研究者詳細 - 吉村　卓也

論文 - 吉村　卓也

分割表示 26 件中 1 - 20 件目／全件表示 >>

Takuya Yoshimura, Yuka Hirano, Taiji Hamada, Seiya Yokoyama, Hajime Suzuki, Hirotaka Takayam, Hirono Migita, Takayuki Ishida, Yasunori Nakamura, Masahiro Ohsawa, Akihiro Asakawa, Kiyohide Ishihata, Akihide Tanimoto. . Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M. . Cancers16 ( 6 ) 1187 2024年3月査読

Hirotaka Takayama, Takuya Yoshimura, Hajime Suzuki, Yuka Hirano, Masahiro Tezuka, Takayuki Ishida, Kiyohide Ishihata, Marie Amitani, Haruka Amitani, Yasunori Nakamura, Yasushi Imamura, Akio Inui, Norifumi Nakamura . Comparison between single-muscle evaluation and cross-sectional area muscle evaluation for predicting the prognosis in patients with oral squamous cell carcinoma: a retrospective cohort study. . Frontiers in Oncology14 2024年5月査読

Takuya Yoshimura, Hajime Suzuki, Hirotaka Takayama, Shotaro Higashi, Yuka Hirano, Masahiro Tezuka, Takayuki Ishida, Kiyohide Ishihata, Marie Amitani, Haruka Amitani, Yasuhiro Nishi, Yasunori Nakamura, Yasushi Imamura, Etsuro Nozoe, Norifumi Nakamura. . Prognostic value of inflammatory biomarkers in aged patients with oral squamous cell carcinoma. . Frontiers in Pharmacology13 2022年11月査読

Yoshimura T, et al. . PCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland . Cancers14 ( 1 ) 2021年12月査読

Takuya Yoshimura, Hajime Suzuki, Hirotaka Takayama, Shotaro Higashi, Yuka Hirano, Masahiro Tezuka, Takayuki Ishida, Kiyohide Ishihata, Marie Amitani, Haruka Amitani, Yasuhiro Nishi, Yasunori Nakamura, Yasushi Imamura, Etsuro Nozoe, Norifumi Nakamura. . Prognostic Role of Preoperative Sarcopenia Evaluation of Cervical Muscles with Long-Term Outcomes of Patients with Oral Squamous Cell Carcinoma . Cancers13 ( 18 ) 2021年9月査読

2. 吉村卓也、鈴木甫、高山大生、東翔太朗、平野憂花、手塚征宏、石田喬之、中村康典、野添悦郎、中村典史 . 口腔扁平上皮癌患者の予後に対する術前低予後栄養指数および高筋肉内脂肪含有量の影響． . 日本口腔外科学会雑67 ( 6 ) 410 - 416 2021年6月査読

Takuya Yoshimura, Hajime Suzuki, Hirotaka Takayama, Shotaro Higashi, Yuka Hirano, Masahiro Tezuka, Takayuki Ishida, Kiyohide Ishihata, Yasuhiro Nishi, Yasunori Nakamura, Yasushi Imamura, Etsuro Nozoe, Norifumi Nakamura . Impact of preoperative low prognostic nutritional index and high intramuscular adipose tissue content on outcomes of patients with oral squamous cell carcinoma . 12 ( 11 ) 3167 2020年10月査読国際誌

PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells . 100 ( 12 ) 1551 - 1563 2020年7月査読国際誌

Yoshimura T. . Cystadenocarcinoma of the minor salivary gland arising in the upper lip: A surgical case of an inadequate cytology specimen hampering conclusive diagnosis . Human Pathology: Case Reports9 64 - 68 2017年9月査読国際誌

Yoshimura Takuya, Hamada Taiji, Hijioka Hiroshi, Souda Masakazu, Hatanaka Kazuhito, Yoshioka Takako, Yamada Sohsuke, Tsutsui Masato, Umekita Yoshihisa, Nakamura Norifumi, Tanimoto Akihide . PCP4/PEP19 promotes migration, invasion and adhesion in human breast cancer MCF-7 and T47D cells. . 7 ( 31 ) 49065 - 49074 2016年8月査読

Ayako Nomura, Takayuki Ishida, Hiroshi Hijioka, Takuya Yoshimura, Hajime Suzuki, Eturo Nozoe, Norifumi Nakamura . The Chart Diagnostic System improves the diagnostic accuracy of cervical lymph node metastasis in oral squamous cell carcinoma. . onco 2023年2月査読

2. Marie Amitani, Haruka Amitani, Tetsuhiro Owaki, Takako Monuki, Satomi Adachi, Suguru Kawazu, Takamasa Fukumoto, Hajime Suzuki, Takuya Yoshimura, Kimiko Mizuma, Yuko Nishida, Hiroko Watanabe, Masayuki Hirose, Kouta Funakoshi, Keiko Ota, Kenta Murotani and Akihiro Asakawa. . The effect of mindfulness yoga in children with school refusal: a study protocol for an exploratory, cluster-randomized, open, standard care-controlled, multicenter clinical trial. . Front Public Health. 2022年7月査読

Megumi Tajitsu, Kiyohide Ishihata, Masahiro Tezuka, Takuya Yoshimura, Misaki Ichiki, Hiromi Ohta, Kanji Nohara, Norifumi Nakamura . Effectiveness of fibreoptic endoscopic evaluation of swallowing and dietary intervention during home-visit dental care in older individuals . Gerodontology 2021年7月査読

In vivo degradation and bone formation behaviors of hydroxyapatite-coated Mg alloys in rat femur . Materials Science and Engineering C122 111942 2021年3月査読

1. Fuchigami T, Suzuki H, Yoshimura T, Kibe T, Chairani E, Kiyono T, Kishida M, Kishida S, Nakamura N. . Ameloblastoma cell lines derived from different subtypes demonstrate distinct developmental patterns in a novel animal experimental model. . Journal of Applied Oral Science 2020年4月査読

Kazuhide Matsunaga, Hirohisa Kusuhara, Akifumi Enomoto, Testuji Nagata, Takuya Yoshimura, Akinori Takeshita, Noritaka Isogai, Suguru Hamada, Norifumi Nakamura, Narikazu Uzawa . Swallowing function before and after subtotal glossectomy and reconstruction with a rectus abdominis musculocutaneous flap. . Surgical Science 2019年査読

1. Dwi Ariawan, Iwan Tofani, Harun Asjiq Gunawan, Muhammad Syafrudin Hak, Ariadna A.Djais, Agoeng Tjahajani, Aya Maeda-Iino, Shoko Nakagawa, Takuya Yoshimura, Takao Fuchigami, Norifumi Nakamura. . Correlation of Basic Fibroblast Growth Factor expression in palatal mucoperiosteal tissue with maxillary growth in operated cleft palate patients. . Journal of International Dental and Medical Research 2019年査読

Honjo Kie, Hamada Taiji, Yoshimura Takuya, Yokoyama Seiya, Yamada Sohsuke, Tan Yan-Qin, Leung Lai K, Nakamura Norifumi, Ohi Yasuyo, Higashi Michiyo, Tanimoto Akihide . PCP4/PEP19 upregulates aromatase gene expression via CYP19A1 promoter I.1 in human breast cancer SK-BR-3 cells. . Oncotarget9 ( 51 ) 29619 - 29633 2018年7月招待査読

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oncotarget

The Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is a novel breast cancer cell expressing peptide, originally found in the neural cells as an anti-apoptotic factor, could inhibit cell apoptosis and enhance cell migration and invasion in human breast cancer cell lines. The expression of PCP4/PEP19 is induced by estrogens in estrogen receptor-positive (ER(+)) MCF-7 cells but also highly expressed in ER(-) SK-BR-3 cells. In this study, we investigated the effects of PCP4/PEP19 on aromatase gene expression in MCF-7 and SK-BR-3 human breast cancer cells. In SK-BR-3 cells but not in MCF-7 cells, PCP4/PEP19 knockdown by siRNA silencing decreased the aromatase expression in gene transcriptional level. When PCP4/PEP19 was overexpressed by CMV promoter-driven PCP4/PEP19 expressing plasmid transfection, aromatase gene transcription increased in SK-BR-3 cells. This aromatase gene transcription is mainly mediated through promoter region PI.1, which is usually active in the placental tissue but not in the breast cancer tissue. These results indicate a new function of PCP4/PEP19 that would enhance aromatase gene upregulation to supply estrogens in heterogeneous cancer microenvironment.

DOI： 10.18632/oncotarget.25651,

Scopus

PubMed

Honjo Kie, Hiraki Tsubasa, Higashi Michiyo, Noguchi Hirotsugu, Nomoto Mitsuharu, Yoshimura Takuya, Batra Surinder K, Yonezawa Suguru, Semba Ichiro, Nakamura Norifumi, Tanimoto Akihide, Yamada Sohsuke . Immunohistochemical expression profiles of mucin antigens in salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative expression predicts a shortened survival in the early postoperative phase. . Histol Histopathol33 ( 2 ) 201 - 213 2018年2月招待査読

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Histology and Histopathology

In mucoepidermoid carcinoma (MEC), the most common salivary gland carcinoma, there is a lack of novel prognostic markers, but post-operative early recurrence strongly affects the clinical course and a poor outcome. It is critical to predict which MEC patients are prone to develop recurrence/metastases. Mucins play pivotal roles in influencing cancer biology, thus affecting cell differentiation, adhesion, carcinoma invasion, aggressiveness and/or metastatic potential. Our aim is to elucidate the significance of expression profiles for mucins, particularly MUC4 and MUC6, and their correlations with various clinicopathological features and recurrence in salivary gland MECs. We performed immunohistochemical analyses on patients with surgically resected primary MEC using antibodies against mucin core proteins MUC4/8G7 and MUC6/CLH5 in 73 paraffin-embedded samples. Recurrence was noted in 15 of 73 (20.5%) patients. MUC4 or MUC6 expression was considered to be negative when <30% or 0% of the MEC cells showed positive staining, respectively. MUC4- and/or MUC6-negative expression respectively and variably showed a significant relationship to pathological tumor high-grade, the presence of lymphovascular invasion, lymph node metastasis and/or tumor-related death. In addition, MUC4 showed significantly negative co-expression with MUC6. Kaplan-Meier analyses revealed that not only single MUC4/6-negative expression but also the combination of both predicted significantly shorter disease-free and disease-specific survivals in MECs, especially within the first two years postoperatively. Therefore, each mucin plays a pivotal role in the pathogenesis of MEC progression. The detection of MUC4 and/or MUC6 might be a powerful parameter in the clinical management of MECs in the early postsurgical phase.

DOI： 10.14670/HH-11-913

Scopus

PubMed

Ishihata Kiyohide, Kakihana Yasuyuki, Yoshimura Takuya, Murakami Juri, Toyodome Soichiro, Hijioka Hiroshi, Nozoe Etsuro, Nakamura Norifumi . Assessment of postoperative complications using E-PASS and APACHE II in patients undergoing oral and maxillofacial surgery. . Patient Saf Surg12 ( 1 ) 3 - 3 2018年査読国際誌

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Patient Safety in Surgery

Background: The prediction of postoperative complications is important for oral and maxillofacial surgeons. We herein aimed to evaluate the efficacy of the Estimation of Physiologic Ability and Surgical Stress (E-PASS) and Acute Physiology, Age, and Chronic Health Evaluation (APACHE) II scoring systems to predict postoperative complications in patients undergoing oral and maxillofacial surgery. Methods: Thirty patients (22 males, 8 females; mean age: 65.1 +/- 12.9 years) who underwent major oral surgeries and stayed in the intensive care unit for postoperative management were enrolled in this study. Postoperative complications were discriminated according to the necessity of the therapeutic intervention by the Medical Department, i.e. according to the Clavien-Dingo classification. E-PASS and APACHE II scores as well as laboratory test values were compared between patients with/without postoperative complications. Results: Postoperative complications were developed in seven patients. The comprehensive risk score (CRS: 1.13 +/- 0.24) and APACHE II score (13.0 +/- 2.58) were significantly higher in patients with postoperative complications than in those without ones (p < 0.01, p < 0.05, respectively). The CRS showed an appropriate discriminatory power for predicting postoperative complications (area under the curve: 0.814). Furthermore, a correlation was detected between APACHE II scores and postoperative data until C-reactive protein levels decreased to < 1.0 mg/L (r = 0.43, p < 0.05). Conclusion: The E-PASS and APACHE II scoring systems were both shown to be useful to predict postoperative complications after oral and maxillofacial surgery.

DOI： 10.1186/s13037-018-0152-6,

Scopus

PubMed

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論文 - 吉村　卓也