Faculty Profiles - SANO Akira

Papers - SANO Akira

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Suzuki F, Sato N, Ota M, Sugiyama A, Shigemoto Y, Morimoto E, Kimura Y, Wakasugi N, Takahashi Y, Futamura A, Kawamura M, Ono K, Nakamura M, Sano A, Watanabe M, Matsuda H, Abe O . Discriminating chorea-acanthocytosis from Huntington's disease with single- case voxel-based morphometry analysis . J Neurol Sci408 116545 2019.10Reviewed

佐野　輝 . 【現代医学・生物学の先駆者たち】神経科学　佐野勇(1924-1975)　精神神経医学に神経化学の光を当てた医学者 . 生体の科学70 ( 5 ) 458 - 459 2019.10Invited

Kawaike Y, Nagata J, Furuya T, Koriyama C, Nakamura M, Sano A . Working memory-related prefrontal hemodynamic responses in university students: A correlation study of subjective well-being and lifestyle habits. . Front Behav Neurosci 2019.9Reviewed

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Identification of social risk factors and the promotion of stress coping mechanisms and mental resilience are topics of interest in the field of mental health. The relationships between risk- or tolerability-associated factors and task-related hemodynamic responses in the prefrontal cortex (PFC) in adolescents may have important implications for mental health challenges. The purpose of this study was to investigate the relationship between task-related PFC hemodynamic activities and subjective well-being or lifestyle habits using wearable near-infrared spectroscopy (NIRS). In this study, after sample refinement to reduce heterogeneity, 20 university students were included in verbal working memory (VWM) task analyses and 21 were included in spatial working memory (SWM) task analyses. The task-related hemodynamic responses were detected using wearable NIRS. To assess the risk- or tolerability-associated factors, the levels of positive and negative affect were assessed using the Subjective Well-Being Inventory (SUBI) and lifestyle habits (such as gaming) were evaluated using a nine-item questionnaire. There was a positive correlation between SUBI positive affect and VWM task-related oxy-hemoglobin signal changes in the right dorsolateral PFC (DLPFC), underlining the significance of subjective well-being as an important independent emotional domain and suggesting the possibility of the differential objective evaluations of subjective well-being in the right PFC. Negative correlations between PFC activities during both VWM and SWM tasks at the left DLPFC and the number of game playing days in 1 week were also statistically significant, suggesting the presence of modality-non-specific hemodynamic regulation by habitual game playing. Each correlation was still robust after the elimination of major confounding impacts. Although further replication studies are warranted to confirm these preliminary results, this investigation of the relationship between task-related PFC hemodynamic activities and emotional domains or lifestyle habits might have clinical significance with regard to primary prevention of mental health issues in university students. To our knowledge, this is the first demonstration of these relationships with the use of wearable NIRS, which enables measurement under near natural conditions and is easy to use in schools or workplaces.

Keywords: wearable near-infrared spectroscopy, working memory, subjective well-being, lifestyle, university students, mental health

DOI： 10.3389/fnbeh.2019.00213

PubMed

中村雅之, 佐野輝 . 【指定難病ペディア2019】個別の指定難病　神経・筋系　神経有棘赤血球症[指定難病9] . 日本医師会雑誌148 ( 特別1 ) S114 2019.6

Nishida Y, Nakamura M, Urata Y, Kasamo K, Hiwatashi H, Yokoyama I, Mizobuchi M, Sakurai K, Osaki Y, Morita Y, Watanabe M, Yoshida K, Yamane K, Miyakoshi N, Okiyama R, Ueda T, Wakasugi N, Saitoh Y, Sakamoto T, Takahashi Y, Shibano K, Tokuoka H, Hara A, Monma K, Ogata K, Kakuda K, Mochizuki H, Arai T, Araki M, Fujii T, Tsukita K, Sakamaki-Tsukita H, MD, and Sano A . Novel pathogenic VPS13A gene mutations in Japanese patients with chorea-acanthocytosis. . Neurol Genet5 e332 2019.5Reviewed

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE:
To identify mutations in vacuolar protein sorting 13A (VPS13A) for Japanese patients with suspected chorea-acanthocytosis (ChAc).
METHODS:
We performed a comprehensive mutation screen, including sequencing and copy number variation (CNV) analysis of the VPS13A gene, and chorein Western blotting of erythrocyte ghosts. As the results of the analysis, 17 patients were molecularly diagnosed with ChAc. In addition, we investigated the distribution of VPS13A gene mutations and clinical symptoms in a total of 39 molecularly diagnosed Japanese patients with ChAc, including 22 previously reported cases.
RESULTS:
We identified 11 novel pathogenic mutations, including 1 novel CNV. Excluding 5 patients with the unknown symptoms, 97.1% of patients displayed various neuropsychiatric symptoms or forms of cognitive dysfunction during the course of disease. The patients carrying the 2 major mutations representing over half of the mutations, exon 60-61 deletion and exon 37 c.4411C>T (R1471X), were localized in western Japan.
CONCLUSIONS:
We identified 13 different mutations in VPS13A, including 11 novel mutations, and verified the clinical manifestations in 39 Japanese patients with ChAc.

DOI： 10.1212/NXG.0000000000000332

PubMed

中村雅之, 佐野輝 . 【プライマリーケアに役立つ　うつ・不安・不眠の診療】不安　抗不安薬の種類と使い方 . 臨牀と研究96 ( 5 ) 539 - 544 2019.5Invited

Yuka Urata, Masayuki Nakamura, Natsuki Sasaki, Nari Shiokawa, Yoshiaki Nishida, Kaoru Arai, Hanae Hiwatashi, Izumi Yokoyama, Shinsuke Narumi, Yasuo Terayama, Takenobu Murakami, Yoshikazu Ugawa, Hiroki Sakamoto, Satoshi Kaneko, Yusuke Nakazawa, Ryo Yamasaki, Shoko Sadashima, Toshiaki Sakai, Hiroaki Arai, Akira Sano . Novel pathogenic XK mutations in McLeod syndrome and interaction between XK protein and chorein . Neurol Genet5 e328 2019.4Reviewed

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Objective To identify XK pathologic mutations in 6 patients with suspected McLeod syndrome (MLS) and a possible interaction between the chorea-acanthocytosis (ChAc)- and MLS-responsible proteins: chorein and XK protein.

Methods Erythrocyte membrane proteins from patients with suspected MLS and patients with ChAc, ChAc mutant carriers, and normal controls were analyzed by XK and chorein immunoblotting. We performed mutation analysis and XK immunoblotting to molecularly diagnose the patients with suspected MLS. Lysates of cultured cells were co-immunoprecipitated with anti-XK and anti-chorein antibodies.

Results All suspected MLS cases were molecularly diagnosed with MLS, and novel mutations were identified. The average onset age was 46.8 ± 8 years, which was older than that of the patients with ChAc. The immunoblot analysis revealed remarkably reduced chorein immunoreactivity in all patients with MLS. The immunoprecipitation analysis indicated a direct or indirect chorein-XK interaction.

Conclusions In this study, XK pathogenic mutations were identified in all 6 MLS cases, including novel mutations. Chorein immunoreactions were significantly reduced in MLS erythrocyte membranes. In addition, we demonstrated a possible interaction between the chorein and XK protein via molecular analysis. The reduction in chorein expression is similar to that between Kell antigens and XK protein, although the chorein-XK interaction is a possibly noncovalent binding unlike the covalent Kell-XK complex. Our results suggest that reduced chorein levels following lack of XK protein are possibly associated with molecular pathogenesis in MLS.

PubMed

Other Link： https://ng.neurology.org/content/5/3/e328

中村雅之, 佐野輝 . 【知っておきたい器質性・症状性・薬剤性の精神障害:Update】精神症状を伴う神経変性疾患 . 臨床精神医学48 ( 1 ) 75 - 81 2019.1Invited

中村雅之, 石塚貴周, 佐野輝 . 私の論文から　臨床表現型に違いを呈したプレセニリン1遺伝子P264L変異を持つ兄妹例 . 九州神経精神医学64 ( 2 ) 96 - 99 2018.8Invited

Nagata O, Nakamura M, Sakimoto H, Urata Y, Sasaki N, Shiokawa N, Sano A . Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece. . Biochem Biophys Res Commun 2018.6Reviewed

佐野　輝 . 精神科専門医を目ざす人への助言　精神科専門医を目指す人への助言 . 九州神経精神医学63 ( 3-4 ) 174 - 175 2017.12Invited

林岳宏, 吉牟田直孝, 大毛葉子, 塩川奈理, 佐野輝 . 私のカルテから　抗精神病薬持効性注射剤導入の適応を考える　同居家族に精神疾患がある場合 . 九州神経精神医学63 ( 3-4 ) 182 - 185 2017.12

Language：Japanese Publisher：九州精神神経学会

同居家族に精神疾患のある統合失調症患者に対し、持効性注射剤(アリピプラゾール)の導入により、患者の精神症状の安定と同居家族の負担軽減が図られ、自宅退院や就労に至った2例を報告した。症例1は兄が統合失調症の26歳女性、症例2は長女が適応障害の35歳女性である。いずれの症例でも、同居家族の精神疾患が、患者の症状に明らかに影響していたと考えられた。持効性注射剤の長所として、「毎日の服用が不要である」「不慮あるいは意図的な過量服薬のリスクが減少する」などが挙げられるが、同居家族に精神疾患が存在する当症例のようなケースでは、持効性注射剤の導入によりお互いに「内服ができているだろうか」と心配することがなくなり、誤って家族の薬を内服するリスクを減らすことができるほか、他の家族にとっても内服管理の必要がなくなることは大きなメリットであると考えられた。

石島洋輔, 新井薫, 肝付洋, 中村雅之, 佐野輝 . 発熱・白血球増多を伴うカタトニアを呈した急速交代型双極性障害の1例 . 精神医学59 ( 10 ) 943 - 948 2017.10

Language：Japanese Publisher：(株)医学書院

カタトニア(緊張病)は,さまざまな精神疾患や身体疾患を背景に生じ,精神運動の失調を来す症候群である。DSM-5ではカタトニアが特定用語となり,統合失調症以外の疾患にも適応が広がった。また,発熱や自律神経失調を呈するカタトニアは悪性カタトニアと呼ばれ,抗精神病薬による悪性症候群との関連性が議論されている。我々は双極性障害の症例において,発熱と白血球増多がカタトニアに先行し,カタトニアの改善とともに消退した現象を観察した。本症例は悪性カタトニアの症候を部分的に呈しており,非悪性と悪性カタトニアの連続性が示唆された。また,発熱・白血球増多に着目することは,カタトニアの早期診断に寄与すると考えられた。(著者抄録)

中村雅之, 佐野輝 . プリオン病による認知症/軽度認知障害 . 日本臨床　別冊精神医学症候群III 195 - 203 2017.9Invited

新井薫, 肝付洋, 春日井基文, 中村雅之, 佐野輝 . 回避・制限性食物摂取障害にrisperidoneが有効であった1例 . 精神医学59 ( 1 ) 91 - 94 2017.1

Language：Japanese Publisher：(株)医学書院

回避・制限性食物摂取障害(avoidant/restrictive food intake disorder;ARFID)はDSM-5において追加されたボディイメージの歪みがない摂食障害である。思春期発症のARFIDの19歳女性の1例を提示する。患者は腹部の手術と腸閉塞の既往を持ち,15歳から食後の腹痛を恐れて食事を制限するようになった。SSRIやbenzodiazepineで治療されたが十分に反応しなかった。19歳時にrisperidone 1mgの投与を契機に腹痛に対する不安が軽減し,食事摂取が可能になった。ARFIDに対して抗精神病薬が治療の選択肢となり得ることが示唆された。(著者抄録)

Sainohira Kazutaka, Ishizuka Takanori, Tabata Kentaro, Yokotsuka Saeko, Arai Kaoru, Shiokawa Nari, Kasugai Motofumi, Nakamura Masayuki, Sano Akira . A Case of Hyperostosis Frontalis Interna with Frontal Lobe Dysfunction . Kyushu Neuropsychiatry63 ( 2 ) 88 - 93 2017

Language：Japanese Publisher：The Association of Kyushu Neuropsychiatry

<p>Hyperostosis frontalis interna (HFI) is characterized by the bilateral thickening of the frontal bone of the skull. Although most patients with HFI show no clinical symptoms, a few have been reported to show diverse and non-specific symptoms, including－but not limited to－cognitive decline, epileptic seizure, and endocrine disorder. We experienced the case of an 80-year-old woman with cognitive decline, in whom HFI was discovered on MRI and CT. Neurophychiatric examinations revealed frontal lobe dysfunction. HFI was therefore suggested to be one of the causes of frontal lobe dysfunction.</p>

DOI： 10.11642/kyushuneurop.63.2_88

CiNii Research

若松美貴代, 中村雅之, 春日井基文, 肝付洋, 沖利通, 折田有史, 戸上真一, 小林裕明, 佐野輝, 堂地勉 . Postpartum Depression Predictors Inventory-Revised(PDPI-R)(Predictive validity of the Japanese version of Postpartum Depression Predictors Inventory-Revised(PDPI-R) during pregnancy and the postpartum period) . 鹿児島大学医学紀要68 ( 1-3 ) 9 - 19 2016.12Reviewed

Sasaki N, Nakamura M, Kodama A, Urata Y, Shiokawa N, Hayashi T, Sano A . Chorein interacts with α-tubulin and histone deacetylase 6, and overexpression preserves cell viability during nutrient deprivation in human embryonic kidney 293 cells . FASEB Journal30 3726 - 3732 2016.11Reviewed

Language：English Publishing type：Research paper (scientific journal)

The autophagy pathway has recently been implicated in several neurodegenerative diseases. Recently, it was reported that chorein-depleted cells showed accumulation of autophagic markers and impaired autophagic flux. Here, we demonstrate that chorein overexpression preserves cell viability from starvation-induced cell death in human embryonic kidney 293 (HEK293) cells. Subsequent coimmunoprecipitation and reverse coimmunoprecipitation assays using extracts from chorein that stably overexpressed HEK293 cells revealed that chorein interacts with α-tubulin and histone deacetylase 6, a known α-tubulin deacetylater and central component of basal autophagy. Indeed, acetylated α-tubulin immunoreactivity was significantly decreased in chorein that stably overexpressed HEK293 cells. These results suggest that chorein/histone deacetylase 6/α-tubulin interactions may play an important role in starvation-induced cell stress, and their disruption may be one of the molecular pathogenic mechanisms of chorea-acanthocytosis.-Sasaki, N., Nakamura, M., Kodama, A., Urata, Y., Shiokawa, N., Hayashi, T., Sano, A. Chorein interacts with α-tubulin and histone deacetylase 6, and overexpression preserves cell viability during nutrient deprivation in human embryonic kidney 293 cells.

DOI： 10.1096/fj.201500191RR

PubMed

Yoshimuta H, Nakamura M, Kanda E, Fujita S, Takeuchi K, Fujimoto T, Nakabeppu Y, Akasaki Y, Sano A . The effects of olanzapine treatment on brain regional glucose metabolism in neuroleptic-naive first-episode schizophrenic patients . Hum Psychopharmacol31 ( 6 ) 419 - 426 2016.11Reviewed

佐野輝 . 評伝　佐野勇　精神神経医学に神経化学的光を当て、世界を股にかけた豪傑医学者 . 臨床精神医学45 ( 10 ) 1303 - 1305 2016.10Invited

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Papers - SANO Akira