Updated on 2024/01/09

写真a

 
KATSUYAMA Midori
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Health Research Course Social and Behavior Medicine Assistant Professor
Title
Assistant Professor

Degree

  • 博士(医学) ( 2017.3   金沢大学 )

  • 修士(医科学) ( 2013.3   金沢大学 )

Research History

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Health Research Course Social and Behavior Medicine   Assistant Professor

    2020.7

Committee Memberships

  •   医学科成績集計委員  

    2021.6   

 

Papers

  • Katsuyama M., Miyamoto M., Higo E., Nakamae T., Onitsuka D., Fukumoto A., Yatsushiro M., Hayashi T. .  Development of prevention strategies against bath-related deaths based on epidemiological surveys of inquest records in Kagoshima Prefecture .  Scientific Reports13 ( 1 ) 2277   2023.2Reviewed International journal

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    Authorship:Lead author   Language:English   Publisher:Scientific Reports  

    Sudden death in the bathroom (bath-related death) occurs more frequently in Japan than in other countries. To clarify the epidemiological characteristics of bath-related deaths, we reviewed inquest records of deaths in Kagoshima Prefecture from 2006 to 2019. We identified 2689 cases of bath-related death. Of these cases, 90% were among people aged ≥ 65 years. The majority occurred in a home bathtub between 16:00 and 20:00. Most deaths (52.0%) occurred in winter (December–February), and there were extremely strong negative correlations with the environmental temperatures (maximum, minimum, and mean) on the day of death. We identified the environmental temperature during cold winter months that bath-related deaths are likely to occur in Kagoshima, although further investigation concerning the effects of other confounding factors is required. Forensic autopsies have only been performed in 29 cases and the cause of death was not diagnosed correctly in the majority of cases. Although autopsies are essential to elucidate the pathogenesis of the deaths, it is difficult to increase the rate of autopsies under the current Japanese death investigation system. Therefore, we suggest that the best way to prevent bath-related death is establishing an “Alert system” based on our results, and to have people refrain from bathing on dangerous days.

    DOI: 10.1038/s41598-023-29400-7

    Scopus

    PubMed

    Other Link: https://pubmed.ncbi.nlm.nih.gov/36754968/

  • 勝山 碧 .  Role of Class III Alcohol Dehydrogenase (ADH3) in Renal Pathological Changes Induced by Chronic Alcohol Consumption in Mice .  Journal of Alcoholism & Drug Dependence9   340   2021Role of Class III Alcohol Dehydrogenase (ADH3) in Renal Pathological Changes Induced by Chronic Alcohol Consumption in MiceReviewed

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    Authorship:Lead author   Language:English  

  • Yatsushiro M., Katsuyama M., Nakamae T., Higo E., Miyamoto M., Fukumoto A., Ogata M., Hayashi T. .  Sudden infant death due to mechanical asphyxia caused by a cervical ectopic thymus—An autopsy case .  Forensic Science International: Reports6   2022.12Reviewed

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    Language:English   Publisher:Forensic Science International: Reports  

    The 7-month-old girl was left in a nursery until following morning. About 3 h after being given milk, she was found dead in a right lateral supine position. There was no external evidence of injury to suggest a maltreatment. Hemorrhages were present in the accessory respiratory muscles, but the most notable findings were masses on either side of the trachea and immediately inferior to the thyroid gland. Both of masses were in continuity with the intrathoracic thymus. Histopathologically, the masses showed normal thymic structure and collagen fibers on the left side of the trachea showed metachromasia on Masson's staining. There were no remarkable findings in organs except for congestion. The cause of death was determined to be mechanical asphyxia due to tracheal compression by the cervical ectopic thymus. Hemorrhage in the accessory respiratory muscle was considered to be caused by effortful breathing during the process of asphyxia. The metachromasia of Masson's stain on the trachea may be due to the same mechanism as a “compression mark reaction”, and may be useful in proving compression by the ectopic thymus. We consider that chronic compression of the trachea led to the tracheomalacia, which enabled the final lethal compression when lying in a right lateral supine position. An ectopic thymus is caused by a failure of descent of the embryonic thymic tissue into the thoracic cavity at the appropriate developmental stage and is generally asymptomatic. However, the cervical ectopic thymus should be considered in the diagnosis of a cause of sudden infant death.

    DOI: 10.1016/j.fsir.2022.100286

    Scopus

  • YATSUSHIRO Masahiko, KATSUYAMA Midori, NAKAMAE Takuma, HIGO Eri, MIYAMOTO Machiko, FUKUMOTO Akiko, HAYASHI Takahito .  The method for forensic diagnosis by drowning .  Journal of Japan Driftological Society19 ( 0 ) 1 - 6   2021.12The method for forensic diagnosis by drowningReviewed

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    Language:Japanese   Publisher:Japan Driftological Society  

    DOI: 10.57279/driftological.19.0_1

  • Onitsuka D., Nakamae T., Katsuyama M., Miyamoto M., Higo E., Yatsushiro M., Hayashi T. .  Epidemiological analysis of intramuscular hemorrhage of respiratory and accessory respiratory muscles in fatal drowning cases .  PLoS ONE16 ( 12 December ) e0261348   2021.12Reviewed

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    Language:English   Publisher:PLoS ONE  

    The postmortem diagnosis of drowning death and understanding the mechanisms leading to drowning require a comprehensive judgment based on numerous morphological findings in order to determine the pathogenesis and epidemiological characteristics of the findings. Effortful breathing during the drowning process can result in intramuscular hemorrhage in respiratory and accessory respiratory muscles. However, the characteristics of this phenomenon have not been investigated. We analyzed the epidemiological characteristics of 145 cases diagnosed as drowning, in which hemorrhage, not due to trauma, was found in the respiratory muscles and accessory respiratory muscles. Hemorrhage was observed in 31.7% of these cases, and the incidence did not differ by gender or drowning location. The frequency of hemorrhage was significantly higher in months with a mean temperature below 20°C than in months above 20°C, suggesting a relationship between the occurrence of hemorrhage and low environmental temperature. Moreover, the frequency of hemorrhage was significantly higher in the elderly (aged ≥65 years) compared to those <65 years old. In the elderly, the weakening of muscles due to aging may contribute to the susceptibility for intramuscular hemorrhage. Moreover, these intramuscular hemorrhages do not need to be considered in cases of a potential bleeding tendency due to disease such as cirrhosis or medication such as anticoagulants. Our results indicate that intramuscular hemorrhage in respiratory and accessory respiratory muscles can serve as an additional criterion to differentiate between fatal drowning and other causes of death, as long as no cutaneous or subcutaneous hematomas above the muscles with hemorrhages are observed. In addition, the epidemiological features that such intramuscular hemorrhage is more common in cold environments and in the elderly may provide useful information for the differentiation.

    DOI: 10.1371/journal.pone.0261348

    Scopus

    PubMed

  • Naruo M. Negishi Y. Okuda T. Katsuyama M. Okazaki K. Morita R .  Alcohol consumption induces murine osteoporosis by downregulation of natural killer T-like cell activity .  Immunity, Inflammation and Disease9 ( 4 ) 1 - 13   2021.7Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Immunity, Inflammation and Disease  

    Introduction: Chronic alcohol consumption (CAC) can induce several deleterious effects on the body, including the promotion of osteoporosis; however, the immunological mechanism underlying alcohol-induced osteoporosis is still unclear. Methods: We administered alcohol to mice for 4 weeks as the experimental CAC model and analyzed the bone and immune cells that are located in the vicinity of a bone. Results: IL-4 is known to be a suppressive factor for osteoclastogenesis, and we found that natural killer T (NKT)-like cells, which showed NK1.1-positive, CD3-positive, and α-galactosylceramide-loaded CD1d tetramer-negative, produced IL-4 more effectively than CD4+ T and natural killer (NK) cells. The alcohol consumption facilitated a significant decrease of bone mineral density with the upregulation of nuclear factor of activated T cells 1 and receptor activator of NF-κB ligand expression. Meanwhile, we confirmed that alcohol consumption suppressed the activity of antigen-presenting cells (APCs) and NKT-like cells, leading to decreased IL-4 secretion. Moreover, these harmful effects of alcohol consumption were reduced by simultaneous treatment with a glycolipid antigen OCH. Conclusions: Our results indicate that the inactivation of innate immune cells, APCs, and NKT-like cells are likely to be crucial for alcohol-induced osteoporosis and provide a new therapeutic approach for preventing osteoporosis.

    DOI: 10.1002/iid3.485

    Scopus

    PubMed

  • Midori Katsuyama, Takahisa Okuda, Yoshihiro Sasaki, Masamichi Ishizaki, Kentaro Wada, Motoyo Maruyama, Toshio Akimoto, Youkichi Ohno, Takeshi Haseba .  Role of Class III Alcohol Dehydrogenase (ADH3) in Renal Pathological Changes Induced by Chronic Alcohol Consumption in Mice .  Journal of Alcoholism and Drug Dependence9 ( 4 ) 340   2021.4Role of Class III Alcohol Dehydrogenase (ADH3) in Renal Pathological Changes Induced by Chronic Alcohol Consumption in MiceReviewed

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • 勝山碧, 長谷場健, 石﨑正通, 佐佐木喜広, 丸山基世, 秋元敏雄, 奥田貴久 .  慢性エタノール摂取がマウス腎に及ぼす影響 .  アルコールと医学生物学 アルコール医学の新時代を拓く39   104 - 106   2020.12慢性エタノール摂取がマウス腎に及ぼす影響Reviewed

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    Authorship:Lead author   Publishing type:Research paper (conference, symposium, etc.)  

  • 勝山碧, 長谷場健, 石﨑正通, 佐佐木喜広, 和田健太朗, 丸山基世, 秋元敏雄, 奥田貴久 .  慢性エタノールのマウス腎への影響 .  アルコールと医学生物学 今,アルコール医学研究の重要性を訴える38   37 - 38   2019.12慢性エタノールのマウス腎への影響Reviewed

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    Authorship:Lead author   Publishing type:Research paper (conference, symposium, etc.)  

  • 勝山碧, 長谷場健, 佐佐木喜広, 和田健太朗, 丸山基世, 秋元敏雄, 奥田貴久 .  慢性エタノール摂取マウスにおける腎の形態的変化~1か月摂取での検討~ .  日本腎臓学会誌61 ( 3 ) 412   2019.5慢性エタノール摂取マウスにおける腎の形態的変化~1か月摂取での検討~

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    Language:Japanese   Publishing type:Research paper (international conference proceedings)  

  • 勝山碧, 長谷場健, 佐佐木喜広, 和田健太朗, 丸山基世, 秋元敏雄, 奥田貴久 .  Alcohol Dehydrogenase Class III(ADH3)とアルコール性腎障害の関係の検討 .  アルコールと医学生物学 アルコール関連疾患診療におけるBreak Through37   15 - 16   2019.1Alcohol Dehydrogenase Class III(ADH3)とアルコール性腎障害の関係の検討 Reviewed

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    Language:Japanese   Publishing type:Research paper (conference, symposium, etc.)  

  • Okuda T, Haseba T, Katsuyama M, Maruyama M, Akimoto T, Igarashi T, Ohno Y .  Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice .  Journal of gastroenterology and hepatology33 ( 11 ) 1912 - 1919   2018.11Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in miceReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Midori Katsuyama, Masashi Demura, Hironobu Katsuyama, Hideji Tanii, Kiyofumi Saijoh .  Genistein and menaquinone-4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-E1 cell functions .    16 ( 1 ) 873 - 880   2017.7Genistein and menaquinone-4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-E1 cell functionsReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

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Presentations

  • 伏見 滋子, 濃野 勉, 西松 伸一郎, 片瀬 直樹, 寺田 久美子, 勝山 碧, 出村 昌史, 西條 清史, 長塚 仁, 勝山 博信   骨芽細胞の分化調節におけるWntシグナル伝達機構の関与  

    日本衛生学雑誌  2017.3  (一社)日本衛生学会

  • 勝山 碧, 長谷場 健, 佐佐木 喜広, 和田 健太朗, 丸山 基世, 秋元 敏雄, 奥田 貴久   慢性エタノール摂取マウスにおける腎の形態的変化〜1か月摂取での検討〜  

    第62回日本腎臓学会学術総会  2019.6  (一社)日本腎臓学会

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    Presentation type:Poster presentation  

  • 勝山 碧, 奥田 貴久, 長谷場 健, 石崎 正通, 佐佐木 喜広, 和田 健太朗, 丸山 基世, 秋元 敏雄   慢性エタノール摂取マウスの腎への影響および障害の検討  

    第38回アルコール医学生物学研究会学術集会  2019.1  (株)響文社

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    Presentation type:Oral presentation (general)  

  • 奥田 貴久, 成尾 宗浩, 根岸 靖幸, 勝山 碧, 長谷場 健, 大野 曜吉   慢性アルコール性骨粗鬆症発症についての免疫学的考察  

    第103次日本法医学会学術全国集会  2019.6  (NPO)日本法医学会

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    Presentation type:Poster presentation  

  • 奥田 貴久, 勝山 碧, 長谷場 健, 成尾 宗浩, 根岸 靖幸   多臓器を対象としたアルコール基礎研究の問題点   Invited

    2019年度アルコール薬物依存関連学会合同学術総会  2019.10  (一社)日本アルコール・アディクション医学会

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    Presentation type:Symposium, workshop panel (nominated)  

  • Enzymatic and metabolic adaptation to ethanol by alcohol dehydrogenase 1 and 3 in mice.   International conference

    24th Congress of International Academy of Legal Medicine (IALM)  2018.6 

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    Language:English  

  • 勝山 碧, 長谷場 健, 丸山 基世, 秋元 敏雄, 奥田 貴久   アルコール摂取がマウスの腎臓に及ぼす形態変化と生化学的変動  

    第88回日本法医学会学術集会関東地方集会  2019.10  (NPO)日本法医学会

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    Presentation type:Poster presentation  

  • 勝山碧,中前琢磨,林敬人   アルコール性腎障害におけるAlcohol Dehydrogenase Class III (ADH3)の関与  

    第70回日本法医学会学術集会九州地方集会  2020.9 

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    Presentation type:Oral presentation (general)  

  • 勝山碧,長谷場健,奥田貴久   アルコールがマウス腎に及ぼす影響  

    第39回アルコール医学生物学研究会学術集会  2020.1 

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    Presentation type:Oral presentation (general)  

  • 勝山碧,中前琢磨,林敬人   アルコール性腎障害におけるアルコール脱水素酵素Class I, Class IIIの役割~慢性飲酒時と慢性飲酒下での急性大量飲酒時の病態の差異に注目して~  

    第14回桜ヶ丘地区基礎系研究発表会  2021.3 

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    Presentation type:Oral presentation (general)  

  • 勝山碧, 長谷場健, 石崎正通, 佐佐木喜広, 奥田貴久, 丸山基世, 秋元敏雄, 小黒辰夫, 大野曜吉   アルコール・薬物問題への社会医学的アプローチ Alcohol Dehydrogenaseとアルコール性腎障害の関係を探る   Invited

    第53回日本アルコール・アディクション医学会学術総会  2018.9 

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    Presentation type:Symposium, workshop panel (nominated)  

  • Midori Katsuyama   The roles of Class I and III Alcohol Dehydrogenases (ADHs) in structure of Bowman’s Capsules with Cuboidal Epithelium in male mice   International conference

    19th World Congress of International Society for Biomedical Research on Alcoholism (ISBRA)  2018.9 

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    Language:English   Presentation type:Poster presentation  

  • Naruo M, Negishi Y, Katsuyama M, Haseba T, Okazaki T, Ohno Y, Okuda T   Inactivation of immune cells in alcohol-induced osteopenia.   International conference

    19th Congress of International Society for Biomedical Research on Alcoholism (ISBRA)  2018.9 

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    Language:English   Presentation type:Poster presentation  

  • 勝山碧   ADH1およびADH3とアルコール性腎障害の関係の検討  

    第37回アルコール医学生物学研究会学術集会  2018.1 

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    Presentation type:Oral presentation (general)  

  • Midori Katsuyama   SPINK5 expression in keratinocytes   International conference

    Experimental Biology 2015  2015.3 

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    Language:English   Presentation type:Poster presentation  

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Awards

  • 優秀プレゼンテーション賞

    2021.3   第14回桜ヶ丘地区基礎系研究発表会(鹿児島大学)  

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • 日本医科大学医学会奨学賞

    2018.9   日本医科大学医学会  

    奥田貴久

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    Award type:Award from Japanese society, conference, symposium, etc. 

    研究協力者として受賞

Research Projects

  • アルコール脱水素酵素の臓器障害発症への関与

    2019.4 - 2024.3

    日本学術振興会  科学研究費補助金  基盤研究(B)

    奥田貴久、五十嵐 勉 , 根岸 靖幸 , 高成 広起 , 勝山 碧 , 成尾 宗浩

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    Authorship:Coinvestigator(s) 

  • Low Km ADH1およびHigh Km ADH3とアルコール性臓器障害

    2018.4 - 2022.3

    日本学術振興会  科学研究費補助金  若手研究

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    Authorship:Principal investigator 

 

Teaching Experience

  • 個人識別

    2020.6

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    Level:Undergraduate (specialized) 

  • 血液型I, II

    2020.6

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    Level:Undergraduate (specialized) 

  • DNA多型 

    2020.6

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    Level:Undergraduate (specialized)