Faculty Profiles - TAKEZAKI Toshiro

Papers - TAKEZAKI Toshiro

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Hanyuda A., Goto A., Katagiri R., Koyanagi Y.N., Nakatochi M., Sutoh Y., Nakano S., Oze I., Ito H., Yamaji T., Sawada N., Iwagami M., Kadota A., Koyama T., Katsuura-Kamano S., Ikezaki H., Tanaka K., Takezaki T., Imoto I., Suzuki M., Momozawa Y., Takeuchi K., Narita A., Hozawa A., Kinoshita K., Shimizu A., Tanno K., Matsuo K., Tsugane S., Wakai K., Sasaki M., Yamamoto M., Iwasaki M. . Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation . Scientific Reports13 ( 1 ) 7052 2023.12

Language：Japanese Publisher：Scientific Reports

Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed to determine the causal association between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), and fasting C-peptide and colorectal cancer risk. In the single nucleotide polymorphism (SNP)-exposure analysis, we meta-analysed study-level genome-wide associations of fasting glucose (~ 17,289 individuals), HbA1c (~ 52,802 individuals), and fasting C-peptide (1,666 individuals) levels from the Japanese Consortium of Genetic Epidemiology studies. The odds ratios of colorectal cancer were 1.01 (95% confidence interval [CI], 0.99–1.04, P = 0.34) for fasting glucose (per 1 mg/dL increment), 1.02 (95% CI, 0.60–1.73, P = 0.95) for HbA1c (per 1% increment), and 1.47 (95% CI, 0.97–2.24, P = 0.06) for fasting C-peptide (per 1 log increment). Sensitivity analyses, including Mendelian randomisation-Egger and weighted-median approaches, revealed no significant association between glycaemic characteristics and colorectal cancer (P > 0.20). In this study, genetically predicted glycaemic characteristics were not significantly related to colorectal cancer risk. The potential association between insulin resistance and colorectal cancer should be validated in further studies.

DOI： 10.1038/s41598-023-33966-7

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Hara Megumi, Nishida Yuichiro, Tanaka Keitaro, Shimanoe Chisato, Koga Kayoko, Furukawa Takuma, Higaki Yasuki, Shinchi Koichi, Ikezaki Hiroaki, Murata Masayuki, Takeuchi Kenji, Tamura Takashi, Hishida Asahi, Tsukamoto Mineko, Kadomatsu Yuka, Matsuo Keitaro, Oze Isao, Mikami Haruo, Kusakabe Miho, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Nakagawa-Senda Hiroko, Matsui Daisuke, Koyama Teruhide, Kuriki Kiyonori, Takashima Naoyuki, Nakamura Yasuyuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Wakai Kenji . 中高強度の身体活動と座位行動は独立して腎機能と関連する　横断研究(Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study) . Journal of Epidemiology33 ( 5-6 ) 285 - 293 2023.6中高強度の身体活動と座位行動は独立して腎機能と関連する　横断研究(Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study)

Nindita Yora, Nakatochi Masahiro, Ibusuki Rie, Shimoshikiryo Ippei, Nishimoto Daisaku, Shimatani Keiichi, Takezaki Toshiro, Ikezaki Hiroaki, Murata Masayuki, Hara Megumi, Nishida Yuichiro, Tamura Takashi, Hishida Asahi, Nagayoshi Mako, Okada Rieko, Matsuo Keitaro, Ito Hidemi, Mikami Haruo, Nakamura Yohko, Otani Takahiro, Suzuki Sadao, Koyama Teruhide, Ozaki Etsuko, Kuriki Kiyonori, Takashima Naoyuki, Miyagawa Naoko, Arisawa Kokichi, Katsuura-Kamano Sakurako, Momozawa Yukihide, Kubo Michiaki, Takeuchi Kenji, Wakai Kenji, the Japan Multi-Institutional Collaborative Cohort Study Group . HDLコレステロール値に対する喫煙、飲酒、遺伝要因のJ-MICC研究参加者における集団ベースの影響(Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants) . Journal of Epidemiology33 ( 3-4 ) 193 - 200 2023.4HDLコレステロール値に対する喫煙、飲酒、遺伝要因のJ-MICC研究参加者における集団ベースの影響(Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants)

Language：English Publisher：(一社)日本疫学会

＜Highlight＞●飲酒、日常活動、習慣的運動、卵摂取および女性はHDLコレステロール値と正の関連、喫煙、BMIおよび年齢は負の関連を示した。●GWASにおいて、7 SNP(CETP、APOA5、LIPC、LPL、ABCA1、LIPG、APOE)がHDLコレステロール値と関連していた。●非遺伝要因における、低HDLコレステロールに対するPAFは男性が最も高かった。●遺伝要因における、低HDL-Cに対するPAFはCETP rs3764261が最も高かった。●低HDLコレステロールに対する遺伝要因であるCETP rs3764261のPAFは、喫煙よりも高く、飲酒よりも低く、非遺伝要因と同程度のインパクトを有していることが示された。(著者抄録)

嶽﨑俊郎、東桂子、古田真美、太鼓真規、大脇哲洋、網谷真理恵、指宿りえ、水間喜美子 . 鹿児島県における42年間の全死亡、悪性新生物、脳卒中の標準化死亡比の地域比較と経年変化 . 九州農医30・31 32 - 39 2023.3鹿児島県における42年間の全死亡、悪性新生物、脳卒中の標準化死亡比の地域比較と経年変化Invited

Nakamura S., Fang X., Saito Y., Narimatsu H., Ota A., Ikezaki H., Shimanoe C., Tanaka K., Kubo Y., Tsukamoto M., Tamura T., Hishida A., Oze I., Koyanagi Y.N., Nakamura Y., Kusakabe M., Takezaki T., Nishimoto D., Suzuki S., Otani T., Kuriyama N., Matsui D., Kuriki K., Kadota A., Nakamura Y., Arisawa K., Katsuura-Kamano S., Nakatochi M., Momozawa Y., Kubo M., Takeuchi K., Wakai K. . Effects of gene–lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis . PLoS ONE18 ( 2 February ) e0279169 2023.2

Language：Japanese Publisher：PLoS ONE

Background The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene–environment interactions, has been attracting attention in recent years. However, evidence for gene–environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene–lifestyle interactions in practice could aid in optimizing interventions according to genetic risk. Methods This study aimed to elucidate the effects of gene–lifestyle interactions on body mass index (BMI). Cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study were used. Interactions between a multi-locus genetic risk score (GRS), calculated from 76 ancestry-specific single nucleotide polymorphisms, and nutritional intake or physical activity were assessed using a linear mixed-effect model. Results The mean (standard deviation) BMI and GRS for all participants (n = 12,918) were 22.9 (3.0) kg/m2 and -0.07 (0.16), respectively. The correlation between GRS and BMI was r (12,916) = 0.13 (95% confidence interval [CI] 0.11–0.15, P < 0.001). An interaction between GRS and saturated fatty acid intake was observed (β = -0.11, 95% CI -0.21 to -0.02). An interaction between GRS and n-3 polyunsaturated fatty acids was also observed in the females with normal-weight subgroup (β = -0.12, 95% CI -0.22 to -0.03). Conclusion Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene–lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition.

DOI： 10.1371/journal.pone.0279169

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Saito Yoshinobu, Oguma Yuko, Nakamura Sho, Narimatsu Hiroto, Nakashima Ryoko, Ikezaki Hiroaki, Tanaka Keitaro, Hara Megumi, Tamada Yudai, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Oze Isao, Taniyama Yukari, Mikami Haruo, Nagase Hiroki, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Otani Takahiro, Koyama Teruhide, Watanabe Isao, Kuriki Kiyonori, Kita Yoshikuni, Takashima Naoyuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Takeuchi Kenji, Wakai Kenji, J-MICC Study Group . Questionnaire-assessed physical activity among Japanese adults: The J-MICC Study . Research in Exercise Epidemiologyadvpub ( 0 ) 2023Questionnaire-assessed physical activity among Japanese adults: The J-MICC Study

Nishimoto Daisaku, Kodama Shimpei, Shimoshikiryo Ippei, Ibusuki Rie, Nerome Yasuhito, Takezaki Toshiro, Nishio Ikuko . Association Between Nursing Discussions, Resilience, Workplace Social Support and Burnout: A Quantitative Study in Japan . Yonago Acta Medica66 ( 3 ) 355 - 364 2023Association Between Nursing Discussions, Resilience, Workplace Social Support and Burnout: A Quantitative Study in Japan

Language：English Publisher：Tottori University Medical Press

Background Although it is known that resilience is negatively associated with burnout, and that certain interventions can effectively increase resilience, little is known about online resilience-enhancing interventions during the COVID-19 crisis. The aim of this study was to identify the association between an online resilience-enhancing intervention and workplace social support, and burnout among nurses working in the mainland and remote islands of Japan during the COVID-19 crisis.Methods Pretest-posttest was conducted between April 2020 and February 2021, and the questionnaire survey included the bidimensional resilience scale, the Japanese version of Pine’s Burnout Measure, and the workplace social support scale. Changes in burnout, resilience, and social support and the associations with nursing discussions as intervention were analyzed. Participants were 98 Nurses with 1 to 10 years of experience from Japan’s mainland and remote island hospitals of Kagoshima Prefecture participated in a baseline survey in April 2020. Of these, 76 participated in a secondary survey in September 2020, and 69 participated in the intervention program and a third survey in February 2021. The online intervention over Zoom consisted of small-group nursing discussions based on the broaden-and-build theory.Results Changes in burnout showed a significant negative association with change in workplace social support (Coef. = –0.019, 95% CI –0.035– –0.003), as did the interaction between change in acquired resilience and intervention (Coef. = –0.088, 95% CI –0.164– –0.011).Conclusion Change in workplace social support was significantly negatively associated with changes in burnout, as was the interaction of intervention and acquired resilience. Promotion of this intervention and making workplace social support more accessible may contribute to reduce burnout in nurses.

DOI： 10.33160/yam.2023.08.008

PubMed

Fujii Ryosuke, Hishida Asahi, Nishiyama Takeshi, Nakatochi Masahiro, Matsuo Keitaro, Ito Hidemi, Nishida Yuichiro, Shimanoe Chisato, Nakamura Yasuyuki, Turin Tanvir Chowdhury, Suzuki Sadao, Watanabe Miki, Ibusuki Rie, Takezaki Toshiro, Mikami Haruo, Nakamura Yohko, Ikezaki Hiroaki, Murata Masayuki, Kuriki Kiyonori, Kuriyama Nagato, Matsui Daisuke, Arisawa Kokichi, Katsuura-Kamano Sakurako, Tsukamoto Mineko, Tamura Takashi, Kubo Yoko, Kondo Takaaki, Momozawa Yukihide, Kubo Michiaki, Takeuchi Kenji, Wakai Kenji . 地域住民を対象としたJ-MICC Studyにおける高感度CRPと腎機能との関係に関するメンデルランダム化解析による評価(Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study) . Journal of Epidemiology32 ( 11-12 ) 483 - 488 2022.12地域住民を対象としたJ-MICC Studyにおける高感度CRPと腎機能との関係に関するメンデルランダム化解析による評価(Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study)

Language：English Publisher：(一社)日本疫学会

<Highlight>●本研究では、10,542名の日本人集団を対象にメンデルランダム化解析の手法を用いて、高感度CRP(hs-CRP)と推定糸球体濾過量(eGFR)の因果関係を推定した。●我々は、欧米人集団およびアジア人集団で同定されたSNPに基づいた異なる2つの操作変数(IVCRPとIVAsian)を使用した。●2つの操作変数(IVCRPとIVAsian)によるhs-CRPの説明率は、それぞれ3.4%と3.9%であった。●従来の線形回帰分析の結果、血清hs-CRP濃度とeGFRとの有意な関連を認めた。●2つの操作変数(IVCRPとIVAsian)を使用したtwo-sample MRを行なった結果、血清hs-CRPとeGFRとの因果関係を支持するものではなかった。(著者抄録)

Saita K., Sumitani M., Nishizawa D., Tamura T., Ikeda K., Wakai K., Sudo Y., Abe H., Otonari J., Ikezaki H., Takeuchi K., Hishida A., Tanaka K., Shimanoe C., Takezaki T., Ibusuki R., Oze I., Ito H., Ozaki E., Matsui D., Nakamura Y., Kusakabe M., Suzuki S., Nakagawa-Senda H., Arisawa K., Katsuura-Kamano S., Kuriki K., Kita Y., Nakamura Y., Momozawa Y., Uchida K. . Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study . Medicine (United States)101 ( 37 ) e30580 2022.9

Language：Japanese Publisher：Medicine (United States)

Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598) - located on the gene encoding for pleiotrophin on chromosome 7 - that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (P = 1.31 × 10-7, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (P =.028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing.

DOI： 10.1097/MD.0000000000030580

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Nishimoto Daisaku, Imajo Mine, Kodama Shimpei, Shimoshikiryo Ippei, Ibusuki Rie, Nerome Yasuhito, Takezaki Toshiro, Nishio Ikuko . 鹿児島県内の臨床看護師のバーンアウトに対するレジリエンスと関連要因の影響(The Effects of Resilience and Related Factors on Burnout in Clinical Nurses, Kagoshima, Japan) . Yonago Acta Medica65 ( 2 ) 148 - 159 2022.5鹿児島県内の臨床看護師のバーンアウトに対するレジリエンスと関連要因の影響(The Effects of Resilience and Related Factors on Burnout in Clinical Nurses, Kagoshima, Japan)

Language：English Publisher：ヨナゴ・アクタ・メディカ刊行会

鹿児島県内の2施設で働く臨床看護師を対象に、バーンアウトに対してレジリエンスと関連要因が及ぼす影響を横断的に調査した。本質問紙調査にはPinesのバーンアウト尺度や二次元レジリエンス要因尺度などを使用し、2020年4月に実施した。2施設のうち一方は本土の都市部にある500床を超える三次医療機関で、看護師82名(本土群)に質問紙を配布した。もう一方は離島にある中核病院であり、看護師70名(離島群)に配布した。合わせて99名(65%)から回答が得られ、不適格の1名を除く本土群59名(女性51名、性別記載なし1名)と離島群39名(女性28名)の回答内容を解析した。バーンアウトの有症率は本土群で20%、離島群で36%であった。生得的レジリエンスという要因はバーンアウトと負に関連していることがどちらの群でも示された。また獲得的レジリエンスにも同様の関連性が観察された(本土群でP=0.007、離島群でP=0.057)。全集団においては、生得的レジリエンスと職場での社会的支援がバーンアウトと負に関連し、離職意図は正に関連していることが示された。

Ohashi Mizuki, Miura Katsuyuki, Takashima Naoyuki, Kadota Aya, Saito Yoshino, Tsuji Shunichiro, Murakami Takashi, Kadomatsu Yuka, Nagayoshi Mako, Hara Megumi, Tanaka Keitaro, Tamura Takashi, Hishida Asahi, Takezaki Toshiro, Shimoshikiryo Ippei, Ozaki Etsuko, Watanabe Isao, Suzuki Sadao, Watanabe Miki, Kuriki Kiyonori, Arisawa Kokichi, Katsuura-Kamano Sakurako, Yamasaki Sho, Ikezaki Hiroaki, Oze Isao, Koyanagi Yuriko N., Mikami Haruo, Nakamura Yohko, Takeuchi Kenji, Kita Yoshikuni, Wakai Kenji, the Japan Multi-institutional Collaborative Cohort(J-MICC) Study Group . 閉経状態別にみた妊娠歴と高血圧および肥満との関連　J-MICC研究(The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study) . Hypertension Research45 ( 4 ) 708 - 714 2022.4閉経状態別にみた妊娠歴と高血圧および肥満との関連　J-MICC研究(The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study)

Language：English Publisher：Nature Publishing Group

J-MICC研究から得たデータを用いて、妊娠歴と高血圧および肥満との関連について検討した。J-MICC研究のベースライン調査では各種身体データ、血液サンプル、自記式問診票データが収集された。8地域の女性24558名を解析対象とした。ロジスティック回帰分析の結果、閉経前女性において出産は高血圧に対して全般的に予防効果を示した。しかし、肥満に対する影響は認められなかった。閉経後女性において、出産は肥満および高血圧と正の相関を示したが、BMI調整後、高血圧との相関は認められなくなった。以上から、妊娠歴は高血圧および肥満と関連しているが、この関連は閉経前女性と閉経後女性で異なっていることが示された。

Amitani M, Amitani H, Suzuki H, Kawazu S, Mizuma K, Yamaguchi K, Oki T, Nitta H, Sonoda T, Kawano K, Tanaka Y, Uto N, Ibusuki R, Arita R, Takayama S, Mitsuma T, Takezaki T, Asakawa A, Owaki T . Application of objective structured clinical examination (OSCE) for the evaluation of Kampo medicine training. . BMC medical education22 ( 1 ) 202 2022.3Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Medical Education

Background: The purpose of this study was to develop an objective, content-valid, and reliable assessment method for Kampo medicine using an objective structured clinical examination (OSCE) for the assessment of clinical competence in Kampo medicine. Methods: We developed a blueprint followed by a list of 47 assessment items and three task scenarios related to clinical competence in Kampo medicine. An eight-member test committee checked the relevance of the assessment items on a Likert scale. We calculated a content validity index and content validity ratio, and used the Angoff method to set the passing threshold. We trained a total of nine simulated patients with three assigned to each scenario. We conducted an OSCE for 11 candidates with varying medical abilities, and conducted three stations per person, which were evaluated by one evaluator in one room by direct observation. We used video recordings to test the inter-rater reliability of the three raters. We used the test results to verify the reliability of the assessment chart. Results: The inter-rater reliability (intraclass correlation coefficient [2,1]) was 0.973. The reliability of the assessment chart for each scenario (Cronbach’s α) was 0.86, 0.89, and 0.85 for Scenarios 1, 2, and 3, respectively. The reliability of the assessment chart for the whole OSCE (Cronbach’s α) was 0.90. Conclusions: We developed a content-valid new OSCE assessment method for Kampo medicine and obtained high inter-rater and test reliabilities. Our findings suggest that this is one of the most reliable evaluation methods for assessing clinical competence in Kampo medicine.

DOI： 10.1186/s12909-022-03264-3

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Matsunaga T. . Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study . PLoS ONE17 ( 1 January ) e0262252 2022.1Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：PLoS ONE

Objective The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. Methods The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Results Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose–response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ?4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ?55 years old. Conclusions Breastfeeding history may be related to lower prevalence of metabolic syndrome in middleaged parous women.

DOI： 10.1371/journal.pone.0262252

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Ohashi M. . The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study . Hypertension Research45 ( 4 ) 708 - 714 2022Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：Hypertension Research

Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status. We evaluated the association of reproductive history with hypertension and obesity using a large cross-sectional dataset from the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). At the baseline survey, physical data, blood samples, and self-reported health questionnaires were collected. Participants with insufficient data were excluded, and 24,558 women from eight study regions were included in this study. Logistic regression analysis was conducted to evaluate the association of reproductive history with hypertension and obesity using multivariable-adjusted odds ratios. In premenopausal women, childbirth showed a generally protective effect on hypertension but not on obesity. In postmenopausal women, childbirth was positively associated with obesity and hypertension but not with hypertension after adjusting for BMI. In conclusion, reproductive history was associated with hypertension and obesity in a large Japanese population, and this association differed between premenopausal and postmenopausal women.

DOI： 10.1038/s41440-021-00820-0

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Nishimoto Daisaku, Imajo Mine, Kodama Shimpei, Shimoshikiryo Ippei, Ibusuki Rie, Nerome Yasuhito, Takezaki Toshiro, Nishio Ikuko . The Effects of Resilience and Related Factors on Burnout in Clinical Nurses, Kagoshima, Japan . Yonago Acta Medica65 ( 2 ) 148 - 159 2022

Language：English Publisher：Tottori University Medical Press

Background Burnout, due to extreme mental and physical fatigue, and emotional exhaustion, leads to decreased nursing quality and turnover. However, not all nurses are observed as burnouts in the same work environment, and resilience and related factors may have effects on the development of burnouts. Therefore, we conducted a cross-sectional study to examine the effects of resilience and related factors on the burnout in clinical nurses, Kagoshima, Japan.Methods Data for this cross-sectional study involving nurses (n = 98) was collected using the following questionnaire surveys: the Bidimensional Resilience Scale, The Workplace Social Support Scale, and the Japanese version of the Pine’s Burnout Scale. Using burnout as a dependent variable, analyses were conducted using one-way analysis of variance and multiple regression analysis after adjusted for related factors.Results The prevalence of burnouts was 19.6% on the mainland and 36.1% on remote island. Innate resilience, acquired resilience, workplace social support, and burnout showed no significant difference between nurses on the mainland and remote island. In the mainland participants, innate resilience (β = –0.492, P < 0.001) and acquired resilience (β = –0.325, P = 0.007) showed a negative association with burnout, and similar associations were observed innate resilience (β = –0.520, P = 0.004) and acquired resilience (β = –0.336, P = 0.057) in the remote island participants. For all participants, innate resilience (β = –0.443, P = 0.001) and workplace social support (β = –0.204, P = 0.031) showed a negative association with burnout, and turnover intention was positively associated (β = 0.025, P = 0.021).Conclusion A negative association between burnout and innate resilience factors was observed in the mainland and remote island. Further evaluation of innate resilience is necessary for burnout prevention in clinical nurses.

DOI： 10.33160/yam.2022.05.007

PubMed

Yasuda T., Miyamoto K., Akaho T., Ibusuki R., Shimoshikiryo I., Nishimoto D., Takezaki T. . Intake of local vegetables and decreased risk of mortality and cancer incidence in Amami island regions, Japan . Asia Pacific journal of clinical nutrition31 ( 4 ) 780 - 789 2022

Language：Japanese Publisher：Asia Pacific journal of clinical nutrition

BACKGROUND AND OBJECTIVES: There is emerging scientific evidence of the health benefits of traditional food plants at both molecular and folk remedy levels; however, epidemiological observations are limited. The Amami island region of Japan has a variety of unique traditions conserved till today, where a cohort study was conducted in 2005. The objective of this study was to investigate the associations between the intake of common and local vegetables and the risk of mortality and cancer incidence in Amami. METHODS AND STUDY DESIGN: Participants were enrolled from the general population of Amami as part of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. In total, 5,015 participants (2,053 men and 2,962 women) aged 35-69 years were enrolled in this study. They were followed up to obtain information on movement, death, and cancer incidence. The hazard ratios (HRs) and 95% CIs were estimated using the Cox proportional hazard model after adjusting for potential confounding factors. RESULTS: A significant inverse association was observed between cabbage intake and the HRs for overall mortality (p for trend=0.046) and lung cancer incidence (p=0.016). Intake of handama and togan as local vegetables was associated with decreased HRs for overall mortality (p=0.019 and 0.036, respectively). CONCLUSIONS: While the molecular and biochemical reasoning and residual confounding factors behind this association remain unclear, the findings of this study suggest that the dietary lifestyle in Amami has a positive impact on the residents, which can significantly decrease mortality risk.

DOI： 10.6133/apjcn.202212_31(4).0020

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Katsuura-Kamano S. . Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population: Baseline data from the Japan Multi-Institutional Collaborative cohort study . Preventive Medicine Reports24 101613 2021.12Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：Preventive Medicine Reports

The purpose of the study was to investigate sex-specific associations of skipping breakfast and short sleep duration with metabolic syndrome (MetS) and their interaction. We analyzed baseline data of 14,907 men and 14,873 women aged 35–69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study from 2005. MetS was diagnosed using a modification of the National Cholesterol Education Program Adult Treatment Panel III revised definition (NCEP-R 2005), using body mass index instead of waist circumference. Breakfast consumption was classified into two categories: ≥6 days/week (consumers) or <6 days/week (skippers). Sleep duration was classified into three categories: <6h, 6 to <8 h, and ≥8 h/day. Multivariate logistic regression analysis was performed to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) and examine the presence of interaction. In men, skipping breakfast and short sleep duration were independently associated with an increased prevalence of MetS (OR 1.26, 95%CI 1.12–1.42 and OR 1.28, 95%CI 1.12–1.45, respectively), obesity, and components of MetS. However, no significant interaction was observed between skipping breakfast and short sleep duration. In women, skipping breakfast and short sleep duration were associated with an increased prevalence of obesity, but not with MetS. These findings indicate that breakfast consumption and moderate sleep duration may be associated with a lower risk of MetS, particularly in men.

DOI： 10.1016/j.pmedr.2021.101613

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Takeuchi Kenji, Naito Mariko, Kawai Sayo, Tsukamoto Mineko, Kadomatsu Yuka, Kubo Yoko, Okada Rieko, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Nakatochi Masahiro, Sasakabe Tae, Hashimoto Shuji, Eguchi Hidetaka, Momozawa Yukihide, Ikezaki Hiroaki, Murata Masayuki, Furusyo Norihiro, Tanaka Keitaro, Hara Megumi, Nishida Yuichiro, Matsuo Keitaro, Ito Hidemi, Oze Isao, Mikami Haruo, Nakamura Yohko, Kusakabe Miho, Takezaki Toshiro, Ibusuki Rie, Shimoshikiryo Ippei, Suzuki Sadao, Nishiyama Takeshi, Watanabe Miki, Koyama Teruhide, Ozaki Etsuko, Watanabe Isao, Kuriki Kiyonori, Kita Yoshikuni, Ueshima Hirotsugu, Matsui Kenji, Arisawa Kokichi, Uemura Hirokazu, Katsuura-Kamano Sakurako, Nakamura Sho, Narimatsu Hiroto, Hamajima Nobuyuki, Tanaka Hideo, Wakai Kenji . Study Profile of the Japan Multi-institutional Collaborative Cohort(J-MICC) Study(和訳中) . Journal of Epidemiology31 ( 11-12 ) 660 - 668 2021.12Study Profile of the Japan Multi-institutional Collaborative Cohort(J-MICC) Study(和訳中)Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：(一社)日本疫学会

2005年に開始された、癌を含む生活習慣病の遺伝子-環境相互作用を調べるための日本多施設共同コホート(J-MICC)研究について、研究デザインならびに参加者のベースラインプロファイルについて報告した。2005年～2014年にかけ行われたベースライン調査では、12府県14の調査地域に居住する住民92610名(男性40880名、女性51730名、年齢35歳～69歳)を対象に、属性や学歴、飲酒、喫煙、睡眠、運動、食物摂取頻度、服薬やサプリメントの使用、本人および家族の既往歴や精神的ストレスおよび妊娠歴に関するアンケート調査と、末梢血試料を生体試料として採取した。なお、本調査への参加率の平均33.5%で、最も参加が得られた年齢層は男性が65歳～69歳、女性が60歳～64歳であり、男女間でBMIや学歴、飲酒、喫煙および睡眠時間に差が認められたものの、本研究により、9万人以上の参加者から、ライフスタイルに関する臨床データや生体試料が収集された。また、大規模集団による本コホート研究は、健康寿命を支援するエビデンス提供の面でも、国内外科学コミュニティの貴重な資源となり得ることが期待された。

Nakamura Y. . A genome-wide association study on meat consumption in a Japanese population: The Japan Multi-Institutional Collaborative Cohort study . Journal of Nutritional Science10 e61 2021.10Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Nutritional Science

Recent genome-wide association studies (GWAS) on the dietary habits of the Japanese population have shown that an effect rs671 allele was inversely associated with fish consumption, whereas it was directly associated with coffee consumption. Although meat is a major source of protein and fat in the diet, whether genetic factors that influence meat-eating habits in healthy populations are unknown. This study aimed to conduct a GWAS to find genetic variations that affect meat consumption in a Japanese population. We analysed GWAS data using 14 076 participants from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. We used a semi-quantitative food frequency questionnaire to estimate food intake that was validated previously. Association of the imputed variants with total meat consumption per 1000 kcal energy was performed by linear regression analysis with adjustments for age, sex, and principal component analysis components 1-10. We found that no genetic variant, including rs671, was associated with meat consumption. The previously reported single nucleotide polymorphisms that were associated with meat consumption in samples of European ancestry could not be replicated in our J-MICC data. In conclusion, significant genetic factors that affect meat consumption were not observed in a Japanese population.

DOI： 10.1017/jns.2021.49

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Kawamura Y. . A proposal for practical diagnosis of renal hypouricemia: Evidenced from genetic studies of nonfunctional variants of urat1/slc22a12 among 30,685 japanese individuals . Biomedicines9 ( 8 ) 2021.8Reviewed International journal

Language：English Publishing type：Research paper (scientific journal) Publisher：Biomedicines

Background: Renal hypouricemia (RHUC) is characterized by a low serum uric acid (SUA) level and high fractional excretion of uric acid (FEUA). Further studies on FEUA in hypouricemic individuals are needed for a more accurate diagnosis of RHUC. Methods: In 30,685 Japanese health-examination participants, we genotyped the two most common nonfunctional variants of URAT1 (NFV-URAT1), W258X (rs121907892) and R90H (rs121907896), in 1040 hypouricemic individuals (SUA ≤ 3.0 mg/dL) and 2240 individuals with FEUA data. The effects of NFV-URAT1 on FEUA and SUA were also investigated using linear and multiple regression analyses. Results: Frequency of hypouricemic individuals (SUA ≤ 3.0 mg/dL) was 0.97% (male) and 6.94% (female) among 30,685 participants. High frequencies of those having at least one allele of NFV-URAT1 were ob-served in 1040 hypouricemic individuals. Furthermore, NFV-URAT1 significantly increased FEUA and decreased SUA, enabling FEUA and SUA levels to be estimated. Conversely, FEUA and SUA data of hypouricemic individuals are revealed to be useful to predict the number of NFV-URAT1. Conclusions: Our findings reveal that specific patterns of FEUA and SUA data assist with predicting the number of nonfunctional variants of causative genes for RHUC, and can also be useful for practical diagnosis of RHUC even before genetic tests.

DOI： 10.3390/biomedicines9081012

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