Faculty Profiles - TAKEZAKI Toshiro

Papers - TAKEZAKI Toshiro

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Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, Ugai T, Kasugai Y, Hishida A, Takeuchi K, Okada R, Kubo Y, Shimanoe C, Tanaka K, Ikezaki H, Murata M, Takezaki T, Nishimoto D, Kuriyama N, Ozaki E, Suzuki S, Watanabe M, Mikami H, Nakamura Y, Uemura H, Katsuura-Kamano S, Kuriki K, Kita Y, Naoyuki T, Nagino M, Momozawa Y, Kubo M, Wakai K . Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study. . J Epidemiol doi: 10.2188/jea.JE20190296. 2020Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study.Reviewed

Arisawa K, Katsuura-Kamano S, Uemura H, Tien NV, Hishida A, Tamura T, Kubo Y, Tsukamoto M, Tanaka K, Hara M, Takezaki T, Nishimoto D, Koyama T, Ozaki E, Suzuki S, Nishiyama T, Kuriki K, Kadota A, Takashima N, Ikezaki H, Murata M, Oze I, Matsuo K, Mikami H, Nakamura Y, Takeuchi K, Wakai K . Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study. . Nutrients12 ( 6 ) 1605 2020Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study.Reviewed

Nishida Y, Hachiya T, Hara M, Shimanoe C, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Tsukamoto M, Kadomatsu Y, Oze I, Koyanagi YN, Kuriyama N, Koyama T, Ibusuki R, Takezaki T, Ikezaki H, Furusyo N, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Suzuki S, Nakagawa-Senda H, Kuriki K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K . The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population. . J Lipid Res doi: 10.1194/jlr.P091546 2019.11The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.Reviewed

Okada R, Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Tamura T, Hishida A, Ikezaki H, Furusyo N, Tanaka K, Hara M, Suzuki S, Watanabe M, Takezaki T, Nishimoto D, Matsui D, Watanabe I, Kuriki K, Takashima N, Nakamura Y, Katsuura-Kamano S, Arisawa K, Mikami H, Nakamura Y, Oze I, Koyanagi YN, Naito M, Wakai K . Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study. . J Hum Hypertens doi: 10.1038/s41371-019-0230-y 2019.9Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study.Reviewed

Nishiyama T. . Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population . Sleep42 ( 6 ) 2019.6

Iwasaki Y. . Associations of nutrient patterns with the prevalence of metabolic syndrome: Results from the baseline data of the Japan multi-institutional collaborative cohort study . Nutrients11 ( 5 ) 2019.5Reviewed International journal

Iwasaki Y, Arisawa K, Katsuura-Kamano S, Uemura H, Tsukamoto M, Kadomatsu Y, Okada R, Hishida A, Tanaka K, Hara M, Takezaki T, Shimatani K, Ozaki E, Koyama T, Suzuki S, Nakagawa-Senda H, Kuriki K, Miyagawa N, Kadota A, Ikezaki H, Furusyo N, Oze I, Ito H, Mikami H, Nakamura Y, Wakai K . Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study. . Nutrients11 ( 5 ) doi: 10.3390/nu11050990 2019.4Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study.Reviewed

Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin TC, Naoyuki T, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S . Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population. . Sleep doi: 10.1093/sleep/zsz046 2019.2Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population.Reviewed

Uemura H, Katsuura-Kamano S, Iwasaki Y, Arisawa K, Hishida A, Okada R, Tamura T, Kubo Y, Ito H, Oze I, Shimanoe C, Nishida Y, Nakamura Y, Takashima N, Suzuki S, Nakagawa-Senda H, Nishimoto D, Takezaki T, Mikami H, Nakamura Y, Furusyo N, Ikezaki H, Ozaki E, Koyama T, Kuriki K, Endoh K, Naito M, Wakai K . Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population. . Endocrine64 ( 3 ) 552 - 563 2019.1Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population.Reviewed

Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Sakurai-Yageta M, Nakaya N, Shimizu A, Nishizuka SS, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Takezaki T, Suzuki S, Naito M, Wakai K, Kamatani Y, Momozawa Y, Murakami Y, Inazawa J, Nakamura Y, Kubo M, Katagiri T, Miki Y . Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. . Sci Rep9 17332 2019Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population.Reviewed

Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, Hirata M, Okada R, Kawai S, Kawaguchi M, Nishida Y, Shimanoe C, Ibusuki R, Takezaki T, Nakajima M, Takao M, Ozaki E, Matsui D, Nishiyama T, Suzuki S, Takashima N, Kita Y, Endoh K, Kuriki K, Uemura H, Arisawa K, Oze I, Matsuo K, Nakamura Y, Mikami H, Tamura T, Nakashima H, Nakamura T, Kato N, Matsuda K, Murakami Y, Matsubara T, Naito M, Kubo M, Kamatani Y, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H . Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. . Commun Biol2 115 2019Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.Reviewed

Kawamura Y, Nakaoka H, Nakayama A, Okada Y, Yamamoto K, Higashino T, Sakiyama M, Shimizu T, Ooyama H, Ooyama K, Nagase M, Hidaka Y, Shirahama Y, Hosomichi K, Nishida Y, Shimoshikiryo I, Hishida A, Katsuura-Kamano S, Shimizu S, Kawaguchi M, Uemura H, Ibusuki R, Hara M, Naito M, Takao M, Nakajima M, Iwasawa S, Nakashima H, Ohnaka K, Nakamura T, Stiburkova B, Merriman TR, Nakatochi M, Ichihara S, Yokota M, Takada T, Saitoh T, Kamatani Y, Takahashi A, Arisawa K, Takezaki T, Tanaka K, Wakai K, Kubo M, Hosoya T, Ichida K, Inoue I, Shinomiya N, Matsuo H . Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. . Ann Rheum Dis78 1430 - 1437 2019Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.Reviewed

Fujii R, Hishida A, Nakatochi M, Furusyo N, Murata M, Tanaka K, Shimanoe C, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Takezaki T, Shimoshikiryo I, Arisawa K, Katsuura-Kamano S, Takashima N, Turin TC, Kuriki K, Endoh K, Mikami H, Nakamura Y, Oze I, Ito H, Kubo M, Momozawa Y, Kondo T, Naito M, Wakai K . Association of genetic risk score and chronic kidney disease in a Japanese population. . Nephrology (Carlton) doi: 10.1111/nep.13479. 2018.8Association of genetic risk score and chronic kidney disease in a Japanese population.Reviewed

Miyagawa N, Okuda N, Nakagawa H, Takezaki T, Nishi N, Takashima N, Fujiyoshi A, Ohkubo T, Kadota A, Okamura T, Ueshima H, Okayama A, Miura K . Socioeconomic Status Associated With Urinary Sodium and Potassium Excretion in Japan: NIPPON DATA2010. . J Epidemiol28 ( Supplement_III ) S29 - S34 2018.5Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：日本疫学会

BACKGROUND: Although socioeconomic status (SES) may affect food and nutrient intakes, few studies have reported on sodium (Na) and potassium (K) intakes among individuals with various SESs in Japan. We investigated associations of SES with Na and K intake levels using urinary specimens in a representative Japanese population. METHODS: This was a cross-sectional study of 2,560 men and women (the NIPPON DATA2010 cohort) who participated in the National Health and Nutrition Survey Japan in 2010. Casual urine was used to calculate estimated excretion in 24-hour urinary Na (E24hr-Na) and K (E24hr-K). The urinary sodium-to-potassium (Na/K) ratio was calculated from casual urinary electrolyte values. An analysis of covariance was performed to investigate associations of aspects of SES, including equivalent household expenditure (EHE), educational attainment, and job category, with E24hr-Na, E24hr-K, and the Na/K ratio for men and women separately. A stratified analysis was performed on educational attainment and the job category for younger (<65 years) and older (>/=65 years) participants. RESULTS: In men and women, average E24hr-Na was 176.2 mmol/day and 172.3, average E24hr-K was 42.5 and 41.3, and the average Na/K ratio was 3.61 and 3.68, respectively. Lower EHE was associated with a higher Na/K ratio in women and lower E24hr-K in men and women. A shorter education was associated with a higher Na/K ratio in women and younger men, and lower E24hr-K in older men and women. CONCLUSION: Lower EHE and a shorter education were associated with a lower K intake and higher Na/K ratio estimated from casual urine specimens in Japanese men and women.

DOI： 10.2188/jea.JE20170253

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Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Leveque K, Nagayama S, Mimori K, Mori M, Ishii H, Inazawa J, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Kubo M, Matsuda K . GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. . Carcinogenesis pii: 4868136 - pii: 4868136 2018.2GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12.

Tsuji Masayoshi, Okamura Tomonori, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, Arima Hisatomi, Ohkubo Takayoshi, Nakamura Koshi, Takezaki Toshiro, Sakata Kiyomi, Okuda Nagako, Nishi Nobuo, Kadota Aya . Socioeconomic Status and Knowledge of Cardiovascular Risk Factors: NIPPON DATA2010 . Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ28 ( 0 ) S46 - S52 2018Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：日本疫学会

Background: The relationship between socioeconomic status (SES) and knowledge of cardiovascular risk factors remains unknown in a general Japanese population.Methods: Of 8,815 participants from 300 randomly selected areas throughout Japan, 2,467 participants who were free of cardiovascular disease and who provided information on SES in the National Health and Nutrition Survey of Japan 2010 were enrolled in this cross-sectional analysis. SES was classified according to the employment status, length of education, marital and living statuses, and equivalent household expenditure (EHE). Outcomes were ignorance of each cardiovascular risk factor (hypertension, diabetes, hypercholesterolemia, low high-density lipoprotein [HDL] cholesterol, arrhythmia, and smoking) and insufficient knowledge (number of correct answers <4 out of 6).Results: A short education and low EHE were significantly associated with a greater ignorance of most cardiovascular risk factors. A short education (<10 years) was also associated with insufficient knowledge of overall cardiovascular risk factors: age- and sex-adjusted odds ratios (OR) were 1.92 (95% confidence interval [CI], 1.51–2.45) relative to participants with ≥13 years of education. Low EHE was also associated with insufficient knowledge (age- and sex-adjusted OR 1.24; 95% CI, 1.01–1.51 for the lowest quintile vs the upper 4 quintiles). These relationships remained significant, even after further adjustments for regular exercise, smoking, weekly alcohol consumption, body mass index, hypertension, diabetes mellitus, hypercholesterolemia, and low HDL cholesterol.Conclusion: Participants with a short education and low EHE were more likely to have less knowledge of cardiovascular risk factors.

DOI： 10.2188/jea.JE20170255

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PubMed

Yasuyuki Nakamura, Akira Narita, Tsuyoshi Hachiya, Yoichi Sutoh, Atsushi Shimizu, Seiko Ohno, Naoyuki Takashima, Keitaro Tanaka, Megumi Hara, Kiyoshi Kuriki, Kaori Endoh, Isao Oze, Hidemi Ito, Hirokazu Uemura, Sakurako Katsuura-Kamano, Haruo Mikami, Yohko Nakamura, Ippei Shimoshikiryo, Toshiro Takezaki, Sadao Suzuki, Miki Watanabe, Nagato Kuriyama, Teruhide Koyama, Norihiro Furusyo, Hiroaki Ikezaki, Masahiro Nakatochi, Sayo Kawai, Asahi Hishida, Rieko Okada, Takashi Tamura, Mariko Naito, Kenji Wakai, Yukihide Momozawa, Michiaki Kubo, Hirotsugu Ueshima, Yoshikuni Kita, for the J-MICC Research Group . A Genome-wide Association Study in the Diabetic Patients Finds the 13q35.43-35.46 Locus Associated with Estimated Glomerular Filtration Rate: The Japan Multi-Institutional Collaborative Cohort study. . J Clin Diabetes2 ( 2 ) 1000102 2018A Genome-wide Association Study in the Diabetic Patients Finds the 13q35.43-35.46 Locus Associated with Estimated Glomerular Filtration Rate: The Japan Multi-Institutional Collaborative Cohort study.Reviewed

Tamura T, Kadomatsu Y, Tsukamoto M, Okada R, Sasakabe T, Kawai S, Hishida A, Hara M, Tanaka K, Shimoshikiryo I, Takezaki T, Watanabe I, Matsui D, Nishiyama T, Suzuki S, Endoh K, Kuriki K, Kita Y, Katsuura-Kamano S, Arisawa K, Ikezaki H, Furusyo N, Koyanagi YN, Oze I, Nakamura Y, Mikami H, Naito M, Wakai K . Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study. . Medicine (Baltimore)97 e13241 2018Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study.Reviewed

Kanouchi H, Toyoda K, Miyazaki H, Mantjoro EM, Niimura H, Kuwabara K, Tsunematsu Nakahata N, Ibusuki R, Maenohara S, Takezaki T . Relationship between Dietary Habits and Plasma Homocysteine Concentrations in Elderly Japanese Women and Men. . Food and Nutrition Sciences9 595 - 608 2018Relationship between Dietary Habits and Plasma Homocysteine Concentrations in Elderly Japanese Women and Men.Reviewed

Kairupan TS, Ibusuki R, Kheradmand M, Sagara Y, Mantjoro EM, Nindita Y, Niimura H, Kuwabara K, Ogawa S, Tsumematsu-Nakahata N, Nerome Y, Owaki T, Matsushita T, Maenohara S, Yamaguchi K, Takezaki T . Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population. . J Epidemiol27 ( 9 ) 420 - 427 2017.9Invited Reviewed

Language：English Publishing type：Research paper (scientific journal) Publisher：日本疫学会

BACKGROUND: An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases. METHOD: We selected 2180 sub-cohort subjects aged 35-69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-alpha, IL-10, and NF-kappaB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases. RESULTS: HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-alpha 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-kappaB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18-7.77). CONCLUSION: The present study found the interaction between TNF-alpha 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.

DOI： 10.1016/j.je.2016.08.017

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PubMed

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Papers - TAKEZAKI Toshiro