Faculty Profiles - SANO Akira

Papers - SANO Akira

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Nishizawa Y., Sakimoto H., Nagata O., Sasaki N., Urata Y., Arai K., Hiwatashi H., Yokoyama I., Kishida S., Sano A., Nakamura M. . Chorein deficiency promotes ferroptosis . FEBS Open Bio15 ( 1 ) 58 - 68 2025.1Reviewed

Authorship：Lead author,　Last author,　Corresponding author Language：Japanese Publisher：FEBS Open Bio

Ferroptosis is a type of programmed cell death owed to an intracellular accumulation of iron resulting in the generation reactive oxygen species, which in turn can cause peroxidation of plasma membrane lipids and ultimately result in cell death. We investigated the potential involvement of VPS13A deficiency in ferroptosis. The VPS13A gene encodes for chorein, and its deficiency is a molecular cause of chorea-acanthocytosis (ChAc), a Huntington-like disease with neurodegeneration in the striatum. In our previous study, we found male infertility characterized by increased malondialdehyde staining of the spermatozoa in the testes of the ChAc model mice. Thus, in this study we performed metabolome analysis of sperm extracted from the epididymis of the ChAc model mice, which revealed decreased cystine levels, suggesting an association between chorein deficiency and ferroptosis. We then investigated the role of chorein in ferroptosis using VPS13A knockdown (VPS13A-KD) HEK293 cells. We found that VPS13A-KD cells displayed a significantly diminished resistance to tert-Butyl hydroperoxide (tBHP)-induced lipid peroxidation and cell death compared to control cells, which could be rescued by treatment with ferrostatin-1. Moreover, VPS13A-KD cells showed Fe(II) accumulation, suggesting an impaired capacity for divalent iron removal. In the cytosolic fraction of VPS13A-KD cells, the protein level of glutathione peroxidase 4 (GPX4) was significantly reduced, suggesting that dysfunction of chorein impairs GPX4 transport, thereby facilitating ferroptosis. These results suggest that ferroptosis may contribute to neurodegeneration in ChAc caused by loss of chorein function.

DOI： 10.1002/2211-5463.13870

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Ishiura H, Doi K, Mitsui J, Yoshimura J, et al. . Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy. . Nature Genetics50 ( 4 ) 581 - 590 2018.4Reviewed

Ueno S, Maruki Y, Nakamura M, Tomemori Y, Kamae K, Tanabe H, Yamashita Y, Matsuda S, Kaneko S and Sano A . The gene encoding a newly discovered protein, chorein, is mutated in chorea-acanthocytosis . Nature Genetics28 ( 2 ) 121 - 122 2001.6Reviewed

Nagafuchi S, Yanagisawa H, Sato K, Shirayama T, Ohsaki E, Bundo M, Takeda T, Tadokoro K, Kondo I, Murayama N, Tanaka Y, Kikushima H, Umino K, Kurosawa H, Furusawa T, Nihei K, Inoue T, Sano A, Komure O, Yoshizawa T, Kanazawa I, and Yamada M . Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p . Nature Genetics6 14 - 18 1994.1Reviewed

Akira Sano . Challenges and Reform Directions for National Universities 20 Years After Incorporation . 21 ( 8 ) 24 - 28 2025.11Invited

The Role of Chorein Deficiency in Late Spermatogenesis . Biomedicines12 240 2024.1Reviewed

佐野輝 . 精神医学・医療の移ろい . 九州神経精神医学69 ( 1 ) 1 - 2 2023.12

Sakimoto H, Urata Y, Ishizuka T, Kimotsuki H, Kasugai M, Fukuhara R, Sano A, Nakamura M . Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22 . PCN Reports2 ( 2 ) e92 2023.5Reviewed International journal

Arai K., Sakimoto H., Urata Y., Kariya M., Nakamura T., Ikehata T., Shimojima R., Furue N., Ishizuka T., Sano A., Nakamura M. . Aging-Related Catatonia with Reversible Dopamine Transporter Dysfunction in Females with Depressive Symptoms: A Case Series . American Journal of Geriatric Psychiatry31 ( 12 ) 1200 - 1205 2023Reviewed

Authorship：Lead author,　Last author,　Corresponding author Language：Japanese Publisher：American Journal of Geriatric Psychiatry

Objectives: The authors describe five depressive patients with initially decreased striatal accumulation of dopamine transporter (DAT) single-photon emission computed tomography (SPECT), which improved in parallel with clinical symptoms. Methods: Patients who exhibited decreased striatal accumulation and recovery of DATSPECT were identified among patients with the symptoms of depression. Their clinical and neuroimaging data were reviewed. Results: Five patients were identified. All patients were presenile or senile women who presented with catatonia subsequent to symptoms of depression that remitted with treatment. DAT-SPECT showed a decreased striatal accumulation in all patients, which increased after treatment. Two patients had met the diagnostic criteria of probable dementia with Lewy bodies (DLB), but no longer did so after their symptoms improved. Conclusions: Reversible DAT dysfunction observed in this study suggests that reversible impairment of dopaminergic transmission in the striatum partly underlies catatonia. Careful consideration should be given to diagnosing DLB in patients with decreased DAT-SPECT accumulation, especially when catatonia is present.

DOI： 10.1016/j.jagp.2023.05.009

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Mikiyo Wakamatsu, Masayuki Nakamura, Tsutomu Douchi, Motofumi Kasugai, Shinpei Kodama, Akira Sano, Hiroaki Kobayashi . Predicting postpartum depression by evaluating temperament during pregnancy . Journal of Affective Disorders292 720 - 724 2021.9Reviewed

Language：Japanese Publishing type：Research paper (scientific journal)

Aim: : The purpose of this study was to investigate premorbid temperaments to predict postpartum depression in pregnant women with no previous psychiatric history and to clarify the correlation between postpartum depression and the factors included in the Postpartum Depression Predictors Inventory-Revised (PDPI-R) and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto questionnaire (TEMPS-A)/Munich Personality Test (MPT). Methods: : A total of 170 eligible pregnant women filled out both questionnaires, the first between the 8th and 23rd week of gestation, and the latter between the 34th and 38th week of gestation. Participants filled out The Edinburgh Postnatal Depression Scale (EPDS) one month postpartum to measure for postpartum depression symptoms. All participants delivered full-term healthy babies. Results: : Seventeen (10%) women met the criteria for postpartum depression with a score of 9 or higher on the EDPS. The factors significantly related to developing postpartum depression were schizoid and melancholic temperament on the TEMPS-A/MPT and marital dissatisfaction on the PDPI-R. The total score on the PDPI-R was significantly correlated with depressive, cyclothymic, irritable, and anxious temperaments on the TEMPS-A/MPT. A lack of social support on the PDPI-R was significantly correlated with depressive, irritable, and anxious temperaments on the TEMPS-A/MPT. Conclusion: : The findings suggest that postpartum depression may be related to schizoid and melancholic temperaments and marital dissatisfaction. The hyperthymic temperament was identified as a significant predictor in preventing PPD. Careful observation during puerperium is recommended if a pregnant woman is likely to have these temperaments or psychological conditions. Temperament evaluation should be done during pregnancy as a form of postpartum depression screening.

DOI： 10.1016/j.jad.2021.05.106

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Yokotsuka-Ishida Saeko, Nakamura Masayuki, Tomiyasu Yoko, Nagai Mio, Kato Yuko, Tomiyasu Akiyuki, Umehara Hiromi, Hayashi Takehiro, Sasaki Natsuki, Ueno Shu-ichi, Sano Akira . Positional cloning and comprehensive mutation analysis identified a novel KDM2B mutation in a Japanese family with minor malformations, intellectual disability, and schizophrenia(和訳中) . Journal of Human Genetics66 ( 6 ) 597 - 606 2021.6Reviewed

Language：English Publisher：Nature Publishing Group

Marfan症候群様小奇形(MPA)、知的障害および統合失調症(SCZ)を呈した、日本人家系の遺伝子変異について報告した。一塩基多型(SNP)アレイと全エクソームシークエンシングを用いて、ポジショナルクローニングを行った結果、KDM2B遺伝子のPHDドメイン領域エクソン15に、本家系で発症要因と推定されるミスセンス変異(rs1555289644, NM_032590.4: c.2173G>A, p.A725T)が検出された。また、エクソームシークエンシングにより、コード領域内では、KDM2B遺伝子内に検出された唯一の点突然変異が、全ゲノム関連解析から、最も高い対数オッズスコア2.41が示された領域内に存在することが明らかにされた。さらに、ハプロタイプ解析により、罹患家族構成員4例に共分離が認められ、c.2173G>A変異を有する発端者由来リンパ芽球様細胞株でのKDM2B遺伝子発現量は、健常対照者の約半分であることが判明した。以上より、本家系では、発達過程でのKDM2B遺伝子のハプロ不全により、MPA、知的障害およびSCZが発症したと推測された。

Terasaki A, Nakamura M, Urata Y, Hiwatashi H, Yokoyama I, Yasuda T, Onuma T, Wada K, Kaneko S, Kan R, Niwa SI, Hashimoto O, Komure O, Goto YI, Yamagishi Y, Nakano M Furusawa Y, Sano A . DNA analysis of benign adult familial myoclonic epilepsy reveals associations between the pathogenic TTTCA repeat insertion in SAMD12 and the non-pathogenic TTTTA repeat expansion in TNRC6A . Journal of Human Genetics 66 ( 4 ) 419 - 429 2021.4Reviewed

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Benign adult familial myoclonic epilepsy (BAFME) is an autosomal dominant disease characterized by adult-onset tremulous hand movement, myoclonus, and infrequent epileptic seizures. Recently, intronic expansion of unstable TTTCA/TTTTA pentanucleotide repeats in SAMD12, TNRC6A, or RAPGEF2 was identified as pathological mutations in Japanese BAFME pedigrees. To confirm these mutations, we performed a genetic analysis on 12 Japanese BAFME pedigrees. A total of 143 participants, including 43 familial patients, 5 suspected patients, 3 sporadic nonfamilial patients, 22 unaffected familial members, and 70 unrelated controls, were screened for expanded abnormal pentanucleotide repeats in SAMD12, TNRC6A, RAPGEF2, YEAT2, MARCH6, and STARD7. DNA samples were analyzed using Southern blotting, long-range polymerase chain reaction (PCR), repeat-primed PCR, and long-range PCR followed by Southern blotting. Of the 51 individuals with clinically diagnosed or suspected BAFME, 49 carried a SAMD12 allele with an expanded TTTCA/TTTTA pentanucleotide repeat. Genetic and clinical anticipation was observed. As in previous reports, the one patient with homozygous mutant alleles showed more severe symptoms than the heterozygous carriers. In addition, screening for expanded pentanucleotide repeats in TNRC6A revealed that the frequency of expanded TTTTA repeat alleles in the BAFME group was significantly higher than in the control group. All patients who were clinically diagnosed with BAFME, including those in the original family reported by Yasuda, carried abnormally expanded TTTCA/TTTTA repeat alleles of SAMD12. Patients with BAFME also frequently carried a TTTTA repeat expansion in TNRC6A, suggesting that there may be unknown factors in the ancestry of patients with BAFME that make pentanucleotide repeats unstable.

DOI： 10.1038/s10038-020-00855-0

Umehara Hiromi, Nakamura Masayuki, Nagai Mio, Kato Yuko, Ueno Shu-ichi, Sano Akira . Positional cloning and comprehensive mutation analysis of a Japanese family with lithium-responsive bipolar disorder identifies a novel DOCK5 mutation . Journal of Human Genetics66 ( 3 ) 243 - 249 2021.3Reviewed

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Publishing Group

3世代にわたる日本人1家系21例から、健常者10例と統合失調性感情障害1例およびアルコール依存症1例、双極性障害(BD)3例および再発性大うつ病性障害(MDD)3例を対象とし、遺伝的影響が強いと予測される稀少な機能獲得性変異を特定した。100KのSNPアレイとマイクロサテライトマーカーを用いてゲノムワイド連鎖解析を行い、家系内の連鎖領域を指定し、これら連鎖領域内での遺伝子変異を特定するため、BD患者2例の全エキソーム配列決定を行い、DNA変異との共分離を解析した。その結果、最終的にDOCK5遺伝子のエキソン31領域に、機能獲得性変異を示唆する稀少なヘテロ接合変異(c.3170A>G, p.E1057G)が特定された。また、機能ゲノム解析により、DOCK5遺伝子が気分状態や自殺傾向を示すバイオマーカーの1つであることが明らかにされた。DOCK5遺伝子の機能は不明だが、本解析結果から、BDとDOCK5遺伝子との病理学的関係性が指摘された。

DOI： 10.1038/s10038-020-0

中村雅之、佐野輝 . 神経有棘赤血球症 . 生体の科学71 ( 5 ) 392 - 393 2020.10

Kasamo Kei, Nakamura Masayuki, Daimou Yoko, Sano Akira . 複数の遺伝子におけるPRIMPOL変異および変異体は慢性進行性外眼筋麻痺症候群の家族性症例の表現型に関与する(A PRIMPOL mutation and variants in multiple genes may contribute to phenotypes in a familial case with chronic progressive external ophthalmoplegia symptoms) . Neuroscience Research157 58 - 63 2020.8Reviewed

Language：English Publisher：エルゼビア・ジャパン(株)

複数の筋肉ミトコンドリアDNAの欠失、眼瞼下垂、糖尿病、難聴、精神遅滞および情緒不安定を特徴とする慢性進行性外眼筋麻痺症候群様症状を持つ家族について報告した。発端者は69歳男性であった。発達障害と精神遅滞があり、眼瞼下垂や難聴、心室肥厚、運動感覚ニューロパチーがみられた。71歳時に死亡した。家族の核遺伝子変異を特定するために遺伝子解析を行った。その結果、PRIMPOL、BRCA1、CPT2およびGJB2遺伝子における病原性変異の可能性と、CARD8およびMEFV遺伝子における機能的多型が認められた。複数の機能的多型と可能性のある病原性変異は、ミトコンドリア病様表現型に複合的に関与する可能性があると考えられた。

Tada Y, Hamaguchi T, Ikeda Y, Iwasa K, Nishida Y, Nakamura M, Sano A, and Yamada M . Chorea-acanthocytosis with a novel mutation in the vacuolar protein sorting 13 homolog a gene: A case report . J Neurol Sci412 116731 2020.5Reviewed

Futamura A, Nakamura M, Kawamura M, Sano A, and Ono K . Novel VPS13A Gene Mutations in a South Asian, Indian Patient with Chorea‑acanthocytosis. . Neurol India68 ( 206 ) 208 2020.2Reviewed

Urata Y, Nakamura M, Shiokawa N, Yasuniwa A, Takamori N, Imamura K, Hayashi T, Ishizuka T, Sano A . Sleep disorders in four patients with myotonic dystrophy type 1 . Front Neurol11 12 2020.2Reviewed

中島健二、祖父江元、長谷川一子、饗場郁子、青木正志、阿部康二、池内健、小野寺理、梶龍兒、吉良潤一、桑原聡、小久保康昌、斎藤加代子、佐々木秀直、佐野輝、高橋良輔、辻省次、戸田達史、中川正法、野元正弘、服部信孝、村田美穂、村山繁雄、望月秀樹、森田光哉、横田隆徳、吉田眞理、渡辺保裕、保住功（Huntington病の診断、治療、療養の手引きガイドライン作成委員会） . Huntington病の診断、治療、療養の手引き . 神経治療学37 61 - 104 2020.1Invited

Takenobu Murakami, Dan Abe, Hideyuki Matsumoto, Ryo Tokimura, Mitsunari Abe, Amanda Tiksnadi, Shunsuke Kobayashi, Chikako Kaneko, Yuka Urata, Masayuki Nakamura, Akira Sano, Yoshikazu Ugawa . A patient with McLeod syndrome showing involvement of the central sensorimotor tracts for the legs . BMC Neurology19 ( 1 ) 301 2019.11Reviewed

© 2019 The Author(s). Background: McLeod syndrome is a rare X-linked recessive acanthocytosis associated with neurological manifestations including progressive chorea, cognitive impairment, psychiatric disturbances, seizures, and sensorimotor axonal polyneuropathy. However, no studies have investigated the functioning of central sensorimotor tracts in patients with McLeod syndrome. Case presentation: A 66-year-old man had experienced slowly progressive chorea and gait disturbance due to lower limb muscle weakness since his early fifties. Blood examinations showed erythrocyte acanthocytosis and the reduction of Kell antigens in red blood cells. Brain magnetic resonance imaging showed atrophy of the bilateral caudate nuclei and putamen. The diagnosis of McLeod syndrome was confirmed by the presence of a mutation of the XK gene on the X chromosome. Somatosensory-evoked potential and transcranial magnetic stimulation studies demonstrated that the central sensory and motor conduction times were abnormally prolonged for the lower extremity but normal for the upper extremity. Conclusions: This is the first report of the involvement of the central sensorimotor tracts for the legs in a patient with McLeod syndrome. The clinical neurophysiological technique revealed the central sensorimotor tracts involvements clinically masked by neuropathy.

DOI： 10.1186/s12883-019-1526-9

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Suzuki F, Sato N, Ota M, Sugiyama A, Shigemoto Y, Morimoto E, Kimura Y, Wakasugi N, Takahashi Y, Futamura A, Kawamura M, Ono K, Nakamura M, Sano A, Watanabe M, Matsuda H, Abe O . Discriminating chorea-acanthocytosis from Huntington's disease with single- case voxel-based morphometry analysis . J Neurol Sci408 116545 2019.10Reviewed

佐野　輝 . 【現代医学・生物学の先駆者たち】神経科学　佐野勇(1924-1975)　精神神経医学に神経化学の光を当てた医学者 . 生体の科学70 ( 5 ) 458 - 459 2019.10Invited

Kawaike Y, Nagata J, Furuya T, Koriyama C, Nakamura M, Sano A . Working memory-related prefrontal hemodynamic responses in university students: A correlation study of subjective well-being and lifestyle habits. . Front Behav Neurosci 2019.9Reviewed

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Identification of social risk factors and the promotion of stress coping mechanisms and mental resilience are topics of interest in the field of mental health. The relationships between risk- or tolerability-associated factors and task-related hemodynamic responses in the prefrontal cortex (PFC) in adolescents may have important implications for mental health challenges. The purpose of this study was to investigate the relationship between task-related PFC hemodynamic activities and subjective well-being or lifestyle habits using wearable near-infrared spectroscopy (NIRS). In this study, after sample refinement to reduce heterogeneity, 20 university students were included in verbal working memory (VWM) task analyses and 21 were included in spatial working memory (SWM) task analyses. The task-related hemodynamic responses were detected using wearable NIRS. To assess the risk- or tolerability-associated factors, the levels of positive and negative affect were assessed using the Subjective Well-Being Inventory (SUBI) and lifestyle habits (such as gaming) were evaluated using a nine-item questionnaire. There was a positive correlation between SUBI positive affect and VWM task-related oxy-hemoglobin signal changes in the right dorsolateral PFC (DLPFC), underlining the significance of subjective well-being as an important independent emotional domain and suggesting the possibility of the differential objective evaluations of subjective well-being in the right PFC. Negative correlations between PFC activities during both VWM and SWM tasks at the left DLPFC and the number of game playing days in 1 week were also statistically significant, suggesting the presence of modality-non-specific hemodynamic regulation by habitual game playing. Each correlation was still robust after the elimination of major confounding impacts. Although further replication studies are warranted to confirm these preliminary results, this investigation of the relationship between task-related PFC hemodynamic activities and emotional domains or lifestyle habits might have clinical significance with regard to primary prevention of mental health issues in university students. To our knowledge, this is the first demonstration of these relationships with the use of wearable NIRS, which enables measurement under near natural conditions and is easy to use in schools or workplaces.

Keywords: wearable near-infrared spectroscopy, working memory, subjective well-being, lifestyle, university students, mental health

DOI： 10.3389/fnbeh.2019.00213

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中村雅之, 佐野輝 . 【指定難病ペディア2019】個別の指定難病　神経・筋系　神経有棘赤血球症[指定難病9] . 日本医師会雑誌148 ( 特別1 ) S114 2019.6

Nishida Y, Nakamura M, Urata Y, Kasamo K, Hiwatashi H, Yokoyama I, Mizobuchi M, Sakurai K, Osaki Y, Morita Y, Watanabe M, Yoshida K, Yamane K, Miyakoshi N, Okiyama R, Ueda T, Wakasugi N, Saitoh Y, Sakamoto T, Takahashi Y, Shibano K, Tokuoka H, Hara A, Monma K, Ogata K, Kakuda K, Mochizuki H, Arai T, Araki M, Fujii T, Tsukita K, Sakamaki-Tsukita H, MD, and Sano A . Novel pathogenic VPS13A gene mutations in Japanese patients with chorea-acanthocytosis. . Neurol Genet5 e332 2019.5Reviewed

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE:
To identify mutations in vacuolar protein sorting 13A (VPS13A) for Japanese patients with suspected chorea-acanthocytosis (ChAc).
METHODS:
We performed a comprehensive mutation screen, including sequencing and copy number variation (CNV) analysis of the VPS13A gene, and chorein Western blotting of erythrocyte ghosts. As the results of the analysis, 17 patients were molecularly diagnosed with ChAc. In addition, we investigated the distribution of VPS13A gene mutations and clinical symptoms in a total of 39 molecularly diagnosed Japanese patients with ChAc, including 22 previously reported cases.
RESULTS:
We identified 11 novel pathogenic mutations, including 1 novel CNV. Excluding 5 patients with the unknown symptoms, 97.1% of patients displayed various neuropsychiatric symptoms or forms of cognitive dysfunction during the course of disease. The patients carrying the 2 major mutations representing over half of the mutations, exon 60-61 deletion and exon 37 c.4411C>T (R1471X), were localized in western Japan.
CONCLUSIONS:
We identified 13 different mutations in VPS13A, including 11 novel mutations, and verified the clinical manifestations in 39 Japanese patients with ChAc.

DOI： 10.1212/NXG.0000000000000332

PubMed

中村雅之, 佐野輝 . 【プライマリーケアに役立つ　うつ・不安・不眠の診療】不安　抗不安薬の種類と使い方 . 臨牀と研究96 ( 5 ) 539 - 544 2019.5Invited

Yuka Urata, Masayuki Nakamura, Natsuki Sasaki, Nari Shiokawa, Yoshiaki Nishida, Kaoru Arai, Hanae Hiwatashi, Izumi Yokoyama, Shinsuke Narumi, Yasuo Terayama, Takenobu Murakami, Yoshikazu Ugawa, Hiroki Sakamoto, Satoshi Kaneko, Yusuke Nakazawa, Ryo Yamasaki, Shoko Sadashima, Toshiaki Sakai, Hiroaki Arai, Akira Sano . Novel pathogenic XK mutations in McLeod syndrome and interaction between XK protein and chorein . Neurol Genet5 e328 2019.4Reviewed

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Objective To identify XK pathologic mutations in 6 patients with suspected McLeod syndrome (MLS) and a possible interaction between the chorea-acanthocytosis (ChAc)- and MLS-responsible proteins: chorein and XK protein.

Methods Erythrocyte membrane proteins from patients with suspected MLS and patients with ChAc, ChAc mutant carriers, and normal controls were analyzed by XK and chorein immunoblotting. We performed mutation analysis and XK immunoblotting to molecularly diagnose the patients with suspected MLS. Lysates of cultured cells were co-immunoprecipitated with anti-XK and anti-chorein antibodies.

Results All suspected MLS cases were molecularly diagnosed with MLS, and novel mutations were identified. The average onset age was 46.8 ± 8 years, which was older than that of the patients with ChAc. The immunoblot analysis revealed remarkably reduced chorein immunoreactivity in all patients with MLS. The immunoprecipitation analysis indicated a direct or indirect chorein-XK interaction.

Conclusions In this study, XK pathogenic mutations were identified in all 6 MLS cases, including novel mutations. Chorein immunoreactions were significantly reduced in MLS erythrocyte membranes. In addition, we demonstrated a possible interaction between the chorein and XK protein via molecular analysis. The reduction in chorein expression is similar to that between Kell antigens and XK protein, although the chorein-XK interaction is a possibly noncovalent binding unlike the covalent Kell-XK complex. Our results suggest that reduced chorein levels following lack of XK protein are possibly associated with molecular pathogenesis in MLS.

PubMed

Other Link： https://ng.neurology.org/content/5/3/e328

中村雅之, 佐野輝 . 【知っておきたい器質性・症状性・薬剤性の精神障害:Update】精神症状を伴う神経変性疾患 . 臨床精神医学48 ( 1 ) 75 - 81 2019.1Invited

中村雅之, 石塚貴周, 佐野輝 . 私の論文から　臨床表現型に違いを呈したプレセニリン1遺伝子P264L変異を持つ兄妹例 . 九州神経精神医学64 ( 2 ) 96 - 99 2018.8Invited

Nagata O, Nakamura M, Sakimoto H, Urata Y, Sasaki N, Shiokawa N, Sano A . Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece. . Biochem Biophys Res Commun 2018.6Reviewed

佐野　輝 . 精神科専門医を目ざす人への助言　精神科専門医を目指す人への助言 . 九州神経精神医学63 ( 3-4 ) 174 - 175 2017.12Invited

林岳宏, 吉牟田直孝, 大毛葉子, 塩川奈理, 佐野輝 . 私のカルテから　抗精神病薬持効性注射剤導入の適応を考える　同居家族に精神疾患がある場合 . 九州神経精神医学63 ( 3-4 ) 182 - 185 2017.12

Language：Japanese Publisher：九州精神神経学会

同居家族に精神疾患のある統合失調症患者に対し、持効性注射剤(アリピプラゾール)の導入により、患者の精神症状の安定と同居家族の負担軽減が図られ、自宅退院や就労に至った2例を報告した。症例1は兄が統合失調症の26歳女性、症例2は長女が適応障害の35歳女性である。いずれの症例でも、同居家族の精神疾患が、患者の症状に明らかに影響していたと考えられた。持効性注射剤の長所として、「毎日の服用が不要である」「不慮あるいは意図的な過量服薬のリスクが減少する」などが挙げられるが、同居家族に精神疾患が存在する当症例のようなケースでは、持効性注射剤の導入によりお互いに「内服ができているだろうか」と心配することがなくなり、誤って家族の薬を内服するリスクを減らすことができるほか、他の家族にとっても内服管理の必要がなくなることは大きなメリットであると考えられた。

石島洋輔, 新井薫, 肝付洋, 中村雅之, 佐野輝 . 発熱・白血球増多を伴うカタトニアを呈した急速交代型双極性障害の1例 . 精神医学59 ( 10 ) 943 - 948 2017.10

Language：Japanese Publisher：(株)医学書院

カタトニア(緊張病)は,さまざまな精神疾患や身体疾患を背景に生じ,精神運動の失調を来す症候群である。DSM-5ではカタトニアが特定用語となり,統合失調症以外の疾患にも適応が広がった。また,発熱や自律神経失調を呈するカタトニアは悪性カタトニアと呼ばれ,抗精神病薬による悪性症候群との関連性が議論されている。我々は双極性障害の症例において,発熱と白血球増多がカタトニアに先行し,カタトニアの改善とともに消退した現象を観察した。本症例は悪性カタトニアの症候を部分的に呈しており,非悪性と悪性カタトニアの連続性が示唆された。また,発熱・白血球増多に着目することは,カタトニアの早期診断に寄与すると考えられた。(著者抄録)

中村雅之, 佐野輝 . プリオン病による認知症/軽度認知障害 . 日本臨床　別冊精神医学症候群III 195 - 203 2017.9Invited

新井薫, 肝付洋, 春日井基文, 中村雅之, 佐野輝 . 回避・制限性食物摂取障害にrisperidoneが有効であった1例 . 精神医学59 ( 1 ) 91 - 94 2017.1

Language：Japanese Publisher：(株)医学書院

回避・制限性食物摂取障害(avoidant/restrictive food intake disorder;ARFID)はDSM-5において追加されたボディイメージの歪みがない摂食障害である。思春期発症のARFIDの19歳女性の1例を提示する。患者は腹部の手術と腸閉塞の既往を持ち,15歳から食後の腹痛を恐れて食事を制限するようになった。SSRIやbenzodiazepineで治療されたが十分に反応しなかった。19歳時にrisperidone 1mgの投与を契機に腹痛に対する不安が軽減し,食事摂取が可能になった。ARFIDに対して抗精神病薬が治療の選択肢となり得ることが示唆された。(著者抄録)

Sainohira Kazutaka, Ishizuka Takanori, Tabata Kentaro, Yokotsuka Saeko, Arai Kaoru, Shiokawa Nari, Kasugai Motofumi, Nakamura Masayuki, Sano Akira . A Case of Hyperostosis Frontalis Interna with Frontal Lobe Dysfunction . Kyushu Neuropsychiatry63 ( 2 ) 88 - 93 2017

Language：Japanese Publisher：The Association of Kyushu Neuropsychiatry

<p>Hyperostosis frontalis interna (HFI) is characterized by the bilateral thickening of the frontal bone of the skull. Although most patients with HFI show no clinical symptoms, a few have been reported to show diverse and non-specific symptoms, including－but not limited to－cognitive decline, epileptic seizure, and endocrine disorder. We experienced the case of an 80-year-old woman with cognitive decline, in whom HFI was discovered on MRI and CT. Neurophychiatric examinations revealed frontal lobe dysfunction. HFI was therefore suggested to be one of the causes of frontal lobe dysfunction.</p>

DOI： 10.11642/kyushuneurop.63.2_88

CiNii Research

若松美貴代, 中村雅之, 春日井基文, 肝付洋, 沖利通, 折田有史, 戸上真一, 小林裕明, 佐野輝, 堂地勉 . Postpartum Depression Predictors Inventory-Revised(PDPI-R)(Predictive validity of the Japanese version of Postpartum Depression Predictors Inventory-Revised(PDPI-R) during pregnancy and the postpartum period) . 鹿児島大学医学紀要68 ( 1-3 ) 9 - 19 2016.12Reviewed

Sasaki N, Nakamura M, Kodama A, Urata Y, Shiokawa N, Hayashi T, Sano A . Chorein interacts with α-tubulin and histone deacetylase 6, and overexpression preserves cell viability during nutrient deprivation in human embryonic kidney 293 cells . FASEB Journal30 3726 - 3732 2016.11Reviewed

Language：English Publishing type：Research paper (scientific journal)

The autophagy pathway has recently been implicated in several neurodegenerative diseases. Recently, it was reported that chorein-depleted cells showed accumulation of autophagic markers and impaired autophagic flux. Here, we demonstrate that chorein overexpression preserves cell viability from starvation-induced cell death in human embryonic kidney 293 (HEK293) cells. Subsequent coimmunoprecipitation and reverse coimmunoprecipitation assays using extracts from chorein that stably overexpressed HEK293 cells revealed that chorein interacts with α-tubulin and histone deacetylase 6, a known α-tubulin deacetylater and central component of basal autophagy. Indeed, acetylated α-tubulin immunoreactivity was significantly decreased in chorein that stably overexpressed HEK293 cells. These results suggest that chorein/histone deacetylase 6/α-tubulin interactions may play an important role in starvation-induced cell stress, and their disruption may be one of the molecular pathogenic mechanisms of chorea-acanthocytosis.-Sasaki, N., Nakamura, M., Kodama, A., Urata, Y., Shiokawa, N., Hayashi, T., Sano, A. Chorein interacts with α-tubulin and histone deacetylase 6, and overexpression preserves cell viability during nutrient deprivation in human embryonic kidney 293 cells.

DOI： 10.1096/fj.201500191RR

PubMed

Yoshimuta H, Nakamura M, Kanda E, Fujita S, Takeuchi K, Fujimoto T, Nakabeppu Y, Akasaki Y, Sano A . The effects of olanzapine treatment on brain regional glucose metabolism in neuroleptic-naive first-episode schizophrenic patients . Hum Psychopharmacol31 ( 6 ) 419 - 426 2016.11Reviewed

佐野輝 . 評伝　佐野勇　精神神経医学に神経化学的光を当て、世界を股にかけた豪傑医学者 . 臨床精神医学45 ( 10 ) 1303 - 1305 2016.10Invited

Benninger F, Afawi Z, Korczyn AD, Oliver KL, Pendziwiat M, Nakamura M, Sano A, Helbig I, Berkovic SF, Blatt I . Seizures as presenting and prominent symptom in chorea-acanthocytosis with c.2343del VPS13A gene mutation . Epilepsia57 549 - 556 2016.4Reviewed International coauthorship

Sakimoto H, Nakamura M, Nagata O, Yokoyama I, Sano A . Phenotypic abnormalities in a chorea-acanthocytosis mouse model are modulated by strain background . Biochem Biophys Res Commun472 118 - 124 2016.3Reviewed

Language：English Publishing type：Research paper (scientific journal)

Chorea-acanthocytosis (ChAc) is an autosomal recessive hereditary disease characterized by neurodegeneration in the striatum and acanthocytosis that is caused by mutations in the VPS13A gene. We previously produced a ChAc model mice encoding a human disease mutation with deletion of exons 60-61 in the VPS13A gene. The behavioral and pathological phenotypes of the model mice varied a good deal from individual to individual, indicating that differences between individuals may be caused by the content of a genetic hybrid 129/Sv and C57BL/6J strain background. To establish the effect of the genetic background on phenotype, we backcrossed the ChAc-model mice to different inbred strains: C57BL/6J and 129S6/Sv. Although no significant difference between ChAc-mutant mice and wild-type mice on the C57BL/6J background was observed, the ChAc-mutant mice on the 129S6/Sv showed abnormal motor function and behavior. Furthermore, we produced ChAc-mutant mice on two different inbred strains: BALB/c and FVB. Significant reduction in weight was observed in ChAc mutant mice on the FVB and 129S6 backgrounds. We found a marked increase in the osmotic fragility of red blood cells in the ChAc mutant mice backcrossed to 129S6/Sv and FVB. The phenotypes varied according to strain, with ChAc mutant mice on the FVB and 129S6 backgrounds showing remarkably abnormal motor function and behavior. These results indicate that there are modifying genetic factors of ChAc symptoms.

佐野輝 . 【精神科専門医制度に望むこと】大学病院の立場から . 精神科28 ( 1 ) 78 - 80 2016.1Invited

Narumi1 S, Natori T, MiyazawaH, Kato T, Yonezawa H, Nishino I, Nakamura M, Sano A and Terayama Y . A case of McLeod syndrome with novel genetic mutation . Neurology and Clinical Neuroscience4 115 - 117 2016Reviewed

Sakiyama Y, Kanda N, Higuchi Y, Yoshimura M, Wakaguri H, Takata Y, Watanabe O, Yuan J, Tashiro Y, Saigo R, Nozuma S, Yoshimura A, Arishima S, Ikeda K, Shinohara K, Arata H, Michizono K, Higashi K, Hashiguchi A, Okamoto Y, Hirano R, Shiraishi T, Matsuura E, Okubo R, Higuchi I, Goto M, Hirano H, Sano A, Iwasaki T, Matsuda F, Izumo S, Takashima H . New type of encephalomyelitis responsive to trimethoprim/sulfamethoxazole treatment in Japan . Neurol Neuroimmunol Neuroinflamm 2015.8Reviewed

Language：English Publishing type：Research paper (scientific journal)

Objective:

To determine the causative pathogen and investigate the effective treatment of a new type of encephalomyelitis with an unknown pathogen in Japan and report the preliminary ultrastructural and genomic characterization of the causative agent.

Methods:

From 2005 to 2012, we treated 4 Japanese patients with geographic clustering and comparable clinical features, serum/CSF cytology, and radiologic findings. Brain biopsy was conducted in all patients to analyze neuropathologic changes by histology, and electron microscopy was applied to reveal the features of the putative pathogen. Genomic DNA was obtained from the affected brain tissues and CSF, and an unbiased high-throughput sequencing approach was used to screen for specific genomic sequences indicative of the pathogen origin.

Results:

All patients exhibited progressive dementia with involuntary tongue movements. Cytologic examination of CSF revealed elevated mononuclear cells. Abnormal MRI signals were observed in temporal lobes, subcortical white matter, and spinal cord. Biopsied brain tissue exhibited aggregated periodic acid-Schiff–positive macrophages and 2–7 μm diameter round/oval bodies without nuclei or cell walls scattered around the vessels. Unbiased high-throughput sequencing identified more than 100 archaea-specific DNA fragments. All patients were responsive to trimethoprim/sulfamethoxazole (TMP-SMX) plus corticosteroid therapy.

Conclusions:

We report 4 cases of encephalomyelitis due to an unknown pathogen. On the basis of ultrastructural and genomic studies, we propose a new disease entity resulting from a causative pathogen having archaeal features. TMP-SMX therapy was effective against this new type of encephalomyelitis.

DOI： 10.1212/NXI.0000000000000143

PubMed

石塚貴周, 中村雅之, 崎元仁志, 瀬戸下玄郎, 春日井基文, 佐野輝 . 認知症症状を呈した高齢初発てんかん4例 . 精神科25 ( 5 ) 555 - 560 2014.11Reviewed

Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal)

認知症との鑑別を要した高齢初発てんかん4例について報告した。症例は症例1(69歳女性)、症例2(65歳女性)、症例3(60歳男性)、症例4(62歳女性)であった。全例共通の症状として、旅行や孫の運動会のエピソードごと忘れている等の記憶障害を認め、さらに意欲低下や易怒性亢進等の精神症状を伴っていた。脳波では左側頭部に焦点のある突発波が確認された。症例3は安静覚醒時脳波では明らかな突発波は確認できず、終夜睡眠脳波にのみ確認された。抗てんかん薬の治療により、全例症状の改善を認めた。高齢初発てんかんの頻度は高く、明らかなてんかん発作様式をとらない、持続性の記憶障害や日常生活能力低下を呈する例が少なからずあることが指摘できた。けいれん発作を伴わず、記憶が挿間性にエピソードごと抜けている等の経過や発作的な記憶障害が疑われる症例については、高齢初発てんかんを念頭に置き、安静覚醒時脳波で突発波がなくても睡眠脳波まで確認する必要が示唆された。

高取由紀子, 鮫島稔弥, 兒玉晃子, 児玉圭, 楠本朗, 春日井基文, 赤崎安昭, 佐野輝 . 精神疾患患者における身体的治療の同意についての問題提起　特徴的な4症例を通して . 総合病院精神医学26 ( 4 ) 397 - 403 2014.10Reviewed

春日井基文、福田恭哉、竹之内薫、山畑良蔵、赤崎安昭、佐野輝 . 医療観察法入院処遇対象者の身体合併症に対する総合病院精神科における治療構造設定と問題点． . 臨床精神医学43 ( 9 ) 1269 - 1272 2014.9Reviewed

Shiokawa N, Nakamura M, Sameshima M, Deguchi A, Hayashi T, Sasaki N, Sano A . Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin. . Biochem Biophys Res Commun 441, 96-101, 2013441 ( 1 ) 96 - 101 2013.11Reviewed

楠本朗、児玉圭、吉田巌、赤崎安昭、森岡洋史、佐野輝 . 職場不適応事例に対する治療的アプローチ . 臨床精神医学42 ( 10 ) 1231 - 1237 2013.10Reviewed

楠本朗、赤崎安昭、赤崎安隆、井料学、福迫剛、宇多英典、冨永秀文、川元孝久、西俣寿人、佐野輝 . メンタルヘルス健診の問題点について－鹿児島県における労働者のメンタルヘルスの取り組みを通して－ . 臨床精神医学 42, 1193-1199, 201342 ( 10 ) 1193 - 1199 2013.10Reviewed

Sangatsuda Y, Nakamura M, Tomiyasu A, Deguchi A, Toyota Y, Goto YI, Nishino I, Ueno SI, Sano A . Heteroplasmic m.1624C>T mutation of the mitochondrial tRNA(Val) gene in a proband and his mother with repeated consciousness disturbances. . Mitochondrion12 ( 6 ) 617 - 622 2012.11Reviewed

Ishizuka T, Nakamura M, Ichiba M, Fujita S, Takeuchi K, Fujimoto T, and Sano A . Different clinical phenotypes in siblings with a presenilin-1 P264L mutation. . Dement Geriatr Cogn Disord33 ( 42038 ) 132 - 140 2012.5Reviewed

Hayashi T, Kishida M, Nishizawa Y, Iijima M, Koriyama C, Nakamura M, Sano A, and Kishida S . Subcellular localization and putative role of VPS13A/chorein in dopaminergic neuronal cells. . Biochem Biophys Res Commun419 ( 3 ) 511 - 516 2012.2Reviewed

Deguchi A, Nakamura M, Hayashi T, and Sano A . Quetiapine-induced frequent premature ventricular contraction. . Gen Hosp Psychiatry34 ( 2 ) 2110 - 211000 2012.1Reviewed

松田三恵子、富永雅孝、児玉圭、小玉哲史、中村雅之、赤崎安昭、佐野輝 . 小脳橋角部腫瘍に伴い強迫症状の出現・消退を認めた症例 . 精神科19 ( 5 ) 521 - 525 2011.11Reviewed

Mori S, Nakamura M, Yasuda T, Ueno SI, Kaneko S, Sano A . Remapping and mutation analysis of benign adult familial myoclonic epilepsy in a Japanese pedigree . J Hum Genet56 ( 10 ) 742 - 747 2011.10Reviewed

Xue B, Chen J, Gao H, Saito S, Kobayashi N, Shimokawa T, Nabeka H, Sano A, Matsuda S . Chronological changes in prosaposin in the developing rat brain . Neurosci Res71 ( 1 ) 22 - 34 2011.9Reviewed

Takata A, Kato M, Nakamura M, Yoshikawa T, Kanba S, Sano A, Kato T . Exome sequencing identifies a novel missense variant in RRM2B associated with autosomal recessive progressive external ophthalmoplegia . Genome Biol12 ( 9 ) R92 2011.9Reviewed

Ishizuka T, Nakamura M, Ichiba M, Sano A . Familial Semantic Dementia with P301L Mutation in the Tau Gene . Dement Geriatr Cogn Disord31 ( 5 ) 334 - 340 2011.7Reviewed

Tomiyasu A, Nakamura M, Ichiba M, Ueno S, Saiki S, Morimoto M, Kobal J, Kageyama Y, Inui T, Wakabayashi K, Yamada T, Kanemori Y, Jung HH, Tanaka H, Orimo S, Afawi Z, Blatt I, Aasly J, Ujike H, Babovic-Vuksanovic D, Josephs KA, Tohge R, Rodrigues GR, Dupre N, Yamada H, Yokochi F, Kotschet K, Takei T, Rudzinska M, Szczudlik A, Penco S, Fujiwara M, Tojo K, Sano A . Novel pathogenic mutations and copy number variations in the VPS13A gene in patients with chorea-acanthocytosis . Am J Med Genet B Neuropsychiatr Genet156 ( 5 ) 620 - 631 2011.7Reviewed International coauthorship

Kato M, Nakamura M, Ichiba M, Tomiyasu A, Shimo H, Higuchi I, Ueno S, Sano A . Mitochondrial DNA deletion mutations in patients with neuropsychiatric symptoms. . Neurosci Res69 ( 4 ) 331 - 336 2011.4Reviewed

Shimo H, Nakamura M, Tomiyasu A, Ichiba M, Ueno S, Sano A . Comprehensive analysis of the genes responsible for neuroacanthocytosis in mood disorder and schizophrenia. . Neurosci Res69 ( 3 ) 196 - 202 2011.3Reviewed

Hayashi T, Nakamura M, Ichiba M, Matsuda M, Kato M, Shiokawa N, Shimo H, Tomiyasu A, Mori S, Tomiyasu Y, Ishizuka T, Inamori Y, Okamoto Y, Umehara F, Arimura K, Nakabeppu Y, and Sano A . Adult-type metachromatic leukodystrophy with compound heterozygous ARSA mutations: A case report and phenotypic comparison with a previously reported case. . Psychiat Clin Neurosci65 ( 1 ) 105 - 108 2011.2Reviewed

赤崎安昭、森岡洋史、楠本朗ら、吉田巌、春日井基文、佐野輝 . 裁判員制度における鑑定人への「尋問」に対する提言 . 精神科17 ( 4 ) 418 - 423 2010.10Reviewed

楠本朗、赤崎安昭、鮫島稔弥、春日井基文、吉田巌、森岡洋史、佐野輝 . 起訴前精神鑑定を担当する医師の中立性について . 精神科17 ( 3 ) 314 - 318 2010.9Reviewed

高取由紀子、鮫島稔弥、楠本朗、市場美緒、川池陽一、中村雅之、佐野輝 . Posterior Cortical Atrophy(PCA)が認められた認知症の1例脳画像所見および診断を含めて . 九州神経精神医学56 ( 2 ) 83 - 87 2010.8Reviewed

赤崎安昭、楠本朗、吉田巌、春日井基文、上村佳代、小山徹平、富永雅孝、佐野輝 . 「発作殺人」に至った症例に関する考察 . 精神科17 ( 1 ) 86 - 95 2010.7Reviewed

瀬戸下玄郎、春日井基文、赤崎安昭、佐野輝 . 治療関係の構築が困難であった妄想型統合失調症の一症例 . Schizophrenia Frontier111 ( 2 ) 142 - 145 2010.6Reviewed

川池陽一、堀切靖、赤崎安昭、森岡洋史、佐野輝 . 精神科診断の問題点￢-フォーカシングの観点からー . 臨床精神医学39 ( 3 ) 347 - 352 2010.3Reviewed

川池陽一、森岡洋史、佐野輝 . フォーカシングを診療に生かす . 臨床精神医学39 ( 1 ) 77 - 84 2010.1Reviewed

新井薫、肝付洋, 春日井基文, 中村雅之, 佐野輝 . 回避・制限性食物摂取障害にrisperidoneが有効であった1例 . 精神医学59 ( 1 ) 91 - 94 2010.1Reviewed

森岡洋史、赤崎安昭、川床貴史、児玉圭、堀切靖、佐野輝 . 大学における不登校問題について卒業論文でつまずいた3症例から. . 精神科15 ( 6 ) 578 - 585 2009.12Reviewed

市場美緒、林岳宏、富安昭之、中村雅之、橋口知、赤崎安昭、佐野輝 . 強迫症状を認めたvelocardiofacial syndromeの1症例 . 強迫性障害の研究10 13 - 18 2009.5Reviewed

林岳宏、佐々木なつき、川池陽一、中村雅之、小玉哲史、室屋真二、木原貴士、赤崎安昭、佐野輝 . リスペリドン内服中に単源性多発性の心室性期外収縮がみられた初発統合失調症の症例 . 九州神経精神医学55 ( 1 ) 9 - 15 2009.4Reviewed

赤崎安昭、中村雅之、佐野輝 . 大学・精神科紹介12 鹿児島大学大学院医歯学総合研究科精神機能病学分野． . 最新精神医学13 517 - 524 2008.1

伊地知明、中村雅之、市場美緒、倉野裕、橋口渡、小玉哲史、赤崎安昭、竹之内薫、中別府良昭、佐野輝 . 激しい自殺企図に至ったアルツハイマー型認知症の一例. . 精神科12 133 - 138 2008.1

石田康、長友慶子、池田学、内村直尚、大内清、小澤寛樹、北村俊則、近藤毅、赤崎安昭、佐野輝、寺尾岳、西村良二、山田茂人、神庭重信、中村純 . プライマリケア医のうつ病診療に関する実態調査. . 九州神経精神医学54 120 - 126 2008.1Reviewed

赤崎安昭、森岡洋史、畑幸宏、児玉圭、中村雅之、小玉哲史、室屋真二、冨吉リカ、川池陽一、井上賢人、富永雅孝、橋口渡、和田学、新里研吾、佐野輝 . 鹿児島県における司法精神医学の現状と課題（第２報） -成年後見制度に基づく精神鑑定に関するアンケート調査を通じて-. . 九州神経精神医学54 101 - 113 2008.1Reviewed

赤崎安昭、森岡洋史、秦幸宏、筒井順子、三好順子、佐野輝 . 拡大自殺により実子を殺害したうつ病者に関する考察. . 臨床精神医学37 1201 - 1212 2008.1Reviewed

赤崎安昭、児玉圭、森岡洋史、福迫剛、上山健一、佐野輝 . 【触法精神障害者のアセスメントと治療】鹿児島県における司法精神医学の現状と課題　司法精神医学教育システムおよびネットワークの確立に向けて . 臨床精神医学36 ( 9 ) 1083 - 1091 2007.9Reviewed

松久保秀幸、小玉哲史、橋口渡、中崎満浩、中別府良昭、赤池浩一、赤崎安昭、佐野輝 . パニック障害として紹介されたインスリノーマの1症例　診断とSPECT所見について . 精神科10 ( 6 ) 511 - 517 2007.6Reviewed

赤崎安昭、児玉圭、中村雅之、小玉哲史、橋口知、森岡洋史、堂地勉、佐野輝 . 【コンサルテーション・リエゾン精神医学　産婦人科との連携】精神疾患を合併した女性患者の出産　28症例の後方視的調査を通して . 総合病院精神医学19 ( 2 ) 151 - 165 2007.5Reviewed

川池陽一、赤崎安昭、森岡洋史、堀切靖、佐野輝 . フォーカシングの観点からみた「服薬」という行為に関する1考察強迫性障害の治療を通して . 臨床精神病理28 ( 1 ) 29 - 37 2007.4Reviewed

倉野裕、中村雅之、市場美緒、水野恵三子、松田三恵子、加藤真依子、出雲周二、佐野輝 . 有棘赤血球舞踏病病因遺伝子産物Choreinの発現と局在、およびGephyrinとGABA受容体との関係について . 精神薬療研究年報39 ( ※ ) 9 - 15 2007.3

佐野のぞみ、佐野輝 . 【てんかん児の生活支援と看護】知っておきたい知識てんかんの定義と原因 . 小児看護30 ( 2 ) 138 - 144 2007.2

河野奈理、市場美緒、竹之内薫、佐野輝 . 前頭側頭葉変性症の経験例についての臨床的検討 . 鹿児島高次脳機能研究会会誌18 ( ※ ) 32 - 36 2007.1

赤崎安昭、森岡洋史、吉牟田泰史、赤池浩一、神田英介、小玉哲史、上村清央、藤田晴吾、竹内康三、藤元登四郎、佐野輝 . 加害強迫を主症状とする強迫性障害の一考察 -治療前後のPET所見も含めて- . 強迫性障害の研究8 ( ※ ) 47 - 58 2007.1Reviewed

佐野輝(SanoAkira) . 鹿児島県における司法精神鑑定の現状と課題医療観察法運用上の問題提起も含めて . 九州神経精神医学52 ( 2 ) 115 - 125 2006Reviewed

下洋央、橋口渡、中村雅之、中別府良昭、佐野輝 . 抑うつ状態を呈した糖原病Ia型の1症例 . 九州神経精神医学52 ( 3&4 ) 175 - 181 2006Reviewed

児玉圭、赤崎安昭、井上賢人、神田英介、浦村一秀、小玉哲史、赤池浩一、堂地勉、佐野輝 . 精神疾患合併妊婦の出産出産直前に妊娠が発覚した症例も含めて . 九州神経精神医学52 ( 3&4 ) 182 - 190 2006Reviewed

室屋真二、市場美緒、加藤ゆう子、水野恵美子、倉野裕、中村雅之、上野修一、佐野輝 . CHAC(VPS13A)遺伝子異常による精神神経障害の多因子性に関する研究 . 精神薬療研究年報38 ( ※ ) 122 - 125 2006

橋口渡、赤崎安昭、楠本朗、富永雅孝、赤池浩一、堀切靖、森岡洋史、佐野輝 . 口角を押し上げ続ける行為がみられた症例の診断と考察 . 強迫性障害の研究7 ( ※ ) 23 - 29 2006Reviewed

竹之内薫、赤崎安昭、森岡洋史、佐野輝 . 触法精神障害者の1鑑定例殺人に至った特異な経緯について . 精神科治療学9 ( 3 ) 269 - 273 2006Reviewed

赤崎安昭、神田英介、浦村一秀、赤池浩一、富永雅孝、堀切靖、小玉哲史、佐野輝 . 精神疾患合併妊婦の出産 . 日本産科婦人科学会鹿児島地方部会雑誌13 ( ※ ) 1 - 5 2005Reviewed

市場美緒、室屋真二、水野恵美子、楠本朗、留守ゆう子、中村雅之、佐野輝 . 半優性遺伝形式を示した有棘赤血球舞踏病の一家系 . 精神薬療研究年報37 ( ※ ) 35 - 41 2005

神田英介、赤崎安昭、赤池浩一、富永雅孝、川池陽一、小玉哲史、堀切靖、森岡洋史、佐野輝 . 自己臭を初発症状とした統合失調症と考えられる1症例 . 心療内科9 ( 4 ) 279 - 283 2005Reviewed

中村雅之、佐野輝 . 統合失調症 . 分子細胞治療4 60 - 66 2005

赤崎安昭、森岡洋史、堀切靖、橋口渡、川池陽一、小玉哲史、赤池浩一、佐野輝 . 【強迫性障害の研究】「縁起」が主題となった強迫性障害患者の治療と考察 . 強迫性障害の研究6 ( ※ ) 111 - 117 2005Reviewed

赤崎安昭、森岡洋史、松本聡子、富永雅孝、橋口渡、赤池浩一、堀切靖、佐野輝 . 強迫性障害の診断と治療に関する一考察髪の毛が薄いと確信する思春期症例を通して . 精神科7 ( 2 ) 166 - 175 2005Reviewed

吉牟田泰史、市場美緒、筒井順子、橋口渡、浦村一秀、中別府良昭、赤崎安昭、竹之内薫、佐野輝 . アルツハイマー型痴呆として治療されていた意味性痴呆の1症例 . 九州神経精神医学51 ( 2 ) 113 - 121 2005Reviewed

松久保秀幸、橋口渡、赤池浩一、橋口知、赤崎安昭、佐野輝 . 精神障害者の身体合併症治療に関する調査鹿児島県における現況 . 九州神経精神医学51 ( 3&4 ) 163 - 169 2005Reviewed

S. Ueno, K. Kamae, Y. Yamashita, Y. Maruki, Y. Tomemori, M. Nakamura, M. Ikeda H. Tanabe, and A. Sano . Chorea-acanthocytosis with the Ehime-deletion mutation . Neuroacanthocytosis Syndromes※ ( ※ ) 39 - 44 2004

江川さおり、赤崎安昭、水野謙太郎、橋口渡、高橋正明、森岡洋史、佐野輝 . 妊娠34週に発症した急性一過性精神病性障害の1症例 . 九州神経精神医学50 ( 2 ) 118 - 124 2004Reviewed

佐野輝(SanoAkira) . 有棘赤血球舞踏病病因遺伝子CHACの疾患モデルマウスの表現型解析 . 精神薬療研究年報36 ( ※ ) 66 - 73 2004

井上賢人、赤崎安昭、森岡洋史、赤池浩一、小玉哲史、白谷敏宏、堀切靖、佐野輝 . 緊張病症候群が疑われた若年周期精神病の1症例 . 九州神経精神医学50 ( 1 ) 46 - 51 2004Reviewed

吉牟田泰史、赤池浩一、橋口知、小玉哲史、川池陽一、白谷敏宏、中別府良昭、赤崎安昭、佐野輝 . ペニシリンG療法後のセフトリアキソン追加療法で脳血流の改善を示した進行麻痺の1症例 . 精神科5 ( 2 ) 156 - 162 2004Reviewed

市場美緒、赤崎安昭、富永雅孝、堀切靖、白谷敏宏、佐野輝 . Paroxetineが著効した身体表現性障害の3症例 . 九州神経精神医学50 ( 2 ) 125 - 131 2004Reviewed

市場美緒、赤崎安昭、富永雅孝、赤池浩一、堀切靖、佐野輝 . Fluvoxamine投与中に全身性けいれんが認められた1症例 . 強迫性障害の研究5 ( ※ ) 95 - 99 2004Reviewed

Mihara K, Kondo T, Suzuki A, Yasui-Furukori N, Ono S, Sano A, Koshiro K, Otani K and Kaneko S . Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant syndrome . Am J Med Genet B Neuropsychiatr Genet117 ( 1 ) 57 - 60 2003.2Reviewed

赤池浩一、橋口知、松下素子、萩原敬史、駿河幸男、赤崎安昭、佐野輝 . SLE治療経過中に精神症状を呈した1症例抗リン脂質抗体症候群(APS)の合併について . 九州神経精神医学49 ( 2007/3/4 ) 184 - 191 2003Reviewed

佐野輝 . 精神神経疾患と有棘赤血球舞踏病遺伝子CHACの解析研究 . 精神薬療研究年報35 ( ※ ) 286 - 289 2003

赤崎安昭、森岡洋史、富永雅孝、橋口知、堀切靖、佐野輝 . 両親殺害及び放火に至った統合失調症患者の一考察司法精神鑑定を通して . 臨床精神医学32 ( 12 ) 1547 - 1555 2003Reviewed

Sakai K, Nakamura M, Ueno S, Sano A, Sakai N, Shirai Y and Saito N . The silencer activity of the novel human serotonin transporter linked polymorphic regions . Neurosci Lett327 ( 1 ) 13 - 16 2002.7Reviewed

佐野輝(SanoAkira) . ラット顔面神経切断後の顔面神経核内プロサポシン免疫反応の変化 . 愛媛医学21 ( 3 ) 296 - 300 2002.1Reviewed

Sano A, Mikami M, Nakamura M, Ueno S, Tanabe H and Kaneko S . Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy . Epilepsia※ ( 43 Suppl 9 ) 26 - 31 2002.1Reviewed

上野修一、留守ゆう子、繁信和恵、中村雅之、田邉敬貴、佐野輝 . 新たな痴呆関連遺伝子 CHACの分子遺伝学の研究 . 精神薬療研究年報34 ( ※ ) 206 - 212 2002.1

Suzuki A, Kondo T, Otani K, Mihara K, Yasui-Furukori N, Sano A, Koshiro K and Kaneko S . Association of the TaqI A polymorphism of the dopamine D(2) receptor gene with predisposition to neuroleptic malignant syndrome . Am J Psychiatry158 ( 10 ) 1714 - 1716 2001.10Reviewed

中村雅之、三神正昭、上野修一、佐野輝, 田邉敬貴 . トランスポーター遺伝子多型と精神疾患との関連研究(第2報) . 精神薬療研究年報33 ( ※ ) 257 - 262 2001.1

Nakamura M, Ueno S, Sano A and Tanabe H . The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants . Mol Psychiatry5 ( 1 ) 32 - 38 2000.1Reviewed

上野修一、佐野輝 . 【ゲノム時代の脳神経医学】分子遺伝学てんかんの分子遺伝学 . Molecular Medicine37 ( 臨増ゲノム時代の脳神経医学 ) 8 - 15 2000.1

中村雅之、三神正昭、上野修一、佐野輝, 田邉敬貴 . トランスポーター遺伝子多型と精神疾患との関連研究 . 精神薬療基金研究年報32 ( ※ ) 127 - 134 2000.1

佐野輝、三神正昭、安田雄、寺尾章、兼子直、田中敏博、後藤雄一、大沼悌一 . 新技術を用いたてんかん等の診断法と治療法の開発BAFMEの連鎖解析 . 厚生省精神・神経疾患研究委託費による11年度研究報告集※ ( ※ ) 3 - 3 2000.1

小林央、鈴木隆、辻省次、佐野輝、植木彰、遠藤耕太郎、長谷川精一、和知学、笹川睦男、細木俊宏、廣田紘一 . 新技術を用いたてんかん等の診断法と治療法の開発てんかんの分子遺伝学的研究Familial essential myoclonus and epilepsy(FEME)の連鎖解析 . 厚生省精神・神経疾患研究委託費による11年度研究報告集※ ( ※ ) 9 - 9 2000.1

Mikami M, Yasuda T, Terao A, Nakamura M, Ueno S, Tanabe H, Tanaka T, Onuma T, Goto Y, Kaneko S and Sano A . Localization of a gene for benign adult familial myoclonic epilepsy to chromosome 8q23.3-q24.1 . Am J Hum Genet65 ( 3 ) 745 - 751 1999.9Reviewed

Katsuragi S, Kunugi H, Sano A, Tsutsumi T, Isogawa K, Nanko S and Akiyoshi J . Association between serotonin transporter gene polymorphism and anxiety-related traits . Biological psychiatry45 ( 3 ) 368 - 370 1999.2Reviewed

Ueno S, Nakamura M, Mikami M, Kondoh K, Ishiguro H, Arinami T, Komiyama T, Mitsushio H, Sano A and Tanabe H . Identification of a novel polymorphism of the human dopamine transporter (DAT1) gene and the significant association with alcoholism . Mol Psychiatry4 ( 6 ) 552 - 557 1999.1Reviewed

Sato T, Oyake M, Nakamura K, Nakao K, Fukusima Y, Onodera O, Igarashi S, Takano H, Kikugawa K, Ishida Y, Shimohata T, Koide R, Ikeuchi T, Tanaka H, Futamura N, Matsumura R, Takayanagi T, Tanaka F, Sobue G, Komure O, Takahashi M, Sano A, Ichikawa Y, Goto J . Transgenic mice harboring a full-length human mutant DRPLA gene exhibit age-dependent intergenerational and somatic instabilities of CAG repeats comparable with those in DRPLA patients . Hum Mol Genet8 ( 1 ) 99 - 106 1999.1Reviewed

Nakamura M, Ueno S, Sano A and Tanabe H . Polymorphisms of the human homologue of the Drosophila white gene are associated with mood and panic disorders . Mol Psychiatry4 ( 2 ) 155 - 162 1999.1Reviewed

Kushihata F, Matsuda S, Sano A, Aburaya J, Shimahara Y, Kobayashi N and Sakanaka M . Expression of basic fibroblast growth factor-like immunoreactivity in the nuclei of regenerating hepatocytes. . Cell Tissue Res288 517 - 527 1997Reviewed

Prosaposin, a neurotrophic factor: presence and properties in milk . J Dairy Sci80 264 - 272 1997Reviewed International coauthorship

Ueno SI, Otani K, Kaneko S, Koshiro K, Kondoh K, Kotani Y and Sano A . Cytochrome P-450 2D6 gene polymorphism is not associated with neuroleptic malignant syndrome . 40 ( 72 ) - 74 1996.6Reviewed

Kotani Y, Matsuda S, Wen TC, Sakanaka M, Tanaka J, Maeda N, Kondoh K, Ueno SI and Sano A . A hydrophilic peptide comprising 18 amino acid residues of the prosaposin sequence has neurotrophic activity in vitro and in vivo . J Neurochem66 2197 - 2200 1996.5Reviewed

Prosaposin facilitates sciatic nerve regeneration in vivo . J Neurochem66 2019 - 2025 1996.5Reviewed

A unique origin and multistep process for the generation of expanded DRPLA triplet repeats . Hum Mol Genet5 373 - 379 1996.3Reviewed International coauthorship

Somatic mosaicism of CAG repeat in dentatorubral-pallidoluysian atrophy (DRPLA) . 1995.4

Komure O, Sano A, Nishino N, Yamauchi N, Ueno SI, Kondoh K, Sano N, Takahashi M, Murayama N, Kondo I, Nagafuchi S, Yamada M, and Kanazawa I . DNA analysis in hereditary dentatorubral-pallidoluysian atrophy: correlation between CAG repeat length and phenotypic variation and the molecular basis of anticipation . Neurology45 143 - 149 1995.1Reviewed

Ueno SI, Kotani Y, Kondoh K, Sano A, Kakimoto Y and Campagnoni AT . The 3'-untranslated region of mouse myelin basic protein gene increases the amount of mRNA in immortalized mouse oligodendrocytes . Biochem Biophys Res Commun204 1352 - 1357 1994.11Reviewed International coauthorship

Sano A, Matsuda S, Wen TC, Kotani Y, Kondoh K, Ueno SI, Kakimoto Y, Yoshimura H and Sakanaka M . Protection by prosaposin against ischemia-induced learning disability and neuronal loss . Biochem Biophys Res Commun204 994 - 1000 1994.10Reviewed

Sano A, Yamauchi N, Kakimoto Y, Komure O, Kawai J, Hazama F, Kuzume K, Sano N and Kondo I . Anticipation in hereditary dentatorubral-pallidoluysian atrophy . Hum Genet93 699 - 702 1994.6Reviewed

Kondoh K, Sano A, Kakimoto Y, Matsuda S and Sakanaka M . Distribution of prosaposin-like immunoreactivity in rat brain . J Comp Neurol334 590 - 602 1993.8Reviewed

A 40-nucleotide repeat polymorphism in the human dopamine transporter gene . 91 405 - 406 1993.5Reviewed

Itoh K, Takiyama N, Kase R, Kondoh K, Sano A, Oshima A, Sakuraba H and Suzuki Y . Purification and characterization of human lysosomal protective protein expressed in stably transformed Chinese hamster ovary cells . J Biol Chem268 ( 1180 ) 1186 1993.1Reviewed

Ueno SI, Sano A, Kotani K, Kondoh K and Kakimoto Y . Distribution of free methylarginines in rat tissues and in the bovine brain. . J Neurochem59 2012 - 2019 1992.12Reviewed

Saposin-C from bovine spleen; complete amino acid sequence and relation between the structure and its biological activity . Biochim Biophys Acta1120 75 - 80 1992.3Reviewed

Kotani K, Ueno SI, Sano A and Kakimoto Y . Isolation and identification of methylarginines from bovine brain . J Neurochem58 1127 - 1129 1992.3Reviewed

Kondoh K, Hineno T, Sano A and Kakimoto Y . Isolation and characterization of prosaposin from human milk . Biochem Biophys Res Commun181 286 - 292 1991.11Reviewed

Hineno T, Sano A, Kondoh K, Ueno SI, Kakimoto Y and Yoshida K . Secretion of sphingolipid hydrolase activator precursor, prosaposin . Biochem Biophys Res Commun176 668 - 674 1991.4Reviewed

Isolation and identification of alpha-(beta-alanyl)hypusine from bovine brain . Biochim Biophys Acta1073 233 - 235 1991.1Reviewed

Ueno SI, Sano A, Hineno T, Kondoh K, Mizuno T, Morino H and Kakimoto Y . Further studies on D-3-aminoisobutyrate-pyruvate aminotransferase . Biochim Biophys Acta1035 128 - 131 1990.8Reviewed

Ueno SI, Morino H, Sano A and Kakimoto Y . Purification and characterization of D-3-aminoisobutyrate-pyruvate aminotransferase from rat liver . Biochim Biophys Acta1033 128 - 131 1990.8Reviewed

Mizobuchi M, Miyake M, Sano A and Kakimoto Y . High concentration of free trimethyllysine in red blood cells . Biochim Biophys Acta1033 119 - 123 1990.2Reviewed

Sano A, Hineno T, Mizuno T, Kondoh K, Ueno SI, Kakimoto Y and Inui K . Sphingolipid hydrolase activator proteins and their precursors . Biochem Biophys Res Commun165 1191 - 1197 1989.12Reviewed

Radin NS, Shukla A, Shukla GS and Sano A . Heat-stable protein that stimulates acid alpha-glucosidase . Biochem J264 845 - 849 1989.12Reviewed International coauthorship

Sano A, Radin NS, Johnson LL and Tarr GE . The activator protein for glucosylceramide beta-glucosidase from guinea pig liver. Improved isolation method and complete amino acid sequence . J Biol Chem263 19597 - 19601 1988.12Reviewed International coauthorship

Sano A and Radin NS . The carbohydrate moiety of the activator protein for glucosylceramide beta-glucosidase . Biochem Biophys Res Commun154 1197 - 1203 1988.8Reviewed International coauthorship

Sano A and Radin NS . The inhibition of glucosylceramide beta-glucosidase and other acid hydrolases by nucleic acids . Biochem J254 297 - 300 1988.8Reviewed International coauthorship

Sano A, Kotani K, Ueno SI and Kakimoto Y . Distribution of alpha-(gamma-aminobutyryl)-hypusine . J Neurochem48 681 - 683 1987.3Reviewed

Sano A, Kotani K and Kakimoto Y . Isolation and identification of alpha-(gamma-aminobutyryl)-hypusine . J Neurochem46 1046 - 1049 1986.4Reviewed

Sano A, Miyake M and Kakimoto Y . A rapid and sensitive method for the determination of hypusine in proteins and its distribution and developmental changes . Biochim Biophys Acta800 135 - 139 1984.6Reviewed

Kikuchi A, Tomisaka S, Yonezawa K, Sano A, Yamamura H . Isolation and properties of casein kinases from human platelets . 3 477 - 481 1982Reviewed

Kii R, Sano A, Yonezawa K, Sakai K, Tabuchi H, Ku Y, Hashimoto E, Yamamura H and Nishizuka Y . Multiplicity of phosphate acceptor proteins for muscle glycogen phosphorylase kinase . J Biochem (Tokyo)88 1129 - 1134 1980.10Reviewed

Kii R, Sakai K, Sano A, Yonezawa K, Hashimoto E and Yamamura H . Inhibitory and stimulatory effects of guanyl-5'-yl imidodiphosphate on the adenylate cyclase activity of rat synaptosomal fractions . 80 267 - 271 1980.1Reviewed

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