研究者詳細 - 久徳　貴之

写真a

キュウトク　タカユキ

久徳　貴之

KYUTOKU Takayuki

所属

医歯学域附属病院附属病院診療センター感覚器センター助教

論文

Nagano H., Kiyama S., Kyutoku T., Matsumoto H., Yamashita M. . Genetic mutations in salivary duct carcinoma . Otolaryngologia Polska the Polish Otolaryngology80 ( 3 ) 1 - 7 2026年3月

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記述言語：日本語出版者・発行元：Otolaryngologia Polska the Polish Otolaryngology

Introduction: Although genetic mutations have been reported in salivary duct carcinoma (SDC), no scientifically validated targeted therapies are currently available. Moreover, cancer genomic profiling tests remain underutilized in clinical practice. These issues highlight the urgent need to elucidate the genomic landscape of SDC and its potential therapeutic relevance. Aim: This study aimed to characterize the mutational profile of recurrent and/or metastatic SDC. Materials and methods: Data were analyzed for 207 consecutive patients with SDC registered at the Japan National Cancer Center, Center for Cancer Genomics and Advanced Therapeutics (C-CAT) between June 2019 and October 2025. Genetic mutations were determined by next-generation sequencing. Survival of patients was determined by the log-rank test and the Cox proportional hazards model. Results: The top 10 mutations in SDC were TP53 (74.4%), ERBB2 (52.2%), NF1 (32.4%), CDK12 (29.0%), PIK3CA (28.0%), NOTCH3 (19.8%), LTK (18.4%), CDKN2A (18.4%), BRCA2 (16.9%), SPEN (16.9%), with 17.1 7.2 (mean standard error of the mean [SEM]) mutations/individual. TP53 mutations (p = 0.005707) were associated with a significantly worse prognosis, as determined by log-rank test. The hazard ratios for cases with this mutation was 2.6390 (95% CI, 1.2180-5.720, p = 0.0139) for TP53. Conclusions: This study delineated the mutational spectrum of recurrent and/or metastatic SDC. Even in advanced disease, prognostically relevant mutations were identified, emphasizing the clinical importance of cancer genomic profiling tests.

DOI： 10.5604/01.3001.0055.5900

Scopus

PubMed
Nagano H, Kiyama S, Takayuki K, Matsumoto H, Yamashita M . Genetic mutations in recurrent and/or metastatic nasal carcinoma: A pathological comparison based on the Japanese national genomic profiling database. . Otolaryngologia polska = The Polish otolaryngology80 ( 2 ) 1 - 8 2026年2月

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記述言語：英語

DOI： 10.5604/01.3001.0055.5235

PubMed
Nagano H., Kyutoku T., Matsumoto H., Ando Y., Yamashita M. . Epicutaneous sensitization in BALB/c mice induces stronger systemic Th2 inflammation than intranasal sensitization despite comparable nasal eosinophilia . Otolaryngologia Polska the Polish Otolaryngology80 ( 1 ) 1 - 8 2026年2月

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記述言語：日本語出版者・発行元：Otolaryngologia Polska the Polish Otolaryngology

Introduction: Epicutaneous sensitization (ES) plays a role in the onset of allergic diseases such as atopic dermatitis (AD), bronchial asthma, and food allergies, but its effects on nasal allergic diseases remain unclear. Aim: The aim of this study was to compare the effects of intranasal challenge following ES with those following intranasal sensitization (NS) on nasal allergic inflammation. Materials and methods: Female BALB/c mice were sensitized epicutaneously or intranasally with 25 μg of ovalbumin (OVA) and 2 μg of cholera toxin (CT) six times at weekly intervals. These groups were compared with control groups that received ES with phosphate- buffered saline (PBS) alone, OVA alone, or CT alone. Two weeks after the final sensitization, the mice were challenged intranasally with 500 μg of OVA ten times over a two-week period. Four weeks after the final sensitization, allergic inflammation in the nasal cavity, OVA-specific IgE production, and cytokine profiles were evaluated in the different groups. Results: Post-challenge, there was no significant difference in the number of eosinophils or the thickness of lateral nasal mucosa between the ES and NS groups. However, the serum level of OVA-specific IgE in the ES group was significantly higher than that in the control and NS groups. Levels of IL-4, IL-5, IL-13, and IL-33 in CD4+ T cells were also significantly higher in the ES group than in the NS group. Conclusions: These results indicate that intranasal challenge following ES induces comparable eosinophilic inflammation in the nasal cavity, but elicits a stronger systemic Th2-type inflammatory response than that following NS.

DOI： 10.5604/01.3001.0055.5830

Scopus

PubMed
山下勝, 喜山敏志, 宮下圭一, 川畠雅樹, 久徳貴之 . 気道からの大量出血を来したパラガングリオーマの症例 . 日本耳鼻咽喉科頭頸部外科学会会報128 ( 12 ) 1325 - 1330 2025年12月

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記述言語：日本語出版者・発行元：一般社団法人日本耳鼻咽喉科頭頸部外科学会

　パラガングリオーマ(PGL)は傍神経節から発生する神経内分泌腫瘍である.気道にて発見される症例はまれだが,血流が豊富な腫瘍であることから出血しやすく,適切な気道確保が行われない場合は死に至る可能性がある.われわれは,大量喀血を来したものの緊急気管切開により救命することのできた,声門下に発見されたPGLの1症例を経験した.気管切開後の腫瘍摘出術では腫瘍周囲に安全域を確保し,気管の窓状切除を行った.摘出術時に形成した気管皮膚瘻は,鼻中隔軟骨を遠位端に埋め込んだDP皮弁を用いて段階的に閉鎖した.過去の報告もあわせて,気道に発生したPGLについて報告する.

DOI： 10.3950/jibiinkotokeibu.128.12_1325

CiNii Research
喜山敏志, 宮下圭一, 川畠雅樹, 久徳貴之, 山下勝 . 気道からの大量出血を来したパラガングリオーマの症例 . 日本耳鼻咽喉科頭頸部外科学会会報128 ( 12 ) 1325 - 1330 2025年12月

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記述言語：日本語出版者・発行元：(一社)日本耳鼻咽喉科頭頸部外科学会

パラガングリオーマ(PGL)は傍神経節から発生する神経内分泌腫瘍である.気道にて発見される症例はまれだが,血流が豊富な腫瘍であることから出血しやすく,適切な気道確保が行われない場合は死に至る可能性がある.われわれは,大量喀血を来したものの緊急気管切開により救命することのできた,声門下に発見されたPGLの1症例を経験した.気管切開後の腫瘍摘出術では腫瘍周囲に安全域を確保し,気管の窓状切除を行った.摘出術時に形成した気管皮膚瘻は,鼻中隔軟骨を遠位端に埋め込んだDP皮弁を用いて段階的に閉鎖した.過去の報告もあわせて,気道に発生したPGLについて報告する.(著者抄録)
川畠雅樹, 久徳貴之, 田淵みな子, 大堀純一郎, 山下勝 . 黄色ブドウ球菌菌血症による全身多発膿瘍を伴った咽後膿瘍の1例 . 日本耳鼻咽喉科免疫アレルギー感染症学会抄録集5回 211 - 211 2025年4月

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記述言語：日本語出版者・発行元：日本耳鼻咽喉科免疫アレルギー感染症学会
Nagano H., Kiyama S., Kyutoku T., Matsumoto H., Yamashita M. . Genetic mutations in recurrent and/or metastatic squamous cell carcinoma of unknown primary – an analysis of the Japanese national genomic profiling database . Otolaryngologia Polska79 ( 6 ) 1 - 6 2025年1月

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記述言語：日本語出版者・発行元：Otolaryngologia Polska

Introduction: Although genetic mutations have been reported in squamous cell carcinoma of unknown primary (SCCUP), no scientifically validated targeted therapies are currently available. Moreover, cancer genomic profiling tests remain underutilized in clinical practice. These issues highlight the urgent need to elucidate the genomic landscape of SCCUP and its potential therapeutic relevance.Aim: This study aimed to characterize the mutational profile of recurrent and/or metastatic SCCUP.Materials and methods: Data were analyzed for 170 consecutive patients with SCCUP registered at the Japan National Cancer Center, Center for Cancer Genomics and Advanced Therapeutics (C-CAT) between June 2019 and August 2025. Genetic mutations were determined by next-generation sequencing. The survival of patients was determined by the log-rank test and a Cox proportional hazards model.Results: The top 10 mutations in SCCUP were TP53 (57.6%), CDKN2A (37.0%), PIK3CA (32.9%), KMT2D (27.6%), CDKN2B (20.6%), NOTCH3 (20.6%), BRAC2 (20.0%), PTEN (16.5%), NOTCH1 (15.9%), and RICTOR (15.9%), with 20.2 ±10.1 (mean ±SEM) mutations/ individual. Mutation in BRCA2 (p = 0.0347) was associated with a significantly worse prognosis, as determined by the log-rank test. The hazard ratios for cases with this mutation was 2.3450 (95% CI, 1.2220–4.499, p = 0.01037) for BRCA2.Conclusions: This study delineated the mutational spectrum of recurrent and/or metastatic SCCUP. Even in advanced disease, prognostically relevant mutations were identified, emphasizing the clinical importance of cancer genomic profiling tests.

DOI： 10.5604/01.3001.0055.3303

Scopus
Matsumoto H., Nagano H., Kyutoku T., Yamashita M. . Genetic Analysis of Melanoma Types Using Japanese Genomic Database . Laryngoscope135 ( 1 ) 134 - 139 2025年1月

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記述言語：日本語出版者・発行元：Laryngoscope

Objectives: The purpose of this study is to compare genetic mutations, tumor mutation burden (TMB), and the effects of molecular targeted drugs and immune checkpoint inhibitors (ICIs) in head and neck mucosal melanoma (HNMUM) with those in skin melanoma (SKM) and ocular melanoma (OM). Methods: Data were analyzed for 72 consecutive patients with HNMUM, including 366 with SKM and 31 with OM, registered at the Japan National Cancer Center, Center for Cancer Genomics and Advanced Therapeutics (C-CAT) between June 2019 and October 2023. Genetic alterations and TMB were determined by FoundationOne CDx next-generation sequencing. Results: The top 10 mutations in HNMUM were RAD21 (47.2%), NBN (45.8%), MYC (40.3%), LYN (31.9%), NRAS (29.1%), IRF4 (23.6%), DAXX (22.2%), KIT (22.2%), NOTCH3 (20.8%), and DDR1 (19.4%), with 16.6 ± 0.8 (mean ± SEM) mutations/individual. In SKM, BRAF (p = 0.04) mutation was associated with a significantly better prognosis. The TMB values were 5.7 ± 2.1 (mean ± SEM) in HNMUM, 4.1 ± 0.2 in SKM, and 3.4 ± 0.9 in OM, with no significant differences among the three groups. The median survival time for patients with distant metastases was 803 (95% confidence interval: 539-NA) days for HNMUM, 1413 (831–2172) days for SKM, and 1138 (438-NA) days for OM. Conclusions: The top 10 mutations in HNMUM are closer to those in OM than those in SKM. There was no significant difference in TMB values or survival rates with regard to the therapeutic effect of ICIs among the diseases, which suggests that current treatment of HNMUM with ICIs is appropriate. Level of Evidence: 3 Laryngoscope, 135:134–139, 2025.

DOI： 10.1002/lary.31676

Scopus

PubMed
田中智規, 宮下圭一, 徳重豪士, 久徳貴之, 松元隼人, 宮本佑美, 川畠雅樹, 永野広海, 大堀純一郎, 山下勝 . 重粒子線治療後晩発性に内頸動脈からの出血によりショックを発症した一例 . 日本鼻科学会会誌63 ( 3 ) 443 - 443 2024年9月

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記述言語：日本語出版者・発行元：(一社)日本鼻科学会
喜山敏志, 宮下圭一, 川畠雅樹, 久徳貴之, 大堀純一郎, 山下勝 . 気道からの大量出血を生じたパラガングリオーマの1例 . 耳鼻咽喉科臨床補冊 ( 補冊166 ) 151 - 151 2024年6月

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記述言語：日本語出版者・発行元：日本耳鼻咽喉科臨床学会
久徳貴之, 大堀純一郎, 山下勝 . 硬性気管支鏡下でバスケット鉗子を用いて除去した気管異物の一例 . 小児耳鼻咽喉科44 ( 2 ) 311 - 311 2023年10月

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記述言語：日本語出版者・発行元：日本小児耳鼻咽喉科学会
Nagano H., Kyutoku T., Matsumoto H., Kurono Y. . Sudden death after operation, radiotherapy, or chemoradiotherapy for head and neck cancer . Otolaryngologia Polska77 ( 1 ) 26 - 33 2023年2月

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記述言語：日本語出版者・発行元：Otolaryngologia Polska

Aim: The purpose of this report was to determine sudden death following operation, radiotherapy (RT), or chemoradiotherapy (CRT) for head and neck cancer. Material and methods: Data from 729 consecutive patients diagnosed with head and neck cancer (confirmed using multiple modalities) who underwent operation, RT, or CRT at Kagoshima University Hospital between April 2011, and March 2020 were analyzed. A total of 199 patients underwent operation, 223 patients underwent RT and 307 underwent CRT. A total of 175 patients who received operation, 118 patients who received RT, and 190 who received CRT showed a complete response. Results: There were 13 cases of sudden death reported in 10 years. 12 were male and 1 was female. Sudden death occurred in 3/175 patients (1.7%) who received operation, 4/118 (3.4%) who received RT, and 6/190 (3.1%) who received CRT. Conclusions: We present the first report on cases of sudden death after operation, RT, and CRT for head and neck cancer. Otolaryngologists should still follow these patients carefully after such a treatment given that sudden death does occur in some patients.

DOI： 10.5604/01.3001.0016.1487

Scopus

PubMed

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講演・口頭発表等

永野広海, 松元隼人, 安藤由実, 久徳貴之, 宮本佑美, 山下勝 . 頭頸部粘膜黒色腫と他領域黒色腫との遺伝子変異の比較検討 . 日本耳鼻咽喉科頭頸部外科学会会報 2024年4月 (一社)日本耳鼻咽喉科頭頸部外科学会

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記述言語：日本語
永野広海, 松崎尚寛, 伊東小都子, 松元隼人, 久徳貴之, 宮本佑美, 井内寛之, 馬越瑞夫, 川畠雅樹, 大堀純一郎, 山下勝 . 頭頸部癌における放射線治療および化学放射線療法後の突然死例の検討 . 日本耳鼻咽喉科学会会報 2021年4月 (一社)日本耳鼻咽喉科頭頸部外科学会

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記述言語：日本語
宮本佑美, 大堀純一郎, 松元隼人, 久徳貴之, 吉松誠芳, 川畠雅樹, 永野広海, 山下勝 . 若齢マウスの肺炎球菌ワクチン経鼻投与によるPolysaccharide特異的IgA誘導 . 耳鼻咽喉科ニューロサイエンス 2024年5月耳鼻咽喉科ニューロサイエンス研究会

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記述言語：日本語
永野広海, 松元隼人, 宮下圭一, 久徳貴之, 松崎尚寛, 喜山敏志, 大堀純一郎, 山下勝 . 経皮感作・経鼻曝露による鼻・副鼻腔炎症性疾患の発症について　経鼻感作・経鼻曝露との比較 . 日本耳鼻咽喉科頭頸部外科学会会報 2025年4月 (一社)日本耳鼻咽喉科頭頸部外科学会

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記述言語：日本語
Matsumoto Hayato, Nagano Hiromi, Ando Yumi, Kyutoku Takayuki, Miyamoto Yumi, Yamashita Masaru . 癌遺伝子パネルを用いた副鼻腔扁平上皮癌における遺伝子変異(Genetic mutations in sinonasal squamous cell carcinoma using oncogene panel) . 日本耳鼻咽喉科頭頸部外科学会会報 2024年4月 (一社)日本耳鼻咽喉科頭頸部外科学会

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記述言語：英語
松元隼人, 永野広海, 久徳貴之, 宮本佑美, 吉松誠芳, 川畠雅樹, 山下勝 . がん遺伝子パネル検査を用いた頭頸部扁平上皮癌の遺伝子変異についての検討 . 頭頸部癌 2024年5月 (一社)日本頭頸部癌学会

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記述言語：日本語

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