Updated on 2024/05/15

写真a

 
OHNISHI Tomokazu
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Health Research Course Developmental Medicine Associate Professor
Title
Associate Professor

Degree

  • Ph D ( 1992.12   Kagoshima University )

Research Interests

  • 骨芽細胞

  • 歯周炎

  • 肝細胞増殖因子

  • 病態医科生化学

  • 生体活性物質

  • Pathological Medical Biochemistry

  • keratinocyte

  • COVID-19

Research Areas

  • Life Science / Oral biological science  / Cellular molecular biology

  • Life Science / Molecular biology

  • Life Science / Cell biology

  • Life Science / Pathological biochemistry

  • Life Science / Oral biological science

  • Life Science / Molecular biology

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Education

  • Kagoshima University   Dental School

    - 1988

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    Country: Japan

  • Kagoshima University   Faculty of Dentistry

    - 1988

Research History

  • Kagoshima University   Associate Professor

    2003.4

  • Kagoshima University   Research Assistant

    1992.4

  • Research Associate, Kagoshima University, Dental School

    1992 - 2001

Professional Memberships

  • 歯科基礎医学会

    2015.10

  • 日本骨代謝学会

    2015.10

  • 日本生化学会

    2015.10

  • 歯科基礎医学会

  • 日本骨代謝学会

  • 日本生化学会

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Committee Memberships

  • Japanese Association for Oral Biology   Panelists  

       

Studying abroad experiences

  • 1999.11 - 2001.11   The Johns Hopkins University   Postdoctoral fellow

  • 1996.2 - 1996.4   Johannes Gutenberg-University Mainz   research fellow

 

Papers

  • Chiba N, Noguchi Y, Seong CH, Ohnishi T, Matsuguchi T .  EGR1 plays an important role in BMP9-mediated osteoblast differentiation by promoting SMAD1/5 phosphorylation. .  FEBS letters596 ( 13 ) 1720 - 1732   2022.7

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    Language:English   Publisher:FEBS Letters  

    DOI: 10.1002/1873-3468.14407

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  • Ohnishi T, Nakamura T, Shima K, Noguchi K, Chiba N, Matsuguchi T .  Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). .  Journal of oral biosciences64 ( 2 ) 229 - 236   2022.6

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    Language:English   Publisher:Journal of Oral Biosciences  

    DOI: 10.1016/j.job.2022.04.004

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  • Amir MS, Chiba N, Seong CH, Kusuyama J, Eiraku N, Ohnishi T, Nakamura N, Matsuguchi T .  HIF-1α plays an essential role in BMP9-mediated osteoblast differentiation through the induction of a glycolytic enzyme, PDK1. .  Journal of cellular physiology237 ( 4 ) 2183 - 2197   2022.4

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    Language:English   Publisher:Journal of Cellular Physiology  

    DOI: 10.1002/jcp.30752

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  • Ohnishi T, Hisadome M, Joji K, Chiba N, Amir MS, Kanekura T, Matsuguchi T .  Ultraviolet B irradiation decreases CXCL10 expression in keratinocytes through endoplasmic reticulum stress. .  Journal of cellular biochemistry   2021.4Ultraviolet B irradiation decreases CXCL10 expression in keratinocytes through endoplasmic reticulum stress.Reviewed

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    Authorship:Lead author  

    DOI: 10.1002/jcb.29936

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  • Chang-Hwan Seong, Norika Chiba , Joji Kusuyama Muhammad Subhan Amir, Nahoko Eiraku, Sachiko Yamashita, Tomokazu Ohnishi, Norifumi Nakamura, Tetsuya Matsuguchi .  Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts .  FEBS Lett .595 ( 3 ) 389 - 403   2021.2Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblastsReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/1873-3468.14016

  • Glut1 Expression Is Increased by p53 Reduction to Switch Metabolism to Glycolysis During Osteoblast Differentiation .    477 ( 10 ) 1795 - 1811   2020.5Glut1 Expression Is Increased by p53 Reduction to Switch Metabolism to Glycolysis During Osteoblast DifferentiationReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1042/BCJ20190888

  • Joji Kusuyama, Kenjiro Bandow , Tomokazu Ohnishi , Muhammad Subhan Amir Kaori Shima , Ichiro Semba , Tetsuya Matsuguchi .  CXCL13 Is a Differentiation- And Hypoxia-Induced Adipocytokine That Exacerbates the Inflammatory Phenotype of Adipocytes Through PHLPP1 Induction .  Biochemical Journal476 ( 22 ) 3533 - 3548   2019.11CXCL13 Is a Differentiation- And Hypoxia-Induced Adipocytokine That Exacerbates the Inflammatory Phenotype of Adipocytes Through PHLPP1 InductionReviewed

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  • Joji Kusuyama , Changhwan Seong , Toshiaki Nakamura , Tomokazu Ohnishi, Muhammad Subhan Amir , Kaori Shima, Ichiro Semba , Kazuyuki Noguchi , Tetsuya Matsuguchi .  BMP9 Prevents Induction of Osteopontin in JNK-inactivated Osteoblasts via Hey1-Id4 Interaction .  nt J Biochem Cell Biol .2019 ( 116 )   2019.9 BMP9 Prevents Induction of Osteopontin in JNK-inactivated Osteoblasts via Hey1-Id4 InteractionReviewed

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  • Nahoko Eiraku , Norika Chiba , Toshiaki Nakamura , Muhammad Subhan Amir 3 , Chang-Hwan Seong 3 , Tomokazu Ohnishi , Joji Kusuyam, Kazuyuki Noguchi, Tetsuya Matsuguchi .  BMP9 Directly Induces Rapid GSK3-β Phosphorylation in a Wnt-independent Manner Through Class I PI3K-Akt Axis in Osteoblasts .  FASEB J .   2019.7BMP9 Directly Induces Rapid GSK3-β Phosphorylation in a Wnt-independent Manner Through Class I PI3K-Akt Axis in OsteoblastsReviewed

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  • Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T. .  Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. .  Cell Signal   109345   2019.6Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cellsig.2019.109345.

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  • Kusuyama J, Amir MS, Albertson BG, Bandow K, Ohnishi T, Nakamura T, Noguchi K, Shima K, Semba I, Matsuguchi T. .  JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4). .  FASEB J33 ( 6 ) 7331 - 7347   2019.6JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4).Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fj.201802465R.

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  • Kusuyama J, Nakamura T, Ohnishi T, Albertson BG, Ebe Y, Eiraku N, Noguchi K, Matsuguchi T. .  Low-intensity pulsed ultrasound promotes bone morphogenic protein 9-induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho-associated kinase 1 in human periodontal ligament fibroblasts. .  J Cell Biochem   10   2019.4Low-intensity pulsed ultrasound promotes bone morphogenic protein 9-induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho-associated kinase 1 in human periodontal ligament fibroblasts.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcb.28727.

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  • Kusuyama J, Kamisono A, ChangHwan S, Amir MS, Bandow K, Eiraku N, Ohnishi T, Matsuguchi T. .  Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities. .  J Cell Physiol233 ( 3 ) 2549 - 2559   2018.3Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities.Reviewed

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    DOI: 10.1002/jcp.26130.

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  • Kusuyama J, Ohnishi T, Bandow K, Amir MS, Shima K, Semba I, Matsuguchi T. .  Constitutive activation of p46JNK2 is indispensable for C/EBPホエ induction in the initial stage of adipogenic differentiation. .  Biochem J474 ( 20 ) 3421 - 3437   2017.10Constitutive activation of p46JNK2 is indispensable for C/EBPホエ induction in the initial stage of adipogenic differentiation.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1042/BCJ20170332.

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  • Kusuyama J, Nakamura T, Ohnishi T, Eiraku N, Noguchi K, Matsuguchi T. .  Low-Intensity Pulsed Ultrasound (LIPUS) Promotes BMP9-Induced Osteogenesis and Suppresses Inflammatory Responses in Human Periodontal Ligament-Derived Stem Cells. .  J Orthop Trauma31 ( 7 ) S4   2017.7Low-Intensity Pulsed Ultrasound (LIPUS) Promotes BMP9-Induced Osteogenesis and Suppresses Inflammatory Responses in Human Periodontal Ligament-Derived Stem Cells.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.bot.0000520897.92470.70.

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  • Kusuyama J, Bandow K, Ohnishi T, Hisadome M, Shima K, Semba I, Matsuguchi T. .  Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low-molecular weight protein tyrosine phosphatase. .  Mol Biol Cell28 ( 10 ) 1326 - 1336   2017.5Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low-molecular weight protein tyrosine phosphatase.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1091/mbc.E16-10-0716.

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  • Kusuyama J, Komorizono A, Bandow K, Ohnishi T, Matsuguchi T. .  CXCL3 positively regulates adipogenic differentiation. .  J Lipid Res57 ( 10 ) 1806 - 1820   2016.10CXCL3 positively regulates adipogenic differentiation.Reviewed

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  • Hisadome M, Ohnishi T, Kakimoto K, Kusuyama J, Bandow K, Kanekura T, Matsuguchi T. .  Hepatocyte growth factor reduces CXCL10 expression in keratinocytes. .  FEBS Lett590 ( 20 ) 3595 - 3605   2016.10Hepatocyte growth factor reduces CXCL10 expression in keratinocytes.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/1873-3468.12452.

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  • Kusuyama J, Hwan Seong C, Ohnishi T, Bandow K, Matsuguchi T. .  Low-Intensity Pulsed Ultrasound (LIPUS) Stimulation Helps to Maintain the Differentiation Potency of Mesenchymal Stem Cells by Induction in Nanog Protein Transcript Levels and Phosphorylation. .  J Orthop Trauma30 ( 8 ) S4 - S5   2016.8Low-Intensity Pulsed Ultrasound (LIPUS) Stimulation Helps to Maintain the Differentiation Potency of Mesenchymal Stem Cells by Induction in Nanog Protein Transcript Levels and Phosphorylation.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.bot.0000489983.17459.0b.

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  • Maeda A, Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Miyawaki S, Matsuguchi T. .  Induction of CXCL2 and CCL2 by pressure force requires IL-1ホイ-MyD88 axis in osteoblasts. .  Bone74   76 - 82   2015.5Induction of CXCL2 and CCL2 by pressure force requires IL-1ホイ-MyD88 axis in osteoblasts.Reviewed

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    DOI: 10.1016/j.bone.2015.01.007.

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  • Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Matsuguchi T. .  AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation. .  Bone74   125 - 133   2015.5AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation.Reviewed

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    DOI: 10.1016/j.bone.2014.12.001.

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  • Kusuyama J, Bandow K, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T. .  Low intensity pulsed ultrasound (LIPUS) influences the multilineage differentiation of mesenchymal stem and progenitor cell lines through ROCK-Cot/Tpl2-MEK-ERK signaling pathway. .  J Biol Chem289 ( 15 ) 10330 - 10344   2014.4Low intensity pulsed ultrasound (LIPUS) influences the multilineage differentiation of mesenchymal stem and progenitor cell lines through ROCK-Cot/Tpl2-MEK-ERK signaling pathway.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M113.546382.

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  • Ohnishi T, Bandow K, Kakimoto K, Kusuyama J, Matsuguchi T. .  Long-time treatment by low-dose N-acetyl-L-cysteine enhances proinflammatory cytokine expressions in LPS-stimulated macrophages. .  PLoS One9 ( 2 ) e87229   2014.2Long-time treatment by low-dose N-acetyl-L-cysteine enhances proinflammatory cytokine expressions in LPS-stimulated macrophages.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0087229.

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  • Nakao J, Fujii Y, Kusuyama J, Bandow K, Kakimoto K, Ohnishi T, Matsuguchi T. .  Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4-MyD88 dissociation. .  Bone58   17 - 25   2014.1Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4-MyD88 dissociation.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bone.2013.09.018.

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  • Matsui I, Hamano T, Mikami S, Inoue K, Shimomura A, Nagasawa Y, Michigami T, Ohnishi T, Fujii N, Nakano C, Kusunoki Y, Kitamura H, Iwatani H, Takabatake Y, Kaimori JY, Matsuba G, Okoshi K, Kimura-Suda H, Tsubakihara Y, Rakugi H, Isaka Y. .  Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats. .  Am J Physiol Renal Physiol304 ( 6 ) F751 - F760   2013.3Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajprenal.00329.2012.

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  • Bandow K, Kusuyama J, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T. .  LPS-induced chemokine expression in both MyD88-dependent and -independent manners is regulated by Cot/Tpl2-ERK axis in macrophages. .  FEBS Lett586 ( 10 ) 1540 - 1546   2012.5LPS-induced chemokine expression in both MyD88-dependent and -independent manners is regulated by Cot/Tpl2-ERK axis in macrophages.Reviewed

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    DOI: 10.1016/j.febslet.2012.04.018.

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  • Okamoto A, Ohnishi T, Bandow K, Kakimoto K, Chiba N, Maeda A, Fukunaga T, Miyawaki S, Matsuguchi T. .  Reduction of orthodontic tooth movement by experimentally induced periodontal inflammation in mice. .  Eur J Oral Sci117 ( 3 ) 238 - 247   2009.6Reduction of orthodontic tooth movement by experimentally induced periodontal inflammation in mice.Reviewed

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    DOI: 10.1111/j.1600-0722.2009.00625.x.

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  • Matsuguchi T, Chiba N, Bandow K, Kakimoto K, Masuda A, Ohnishi T. .  JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation. .  J Bone Miner Res24 ( 3 ) 398 - 410   2009.3JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation.Reviewed

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    DOI: 10.1359/jbmr.081107.

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  • Bandow K, Nishikawa Y, Ohnishi T, Kakimoto K, Soejima K, Iwabuchi S, Kuroe K, Matsuguchi T. .  Low-intensity pulsed ultrasound (LIPUS) induces RANKL, MCP-1, and MIP-1beta expression in osteoblasts through the angiotensin II type 1 receptor. .  J Cell Physiol211 ( 2 ) 392 - 398   2007.5Low-intensity pulsed ultrasound (LIPUS) induces RANKL, MCP-1, and MIP-1beta expression in osteoblasts through the angiotensin II type 1 receptor.Reviewed

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  • Bandow K, Ohnishi T, Tamura M, Semba I, Daikuhara Y. .  Hepatocyte growth factor/scatter factor stimulates migration of muscle precursors in developing mouse tongue. .  J Cell Physiol201 ( 2 ) 236 - 243   2004.11Hepatocyte growth factor/scatter factor stimulates migration of muscle precursors in developing mouse tongue.Reviewed

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  • Padalko E, Ohnishi T, Matsushita K, Sun H, Fox-Talbot K, Bao C, Baldwin WM 3rd, Lowenstein CJ .  Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry. .  Proceedings of the National Academy of Sciences of the United States of America101 ( 32 ) 11731 - 6   2004.8Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry.

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    DOI: 10.1073/pnas.0400518101

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  • Padalko E, 大西智和(OhnishiTomokazu), Matsushita K, Sun H, Fox-Talbot K, Bao C, Baldwin WM 3rd, Lowenstein CJ. .  Peroxynitrite inhibition of Coxackievirus infection by prevention of viral RNA entry. .  Proc Natl Acad Sci USA101 ( 32 ) 11731 - 11736   2004.1Peroxynitrite inhibition of Coxackievirus infection by prevention of viral RNA entry.Reviewed International coauthorship

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  • Ohnishi T, Daikuhara Y. .  Hepatocyte growth factor/scatter factor in development, inflammation and carcinogenesis: its expression and role in oral tissues. .  Arch Oral Biol48 ( 12 ) 797 - 804   2003.12Hepatocyte growth factor/scatter factor in development, inflammation and carcinogenesis: its expression and role in oral tissues.Reviewed

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  • Ohnishi Tomokazu, Daikuhara Yasushi .  口腔生物学における肝細胞増殖因子(Hepatocyte Growth Factor in Oral Biology) .  Dentistry in Japan39   48 - 51   2003.3口腔生物学における肝細胞増殖因子(Hepatocyte Growth Factor in Oral Biology)

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    Publisher:日本歯科医学会  

  • Tsuboi Y, Kakimoto K, Nakajima M, Akatsu H, Yamamoto T, Ogawa K, Ohnishi T, Daikuhara Y, Yamada T. .  Increased hepatocyte growth factor level in cerebrospinal fluid in Alzheimer's disease. .  Acta Neurol Scand107 ( 2 ) 81 - 86   2003.2Increased hepatocyte growth factor level in cerebrospinal fluid in Alzheimer's disease.Reviewed

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  • 大西智和(OhnishiTomokazu) .  Hepatocyte growth factor in oral biology .  Dentistry in Japan39 ( ※ ) 48 - 51   2003Hepatocyte growth factor in oral biology

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Ito T, Suzuki A, Imai E, Horimoto N, Ohnishi T, Daikuhara Y, Hori M. .  Tornado extraction: a method to enrich and purify RNA from the nephrogenic zone of the neonatal rat kidney. .  Kidney Int62 ( 3 ) 763 - 769   2002.9Tornado extraction: a method to enrich and purify RNA from the nephrogenic zone of the neonatal rat kidney.Reviewed

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  • Matsumori A, Takano H, Obata JE, Takeda S, Tsuyuguchi N, Ono K, Okada M, Miyamoto T, Ohnishi T, Daikuhara Y, Sasayama S. .  Circulating hepatocyte growth factor as a diagnostic marker of thrombus formation in patients with cerebral infarction. .  Circ J66 ( 2 ) 216 - 218   2002.2Circulating hepatocyte growth factor as a diagnostic marker of thrombus formation in patients with cerebral infarction.Reviewed

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  • Matsumori Akira, Takano Hajime, Obata Jun-ei, Takeda Satoshi, Tsuyuguchi Naohiko, Ono Koh, Okada Masaharu, Miyamoto Tadashi, Ohnishi Tomokazu, Daikuhara Yasushi, Sasayama Shigetake .  脳梗塞患者における血栓形成診断の標識としての血中肝細胞増殖因子(Circulating Hepatocyte Growth Factor as a Diagnostic Marker of Thrombus Formation in Patients With Cerebral Infarction) .  Circulation Journal66 ( 2 ) 216 - 218   2002.1脳梗塞患者における血栓形成診断の標識としての血中肝細胞増殖因子(Circulating Hepatocyte Growth Factor as a Diagnostic Marker of Thrombus Formation in Patients With Cerebral Infarction)

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    Publisher:(一社)日本循環器学会  

    急性心筋梗塞の超早期に血中肝細胞増殖因子(HGF)濃度が上昇することを見出したので脳梗塞の場合も血中HGFが血栓形成の標識となるか否かを検討した.脳梗塞32例中,血中HGFが対照者の平均+2SD以上を示したのは発症6時間以内で20例中10例,発症24時間以内で32例中15例であった.HGF高値の患者の約半数で血漿中D-dimerも高値であった

  • Qian Z, Gelzer-Bell R, Yang Sx SX, Cao W, Ohnishi T, Wasowska BA, Hruban RH, Rodriguez ER, Baldwin WM 3rd, Lowenstein CJ. .  Inducible nitric oxide synthase inhibition of weibel-palade body release in cardiac transplant rejection. .  Circulation104 ( 19 ) 2369 - 2375   2001.11Inducible nitric oxide synthase inhibition of weibel-palade body release in cardiac transplant rejection.Reviewed International coauthorship

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  • Ohnishi T, Kakimoto K, Hashida S, Fujii M, Hirono S, Nishiyama K, Amita Y, Ishikawa E, Tsubouchi H, Daikuhara Y. .  Development of highly sensitive enzyme-linked immunosorbent assays for hepatocyte growth factor/scatter factor (HGF/SF): determination of HGF/SF in serum and urine from normal human subjects. .  J Immunol Methods244 ( 43467 ) 163 - 173   2000.10Development of highly sensitive enzyme-linked immunosorbent assays for hepatocyte growth factor/scatter factor (HGF/SF): determination of HGF/SF in serum and urine from normal human subjects.Reviewed

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  • Matsumori A, Miyazaki S, Takano H, Ono K, Okada M, Miyamoto T, Nonogi H, Daikoku S, Mitsudo K, Matsunaga Y, Ohnishi T, Daikuhara Y, Sasayama S. .  Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris. .  Jpn Circ J64 ( 10 ) 805 - 807   2000.10Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris.Reviewed

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  • Matsumori Akira, Miyazaki Shun-ichi, Takano Hajime, Ono Koh, Okada Masaharu, Miyamoto Tadashi, Nonogi Hiroshi, Daikoku Satoshi, Mitsudo Kazuaki, Matsunaga Yoichi, Ohnishi Tomokazu, Daikuhara Yasushi, Sasayama Shigetake .  不安定狭心症における血栓形成標識としての血中肝細胞増殖因子 .  Japanese Circulation Journal64 ( 10 ) 805 - 807   2000.9不安定狭心症における血栓形成標識としての血中肝細胞増殖因子

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    Language:English   Publisher:(一社)日本循環器学会  

    新しい酵素結合免疫測定法によると10pg/mlのヒト肝細胞増殖因子(HGF)の測定が可能である.本法によると不安定狭心症患者36例の血中HGFは296±184pg/mlで健康者250例の201±64pg/mlより有意に大であった(p<0.0001).不安定狭心症36例中12例では健康者の平均+2SD,即ち321pg/ml以上の高値であった

  • Dziegielewska KM, Daikuhara Y, Ohnishi T, Waite MP, Ek J, Habgood MD, Lane MA, Potter A, Saunders NR. .  Fetuin in the developing neocortex of the rat: distribution and origin. .  J Comp Neurol423 ( 3 ) 373 - 388   2000.7Fetuin in the developing neocortex of the rat: distribution and origin.Reviewed

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  • OHNISHI T., SUWA M., OYAMA T., ARAKAKI N., TORII M., DAIKUHARA Y. .  Prostaglandin E_2 Predominantly Induces Production of Hepatocyte Growth Factor/Scatter Factor in Human Dental Pulp in Acute Inflammation .  Journal of dental research79 ( 2 ) 748 - 755   2000.2

  • Ohnishi T, Suwa M, Oyama T, Arakaki N, Torii M, Daikuhara Y. .  Prostaglandin E2 predominantly induces production of hepatocyte growth factor/scatter factor in human dental pulp in acute inflammation. .  J Dent Res79 ( 2 ) 748 - 755   2000.2Prostaglandin E2 predominantly induces production of hepatocyte growth factor/scatter factor in human dental pulp in acute inflammation.Reviewed

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  • Abdullah Abu Musa DM, Kobayashi K, Yasuda I, Iijima M, Christoffels VM, Tomomura M, Horiuchi M, Ohnishi T, Kajihara T, Daikuhara Y, Lamers WH, Saheki T. .  Involvement of a cis-acting element in the suppression of carbamoyl phosphate synthetase I gene expression in the liver of carnitine-deficient mice. .  Mol Genet Metab68 ( 3 ) 346 - 356   1999.11Involvement of a cis-acting element in the suppression of carbamoyl phosphate synthetase I gene expression in the liver of carnitine-deficient mice.Reviewed

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  • Nakamura O, Kazi JA, Ohnishi T, Arakaki N, Shao Q, Kajihara T, Daikuhara Y. .  Effects of rat fetuin on stimulation of bone resorption in the presence of parathyroid hormone. .  Biosci Biotechnol Biochem63 ( 8 ) 1383 - 1391   1999.8Effects of rat fetuin on stimulation of bone resorption in the presence of parathyroid hormone.Reviewed

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  • 中村 修, ジャミール・アハサン・カジ , 大西 智和, 新垣 尚捷, シャオ・チン , 梶原 武弘, 大工原 恭 .  副甲状腺ホルモン存在下における骨吸収促進に及ぼすラットフェチュインの効果 .  Bioscience, Biotechnology, and Biochemistry63 ( 8 ) 1383 - 1391   1999.8副甲状腺ホルモン存在下における骨吸収促進に及ぼすラットフェチュインの効果

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    ラットフェチュインは骨基質から精製された59kDaのシアロ蛋白質で,ヒトα2-HS糖蛋白質及びウシフェチュインの分子ホモログである.本蛋白質を,45Ca標識した骨片からの45Caの遊離を指標にした骨吸収系に添加したところ,本蛋白質単独では何の効果もなかったが,低濃度の副甲状腺ホルモンにより誘導される骨吸収を用量依存的に促進した.この効果は,カテプシンLの阻害剤であるキモスタチンによって阻害された.I型コラーゲンを本蛋白質とプレインキュベーションすると,カテプシンLによるI型コラーゲンの分解が用量依存的に促進された

  • Arakaki N, Kajihara T, Arakaki R, Ohnishi T, Kazi JA, Nakashima H, Daikuhara Y. .  Involvement of oxidative stress in tumor cytotoxic activity of hepatocyte growth factor/scatter factor. .  J Biol Chem274 ( 19 ) 13541 - 13546   1999.5Involvement of oxidative stress in tumor cytotoxic activity of hepatocyte growth factor/scatter factor.Reviewed

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  • Kajihara T, Ohnishi T, Arakaki N, Semba I, Daikuhara Y. .  Expression of hepatocyte growth factor/scatter factor and c-Met in human dental papilla and fibroblasts from dental papilla. .  Arch Oral Biol44 ( 2 ) 135 - 147   1999.2Expression of hepatocyte growth factor/scatter factor and c-Met in human dental papilla and fibroblasts from dental papilla.Reviewed

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    PubMed

  • Kazi JA, Nakamura O, Ohnishi T, Arakaki N, Kajihara T, Nakagawa S, Daikuhara Y. .  Changes with age of the rat fetuin concentration in serum and its mRNA expression. .  J Biochem124 ( 1 ) 179 - 186   1998.7Changes with age of the rat fetuin concentration in serum and its mRNA expression.Reviewed

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  • Arakaki N, Kazi JA, Kazihara T, Ohnishi T, Daikuhara Y. .  Hepatocyte growth factor/scatter factor activates the apoptosis signaling pathway by increasing caspase-3 activity in sarcoma 180 cells. .  Biochem Biophys Res Commun245 ( 1 ) 211 - 215   1998.4Hepatocyte growth factor/scatter factor activates the apoptosis signaling pathway by increasing caspase-3 activity in sarcoma 180 cells.Reviewed

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  • Ohnishi T, Nakamura O, Arakaki N, Daikuhara Y. .  Effect of phosphorylated rat fetuin on the growth of hepatocytes in primary culture in the presence of human hepatocyte-growth factor. Evidence that phosphorylated fetuin is a natural modulator of hepatocyte-growth factor. .  Eur J Biochem243 ( 3 ) 753 - 761   1997.2Effect of phosphorylated rat fetuin on the growth of hepatocytes in primary culture in the presence of human hepatocyte-growth factor. Evidence that phosphorylated fetuin is a natural modulator of hepatocyte-growth factor.Reviewed

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  • Shao Q, Arakaki N, Ohnishi T, Nakamura O, Daikuhara Y. .  Effect of hepatocyte growth factor/scatter factor on lipogenesis in adult rat hepatocytes in primary culture. .  J Biochem119 ( 5 ) 940 - 946   1996.5Effect of hepatocyte growth factor/scatter factor on lipogenesis in adult rat hepatocytes in primary culture.Reviewed

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  • Sugiyama A, Arakaki R, Ohnishi T, Arakaki N, Daikuhara Y, Takada H. .  Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture. .  Infect Immun64 ( 4 ) 1426 - 1431   1996.4Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture.Reviewed

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  • Arakaki N, Kawakami S, Nakamura O, Ohnishi T, Miyazaki H, Ishii T, Tsubouchi H, Daikuhara Y. .  Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases. .  Hepatology22 ( 6 ) 1728 - 1734   1995.12Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases.Reviewed

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  • Ohnishi T, Nakamura O, Arakaki N, Miyazaki H, Daikuhara Y. .  Effects of cytokines and growth factors on phosphorylated fetuin biosynthesis by adult rat hepatocytes in primary culture. .  Biochem Biophys Res Commun200 ( 1 ) 598 - 605   1994.4Effects of cytokines and growth factors on phosphorylated fetuin biosynthesis by adult rat hepatocytes in primary culture.Reviewed

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  • Ohnishi T, Nakamura O, Ozawa M, Arakaki N, Muramatsu T, Daikuhara Y. .  Molecular cloning and sequence analysis of cDNA for a 59 kD bone sialoprotein of the rat: demonstration that it is a counterpart of human alpha 2-HS glycoprotein and bovine fetuin. .  J Bone Miner Res8 ( 3 ) 367 - 377   1993.3Molecular cloning and sequence analysis of cDNA for a 59 kD bone sialoprotein of the rat: demonstration that it is a counterpart of human alpha 2-HS glycoprotein and bovine fetuin.Reviewed

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  • Ohnishi T, Arakaki N, Nakamura O, Hirono S, Daikuhara Y. .  Purification, characterization, and studies on biosynthesis of a 59-kDa bone sialic acid-containing protein (BSP) from rat mandible using a monoclonal antibody. Evidence that 59-kDa BSP may be the rat counterpart of human alpha 2-HS glycoprotein and is synthesized by both hepatocytes and osteoblasts... .  J Biol Chem266 ( 22 ) 14636 - 14645   1991.8Purification, characterization, and studies on biosynthesis of a 59-kDa bone sialic acid-containing protein (BSP) from rat mandible using a monoclonal antibody. Evidence that 59-kDa BSP may be the rat counterpart of human alpha 2-HS glycoprotein and is synthesized by both hepatocytes and osteoblasts...Reviewed

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  • 27. S. Kumasa, H. Mori, M. Mori, T. Shibutani, Y. Iwayama, T. Tsujimura, T. Ohnishi, N. Arakaki, M. Nakata, K. Kurisu. .  Heterotopic bone formation in tumor stroma tissue .  Acta Histochim Cytochim23   427 - 439   1990.11Heterotopic bone formation in tumor stroma tissueReviewed

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  • KUMASA SHUNSUKE, MORI HIROMITSU, MORI MASAHIKO, SHIBUTANI TOSHIAKI, IWAYAMA YUKIO, TSUJIMURA TAKAHIRO, OHNISHI TOMOKAZU, ARAKAKI NAOKATSU, NAKATA MINORU, KURISU KOJIRO .  Heterotopic bone formation in tumor stromal tissue. Immunohistochemical considerations. .  ACTA HISTOCHEMICA ET CYTOCHEMICA23 ( 4 ) 427 - 439   1990

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    Language:English   Publisher:JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY  

    Ectopic and heterotopic bone formation rarely occur in stromal tissues of various epithelial tumors. In the present study, ectopic bone forming tumors; calcifying epithelioma Malherbe (6), renal cell carcinoma (1), thyroid adenocarcinoma (1) and ovary carcinoma (1) were examined. The process of ectopic bone formation could be classified into 1) bone formation related to epithelial tissue as found in calcifying epithelioma of Malherbe, 2) bone formation from perivascular smooth muscle, and 3) that due to metaplasia occurring in stromal connective tissue of epithelial tumors. Immunohistochemical detection of proteoglycans (PG) was made in bone-forming matrix areas, and these areas were positive for chondrotin 4 and 6 sulfate, and dermatan and heparan sulfate PGs. Immunohistochemically, fibronectin, collagen III and bone sialoprotein as matrix proteins, and carbonic anhydrase as calcification marker were tested and they appeared in these pre-calcifying tissues.

    DOI: 10.1267/ahc.23.427

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Books

  • Nitric oxide and myocarditis

    Nitric oxide and Inflammation,Birkhäuser Verlag  2001 

  • α2- HS 糖タンパク質 ヒトフェチュイン

    血漿タンパク質・廣川書店  2001 

MISC

  • 【HGF-発見とその展開】HGFの構造と機能

    大西 智和, 大工原 恭

    肝胆膵   38 ( 4 )   613 - 621   1999.4

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    Publisher:(株)アークメディア  

  • HGFの構造と機能

    肝胆膵   38   613 - 622   1999

Presentations

  • Ohnishi T.   Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation  

    Biochemical Journal  2020.5  Biochemical Journal

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  • 竹川 政範, 佐藤 泰祥, 本橋 征之, 吉田 将亜, 藤盛 真樹, 谷 和俊, 大西 智和, 松田 光悦   骨髄由来の間葉系幹細胞を用いた骨再生に使用する担体の評価  

    日本口腔科学会雑誌  2008.1  (NPO)日本口腔科学会

  • 大西 智和, 楠山 譲二, 坂東 健二郎, 柿元 協子, 松口 徹也   骨芽細胞分化によるATP産生経路の呼吸鎖から解糖系への移行  

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集  2015.12  (公社)日本生化学会

  • 葛西 貴行, 坂東 健二郎, 柿本 協子, 大西 智和, 川本 真一郎, 長岡 英一, 松口 徹也   骨芽細胞分化における細胞内エネルギーセンサーキナーゼ(AMPK)の役割  

    Journal of Oral Biosciences  2009.8  (一社)歯科基礎医学会

  • 松口 徹也, 坂東 健二郎, 柿元 協子, 大西 智和   骨芽細胞分化におけるJNKの役割  

    Journal of Oral Biosciences  2007.8  (一社)歯科基礎医学会

  • 楠山 譲二, 坂東 健二郎, 柿元 協子, 大西 智和, 松口 徹也   骨芽細胞におけるCot/Tpl2を介したメカニカルストレスのシグナル伝達経路  

    Journal of Oral Biosciences  2011.9  (一社)歯科基礎医学会

  • 大西 智和, 千葉 紀香, 松口 徹也   解糖阻害は初期分化段階の初代骨芽細胞においてユビキチン-プロテアソーム系を介してアポトーシスタンパク質の発現を増加させる  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 大西 智和, 楠山 讓二, Subhan Amir, 榮樂 菜保子, 松口 徹也   解糖系阻害が骨芽細胞のユビキチン-プロテアソーム機構に及ぼす影響  

    生命科学系学会合同年次大会  2017.12  生命科学系学会合同年次大会運営事務局

  • Hisadome Mitsuhiro, Ohnishi Tomokazu, Kakimoto Kyoko, Kusuyama Joji, Bandow Kenjiro, Kanekura Takuro, Matsuguchi Tetsuya   角化細胞において肝細胞増殖因子はCXCL10の発現を減少させる(Hepatocyte growth factor reduces CXCL10 expression in keratinocytes)  

    日本研究皮膚科学会年次学術大会・総会プログラム  2016.12  (一社)日本研究皮膚科学会

  • 岩谷 博次, 長澤 康行, 上田 仁康, 山本 陵平, 新澤 真紀, 大西 智和, 松口 徹也, 楽木 宏実, 猪阪 善隆   腎糸球体IgA沈着にはTLR9刺激ではなく、微生物学的環境が関与する  

    日本腎臓学会誌  2012.4  (一社)日本腎臓学会

  • 坂東 健二郎, 田村 正人, 大西 智和, 仙波 伊知郎, 大工原 恭   胎生期のマウス舌における肝細胞増殖因子(HGF)の生理活性  

    歯科基礎医学会雑誌  2001.8  (一社)歯科基礎医学会

  • 大西 智和, 町頭 三保, 坂東 健二郎, 楠山 譲二, 柿元 協子, 松口 徹也   結紮誘導歯周炎モデルにおけるP.gingivalis感染が糖尿病マウスに及ぼす影響  

    Journal of Oral Biosciences  2011.9  (一社)歯科基礎医学会

  • 長澤 康行, 大西 智和, 橋本 雅仁, 川田 早百合, 永井 孝憲, 木田 有利, 名波 正義, 蓮池 由起子, 倉賀野 隆裕, 中西 健   細菌感染のよるIgA腎症モデルマウスの作成の検討  

    日本腎臓学会誌  2015.4  (一社)日本腎臓学会

  • 大西 智和, 柿元 協子, 坂東 健二郎, 町頭 三保, 松口 徹也   糖尿病モデルマウスにおける歯槽骨吸収とeNOS発現  

    Journal of Oral Biosciences  2005.9  (一社)歯科基礎医学会

  • 坂東 健二郎, 大西 智和, 田村 正人, 大工原 恭   筋芽細胞におけるHGFとbFGFの作用  

    歯科基礎医学会雑誌  2003.9  (一社)歯科基礎医学会

  • 大西 智和   石灰化組織に見いだされるフェチュイン  

    Connective Tissue  1993.6  日本結合組織学会

  • 坂東 健二郎, 田村 正人, 大西 智和, 仙波 伊知郎, 大工原 恭   発生期の舌におけるHGF/SFの生理活性  

    生化学  2000.8  (公社)日本生化学会

  • 坂東 健二郎, 大西 智和, 仙波 伊知郎, 大工原 恭   発生期の培養マウス舌における肝細胞増殖因子(HGF)の発現  

    歯科基礎医学会雑誌  1999.8  (一社)歯科基礎医学会

  • 大西 智和, 新垣 尚捷, 鳥井 光男, 大工原 恭   炎症歯髄における肝細胞増殖因子(HGF)の産生促進機構  

    歯科基礎医学会雑誌  1998.9  (一社)歯科基礎医学会

  • 柿元 協子, 町頭 三保, 大西 智和, 梶原 武弘, 仙波 伊知郎, 瀬戸口 尚志, 田村 正人, 和泉 雄一, 大工原 恭   歯周疾患患者における歯肉溝滲出液中のHGF濃度の測定  

    生化学  2001.8  (公社)日本生化学会

  • 柿元 協子, 町頭 三保, 大西 智和, 梶原 武弘, 仙波 伊知郎, 田村 正人, 大工原 恭   歯周炎患者における歯肉中HGFの動態  

    歯科基礎医学会雑誌  2002.9  (一社)歯科基礎医学会

  • 岡本 敦子, 大西 智和, 福永 智広, 前田 綾, 宮脇 正一, 松口 徹也   歯周炎モデルマウスにおける矯正的歯の移動度の減弱  

    日本矯正歯科学会大会プログラム・抄録集  2008.9  (公社)日本矯正歯科学会

  • 大西 智和, 柿元 協子, 坂東 健二郎, 松口 徹也   実験的歯周炎における歯槽骨吸収のCot/Tpl2による制御  

    日本骨代謝学会学術集会プログラム抄録集  2008.10  (一社)日本骨代謝学会

  • 大西 智和, 松口 徹也   基礎系科目の学習効果向上に有効であった授業方法  

    日本歯科医学教育学会総会・学術大会プログラム・抄録集  2015.7  (一社)日本歯科医学教育学会

  • 大西 智和   卵黄抗体(IgY)を用いたhHGFの高感度測定法の開発  

    生化学  1997.7  (公社)日本生化学会

  • 大西 智和   初代培養肝細胞におけるラット下顎骨由来59kDaのリン酸不含シアロタンパク質の生合成調節  

    生化学  1992.8  (公社)日本生化学会

  • 松口 徹也, 千葉 紀香, 成 昌奐, 大西 智和   低酸素誘導因子Hif-1α蛋白は骨芽細胞のBMP9刺激により早期に誘導され、解糖系酵素PDK1の発現を介して骨芽細胞分化に重要な役割を果たす  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • Kusuyama Joji, Nakamura Toshiaki, Ohnishi Tomokazu, Eiraku Nahoko, Noguchi Kazuyuki, Matsuguchi Tetsuya   低出力超音波パルス(LIPUS)は、ヒト歯根膜由来幹細胞(hPDLSCs)におけるBMP9誘導骨形成を促進し、炎症応答を抑制する(LOW intensity pulsed ultrasound(LIPUS) promotes BMP9-induced osteogenesis and suppresses inflammatory responses in human periodontal ligament-derived stem cells(hPDLSCs))  

    Journal of Hard Tissue Biology  2016.10  硬組織再生生物学会

  • 大西 智和   リン酸化ラットfetuinの肝細胞増殖因子に対する効果  

    生化学  1993.8  (公社)日本生化学会

  • 大西 智和   ラット骨由来シアロタンパク質の骨芽細胞による生合成  

    生化学  1990.7  (公社)日本生化学会

  • 大西 智和   ラット骨由来シアロタンパク質の産生細胞  

    歯科基礎医学会雑誌  1990.9  (一社)歯科基礎医学会

  • 大西 智和   ラット下顎骨由来59kDaシアロタンパク質(59-kDa BSP)の分子クローニングと発現調節機構  

    歯科基礎医学会雑誌  1992.9  (一社)歯科基礎医学会

  • 大西 智和   ラット下顎骨由来59-kDaリン酸不含シアロタンパク質(59-kDa BSP)をコードするcDNAのクローニングとその解析  

    日本骨代謝学会雑誌  1992.6  (一社)日本骨代謝学会

  • 大西 智和   ラット下顎骨から精製したシアロタンパク(59-KDa BSP)の性質と生合成  

    歯科基礎医学会雑誌  1993.9  (一社)歯科基礎医学会

  • 大西 智和, 坂東 健二郎, 柿元 協子, 大工原 恭   ラットfetuinとIgGのFc部分との結合  

    歯科基礎医学会雑誌  2003.9  (一社)歯科基礎医学会

  • 大西 智和, 柿元 協子, 坂東 健二郎, 松口 徹也   メタボリックインドロームを持つ2型糖尿病モデルマウスの歯槽骨吸収に酸化的ストレスが及ぼす影響  

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集  2007.11  (公社)日本生化学会

  • 坂東 健二郎, 楠山 譲二, 柿元 協子, 大西 智和, 松口 徹也   マクロファージにおけるLPSによるCot/Tpl2-ERK経路を介したケモカインの誘導  

    Journal of Oral Biosciences Supplement  2012.9  (一社)歯科基礎医学会

  • 大西 智和, 坂東 健二郎, 柿元 協子, 楠山 譲二, 松口 徹也   マウス頭蓋冠由来骨芽細胞の分化と解糖系の関係  

    日本骨代謝学会学術集会プログラム抄録集  2013.5  (一社)日本骨代謝学会

  • 大西 智和, 千葉 紀香, 松口 徹也, 久留 光博, 榮樂 菜保子, スバン・アミル   ケラチノサイトにおける紫外線B波長によるインターフェロンγ反応性の阻害はERストレスを介する  

    日本生化学会大会プログラム・講演要旨集  2018.9  (公社)日本生化学会

  • 梶原 武弘, 大西 智和, 新垣 尚捷, 田村 正人, 大工原 恭   STAT1を介する肝細胞増殖因子(HGF)のp21発現制御機構  

    生化学  1999.8  (公社)日本生化学会

  • Ohnishi T.   Prostaglandin E<inf>2</inf> predominantly induces production of hepatocyte growth factor/scatter factor in human dental pulp in acute inflammation  

    Journal of Dental Research  2000  Journal of Dental Research

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  • 楠山 譲二, 坂東 健二郎, 大西 智和, 仙波 伊知郎, 松口 徹也   p46JNK2の構成的活性は脂肪分化前期におけるC/EBPδの発現に必須である  

    Journal of Oral Biosciences Supplement  2015.9  (一社)歯科基礎医学会

  • 成 昌奐, 大西 智和, 千葉 紀香, 松口 徹也   Notchエフェクター分子Hes1のBMP9誘導性骨芽細胞分化における発現機構および機能的意義の解明(Elucidation of molecular mechanisms and functional roles of Notch signaling molecule Hes1 in BMP9-induced osteoblast differentiation)  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • Ohnishi T.   Molecular cloning and sequence analysis of cDNA for a 59 kD bone sialoprotein of the rat: Demonstration that it is a counterpart of human α<inf>2</inf>‐HS glycoprotein and bovine fetuin  

    Journal of Bone and Mineral Research  1993.3  Journal of Bone and Mineral Research

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  • 柿元 協子, 楠山 譲二, 坂東 健二郎, 大西 智和, 松口 徹也   MAP3K8/Cot/Tpl2シグナル分子はマクロファージのLPS刺激による分解の後、NF-κBによるmRNAの誘導により回復する  

    Journal of Oral Biosciences Supplement  2015.9  (一社)歯科基礎医学会

  • Kakimoto Kyoko, Bandow Kenjiro, Kusuyama Joji, Hisadome Mitsuhiro, Ohnishi Tomokazu, Matsuguchi Tetsuya   LPS誘発性IL-12p40 mRNAはマクロファージにおいてCot/Tpl2-MEK-ERK axisを介したMCPIP-1 ribonucleaseの発現により調節される(LPS-induced IL-12p40 mRNA is regulated by MCPIP-1 ribonuclease expression through Cot/Tpl2-MEK-ERK axis in macrophages)  

    日本生化学会大会プログラム・講演要旨集  2013.9  (公社)日本生化学会

  • 松口 徹也, 楠山 譲二, 坂東 健二郎, 柿元 協子, 大西 智和   Low-Intensity Pulsed Ultra Sound(LIPUS)が炎症性遺伝子発現に及ぼす影響  

    Journal of Oral Biosciences Supplement  2012.9  (一社)歯科基礎医学会

  • Nakamura M.   Long-term result of combination of open reduction and femoral derotation varus osteotomy with shortening for developmental dislocation of the hip  

    Journal of Pediatric Orthopaedics Part B  2004.7  Journal of Pediatric Orthopaedics Part B

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  • 楠山 譲二, 坂東 健二郎, 社本 光央, 柿元 協子, 大西 智和, 松口 徹也   LIPUS(低出力超音波)刺激は間葉系前駆細胞の分化方向性に影響する  

    日本生体電気・物理刺激研究会誌  2012.12  日本生体電気・物理刺激研究会

  • 楠山 譲二, 成 昌奐, 大西 智和, 嶋 香織, 仙波 伊知郎, 松口 徹也   JNK活性の減弱は正常な骨芽細胞分化を阻害し、転写因子Id4を介してオステオポンチン高発現細胞を誘導する  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • Usuki F.   Inhibition of Nonsense-Mediated mRNA Decay Rescues the Phenotype in Ullrich's Disease  

    Annals of Neurology  2004.5  Annals of Neurology

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  • 新垣 尚捷, 梶原 武弘, 大西 智和, 大工原 恭   HGFによるSarcoma 180細胞の増殖抑制機構  

    生化学  1998.8  (公社)日本生化学会

  • 久留 光博, 大西 智和, 柿元 協子, 楠山 譲二, 坂東 健二郎, 金蔵 拓郎, 松口 徹也   Hepatocyte growth factorはケラチノサイトにおいてCXCL10発現を抑制する(Hepatocyte growth factor reduces CXCL10 expression in keratinocytes)  

    西日本皮膚科  2017.8  日本皮膚科学会-西部支部

  • 大西 智和   Heat shockに関するラットfetuinプロモーター領域の解析  

    生化学  1996.7  (公社)日本生化学会

  • 楠山 譲二, 坂東 健二郎, 柿元 協子, 大西 智和, 松口 徹也   CXCL3は脂肪細胞分化を正に制御する  

    Journal of Oral Biosciences Supplement  2013.9  (一社)歯科基礎医学会

  • Ohnishi T.   Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia  

    EMBO Molecular Medicine  2021.4  EMBO Molecular Medicine

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  • Hosokawa K.   Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: An in vitro flow chamber model  

    PLoS ONE  2014.1  PLoS ONE

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  • Seong C.H.   Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts  

    FEBS Letters  2021.2  FEBS Letters

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  • 成 昌奐, 大西 智和, 千葉 紀香, 松口 徹也   BMP9誘導性骨芽細胞分化におけるNotchエフェクター分子Hes1の発現機構および機能的意義の解明(Bone morphogenetic protein 9(BMP 9) induces the expression of Hes1 in osteoblasts: Analyses of its molecular mechanisms and functional roles)  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • 松口 徹也, 千葉 紀香, 成 昌奐, 大西 智和   BMP9刺激によって誘導されるHif-1αは解糖系酵素PDK1の発現を介して骨芽細胞分化に必須の役割を果たす  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 松口 徹也, 榮樂 奈保子, 楠山 譲二, 大西 智和   BMP9はWnt非依存的に骨芽細胞のGSK3β/β-cateninシグナルを活性化する  

    Journal of Oral Biosciences Supplement  2016.9  (一社)歯科基礎医学会

  • 松口 徹也, 千葉 紀香, 楠山 譲二, 大西 智和   BMP9の骨芽細胞分化誘導作用におけるPI3K-Akt-GSK3β/β-cateninシグナル経路の重要性  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 榮樂 菜保子, 千葉 紀香, 大西 智和, 中村 利明, 松口 徹也, 野口 和行   BMP9のClass1 PI3K-Akt経路を介した直接的な骨芽細胞分化誘導  

    日本歯周病学会会誌  2019.10  (NPO)日本歯周病学会

  • 千葉 紀香, 成 昌奐, 大西 智和, 松口 徹也   BMP-9骨分化誘導シグナル伝達における転写因子Egr-1の重要な役割  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • 千葉 紀香, 大西 智和, 松口 徹也   BMP-9による骨芽細胞分化におけるEgr-1の役割の解析  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 大西 智和, 成 昌奐, 千葉 紀香, 松口 徹也   All-transレチノイン酸はHes1を介して骨芽細胞のTnfrsf11b mRNA発現低下を誘導する  

    日本生化学会大会プログラム・講演要旨集  2020.9  (公社)日本生化学会

  • Takahashi A.   <inf>P</inf>53-dependent adaptive responses in human cells exposed to space radiations  

    International Journal of Radiation Oncology Biology Physics  2010.11  International Journal of Radiation Oncology Biology Physics

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  • 松口 徹也, 千葉 紀香, 大西 智和   BMP9はPI3K-Aktシグナル経路を介して骨芽細胞のHIF-1α蛋白発現を誘導する(BMP9 induces HIF-1A protein expression in osteoblasts through PI3K-Akt axis)  

    Journal of Oral Biosciences Supplement  2021.10  (一社)歯科基礎医学会

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    Language:Japanese  

  • 松口 徹也, 楠山 譲二, 坂東 健二郎, 柿元 協子, 大西 智和   MAPキナーゼフォスファターゼ(DUSP)mRNAの不安定性による細胞ストレス反応の調節機構  

    Journal of Oral Biosciences Supplement  2013.9  (一社)歯科基礎医学会

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    Language:Japanese  

  • 大西 智和, 坂東 健二郎, 柿元 協子, 楠山 譲二, 松口 徹也   N-アセチルシステインによる活性化マクロファージにおける炎症性サイトカインの発現上昇作用  

    日本生化学会大会プログラム・講演要旨集  2012.12  (公社)日本生化学会

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    Language:Japanese  

  • 大西 智和, 松口 徹也   グループ学習及び個別学習における性格の違いの重要性  

    日本歯科医学教育学会総会・学術大会プログラム・抄録集  2017.7  (一社)日本歯科医学教育学会

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    Language:Japanese  

  • 松口 徹也, 楠山 譲二, 柿元 協子, 大西 智和   上皮細胞におけるTLR7を介した免疫制御機能の解析  

    Journal of Oral Biosciences Supplement  2015.9  (一社)歯科基礎医学会

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    Language:Japanese  

  • 大東 哲也, 竹川 政範, 原田 広文, 佐藤 泰祥, 大西 智和, 松田 光悦   上顎正中過剰埋伏歯が口蓋後方に移動した1例  

    日本口腔外科学会雑誌  2006.7  (公社)日本口腔外科学会

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    Language:Japanese  

  • 大西 智和, 柿元 協子, 梶原 武弘, 大工原 恭   末梢血中における肝細胞増殖因子(HGF)の担体  

    生化学  2002.8  (公社)日本生化学会

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    Language:Japanese  

  • Kakimoto Kyoko, Ohnishi Tomokazu, Bandow Kenjiro, Indo Hiroko, Majima Hideyuki, Daikuhara Yasushi   顆粒細胞のHGF結合分子(HGF-binding molecule on glanulocytes)  

    生化学  2003.8  (公社)日本生化学会

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    Language:English  

  • 千葉 紀香, 成 昌奐, 大西 智和, 松口 徹也   骨芽細胞分化におけるHypoxiaが及ぼす影響の解析(Hypoxia affects osteoblast differentiation)  

    Journal of Oral Biosciences Supplement  2021.10  (一社)歯科基礎医学会

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    Language:Japanese  

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Awards

  • 第9回歯科基礎医学会 ベストペーパー賞

    2023.5   歯科基礎医学会  

    大西智和

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    Award type:Honored in official journal of a scientific society, scientific journal 

  • 第4回歯科基礎医学会賞

    1994.10   歯科基礎医学会   ラット下顎骨から精製した59KDaシアロタンパク (59-KDa BSP) の性質と生合成

    大西 智和

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    Country:Japan

Research Projects

  • アイソフォーム特異的な新たなJNKシグナル制御機構の解明

    Grant number:17K11646  2021.4 - 2024.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • 歯周病菌が関わる糖尿病性腎症発症メカニズムの解明

    Grant number:20K09909  2020.4 - 2023.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

  • 抗アレルギー治療新規ターゲット分子としてのMAPキナーゼフォスファターゼの解析

    Grant number:18K09508  2018.4 - 2021.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • 歯周炎における調節性T細胞のシグナル伝達

    Grant number:17K11676  2017.4 - 2020.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  • 細胞分化コントロールによる新たな骨疾患治療法開発を目指す基礎研究

    Grant number:26462817  2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • 歯周病増悪因子Cot/Tpl2を分子標的とした治療法を探る

    Grant number:25462895  2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • LPSで誘導される高OPN骨芽細胞の骨免疫学的解析

    Grant number:23592739  2011.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Grant type:Competitive

  • ヘルパーT細胞の異常が引き起こす肥満の病態解析

    Grant number:23592740  2011.4 - 2014.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

  • 免疫監視システム制御に関わる新規シグナル分子機構の解明

    Grant number:23592741  2011.4 - 2014.3

    科学研究費補助金 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • 骨代謝に対する組織レニン‐アンギオテンシン系の影響

    Grant number:19390474  2007.4 - 2009.3

    科学研究費補助金 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • 骨芽細胞の免疫調節機能に及ぼす細胞分化とメカニカルストレスの影響

    Grant number:19390474  2007.4 - 2009.3

    科学研究費補助金 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • MAPキナーゼフォスファターゼによる生体内ヘルパーT細胞分化調節の分子機構

    Grant number:17390496  2005.4 - 2007.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • TLR-4を介するシグナル伝達系の口腔癌発生への関与

    Grant number:17591943  2005.4 - 2007.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

  • 歯周炎における肝細胞増殖因子(HGF)と一酸化窒素(NO)の血管新生作用

    Grant number:14571767  2002.4 - 2004.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

  • 肝細胞増殖因子の舌癌増殖抑制におけるシグナル伝達系の解析

    Grant number:11771142  1999.4 - 2001.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

  • 骨芽細胞分化におけるオステオカルシンmRNAのUTRに結合する因子とその作用機構

    Grant number:11671847  1999.4 - 2001.3

    科学研究費補助金  基盤研究(C)

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    Grant type:Competitive

  • 尿中HGF測定による泌尿器系腫瘍の早期診断法の開発

    Grant number:11140261  1999.4 - 2000.3

    科学研究費補助金  特定領域研究(A)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • Fetuin/α_2-HS糖タンパク質結合因子の同定

    Grant number:9771544  1997.4 - 1999.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

  • 歯周疾患の新しい診断法の開発 ー歯肉溝滲出液中のhHGFの動態と病態の検討ー

    Grant number:8557100  1996.4 - 1999.3

    科学研究費補助金  基盤研究(A)

  • 乳歯交換期の破歯細胞に及ぼすヒト肝細胞増殖因子(hHGF)の作用

    Grant number:8771614  1996.4 - 1997.3

    科学研究費補助金  奨励研究(A)

  • ヒト菌敗間葉系における肝細胞増殖因子(HGF)産生細胞の変遷

    Grant number:7771666  1995.4 - 1996.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

  • ヒト歯胚における肝細胞増殖因子(HGF)の発現とその役割

    Grant number:6857142  1994.4 - 1995.3

    科学研究費補助金  奨励研究(A)

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    Authorship:Principal investigator  Grant type:Competitive

  • ヒト肝細胞増殖因子(hHGF)の活性化及び不活性化機構-病態との関連-

    Grant number:6281252  1994.4 - 1995.3

    科学研究費補助金  重点領域研究

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • ラット骨基質由来59-KDaシアロタンパクの組換え体作製

    Grant number:5771522  1993.4 - 1994.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

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