所属
医歯学域医学系 医歯学総合研究科 先進治療科学専攻 神経病学講座 講師
職名
講師
ジヨ ケングン
徐 建軍
Jian-Jun Xu
学位
-
博士（医学） （ 2005年3月 鹿児島大学 ）
研究キーワード
-
ATP
-
リン酸化
-
カルモジュリン
-
カルシウムチャネル
研究分野
-
その他 / その他 / 電気生理学
-
ライフサイエンス / 分子生物学
学歴
-
鹿児島大学
2001年4月 - 2005年3月
国名： 日本国
経歴
-
鹿児島大学 医歯学域医学系 医歯学総合研究科 先進治療科学専攻 講師
2015年11月 - 現在
-
鹿児島大学 医歯学域医学系 医歯学総合研究科 先進治療科学専攻 助教
2010年1月 - 2015年10月
所属学協会
-
米国生物物理学会
2015年10月 - 現在
-
日本生理学会
2015年10月 - 現在
留学歴
-
2006年7月 - 2009年12月 アメリカのヒューストンのベイラー医科大学 ポストドクター
-
2005年6月 - 2006年6月 アメリカのメンフィスのテネシー大学 ポストドクター
論文
-
Masaki Kameyama, Etsuko Minobe, Dongxue Shao, Jianjun Xu, Qinghua Gao, Liying Hao . Regulation of Cardiac Cav1.2 Channels by Calmodulin . International Journal of Molecular Sciences24 (7) ( 6409 ) 1 - 28 2023年3月招待 査読 国際共著
-
Xu Janjun, Minobe Etsuko, Kameyama Masaki . Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease . Frontiers in Cellular Neuroscience16 ( 867385 ) 1 - 15 2022年4月査読
-
Jia W, Liu J, Yu Z, Zhang X, Xu X, Wang Y, Gao Q, Feng R, Wan Y, Xu J, Minobe E, Kameyama M, Wang W, Guo F . Properties of Calmodulin Binding to Nav1.2 IQ Motif and Its Autism-Associated Mutation R1902C . Neurochemical Research46 ( 3 ) 523 - 534 2021年1月査読 国際共著
-
Gao Qinghua, Minobe Etsuko, Kameyama Masaki*, Xu Jianjun* . Purification of insoluble GST-fused and GST-cleaved Cav1.2 channel fragment by denaturation and renaturation. . Protein Expression and Purification160 7 - 10 2019年3月査読
-
Li J, Yu Z, Xu J, Feng R, Gao Q, Boczek T, Liu J, Li Z, Wang Q, Lei M, Gong J, Hu H, Minobe E, Ji HL, Kameyama M, Guo F . The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to Nav1.1 . Int J Mol Sci19 ( 9 ) 2018年8月査読
-
Lei M, Xu J*, Gao Q, Minobe E, Kameyama M, Hao L* . PKA phosphorylation of Cav1.2 channel modulates the interaction of calmodulin with the C terminal tail of the channel. . J Pharmacol Sci137 ( 2 ) 187 - 194 2018年6月査読
-
Wu M, Takemoto M, Luo H, Xu JJ, Lu MH, Kameyama M, Takumi T, Song WJ . A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1 . European Journal of Pharmacology 824 99 - 107 2018年4月査読
-
Lyu L, Gao Q, Xu J, Minobe E, Zhu T, Kameyama M . A new interaction between proximal and distal C-terminus of Cav1.2 channels. . Journal of Pharmacological Sciences 2017年3月査読
-
Chang Seok Lee, Amy D. Hanna, Hui Wang, Adan Dagnino-Acosta, Aditya D. Joshi, Mark Knoblauch, Yan Xia, Dimitra K. Georgiou, Jianjun Xu, Cheng Long, Hisayuki Amano, Corey Reynolds, Keke Dong, John C. Martin, William R. Lagor, George G. Rodney, Ergun Sahin, Caroline Sewry & Susan L. Hamilton . A chemical chaperone improves muscle function in mice with a RyR1 mutation. . Nature Communication 2017年3月査読
-
Yu L, Xu J, Minobe E, Kameyama A, Yang L, Feng R, Hao L, Kameyama M. . Role of protein phosphatases in the run down of guinea pig cardiac Cav1.2 Ca2+ channels. . American Journal of Physiology Cell Physiology310 ( 10 ) C773 - C779 2016年5月査読
-
Xu J, Yu L, Minobe E, Lu L, Lei M, Kameyama M. . PKA and phosphatases attached to the Ca(V)1.2 channel regulate channel activity in cell-free patches. . American Journal of Physiology Cell Physiology310 ( 2 ) C136 - C141 2016年1月査読
-
Sun Y, Xu J, Minobe E, Shimoara S, Hao L, Kameyama M. . Regulation of the Cav1.2 cardiac channel by redox via modulation of CaM interaction with the channel. . Journal of Pharmacological Sciences128 ( 3 ) 137 - 143 2015年7月査読
-
Shu-yuan Liu, Jian-jun Xu, Etsuko Minobe, Qing-hua Gao, Rui Feng, Mei-mi Zhao, Feng Guo, Lei Yang, Li-ying Hao, Masaki Kameyama . Nucleotides maintain the activity of Cav1.2 channels in guinea-pig ventricular myocytes. . Biochemical and Biophysical Research Communications460 ( 3 ) 813 - 818 2015年5月査読
-
Minobe E, Maeda S, Xu J, Hao L, Kameyama A, Kameyama M. . A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation. . Am J Physiol Cell Physiol306 ( 9 ) C856 - C863 2014年12月査読
-
Shao D, Zhao M, Xu J, Feng R, Guo F, Hu H, Sun X, Gao Q, He G, Sun W, Wang H, Yu L, Liu S, Zhu Y, Minobe E, Zhu T, Kameyama M, Hao L. . The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart. . FEBS Lett588 ( 21 ) 3855 - 3861 2014年11月査読
-
Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL. . Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function . J Biol Chem289 ( 37 ) 25556 - 25570 2014年9月査読
-
Feng R, Xu J, Minobe E, Kameyama A, Yang L, Yu L, Hao L, Kameyama M. . Adenosine triphosphate regulates the activity of guinea pig Cav1.2 channel by direct binding to the channel in a dose-dependent manner. . Am J Physiol Cell Physiol 2014年2月査読
-
Yang L, Xu J, Minobe E, Yu L, Feng R, Kameyama A, Yazawa K, Kameyama M. . Mechanisms underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea pig ventricular myocytes. . J Physiol Sci. 2013年7月査読
-
Han DY, Minobe E, Wang WY, Guo F, Xu JJ, Hao LY, Kameyama M. . Calmodulin- and Ca2+-dependent facilitation and inactivation of the Cav1.2 Ca2+ channels in guinea-pig ventricular myocytes. . J Pharmacol Sci.112 ( 3 ) 310 - 319 2010年査読
-
Hao LY, Wang WY, Minobe E, Han DY, Xu JJ, Kameyama A, Kameyama M. . The distinct roles of calmodulin and calmodulin kinase II in the reversal of run-down of L-type Ca2+ channels in guinea-pig ventricular myocytes. . J Pharmacol Sci.111 ( 4 ) 416 - 425 2009年査読
-
Hao LY, Xu JJ, Minobe E, Kameyama A, Kameyama M. . Calmodulin kinase II activation is required for the maintenance of basal activity of L-type Ca2+ channels in guinea-pig ventricular myocytes. . J Pharmacol Sci.108 ( 3 ) 290 - 300 2008年査読
-
Nie HG, Hao LY, Xu JJ, Minobe E, Kameyama A, Kameyama M. . Distinct roles of CaM and Ca(2+)/CaM -dependent protein kinase II in Ca(2+) -dependent facilitation and inactivation of cardiac L -type Ca2+ channels. . J Physiol Sci.57 ( 3 ) 167 - 173 2007年査読
-
Minobe E, Hao LY, Saud ZA, Xu JJ, Kameyama A, Maki M, Jewell KK, Parr T, Bardsley RG, Kameyama M. . A region of calpastatin domain L that reprimes cardiac L-type Ca2+ channels. . Biochem Biophys Res Commun.348 ( 1 ) 288 - 288 2006年1月査読
-
Zhou FW, Xu JJ, Zhao Y, LeDoux MS, Zhou FM. . Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata. . J Neurophysiol.96 ( 3 ) 1581 - 1581 2006年査読
-
Jian-Jun Xu, Li-Ying Hao, Asako Kameyama, Masaki Kameyama . Calmodulin reverses rundown of L-type Ca(2+) channels in guinea pig ventricular myocytes. . American Journal of Physiology Cell Physiology287 ( 6 ) C1717 - C1724 2004年11月査読
MISC
-
心筋L型Ca2+ チャネルの調節: カルモジュリンとATPによるL型Cav1.2 チャネルの調節 査読
亀山正樹、蓑部悦子、徐建軍、韓冬雲、Hadhimulya Asmara、亀山亜砂子、封瑞、劉書源、ハオ麗英
日本薬理学雑誌 144 ( 5 ) 222 - 226 2014年11月
講演・口頭発表等
-
Xu Jianjun, Minobe Etsuko, Sun Yu, Lu liting, Lei Ming, Yazawa Kazuto, Kameyama Masaki . PKA-mediated facilitation of cardiac Cav1.2 channel through uncovering calmodulin binding sites by distal C-terminus of alpha 1c subunit . 日本生理学会 日本生理学会
-
Sun Yu, Xu jianjun, Minobe Etsuko, Shimoara Shoken, Hao Liying, Kameyama Masaki . Regulation of cardiac Cav1.2 channel by redox via modulation of CaM interaction with channel . 日本生理学会 日本生理学会
-
Dongxue Shao, Jianjun Xu, Meimi Zhao, Etsuko Minobe, Liying Hao, Masaki Kameyama . Lobe-specific interaction of calmodulin with C-terminal tails of cardiac Cav1.2 channel . 西日本生理学会 西日本生理学会
-
Kameyama Masaki, Feng Rui, Liu Shuyuan, Minobe Etsuko, Xu Jianjun, Kameyama Asako and Hao Liying . Regulation of L-type Cav1.2 channels by ATP . 日本生理学大会 日本生理学大会
-
Minobe Etsuko, Han Dongyun, Asmara Hadhimulya, Feng Rui, Xu jianjun, Kameyama Masaki . Regulation and molecular mechanisms of Cav1.2 channel by calmodulin and ATP . 日本生理学大会 日本生理学大会
-
Liu Shuyuan, Xu Jianjun, Minobe Etsuko, Kameyama Asako, Hao Liying and Kameyama Masaki . The role of nucleotides in regulation of cardiac Cav1.2 channel . 日本生理学大会 日本生理学大会
-
Shao Dongxue, Xu Jianjun, Zhao Meimi, Sun Yu, Minobe Etsuko, He Guilin, Feng Rui, Hu Huiyuan, Sun Xuefei, Guo Feng, Kameyama Masaki, and Hao Liying . The Lobe-specific interaction of calmodulin with cardiac Cav1.2 channel . 日本生理学大会 日本生理学大会
-
Rui Feng, Shuyuan Liu, Jian-jun Xu, Etsuko Minobe, Asako Kameyama,Li-ying Hao and Masaki Kameyama1 . Properties of the ATP-binding site responsible for regulation of cardiac Ca2+ channels . 西日本生理学会 西日本生理学会
-
Xu Jianjun, Minobe Etsuko, Yang Lei, Yu Lifeng, Yazawa Kazuto, Kameyama A & Kameyama Masaki . PKA modulates Ca2+ channel activity induced by calmodulin in guinea-pig ventricular myocytes . 日本生理学大会 日本生理学大会
-
Yu LF, Xu JJ, Minobe E, Yang L, Kameyama A, Yazawa K, Hao LY & Kameyama M . Phospjorylation state determines calmodulin-induced activity of Cav1.2 Ca2+ channels . 西日本生理学会 西日本生理学会
-
Yang L, Xu JJ, Minobe E, Feng R, Kameyama A, Yazawa K and Kameyama M. . Mechanism underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea-pig ventricular myocytes. . 日本生理学大会 日本生理学大会
-
Minobe E, Maeda S, Xu JJ, Hao LY, Feng R, Yazawa K, Kameyama A and Kameyama M. . Multiple funtional phosphorylation sites of protein kinase A in the C-terminal tail of Cav1.2 channel. . 日本生理学大会 日本生理学大会
-
Kameyama M, Minobe E, Asmara H, Saud ZA, Han DY, Xu JJ, Kameyama A, Hao LY. . Multiple molecules of calmodulin are involved in the regulation of Cav1.2 channel. . Japan-Korea Joint Symposium Japan-Korea Joint Symposium国際会議
-
Yang L, Xu JJ, Minobe E, Feng R, Kameyama A, Yazawa K and Kameyama M. . CaMKII-dependent and independent facilitation of L-type Ca2+ channels by hydrogen peroxide inguinea-pig ventricular myocytes. . 西日本生理学会 西日本生理学会
-
Yang L, Xu JJ, Minobe E, Feng R, Kameyama A. Yazawa, K and Kameyama M. . Facilitation of L-type Ca2+ channels by hydrogen peroxide in guinea-pig ventricular myocytes. . The 5th biennial meeting of society for free radical research-Asia The 5th biennial meeting of society for free radical research-Asia国際会議
-
Xu JJ, Zahangir A, Liu Y, Yang L, Minobe E, Kameyama A, Yazawa K, Hao LY and Kameyama M. . Both PKA-mediated phosphorylation and calmodulin interaction are required for basal activity of cardiac L-type Ca2+ channel. . 日本生理学会大会 日本生理学会大会
-
蓑部悦子、森誠之、徐建軍、亀山正樹 . カルモジュリンをリンクさせたCav1.2型Ca2+チャネルのCa2+依存性調節 . 生理学研究所研究会 生理学研究所研究会
-
Xu JJ, Zahangir A, Liu Y, Yang L, Minobe E, Kameyama A, Yazawa K, Hao LY and Kameyama M. . PKA-mediated phosphorylation modulates the interaction of calmodulin with cardiac Cav1.2 Ca2+ channel. . The 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles The 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles国際会議
-
Joshi AD, Ji RR, Xu JJ, Long C and Hamilton SL. . Role of Oxidative Stress, Autophagy and Apoptosis in the I4895T RyR1 Knockin Mice. . Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society国際会議
-
Long C, Xu JJ, Lanner J, Dong KK and Hamilton SL. . Regulation of E-C Coupling Via TβRI and FKBP12. . Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society国際会議
-
Lanner JT, Long C, Xu JJ, Baker MR and Hamilton SL . AICAR Prevents Heat-Induced Death in Mice with Malignant Hyperthermia. . Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society国際会議
-
Long C, Durham W, Xu JJ, Ji RR, Dong KK, Yang GJ, Wu GY and Hamilton SL . Biphasic Effects of FKBP12 on RyR1 Activity. . Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society国際会議
-
Xu JJ, Ji RR, Long C, Durham W, Cheng Q, Dong KK, Yang GJ and Hamilton SL . Muscle from mice heterozygous for a mutation that abolishes FKBP12 binding to RyR1 fatigue more slowly than wild type muscle. . Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society国際会議