Language：Japanese   Publisher：Otolaryngologia Polska the Polish Otolaryngology  

<b>Introduction:</b> Although genetic mutations have been reported in salivary duct carcinoma (SDC), no scientifically validated targeted therapies are currently available. Moreover, cancer genomic profiling tests remain underutilized in clinical practice. These issues highlight the urgent need to elucidate the genomic landscape of SDC and its potential therapeutic relevance. <br><br><b>Aim:</b> This study aimed to characterize the mutational profile of recurrent and/or metastatic SDC. <br><br><b>Materials and methods:</b> Data were analyzed for 207 consecutive patients with SDC registered at the Japan National Cancer Center, Center for Cancer Genomics and Advanced Therapeutics (C-CAT) between June 2019 and October 2025. Genetic mutations were determined by next-generation sequencing. Survival of patients was determined by the log-rank test and the Cox proportional hazards model. <br><br><b>Results:</b> The top 10 mutations in SDC were <i>TP53</i> (74.4%), <i>ERBB2</i> (52.2%), <i>NF1</i> (32.4%), <i>CDK12</i> (29.0%), <i>PIK3CA</i> (28.0%), <i>NOTCH3</i> (19.8%), <i>LTK</i> (18.4%), <i>CDKN2A</i> (18.4%), <i>BRCA2</i> (16.9%), <i>SPEN</i> (16.9%), with 17.1 7.2 (mean standard error of the mean [SEM]) mutations/individual. <i>TP53</i> mutations (p = 0.005707) were associated with a significantly worse prognosis, as determined by log-rank test. The hazard ratios for cases with this mutation was 2.6390 (95% CI, 1.2180-5.720, p = 0.0139) for <i>TP53</i>. <br><br><b>Conclusions:</b> This study delineated the mutational spectrum of recurrent and/or metastatic SDC. Even in advanced disease, prognostically relevant mutations were identified, emphasizing the clinical importance of cancer genomic profiling tests.

DOI： 10.5604/01.3001.0055.5900

Scopus

PubMed

Language：English  

DOI： 10.5604/01.3001.0055.5235

PubMed

Language：Japanese   Publisher：Otolaryngologia Polska the Polish Otolaryngology  

<b>Introduction:</b> Epicutaneous sensitization (ES) plays a role in the onset of allergic diseases such as atopic dermatitis (AD), bronchial asthma, and food allergies, but its effects on nasal allergic diseases remain unclear. <br><br><b>Aim:</b> The aim of this study was to compare the effects of intranasal challenge following ES with those following intranasal sensitization (NS) on nasal allergic inflammation. <br><br><b>Materials and methods:</b> Female BALB/c mice were sensitized epicutaneously or intranasally with 25 μg of ovalbumin (OVA) and 2 μg of cholera toxin (CT) six times at weekly intervals. These groups were compared with control groups that received ES with phosphate- buffered saline (PBS) alone, OVA alone, or CT alone. Two weeks after the final sensitization, the mice were challenged intranasally with 500 μg of OVA ten times over a two-week period. Four weeks after the final sensitization, allergic inflammation in the nasal cavity, OVA-specific IgE production, and cytokine profiles were evaluated in the different groups. <br><br><b>Results:</b> Post-challenge, there was no significant difference in the number of eosinophils or the thickness of lateral nasal mucosa between the ES and NS groups. However, the serum level of OVA-specific IgE in the ES group was significantly higher than that in the control and NS groups. Levels of IL-4, IL-5, IL-13, and IL-33 in CD4+ T cells were also significantly higher in the ES group than in the NS group. <br><br><b>Conclusions:</b> These results indicate that intranasal challenge following ES induces comparable eosinophilic inflammation in the nasal cavity, but elicits a stronger systemic Th2-type inflammatory response than that following NS.

DOI： 10.5604/01.3001.0055.5830

Scopus

PubMed

Language：Japanese   Publisher：Japanese Society of Otorhinolaryngology-Head and Neck Surgery  

<p>　　Paragangliomas arising from the airway are extremely rare. Herein, we report a patient with paraganglioma who presented with massive airway bleeding. The patient was a 59-year-old man who was transported to our hospital due to sudden-onset hemoptysis. Contrast-enhanced computed tomography revealed a highly vascularized tumor originating from the left posterior side of the tracheal wall. On admission, the patient had neither active hemoptysis nor significant hypertension. However, on the fourth day of hospitalization, he developed severe hemoptysis, necessitating emergency tracheostomy at the bedside. Subsequently, tumor resection with an adequate safety margin was carried out under general anesthesia. Postoperative histopathological examination confirmed the diagnosis of a paraganglioma with negative surgical margins. The tumor was classified as intermediate risk according to the Grading System for Adrenal Pheochromocytoma and Paraganglioma (GAPP). The tracheostoma was closed through a staged reconstructive procedure four months after the initial operation. At the one-year follow-up, there was no evidence of tumor recurrence. Given the long-term recurrence risk associated with paragangliomas, follow-up for at least 10 years is recommended. We plan to continue periodical surveillance of this patient.</p>

DOI： 10.3950/jibiinkotokeibu.128.12_1325

CiNii Research

Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

パラガングリオーマ(PGL)は傍神経節から発生する神経内分泌腫瘍である.気道にて発見される症例はまれだが,血流が豊富な腫瘍であることから出血しやすく,適切な気道確保が行われない場合は死に至る可能性がある.われわれは,大量喀血を来したものの緊急気管切開により救命することのできた,声門下に発見されたPGLの1症例を経験した.気管切開後の腫瘍摘出術では腫瘍周囲に安全域を確保し,気管の窓状切除を行った.摘出術時に形成した気管皮膚瘻は,鼻中隔軟骨を遠位端に埋め込んだDP皮弁を用いて段階的に閉鎖した.過去の報告もあわせて,気道に発生したPGLについて報告する.(著者抄録)

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：Japanese  

Language：English