Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Neurology Lecturer
Title
Lecturer
Jian-Jun Xu
Degree
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博士（医学） ( 2005.3 鹿児島大学 )
Research Interests
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ATP
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phosphorylation
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calmodulin
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calcium channel
Research Areas
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Others / Others / 電気生理学
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Life Science / Molecular biology
Education
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Kagoshima University
2001.4 - 2005.3
Country： Japan
Research History
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Kagoshima University Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Lecturer
2015.11
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Kagoshima University Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Assistant Professor
2010.1 - 2015.10
Professional Memberships
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米国生物物理学会
2015.10
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日本生理学会
2015.10
Studying abroad experiences
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2006.7 - 2009.12 Baylor College of Medicine in Houston in USA Postdoctor
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2005.6 - 2006.6 Tennessee University in Memphis in USA
Papers
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Xin Tong, Yu Tong, Jiahe Zheng, Ruixue Shi, Hongyue Liang, Meixuan Li, Yulu Meng, Jian Shi, Dongyi Zhao, Corey Ray Seehus, Jialu Wang, Xiaoxue Xu, Tomasz Boczek, Sayuri Suzuki, Andrea Fleig, Reinhold Penner, Naining Zhang, Jianjun Xu, Jingjing Duan, Zhiyi Yu, Wuyang Wang, Weidong Zhao & Feng Guo . TRPM7 contributes to pyroptosis and its involvement in status epilepticus . Journal of Neuroinflammation12 (1) ( 315 ) 2024.12TRPM7 contributes to pyroptosis and its involvement in status epilepticusReviewed International coauthorship
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Masaki Kameyama, Etsuko Minobe, Dongxue Shao, Jianjun Xu, Qinghua Gao, Liying Hao . Regulation of Cardiac Cav1.2 Channels by Calmodulin . International Journal of Molecular Sciences24 (7) ( 6409 ) 1 - 28 2023.3Regulation of Cardiac Cav1.2 Channels by CalmodulinInvited Reviewed International coauthorship
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Xu Janjun, Minobe Etsuko, Kameyama Masaki . Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease . Frontiers in Cellular Neuroscience16 ( 867385 ) 1 - 15 2022.4Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s DiseaseReviewed
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Jia W, Liu J, Yu Z, Zhang X, Xu X, Wang Y, Gao Q, Feng R, Wan Y, Xu J, Minobe E, Kameyama M, Wang W, Guo F . Properties of Calmodulin Binding to Nav1.2 IQ Motif and Its Autism-Associated Mutation R1902C . Neurochemical Research46 ( 3 ) 523 - 534 2021.1Properties of Calmodulin Binding to Nav1.2 IQ Motif and Its Autism-Associated Mutation R1902CReviewed International coauthorship
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Gao Qinghua, Minobe Etsuko, Kameyama Masaki*, Xu Jianjun* . Purification of insoluble GST-fused and GST-cleaved Cav1.2 channel fragment by denaturation and renaturation. . Protein Expression and Purification160 7 - 10 2019.3Purification of insoluble GST-fused and GST-cleaved Cav1.2 channel fragment by denaturation and renaturation.Reviewed
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Li J, Yu Z, Xu J, Feng R, Gao Q, Boczek T, Liu J, Li Z, Wang Q, Lei M, Gong J, Hu H, Minobe E, Ji HL, Kameyama M, Guo F . The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to Nav1.1 . Int J Mol Sci19 ( 9 ) 2018.8The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to Nav1.1Reviewed
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Lei M, Xu J*, Gao Q, Minobe E, Kameyama M, Hao L* . PKA phosphorylation of Cav1.2 channel modulates the interaction of calmodulin with the C terminal tail of the channel. . J Pharmacol Sci137 ( 2 ) 187 - 194 2018.6PKA phosphorylation of Cav1.2 channel modulates the interaction of calmodulin with the C terminal tail of the channel.Reviewed
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Wu M, Takemoto M, Luo H, Xu JJ, Lu MH, Kameyama M, Takumi T, Song WJ . A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1 . European Journal of Pharmacology 824 99 - 107 2018.4A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1Reviewed
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Lyu L, Gao Q, Xu J, Minobe E, Zhu T, Kameyama M . A new interaction between proximal and distal C-terminus of Cav1.2 channels. . Journal of Pharmacological Sciences 2017.3A new interaction between proximal and distal C-terminus of Cav1.2 channels.Reviewed
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Chang Seok Lee, Amy D. Hanna, Hui Wang, Adan Dagnino-Acosta, Aditya D. Joshi, Mark Knoblauch, Yan Xia, Dimitra K. Georgiou, Jianjun Xu, Cheng Long, Hisayuki Amano, Corey Reynolds, Keke Dong, John C. Martin, William R. Lagor, George G. Rodney, Ergun Sahin, Caroline Sewry & Susan L. Hamilton . A chemical chaperone improves muscle function in mice with a RyR1 mutation. . Nature Communication 2017.3A chemical chaperone improves muscle function in mice with a RyR1 mutation.Reviewed
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Yu L, Xu J, Minobe E, Kameyama A, Yang L, Feng R, Hao L, Kameyama M. . Role of protein phosphatases in the run down of guinea pig cardiac Cav1.2 Ca2+ channels. . American Journal of Physiology Cell Physiology310 ( 10 ) C773 - C779 2016.5Role of protein phosphatases in the run down of guinea pig cardiac Cav1.2 Ca2+ channels.Reviewed
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Xu J, Yu L, Minobe E, Lu L, Lei M, Kameyama M. . PKA and phosphatases attached to the Ca(V)1.2 channel regulate channel activity in cell-free patches. . American Journal of Physiology Cell Physiology310 ( 2 ) C136 - C141 2016.1PKA and phosphatases attached to the Ca(V)1.2 channel regulate channel activity in cell-free patches.Reviewed
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Sun Y, Xu J, Minobe E, Shimoara S, Hao L, Kameyama M. . Regulation of the Cav1.2 cardiac channel by redox via modulation of CaM interaction with the channel. . Journal of Pharmacological Sciences128 ( 3 ) 137 - 143 2015.7Regulation of the Cav1.2 cardiac channel by redox via modulation of CaM interaction with the channel.Reviewed
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Shu-yuan Liu, Jian-jun Xu, Etsuko Minobe, Qing-hua Gao, Rui Feng, Mei-mi Zhao, Feng Guo, Lei Yang, Li-ying Hao, Masaki Kameyama . Nucleotides maintain the activity of Cav1.2 channels in guinea-pig ventricular myocytes. . Biochemical and Biophysical Research Communications460 ( 3 ) 813 - 818 2015.5Nucleotides maintain the activity of Cav1.2 channels in guinea-pig ventricular myocytes.Reviewed
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Minobe E, Maeda S, Xu J, Hao L, Kameyama A, Kameyama M. . A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation. . Am J Physiol Cell Physiol306 ( 9 ) C856 - C863 2014.12A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation.Reviewed
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Shao D, Zhao M, Xu J, Feng R, Guo F, Hu H, Sun X, Gao Q, He G, Sun W, Wang H, Yu L, Liu S, Zhu Y, Minobe E, Zhu T, Kameyama M, Hao L. . The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart. . FEBS Lett588 ( 21 ) 3855 - 3861 2014.11The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart.Reviewed
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Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL. . Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function . J Biol Chem289 ( 37 ) 25556 - 25570 2014.9Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle functionReviewed
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Feng R, Xu J, Minobe E, Kameyama A, Yang L, Yu L, Hao L, Kameyama M. . Adenosine triphosphate regulates the activity of guinea pig Cav1.2 channel by direct binding to the channel in a dose-dependent manner. . Am J Physiol Cell Physiol 2014.2Adenosine triphosphate regulates the activity of guinea pig Cav1.2 channel by direct binding to the channel in a dose-dependent manner.Reviewed
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Yang L, Xu J, Minobe E, Yu L, Feng R, Kameyama A, Yazawa K, Kameyama M. . Mechanisms underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea pig ventricular myocytes. . J Physiol Sci. 2013.7Mechanisms underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea pig ventricular myocytes.Reviewed
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Han DY, Minobe E, Wang WY, Guo F, Xu JJ, Hao LY, Kameyama M. . Calmodulin- and Ca2+-dependent facilitation and inactivation of the Cav1.2 Ca2+ channels in guinea-pig ventricular myocytes. . J Pharmacol Sci.112 ( 3 ) 310 - 319 2010Calmodulin- and Ca2+-dependent facilitation and inactivation of the Cav1.2 Ca2+ channels in guinea-pig ventricular myocytes.Reviewed
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Hao LY, Wang WY, Minobe E, Han DY, Xu JJ, Kameyama A, Kameyama M. . The distinct roles of calmodulin and calmodulin kinase II in the reversal of run-down of L-type Ca2+ channels in guinea-pig ventricular myocytes. . J Pharmacol Sci.111 ( 4 ) 416 - 425 2009The distinct roles of calmodulin and calmodulin kinase II in the reversal of run-down of L-type Ca2+ channels in guinea-pig ventricular myocytes.Reviewed
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Hao LY, Xu JJ, Minobe E, Kameyama A, Kameyama M. . Calmodulin kinase II activation is required for the maintenance of basal activity of L-type Ca2+ channels in guinea-pig ventricular myocytes. . J Pharmacol Sci.108 ( 3 ) 290 - 300 2008Calmodulin kinase II activation is required for the maintenance of basal activity of L-type Ca2+ channels in guinea-pig ventricular myocytes.Reviewed
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Nie HG, Hao LY, Xu JJ, Minobe E, Kameyama A, Kameyama M. . Distinct roles of CaM and Ca(2+)/CaM -dependent protein kinase II in Ca(2+) -dependent facilitation and inactivation of cardiac L -type Ca2+ channels. . J Physiol Sci.57 ( 3 ) 167 - 173 2007Distinct roles of CaM and Ca(2+)/CaM -dependent protein kinase II in Ca(2+) -dependent facilitation and inactivation of cardiac L -type Ca2+ channels.Reviewed
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Minobe E, Hao LY, Saud ZA, Xu JJ, Kameyama A, Maki M, Jewell KK, Parr T, Bardsley RG, Kameyama M. . A region of calpastatin domain L that reprimes cardiac L-type Ca2+ channels. . Biochem Biophys Res Commun.348 ( 1 ) 288 - 288 2006.1A region of calpastatin domain L that reprimes cardiac L-type Ca2+ channels.Reviewed
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Zhou FW, Xu JJ, Zhao Y, LeDoux MS, Zhou FM. . Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata. . J Neurophysiol.96 ( 3 ) 1581 - 1581 2006Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata.Reviewed
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Jian-Jun Xu, Li-Ying Hao, Asako Kameyama, Masaki Kameyama . Calmodulin reverses rundown of L-type Ca(2+) channels in guinea pig ventricular myocytes. . American Journal of Physiology Cell Physiology287 ( 6 ) C1717 - C1724 2004.11Calmodulin reverses rundown of L-type Ca(2+) channels in guinea pig ventricular myocytes.Reviewed
MISC
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心筋L型Ca2+ チャネルの調節: カルモジュリンとATPによるL型Cav1.2 チャネルの調節 Reviewed
亀山正樹、蓑部悦子、徐建軍、韓冬雲、Hadhimulya Asmara、亀山亜砂子、封瑞、劉書源、ハオ麗英
日本薬理学雑誌 144 ( 5 ) 222 - 226 2014.11
Presentations
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Xu Jianjun, Minobe Etsuko, Sun Yu, Lu liting, Lei Ming, Yazawa Kazuto, Kameyama Masaki PKA-mediated facilitation of cardiac Cav1.2 channel through uncovering calmodulin binding sites by distal C-terminus of alpha 1c subunit
日本生理学会 日本生理学会
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Sun Yu, Xu jianjun, Minobe Etsuko, Shimoara Shoken, Hao Liying, Kameyama Masaki Regulation of cardiac Cav1.2 channel by redox via modulation of CaM interaction with channel
日本生理学会 日本生理学会
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Dongxue Shao, Jianjun Xu, Meimi Zhao, Etsuko Minobe, Liying Hao, Masaki Kameyama Lobe-specific interaction of calmodulin with C-terminal tails of cardiac Cav1.2 channel
西日本生理学会 西日本生理学会
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Kameyama Masaki, Feng Rui, Liu Shuyuan, Minobe Etsuko, Xu Jianjun, Kameyama Asako and Hao Liying Regulation of L-type Cav1.2 channels by ATP
日本生理学大会 日本生理学大会
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Minobe Etsuko, Han Dongyun, Asmara Hadhimulya, Feng Rui, Xu jianjun, Kameyama Masaki Regulation and molecular mechanisms of Cav1.2 channel by calmodulin and ATP
日本生理学大会 日本生理学大会
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Liu Shuyuan, Xu Jianjun, Minobe Etsuko, Kameyama Asako, Hao Liying and Kameyama Masaki The role of nucleotides in regulation of cardiac Cav1.2 channel
日本生理学大会 日本生理学大会
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Shao Dongxue, Xu Jianjun, Zhao Meimi, Sun Yu, Minobe Etsuko, He Guilin, Feng Rui, Hu Huiyuan, Sun Xuefei, Guo Feng, Kameyama Masaki, and Hao Liying The Lobe-specific interaction of calmodulin with cardiac Cav1.2 channel
日本生理学大会 日本生理学大会
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Rui Feng, Shuyuan Liu, Jian-jun Xu, Etsuko Minobe, Asako Kameyama,Li-ying Hao and Masaki Kameyama1 Properties of the ATP-binding site responsible for regulation of cardiac Ca2+ channels
西日本生理学会 西日本生理学会
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Xu Jianjun, Minobe Etsuko, Yang Lei, Yu Lifeng, Yazawa Kazuto, Kameyama A & Kameyama Masaki PKA modulates Ca2+ channel activity induced by calmodulin in guinea-pig ventricular myocytes
日本生理学大会 日本生理学大会
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Yu LF, Xu JJ, Minobe E, Yang L, Kameyama A, Yazawa K, Hao LY & Kameyama M Phospjorylation state determines calmodulin-induced activity of Cav1.2 Ca2+ channels
西日本生理学会 西日本生理学会
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Minobe E, Maeda S, Xu JJ, Hao LY, Feng R, Yazawa K, Kameyama A and Kameyama M. Multiple funtional phosphorylation sites of protein kinase A in the C-terminal tail of Cav1.2 channel.
日本生理学大会 日本生理学大会
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Yang L, Xu JJ, Minobe E, Feng R, Kameyama A, Yazawa K and Kameyama M. Mechanism underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea-pig ventricular myocytes.
日本生理学大会 日本生理学大会
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Kameyama M, Minobe E, Asmara H, Saud ZA, Han DY, Xu JJ, Kameyama A, Hao LY. Multiple molecules of calmodulin are involved in the regulation of Cav1.2 channel. International conference
Japan-Korea Joint Symposium Japan-Korea Joint Symposium
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Yang L, Xu JJ, Minobe E, Feng R, Kameyama A, Yazawa K and Kameyama M. CaMKII-dependent and independent facilitation of L-type Ca2+ channels by hydrogen peroxide inguinea-pig ventricular myocytes.
西日本生理学会 西日本生理学会
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Yang L, Xu JJ, Minobe E, Feng R, Kameyama A. Yazawa, K and Kameyama M. Facilitation of L-type Ca2+ channels by hydrogen peroxide in guinea-pig ventricular myocytes. International conference
The 5th biennial meeting of society for free radical research-Asia The 5th biennial meeting of society for free radical research-Asia
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Xu JJ, Zahangir A, Liu Y, Yang L, Minobe E, Kameyama A, Yazawa K, Hao LY and Kameyama M. Both PKA-mediated phosphorylation and calmodulin interaction are required for basal activity of cardiac L-type Ca2+ channel.
日本生理学会大会 日本生理学会大会
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蓑部悦子、森誠之、徐建軍、亀山正樹 カルモジュリンをリンクさせたCav1.2型Ca2+チャネルのCa2+依存性調節
生理学研究所研究会 生理学研究所研究会
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Xu JJ, Zahangir A, Liu Y, Yang L, Minobe E, Kameyama A, Yazawa K, Hao LY and Kameyama M. PKA-mediated phosphorylation modulates the interaction of calmodulin with cardiac Cav1.2 Ca2+ channel. International conference
The 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles The 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles
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Joshi AD, Ji RR, Xu JJ, Long C and Hamilton SL. Role of Oxidative Stress, Autophagy and Apoptosis in the I4895T RyR1 Knockin Mice. International conference
Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society
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Long C, Xu JJ, Lanner J, Dong KK and Hamilton SL. Regulation of E-C Coupling Via TβRI and FKBP12. International conference
Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society
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Lanner JT, Long C, Xu JJ, Baker MR and Hamilton SL AICAR Prevents Heat-Induced Death in Mice with Malignant Hyperthermia. International conference
Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society
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Long C, Durham W, Xu JJ, Ji RR, Dong KK, Yang GJ, Wu GY and Hamilton SL Biphasic Effects of FKBP12 on RyR1 Activity. International conference
Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society
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Xu JJ, Ji RR, Long C, Durham W, Cheng Q, Dong KK, Yang GJ and Hamilton SL Muscle from mice heterozygous for a mutation that abolishes FKBP12 binding to RyR1 fatigue more slowly than wild type muscle. International conference
Annual Meeting of the American Biophysical Society Annual Meeting of the American Biophysical Society