maeda Shingo, Nagano Satoshi, Miyata Atsuro, Komiya Setsuro, Taniguchi Noboru, Setoguchi Takao   損傷した神経節においてtransforming growth factor-βは小膠細胞の増殖を促進する(Transforming growth factor beta promotes proliferation of microglia in injured ganglions)  

    Journal of Spine Research  2019.3  (一社)日本脊椎脊髄病学会

  • 上田 隆拡, 長島 涼太, 渡辺 藍, 岡田 卓哉, 豊岡 尚樹, 高崎 一朗, 栗原 崇, 宮田 篤郎   抗がん剤(Oxaliplatin)誘発性末梢神経障害における新規PAC1受容体アンタゴニストの効果  

    日本薬学会年会要旨集  2018.3  (公社)日本薬学会

  • 宮田 篤郎, 中島 優, 栗原 崇, 神戸 悠輝   恐怖記憶の獲得と想起にはPACAPを介したアストロサイト-ニューロン乳酸シャトルが関与する  

    日本内分泌学会雑誌  2019.4  (一社)日本内分泌学会

  • Nagashima Ryota, Ueda Takahiro, Watanabe Ai, Okada Takuya, Kurihara Takashi, Miyata Atsuro, Toyooka Naoki, Takasaki Ichiro   各種マウス疼痛モデルにおける新規PAC1受容体アンタゴニストの薬理学的評価(Pharmacological evaluation of novel PAC1 receptor antagonist in various pain models of mice)  

    Journal of Pharmacological Sciences  2017.3  (公社)日本薬理学会

  • 神戸 悠輝, Nguyen Thanh Trung, 宮田 篤郎   マウスのうつ様行動におけるミトコンドリア変性タンパク質ストレスレスポンスの関与  

    日本薬学会年会要旨集  2018.3  (公社)日本薬学会

  • 高崎 一朗, 岡田 健斗, 柴崎 千華, 下平 文香, 岡田 卓哉, 豊岡 尚樹, 合田 浩明, 宮田 篤郎, 栗原 崇   ニトログリセリン誘発片頭痛モデルマウスの疼痛関連行動におよぼす新規PAC1受容体アンタゴニストの効果  

    PAIN RESEARCH  2019.7  (一社)日本疼痛学会

  • Kambe Yuki, Yokai Masafumi, Nakashima Yu, Shintani Norihito, Hashimoto Hitoshi, Takasaki Ichiro, Kurihara Takashi, Miyata Atsuro   アストロサイト-ニューロン乳酸シャトル CNS機能におけるアストロサイトPACAPシグナル伝達の主要なエフェクター(Astrocyte-neuron lactate shuttle, the major effector of astrocytic PACAP signaling for CNS functions)  

    Journal of Pharmacological Sciences  2017.3  (公社)日本薬理学会

  • Ohki Saori, Kambe Yuki, Okutsu Kayu, Yoshizaki Yumiko, Takamine Kazunori, Miyata Atsuro   Raw264細胞でpalmitic acidが誘導する炎症に対する白麹の阻害活性(The inhibitory activity of white koji against the palmitic acid-induced inflammation on Raw264 cells)  

    Journal of Pharmacological Sciences  2017.3  (公社)日本薬理学会

  • 緒方 知輝, 前田 辰則, 高崎 一朗, 宮田 篤郎, 栗原 崇   PACAP誘発性疼痛反応におけるCyr61-chemokine経路に関する研究  

    日本薬学会年会要旨集  2018.3  (公社)日本薬学会

  • Kato Sho, Miyata Atsuro, Kurihara Takashi, Takasaki Ichiro   PACAPが誘導する機械的アロディニアおよび神経突起伸長に対するBtg2の関与(Involvement of Btg2 on PACAP-induced mechanical allodynia and neurite outgrowth)  

    Journal of Pharmacological Sciences  2017.3  (公社)日本薬理学会

  • 栗原 崇, 上田 隆拡, 長島 涼太, 齋藤 弘樹, 豊岡 尚樹, 合田 浩明, 宮田 篤郎, 高崎 一朗   PACAP/PAC1受容体シグナリングはオキサリプラチン誘発急性末梢神経障害疼痛発症に関与するか?  

    PAIN RESEARCH  2019.7  (一社)日本疼痛学会

  • Shibasaki Chika, Watanabe Ai, Kurihara Takashi, Miyata Atsuro, Toyooka Naoki, Takasaki Ichiro   Nitroglycerin誘発片頭痛モデルマウスにおける新規PAC1受容体アンタゴニストの効果(Effects of novel PAC1 receptor antagonist in the nitroglycerin-induced migraine model mice)  

    Journal of Pharmacological Sciences  2017.3  (公社)日本薬理学会

  • Sadamura Yuko, Kurihara Takashi, Mizunuma Ryota, Kambe Yuki, Sameshima Yoshimune, Hirasawa Akira, Nakamoto Kazuo, Oyoshi Tatsuki, Tokuyama Shogo, Arita Kazunori, Miyata Atsuro   FFAR1欠損マウスにおけるcocaine誘発自発運動の減弱(Attenuation of cocaine-induced locomotor activity in mice lacking FFAR1)  

    Journal of Pharmacological Sciences  2017.3  (公社)日本薬理学会

  • 相澤 風花, 中本 賀寿夫, 平澤 明, 栗原 崇, 宮田 篤郎, 徳山 尚吾   DHA-GPR40/FFAR1シグナルの破綻がストレス誘導性慢性疼痛を誘導する  

    日本薬学会年会要旨集  2019.3  (公社)日本薬学会

  • 栗原 崇, 宮田 篤郎, 高崎 一朗   Back to Basics科学的基盤に立脚した次世代の薬物治療を創る PACAP受容体特異的有機低分子拮抗薬のイン・シリコ創薬 難治性疼痛・そう痒治療に向けて  

    臨床薬理  2020.10  (一社)日本臨床薬理学会

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