Life Science / Bioorganic chemistry

国立国際医療センター   研究所   流動研究員

2000.4 - 2000.9

学術振興会（大阪大学）   特別研究員

1997.4 - 2000.3

日本生化学会

1996.10

日本化学会

1992.10

Thierry Devanthéry, Keisuke Nakamura, Shuhei Hashiguchi, Masahito Hashimoto .  Structure of a heptose-containing polysaccharide derived from Komagataeibacter europaeus NBRC 3261 .  Carbohydrate Research492 ( 107989 ) 1 - 4   2020.6Structure of a heptose-containing polysaccharide derived from Komagataeibacter europaeus NBRC 3261Reviewed

Takeda Y, Azuma M, Hatsugai R, Fujimoto Y, Hashimoto M, Fukase K, Matsumoto M, Seya T .  The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cells .  Innate Immunity24 ( 5 ) 323 - 331   2018.7The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cellsReviewed

Hashimoto M, Matsumoto T, Tamura-Nakano M, Ozono M, Hashiguchi S, Suda Y. .  Characterization of outer membrane vesicles of Acetobacter pasteurianus NBRC3283 .  J. Biosci. Bioeng.125 ( 4 ) 425 - 431   2018.4Characterization of outer membrane vesicles of Acetobacter pasteurianus NBRC3283 Reviewed

2. Hasibul K, Nakayama-Imaohji H, Hashimoto M, Yamasaki H, Ogawa T, Waki J, Tada A, Yoneda S, Tokuda M, Miyake M, Kuwahara T. .  D-tagatose inhibits the growth and biofilm formation of Streptococcus mutans. .  Mol Med Rep17   843 - 851   2018.1D-tagatose inhibits the growth and biofilm formation of Streptococcus mutans.Reviewed

1. Hashimoto M, Satou R, Ozono M, Inagawa H, Soma G-i .  Characterization of the O-antigen polysaccharide derived from Pantoea agglomerans IG1 lipopolysaccharide. .  Carbohydr. Res.449   32 - 36   2017.6Characterization of the O-antigen polysaccharide derived from Pantoea agglomerans IG1 lipopolysaccharide.Reviewed

2. Hashimoto M, Waki J, Nakayama-Imaohji H, Ozono M, Hashiguchi S, Kuwahara T. .  TLR2-stimulating contaminants in glycoconjugate fractions prepared from Bacteroides fragilis. .  Innate Immun.23 ( 5 ) 449 - 458   2017.5TLR2-stimulating contaminants in glycoconjugate fractions prepared from Bacteroides fragilis.Reviewed

Hashimoto M, Mizukami M, Osuki KI, Fujiwara N, Suda Y, Uchiumi T. .  Characterization of O-antigen polysaccharide backbone derived from nitric oxide-inducing Mesorhizobium loti MAFF 303099 lipopolysaccharide. .  Carbohydr. Res.445   44 - 50   2017.4Characterization of O-antigen polysaccharide backbone derived from nitric oxide-inducing Mesorhizobium loti MAFF 303099 lipopolysaccharide.Reviewed

Kino Y, Nakayama-Imaohji H, Fujita M, Tada A, Yoneda S, Murakami K, Hashimoto M, Hayashi T, Okazaki K, Kuwahara T .  Counterselection employing mutated pheS for markerless genetic deletion in Bacteroides species. .  Anaerobe42   81 - 88   2016.12Counterselection employing mutated pheS for markerless genetic deletion in Bacteroides species.Reviewed

Hashimoto M, Ozono M, Furuyashiki M, Baba R, Hashiguchi S, Suda Y, Fukase K, Fujimoto Y. .  Characterization of a novel D-glycero-D-talo-oct-2-ulosonic acid-substituted lipid a moiety in the lipopolysaccharide produced by the acetic acid bacterium Acetobacter pasteurianus NBRC 3283. .  J. Biol. Chem. 291 ( 40 ) 21184 - 21194   2016.9Characterization of a novel D-glycero-D-talo-oct-2-ulosonic acid-substituted lipid a moiety in the lipopolysaccharide produced by the acetic acid bacterium Acetobacter pasteurianus NBRC 3283.Reviewed

Watanabe S, Matsumura K, Iwai H, Funatogawa K, Haishima Y, Fukui C, Okumura K, Kato-Miyazawa M, Hashimoto M, Teramoto K, Kirikae F, Miyoshi-Akiyama T, Kirikae T. .  A Mutation in the 16S rRNA Decoding Region Attenuates the Virulence of Mycobacterium tuberculosis. .  Infect. Immun.84 ( 8 ) 2264 - 2273   2016.7A Mutation in the 16S rRNA Decoding Region Attenuates the Virulence of Mycobacterium tuberculosis.Reviewed

Hashimoto M, Obara K, Ozono M, Furuyashiki M, Ikeda T, Suda Y, Fukase K, Fujimoto Y, Shigehisa H .  Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu). .  J. Biosci. Bioeng.116 ( 6 ) 688 - 696   2013.12Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu).Reviewed

Fujimoto Y, Mitsunobe K, Fujiwara S, Mori M, Hashimoto M, Suda Y, Kusumoto S, Fukase K. .  Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus. .  Org. Biomol. Chem. 11 ( 30 ) 5034 - 5041   2013.8Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus.Reviewed

Kukita K, Kawada-Matsuo M, Oho T, Nagatomo M, Oogai Y, Hashimoto M, Suda Y, Tanaka T, Komatsuzawa H. .  Staphylococcus aureus SasA is responsible for binding to salivary agglutinin, gp340, derived from human saliva. .  Infect. Immun. 81 ( 6 ) 1870 - 1879   2013.6Staphylococcus aureus SasA is responsible for binding to salivary agglutinin, gp340, derived from human saliva.Reviewed

Hashimoto M, Eguchi H, Tawaratsumida K, Kirikae T, Suda Y .  Identification of a Toll-like receptor 2-stimulating lipoprotein in Bacteroides fragilis JCM 11019 (NCTC 9343). .  Innate Immun.19 ( 2 ) 132 - 139   2013.4Identification of a Toll-like receptor 2-stimulating lipoprotein in Bacteroides fragilis JCM 11019 (NCTC 9343).Reviewed

Hashimoto M, Tanishita Y, Suda Y, Murakami Ei, Nagata M, Kucho Ki, Abe M, Uchiumi T .  Characterization of Nitric Oxide-Inducing Lipid A derived from Mesorhizobium loti Lipopolysaccharide .  Microbes Environ.27 ( 4 ) 490 - 496   2012.12Characterization of Nitric Oxide-Inducing Lipid A derived from Mesorhizobium loti LipopolysaccharideReviewed

Oogai Y, Matsuo M, Hashimoto M, Kato F, Sugai M, Komatsuzawa H .  Expressions of virulence factors in Staphylococcus aureus grown in serum. .  Appl. Environ. Microbiol.77 ( 22 ) 8097 - 8105   2011.11Expressions of virulence factors in Staphylococcus aureus grown in serum.Reviewed

Murakami E, Nagata M, Shimoda Y, Kucho K, Higashi S, Abe M, Hashimoto M, Uchiumi T. .  Nitric Oxide Production Induced in Roots of Lotus japonicus by Lipopolysaccharide from Mesorhizobium loti. .  Plant Cell Physiol52 ( 4 ) 610 - 617   2011.4Nitric Oxide Production Induced in Roots of Lotus japonicus by Lipopolysaccharide from Mesorhizobium loti.Reviewed

Kariya, K., Yoshihara, Y., Nakao, Y., Sakurai, N., Ueno, M., Hashimoto, M., Suda .  Carboxymethyl chitin promotes chondrogenesis by inducing the production of growth factors from immune cells .  J. Biomed. Mater. Res.94 ( 4 ) 1034 - 1041   2010.9Carboxymethyl chitin promotes chondrogenesis by inducing the production of growth factors from immune cellsReviewed

Azuma M, Sawahata R, Akao Y, Ebihara T, Yamazaki S, Matsumoto M, Hashimoto M, Fukase K, Fujimoto Y, Seya T. .  The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation. .  PLoS One. 5 ( 9 ) e12550   2010.9The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation.Reviewed

Fujimoto Y, Hashimoto M, Furuyashiki M, Katsumoto M, Seya T, Suda Y, Fukase K. .  Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: prediction with mrna expression, chemical synthesis, and immunostimulatory activities. .  Chembiochem.10 ( 14 ) 2311 - 2315   2009.9Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: prediction with mrna expression, chemical synthesis, and immunostimulatory activities. Reviewed

Tawaratsumida K, Furuyashiki M, Katsumoto M, Fujimoto Y, Fukase K, Suda Y, Hashimoto M. .  Characterization of N-terminal structure of TLR2-activating lipoprotein in Staphylococcus aureus. .  J. Biol. Chem.284 ( 14 ) 9147 - 9152   2009.4Characterization of N-terminal structure of TLR2-activating lipoprotein in Staphylococcus aureus.Reviewed

Carmelo Segovia del Castillo, Takeshi Yoshikawa, Masahito Hashimoto and Taizo Sakata, .  Correlation between Chemical Structures and Inhibitory Activities of Anti-bacterial Substances from Marine Pseudoalteromonas sp. A1-J11 .  Fish Pathol. 43 ( 2 ) 65 - 71   2008.7Correlation between Chemical Structures and Inhibitory Activities of Anti-bacterial Substances from Marine Pseudoalteromonas sp. A1-J11Reviewed

Hashimoto, M., Takashige, K., Furuyashiki, M., Yoshidome, K., Sano, R., Kawamura, Y., Ijichi, S., Morioka, H., Koide, H., Oku, M., Moriya, Y., Kusumoto, S., Suda, Y. .  Enhancement of antitumor activity of OK-432 (Picibanil) by Triton X-114 phase partitioning. .  Int. Immunopharmacol. 8 ( 1 ) 12 - 19   2008.1Enhancement of antitumor activity of OK-432 (Picibanil) by Triton X-114 phase partitioning.Reviewed

Kariya H, Kiyohara A, Masuda S, Yoshihara Y, Ueno M, Hashimoto M, Suda Y. .  Biological roles of carboxymethyl-chitin associated for the growth factor production. .  J. Biomed. Mater. Res. Part A83 ( 1 ) 58 - 63   2007.10Biological roles of carboxymethyl-chitin associated for the growth factor production.Reviewed

Hashimoto M, Furuyashiki M, Kaseya R, Fukada Y, Akimaru M, Aoyama K, Okuno T, Tamura T, Kirikae T, Kirikae F, Eiraku N, Morioka H, Fujimoto Y, Fukase K, Takashige K, Moriya Y, Kusumoto S, Suda Y .  Evidence of immunostimulating lipoprotein co-existing in natural lipoteichoic acid fraction. .  Infect. Immun. 75 ( 4 ) 1926 - 1932   2007.4Evidence of immunostimulating lipoprotein co-existing in natural lipoteichoic acid fraction.Reviewed

Hasegawa M, Yang K, Hashimoto M, Park JH, Fujimoto Y, Nunez G, Fukase K, Inohara N .  Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments. .  J. Biol. Chem.281 ( 39 ) 29054 - 29063   2006.9Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.Reviewed

Hashimoto M, Tawaratsumida K, Kariya H, Kiyohara A, Suda Y, Krikae F, Kirikae T, Goetz F .  Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus. .  J. Immunol.177 ( 5 ) 3162 - 3169   2006.9Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus.Reviewed

M.Hashimoto, K.Tawaratsumida, H.Kariya, K.Aoyama, T.Tamura, Y.Suda .  Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components. .  Int. Immunol18 ( 2 ) 355 - 362   2006.2Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components.Reviewed

Y.Asai, Y.Ohyama, Y.Taiji, Y.Makimura, R.Tamai, M.Hashimoto, T.Ogawa .  Treponema medium glycoconjugate inhibits activation of human gingival fibroblasts stimulated with phenol-water extracts of periodontopathic bacteria. .  J. Dent. Res84 ( 5 ) 456 - 461   2005.5Treponema medium glycoconjugate inhibits activation of human gingival fibroblasts stimulated with phenol-water extracts of periodontopathic bacteria.Reviewed

Y.Asai, M.Hashimoto, H.M.Fletcher, K.Miyake,S.Akira, T.Ogawa .  Lipopolysaccharide Preparation Extracted from Porphyromonas gingivalis Lipoprotein-Deficient Mutant Shows a Marked Decrease in Toll-Like Receptor 2-Mediated Signaling. .  Infect. Immun.73 ( 4 ) 2157 - 2163   2005.4Lipopolysaccharide Preparation Extracted from Porphyromonas gingivalis Lipoprotein-Deficient Mutant Shows a Marked Decrease in Toll-Like Receptor 2-Mediated Signaling.Reviewed

M. Hashimoto, Y. Asai , T. Ogawa .  Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis .  Int. Immunol16 ( 10 ) 1431 - 1437   2004.10Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalisReviewed

エンドトキシン・自然免疫研究 14

小野敬子、俵積田一樹、隅田泰生、橋本雅仁（ Role： Joint author）

医学図書出版  2011.11 

エンドトキシン研究 12

俵積田一樹、橋本雅仁、隅田泰生（ Role： Joint author）

医学図書出版  2009.11 

橋本雅仁、松元太一、中村佳祐、大薗まみ、橋口周平   酢酸菌由来外膜小胞の収量改善の検討  

第70回日本生物工学会大会 (2018)  日本生物工学会

橋本雅仁、松元太一、中村佳祐、馬場梨沙子、大薗まみ、橋口周平   Acetobacter pasteurianus 由来外膜小胞の分離と免疫刺激能  

2017年度生命科学系学会合同年次大会 

橋本雅仁   酢酸菌リポ多糖の構造と生物活性   Invited

酢酸菌研究会第９回研究集会  酢酸菌研究会

橋本雅仁、松元太一、馬場梨沙子、大薗まみ、橋口周平   酢酸菌由来外膜小胞の産生と性質  

第69回日本生物工学会  日本生物工学会

橋本雅仁   黒酢に含まれる細菌成分とその生物活性   Invited

動物植物生態三学会合同鹿児島例会  動物植物生態三学会

橋本雅仁   酢酸菌由来リポ多糖と黒酢   Invited

第52回自然免疫賦活技術研究会  自然免疫賦活技術研究会