Updated on 2024/10/04

写真a

 
KASHIWADANI Hideki
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Functional Biology and Pharmacology Lecturer
Title
Lecturer

Degree

  • Ph.D. ( 2000.10   Osaka University )

Research Interests

  • itch

  • pain

  • odor

  • behavioral neuroscience

  • electrophysiology

  • central autonomic system

  • central olfactory system

  • 学習

  • 大脳嗅皮質

  • olfaction

  • olfactory cortex

  • olfactory bulb

  • 嗅上反

  • 味覚

  • 匂い地図

  • anterior olfactory nucleus

  • optical recording

  • mitral cell

  • シナプス伝達

  • orexin

  • アセチルコリン

  • odor information

  • odor map

  • におい分子カテゴリープロフィール

  • synchronization

  • olfactory

  • mitral cell

  • memory

  • electrophysiology

  • Cortex

  • insular cortex

  • slow wave sleep

  • sensory gating

  • 樹状突起間抑制性シナプス

  • sleep-awake

  • 行動状態

  • Analgesia

  • electrophysiology

  • 食物のにおい

  • anxiolytic

  • depression

  • itch

  • menopause

  • irritability

  • anxiety

  • PMDD

Research Areas

  • Life Science / Basic brain sciences  / 感覚生理学

  • Life Science / Clinical pharmacy

  • Life Science / Animal physiological chemistry, physiology and behavioral biology

  • Life Science / Physiology

  • Life Science / Neuroscience-general

  • Life Science / Neuroscience-general

  • Life Science / Pathophysiologic neuroscience

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Research History

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course   Lecturer

    2012.4

  • The University of Tokyo   Assistant Professor

    2002.7 - 2012.3

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    Country：Japan

  • Tokyo Women's Medical University   Research Assistant

    2000.4 - 2002.6

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    Country：Japan

  • RIKEN   Brain Science Institute   Researcher

    1997.4 - 2000.3

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    Country：Japan

  • Grad Sch Med Dental Sci, Kagoshima Univ   Dept Physiol   Senior Assistant Professor

    2012.4

Professional Memberships

  • 日本生理学会

    2015.10

  • 北米神経科学学会

    2015.10

  • 日本神経科学学会

    2015.10

  • 日本神経科学学会

  • 日本生理学会

  • Society for Neuroscience

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Papers

  • Kaneko T., Kuwaki T., Kashiwadani H. .  Hypothalamic orexinergic neurons modulate pain and itch in an opposite way: pain relief and itch exacerbation .  Journal of Physiological Sciences72 ( 1 ) 21   2022.12Reviewed International journal

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Physiological Sciences  

    Pain and itch are recognized as antagonistic sensations; pain suppresses itch and inhibition of pain generates itch. There is still a lack of evidence about the neural mechanism of the interaction between pain and itch in the central nervous system. In this study, we focused on the orexin (ORX) neurons in the lateral hypothalamus (LH), which mediate various “defense responses” when animals confront stressors. We found that the scratching behaviors induced by the pruritogen were significantly suppressed in ORX-neuron-ablated (ORX-abl) mice. The exaggerated pain behavior and attenuated itch behavior observed in ORX-abl mice indicated that ORX neurons modulate pain and itch in an opposite way, i.e., pain relief and itch exacerbation. In addition, most of the ORX neurons responded to both pain and itch input. Our results suggest that ORX neurons inversely regulate pain- and itch-related behaviors, which could be understood as a defense response to cope with stress environment.

    DOI： 10.1186/s12576-022-00846-0

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  • Sachiko Koyama, Kenji Kondo, Rumi Ueha, Hideki Kashiwadani, Thomas Heinbockel .  Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia. .  International journal of molecular sciences22 ( 16 )   2021.8Reviewed International coauthorship International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms of the SARS-CoV-2 disease, COVID-19, is the loss of chemical senses, i.e., smell and taste. Smell training is one of the methods used in facilitating recovery of the olfactory sense, and it uses essential oils of lemon, rose, clove, and eucalyptus. These essential oils were not selected based on their chemical constituents. Although scientific studies have shown that they improve recovery, there may be better combinations for facilitating recovery. Many phytochemicals have bioactive properties with anti-inflammatory and anti-viral effects. In this review, we describe the chemical compounds with anti- inflammatory and anti-viral effects, and we list the plants that contain these chemical compounds. We expand the review from terpenes to the less volatile flavonoids in order to propose a combination of essential oils and diets that can be used to develop a new taste training method, as there has been no taste training so far. Finally, we discuss the possible use of these in clinical settings.

    DOI： 10.3390/ijms22168912

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  • Yurina Higa, Hideki Kashiwadani, Mitsutaka Sugimura, Tomoyuki Kuwaki .  Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice. .  Scientific reports11 ( 1 ) 9224 - 9224   2021.4Reviewed International journal

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Linalool odor exposure induces an analgesic effect in mice. This effect disappeared in the anosmic model mice, indicating that olfactory input evoked by linalool odor triggered this effect. Furthermore, hypothalamic orexinergic neurons play a pivotal role in this effect. However, the neuronal circuit mechanisms underlying this effect have not been fully addressed. In this study, we focused on the descending orexinergic projection to the spinal cord and examined whether this pathway contributes to the effect. We assessed the effect of intrathecal administration of orexin receptor antagonists on linalool odor-induced analgesia in the tail capsaicin test. We found that the selective orexin type 1 receptor antagonist, but not the selective orexin type 2 receptor antagonist, prevented the odor-induced analgesic effect. Furthermore, immunohistochemical analyses of c-Fos expression induced by the capsaicin test revealed that neuronal activity of spinal cord neurons was suppressed by linalool odor exposure, which was prevented by intrathecal administration of the orexin 1 receptor antagonist. These results indicate that linalool odor exposure drives the orexinergic descending pathway and suppresses nociceptive information flow at the spinal level.

    DOI： 10.1038/s41598-021-88359-5

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  • Hiroki Harada, Hideki Kashiwadani, Yuichi Kanmura, Tomoyuki Kuwaki .  Linalool odor-induced anxiolytic effects in mice. .  Front Behav Neurosci12   241   2018.10Reviewed International journal

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fnbeh.2018.00241

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  • Tashiro S, Yamaguchi R, Ishikawa S, Sakurai T, Kajiya K, Kanmura Y, Kuwaki T, Kashiwadani H .  Odour-induced analgesia mediated by hypothalamic orexin neurons in mice .  Scientific Reports6   37129   2016.11Odour-induced analgesia mediated by hypothalamic orexin neurons in miceReviewed International journal

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep37129

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  • Kikuta, S., Sato, K., Kashiawdani, H., Tsunoda, K., Yamasoba, T., and Mori, K .  Neurons in the anterior olfactory nucleus pars externa detect right or left localization of odor sources .  Proceedings of the National Academy of Sciences of the United States of America107   12363 - 12368   2010.7Neurons in the anterior olfactory nucleus pars externa detect right or left localization of odor sourcesReviewed International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Kikuta, S., Kashiawdani, H., and Mori, K .  Compensatory rapid switching of binasal inputs in the olfactory cortex .  Journal of Neuroscience28   11989 - 11997   2008.11Compensatory rapid switching of binasal inputs in the olfactory cortexReviewed International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Murakami, M., Kashiawdani, H., Kirino, Y., and Mori, K .  State-dependent sensory gating in olfactory cortex .  Neuron46   285 - 296   2005.4State-dependent sensory gating in olfactory cortexReviewed International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Kashiwadani, H., Sasaki, Y.F., Uchida, N., and Mori, K. .  Synchronized oscillatory discharges of mitral/tufted cells with different molecular receptive ranges in the rabbit olfactory bulb .  Journal of Neurophysiology82   1786 - 1792   1999.10Synchronized oscillatory discharges of mitral/tufted cells with different molecular receptive ranges in the rabbit olfactory bulbReviewed International journal

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  • Kaneko T., Oura A., Imai Y., Kusumoto-Yoshida I., Kanekura T., Okuno H., Kuwaki T., Kashiwadani H. .  Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray .  Communications Biology7 ( 1 ) 290   2024.12

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    Language：Japanese   Publisher：Communications Biology  

    Pain and itch are recognized as antagonistically regulated sensations; pain suppresses itch, whilst pain inhibition enhances itch. The neural mechanisms at the central nervous system (CNS) underlying these pain-itch interactions still need to be explored. Here, we revealed the contrasting role of orexin-producing neurons (ORX neurons) in the lateral hypothalamus (LH), which suppresses pain while enhancing itch neural processing, by applying optogenetics to the acute pruritus and pain model. We also revealed that the circuit of ORX neurons from LH to periaqueductal gray regions served in the contrasting modulation of itch and pain processing using optogenetic terminal inhibition techniques. Additionally, by using an atopic dermatitis model, we confirmed the involvement of ORX neurons in regulating chronic itch processing, which could lead to a novel therapeutic target for persistent pruritus in clinical settings. Our findings provide new insight into the mechanism of antagonistic regulation between pain and itch in the CNS.

    DOI： 10.1038/s42003-024-05997-x

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  • Uchino E., Kusumoto-Yoshida I., Kashiwadani H., Kanmura Y., Matsunaga A., Kuwaki T. .  Identification of hypothermia-inducing neurons in the preoptic area and activation of them by isoflurane anesthesia and central injection of adenosine .  The journal of physiological sciences : JPS74 ( 1 ) 33   2024.6

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    Language：Japanese   Publisher：The journal of physiological sciences : JPS  

    Hibernation and torpor are not passive responses caused by external temperature drops and fasting but are active brain functions that lower body temperature. A population of neurons in the preoptic area was recently identified as such active torpor-regulating neurons. We hypothesized that the other hypothermia-inducing maneuvers would also activate these neurons. To test our hypothesis, we first refined the previous observations, examined the brain regions explicitly activated during the falling phase of body temperature using c-Fos expression, and confirmed the preoptic area. Next, we observed long-lasting hypothermia by reactivating torpor-tagged Gq-expressing neurons using the activity tagging and DREADD systems. Finally, we found that about 40-60% of torpor-tagged neurons were activated by succeeding isoflurane anesthesia and by icv administration of an adenosine A1 agonist. Isoflurane-induced and central adenosine-induced hypothermia is, at least in part, an active process mediated by the torpor-regulating neurons in the preoptic area.

    DOI： 10.1186/s12576-024-00927-2

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  • Kashiwadani H, Higa Y, Sugimura M, Kuwaki T .  Linalool odor-induced analgesia is triggered by TRPA1-independent pathway in mice. .  Behavioral and brain functions : BBF17 ( 1 ) 3 - 3   2021.4Reviewed International journal

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    We had recently reported that linalool odor exposure induced significant analgesic effects in mice and that the effects were disappeared in olfactory-deprived mice in which the olfactory epithelium was damaged, thus indicating that the effects were triggered by chemical senses evoked by linalool odor exposure. However, the peripheral neuronal mechanisms, including linalool receptors that contribute toward triggering the linalool odor-induced analgesia, still remain unexplored. In vitro studies have shown that the transient receptor potential ankyrin 1 (TRPA1) responded to linalool, thus raising the possibility that TRPA1 expressed on the trigeminal nerve terminal detects linalool odor inhaled into the nostril and triggers the analgesic effects. To address this hypothesis, we measured the behavioral pain threshold for noxious mechanical stimulation in TRPA1-deficient mice. In contrast to our expectation, we found a significant increase in the threshold after linalool odor exposure in TRPA1-deficient mice, indicating the analgesic effects of linalool odor even in TRPA1-deficient mice. Furthermore, intranasal application of TRPA1 selective antagonist did not alter the analgesic effect of linalool odor. These results showed that the linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.

    DOI： 10.1186/s12993-021-00176-y

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  • 柏谷英樹 .  リナロール香気の持つ抗不安作用とその脳内機序 .  ファルマシア57 ( 3 ) 204 - 206   2021リナロール香気の持つ抗不安作用とその脳内機序 Invited

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    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Sichong Chen, Nobuaki Takahashi, Changping Chen, Jordan L Pauli, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki .  Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice. .  Frontiers in physiology11   576209 - 576209   2020.10Reviewed International coauthorship International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel that is broadly expressed in sensory pathways, such as the trigeminal and vagus nerves. It is capable of detecting various irritants in inspired gasses and is activated during hypoxia. In this study, the role of TRPA1 in hypoxia-induced behavioral, respiratory, and cardiovascular responses was examined through four lines of experiments using TRPA1 knockout (KO) mice and wild type (WT) littermates. First, KO mice showed significantly attenuated avoidance behavior in response to a low (15%) oxygen environment. Second, the wake-up response to a hypoxic ramp (from 21 to 10% O2 in 40 s) was measured using EEG electrodes. WT mice woke up within 30 s when oxygen was at 13-14%, but KO mice did not wake up until oxygen levels reached 10%. Histological analysis confirmed that mild (13% O2) hypoxia resulted in an attenuation of trigeminal neuronal activation in KO mice. Third, the ventilatory response to hypoxia was measured with whole body plethysmography. KO mice showed attenuated responses to mild hypoxia (15% O2) but not severe hypoxia (10% O2). Similar responses were observed in WT mice treated with the TRPA1 blocker, AP-18. These data clearly show that TRPA1 is necessary for multiple mild hypoxia (13-15% O2)-induced physiological responses. We propose that TRPA1 channels in the sensory pathways innervating the airway can detect hypoxic environments and prevent systemic and/or cellular hypoxia from occurring.

    DOI： 10.3389/fphys.2020.576209

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  • Hideki Kashiwadani, Yuichi Kanmura, Tomoyuki Kuwaki .  Application of calibrated forceps for assessing mechanical nociception with high time resolution in mice .  PLOS ONE12 ( 2 ) e0172461   2017.2Reviewed International journal

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：PUBLIC LIBRARY SCIENCE  

    In order to investigate the basic physiological mechanisms of pain and the anti-nociceptive effects of analgesics, development of pain assays in mice is critical due to the advances of genetic manipulation techniques. The von Frey hairs/Semmes-Weinstein monofilaments test (von Frey test) has long been applied to examine mechanical nociception in mice. Though the von Frey test is a well-established and standardized method, it is inappropriate to assess a rapid change in the nociceptive threshold because voluntary resting/sleeping states are necessary to examine the response. In this study, we assessed the effectiveness of calibrated forceps to determine the mechanical nociceptive threshold in mice. Repeated daily measurements of the threshold over 5 days indicated that the device obtained stable and reliable values. Furthermore, repeated measurements with 5 minute intervals revealed that the device detected the rapid change of the threshold induced by remifentanil, a short-acting mu-receptor agonist. These results indicate that the calibrated forceps are well-suited for measuring the mechanical nociceptive threshold in mice, and are useful in assessing the effects of short-acting analgesics on mechanical nociception.

    DOI： 10.1371/journal.pone.0172461

    Web of Science

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  • Inuki K, Chen C, Pauli JL, Kuroki C, Tashiro S, Kanmura Y, Kashiwadani H, Kuwaki T .  Nasal TRPA1 mediates irritant-induced bradypnea in mice .  Physiological Reports4 ( 24 ) e13098   2016.12Nasal TRPA1 mediates irritant-induced bradypnea in miceReviewed International coauthorship International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.14814/phy2.13098

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  • Ueda H, Suga M, Yagi T, Kusumoto-Yoshida I, Kashiwadani H, Kuwaki T, Miyawaki S .  Vagal afferent activation induces salivation and swallowing-like events in anesthetized rats .  American Journal of Physiology Regulatory, Integrative and Comparative Physiology311 ( 5 ) R964 - R970   2016.10Vagal afferent activation induces salivation and swallowing-like events in anesthetized ratsReviewed International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajpregu.00292.2016

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  • Yonemitsu, T., Kuroko, C., Takahashi, N., Mori, Y., Kanmura, Y., Kashiwadani, H., Ootsuka, Y., Kuwaki, T. .  TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep .  Scientific Report3   3100   2013.10TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleepReviewed International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Matsumoto, H., Kashiawdani, H., Nagao, H., Aiba, A., and Mori, K .  Odor-induced persistent discharge of mitral cells in the mouse olfactory bulb .  Journal of Neurophysiology101   1890 - 1900   2009.4Odor-induced persistent discharge of mitral cells in the mouse olfactory bulbReviewed International journal

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  • Tsuno, Y., Kashiawdani, H., and Mori, K .  Behavioral state regulation of dendrodendritic synaptic inhibition in the olfactory bulb .  Journal of Neuroscience 28   9227 - 9238   2008.9Behavioral state regulation of dendrodendritic synaptic inhibition in the olfactory bulbReviewed International journal

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  • Miyata, M., Kashiwadani, H., Fukaya, M., Hayashi, T., Wu, D., Suzuki, T., Watanabe, M., and Kawakami, Y. .  Role of thalamic phospholipase C・4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain .  Journal of Neuroscience 23   8098 - 8108   2003.9Role of thalamic phospholipase C・4 mediated by metabotropic glutamate receptor type 1 in inflammatory painReviewed International coauthorship International journal

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Hideki Kashiwadani .  Synchronized oscillatory discharges of mitral/tufted cells and olfactory information processing in the MOB .      2000.10Synchronized oscillatory discharges of mitral/tufted cells and olfactory information processing in the MOBReviewed

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    Authorship：Lead author,　Last author,　Corresponding author   Language：English   Publishing type：Doctoral thesis  

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Books

  • Development of Functional Foods for Anti-Fatigue, Anti-Stress, and Improving Sleep Quality

    （ Role： Joint author）

    2020.4 

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    Total pages：287   Language：Japanese Book type：Scholarly book

MISC

  • Editorial: Physiology and pathophysiology of the olfactory system Invited International coauthorship International journal

    Kashiwadani H., Heinbockel T., Imamura F., Yamaguchi M., Koyama S., Kondo K.

    Frontiers in Neural Circuits   16   1025087   2022.10

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：Frontiers in Neural Circuits  

    DOI： 10.3389/fncir.2022.1025087

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  • Central nervous system underlying linalool odor-induced anxiolytic effect Invited

    KASHIWADANI Hideki

    Journal of Japan Association on Odor Environment   52 ( 2 )   112 - 117   2021.3

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：Japan Association on Odor Environment  

    <p>Since ancient times, we have examined the anxiolytic effects of odorous compounds derived from plant extracts. Nowadays, the effects are introduced for the treatment of folk remedy. However, the neuronal mechanisms underlying the odor-induced anxiolytic effects has not fully addressed yet. In this review, the anxiolytic effects of odor of linalool (one of the major odorous compounds in lavender extract) which is triggered by olfactory input via endogenous benzodiazepine-like transmitter in the brain.</p>

    DOI： 10.2171/jao.52.112

  • 【におい・かおりの積極的な利用(Part 1)】リナロール香気が不安を軽減する脳の仕組み Invited

    柏谷 英樹

    におい・かおり環境学会誌   52 ( 2 )   112 - 117   2021.3

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    Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：(公社)におい・かおり環境協会  

    古来より植物の芳香が抗不安効果を持つことは経験的に広く知られてきた。今日でもその作用は民間療法として取り入れられている。しかしながら「香気が抗不安効果を生み出すメカニズム」については未だ不明である。本稿ではリナロール(ラベンダー精油の主要香気成分の一つ)の香気が持つ抗不安作用、その作用の嗅覚依存性、そしてベンゾジアゼピン感受性GABAA受容体の関与を中心に、その基盤となる脳内メカニズムについて最新の知見をもとに解説する。(著者抄録)

  • 【嗅覚研究の進展が拓く新たな薬物療法の可能性】リナロール香気の持つ抗不安作用とその脳内機序 Invited

    柏谷 英樹

    ファルマシア   57 ( 3 )   204 - 206   2021.3

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    Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：(公社)日本薬学会  

  • リナロール香気の持つ抗不安作用とその脳内機序 Invited

    柏谷 英樹

    ファルマシア   57 ( 3 )   204 - 206   2021

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    Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：公益社団法人 日本薬学会  

    リナロール（ラベンダー香気の主要成分の一つ）に香気暴露すると、抗不安効果が生じる。この効果には嗅覚系を介した「匂い」入力、そして内在性ベンゾジアゼピン様物質による神経伝達が必要であることが明らかになった。リナロール香気暴露では鎮静作用や運動抑制作用が見られないため、従来の抗不安薬による薬物療法の補完療法として臨床応用されることが期待されている。

    DOI： 10.14894/faruawpsj.57.3_204

  • マウスにおけるリナロールの匂いに誘発される抗そう痒効果(Linalool odor induced anti-pruritic effects in mice)

    金子 達朗, 桑木 共之, 柏谷 英樹

    医学教育   51 ( Suppl. )   165 - 165   2020.7

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    Publisher：(一社)日本医学教育学会  

  • Analgesic and Anxiolytic Effects of Linalool Odor in Mice

    Hideki KASHIWADANI

    283   45 - 54   2019.9

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：NIPPON KORYO KYOKAI  

  • リナロール誘発性鎮痛の投与経路による違い

    Kashiwadani H

    Aroma Research   75   224 - 225   2018.8

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：フレグラスジャーナル社  

  • 香り・においと疾患　基礎から応用まで　リナロール誘発性鎮痛の投与経路による違い

    柏谷 英樹

    Aroma Research   19 ( 3 )   224 - 225   2018.8

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    Publisher：フレグランスジャーナル社  

  • 香り・においと疾患 基礎から応用まで リナロール誘発性鎮痛の投与経路による違い

    柏谷 英樹

    Aroma Research   19 ( 3 )   224 - 225   2018.8

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    Publisher：フレグランスジャーナル社  

  • リナロール香気に誘発される抗不安効果

    原田 浩輝, 上村 裕一, 桑木 共之, 柏谷 英樹

    日本生理学雑誌   80 ( 2 )   30 - 30   2018.5

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    Publisher：(一社)日本生理学会  

  • Odor-induced analgesia and food-derived odor

    48 ( 5 )   373 - 379   2017.9

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 【食物の香りとその機能性】香気誘発性鎮痛と食品香気

    柏谷 英樹

    におい・かおり環境学会誌   48 ( 5 )   373 - 379   2017.9

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    Publisher：(公社)におい・かおり環境協会  

    香気の中には情動とそれに伴う自律応答を強く惹起するものがあることが経験的に知られており、その作用を医療に応用する試みは古くよりなされてきた。しかしながら「におい」がどのような脳内機序によりその機能を発現するのかは不明であった。我々はマウス疼痛テスト系を用いて香気暴露による鎮痛効果を測定し、テルペン系化合物の一種、リナロールの香気が鎮痛効果を有することを見出した。さらに、この効果は嗅覚系を介して(つまり「におい」として)惹起されること、そして視床下部オレキシン神経の活性化が必須であることを見出した。また、リナロールを多量に含む芋焼酎香気でも、リナロール濃度依存的に鎮痛効果が現れることを明らかにした。本稿ではこれらの知見を中心に紹介する。(著者抄録)

    Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J03864&link_issn=&doc_id=20171012400002&doc_link_id=%2Ffc7nioik%2F2017%2F004805%2F004%2F0373-0379%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffc7nioik%2F2017%2F004805%2F004%2F0373-0379%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 【食物の香りとその機能性】香気誘発性鎮痛と食品香気

    柏谷 英樹

    におい・かおり環境学会誌   48 ( 5 )   373 - 379   2017.9

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    Publisher：(公社)におい・かおり環境協会  

    香気の中には情動とそれに伴う自律応答を強く惹起するものがあることが経験的に知られており、その作用を医療に応用する試みは古くよりなされてきた。しかしながら「におい」がどのような脳内機序によりその機能を発現するのかは不明であった。我々はマウス疼痛テスト系を用いて香気暴露による鎮痛効果を測定し、テルペン系化合物の一種、リナロールの香気が鎮痛効果を有することを見出した。さらに、この効果は嗅覚系を介して(つまり「におい」として)惹起されること、そして視床下部オレキシン神経の活性化が必須であることを見出した。また、リナロールを多量に含む芋焼酎香気でも、リナロール濃度依存的に鎮痛効果が現れることを明らかにした。本稿ではこれらの知見を中心に紹介する。(著者抄録)

  • 機械性疼痛に対するOdorant-X香気誘発性鎮痛の効果

    井上 恵理, 田代 章悟, 山口 蘭, 上村 裕一, 桑木 共之, 柏谷 英樹

    日本生理学雑誌   79 ( 1 )   33 - 33   2017.2

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    Publisher：(一社)日本生理学会  

  • 唾液分泌と嚥下の調節機構における内臓感覚の役割

    植田 紘貴, 菅 真有, 八木 孝和, 楠本 郁恵, 柏谷 英樹, 桑木 共之, 宮脇 正一

    日本生理学雑誌   79 ( 1 )   26 - 26   2017.2

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    Publisher：(一社)日本生理学会  

  • 芋焼酎香気による鎮痛作用と匂い誘発性鎮痛

    Kashiwadani H

    Aroma Research   17 ( 3 )   36 - 40   2016.11

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • ゾーン構造 Reviewed

    柏谷英樹

    脳科学辞典   DOI：10.14931/bsd.1986   2012.9

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 嗅覚系における感覚ゲーティング機構と匂い情報処理

    柏谷英樹、森憲作

    実験医学増刊   24 ( 15 )   2236 - 2242   2006.12

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations

  • Kaneko Tatsuroh, Kuwaki Tomoyuki, Kashiwadani Hideki   視床下部オレキシン作動性ニューロンは痛みと痒みを逆調節する　痛みの緩和と痒みの増悪(Hypothalamic orexinergic neurons inversely regulate pain and itch: pain relief and itch exacerbation)   International conference

    The Journal of Physiological Sciences  2022.12  (一社)日本生理学会

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    Language：English   Presentation type：Symposium, workshop panel (public)  

  • 倉本恵梨子、柏谷英樹、岩井治樹、山中淳之、後藤哲哉   頭頸部の侵害性感覚受容に関わるマウス三叉神経系について、アデノ随伴ウイルスベクターを用いた研究   International conference

    第128回日本解剖学会全国学術総会  2023.3  日本解剖学会

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    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：仙台   Country：Japan  

  • Kaneko, T., Kuwaki, T., Kashiwadani H.   Hypothalamic orexinergic neurons modulate pain and itch in an opposite way: pain relief and itch exacerbation   Invited International conference

    100th Japan Physiological Society Meeting  2023.3  Japan Physiological Society

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    Event date： 2023.3

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Kyoto   Country：Japan  

  • Hideki KASHIWADANI, Sho UENO, Tomoyuki KUWAKI   Chronic activation of hypothalamic orexin neurons in menopause model mice   International conference

    100th Japan Physiological Society Meeting  2023.3  Japan Physiological Society

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    Event date： 2023.3

    Language：English  

    Venue：Kyoto   Country：Japan  

  • マークル遥、桑木共之　柏谷英樹   ゲラニオール香気による月経前症候群の抑うつ緩和  

    第73回西日本生理学会  2022.10  西日本生理学会

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    Event date： 2022.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：長崎   Country：Japan  

  • Kashiwadani H.1, Higa Y.1,2, Sugimura M.2, Kuwaki T.1   TRPA1-independent pathway triggers linalool odor-induced analgesia in mice   International conference

    44th Annual Meeting of the Japan Neuroscience Society  2021.7  Japan Neuroscience Society

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    Event date： 2021.7

    Language：English   Presentation type：Poster presentation  

    Venue：Kobe   Country：Japan  

  • Li M, Kuwaki T, Kashiwadani H   Orexinergic transmission suppresses the anxiolytic effects of linalool odor in mice  

    第47回　自律神経生理研究会 

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    Event date： 2019.12

    Language：English   Presentation type：Oral presentation (general)  

    Venue：東京・新宿  

  • Higa Y, Sugimura M, Kuwaki T, Kashiwadani H   Descending orexinergic inhibitin via orexin-1 receptors in spinal cord contributes to linalool odor-induced analgesia in mice   International conference

    The 42nd Annual Meeting of the Japan Neuroscience Society  The Japan Neuroscience Society

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    Event date： 2019.7

    Language：English   Presentation type：Poster presentation  

    Venue：Niigata  

  • Hiroki Harada, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani   Linalool Exposure SHowed Anxiolytic-like Effects in Mice   International conference

    ASA 2018: American Society of Anesthesiologists Annual Meeting  American Society of Anesthesiologists

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    Event date： 2018.10

    Language：English   Presentation type：Poster presentation  

    Venue：San Francisco  

  • Yurina Higa, Mitsutaka Sugimura, Tomoyuki Kuwaki, Hideki Kashiwadani   Duration of linalool odor-induced analgesia in mice   International conference

    15th International Dental Congress on Anesthesia, Sedation and Pain Control  International Federation of Dental Anesthesia Society

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    Event date： 2018.10

    Language：English   Presentation type：Poster presentation  

    Venue：Nara  

  • Yurina Higa, Mitsutaka Sugimura, Tomoyuki Kuwaki, Hideki Kashiwadani   Duration of action of linalool odor-induced analgesia  

    11th Kagoshima Neuroscience Meeting 

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    Event date： 2018.6

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Ibusuki  

  • Neural circuit mechanisms of odor-guided emotional and motivated behaviors  

    The 95th Annual Meeting of the Physiological Society of Japan 

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    Event date： 2018.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：Takamatsu  

  • Hideki KASHIWADANI   Odor-induced analgesia in mice   Invited International conference

    第16回国際シンポジウム「味覚嗅覚の分子神経機構」  Kyushu University, Research and Development Center for Taste and Odor Sensing

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    Event date： 2017.11

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：福岡  

  • 柏谷英樹, 原田浩輝, 上村裕一, 桑木共之   リナロール香気に誘発される抗不安効果  

    第68回西日本生理学会 

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    Event date： 2017.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡  

  • 柏谷英樹   香気誘発性鎮痛と芋焼酎香気   Invited

    第43回日本応用糖質科学会九州支部講演会 

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    Event date： 2017.9

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：鹿児島  

  • Ueda H, Suga M, Yagi T, Kusumoto-Yoshida I, Kashiwadani H, Kuwaki T, Miyawaki S   Salivation and swallowing-like events are induced by vagal afferent activation in anesthetized rats  

    94th Annual Meeting of the Physiological Society of Japan 

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    Event date： 2017.3

    Language：English   Presentation type：Poster presentation  

    Venue：Hamamatsu  

  • Harada H, Kanmura Y, Kuwaki T, Kashiwadani H   Odorant-X exposure showed anxiolytic effects in mice  

    94th Annual Meeting of the Physiological Society of Japan 

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    Event date： 2017.3

    Language：English   Presentation type：Poster presentation  

    Venue：Hamamatsu  

  • Inoue E, Kuwaki K, Kashiwadani H   Application of calibrated forceps for evaluating antinociceptive effect induced by shortacting analgesic in mice   International conference

    46th annual meeting of Society for Neuroscience 

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    Event date： 2016.11

    Language：English   Presentation type：Poster presentation  

    Venue：San Diego  

  • 植田紘貴、菅真有、八木孝和、楠本郁恵、柏谷英樹、桑木共之、宮脇正一   唾液分泌と嚥下の調節機構における内臓感覚の役割  

    第67回西日本生理学会 

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    Event date： 2016.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：鹿児島  

  • 井上恵理、田代章悟、山口蘭、上村裕一、桑木共之、柏谷英樹   機械性疼痛に対するOdorant-X香気誘発性鎮痛の効果  

    第67回西日本生理学会 

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    Event date： 2016.10

    Language：English   Presentation type：Poster presentation  

    Venue：鹿児島  

  • Inoue E, Kanmura Y, Kuwaki K, Kashiwadani H   The endogenous opioid system mediates odorant-X-induced analgesia in mice  

    93rd Annual Meeting of the Physiological Society of Japan 

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    Event date： 2016.3

    Language：English   Presentation type：Poster presentation  

    Venue：Sapporo  

  • 井上恵理、上村裕一、加治屋勝子、桑木共之、柏谷英樹   香気誘発性鎮痛におけるオピオイド受容体の関与  

    第43回自律神経生理研究会 

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    Event date： 2015.12

    Language：Japanese   Presentation type：Oral presentation (general)  

  • Sodemi Ishikawa, Tomoyuki Kuwaki, Hideki Kashiwadani   Central neuronal circuit underlying odor-induced analgesia in mice   International conference

    the 45th annual meeting of Society for Neuroscience 

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    Event date： 2015.10

    Language：English   Presentation type：Poster presentation  

    Venue：Chicago  

  • Ran Yamaguchi, Sodemi Ishikawa, Shogo Tashiro, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani   The effect of short odor exposure in odorant-X induced analgesia  

    the 38th annual meeting of Japan Neuroscience Society 

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    Event date： 2015.7

    Language：English   Presentation type：Poster presentation  

  • Ran Yamaguchi, Sodemi Ishikawa, Shogo Tashiro, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani   Odornat X-induced analgesia is not stress-induced analgesia in mice  

    The 92nd Annual Meeting of the Physiological Society of Japan  The 92nd Annual Meeting of the Physiological Society of Japan

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    Event date： 2015.3

    Language：English   Presentation type：Poster presentation  

    Venue：兵庫  

    国内学会

  • Keiichiro Nagata, Shogo Tashiro, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani   The analgesic effect of odorant-X is concentration-dependent   International conference

    The 92nd Annual Meeting of the Physiological Society of Japan  The 92nd Annual Meeting of the Physiological Society of Japan

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    Event date： 2015.3

    Language：English   Presentation type：Poster presentation  

    Venue：兵庫  

    国際学会

  • Shogo Tashiro, Hideki Kashiwadani, Yuichi Kanmura, Tomoyuki Kuwaki   The odor-induced antinociceptive effect is mediated by orexin neurons   International conference

    IASP 15th World Congress on Pain  IASP 15th World Congress on Pain

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    Event date： 2014.10

    Language：English   Presentation type：Poster presentation  

    Venue：Buenos Aires  

    国際学会

  • 山口蘭、田代章吾、加治屋勝子、上村裕一、桑木共之、柏谷英樹   視床下部オレキシンニューロンを介した匂い誘発性鎮痛の発現  

    第37回日本神経科学学会  第37回日本神経科学学会

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    Event date： 2014.9

    Language：Japanese  

    Venue：神奈川  

    国内学会

  • Hideki Kashiwadani, Shogo Tashiro, Ran Yamaguchi, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki   Odor-induced analgesic effect in mice   International conference

    9th FENS forum of neuroscience  9th FENS forum of neuroscience

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    Event date： 2014.7

    Language：English  

    Venue：イタリア  

    国際学会

  • Hideki Kashiwdani, Shogo Tashiro, Yuichi Kanmura, Tomoyuki Kuwaki   Odor-induced analgesia in mouse  

    The 91st Annual Meeting of the Physiological Society of Japan  The 91st Annual Meeting of the Physiological Society of Japan

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    Event date： 2014.3

    Language：Japanese  

    Venue：鹿児島  

    国内学会

  • Shogo Tashiro, Hideki Kashiwadani, Yuichi Kanmura, Tomoyuki Kuwaki   Orexin neurons are involved in antinociceptive effect of olfactory input  

    The 91st Annual Meeting of the Physiological Society of Japan  The 91st Annual Meeting of the Physiological Society of Japan

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    Event date： 2014.3

    Language：Japanese  

    Venue：鹿児島  

    国内学会

  • 田代章悟、柏谷英樹、上村裕一、桑木共之   オレキシン神経は匂い誘発性鎮痛に関与する  

    第7回桜ヶ丘地区(基礎系)研究発表会  第7回桜ヶ丘地区(基礎系)研究発表会

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    Event date： 2014.1

    Language：Japanese  

    Venue：鹿児島  

    研究会

  • 田代章悟、柏谷英樹、上村裕一、桑木共之   オレキシン神経は嗅覚入力による抗侵害受容作用に関与する  

    第41回自律神経生理研究会  第41回自律神経生理研究会

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    Event date： 2013.12

    Language：Japanese  

    Venue：東京  

    研究会

  • 田代章悟、柏谷英樹、上村裕一、桑木共之   嗅覚系を介した鎮痛効果  

    鹿児島神経科学研究会第3回研究発表会  鹿児島神経科学研究会第3回研究発表会

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    Event date： 2013.7

    Language：Japanese  

    Venue：鹿児島  

    研究会

  • Kashiwadani, H., and Mori, K   Olfactory cortex pyramidal cells switch the dendritic segment receiving dominant excitatory input for spike generation depending on the brain state in urethane-anesthetized rat   International conference

    Society for Neuroscience 41st annual meeting  Society for Neuroscience 41st annual meeting

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    Event date： 2011.11

    Language：English  

    Venue：米国  

    国際学会

  • Hideki Kashiwadani, Kensaku Mori   Neuronal mechanisms underlying synchronous activity of olfactor cortex neurons associated with olfactory cortex sharp waves  

    34th annual meeting of the Japan Neuroscience Society  34th annual meeting of the Japan Neuroscience Society

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    Event date： 2011.9

    Language：Japanese  

    Venue：神奈川  

    国内学会

  • Hideki Kashiadani, Shu Kikuta, Kensaku Mori   Alteration of sharp wave generation after mono-nasal closure in rat  

    33rd annual meeting of the Japan Neuroscience Society  33rd annual meeting of the Japan Neuroscience Society

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    Event date： 2010.9

    Language：Japanese  

    Venue：兵庫  

    国内学会

  • Shu Kikuta, Kenichiro Sato, Hideki Kashiwadani, Tatsuya Yamasoba, Kensaku Mori   Anterior olfactory nucleus pars externa neurons detect the difference in the concentration between ipsi-nostril and contra-nostril inputs  

    33rd annual meeting of the Japan Neuroscience Society  33rd annual meeting of the Japan Neuroscience Society

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    Event date： 2010.9

    Language：Japanese  

    Venue：兵庫  

    国内学会

  • Kenichiro Sato, Shu Kikuta, Hideki Kashiawdani, Tatsuya Yamasoba, Kensaku Mori   Spatial representation of odorant categories for the odor-source localization in the anterior olfactory nucleus pars externa  

    33rd annual meeting of the Japan Neuroscience Society  33rd annual meeting of the Japan Neuroscience Society

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    Event date： 2010.9

    Language：Japanese  

    Venue：兵庫  

    国内学会

  • 菊田周、柏谷英樹、角田晃一、山岨達也、森憲作   ラット嗅皮質ニューロンの応答特性に基づいた細胞形態の観察  

    日本鼻科学会  日本鼻科学会

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    Event date： 2010.8

    Language：Japanese  

    Venue：北海道  

    国内学会

  • 菊田周、柏谷英樹、角田晃一、山岨達也、森憲作   脳の内部状態に依存しない左右嗅覚入力差分検出に関与する嗅皮質ニューロン  

    日本耳鼻咽喉科学会  日本耳鼻咽喉科学会

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    Event date： 2010.5

    Language：Japanese  

    Venue：宮城  

    国内学会

  • 菊田周、柏谷英樹、角田晃一、山岨達也、森憲作   匂い源の左右方向感知に関与するラット嗅皮質ニューロン  

    日本鼻科学会  日本鼻科学会

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    Event date： 2009.10

    Language：Japanese  

    Venue：島根  

    国内学会

  • Hideki Kashiwadani, Shu Kikuta, Kensaku Mori   Two types of olfactory cortex neurons with different signal processing mode during slow wave state  

    32nd annual meeting of the Japan Neuroscience Society  32nd annual meeting of the Japan Neuroscience Society

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    Event date： 2009.9

    Language：Japanese  

    Venue：愛知  

    国内学会

  • Shu Kikuta, Hideki Kashiwadani, Kensaku Mori   Three types of bi-nasal interactions in the anterior olfactory nucleus  

    31st annual meeting of the Japan Neuroscience Society  31st annual meeting of the Japan Neuroscience Society

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    Event date： 2008.9

    Language：Japanese  

    Venue：東京  

    国内学会

  • Hiroyuki Manabe, Hideki Kashiwadani, Kensaku Mori   Neocortex-independent slow-wave activity in the olfactory cortex: a study with freely behaving rats  

    31st annual meeting of the Japan Neuroscience Society  31st annual meeting of the Japan Neuroscience Society

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    Event date： 2008.9

    Language：Japanese  

    Venue：東京  

    国内学会

  • Hideki Kashiwadani, Hiroyuki Manabe, Kensaku Mori   Neocortex-independent slow wave activity in the olfactory cortex: a study with urethane anesthetized rats  

    31st annual meeting of the Japan Neuroscience Society  31st annual meeting of the Japan Neuroscience Society

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    Event date： 2008.9

    Language：Japanese  

    Venue：東京  

    国内学会

  • Yusuke Tsuno, Hideki Kashiwadani, Kensaku Mori   Cholinergic regulation of granule-to-mitral inhibition in the rat olfactory bulb  

    31st annual meeting of the Japan Neuroscience Society  31st annual meeting of the Japan Neuroscience Society

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    Event date： 2008.9

    Language：Japanese  

    Venue：東京  

    国内学会

  • 菊田周、柏谷英樹、森憲作   ラット前嗅核における左右匂い入力の収束の特徴  

    日本耳鼻咽喉科学会  日本耳鼻咽喉科学会

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    Event date： 2008.5

    Language：Japanese  

    Venue：大阪  

    国内学会

  • 柏谷英樹   哺乳類の嗅覚中枢神経回路  

    香りに関する産学フォーラム  香りに関する産学フォーラム

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    Event date： 2008.1

    Language：Japanese  

    Venue：東京  

    研究会

  • Kashiwadani, H., Kikuta, S., and Mori, K   Simultaneous boost up of contra-lateral nasal inputs to neurons in the rat anterior olfactory nucleus after ipsi-lateral nasal obstruction   International conference

    Society for Neuroscience 37th annual meeting  Society for Neuroscience 37th annual meeting

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    Event date： 2007.11

    Language：English  

    Venue：アメリカ  

    国際学会

  • Shu Kikuta, Hideki Kashiwadani, Kimitaka Kaga, Kensaku Mori   Close co-ordination of binasal inputs in the rat anterior olfactory nucleus  

    30th annual meeting of the Japan Neuroscience Society  30th annual meeting of the Japan Neuroscience Society

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    Event date： 2007.9

    Language：Japanese  

    Venue：神奈川  

    国内学会

  • Yusuke Tsuno, Hideki Kashiwadani, Kensaku Mori   Behavioral state-dependent change of granule-to-mitral inhibition in the rat olfactory bulb  

    30th annual meeting of the Japan Neuroscience Society  30th annual meeting of the Japan Neuroscience Society

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    Event date： 2007.9

    Language：Japanese  

    Venue：神奈川  

    国内学会

  • 柏谷英樹   大脳嗅皮質における左右嗅覚入力の切り替え  

    平成19年度生理学研究所研究会「大脳皮質機能単位の神経機構」  平成19年度生理学研究所研究会「大脳皮質機能単位の神経機構」

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    Event date： 2007.1

    Language：Japanese  

    Venue：愛知  

    研究会

  • Kashiwadani, H., and Mori, K   Convergence of olfactory and gustatory information in the rat insular cortex   International conference

    Society for Neuroscience 36th annual meeting  Society for Neuroscience 36th annual meeting

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    Event date： 2006.11

    Language：English  

    Venue：アメリカ  

    国際学会

  • Yusuke Tsuno, Hideki Kashiwadani, Kensaku Mori   Synaptic transmission shows state-dependent change in the urethane-anesthetized rat olfactory bulb  

    29th annual meeting of the Japan Neuroscience Society  29th annual meeting of the Japan Neuroscience Society

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    Event date： 2006.9

    Language：Japanese  

    Venue：京都  

    国内学会

  • Hideki Kashiwadani, Kensaku Mori   Integration of olfactory and oral sensory input in the rat insular cortex  

    29th annual meeting of the Japan Neuroscience Society  29th annual meeting of the Japan Neuroscience Society

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    Event date： 2006.9

    Language：Japanese  

    Venue：京都  

    国内学会

  • Masayoshi Murakami, Hideki Kashiwadani, Yutaka Kirino, Kensaku Mori   State-dependent sensory gating in olfactory cortex  

    第２８回日本分子生物学会年会  第２８回日本分子生物学会年会

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    Event date： 2005.12

    Language：Japanese  

    Venue：福岡  

    国内学会

  • Kashiwadani, H., Miyata, M., Kawakami Y   Thalamic PLCb4 modulates nociceptive response induced by peripheral formalin injection in VPL neurons   International conference

    Society for Neuroscience 32nd annual meeting  Society for Neuroscience 32nd annual meeting

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    Event date： 2002.11

    Language：English  

    Venue：アメリカ  

    国際学会

  • 柏谷英樹   哺乳類嗅覚系の、嗅上皮－嗅球における情報処理機構  

    岡崎国立共同研究機構コンファレンス「脳のバイオインフォマティクス―実験系と理論系のギャップは埋められるのか？―」  岡崎国立共同研究機構コンファレンス「脳のバイオインフォマティクス―実験系と理論系のギャップは埋められるのか？―」

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    Event date： 2002.1

    Language：Japanese  

    Venue：岡崎  

    研究会

  • 柏谷英樹、宮田麻里子、川上順子   末梢カプサイシン刺激に対する視床ニューロンのスパイク応答はPLCβ4によって修飾される  

    第２４回日本神経科学大会  第２４回日本神経科学大会

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    Event date： 2001.9

    Language：Japanese  

    Venue：京都  

    国内学会

  • 柏谷英樹   匂い刺激による嗅球僧帽細胞の同期的発火活動  

    平成11年度生理学研究所研究会「マルチニューロン活動と脳内情報処理」  平成11年度生理学研究所研究会「マルチニューロン活動と脳内情報処理」

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    Event date： 1999.1

    Language：Japanese  

    Venue：愛知  

    研究会

  • Hideki Kashiawdani, Yasnory F. Sasaki, Naoshige Uchida, and Kensaku Mori   Synchronized oscillatory discharges of mitral/tufted cells with overlapping molecular receptive ranges in the rabbit olfactory bulb  

    The 21th annual meeting of the Japan Neuroscience Society  The 21th annual meeting of the Japan Neuroscience Society

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    Event date： 1998.9

    Language：Japanese  

    Venue：東京  

    国内学会

  • 井上 恵理, 田代 章悟, 山口 蘭, 上村 裕一, 桑木 共之, 柏谷 英樹   機械性疼痛に対するOdorant-X香気誘発性鎮痛の効果  

    日本生理学雑誌  2017.2  (一社)日本生理学会

  • 植田 紘貴, 菅 真有, 八木 孝和, 楠本 郁恵, 柏谷 英樹, 桑木 共之, 宮脇 正一   唾液分泌と嚥下の調節機構における内臓感覚の役割  

    日本生理学雑誌  2017.2  (一社)日本生理学会

  • Ueda Hirotaka, Suga Mayu, Yagi Takakazu, Kusumoto-Yoshida Ikue, Kashiwadani Hideki, Kuwaki Tomoyuki, Miyawaki Shouichi   唾液分泌および嚥下反射は迷走神経求心路の活性化により誘発される(Salivation and swallowing-like events are induced by vagal afferent activation in anesthetized rats)  

    The Journal of Physiological Sciences  2017.3  (一社)日本生理学会

  • Kashiwadani Hideki   匂い誘導性情動行動および動機付け行動の神経回路機構　生得的行動から習得的行動まで　香気誘発性鎮痛および抗不安作用(Neural circuit mechanisms of odor-guided emotional and motivated behaviors: from innate to learned behaviors　Odor-induced analgesia and anxiolytic effects)  

    The Journal of Physiological Sciences  2018.3  (一社)日本生理学会

  • 原田 浩輝, 上村 裕一, 桑木 共之, 柏谷 英樹   リナロール香気に誘発される抗不安効果  

    日本生理学雑誌  2018.5  (一社)日本生理学会

  • Kaneko Tatsuroh, Kuwaki Tomoyuki, Kashiwadani Hideki   マウスの痒みによる掻爬行動に対するにおいによる鎮痒効果(Odor induced anti-pruritic effect on pruritogen-induced scratching behavior in mice)  

    The Journal of Physiological Sciences  2020.3  (一社)日本生理学会

  • Higa Yurina, Sugimura Mitsutaka, Kuwaki Tomoyuki, Kashiwadani Hideki   マウスにおけるリナロール香による鎮痛の持続(Duration of linalool odor-induced analgesia in mice)  

    日本歯科麻酔学会雑誌  2018.9  (一社)日本歯科麻酔学会

  • Higa Yurina, Sugimura Mitsutaka, Kuwaki Tomoyuki, Kashiwadani Hideki   マウスにおけるリナロール臭気誘発性鎮痛への下降性オレキシン作動性疼痛抑制の関与(Descending orexinergic inhibition contributes to the linalool odor-induced analgesia in mice)  

    The Journal of Physiological Sciences  2019.6  (一社)日本生理学会

  • 金子 達朗, 桑木 共之, 柏谷 英樹   マウスにおけるリナロールの匂いに誘発される抗そう痒効果(Linalool odor induced anti-pruritic effects in mice)  

    医学教育  2020.7  (一社)日本医学教育学会

  • Harada Hiroki, Kanmura Yuichi, Kuwaki Tomoyuki, Kashiwadani Hideki   マウスにおけるOdorant-Z曝露による抗不安効果(Odorant-Z exposure showed anxiolytic effects in mice)  

    The Journal of Physiological Sciences  2017.3  (一社)日本生理学会

  • 金子 達朗, 柏谷 英樹, 桑木 共之   ストレスと中枢自律神経応答　視床下部オレキシン神経は、痛みと痒みを逆方向に制御する  

    日本自律神経学会総会プログラム・抄録集  2022.10  日本自律神経学会

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    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

  • Kashiwadani Hideki, Ueno Sho, Kuwaki Tomoyuki   Chronic activation of hypothalamic orexin neurons in menopause model mice(タイトル和訳中)  

    The Journal of Physiological Sciences  2023.5  (一社)日本生理学会

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    Language：English  

  • Kaneko Tatsuroh, Oura Asuka, Kusumoto-Yoshida Ikue, Kanekura Takuro, Okuno Hiroyuki, Kuwaki Tomoyuki, Kashiwadani Hideki   痒み研究の新展開　痒みと痛みのneural processingにおけるオレキシン神経の役割(New insights into itch research　The contrasting roles of orexin neurons in itch and pain neural processing)   Invited International conference

    The Journal of Physiological Sciences  2024.5  (一社)日本生理学会

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    Language：English   Presentation type：Symposium, workshop panel (nominated)  

  • Kashiwadani Hideki, Ueno Sho, Kuwaki Tomoyuki   更年期障害モデルマウスにおける視床下部オレキシン神経の慢性的活性化(Chronic activation of hypothalamic orexin neurons in menopause model mice)   International conference

    The Journal of Physiological Sciences  2023.5  (一社)日本生理学会

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    Language：English   Presentation type：Poster presentation  

  • Oura Asuka, Kaneko Tatsuroh, Kanekura Takuro, Kuwaki Tomoyuki, Kashiwadani Hideki   慢性そう痒における視床下部オレキシン神経の役割(The role of orexin neurons in the regulation of chronic itch processing)   International conference

    The Journal of Physiological Sciences  2024.5  (一社)日本生理学会

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    Language：English   Presentation type：Oral presentation (general)  

  • Ueno Sho, Kaneko Tatsuroh, Kuwaki Tomoyuki, Kashiwadani Hideki   マウスにおけるリナロール香気曝露による鎮痒効果(Anti-pruritic effects of linalool odor exposure in mice)   International conference

    The Journal of Physiological Sciences  2024.5  (一社)日本生理学会

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    Language：English   Presentation type：Oral presentation (general)  

  • マークル 遥, 桑木 共之, 柏谷 英樹   ゲラニオール香気による月経前症候群の抑うつ緩和  

    日本生理学雑誌  2023.5  (一社)日本生理学会

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    Language：English   Presentation type：Oral presentation (general)  

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Awards

  • 入澤記念JPS優秀論文賞

    2023.3   日本生理学会  

    金子達朗、桑木共之、柏谷英樹

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    Award type：Honored in official journal of a scientific society, scientific journal  Country：Japan

Research Projects

  • 掻痒掻破行動を制御するオレキシン神経系の神経回路機構

    Grant number：23K06015  2023.4 - 2026.3

    JSPS  科学研究費助成金  基盤研究（C）

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    Authorship：Principal investigator  Grant type：Competitive

  • 痛みを増強・抑制する２つの視床-皮質回路の、青斑核によるバランシング機構の解明

    Grant number：22K09916  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    倉本 恵梨子, 大野 幸, 後藤 哲哉, 柏谷 英樹

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    Authorship：Coinvestigator(s)  Grant type：Competitive

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

  • Positive emotion strengthening by estrogen

    Grant number：22K07330  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

  • "痛み"認知における,高次視床核を介した大脳皮質シンクロ活動の関与と除痛への応用

    Grant number：19K10058  2019.4 - 2022.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    倉本 恵梨子, 大野 幸, 後藤 哲哉, 柏谷 英樹, 杉村 光隆

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    ”痛み”を感じている人の脳では、視床、そして大脳皮質の体性感覚野と島皮質が、特に活発な活動を示す。体性感覚野が司る識別感覚と、島皮質で処理される不快感という、分割された2種類の情報が再び一つに統合されて、”痛み”の認知を生じると考えられているが、そのメカニズムは未だ不明である。本研究では、情報を統合するメカニズムとして、視床核の一つであるPosterior nuclei (PO, 視床後核群)の、特に尾側部のニューロンが、体性感覚野と島皮質の両方に同時に出力し、シンクロ活動を誘発することで、2種類の情報が統合され、”痛み”として認知されるという仮説を検証する。
    初年度は、外傷後有痛性ニューロパチーマウスを作製し、行動解析、形態学的解析、電気生理学的な解析を行う予定であった。しかし、実験計画を少し変更し、次年度以降に必要となる、光遺伝学の実験技術の習得と、実験系のセットアップを先に行うことにした。光遺伝学・行動解析・電気生理学の技術を融合し、全てを同時に解析する実験技術を確立するため、HungaryのProfessor Acsadyと、国際共同研究を立ち上げた。この国際共同研究において、本研究に必要な実験のセットアップをほぼ確立することができた。具体的には、マウスの特定の神経細胞に光活性化チャネルを発現するアデノ随伴ウイルスを感染させ、これを刺激するためのoptic-fiberと、神経活動を記録するための電極の埋入、そして、オンラインでマウスの行動を解析し、特定の行動をしたときに、自動的に光刺激が行われる、closed loop systemを完成させた。

  • リナロール香気の抗不安作用と中枢神経回路基盤の解明

    Grant number：17K01988  2017.4 - 2020.3

    JSPS  科学研究費補助金  基盤研究(C)

    柏谷英樹、桑木共之

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    Authorship：Principal investigator  Grant type：Competitive

  • 運動野からのトップダウン的痛覚抑制機序の解明: 三叉神経痛の治療法開発へ向けて

    2016.4

    科学研究費補助金  基盤研究(C)

  • 匂い誘発性鎮痛の中枢神経回路メカニズム

    Grant number：26670290  2014.4 - 2016.3

    JSPS  科学研究費補助金  挑戦的萌芽研究

    柏谷英樹、桑木共之

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    Grant type：Competitive

  • 香り誘発性鎮痛の視床下部オレキシンニューロンによる調節

    2013.4 - 2015.3

    公益財団法人コスメトロジー研究振興財団  コスメトロジー研究振興財団　研究助成金 

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    Grant type：Competitive

    香り誘発性鎮痛の視床下部オレキシンニューロンによる調節

  • 香り誘発性鎮痛の神経機構

    2013.4 - 2014.3

    その他機関  金原一郎記念医学医療振興財団　研究助成金 

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    Grant type：Competitive

    香り誘発性鎮痛の神経機構

  • 嗅覚入力による疼痛制御及び自律神経系制御の神経メカニズム

    2013.4 - 2014.3

    その他機関  児玉記念基礎医学研究助成基金　研究助成金 

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    Grant type：Competitive

    嗅覚入力による疼痛制御及び自律神経系制御の神経メカニズム

  • 島皮質における味覚と嗅覚の統合

    2007.4 - 2008.3

    科学研究費補助金  若手研究(B)

  • 睡眠覚醒、空腹満腹状態に依存した嗅覚神経系の情報処理モード変換機構

    2006.4 - 2010.3

    科学研究費補助金  基盤研究(S)

  • 嗅球僧帽細胞の匂い応答のアセチルコリン性入力による制御

    2004.4 - 2005.3

    科学研究費補助金  若手研究(B)

  • 匂い刺激に対する僧帽細胞群の同期発火活動の匂い経験による変化

    2002.4 - 2003.3

    科学研究費補助金  若手研究(B)

  • 脳における「匂い地図」と「嗅覚記憶」の解析

    2001.4 - 2005.3

    科学研究費補助金  学術創生研究費

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Teaching Experience

  • Physiology

    Institution：Kagoshima University

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    Level：Undergraduate (specialized)  Country：Japan

  • 生理学

    Institution：東京女子医科大学

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    Level：Undergraduate (specialized)  Country：Japan

  • Physiology

    Institution：Kagoshima University

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    Level：Undergraduate (specialized)  Country：Japan

  • 生理学実習

    Institution：東京女子医科大学

  • Physiology

    Institution：The University of Tokyo

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    Level：Undergraduate (specialized)  Country：Japan

  • 生理学実習

    Institution：東京大学

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    Level：Undergraduate (specialized)  Country：Japan

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Social Activities

  • 出前授業

    Role(s)： Lecturer

    鹿児島県立松陽高等学校  2018.7

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    Audience： High school students

    Type：Visiting lecture

  • 南日本新聞取材

    Role(s)： Media coverage,　Informant

    南日本新聞社  2016.11

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    Audience： General

    Type：Newspaper, magazine

Media Coverage

  • 朝日新聞取材 Newspaper, magazine

    朝日新聞  朝日新聞  2018.11

  • The New York Times 取材 Newspaper, magazine

    The New York Times  The New York Times  2018.10

  • 南日本新聞取材 Newspaper, magazine

    南日本新聞  南日本新聞  2018.10

  • KKB取材、出演 TV or radio program

    KKB  2016.2