論文 - 吉村　卓也

Nishihara Kazuhide, Yoshimine Shin-Ichiro, Goto Takahiro, Ishihata Kiyohide, Kume Ken-Ichi, Yoshimura Takuya, Nakamura Norifumi, Arasaki Akira .  Topographic analysis of the maxillary premolars relative to the maxillary sinus and the alveolar bone using cone beam computed tomography. .  Oral Surg Oral Med Oral Pathol Oral Radiol123 ( 5 ) 606 - 612   2017年5月招待 査読

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology  

OBJECTIVE: The purpose of the present study was to elucidate the anatomic characteristics of the maxillary premolars for the planning of dental treatment using cone beam computed tomography (CBCT). STUDY DESIGN: CBCT images were obtained for 150 maxillary premolars in 68 patients. The internal angle formed by the long axis of the maxillary premolars and the long axis of the alveolar bone was evaluated on the cross-sectional images. The vertical relationships between the maxillary premolars and the maxillary sinus were classified into 5 categories. The bone width and internal angle were compared among the images classified into the 5 categories. RESULTS: The internal angle was 25.5 +/- 6.9 degrees at the maxillary first premolars. The incidence of Type I in the maxillary first premolars was 46.7%. In the maxillary second premolars, the incidence of Type I (14.7%) was significantly lower than the total incidence of Types II, III, IV, and V (85.3%). Type I had the significantly largest internal angle (28.0 +/- 7.7 degrees ) among all types for the maxillary first premolars. CONCLUSION: When considering dental treatment in the maxillary premolars, one should observe the inclination of the maxillary premolars to the alveolar bone as well as the position of the inferior wall of the maxillary sinus.

DOI： 10.1016/j.oooo.2017.01.007

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Ishida T. .  A diagnosis system for detecting cervical lymph node metastasis in oral squamous cell carcinoma: Collective consideration of the results of multiple imaging modalities .  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology29 ( 3 ) 210 - 216   2017年5月

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出版者・発行元：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

DOI： 10.1016/j.ajoms.2016.12.007

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Ishida Takayuki, Hijioka Hiroshi, Kume Kenichi, Yoshimura Takuya, Miyawaki Akihiko, Nozoe Etsuro, Suenaga Shigeaki, Indo Hiroko, Majima Hideyuki J., Nakamura Norifumi .  口腔扁平上皮癌における頸部リンパ節転移を検出する診断システム　多種類の画像診断法の結果の集合的検討(A diagnosis system for detecting cervical lymph node metastasis in oral squamous cell carcinoma: Collective consideration of the results of multiple imaging modalities) .  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology29 ( 3 ) 210 - 216   2017年5月

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出版者・発行元：エルゼビア・ジャパン(株)  

口腔扁平上皮癌における術前の頸部リンパ節転移診断の精度を高めるため、CT、MRI、超音波、18F-FDG PET画像検査の結果を統合利用するチャート式診断基準システムを開発し、その臨床有用性について検討した。当院で手術を施行した口腔扁平上皮癌患者106名を組み入れ、治療時期に応じて、I群(2005年10月〜2008年8月、45名)、II群(2008年9月〜2010年3月、29名)、III群(2010年4月〜2012年3月、32名)、に分類した。頸部リンパ節転移の診断においては、I群では上述の各画像診断法を統合した判定はせず、個別に利用していた。II群、III群では各画像診断法の所見を統合した診断基準が適用されており、II群ではCT/MRIと超音波検査の両者ともに陰性の場合に転移陰性、III群ではII群の基準に加えPET/CTのmaximum standardized uptake value(SUVmax)が3.2未満の場合に転移陰性とそれぞれ診断していた。cN0と診断されていたのは67例で、50例では経過観察が適用されそのうち12例(24%)では原発巣の再発を見ずに頸部リンパ節転移を発症した。術後転移率はI、II、III群でそれぞれ33、24、13%と、診断基準システムが新しいほど改善したが、陽性的中率は50、40、33%と悪化していた。

Kibe Toshiro, Koga Takashi, Nishihara Kazuhide, Fuchigami Takao, Yoshimura Takuya, Taguchi Tetsushi, Nakamura Norifumi .  Examination of the early wound healing process under different wound dressing conditions. .  Oral Surg Oral Med Oral Pathol Oral Radiol123 ( 3 ) 310 - 319   2017年3月招待 査読

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology  

OBJECTIVE: Various types of wound-healing dressings have been used to assist in the healing of surgical wounds. We analyzed the wound-healing process in an animal model using different existing wound dressings. STUDY DESIGN: Full-thickness defects were created using a biopsy punch on the backs of 7-week-old rats. The wounded areas were covered with NEOVEIL (polyglycolic acid [PGA]) or TERUDERMIS (collagen sponge [CS]) affixed using a rat jacket. The wound area, neo-epithelium length, and alpha-smooth muscle actin (alpha-SMA) expression were evaluated and compared among the control, PGA, and CS groups. RESULTS: The wound areas in the control group on days 4 and 7 were significantly smaller than those in the PGA and CS groups. The expression of alpha-SMA in granulation tissue peaked on day 4 for all groups. The expression of alpha-SMA in the control group on days 4 and 7 after injury was greater than in the PGA and CS groups. However, there was no significant difference in the expression of alpha-SMA between the PGA and CS groups. CONCLUSIONS: In this study, PGA and CS suppressed wound contracture and reduced expression of alpha-SMA in wound areas. However, PGA and CS did not affect the neo-epithelium length at the wound site.

DOI： 10.1016/j.oooo.2016.10.023

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Yoshimura T, Yamada S, Shima K, Nakamura N and Tanimoto A .  An elastofibromatous lesion at the tip of the sublingual fold. .  Journal of Dentistry & Oral Disorders2 ( 6 ) 1031   2016年8月査読

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Hamada Taiji, Souda Masakazu, Yoshimura Takuya, Sasaguri Shoko, Hatanaka Kazuhito, Tasaki Takashi, Yoshioka Takako, Ohi Yasuyo, Yamada Sohsuke, Tsutsui Masato, Umekita Yoshihisa, Tanimoto Akihide .  Anti-apoptotic effects of PCP4/PEP19 in human breast cancer cell lines: a novel oncotarget. .  Oncotarget5 ( 15 ) 6076 - 6086   2014年8月査読

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The PCP4/PEP19 is a calmodulin-binding anti-apoptotic peptide in neural cells but its potential role in human cancer has largely been unknown. We investigated the expression of PCP4/PEP19 in human breast cancer cell lines MCF-7, SK-BR-3, and MDA-MB-231 cells, and found that estrogen receptor (ER)-positive MCF-7 and ER-negative SK-BR-3 cells expressed PCP4/PEP19. In the MCF-7 cells, cell proliferation was estrogen-dependent, and PCP4/PEP19 expression was induced by estrogen. In both cell lines, PCP4/PEP19 knockdown induced apoptosis and slightly decreased Akt phosphorylation. Knockdown of calcium/calmodulin-dependent protein kinase kinase 1 (CaMKK1), resulting in decreased phospho-Akt(Thr308), enhanced apoptosis in SK-BR-3 but not in MCF-7 cells. CaMKK2 knockdown moderately decreased phospho-Akt(Thr308) and increased apoptosis in MCF-7 cells but not in SK-BR-3 cells. These data indicated that PCP4/PEP19 regulates apoptosis but exact mechanism is still unknown. PCP4/PEP19 can therefore potentially serve as independent oncotarget for therapy of PCP4/PEP19-positive breast cancers irrespective of ER expression.

DOI： 10.18632/oncotarget.2161

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