Updated on 2023/10/05

写真a

 
TAKEZAKI Toshiro
 
Organization
University Hospital, Medical and Dental Sciences Area University Hospital Management Facilities Community Medicine Support Center Professor
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine
Research Field in Cooperation, Integrated Arts and Sciences Area International Center for Island Studies, Professor
Title
Professor

Degree

  • 博士(医学) ( 1991.11   鹿児島大学 )

Research Interests

  • 地域医療

  • Epidemiology

  • 分子疫学

  • 離島

  • がん

Research Areas

  • Life Science / Hygiene and public health (non-laboratory)  / Epidemiology

  • Life Science / Hygiene and public health (non-laboratory)  / Community Medicine

  • Life Science / Hygiene and public health (laboratory)  / Molecular Epidemiology

Education

  • Nagasaki University   Faculty of Medicine   School of Medicine

    1976.4 - 1982.3

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    Country: Japan

Research History

  • Kagoshima University   Professor

    2022.4

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Health Research Course Island Medicine and International Health   Professor

    2003.11 - 2022.3

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine

    2007.4 - 2022.3

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine

    2017.4 - 2019.3

  • Kagoshima University   Research Field in Integrated Studies, Integrated Arts and Sciences Area The Research Center for the Pacific Islands   Professor

    2012.4 - 2022.3

  • Kagoshima University   Professor

    2019.5 - 2022.3

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Professional Memberships

  • Japanese Epidemiological Association

    1993.9

  • Japanese Society of Public Health

    1993.12

  • Japan Primary Care Association

    2007.4

  • Journal of Conference for Emergency Medicine in Rural Areas and Isolated Islands

    2004.10

  • Japan Society for Medical Education

    2007.10

  • Kyushu Community Medicine Educational Association

    2001.4

  • Japan Society of Ningen Dock

    2019.4

  • 日本小児科学会

    1983.1

  • 鹿児島農村医学研究会

    2005.8

  • 日本がん分子疫学研究会

    1993.5

  • 日本小児保健学会

    1983.1

  • 鹿児島県JICA派遣専門家連絡会

    2004.2

  • 日本がん予防学会

    1994.10 - 2022.3

  • 日本癌学会

    1993.3 - 2018.1

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Committee Memberships

  • へき地離島救急医療学会   幹事  

    2015.10   

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    Committee type:Other

  • 鹿児島農村医学研究会   会長  

    2014.8   

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    Committee type:Other

  • 鹿児島県JICA派遣専門家連絡会   幹事  

    2014.4   

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    Committee type:Other

  • 一般社団法人日本疫学会   理事  

    2015.12 - 2017.11   

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    Committee type:Academic society

  • 特定非営利活動法人こども医療ネットワーク   理事  

    2006.3 - 2022.3   

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    Committee type:Other

    特定非営利活動法人こども医療ネットワーク

Qualification acquired

  • Attending physician

  • Authorized medicine

  • Authorized medicine

 

Papers

  • Hanyuda A., Goto A., Katagiri R., Koyanagi Y.N., Nakatochi M., Sutoh Y., Nakano S., Oze I., Ito H., Yamaji T., Sawada N., Iwagami M., Kadota A., Koyama T., Katsuura-Kamano S., Ikezaki H., Tanaka K., Takezaki T., Imoto I., Suzuki M., Momozawa Y., Takeuchi K., Narita A., Hozawa A., Kinoshita K., Shimizu A., Tanno K., Matsuo K., Tsugane S., Wakai K., Sasaki M., Yamamoto M., Iwasaki M. .  Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation .  Scientific Reports13 ( 1 ) 7052   2023.12

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    Language:Japanese   Publisher:Scientific Reports  

    Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed to determine the causal association between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), and fasting C-peptide and colorectal cancer risk. In the single nucleotide polymorphism (SNP)-exposure analysis, we meta-analysed study-level genome-wide associations of fasting glucose (~ 17,289 individuals), HbA1c (~ 52,802 individuals), and fasting C-peptide (1,666 individuals) levels from the Japanese Consortium of Genetic Epidemiology studies. The odds ratios of colorectal cancer were 1.01 (95% confidence interval [CI], 0.99–1.04, P = 0.34) for fasting glucose (per 1 mg/dL increment), 1.02 (95% CI, 0.60–1.73, P = 0.95) for HbA1c (per 1% increment), and 1.47 (95% CI, 0.97–2.24, P = 0.06) for fasting C-peptide (per 1 log increment). Sensitivity analyses, including Mendelian randomisation-Egger and weighted-median approaches, revealed no significant association between glycaemic characteristics and colorectal cancer (P > 0.20). In this study, genetically predicted glycaemic characteristics were not significantly related to colorectal cancer risk. The potential association between insulin resistance and colorectal cancer should be validated in further studies.

    DOI: 10.1038/s41598-023-33966-7

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  • Hara Megumi, Nishida Yuichiro, Tanaka Keitaro, Shimanoe Chisato, Koga Kayoko, Furukawa Takuma, Higaki Yasuki, Shinchi Koichi, Ikezaki Hiroaki, Murata Masayuki, Takeuchi Kenji, Tamura Takashi, Hishida Asahi, Tsukamoto Mineko, Kadomatsu Yuka, Matsuo Keitaro, Oze Isao, Mikami Haruo, Kusakabe Miho, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Nakagawa-Senda Hiroko, Matsui Daisuke, Koyama Teruhide, Kuriki Kiyonori, Takashima Naoyuki, Nakamura Yasuyuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Wakai Kenji .  中高強度の身体活動と座位行動は独立して腎機能と関連する 横断研究(Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study) .  Journal of Epidemiology33 ( 5-6 ) 285 - 293   2023.6中高強度の身体活動と座位行動は独立して腎機能と関連する 横断研究(Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study)

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    Language:English   Publisher:(一社)日本疫学会  

    <Highlight>●不十分な中高強度の身体活動と長い座位行動は独立して腎機能と関連する。●高強度の身体活動と慢性腎臓病(CKD)の関連は性別で交互作用がみられる。●1時間の座位行動を身体活動に置き換えるとCKDのオッズ比が3から4%低くなる。(著者抄録)

  • Nindita Yora, Nakatochi Masahiro, Ibusuki Rie, Shimoshikiryo Ippei, Nishimoto Daisaku, Shimatani Keiichi, Takezaki Toshiro, Ikezaki Hiroaki, Murata Masayuki, Hara Megumi, Nishida Yuichiro, Tamura Takashi, Hishida Asahi, Nagayoshi Mako, Okada Rieko, Matsuo Keitaro, Ito Hidemi, Mikami Haruo, Nakamura Yohko, Otani Takahiro, Suzuki Sadao, Koyama Teruhide, Ozaki Etsuko, Kuriki Kiyonori, Takashima Naoyuki, Miyagawa Naoko, Arisawa Kokichi, Katsuura-Kamano Sakurako, Momozawa Yukihide, Kubo Michiaki, Takeuchi Kenji, Wakai Kenji, the Japan Multi-Institutional Collaborative Cohort Study Group .  HDLコレステロール値に対する喫煙、飲酒、遺伝要因のJ-MICC研究参加者における集団ベースの影響(Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants) .  Journal of Epidemiology33 ( 3-4 ) 193 - 200   2023.4HDLコレステロール値に対する喫煙、飲酒、遺伝要因のJ-MICC研究参加者における集団ベースの影響(Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants)

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    Language:English   Publisher:(一社)日本疫学会  

    <Highlight>●飲酒、日常活動、習慣的運動、卵摂取および女性はHDLコレステロール値と正の関連、喫煙、BMIおよび年齢は負の関連を示した。●GWASにおいて、7 SNP(CETP、APOA5、LIPC、LPL、ABCA1、LIPG、APOE)がHDLコレステロール値と関連していた。●非遺伝要因における、低HDLコレステロールに対するPAFは男性が最も高かった。●遺伝要因における、低HDL-Cに対するPAFはCETP rs3764261が最も高かった。●低HDLコレステロールに対する遺伝要因であるCETP rs3764261のPAFは、喫煙よりも高く、飲酒よりも低く、非遺伝要因と同程度のインパクトを有していることが示された。(著者抄録)

  • 嶽﨑俊郎、東桂子、古田真美、太鼓真規、大脇哲洋、網谷真理恵、指宿りえ、水間喜美子 .  鹿児島県における42年間の全死亡、悪性新生物、脳卒中の標準化死亡比の地域比較と経年変化 .  九州農医30・31   32 - 39   2023.3鹿児島県における42年間の全死亡、悪性新生物、脳卒中の標準化死亡比の地域比較と経年変化Invited

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Nakamura S., Fang X., Saito Y., Narimatsu H., Ota A., Ikezaki H., Shimanoe C., Tanaka K., Kubo Y., Tsukamoto M., Tamura T., Hishida A., Oze I., Koyanagi Y.N., Nakamura Y., Kusakabe M., Takezaki T., Nishimoto D., Suzuki S., Otani T., Kuriyama N., Matsui D., Kuriki K., Kadota A., Nakamura Y., Arisawa K., Katsuura-Kamano S., Nakatochi M., Momozawa Y., Kubo M., Takeuchi K., Wakai K. .  Effects of gene–lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis .  PLoS ONE18 ( 2 February ) e0279169   2023.2

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    Language:Japanese   Publisher:PLoS ONE  

    Background The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene–environment interactions, has been attracting attention in recent years. However, evidence for gene–environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene–lifestyle interactions in practice could aid in optimizing interventions according to genetic risk. Methods This study aimed to elucidate the effects of gene–lifestyle interactions on body mass index (BMI). Cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study were used. Interactions between a multi-locus genetic risk score (GRS), calculated from 76 ancestry-specific single nucleotide polymorphisms, and nutritional intake or physical activity were assessed using a linear mixed-effect model. Results The mean (standard deviation) BMI and GRS for all participants (n = 12,918) were 22.9 (3.0) kg/m2 and -0.07 (0.16), respectively. The correlation between GRS and BMI was r (12,916) = 0.13 (95% confidence interval [CI] 0.11–0.15, P < 0.001). An interaction between GRS and saturated fatty acid intake was observed (β = -0.11, 95% CI -0.21 to -0.02). An interaction between GRS and n-3 polyunsaturated fatty acids was also observed in the females with normal-weight subgroup (β = -0.12, 95% CI -0.22 to -0.03). Conclusion Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene–lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition.

    DOI: 10.1371/journal.pone.0279169

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  • Saito Yoshinobu, Oguma Yuko, Nakamura Sho, Narimatsu Hiroto, Nakashima Ryoko, Ikezaki Hiroaki, Tanaka Keitaro, Hara Megumi, Tamada Yudai, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Oze Isao, Taniyama Yukari, Mikami Haruo, Nagase Hiroki, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Otani Takahiro, Koyama Teruhide, Watanabe Isao, Kuriki Kiyonori, Kita Yoshikuni, Takashima Naoyuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Takeuchi Kenji, Wakai Kenji, J-MICC Study Group .  Questionnaire-assessed physical activity among Japanese adults: The J-MICC Study .  Research in Exercise Epidemiologyadvpub ( 0 )   2023Questionnaire-assessed physical activity among Japanese adults: The J-MICC Study

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    Language:Japanese   Publisher:Japanese Association of Exercise Epidemiology  

    DOI: 10.24804/ree.2154

  • Nishimoto Daisaku, Kodama Shimpei, Shimoshikiryo Ippei, Ibusuki Rie, Nerome Yasuhito, Takezaki Toshiro, Nishio Ikuko .  Association Between Nursing Discussions, Resilience, Workplace Social Support and Burnout: A Quantitative Study in Japan .  Yonago Acta Medica66 ( 3 ) 355 - 364   2023Association Between Nursing Discussions, Resilience, Workplace Social Support and Burnout: A Quantitative Study in Japan

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    Language:English   Publisher:Tottori University Medical Press  

    <p><b>Background </b>Although it is known that resilience is negatively associated with burnout, and that certain interventions can effectively increase resilience, little is known about online resilience-enhancing interventions during the COVID-19 crisis. The aim of this study was to identify the association between an online resilience-enhancing intervention and workplace social support, and burnout among nurses working in the mainland and remote islands of Japan during the COVID-19 crisis.</p><p><b>Methods </b>Pretest-posttest was conducted between April 2020 and February 2021, and the questionnaire survey included the bidimensional resilience scale, the Japanese version of Pine’s Burnout Measure, and the workplace social support scale. Changes in burnout, resilience, and social support and the associations with nursing discussions as intervention were analyzed. Participants were 98 Nurses with 1 to 10 years of experience from Japan’s mainland and remote island hospitals of Kagoshima Prefecture participated in a baseline survey in April 2020. Of these, 76 participated in a secondary survey in September 2020, and 69 participated in the intervention program and a third survey in February 2021. The online intervention over Zoom consisted of small-group nursing discussions based on the broaden-and-build theory.</p><p><b>Results </b>Changes in burnout showed a significant negative association with change in workplace social support (Coef. = –0.019, 95% CI –0.035– –0.003), as did the interaction between change in acquired resilience and intervention (Coef. = –0.088, 95% CI –0.164– –0.011).</p><p><b>Conclusion </b>Change in workplace social support was significantly negatively associated with changes in burnout, as was the interaction of intervention and acquired resilience. Promotion of this intervention and making workplace social support more accessible may contribute to reduce burnout in nurses.</p>

    DOI: 10.33160/yam.2023.08.008

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  • Fujii Ryosuke, Hishida Asahi, Nishiyama Takeshi, Nakatochi Masahiro, Matsuo Keitaro, Ito Hidemi, Nishida Yuichiro, Shimanoe Chisato, Nakamura Yasuyuki, Turin Tanvir Chowdhury, Suzuki Sadao, Watanabe Miki, Ibusuki Rie, Takezaki Toshiro, Mikami Haruo, Nakamura Yohko, Ikezaki Hiroaki, Murata Masayuki, Kuriki Kiyonori, Kuriyama Nagato, Matsui Daisuke, Arisawa Kokichi, Katsuura-Kamano Sakurako, Tsukamoto Mineko, Tamura Takashi, Kubo Yoko, Kondo Takaaki, Momozawa Yukihide, Kubo Michiaki, Takeuchi Kenji, Wakai Kenji .  地域住民を対象としたJ-MICC Studyにおける高感度CRPと腎機能との関係に関するメンデルランダム化解析による評価(Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study) .  Journal of Epidemiology32 ( 11-12 ) 483 - 488   2022.12地域住民を対象としたJ-MICC Studyにおける高感度CRPと腎機能との関係に関するメンデルランダム化解析による評価(Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study)

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    Language:English   Publisher:(一社)日本疫学会  

    <Highlight>●本研究では、10,542名の日本人集団を対象にメンデルランダム化解析の手法を用いて、高感度CRP(hs-CRP)と推定糸球体濾過量(eGFR)の因果関係を推定した。●我々は、欧米人集団およびアジア人集団で同定されたSNPに基づいた異なる2つの操作変数(IVCRPとIVAsian)を使用した。●2つの操作変数(IVCRPとIVAsian)によるhs-CRPの説明率は、それぞれ3.4%と3.9%であった。●従来の線形回帰分析の結果、血清hs-CRP濃度とeGFRとの有意な関連を認めた。●2つの操作変数(IVCRPとIVAsian)を使用したtwo-sample MRを行なった結果、血清hs-CRPとeGFRとの因果関係を支持するものではなかった。(著者抄録)

  • Saita K., Sumitani M., Nishizawa D., Tamura T., Ikeda K., Wakai K., Sudo Y., Abe H., Otonari J., Ikezaki H., Takeuchi K., Hishida A., Tanaka K., Shimanoe C., Takezaki T., Ibusuki R., Oze I., Ito H., Ozaki E., Matsui D., Nakamura Y., Kusakabe M., Suzuki S., Nakagawa-Senda H., Arisawa K., Katsuura-Kamano S., Kuriki K., Kita Y., Nakamura Y., Momozawa Y., Uchida K. .  Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study .  Medicine (United States)101 ( 37 ) e30580   2022.9

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    Language:Japanese   Publisher:Medicine (United States)  

    Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598) - located on the gene encoding for pleiotrophin on chromosome 7 - that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (P = 1.31 × 10-7, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (P =.028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing.

    DOI: 10.1097/MD.0000000000030580

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  • Nishimoto Daisaku, Imajo Mine, Kodama Shimpei, Shimoshikiryo Ippei, Ibusuki Rie, Nerome Yasuhito, Takezaki Toshiro, Nishio Ikuko .  鹿児島県内の臨床看護師のバーンアウトに対するレジリエンスと関連要因の影響(The Effects of Resilience and Related Factors on Burnout in Clinical Nurses, Kagoshima, Japan) .  Yonago Acta Medica65 ( 2 ) 148 - 159   2022.5鹿児島県内の臨床看護師のバーンアウトに対するレジリエンスと関連要因の影響(The Effects of Resilience and Related Factors on Burnout in Clinical Nurses, Kagoshima, Japan)

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    Language:English   Publisher:ヨナゴ・アクタ・メディカ刊行会  

    鹿児島県内の2施設で働く臨床看護師を対象に、バーンアウトに対してレジリエンスと関連要因が及ぼす影響を横断的に調査した。本質問紙調査にはPinesのバーンアウト尺度や二次元レジリエンス要因尺度などを使用し、2020年4月に実施した。2施設のうち一方は本土の都市部にある500床を超える三次医療機関で、看護師82名(本土群)に質問紙を配布した。もう一方は離島にある中核病院であり、看護師70名(離島群)に配布した。合わせて99名(65%)から回答が得られ、不適格の1名を除く本土群59名(女性51名、性別記載なし1名)と離島群39名(女性28名)の回答内容を解析した。バーンアウトの有症率は本土群で20%、離島群で36%であった。生得的レジリエンスという要因はバーンアウトと負に関連していることがどちらの群でも示された。また獲得的レジリエンスにも同様の関連性が観察された(本土群でP=0.007、離島群でP=0.057)。全集団においては、生得的レジリエンスと職場での社会的支援がバーンアウトと負に関連し、離職意図は正に関連していることが示された。

  • Ohashi Mizuki, Miura Katsuyuki, Takashima Naoyuki, Kadota Aya, Saito Yoshino, Tsuji Shunichiro, Murakami Takashi, Kadomatsu Yuka, Nagayoshi Mako, Hara Megumi, Tanaka Keitaro, Tamura Takashi, Hishida Asahi, Takezaki Toshiro, Shimoshikiryo Ippei, Ozaki Etsuko, Watanabe Isao, Suzuki Sadao, Watanabe Miki, Kuriki Kiyonori, Arisawa Kokichi, Katsuura-Kamano Sakurako, Yamasaki Sho, Ikezaki Hiroaki, Oze Isao, Koyanagi Yuriko N., Mikami Haruo, Nakamura Yohko, Takeuchi Kenji, Kita Yoshikuni, Wakai Kenji, the Japan Multi-institutional Collaborative Cohort(J-MICC) Study Group .  閉経状態別にみた妊娠歴と高血圧および肥満との関連 J-MICC研究(The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study) .  Hypertension Research45 ( 4 ) 708 - 714   2022.4閉経状態別にみた妊娠歴と高血圧および肥満との関連 J-MICC研究(The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study)

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    Language:English   Publisher:Nature Publishing Group  

    J-MICC研究から得たデータを用いて、妊娠歴と高血圧および肥満との関連について検討した。J-MICC研究のベースライン調査では各種身体データ、血液サンプル、自記式問診票データが収集された。8地域の女性24558名を解析対象とした。ロジスティック回帰分析の結果、閉経前女性において出産は高血圧に対して全般的に予防効果を示した。しかし、肥満に対する影響は認められなかった。閉経後女性において、出産は肥満および高血圧と正の相関を示したが、BMI調整後、高血圧との相関は認められなくなった。以上から、妊娠歴は高血圧および肥満と関連しているが、この関連は閉経前女性と閉経後女性で異なっていることが示された。

  • Amitani M, Amitani H, Suzuki H, Kawazu S, Mizuma K, Yamaguchi K, Oki T, Nitta H, Sonoda T, Kawano K, Tanaka Y, Uto N, Ibusuki R, Arita R, Takayama S, Mitsuma T, Takezaki T, Asakawa A, Owaki T .  Application of objective structured clinical examination (OSCE) for the evaluation of Kampo medicine training. .  BMC medical education22 ( 1 ) 202   2022.3Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:BMC Medical Education  

    Background: The purpose of this study was to develop an objective, content-valid, and reliable assessment method for Kampo medicine using an objective structured clinical examination (OSCE) for the assessment of clinical competence in Kampo medicine. Methods: We developed a blueprint followed by a list of 47 assessment items and three task scenarios related to clinical competence in Kampo medicine. An eight-member test committee checked the relevance of the assessment items on a Likert scale. We calculated a content validity index and content validity ratio, and used the Angoff method to set the passing threshold. We trained a total of nine simulated patients with three assigned to each scenario. We conducted an OSCE for 11 candidates with varying medical abilities, and conducted three stations per person, which were evaluated by one evaluator in one room by direct observation. We used video recordings to test the inter-rater reliability of the three raters. We used the test results to verify the reliability of the assessment chart. Results: The inter-rater reliability (intraclass correlation coefficient [2,1]) was 0.973. The reliability of the assessment chart for each scenario (Cronbach’s α) was 0.86, 0.89, and 0.85 for Scenarios 1, 2, and 3, respectively. The reliability of the assessment chart for the whole OSCE (Cronbach’s α) was 0.90. Conclusions: We developed a content-valid new OSCE assessment method for Kampo medicine and obtained high inter-rater and test reliabilities. Our findings suggest that this is one of the most reliable evaluation methods for assessing clinical competence in Kampo medicine.

    DOI: 10.1186/s12909-022-03264-3

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  • Matsunaga T. .  Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study .  PLoS ONE17 ( 1 January ) e0262252   2022.1Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PLoS ONE  

    Objective The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. Methods The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Results Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose–response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ?4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ?55 years old. Conclusions Breastfeeding history may be related to lower prevalence of metabolic syndrome in middleaged parous women.

    DOI: 10.1371/journal.pone.0262252

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  • Ohashi M. .  The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study .  Hypertension Research45 ( 4 ) 708 - 714   2022Reviewed International journal

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    Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status. We evaluated the association of reproductive history with hypertension and obesity using a large cross-sectional dataset from the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). At the baseline survey, physical data, blood samples, and self-reported health questionnaires were collected. Participants with insufficient data were excluded, and 24,558 women from eight study regions were included in this study. Logistic regression analysis was conducted to evaluate the association of reproductive history with hypertension and obesity using multivariable-adjusted odds ratios. In premenopausal women, childbirth showed a generally protective effect on hypertension but not on obesity. In postmenopausal women, childbirth was positively associated with obesity and hypertension but not with hypertension after adjusting for BMI. In conclusion, reproductive history was associated with hypertension and obesity in a large Japanese population, and this association differed between premenopausal and postmenopausal women.

    DOI: 10.1038/s41440-021-00820-0

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  • Nishimoto Daisaku, Imajo Mine, Kodama Shimpei, Shimoshikiryo Ippei, Ibusuki Rie, Nerome Yasuhito, Takezaki Toshiro, Nishio Ikuko .  The Effects of Resilience and Related Factors on Burnout in Clinical Nurses, Kagoshima, Japan .  Yonago Acta Medica65 ( 2 ) 148 - 159   2022

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    <p><b>Background </b>Burnout, due to extreme mental and physical fatigue, and emotional exhaustion, leads to decreased nursing quality and turnover. However, not all nurses are observed as burnouts in the same work environment, and resilience and related factors may have effects on the development of burnouts. Therefore, we conducted a cross-sectional study to examine the effects of resilience and related factors on the burnout in clinical nurses, Kagoshima, Japan.</p><p><b>Methods </b>Data for this cross-sectional study involving nurses (<i>n</i> = 98) was collected using the following questionnaire surveys: the Bidimensional Resilience Scale, The Workplace Social Support Scale, and the Japanese version of the Pine’s Burnout Scale. Using burnout as a dependent variable, analyses were conducted using one-way analysis of variance and multiple regression analysis after adjusted for related factors.</p><p><b>Results </b>The prevalence of burnouts was 19.6% on the mainland and 36.1% on remote island. Innate resilience, acquired resilience, workplace social support, and burnout showed no significant difference between nurses on the mainland and remote island. In the mainland participants, innate resilience (β = –0.492, <i>P</i> < 0.001) and acquired resilience (β = –0.325, <i>P</i> = 0.007) showed a negative association with burnout, and similar associations were observed innate resilience (β = –0.520, <i>P</i> = 0.004) and acquired resilience (β = –0.336, <i>P</i> = 0.057) in the remote island participants. For all participants, innate resilience (β = –0.443, <i>P</i> = 0.001) and workplace social support (β = –0.204, <i>P</i> = 0.031) showed a negative association with burnout, and turnover intention was positively associated (β = 0.025, <i>P</i> = 0.021).</p><p><b>Conclusion </b>A negative association between burnout and innate resilience factors was observed in the mainland and remote island. Further evaluation of innate resilience is necessary for burnout prevention in clinical nurses.</p>

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  • Yasuda T., Miyamoto K., Akaho T., Ibusuki R., Shimoshikiryo I., Nishimoto D., Takezaki T. .  Intake of local vegetables and decreased risk of mortality and cancer incidence in Amami island regions, Japan .  Asia Pacific journal of clinical nutrition31 ( 4 ) 780 - 789   2022

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    BACKGROUND AND OBJECTIVES: There is emerging scientific evidence of the health benefits of traditional food plants at both molecular and folk remedy levels; however, epidemiological observations are limited. The Amami island region of Japan has a variety of unique traditions conserved till today, where a cohort study was conducted in 2005. The objective of this study was to investigate the associations between the intake of common and local vegetables and the risk of mortality and cancer incidence in Amami. METHODS AND STUDY DESIGN: Participants were enrolled from the general population of Amami as part of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. In total, 5,015 participants (2,053 men and 2,962 women) aged 35-69 years were enrolled in this study. They were followed up to obtain information on movement, death, and cancer incidence. The hazard ratios (HRs) and 95% CIs were estimated using the Cox proportional hazard model after adjusting for potential confounding factors. RESULTS: A significant inverse association was observed between cabbage intake and the HRs for overall mortality (p for trend=0.046) and lung cancer incidence (p=0.016). Intake of handama and togan as local vegetables was associated with decreased HRs for overall mortality (p=0.019 and 0.036, respectively). CONCLUSIONS: While the molecular and biochemical reasoning and residual confounding factors behind this association remain unclear, the findings of this study suggest that the dietary lifestyle in Amami has a positive impact on the residents, which can significantly decrease mortality risk.

    DOI: 10.6133/apjcn.202212_31(4).0020

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  • Takeuchi Kenji, Naito Mariko, Kawai Sayo, Tsukamoto Mineko, Kadomatsu Yuka, Kubo Yoko, Okada Rieko, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Nakatochi Masahiro, Sasakabe Tae, Hashimoto Shuji, Eguchi Hidetaka, Momozawa Yukihide, Ikezaki Hiroaki, Murata Masayuki, Furusyo Norihiro, Tanaka Keitaro, Hara Megumi, Nishida Yuichiro, Matsuo Keitaro, Ito Hidemi, Oze Isao, Mikami Haruo, Nakamura Yohko, Kusakabe Miho, Takezaki Toshiro, Ibusuki Rie, Shimoshikiryo Ippei, Suzuki Sadao, Nishiyama Takeshi, Watanabe Miki, Koyama Teruhide, Ozaki Etsuko, Watanabe Isao, Kuriki Kiyonori, Kita Yoshikuni, Ueshima Hirotsugu, Matsui Kenji, Arisawa Kokichi, Uemura Hirokazu, Katsuura-Kamano Sakurako, Nakamura Sho, Narimatsu Hiroto, Hamajima Nobuyuki, Tanaka Hideo, Wakai Kenji .  Study Profile of the Japan Multi-institutional Collaborative Cohort(J-MICC) Study(和訳中) .  Journal of Epidemiology31 ( 11-12 ) 660 - 668   2021.12Study Profile of the Japan Multi-institutional Collaborative Cohort(J-MICC) Study(和訳中)Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:(一社)日本疫学会  

    2005年に開始された、癌を含む生活習慣病の遺伝子-環境相互作用を調べるための日本多施設共同コホート(J-MICC)研究について、研究デザインならびに参加者のベースラインプロファイルについて報告した。2005年~2014年にかけ行われたベースライン調査では、12府県14の調査地域に居住する住民92610名(男性40880名、女性51730名、年齢35歳~69歳)を対象に、属性や学歴、飲酒、喫煙、睡眠、運動、食物摂取頻度、服薬やサプリメントの使用、本人および家族の既往歴や精神的ストレスおよび妊娠歴に関するアンケート調査と、末梢血試料を生体試料として採取した。なお、本調査への参加率の平均33.5%で、最も参加が得られた年齢層は男性が65歳~69歳、女性が60歳~64歳であり、男女間でBMIや学歴、飲酒、喫煙および睡眠時間に差が認められたものの、本研究により、9万人以上の参加者から、ライフスタイルに関する臨床データや生体試料が収集された。また、大規模集団による本コホート研究は、健康寿命を支援するエビデンス提供の面でも、国内外科学コミュニティの貴重な資源となり得ることが期待された。

  • Katsuura-Kamano S. .  Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population: Baseline data from the Japan Multi-Institutional Collaborative cohort study .  Preventive Medicine Reports24   101613   2021.12Reviewed International journal

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    The purpose of the study was to investigate sex-specific associations of skipping breakfast and short sleep duration with metabolic syndrome (MetS) and their interaction. We analyzed baseline data of 14,907 men and 14,873 women aged 35–69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study from 2005. MetS was diagnosed using a modification of the National Cholesterol Education Program Adult Treatment Panel III revised definition (NCEP-R 2005), using body mass index instead of waist circumference. Breakfast consumption was classified into two categories: ≥6 days/week (consumers) or <6 days/week (skippers). Sleep duration was classified into three categories: <6h, 6 to <8 h, and ≥8 h/day. Multivariate logistic regression analysis was performed to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) and examine the presence of interaction. In men, skipping breakfast and short sleep duration were independently associated with an increased prevalence of MetS (OR 1.26, 95%CI 1.12–1.42 and OR 1.28, 95%CI 1.12–1.45, respectively), obesity, and components of MetS. However, no significant interaction was observed between skipping breakfast and short sleep duration. In women, skipping breakfast and short sleep duration were associated with an increased prevalence of obesity, but not with MetS. These findings indicate that breakfast consumption and moderate sleep duration may be associated with a lower risk of MetS, particularly in men.

    DOI: 10.1016/j.pmedr.2021.101613

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  • Nakamura Y. .  A genome-wide association study on meat consumption in a Japanese population: The Japan Multi-Institutional Collaborative Cohort study .  Journal of Nutritional Science10   e61   2021.10Reviewed International journal

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    Recent genome-wide association studies (GWAS) on the dietary habits of the Japanese population have shown that an effect rs671 allele was inversely associated with fish consumption, whereas it was directly associated with coffee consumption. Although meat is a major source of protein and fat in the diet, whether genetic factors that influence meat-eating habits in healthy populations are unknown. This study aimed to conduct a GWAS to find genetic variations that affect meat consumption in a Japanese population. We analysed GWAS data using 14 076 participants from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. We used a semi-quantitative food frequency questionnaire to estimate food intake that was validated previously. Association of the imputed variants with total meat consumption per 1000 kcal energy was performed by linear regression analysis with adjustments for age, sex, and principal component analysis components 1-10. We found that no genetic variant, including rs671, was associated with meat consumption. The previously reported single nucleotide polymorphisms that were associated with meat consumption in samples of European ancestry could not be replicated in our J-MICC data. In conclusion, significant genetic factors that affect meat consumption were not observed in a Japanese population.

    DOI: 10.1017/jns.2021.49

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  • Kawamura Y. .  A proposal for practical diagnosis of renal hypouricemia: Evidenced from genetic studies of nonfunctional variants of urat1/slc22a12 among 30,685 japanese individuals .  Biomedicines9 ( 8 )   2021.8Reviewed International journal

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    Background: Renal hypouricemia (RHUC) is characterized by a low serum uric acid (SUA) level and high fractional excretion of uric acid (FEUA). Further studies on FEUA in hypouricemic individuals are needed for a more accurate diagnosis of RHUC. Methods: In 30,685 Japanese health-examination participants, we genotyped the two most common nonfunctional variants of URAT1 (NFV-URAT1), W258X (rs121907892) and R90H (rs121907896), in 1040 hypouricemic individuals (SUA ≤ 3.0 mg/dL) and 2240 individuals with FEUA data. The effects of NFV-URAT1 on FEUA and SUA were also investigated using linear and multiple regression analyses. Results: Frequency of hypouricemic individuals (SUA ≤ 3.0 mg/dL) was 0.97% (male) and 6.94% (female) among 30,685 participants. High frequencies of those having at least one allele of NFV-URAT1 were ob-served in 1040 hypouricemic individuals. Furthermore, NFV-URAT1 significantly increased FEUA and decreased SUA, enabling FEUA and SUA levels to be estimated. Conversely, FEUA and SUA data of hypouricemic individuals are revealed to be useful to predict the number of NFV-URAT1. Conclusions: Our findings reveal that specific patterns of FEUA and SUA data assist with predicting the number of nonfunctional variants of causative genes for RHUC, and can also be useful for practical diagnosis of RHUC even before genetic tests.

    DOI: 10.3390/biomedicines9081012

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  • Amitani Marie, Amitani Haruka, Suzuki Hajime, Kawazu Suguru, Fukumoto Takamasa, Yamaguchi Kojiro, Oki Toshimichi, Nitta Hideaki, Sonoda Takuro, Uto Nanami, Numata Mayumi, Mizuma Kimiko, Ibusuki Rie, Takezaki Toshiro, Owaki Tetsuhiro, Asakawa Akihiro .  Effective learning strategies for Japanese Kampo medicine using problem-based learning and simulator training for medical students: A questionnaire survey(和訳中) .  Traditional & Kampo Medicine8 ( 2 ) 155 - 162   2021.8Effective learning strategies for Japanese Kampo medicine using problem-based learning and simulator training for medical students: A questionnaire survey(和訳中)Reviewed International journal

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    医学部教育における漢方医学教育について、講義、問題解決型学習(PBL)とシミュレーター訓練を含む教育効果を検証した。講義のみのクラス(Ks-L)、講義と煎じ薬のクラス(Ks-LD)、および講義、煎じ薬、PBLとシミュレーター訓練のクラス(Ks-LDPS)の90分授業をそれぞれ8回開催した。これらのカリキュラムを評価するため、当大学医学部能力開発委員会で12項目の質問票調査のデータを分析した。Ks-LDPSは他のクラスよりも能動的学習と全体的な満足度が優れていた。講義中心の授業よりも複数の組み合わせによる学習法が、漢方医学への積極的な姿勢と自己学習を促進すると考えられた。

  • Amitani M., Amitani H., Suzuki H., Kawazu S., Fukumoto T., Yamaguchi K., Oki T., Nitta H., Sonoda T., Uto N., Numata M., Mizuma K., Ibusuki R., Takezaki T., Owaki T., Asakawa A. .  Effective learning strategies for Japanese Kampo medicine using problem-based learning and simulator training for medical students: A questionnaire survey .  Traditional and Kampo Medicine8 ( 2 ) 155 - 162   2021.8

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    Background: Kampo medicine was introduced into the core curriculum model of medical education in Japan in 2007, and has been taught at all 80 medical universities across the country. However, as there are differences in terms of content and between universities, Kampo medicine education needs to be standardized. Therefore, this study aimed to examine the effects of combining multiple strategies, including lectures, problem-based learning (PBL), and simulator training for the development of a standardized educational curriculum for Kampo medicine. Methods: We offered a lectures-only class (Kampo strategy-lectures [Ks-L]), a class with lectures and decoction (Ks-LD), a class with lectures, decoction, and PBL (Ks-LDP), and a class with lectures, decoction, PBL, and simulator training (Ks-LDPS). We analyzed the data from a 12-item questionnaire conducted by the Faculty Development Committee of Kagoshima University Faculty of Medicine to evaluate the curriculum. Results: Ks-LDPS was rated significantly higher than the other modules in active learning, and overall satisfaction. Conclusions: The results of this study suggest that combining multiple strategies rather than offering classes with lectures promoted a positive attitude to Kampo medicine and deep self-learning among students, thereby improving the educational effects of Kampo medicine education.

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  • Suzuki H. .  A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern .  European Journal of Clinical Nutrition75 ( 6 ) 937 - 945   2021.6Reviewed International journal

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    Background/Objectives: Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. Subjects/Methods: We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region. Results: We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10−8. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. Conclusion: We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.

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  • Iwase Madoka, Matsuo Keitaro, Nakatochi Masahiro, Oze Isao, Ito Hidemi, Koyanagi Yuriko, Ugai Tomotaka, Kasugai Yumiko, Hishida Asahi, Takeuchi Kenji, Okada Rieko, Kubo Yoko, Shimanoe Chisato, Tanaka Keitaro, Ikezaki Hiroaki, Murata Masayuki, Takezaki Toshiro, Nishimoto Daisaku, Kuriyama Nagato, Ozaki Etsuko, Suzuki Sadao, Watanabe Miki, Mikami Haruo, Nakamura Yohko, Uemura Hirokazu, Katsuura-Kamano Sakurako, Kuriki Kiyonori, Kita Yoshikuni, Takashima Naoyuki, Nagino Masato, Momozawa Yukihide, Kubo Michiaki, Wakai Kenji .  日本人の生涯を通じて遺伝子多型がBMIに及ぼす多様な影響 日本の多施設共同コホート研究(Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study) .  Journal of Epidemiology31 ( 3-4 ) 172 - 179   2021.4日本人の生涯を通じて遺伝子多型がBMIに及ぼす多様な影響 日本の多施設共同コホート研究(Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study)Reviewed International journal

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    <Highlight>●独立した日本人の前向きコホートの対象集団に対する横断的な検討においてBMIに関する3つの表現型と、FTO,BDNF,TMEM18,HS6ST3,BORCS7領域の遺伝子多型との間に有意な関連を認めた。●これまで欧米でBMIと関連するとして報告されてきた遺伝子領域は日本人においても関連が認められた。●調査時BMIとBMI変化量と関連する遺伝子多型は似た傾向を示したが、20歳時BMIと関連を示した遺伝子多型は他の2つの表現型とは傾向が異なっており、遺伝子多型がBMIに及ぼす影響はライフコースを通じて変化する可能性が示唆された。(著者抄録)

  • Suzuki S. .  Body mass index and colorectal cancer risk: A Mendelian randomization study .  Cancer Science112 ( 4 ) 1579 - 1588   2021.4

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    Traditional observational studies have reported a positive association between higher body mass index (BMI) and the risk of colorectal cancer (CRC). However, evidence from other approaches to pursue the causal relationship between BMI and CRC is sparse. A two-sample Mendelian randomization (MR) study was undertaken using 68 single nucleotide polymorphisms (SNPs) from the Japanese genome-wide association study (GWAS) and 654 SNPs from the GWAS catalogue for BMI as sets of instrumental variables. For the analysis of SNP-BMI associations, we undertook a meta-analysis with 36 303 participants in the Japanese Consortium of Genetic Epidemiology studies (J-CGE), comprising normal populations. For the analysis of SNP-CRC associations, we utilized 7636 CRC cases and 37 141 controls from five studies in Japan, and undertook a meta-analysis. Mendelian randomization analysis of inverse-variance weighted method indicated that a one-unit (kg/m2) increase in genetically predicted BMI was associated with an odds ratio of 1.13 (95% confidence interval, 1.06-1.20; P value <.001) for CRC using the set of 68 SNPs, and an odds ratio of 1.07 (1.03-1.11, 0.001) for CRC using the set of 654 SNPs. Sensitivity analyses robustly showed increased odds ratios for CRC for every one-unit increase in genetically predicted BMI. Our MR analyses strongly support the evidence that higher BMI influences the risk of CRC. Although Asians are generally leaner than Europeans and North Americans, avoiding higher BMI seems to be important for the prevention of CRC in Asian populations.

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  • Suzuki Shiori, Goto Atsushi, Nakatochi Masahiro, Narita Akira, Yamaji Taiki, Sawada Norie, Katagiri Ryoko, Iwagami Masao, Hanyuda Akiko, Hachiya Tsuyoshi, Sutoh Yoichi, Oze Isao, Koyanagi Yuriko N., Kasugai Yumiko, Taniyama Yukari, Ito Hidemi, Ikezaki Hiroaki, Nishida Yuichiro, Tamura Takashi, Mikami Haruo, Takezaki Toshiro, Suzuki Sadao, Ozaki Etsuko, Kuriki Kiyonori, Takashima Naoyuki, Arisawa Kokichi, Takeuchi Kenji, Tanno Kozo, Shimizu Atsushi, Tamiya Gen, Hozawa Atsushi, Kinoshita Kengo, Wakai Kenji, Sasaki Makoto, Yamamoto Masayuki, Matsuo Keitaro, Tsugane Shoichiro, Iwasaki Motoki .  BMIと大腸癌リスク メンデルランダム化研究(Body mass index and colorectal cancer risk: A Mendelian randomization study) .  Cancer Science112 ( 4 ) 1579 - 1588   2021.4BMIと大腸癌リスク メンデルランダム化研究(Body mass index and colorectal cancer risk: A Mendelian randomization study)Reviewed International journal

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    ゲノム情報を用いる研究手法のメンデルランダム化解析により、肥満度の指標であるBMIと大腸癌リスクとの関連について検討した。日本人のゲノムワイド関連解析(GWAS)で得られた68個の一塩基多型(SNP)とBMIのGWASカタログで得られた654個のSNPを操作変数として用いて、2標本のメンデルランダム化解析を実施した。SNPとBMIの関連について、日本ゲノム疫学研究コンソーシアム(J-CGE)の日本人一般集団36303人を対象にメタ解析を行った。SNPとCRCの関連については、日本の五つの試験から大腸癌症例7636人と対照者37141人を抽出しメタ解析を行った。逆分散加重法によるメンデルランダム化解析において、ゲノム情報から予測されるBMIが1単位(kg/m2)増加すると、68個のSNPを用いた場合は大腸癌のオッズ比が1.13(95%CI:1.06〜1.20)、654個のSNPを用いた場合は大腸癌のオッズ比が1.07(95%CI:1.03〜1.11)と推計された。さらに、感度分析では、ゲノム情報から予測されるBMIが1単位増加するごとに、大腸癌のオッズ比が増加した。本解析により、BMI値の上昇が大腸癌のリスクに影響を与える証拠が示された。

  • Iwase Madoka, Matsuo Keitaro, Nakatochi Masahiro, Oze Isao, Ito Hidemi, Koyanagi Yuriko, Ugai Tomotaka, Kasugai Yumiko, Hishida Asahi, Takeuchi Kenji, Okada Rieko, Kubo Yoko, Shimanoe Chisato, Tanaka Keitaro, Ikezaki Hiroaki, Murata Masayuki, Takezaki Toshiro, Nishimoto Daisaku, Kuriyama Nagato, Ozaki Etsuko, Suzuki Sadao, Watanabe Miki, Mikami Haruo, Nakamura Yohko, Uemura Hirokazu, Katsuura-Kamano Sakurako, Kuriki Kiyonori, Kita Yoshikuni, Takashima Naoyuki, Nagino Masato, Momozawa Yukihide, Kubo Michiaki, Wakai Kenji .  Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study .  Journal of Epidemiology31 ( 3 ) 172 - 179   2021.3

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    <p><b>Background:</b> Obesity is a reported risk factor for various health problems. Genome-wide association studies (GWASs) have identified numerous independent loci associated with body mass index (BMI). However, most of these have been focused on Europeans, and little evidence is available on the genetic effects across the life course of other ethnicities.</p><p><b>Methods:</b> We conducted a cross-sectional study to examine the associations of 282 GWAS-identified single nucleotide polymorphisms with three BMI-related traits, current BMI, BMI at 20 years old (BMI at 20), and change in BMI (BMI change), among 11,586 Japanese individuals enrolled in the Japan Multi-Institutional Collaborative Cohort study. Associations were examined using multivariable linear regression models.</p><p><b>Results:</b> We found a significant association (<i>P</i> < 0.05/282 = 1.77 × 10<sup>−4</sup>) between BMI and 11 polymorphisms in or near <i>FTO</i>, <i>BDNF</i>, <i>TMEM18</i>, <i>HS6ST3</i>, and <i>BORCS7</i>. The trend was similar between current BMI and BMI change, but differed from that of the BMI at 20. Among the significant variants, those on <i>FTO</i> were associated with all BMI traits, whereas those on <i>TMEM18</i> and <i>HS6SR3</i> were only associated with BMI at 20. The association of <i>FTO</i> loci with BMI remained, even after additional adjustment for dietary energy intake.</p><p><b>Conclusions:</b> Previously reported BMI-associated loci discovered in Europeans were also identified in the Japanese population. Additionally, our results suggest that the effects of each loci on BMI may vary across the life course and that this variation may be caused by the differential effects of individual genes on BMI via different pathways.</p>

    DOI: 10.2188/jea.je20190296

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  • Suzuki T. .  A genome-wide association study on fish consumption in a Japanese population—the Japan Multi-Institutional Collaborative Cohort study .  European Journal of Clinical Nutrition75 ( 3 ) 480 - 488   2021.3

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    Background/objective: Although benefits of fish consumption for health are well known, a significant percentage of individuals dislike eating fish. Fish consumption may be influenced by genetic factors in addition to environmental factors. We conducted a genome-wide association study (GWAS) to find genetic variations that affect fish consumption in a Japanese population. Methods: We performed a two-stage GWAS on fish consumption using 13,739 discovery samples from the Japan Multi-Institutional Collaborative Cohort study, and 2845 replication samples from the other population. We used a semi-quantitative food frequency questionnaire to estimate food intake. Association of the imputed variants with fish consumption was analyzed by separate linear regression models per variant, with adjustments for age, sex, energy intake, principal component analysis components 1–10, and alcohol intake (g/day). We also performed conditional analysis. Results: We found 27 single nucleotide polymorphisms (SNPs) located in 12q24 and 14q32.12 that were associated with fish consumption. The 19 SNPs were located at 11 genes including six lead SNPs at the BRAP, ACAD10, ALDH2, NAA25, and HECTD4 regions on 12q24.12-13, and CCDC197 region on 14q32.12. In replication samples, all five SNPs located on chromosome 12 were replicated successfully, but the one on chromosome 14 was not. Conditional analyses revealed that the five lead variants in chromosome 12 were in fact the same signal. Conclusion: We found that new SNPs in the 12q24 locus were related to fish intake in two Japanese populations. The associations between SNPs on chromosome 12 and fish intake were strongly confounded by drinking status.

    DOI: 10.1038/s41430-020-00702-7

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  • Usui Yoshiaki, Matsuo Keitaro, Oze Isao, Ugai Tomotaka, Koyanagi Yuriko, Maeda Yoshinobu, Ito Hidemi, Hishida Asahi, Takeuchi Kenji, Tamura Takashi, Tsukamoto Mineko, Kadomatsu Yuka, Hara Megumi, Nishida Yuichiro, Shimoshikiryo Ippei, Takezaki Toshiro, Ozaki Etsuko, Matsui Daisuke, Watanabe Isao, Suzuki Sadao, Watanabe Miki, Nakagawa-Senda Hiroko, Mikami Haruo, Nakamura Yohko, Arisawa Kokichi, Uemura Hirokazu, Kuriki Kiyonori, Takashima Naoyuki, Kadota Aya, Ikezaki Hiroaki, Murata Masayuki, Nakatochi Masahiro, Momozawa Yukihide, Kubo Michiaki, Wakai Kenji .  十二指腸潰瘍リスクに及ぼすPSCA遺伝子多型の影響(Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer) .  Journal of Epidemiology31 ( 1-2 ) 12 - 20   2021.2十二指腸潰瘍リスクに及ぼすPSCA遺伝子多型の影響(Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer)Reviewed International journal

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    <Highlight>●日本人集団においてPSCA遺伝子多型と十二指腸潰瘍/胃潰瘍のリスクとの関係、および環境要因との相互作用の評価を行った。●大規模日本人集団においてPSCA遺伝子多型rs2294008 Cアリルと十二指腸潰瘍のリスクとの関連が示された。●PSCA遺伝子多型rs2294008 Cアリルは年齢・性別・登録施設・喫煙習慣・飲酒習慣・H.pylori感染状況の環境要因とは独立して、十二指腸潰瘍のリスクと関連していた。(著者抄録)

  • Hishida Asahi, Nakatochi Masahiro, Tamura Takashi, Nagayoshi Mako, Okada Rieko, Kubo Yoko, Tsukamoto Mineko, Kadomatsu Yuka, Suzuki Sadao, Nishiyama Takeshi, Kuriyama Nagato, Watanabe Isao, Takezaki Toshiro, Nishimoto Daisaku, Kuriki Kiyonori, Arisawa Kokichi, Katsuura-Kamano Sakurako, Mikami Haruo, Kusakabe Miho, Oze Isao, Koyanagi Yuriko N., Nakamura Yasuyuki, Kadota Aya, Shimanoe Chisato, Tanaka Keitaro, Ikezaki Hiroaki, Murata Masayuki, Kubo Michiaki, Momozawa Yukihide, Takeuchi Kenji, Japan Multi-Institutional Collaborative Cohort(J-MICC)Study Group .  1000 Genomesの補完データに基づいた日本人集団における前立腺特異抗原の血清中濃度に関するゲノムワイド関連解析 日本多施設共同コホート研究(Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study) .  Nagoya Journal of Medical Science83 ( 1 ) 183 - 194   2021.21000 Genomesの補完データに基づいた日本人集団における前立腺特異抗原の血清中濃度に関するゲノムワイド関連解析 日本多施設共同コホート研究(Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study)Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:名古屋大学医学部  

    1000 Genomesプロジェクトのゲノムワイド関連解析(GWAS)補完データを利用し、日本人集団で血清中の前立腺特異抗原(PSA)濃度に影響を及ぼしている可能性がある遺伝子座の候補の発見を試みた。日本多施設共同コホート(J-MICC)研究から男性1216名分のGWAS補完データを取得して解析に用いた。血清PSA濃度を連続変量として扱い、一塩基多型(SNP)/遺伝子変異との関連性を線形Wald検定にて検定した。その結果、4番染色体上のスフィンゴミエリン合成酵素2(SGMS2)遺伝子のSNPであるrs10000006でゲノムワイド有意性が示され(P<5×10^-8)、さらに12、14、15染色体の上にある総計8種の変異にsuggestive levelの有意性が認められた(P<1×10^-6)。しかし、再現コホートとして前期集団とは無関係の男性2447名のデータをJ-MICCから取得して解析を繰り返したところ、上記のようなSGMS2のSNPと血中PSA濃度の関連性は再現されなかった。このようにPSA濃度に関連している遺伝子座の新規発見には失敗したものの、本研究ではPSAをコードしているKLK3遺伝子の重要性も確認されたことから、前立腺癌の診断に際し患者個別の遺伝情報を考慮することが将来可能になることを意味する結果が示された。

  • Usui Y, Matsuo K, Oze I, Ugai T, Koyanagi Y, Maeda Y, Ito H, Hishida A, Takeuchi K, Tamura T, Tsukamoto M, Kadomatsu Y, Hara M, Nishida Y, Shimoshikiryo I, Takezaki T, Ozaki E, Matsui D, Watanabe I, Suzuki S, Watanabe M, Nakagawa-Senda H, Mikami H, Nakamura Y, Arisawa K, Uemura H, Kuriki K, Takashima N, Kadota A, Ikezaki H, Murata M, Nakatochi M, Momozawa Y, Kubo M, Wakai K .  Impact of PSCA polymorphisms on the risk of duodenal ulcer. .  J Epidemiol31 ( 1 ) 12 - 20   2021Impact of PSCA polymorphisms on the risk of duodenal ulcer.Reviewed

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  • Usui Yoshiaki, Matsuo Keitaro, Oze Isao, Ugai Tomotaka, Koyanagi Yuriko, Maeda Yoshinobu, Ito Hidemi, Hishida Asahi, Takeuchi Kenji, Tamura Takashi, Tsukamoto Mineko, Kadomatsu Yuka, Hara Megumi, Nishida Yuichiro, Shimoshikiryo Ippei, Takezaki Toshiro, Ozaki Etsuko, Matsui Daisuke, Watanabe Isao, Suzuki Sadao, Watanabe Miki, Nakagawa-Senda Hiroko, Mikami Haruo, Nakamura Yohko, Arisawa Kokichi, Uemura Hirokazu, Kuriki Kiyonori, Takashima Naoyuki, Kadota Aya, Ikezaki Hiroaki, Murata Masayuki, Nakatochi Masahiro, Momozawa Yukihide, Kubo Michiaki, Wakai Kenji .  Impact of <i>PSCA</i> Polymorphisms on the Risk of Duodenal Ulcer .  Journal of Epidemiology31 ( 1 ) 12 - 20   2021

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    <p><b>Background:</b> While duodenal ulcer (DU) and gastric cancer (GC) are both <i>H. pylori</i> infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the <i>PSCA</i> rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in <i>PSCA</i> and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population.</p><p><b>Methods:</b> Six <i>PSCA</i> SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU.</p><p><b>Results:</b> <i>PSCA</i> rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18–1.51; <i>P</i> = 2.28 × 10<sup>−6</sup>) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit, and <i>H. pylori</i> status. On the other hand, we did not observe an association between the risk of GU and <i>PSCA</i> SNPs.</p><p><b>Conclusions:</b> Our study confirms an association between the <i>PSCA</i> rs2294008 C-allele and the risk of DU in a Japanese population.</p>

    DOI: 10.2188/jea.JE20190184

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  • Hishida A. .  Genome-Wide Association Study of Serum Prostate-Specific Antigen Levels Based on 1000 Genomes Imputed Data in Japanese: The Japan Multi-Institutional Collaborative Cohort Study .  Nagoya Journal of Medical Science83 ( 1 ) 183 - 194   2021

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    Language:Japanese   Publisher:Nagoya Journal of Medical Science  

    Prostate cancer is emerging as a significant global public health burden. The incidence and prevalence of prostate cancer has increased in Japan, as westernized lifestyles become more popular. Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with serum prostate-specific antigen (PSA) levels. One GWAS, which was based on classic GWAS microarray measurements, has been reported for Japanese so far. In the present study,we conducted a GWAS of serum PSA using 1000Genomes imputed GWAS data (n =1,216) from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, to detect candidate novel genetic loci that influence serum PSA levels in Japanese. The association of SNPs/genetic variants with serum PSA as a continuous variable was tested using the linear Wald test. SNP rs10000006 in SGMS2 (sphingomyelin synthase 2) on chromosome 4 had genome-wide significance (P <5×10∑8), and eight variants on three chromosomes (chromosomes 12, 14, 15) had genome-wide suggestive levels of significance (P <1×10∑6). With an independent data set from the J-MICC Shizuoka Study (n = 2,447), the association of the SGMS2 SNP with blood PSA levels was not replicated. Although our GWAS failed to detect novel loci associated with serum PSA levels in the Japanese cohort, it confirmed the significant effects of previously reported genetic loci on PSA levels in Japanese. Importantly, our results confirmed the significance of KLK3 SNPs also in Japanese, implying that consideration of individual genetic information in prostate cancer diagnosis may be possible in the future.

    DOI: 10.18999/nagjms.83.1.183

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  • Fujii Ryosuke, Hishida Asahi, Nishiyama Takeshi, Nakatochi Masahiro, Matsuo Keitaro, Ito Hidemi, Nishida Yuichiro, Shimanoe Chisato, Nakamura Yasuyuki, Turin Tanvir Chowdhury, Suzuki Sadao, Watanabe Miki, Ibusuki Rie, Takezaki Toshiro, Mikami Haruo, Nakamura Yohko, Ikezaki Hiroaki, Murata Masayuki, Kuriki Kiyonori, Kuriyama Nagato, Matsui Daisuke, Arisawa Kokichi, Katsuura-Kamano Sakurako, Tsukamoto Mineko, Tamura Takashi, Kubo Yoko, Kondo Takaaki, Momozawa Yukihide, Kubo Michiaki, Takeuchi Kenji, Wakai Kenji .  Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study .  Journal of Epidemiology32 ( 11 ) 483 - 488   2021Reviewed International journal

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    <p><b>Background:</b> Inflammation is thought to be a risk factor for kidney disease. However, whether inflammatory status is either a cause or an outcome of chronic kidney disease remains controversial. We aimed to investigate the causal relationship between high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) using Mendelian randomization (MR) approaches.</p><p><b>Methods:</b> A total of 10,521 participants of the Japan Multi-institutional Collaborative Cohort Study was analyzed in this study. We used two-sample MR approaches (the inverse-variance weighted (IVW), the weighted median (WM), and the MR-Egger method) to estimate the effect of genetically determined hs-CRP on kidney function. We selected four and three hs-CRP associated single nucleotide polymorphisms (SNPs) as two instrumental variables (IV): IV<sub>CRP</sub> and IV<sub>Asian</sub>, based on SNPs previously identified in European and Asian populations. IV<sub>CRP</sub> and IV<sub>Asian</sub> explained 3.4% and 3.9% of the variation in hs-CRP, respectively.</p><p><b>Results:</b> Using the IV<sub>CRP</sub>, genetically determined hs-CRP was not significantly associated with eGFR in the IVW and the WM methods (estimate per 1 unit increase in ln(hs-CRP), 0.000; 95% confidence interval [CI], −0.019 to 0.020 and −0.003; 95% CI, −0.019 to 0.014, respectively). For IV<sub>Asian</sub>, we found similar results using the IVW and the WM methods (estimate, 0.005; 95% CI, −0.020 to 0.010 and −0.004; 95% CI, −0.020 to 0.012, respectively). The MR-Egger method also showed no causal relationships between hs-CRP and eGFR (IV<sub>CRP</sub>: −0.008; 95% CI, −0.058 to 0.042; IV<sub>Asian</sub>: 0.001; 95% CI, −0.036 to 0.036).</p><p><b>Conclusion:</b> Our two-sample MR analyses with different IVs did not support a causal effect of hs-CRP on eGFR.</p>

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  • Suzuki T. .  A Genome-wide Association Study on Confection Consumption in a Japanese Population-the Japan Multi-Institutional Collaborative Cohort study .  British Journal of Nutrition126 ( 12 ) 1 - 9   2021Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:British Journal of Nutrition  

    Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social or environmental factors. Previous studies suggested that genetic variants within sweet taste receptor genes family were associated with sweet taste perception and the intake of sweet foods. The aim of this study was to conduct a genome-wide association study (GWAS) to find genetic variations that affect confection consumption in a Japanese population. We analysed GWAS data on confection consumption using 14 073 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a semi-quantitative FFQ to estimate food intake that was validated previously. Association of the imputed variants with confection consumption was performed by linear regression analysis with adjustments for age, sex, total energy intake and principal component analysis components 1-3. Furthermore, the analysis was repeated adjusting for alcohol intake (g/d) in addition to the above-described variables. We found 418 SNP located in 12q24 that were associated with confection consumption. SNP with the ten lowest P-values were located on nine genes including at the BRAP, ACAD10 and aldehyde dehydrogenase 2 regions on 12q24.12-13. After adjustment for alcohol intake, no variant was associated with confections intake with genome-wide significance. In conclusion, we found a significant number of SNP located on 12q24 genes that were associated with confections intake before adjustment for alcohol intake. However, all of them lost statistical significance after adjustment for alcohol intake.

    DOI: 10.1017/S0007114521000684

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  • Nindita Yora, Nakatochi Masahiro, Ibusuki Rie, Shimoshikiryo Ippei, Nishimoto Daisaku, Shimatani Keiichi, Takezaki Toshiro, Ikezaki Hiroaki, Murata Masayuki, Hara Megumi, Nishida Yuichiro, Tamura Takashi, Hishida Asahi, Nagayoshi Mako, Okada Rieko, Matsuo Keitaro, Ito Hidemi, Mikami Haruo, Nakamura Yohko, Otani Takahiro, Suzuki Sadao, Koyama Teruhide, Ozaki Etsuko, Kuriki Kiyonori, Takashima Naoyuki, Miyagawa Naoko, Arisawa Kokichi, Katsuura-Kamano Sakurako, Momozawa Yukihide, Kubo Michiaki, Takeuchi Kenji, Wakai Kenji .  Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-cholesterol Levels in J-MICC Study Participants .  Journal of Epidemiology33 ( 4 ) 193 - 200   2021Reviewed International journal

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Epidemiological Association  

    <p><b>Background:</b> Environmental and genetic factors are suggested to exhibit factor-based association with HDL-cholesterol (HDL-C) levels. However, the population-based effects of environmental and genetic factors have not been compared clearly. We conducted a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study to evaluate the population-based impact of smoking, drinking, and genetic factors on low HDL-C.</p><p><b>Methods:</b> Data from 11,498 men and women aged 35–69 years were collected for a genome-wide association study (GWAS). Sixty-five HDL-C-related SNPs with genome-wide significance (<i>P</i> < 5 × 10<sup>−8</sup>) were selected from the GWAS catalog, of which seven representative SNPs were defined, and the population-based impact was estimated using population attributable fraction (PAF).</p><p><b>Results:</b> We found that smoking, drinking, daily activity, habitual exercise, egg intake, BMI, age, sex, and the SNPs <i>CETP</i> rs3764261, <i>APOA5</i> rs662799, <i>LIPC</i> rs1800588, <i>LPL</i> rs328, <i>ABCA1</i> rs2575876, <i>LIPG</i> rs3786247, and <i>APOE</i> rs429358 were associated with HDL-C levels. The gene-environmental interactions on smoking and drinking were not statistically significant. The PAF for low HDL-C was the highest in men (63.2%) and in rs3764261 (31.5%) of the genetic factors, and the PAFs of smoking and drinking were 23.1% and 41.8%, respectively.</p><p><b>Conclusion:</b> The present study showed that the population-based impact of genomic factor <i>CETP</i> rs3764261 for low HDL-C was higher than that of smoking and lower than that of drinking.</p>

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  • Koyama T. .  Effect of underlying cardiometabolic diseases on the association between sedentary time and all-cause mortality in a large japanese population: A cohort analysis based on the j-micc study .  Journal of the American Heart Association10 ( 13 ) e018293   2021Reviewed International journal

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    BACKGROUND: This study aimed to determine the association between sedentary time and mortality with regard to leisure-time physical activity with or without cardiometabolic diseases such as hypertension, dyslipidemia, and diabetes mellitus. METHODS AND RESULTS: Using data from the J-MICC (Japan Multi-Institutional Collaborative Cohort) Study, 64 456 participants (29 022 men, 35 434 women) were analyzed. Hazard ratios (HRs) and 95% CIs were used to characterize the relative risk of all-cause mortality to evaluate its association with sedentary time (categorical variables: <5, 5 to <7, 7 to <9, ≥9 h/d and 2-hour increments in exposure) according to the self-reported hypertension, dyslipidemia, and diabetes mellitus using a Cox proportional hazards model. A total of 2257 participants died during 7.7 years of follow-up. The corresponding HRs for each 2-hour increment in sedentary time among participants with all factors, no factors, hypertension, dyslipidemia, and diabetes mellitus were 1.153 (95% CI, 1.114–1.194), 1.125 (95% CI, 1.074–1.179), 1.202 (95% CI, 1.129–1.279), 1.176 (95% CI, 1.087–1.273), and 1.272 (95% CI, 1.159–1.396), respectively. Furthermore, when analyzed according to the combined different factors (hypertension, dyslipidemia, and diabetes mellitus), HRs increased with each additional factor, and participants reporting all 3 conditions had the highest HR of 1.417 (95% CI, 1.162–1.728) independently of leisure-time metabolic equivalents. CONCLUSIONS: The association between sedentary time and increased mortality is stronger among patients with hypertension, dyslipidemia, and diabetes mellitus regardless of leisure-time physical activity in a large Japanese population.

    DOI: 10.1161/JAHA.120.018293

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  • Hara Megumi, Nishida Yuichiro, Tanaka Keitaro, Shimanoe Chisato, Koga Kayoko, Furukawa Takuma, Higaki Yasuki, Shinchi Koichi, Ikezaki Hiroaki, Murata Masayuki, Takeuchi Kenji, Tamura Takashi, Hishida Asahi, Tsukamoto Mineko, Kadomatsu Yuka, Matsuo Keitaro, Oze Isao, Mikami Haruo, Kusakabe Miho, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Nakagawa-Senda Hiroko, Matsui Daisuke, Koyama Teruhide, Kuriki Kiyonori, Takashima Naoyuki, Nakamura Yasuyuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Wakai Kenji .  Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study .  Journal of Epidemiologyadvpub ( 0 ) 285 - 293   2021Reviewed International journal

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    <p><b>Background:</b> Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function.</p><p><b>Methods:</b> We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m<sup>2</sup>. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied.</p><p><b>Results:</b> After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (<i>P</i> for trend MVPA <0.0001) and lower eGFR (<i>P</i> for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68–0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52–2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD.</p><p><b>Conclusions:</b> These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.</p>

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  • Takeuchi K., Naito M., Kawai S., Tsukamoto M., Kadomatsu Y., Kubo Y., Okada R., Nagayoshi M., Tamura T., Hishida A., Nakatochi M., Sasakabe T., Hashimoto S., Eguchi H., Momozawa Y., Ikezaki H., Murata M., Furusyo N., Tanaka K., Hara M., Nishida Y., Matsuo K., Ito H., Oze I., Mikami H., Nakamura Y., Kusakabe M., Takezaki T., Ibusuki R., Shimoshikiryo I., Suzuki S., Nishiyama T., Watanabe M., Koyama T., Ozaki E., Watanabe I., Kuriki K., Kita Y., Ueshima H., Matsui K., Arisawa K., Uemura H., Katsuura-Kamano S., Nakamura S., Narimatsu H., Hamajima N., Tanaka H., Wakai K. .  Study profile of the japan multi-institutional collaborative cohort (J-micc) study .  Journal of Epidemiology31 ( 12 ) 660 - 668   2021

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    Background: The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene–environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants. Methods: The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history and collected peripheral blood samples. Results: The baseline survey included 92,610 adults (mean age: 55.2 [standard deviation, 9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65–69 years for men and 60–64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women. Conclusions: The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.

    DOI: 10.2188/jea.JE20200147

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  • Tamura T. .  Association between plasma levels of homocysteine, folate, and vitamin B<inf>12</inf>, and dietary folate intake and hypertension in a cross-sectional study .  Scientific Reports10 ( 1 ) 18499   2020.12

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    Publisher:Scientific Reports  

    DOI: 10.1038/s41598-020-75267-3

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  • Shimoshikiryo I. .  Association between alcohol intake pattern and metabolic syndrome components and simulated change by alcohol intake reduction: A cross-sectional study from the Japan Multi-Institutional Collaborative Cohort Study .  Alcohol89   129 - 138   2020.12Reviewed International journal

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    DOI: 10.1016/j.alcohol.2020.09.002

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  • Koyama Teruhide, Kuriyama Nagato, Ozaki Etsuko, Tomida Satomi, Uehara Ritei, Nishida Yuichiro, Shimanoe Chisato, Hishida Asahi, Tamura Takashi, Tsukamoto Mineko, Kadomatsu Yuka, Oze Isao, Matsuo Keitaro, Mikami Haruo, Nakamura Yohko, Ibusuki Rie, Takezaki Toshiro, Suzuki Sadao, Nishiyama Takeshi, Kuriki Kiyonori, Takashima Naoyuki, Kadota Aya, Uemura Hirokazu, Katsuura-Kamano Sakurako, Ikezaki Hiroaki, Murata Masayuki, Takeuchi Kenji, Wakai Kenji .  日本人の大規模コホートにおいて座位時間は心血管代謝性疾患と相関する 横断研究(Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study) .  Journal of Atherosclerosis and Thrombosis27 ( 10 ) 1097 - 1107   2020.10日本人の大規模コホートにおいて座位時間は心血管代謝性疾患と相関する 横断研究(Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study)Reviewed International journal

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    地域住民コホート研究に参加した一般被験者62754名(男性27930名、女性34824名)を対象に、座位時間と心血管代謝性疾患の関連について検討した。対象は生活習慣病予防に関する分子疫学研究である日本多施設共同コホート研究(J-MICC Study)に参加した35〜69歳の被験者で、虚血性心疾患と脳卒中の既往者は除外した。質問票を用いて、1日あたりの座位時間と高血圧症、脂質異常症、糖尿病の既往の有無を調査した。男性で座位時間が5時間未満は9529名(34.1%)、5〜7時間は5458名(19.5%)、7〜9時間は4491名(16.1%)、9時間以上は8452名(30.3%)であった。女性はそれぞれ14121名(40.5%)、8727名(25.1%)、5717名(16.4%)、6261名(18.0%)であった。男性で座位時間と高血圧症および糖尿病の間に有意な関連を認めた。男性と女性のいずれも座位時間と脂質異常症が関連した。特に60〜69歳の年齢層では、座位時間の増加に伴い血圧、中性脂肪、非高比重リポ蛋白コレステロール(non-HDL-C)が増加し、HDL-Cが低下する傾向を認めた。

  • Shimatani Keiichi, Ito Hidemi, Matsuo Keitaro, Tajima Kazuo, Takezaki Toshiro .  日本人喫煙者におけるたばこタールの累積曝露量と肺癌リスク(Cumulative cigarette tar exposure and lung cancer risk among Japanese smokers) .  Japanese Journal of Clinical Oncology50 ( 9 ) 1009 - 1017   2020.9日本人喫煙者におけるたばこタールの累積曝露量と肺癌リスク(Cumulative cigarette tar exposure and lung cancer risk among Japanese smokers)Reviewed International journal

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    たばこタールの累積曝露による肺癌リスクを調べるため、日本人喫煙者を対象とする症例対照研究を実施した。1993〜1998年に行われた日米共同肺癌研究のデータから、組織学的に肺癌と診断された症例群282名、院内対照(HC)群162名、地域在住対照(CC)群227名を本研究に組み入れた。累積タール濃度は、銘柄別の年間タール濃度に喫煙年数を乗じて算出した。累積タール曝露による肺癌のオッズ比と95%信頼区間はロジスティックモデルを用いて推定した。喫煙者の割合は症例群が両対照群よりも有意に高く、HC群はCC群よりも僅かに高かった。タールの累積曝露量は症例群が最も多く(68.8±41.6×10^5mg)、HC群が最も少なかった(46.5±24.2×10^5mg)。肺癌のオッズ比は、タールの累積曝露量が低い場合(1〜59.8×10^5mg)と高い場合(>59.8×10^5mg)のいずれも統計学的に有意であり、増加傾向にあった(P<0.001)。層別解析の結果、吸入量、フィルター付きタバコの喫煙期間、組織型にかかわらず、タールの累積曝露量が多い対象者ではオッズ比が高いことが示された。

  • Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, Ugai T, Kasugai Y, Hishida A, Takeuchi K, Okada R, Kubo Y, Shimanoe C, Tanaka K, Ikezaki H, Murata M, Takezaki T, Nishimoto D, Kuriyama N, Ozaki E, Suzuki S, Watanabe M, Mikami H, Nakamura Y, Uemura H, Katsuura-Kamano S, Kuriki K, Kita Y, Naoyuki T, Nagino M, Momozawa Y, Kubo M, Wakai K .  Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study. .  J Epidemiol   doi: 10.2188/jea.JE20190296.   2020Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study.Reviewed

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  • Shimoshikiryo I, Ibusuki R, Shimatani K, Nishimoto D, Takezaki T, Nishida Y, Shimanoe C, Hishida A, Tamura T, Okada R, Kubo Y, Ozaki E, Matsui D, Suzuki S, Nakagawa-Senda H, Kuriki K, Kita Y, Takashima N, Arisawa K, Uemura H, Ikezaki H, Furusyo N, Oze I, Koyanagi YN, Mikami H, Nakamura Y, Naito M, Wakai K .  Association between alcohol intake pattern and metabolic syndrome components and simulated change by alcohol intake reduction: A cross-sectional study from the Japan Multi-Institutional Collaborative Cohort Study. .  Alcohol89   129 - 138   2020Association between alcohol intake pattern and metabolic syndrome components and simulated change by alcohol intake reduction: A cross-sectional study from the Japan Multi-Institutional Collaborative Cohort Study.Reviewed

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  • Okada R, Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Tamura T, Hishida A, Ikezaki H, Furusyo N, Tanaka K, Hara M, Suzuki S, Watanabe M, Takezaki T, Nishimoto D, Matsui D, Watanabe I, Kuriki K, Takashima N, Nakamura Y, Katsuura-Kamano S, Arisawa K, Mikami H, Nakamura Y, Oze I, Koyanagi YN, Naito M, Wakai K .  Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study. .  J Hum Hypertens34 ( 2 ) 125 - 131   2020Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study.Reviewed

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  • Tamura T, Kuriyama N, Koyama T, Ozaki E, Matsui D, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Hishida A, Sasakabe T, Kawai S, Naito M, Takashima N, Kadota A, Tanaka K, Hara M, Suzuki S, Nakagawa-Senda H, Takezaki T, Shimoshikiryo I, Ikezaki H, Murata M, Oze I, Ito H, Mikami H, Nakamura Y, Kuriki K, Arisawa K, Uemura H, Takeuchi K, Wakai K .  Association between plasma levels of homocysteine, folate, and vitamin B(12), and dietary folate intake and hypertension in a cross-sectional study. .  Sci Rep10 ( 1 ) 18499   2020Association between plasma levels of homocysteine, folate, and vitamin B(12), and dietary folate intake and hypertension in a cross-sectional study.Reviewed

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  • Arisawa K, Katsuura-Kamano S, Uemura H, Tien NV, Hishida A, Tamura T, Kubo Y, Tsukamoto M, Tanaka K, Hara M, Takezaki T, Nishimoto D, Koyama T, Ozaki E, Suzuki S, Nishiyama T, Kuriki K, Kadota A, Takashima N, Ikezaki H, Murata M, Oze I, Matsuo K, Mikami H, Nakamura Y, Takeuchi K, Wakai K .  Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study. .  Nutrients12 ( 6 ) 1605   2020Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study.Reviewed

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  • Nishida Y, Hachiya T, Hara M, Shimanoe C, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Tsukamoto M, Kadomatsu Y, Oze I, Koyanagi YN, Kuriyama N, Koyama T, Ibusuki R, Takezaki T, Ikezaki H, Furusyo N, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Suzuki S, Nakagawa-Senda H, Kuriki K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K .  The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population. .  J Lipid Res61 ( 1 ) 86 - 94   2020The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.Reviewed

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  • Takeuchi K, Naito M, Kawai S, Tsukamoto M, Kadomatsu Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Nakatochi M, Sasakabe T, Hashimoto S, Eguchi H, Momozawa Y, Ikezaki H, Murata M, Furusyo N, Tanaka K, Hara M, Nishida Y, Matsuo K, Ito H, Oze I, Mikami H, Nakamura Y, Kusakabe M, Takezaki T, Ibusuki R, Shimoshikiryo I, Suzuki S, Nishiyama T, Watanabe M, Koyama T, Ozaki E, Watanabe I, Kuriki K, Kita Y, Ueshima H, Matsui K, Arisawa K, Uemura H, Katsuura-Kamano S, Nakamura S, Narimatsu H, Hamajima N, Tanaka H, Wakai K .  Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. .  J Epidemiol   doi: 10.2188/jea.JE20200147.   2020Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study.Reviewed

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  • Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Shimizu S, Higashino T, Koyama T, Hishida A, Kuriki K, Watanabe M, Shimizu T, Ooyama K, Ooyama H, Nagase M, Hidaka Y, Matsui D, Tamura T, Nishiyama T, Shimanoe C, Katsuura-Kamano S, Takashima N, Shirai Y, Kawaguchi M, Takao M, Sugiyama R, Takada Y, Nakamura T, Nakashima H, Tsunoda M, Danjoh I, Hozawa A, Hosomichi K, Toyoda Y, Kubota Y, Takada T, Suzuki H, Stiburkova B, Major TJ, Merriman TR, Kuriyama N, Mikami H, Takezaki T, Matsuo K, Suzuki S, Hosoya T, Kamatani Y, Kubo M, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H .  Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients. .  Ann Rheum Dis79 ( 5 ) 657 - 665   2020Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.Reviewed

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  • Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, Sakamoto H, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Matsuyama M, Sasahira N, Morimoto M, Kobayashi S, Fukushima T, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Adachi Y, Okuda M, Osaki T, Kamiya S, Wang C, Hara K, Shimizu Y, Miyamoto T, Hayashi Y, Ebi H, Kohmoto T, Imoto I, Kasugai Y, Murakami Y, Akiyama M, Ishigaki K, Matsuda K, Hirata M, Shimada K, Okusaka T, Kawaguchi T, Takahashi M, Watanabe Y, Kuriki K, Kadota A, Okada R, Mikami H, Takezaki T, Suzuki S, Yamaji T, Iwasaki M, Sawada N, Goto A, Kinoshita K, Fuse N, Katsuoka F, Shimizu A, Nishizuka SS, Tanno K, Suzuki K, Okada Y, Horikoshi M, Yamauchi T, Kadowaki T, Yu H, Zhong J, Amundadottir LT, Doki Y, Ishii H, Eguchi H, Bogumil D, Haiman CA, Le Marchand L, Mori M, Risch H, Setiawan VW, Tsugane S, Wakai K, Yoshida T, Matsuda F, Kubo M, Kikuchi S, Matsuo K .  Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. .  Nat Commun11 ( 1 ) 3175   2020Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.Reviewed

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  • Mizuma K, Amitani M, Mizuma M, Kawazu S, Sloan RA, Ibusuki R, Takezaki T, Owaki T .  Clarifying differences in viewpoints between multiple healthcare professionals during discharge planning assessments when discharging patients from a long-term care hospital to home. .  Eval Program Plann82   101848   2020Clarifying differences in viewpoints between multiple healthcare professionals during discharge planning assessments when discharging patients from a long-term care hospital to home.Reviewed

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  • Suzuki H, Nakamura Y, Matsuo K, Imaeda N, Goto C, Narita A, Shimizu A, Takashima N, Matsui K, Miura K, Nakatochi M, Hishida A, Tamura T, Kadomatsu Y, Okada R, Nishida Y, Shimanoe C, Nishimoto D, Takezaki T, Oze I, Ito H, Ikezaki H, Murata M, Matsui D, Ozaki E, Mikami H, Nakamura Y, Suzuki S, Watanabe M, Arisawa K, Uemura H, Kuriki K, Momozawa Y, Kubo M, Kita Y, Takeuchi K, Wakai K .  A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern. .  Eur J Clin Nutr   doi: 10.1038/s41430-020-00823-z.   2020A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern.Reviewed

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  • Moosazadeh M, Takezaki T, Saeedi M, Kheradmand M .  Association between gravidity and risk of metabolic syndrome: Results of Tabari cohort study. .  Diabetes Metab Syndr14 ( 5 ) 843 - 847   2020Association between gravidity and risk of metabolic syndrome: Results of Tabari cohort study.Reviewed

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  • Suzuki T, Nakamura Y, Matsuo K, Oze I, Doi Y, Narita A, Shimizu A, Imaeda N, Goto C, Matsui K, Nakatochi M, Miura K, Takashima N, Kuriki K, Shimanoe C, Tanaka K, Ikezaki H, Murata M, Ibusuki R, Takezaki T, Koyanagi Y, Ito H, Matsui D, Koyama T, Mikami H, Nakamura Y, Suzuki S, Nishiyama T, Katsuura-Kamano S, Arisawa K, Takeuchi K, Tamura T, Okada R, Kubo Y, Momozawa Y, Kubo M, Kita Y, Wakai K .  A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study. .  Eur J Clin Nutr   doi: 10.1038/s41430-020-00702-7.   2020A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study.Reviewed

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  • Shimatani K, Ito H, Matsuo K, Tajima K, Takezaki T .  Cumulative cigarette tar exposure and lung cancer risk among Japanese smokers. .  Jpn J Clin Oncol50 ( 9 ) 1009 - 1017   2020Cumulative cigarette tar exposure and lung cancer risk among Japanese smokers.Reviewed

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  • Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Shimizu S, Higashino T, Koyama T, Hishida A, Kuriki K, Watanabe M, Shimizu T, Ooyama K, Ooyama H, Nagase M, Hidaka Y, Matsui D, Tamura T, Nishiyama T, Shimanoe C, Katsuura-Kamano S, Takashima N, Shirai Y, Kawaguchi M, Takao M, Sugiyama R, Takada Y, Nakamura T, Nakashima H, Tsunoda M, Danjoh I, Hozawa A, Hosomichi K, Toyoda Y, Kubota Y, Takada T, Suzuki H, Stiburkova B, Major TJ, Merriman TR, Kuriyama N, Mikami H, Takezaki T, Matsuo K, Suzuki S, Hosoya T, Kamatani Y, Kubo M, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H .  Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients. .  Ann Rheum Dis79 ( 5 ) 657 - 665   2020Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.Reviewed

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  • Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, Sakamoto H, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Matsuyama M, Sasahira N, Morimoto M, Kobayashi S, Fukushima T, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Adachi Y, Okuda M, Osaki T, Kamiya S, Wang C, Hara K, Shimizu Y, Miyamoto T, Hayashi Y, Ebi H, Kohmoto T, Imoto I, Kasugai Y, Murakami Y, Akiyama M, Ishigaki K, Matsuda K, Hirata M, Shimada K, Okusaka T, Kawaguchi T, Takahashi M, Watanabe Y, Kuriki K, Kadota A, Okada R, Mikami H, Takezaki T, Suzuki S, Yamaji T, Iwasaki M, Sawada N, Goto A, Kinoshita K, Fuse N, Katsuoka F, Shimizu A, Nishizuka SS, Tanno K, Suzuki K, Okada Y, Horikoshi M, Yamauchi T, Kadowaki T, Yu H, Zhong J, Amundadottir LT, Doki Y, Ishii H, Eguchi H, Bogumil D, Haiman CA, Le Marchand L, Mori M, Risch H, Setiawan VW, Tsugane S, Wakai K, Yoshida T, Matsuda F, Kubo M, Kikuchi S, Matsuo K .  Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. .  Nat Commun11 ( 1 ) 3175   2020Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.Reviewed

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  • Koyama T, Kuriyama N, Ozaki E, Tomida S, Uehara R, Nishida Y, Shimanoe C, Hishida A, Tamura T, Tsukamoto M, Kadomatsu Y, Oze I, Matsuo K, Mikami H, Nakamura Y, Ibusuki R, Takezaki T, Suzuki S, Nishiyama T, Kuriki K, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Ikezaki H, Murata M, Takeuchi K, Wakai K .  Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study. .  J Atheroscler Thromb27 ( 10 ) 1097 - 1107   2020Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study.Reviewed

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  • Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, Ugai T, Kasugai Y, Hishida A, Takeuchi K, Okada R, Kubo Y, Shimanoe C, Tanaka K, Ikezaki H, Murata M, Takezaki T, Nishimoto D, Kuriyama N, Ozaki E, Suzuki S, Watanabe M, Mikami H, Nakamura Y, Uemura H, Katsuura-Kamano S, Kuriki K, Kita Y, Naoyuki T, Nagino M, Momozawa Y, Kubo M, Wakai K .  Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study. .  J Epidemiol   doi: 10.2188/jea.JE20190296.   2020Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study.Reviewed

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  • Arisawa K, Katsuura-Kamano S, Uemura H, Tien NV, Hishida A, Tamura T, Kubo Y, Tsukamoto M, Tanaka K, Hara M, Takezaki T, Nishimoto D, Koyama T, Ozaki E, Suzuki S, Nishiyama T, Kuriki K, Kadota A, Takashima N, Ikezaki H, Murata M, Oze I, Matsuo K, Mikami H, Nakamura Y, Takeuchi K, Wakai K .  Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study. .  Nutrients12 ( 6 ) 1605   2020Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study.Reviewed

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  • Nishida Y, Hachiya T, Hara M, Shimanoe C, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Tsukamoto M, Kadomatsu Y, Oze I, Koyanagi YN, Kuriyama N, Koyama T, Ibusuki R, Takezaki T, Ikezaki H, Furusyo N, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Suzuki S, Nakagawa-Senda H, Kuriki K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K .  The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population. .  J Lipid Res   doi: 10.1194/jlr.P091546   2019.11The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.Reviewed

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  • Okada R, Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Tamura T, Hishida A, Ikezaki H, Furusyo N, Tanaka K, Hara M, Suzuki S, Watanabe M, Takezaki T, Nishimoto D, Matsui D, Watanabe I, Kuriki K, Takashima N, Nakamura Y, Katsuura-Kamano S, Arisawa K, Mikami H, Nakamura Y, Oze I, Koyanagi YN, Naito M, Wakai K .  Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study. .  J Hum Hypertens   doi: 10.1038/s41371-019-0230-y   2019.9Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study.Reviewed

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  • Nishiyama T. .  Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population .  Sleep42 ( 6 )   2019.6

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  • Iwasaki Y. .  Associations of nutrient patterns with the prevalence of metabolic syndrome: Results from the baseline data of the Japan multi-institutional collaborative cohort study .  Nutrients11 ( 5 )   2019.5Reviewed International journal

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  • Iwasaki Y, Arisawa K, Katsuura-Kamano S, Uemura H, Tsukamoto M, Kadomatsu Y, Okada R, Hishida A, Tanaka K, Hara M, Takezaki T, Shimatani K, Ozaki E, Koyama T, Suzuki S, Nakagawa-Senda H, Kuriki K, Miyagawa N, Kadota A, Ikezaki H, Furusyo N, Oze I, Ito H, Mikami H, Nakamura Y, Wakai K .  Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study. .  Nutrients11 ( 5 ) doi: 10.3390/nu11050990   2019.4Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study.Reviewed

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  • Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin TC, Naoyuki T, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S .  Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population. .  Sleep   doi: 10.1093/sleep/zsz046   2019.2Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population.Reviewed

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  • Uemura H, Katsuura-Kamano S, Iwasaki Y, Arisawa K, Hishida A, Okada R, Tamura T, Kubo Y, Ito H, Oze I, Shimanoe C, Nishida Y, Nakamura Y, Takashima N, Suzuki S, Nakagawa-Senda H, Nishimoto D, Takezaki T, Mikami H, Nakamura Y, Furusyo N, Ikezaki H, Ozaki E, Koyama T, Kuriki K, Endoh K, Naito M, Wakai K .  Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population. .  Endocrine64 ( 3 ) 552 - 563   2019.1Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population.Reviewed

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  • Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Sakurai-Yageta M, Nakaya N, Shimizu A, Nishizuka SS, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Takezaki T, Suzuki S, Naito M, Wakai K, Kamatani Y, Momozawa Y, Murakami Y, Inazawa J, Nakamura Y, Kubo M, Katagiri T, Miki Y .  Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. .  Sci Rep9   17332   2019Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population.Reviewed

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  • Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, Hirata M, Okada R, Kawai S, Kawaguchi M, Nishida Y, Shimanoe C, Ibusuki R, Takezaki T, Nakajima M, Takao M, Ozaki E, Matsui D, Nishiyama T, Suzuki S, Takashima N, Kita Y, Endoh K, Kuriki K, Uemura H, Arisawa K, Oze I, Matsuo K, Nakamura Y, Mikami H, Tamura T, Nakashima H, Nakamura T, Kato N, Matsuda K, Murakami Y, Matsubara T, Naito M, Kubo M, Kamatani Y, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H .  Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. .  Commun Biol2   115   2019Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.Reviewed

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  • Kawamura Y, Nakaoka H, Nakayama A, Okada Y, Yamamoto K, Higashino T, Sakiyama M, Shimizu T, Ooyama H, Ooyama K, Nagase M, Hidaka Y, Shirahama Y, Hosomichi K, Nishida Y, Shimoshikiryo I, Hishida A, Katsuura-Kamano S, Shimizu S, Kawaguchi M, Uemura H, Ibusuki R, Hara M, Naito M, Takao M, Nakajima M, Iwasawa S, Nakashima H, Ohnaka K, Nakamura T, Stiburkova B, Merriman TR, Nakatochi M, Ichihara S, Yokota M, Takada T, Saitoh T, Kamatani Y, Takahashi A, Arisawa K, Takezaki T, Tanaka K, Wakai K, Kubo M, Hosoya T, Ichida K, Inoue I, Shinomiya N, Matsuo H .  Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. .  Ann Rheum Dis78   1430 - 1437   2019Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.Reviewed

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  • Fujii R, Hishida A, Nakatochi M, Furusyo N, Murata M, Tanaka K, Shimanoe C, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Takezaki T, Shimoshikiryo I, Arisawa K, Katsuura-Kamano S, Takashima N, Turin TC, Kuriki K, Endoh K, Mikami H, Nakamura Y, Oze I, Ito H, Kubo M, Momozawa Y, Kondo T, Naito M, Wakai K .  Association of genetic risk score and chronic kidney disease in a Japanese population. .  Nephrology (Carlton)   doi: 10.1111/nep.13479.   2018.8Association of genetic risk score and chronic kidney disease in a Japanese population.Reviewed

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  • Miyagawa N, Okuda N, Nakagawa H, Takezaki T, Nishi N, Takashima N, Fujiyoshi A, Ohkubo T, Kadota A, Okamura T, Ueshima H, Okayama A, Miura K .  Socioeconomic Status Associated With Urinary Sodium and Potassium Excretion in Japan: NIPPON DATA2010. .  J Epidemiol28 ( Supplement_III ) S29 - S34   2018.5Reviewed

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    BACKGROUND: Although socioeconomic status (SES) may affect food and nutrient intakes, few studies have reported on sodium (Na) and potassium (K) intakes among individuals with various SESs in Japan. We investigated associations of SES with Na and K intake levels using urinary specimens in a representative Japanese population. METHODS: This was a cross-sectional study of 2,560 men and women (the NIPPON DATA2010 cohort) who participated in the National Health and Nutrition Survey Japan in 2010. Casual urine was used to calculate estimated excretion in 24-hour urinary Na (E24hr-Na) and K (E24hr-K). The urinary sodium-to-potassium (Na/K) ratio was calculated from casual urinary electrolyte values. An analysis of covariance was performed to investigate associations of aspects of SES, including equivalent household expenditure (EHE), educational attainment, and job category, with E24hr-Na, E24hr-K, and the Na/K ratio for men and women separately. A stratified analysis was performed on educational attainment and the job category for younger (<65 years) and older (>/=65 years) participants. RESULTS: In men and women, average E24hr-Na was 176.2 mmol/day and 172.3, average E24hr-K was 42.5 and 41.3, and the average Na/K ratio was 3.61 and 3.68, respectively. Lower EHE was associated with a higher Na/K ratio in women and lower E24hr-K in men and women. A shorter education was associated with a higher Na/K ratio in women and younger men, and lower E24hr-K in older men and women. CONCLUSION: Lower EHE and a shorter education were associated with a lower K intake and higher Na/K ratio estimated from casual urine specimens in Japanese men and women.

    DOI: 10.2188/jea.JE20170253

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  • Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Leveque K, Nagayama S, Mimori K, Mori M, Ishii H, Inazawa J, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Kubo M, Matsuda K .  GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12. .  Carcinogenesis   pii: 4868136 - pii: 4868136   2018.2GWAS Identifies Two Novel Colorectal Cancer Loci at 16q24.1 and 20q13.12.

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  • Tsuji Masayoshi, Okamura Tomonori, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, Arima Hisatomi, Ohkubo Takayoshi, Nakamura Koshi, Takezaki Toshiro, Sakata Kiyomi, Okuda Nagako, Nishi Nobuo, Kadota Aya .  Socioeconomic Status and Knowledge of Cardiovascular Risk Factors: NIPPON DATA2010 .  Journal of Epidemiology28 ( 0 ) S46 - S52   2018Reviewed

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    <p><b>Background:</b> The relationship between socioeconomic status (SES) and knowledge of cardiovascular risk factors remains unknown in a general Japanese population.</p><p><b>Methods:</b> Of 8,815 participants from 300 randomly selected areas throughout Japan, 2,467 participants who were free of cardiovascular disease and who provided information on SES in the National Health and Nutrition Survey of Japan 2010 were enrolled in this cross-sectional analysis. SES was classified according to the employment status, length of education, marital and living statuses, and equivalent household expenditure (EHE). Outcomes were ignorance of each cardiovascular risk factor (hypertension, diabetes, hypercholesterolemia, low high-density lipoprotein [HDL] cholesterol, arrhythmia, and smoking) and insufficient knowledge (number of correct answers <4 out of 6).</p><p><b>Results:</b> A short education and low EHE were significantly associated with a greater ignorance of most cardiovascular risk factors. A short education (<10 years) was also associated with insufficient knowledge of overall cardiovascular risk factors: age- and sex-adjusted odds ratios (OR) were 1.92 (95% confidence interval [CI], 1.51–2.45) relative to participants with ≥13 years of education. Low EHE was also associated with insufficient knowledge (age- and sex-adjusted OR 1.24; 95% CI, 1.01–1.51 for the lowest quintile vs the upper 4 quintiles). These relationships remained significant, even after further adjustments for regular exercise, smoking, weekly alcohol consumption, body mass index, hypertension, diabetes mellitus, hypercholesterolemia, and low HDL cholesterol.</p><p><b>Conclusion:</b> Participants with a short education and low EHE were more likely to have less knowledge of cardiovascular risk factors.</p>

    DOI: 10.2188/jea.JE20170255

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  • Yasuyuki Nakamura, Akira Narita, Tsuyoshi Hachiya, Yoichi Sutoh, Atsushi Shimizu, Seiko Ohno, Naoyuki Takashima, Keitaro Tanaka, Megumi Hara, Kiyoshi Kuriki, Kaori Endoh, Isao Oze, Hidemi Ito, Hirokazu Uemura, Sakurako Katsuura-Kamano, Haruo Mikami, Yohko Nakamura, Ippei Shimoshikiryo, Toshiro Takezaki, Sadao Suzuki, Miki Watanabe, Nagato Kuriyama, Teruhide Koyama, Norihiro Furusyo, Hiroaki Ikezaki, Masahiro Nakatochi, Sayo Kawai, Asahi Hishida, Rieko Okada, Takashi Tamura, Mariko Naito, Kenji Wakai, Yukihide Momozawa, Michiaki Kubo, Hirotsugu Ueshima, Yoshikuni Kita, for the J-MICC Research Group .  A Genome-wide Association Study in the Diabetic Patients Finds the 13q35.43-35.46 Locus Associated with Estimated Glomerular Filtration Rate: The Japan Multi-Institutional Collaborative Cohort study. .  J Clin Diabetes2 ( 2 ) 1000102   2018A Genome-wide Association Study in the Diabetic Patients Finds the 13q35.43-35.46 Locus Associated with Estimated Glomerular Filtration Rate: The Japan Multi-Institutional Collaborative Cohort study.Reviewed

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  • Tamura T, Kadomatsu Y, Tsukamoto M, Okada R, Sasakabe T, Kawai S, Hishida A, Hara M, Tanaka K, Shimoshikiryo I, Takezaki T, Watanabe I, Matsui D, Nishiyama T, Suzuki S, Endoh K, Kuriki K, Kita Y, Katsuura-Kamano S, Arisawa K, Ikezaki H, Furusyo N, Koyanagi YN, Oze I, Nakamura Y, Mikami H, Naito M, Wakai K .  Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study. .  Medicine (Baltimore)97   e13241   2018Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study.Reviewed

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  • Kanouchi H, Toyoda K, Miyazaki H, Mantjoro EM, Niimura H, Kuwabara K, Tsunematsu Nakahata N, Ibusuki R, Maenohara S, Takezaki T .  Relationship between Dietary Habits and Plasma Homocysteine Concentrations in Elderly Japanese Women and Men. .  Food and Nutrition Sciences9   595 - 608   2018Relationship between Dietary Habits and Plasma Homocysteine Concentrations in Elderly Japanese Women and Men.Reviewed

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  • Kairupan TS, Ibusuki R, Kheradmand M, Sagara Y, Mantjoro EM, Nindita Y, Niimura H, Kuwabara K, Ogawa S, Tsumematsu-Nakahata N, Nerome Y, Owaki T, Matsushita T, Maenohara S, Yamaguchi K, Takezaki T .  Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population. .  J Epidemiol27 ( 9 ) 420 - 427   2017.9Invited Reviewed

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    BACKGROUND: An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases. METHOD: We selected 2180 sub-cohort subjects aged 35-69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-alpha, IL-10, and NF-kappaB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases. RESULTS: HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-alpha 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-kappaB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18-7.77). CONCLUSION: The present study found the interaction between TNF-alpha 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.

    DOI: 10.1016/j.je.2016.08.017

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  • Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, Suzuki S, Kita Y, Takezaki T, Tanaka K, Morita M, Uemura H, Ozaki E, Hosono S, Mikami H, Kubo M, Tanaka H .  ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men. .  Nagoya J Med Sci78   183 - 193   2016.5ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men.Reviewed

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  • Nakahata NT, Takada AN, Imaeda N, Goto C, Kuwabara KH, Niimura H, Arai Y, Yoshita K, Takezaki T .  Validity of a food frequency questionnaire in a population with high alcohol consumption in Japan. .  Asia Pac J Clin Nutr25 ( 1 ) 195 - 201   2016.3Reviewed

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    BACKGROUND AND OBJECTIVES: Alcohol consumption has a relatively large impact on energy intake in drinkers, and several studies reported different dietary habits from non-drinkers. However, few studies have investigated the influence of alcohol consumption on the validity of the Food Frequency Questionnaire (FFQ). To investigate its influence, we conducted a validity test in a population with high alcohol consumption. METHODS AND STUDY DESIGN: The study subjects were 66 residents living on an island in the south-western part of Japan. We conducted the FFQ and 12-day-weighed dietary records (12d-WDRs) in each 3 day of each 4 season. We calculated Pearson correlation coefficients (CCs) and agreement rates according to quartile classification after adjusting for energy. RESULTS: The intake energy (kcal) estimated from 12d-WDRs and FFQ was 1,641 and 1,534 in women, and 2,093 and 1,979 in men, respectively. The cumulative percentage contribution of the alcohol energy was 6.7% in men. De-attenuated, log-transformed Pearson's median CCs between the nutrients quantified with the 12d-WDRs and FFQ were 0.51 in women and 0.38 in men. The CCs for carbohydrate and saturated fatty acids intake of men were lower than those in the previous Tokai study using the same FFQ. The findings in agreement rates were consistent with the Tokai study. CONCLUSION: This study suggested that the FFQ can be used for epidemiological studies using categorical comparisons in this population, although the underestimation of carbohydrates and other nutrients in the FFQ should be taken into consideration.

    DOI: 10.6133/apjcn.2016.25.1.10.

  • Mantjoro EM, Toyota K, Kanouchi H, Kheradmand M, Niimura H, Kuwabara K, Nakahata N, Ogawa S, Shimatani K, Kairupan TS, Nindita Y, Ibusuki R, Nerome Y, Owaki T, Maenohara S, Takezaki T .  Positive association of plasma homocysteine with cardio-ankle vascular index in a prospective study of Japanese men from the general population. .  J Atheroscler Thromb23   2016.1Positive association of plasma homocysteine with cardio-ankle vascular index in a prospective study of Japanese men from the general population.Reviewed

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    AIM: Observational studies have reported that elevated homocysteine (Hcy) levels are associated with the risk of cardiovascular disease (CVD). However, interventions that lower Hcy do not provide a corresponding risk reduction. Therefore, the causal role of Hcy in CVD remains unclear. This 5-year prospective study investigated the associations of Hcy levels, folate intake, and host factors with arterial stiffness among the general Japanese population. MEHODS: We prospectively recruited 658 participants (40-69 years old) from the general population during regular health checkup examinations. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) at baseline and the 5-year follow-up. Folate intake was estimated using a structured questionnaire. Genotyping was used to evaluate the MTHFR C677T and MS A2756G gene polymorphisms. Ultrafast liquid chromatography was used to measure total plasma Hcy levels. Association between these variables and CAVI values was evaluated using general linear regression and logistic regression models that were adjusted for atherosclerosis-related factors. RESULTS: Men had higher Hcy levels and CAVI values and lower folate intake than women (all, p<0.001). At baseline, Hcy, folate intake, and the two genotypes were not associated with CAVI values for both sexes. Among men, Hcy levels were positively associated with CAVI values at the 5-year follow-up (p=0.033). Folate intake and the two genotypes were not associated with the 5-year CAVI values. CONCLUSION: Plasma Hcy may be involved in arterial stiffness progression, as monitored using CAVI, among men.

  • Nerome Y, Kojyo K, Ninomiya Y, Ishikawa T, Ogiso A, Takei S, Kawano Y, Douchi T, Takezaki T, Owaki T .  Current human T-cell lymphotropic virus type 1 mother-to-child transmission prevention status in Kagoshima. .  Pediatr Int56 ( 4 ) 640 - 643   2014.8Current human T-cell lymphotropic virus type 1 mother-to-child transmission prevention status in Kagoshima.Reviewed

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  • Fukumoto K, Ito H, Matsuo K, Tanaka H, Yokoi K, Tajima K, Takezaki T .  Cigarette smoke inhalation and risk of lung cancer: a case-control study in a large Japanese population. .  Eur J Cancer Prev. 2014 Jun 6. [Epub ahead of print]   2014.6Cigarette smoke inhalation and risk of lung cancer: a case-control study in a large Japanese population.Reviewed

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  • Nakamura A, Niimura H, Kuwabara K, Takezaki T, Morita E, Wakai K, Hamajima N, Nishida Y, Turin TC, Suzuki S, Ohnaka K, Uemura H, Ozaki E, Hosono S, Mikami H, Kubo M, Tanaka H .  Gene-Gene Combination Effect and Interactions among ABCA1, APOA1, SR-B1, and CETP Polymorphisms for Serum High-Density Lipoprotein-Cholesterol in the Japanese Population .  PLOS ONE8 ( 12 ) e82046 - 2013   2013.12Gene-Gene Combination Effect and Interactions among ABCA1, APOA1, SR-B1, and CETP Polymorphisms for Serum High-Density Lipoprotein-Cholesterol in the Japanese PopulationReviewed

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  • Kheradmand M, Niimura H, Kuwabara K, Nakahata N, Nakamura A, Ogawa S, Mantjoro EM, Shimatani K, Nerome Y, Owaki T, Kusano K, Takezaki T .  Association of Inflammatory Gene Polymorphisms and Conventional Risk Factors With Arterial Stiffness by Age .  J Epidemiol23 ( 6 ) 457 - 465   2013.9Association of Inflammatory Gene Polymorphisms and Conventional Risk Factors With Arterial Stiffness by AgeReviewed

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  • Hishida A, Morita E, Naito M, Okada R, Wakai K, Matsuo K, Nakamura K, Takashima N, Suzuki S, Takezaki T, Mikami H, Ohnaka K, Watanabe Y, Uemura H, Kubo M, Tanaka H, Hamajima N .  Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study. .  Endocr J59 ( 7 ) 589 - 599   2012.5Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.Reviewed

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  • Okada R, Wakai K, Naito M, Morita E, Kawai S, Hamajima N, Hara M, Takashima N, Suzuki S, Takezaki T, Ohnaka K, Arisawa K, Hirohata H, Matsuo K, Mikami H, Kubo M, Tanaka H .  Pro/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study. .  BMC Nephrol13   2   2012.1Pro/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study.Reviewed

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  • Hirasada K, Niimura H, Kubozono T, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N, Chiba S, Matsushita T, Kusano K, Miyata M, Takezaki T .  Values of cardio-ankle vascular index (CAVI) between Amami islands and Kagoshima mainland among health checkup examinees. .  J Atheroscler Thromb19 ( 1 ) 69 - 80   2012.1Values of cardio-ankle vascular index (CAVI) between Amami islands and Kagoshima mainland among health checkup examinees.Reviewed

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  • Wakai K, Hamajima N, Okada R, Naito M, Morita E, Hishida A, Kawai S, Nishio K, Yin G, Asai Y, Matsuo K, Hosono S, Ito H, Watanabe M, Kawase T, Suzuki T, Tajima K, Tanaka K, Higaki Y, Hara M, Imaizumi T, Taguchi N, Nakamura K, Nanri H, Sakamoto T, Horita M, Shinchi K, Kita Y, Turin TC, Rumana N, Matsui K, Miura K, Ueshima H, Takashima N, Nakamura Y, Suzuki S, Ando R, Hosono A, Imaeda N, Shibata K, Goto C, Hattori N, Fukatsu M, Yamada T, Tokudome S, Takezaki T, Niimura H, Hirasada K, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N, Chiba S, Mikami H, Kono S, Ohnaka K, Takayanagi R, Watanabe Y, Ozaki E, Shigeta M, Kuriyama N, Yoshikawa A, Matsui D, Watanabe I, Inoue K, Ozasa K, Mitani S, Arisawa K, Uemura H, Hiyoshi M, Takami H, Yamaguchi M, Nakamoto M, Takeda H, Kubo M, Tanaka H .  Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. .  J Epidemiol21 ( 3 ) 223 - 235   2011.3Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.Reviewed

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  • Katanoda K, Sobue T, Satoh H, Tajima K, Suzuki T, Nakatsuka H, Takezaki T, Nakayama T, Nitta H, Tanabe K, Tominaga S .  An association between long-term exposure to ambient air pollution and mortality from lung cancer and respiratory diseases in Japan. .  J Epidemiol21 ( 2 ) 132 - 143   2011.2An association between long-term exposure to ambient air pollution and mortality from lung cancer and respiratory diseases in Japan.Reviewed

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  • Park JY, Matsuo K, Suzuki T, Ito H, Hosono S, Kawase T, Watanabe M, Oze I, Hida T, Yatabe Y, Mitsudomi T, Takezaki T, Tajima K, Tanaka H .  Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 (ALDH2) null allele in a Japanese population. .  Carcinogenesis31 ( 4 ) 660 - 665   2010.4Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 (ALDH2) null allele in a Japanese population.Reviewed

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  • Gao CM, Gong JP, Wu JZ, Cao HX, Ding JH, Zhou JN, Liu YT, Li SP, Cao J, Matsuo K, Takezaki T, Tajima K .  Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer. .  J Hum Genet55 ( 3 ) 163 - 166   2010.3Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer.Reviewed

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  • Gao CM, Tajima K, Ding JH, Tang JH, Wu JZ, Li SP, Cao HX, Liu YT, Su P, Qian Y, Chang J, Takezaki T .  Body size, physical activity and risk of breast cancer - a case control study in jangsu province of china. .  Asian Pac J Cancer Prev10 ( 5 ) 877 - 881   2009.10Body size, physical activity and risk of breast cancer - a case control study in jangsu province of china.Reviewed

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  • Langevin SM, Lin D, Matsuo K, Gao CM, Takezaki T, Stolzenberg Solomon RZ, Vasavi M, Hasan Q, Taioli E .  Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer. .  Toxicol Lett184 ( 2 ) 73 - 80   2009.9Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer.Reviewed

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  • Gao CM , Tang JH , Cao HX , Ding JH , Wu JZ , Wang J , Liu YT , Li SP , Su P , Matsuo K , Takezaki T , Tajima K .  MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women. .  J Hum Genet 54 ( 7 ) 414 - 418   2009.6MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women.Reviewed

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  • 秋葉澄伯、嶽崎俊郎 .  離島へき地医療人育成国際シンポジウムの開催. .  鹿児島大学医学部医学科同窓会鶴陵会會報37   29 - 31   2008.12離島へき地医療人育成国際シンポジウムの開催.

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  • 嶽崎俊郎 .  離島へき地医療人育成の取. .  厚生労働63 ( 10 ) 46 - 46   2008.10離島へき地医療人育成の取.

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  • Gao CM, Takezaki T, Wu JZ, Zhang XM, Cao HX, Ding JH, Liu YT, Li S , Cao J, Matsuo K, Hamajima N, Tajima K .  Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males. .  World J Gastroenterol 14 ( 32 ) 5078 - 5083   2008.9Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males.Reviewed

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  • Cao HX, Gao CM, Takezaki T, Wu JZ, Ding JH, Liu YT, Li SP, Su P, Cao J, Hamajima N , Tajima K .  Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer. .  Asian Pac J Cancer Prev9 ( 2 ) 203 - 208   2008.4Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer.Reviewed

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  • Boccia S , Hung R , Ricciardi G , Gianfagna F , Ebert MP , Fang JY , Gao CM , Gotze T , Graziano F , Lacasana Navarro M , Lin D , Lopez Carrillo L , Qiao YL , Shen H , Stolzenberg Solomon R , Takezaki T , Weng YR , Zhang FF , van Duijn CM , Boffetta P , Taioli E .  Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. .  Am J Epidemiol167 ( 5 ) 505 - 516   2008.3Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.Reviewed

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  • Gao CM , Takezaki T , Wu JZ , Chen MB , Liu YT , Ding JH , Sugimura H , Cao J , Hamajima N , Tajima K .  CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking. .  World J Gastroenterol13 ( 43 ) 5725 - 5730   2007.11CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.Reviewed

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  • Kozako T, Arima N, Toji S, Masamoto I, Akimoto M, Hamada H, Che XF, Fujiwara H, Matsushita K, Tokunaga M, Haraguchi K, Uozumi K, Suzuki S, Takezaki T, Sonoda S .  Reduced Frequency, Diversity, and Function of Human T Cell Leukemia Virus Type 1-Specific CD8+ T Cell in Adult T Cell Leukemia Patients. .  J Immunol177 ( 8 ) 5718 - 5726   2006.10Reduced Frequency, Diversity, and Function of Human T Cell Leukemia Virus Type 1-Specific CD8+ T Cell in Adult T Cell Leukemia Patients.Reviewed

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  • Kuriki K, Hirose K, Matsuo K, Wakai K, Ito H, Kanemitsu Y, Hirai T, Kato T, Hamajima N, Takezaki T, Suzuki T, Saito T, Tanaka R, Tajima K .  Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. .  Cancer Sci97 ( 11 ) 1226 - 1235   2006Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese.Reviewed

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  • Li K, Takezaki T, Song FY, Yu P, Lin XK, Yang HL, Deng XL, Zhang YQ, Lv LW, Huang XE, Tajima K .  The KOJACH food frequency questionnaire for Chaoshan, China: development and description. .  Asia Pac J Clin Nutr15 ( 2 ) 153 - 160   2006The KOJACH food frequency questionnaire for Chaoshan, China: development and description.Reviewed

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  • Marugame T, Sobue T, Satoh H, Komatsu S, Nishino Y, Nakatsuka H, Nakayama T, Suzuki T, Takezaki T, Tajima K, Tominaga S .  Lung cancer death rates by smoking status: Comparison of the Three-Prefecture Cohort study in Japan to the Cancer Prevention Study II in the USA. .  Cancer Sci96 ( 2 ) 120 - 126   2005Lung cancer death rates by smoking status: Comparison of the Three-Prefecture Cohort study in Japan to the Cancer Prevention Study II in the USA.Reviewed

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  • Li K, Takezaki T, Lv LW, Yu P, Song FY, Tajima K .  Reproducibility of a semi-quantitative food frequency questionnaire in Chaoshan area, China. .  Asian Pac J Cancer Prev6 ( 4 ) 521 - 526   2005Reproducibility of a semi-quantitative food frequency questionnaire in Chaoshan area, China.Reviewed

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  • Ke L, Toshiro T, Fengyan S, Ping Y, Xiaoling D, Kazuo T .  Relative validity of a semi-quantitative food frequency questionnaire versus 3 day weighed diet records in middle-aged inhabitants in Chaoshan area, China. .  Asian Pac J Cancer Prev6 ( 3 ) 376 - 381   2005Relative validity of a semi-quantitative food frequency questionnaire versus 3 day weighed diet records in middle-aged inhabitants in Chaoshan area, China.Reviewed

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  • Song FY, Toshiro T, Li K, Yu P, Lin XK, Yang HL, Deng XL, Zhang YQ, Lv LW, Huang XE, Kazuo T .  Development of a semi-quantitative food frequency questionnaire for middle-aged inhabitants in the Chaoshan area, China. .  World J Gastroenterol11 ( 26 ) 4078 - 4084   2005Development of a semi-quantitative food frequency questionnaire for middle-aged inhabitants in the Chaoshan area, China.Reviewed

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  • Muscat JE, Takezaki T, Tajima K, Stellman SD .  Charcoal cigarette filters and lung cancer risk in Aichi Prefecture, Japan. .  Cancer Sci96 ( 5 ) 283 - 287   2005Charcoal cigarette filters and lung cancer risk in Aichi Prefecture, Japan.Reviewed

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  • Sonoda J, Koriyama C, Yamamoto S, Kozako T, Li HC, Lema C, Yashiki S, Fujiyoshi T, Yoshinaga M, Nagata Y, Akiba S, Takezaki T, Yamada K, Sonoda S .  HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking. .  Cancer Sci95 ( 7 ) 596 - 601   2004HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking.Reviewed

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  • Zhou ZY, Takezaki T, Mo BQ, Sun HM, Wang WC, Sun LP, Liu SX, Ao L, Cheng GH, Wang YM, Cao J, Tajima K .  Development of a semi-quantitative food frequency questionnaire to determine variation in nutrient intakes between urban and rural areas of Chongqing, China. .  Asia Pac J Clin Nutr13 ( 3 ) 273 - 283   2004Development of a semi-quantitative food frequency questionnaire to determine variation in nutrient intakes between urban and rural areas of Chongqing, China.Reviewed

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  • Wakai K, Hirose K, Takezaki T, Hamajima N, Ogura Y, Nakamura S, Hayashi N, Tajima K .  Foods and beverages in relation to urothelial cancer: Case-control study in Japan. .  Int J Urol11 ( 1 ) 11 - 19   2004Foods and beverages in relation to urothelial cancer: Case-control study in Japan.Reviewed

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  • Shinmura K, Tao H, Goto M, Igarashi H, Taniguchi T, Maekawa M, Takezaki T, Sugimura H .  Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer. .  Carcinogenesis25 ( 12 ) 2311 - 2317   2004Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.Reviewed

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  • Huang XE, Hirose K, Wakai K, Matsuo K, Ito H, Xiang J, Takezaki T, Tajima K .  Comparison of lifestyle risk factors by family history for gastric, breast, lung and colorectal cancer. .  Asian Pac J Cancer Prev5 ( 4 ) 419 - 427   2004Comparison of lifestyle risk factors by family history for gastric, breast, lung and colorectal cancer.Reviewed

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  • Gao CM, Takezaki T, Wu JZ, Liu YT, Ding JH, Li SP, Su P, Hu X, Kai HT, Li ZY, Matsuo K, Hamajima N, Sugimura H, Tajima K .  Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking. .  Asian Pac J Cancer Prev5 ( 2 ) 133 - 138   2004Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking.Reviewed

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  • Gao CM, Takezaki T, Wu JZ, Ding JH, Liu YT, Li SP, Su P, Hu X, Xu TL, Hamajima N, Tajima K .  Methylenetetrahydrofolate reductase genotypes, dietary habits and susceptibility to stomach cancer .  Chinese J Clin Oncol1 ( 3 ) 162 - 166   2004Methylenetetrahydrofolate reductase genotypes, dietary habits and susceptibility to stomach cancerReviewed

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  • Chiba H, Tretli S, Lund E, Wakai K, Takezaki T, Senoo H, Sonoda S, Tajima K .  Lack of HTLV-I Carriers in the Sami, an Ethnic Group Living in the Arctic Area in Norway. .  Asian Pac J Cancer Prev5 ( 1 ) 50 - 53   2004Lack of HTLV-I Carriers in the Sami, an Ethnic Group Living in the Arctic Area in Norway.Reviewed

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  • Chiba H, Takezaki T, Neupani D, Kim J, Yoshida S, Mizoguchi E, Takeuchi J, Suzuki J, Tanaka Y, Ito K, Kitamura T, Kuriki K, Wakai K, Samejima K, Sonoda S, Tajima K .  An Epidemiological Study of HBV, HCV and HTLV-I in Sherpas of Nepal. .  Asian Pac J Cancer Prev5 ( 4 ) 370 - 373   2004An Epidemiological Study of HBV, HCV and HTLV-I in Sherpas of Nepal.Reviewed

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  • Hirose K, Hamajima N, Takezaki T, Miura S, Tajima K .  Physical exercise reduces risk of breast cancer in Japanese women. .  Cancer Sci94 ( 2 ) 193 - 199   2003Physical exercise reduces risk of breast cancer in Japanese women.Reviewed

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  • Yang CX, Takezaki T, Hirose K, Inoue M, Huang XE, Tajima K .  Fish consumption and colorectal cancer: a case-reference study in Japan. .  Eur J Cancer Prev12 ( 2 ) 109 - 115   2003Fish consumption and colorectal cancer: a case-reference study in Japan.Reviewed

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  • Wang YM, Mo BQ, Takezaki T, Imaeda N, Kimura M, Wang XR, Tajima K .  Geographical Variation in Nutrient Intake between Urban and Rural Areas of Jiangsu Province, China and Development of a Semi-Quantitative Food Frequency Questionnaire for Middle-Aged Inhabitants. .  J Epidemiol13 ( 2 ) 80 - 89   2003Geographical Variation in Nutrient Intake between Urban and Rural Areas of Jiangsu Province, China and Development of a Semi-Quantitative Food Frequency Questionnaire for Middle-Aged Inhabitants.Reviewed

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  • Tamakoshi A, Hamajima N, Kawase H, Wakai K, Katsuda N, Saito T, Ito H, Hirose K, Takezaki T, Tajima K .  Duplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for genotyping alcohol dehydrogenase beta subunit (ADH2) and aldehyde dehydrogenase 2 (ALDH2). .  Alcohol Alcohol38 ( 5 ) 407 - 410   2003Duplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for genotyping alcohol dehydrogenase beta subunit (ADH2) and aldehyde dehydrogenase 2 (ALDH2).Reviewed

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  • Takezaki T, Inoue M, Kataoka H, Ikeda S, Yoshida M, Ohashi Y, Tajima K, Tominaga S .  Diet and lung cancer risk from a 14-year population-based prospective study in Japan: with special reference to fish consumption. .  Nutr Cancer45 ( 2 ) 160 - 167   2003Diet and lung cancer risk from a 14-year population-based prospective study in Japan: with special reference to fish consumption.Reviewed

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  • Ito LS, Inoue M, Tajima K, Yamamura Y, Kodera Y, Hirose K, Takezaki T, Hamajima N, Kuroishi T, Tominaga S .  Dietary factors and the risk of gastric cancer among Japanese women: a comparison between the differentiated and non-differentiated subtypes. .  Ann Epidemiol13 ( 1 ) 24 - 31   2003Dietary factors and the risk of gastric cancer among Japanese women: a comparison between the differentiated and non-differentiated subtypes.Reviewed

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  • Inoue M, Tajima K, Takezaki T, Hamajima N, Hirose K, Ito H, Tominaga S .  Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC). .  Int J Epidemiol32 ( 2 ) 257 - 262   2003Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC).Reviewed

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  • Hirose K, Toyama T, Iwata H, Takezaki T, Hamajima N, Tajima K .  Insulin, Insulin-like Growth Factor-I and Breast Cancer Risk in Japanese Women. .  Asian Pac J Cancer Prev4 ( 3 ) 239 - 246   2003Insulin, Insulin-like Growth Factor-I and Breast Cancer Risk in Japanese Women.Reviewed

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  • Hirose K, Takezaki T, Hamajima N, Miura S, Tajima K .  Dietary factors protective against breast cancer in Japanese premenopausal and postmenopausal women. .  Int J Cancer107 ( 2 ) 276 - 282   2003Dietary factors protective against breast cancer in Japanese premenopausal and postmenopausal women.Reviewed

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  • Hirose K, Tajima K, Hamajima N, Takezaki T, Inoue M, Kuroishi T, Miura S .  Impact of established risk factors for breast cancer in nulligravid Japanese women. .  Breast Cancer10 ( 1 ) 45 - 53   2003Impact of established risk factors for breast cancer in nulligravid Japanese women.Reviewed

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  • Gao C, Takezaki T, Wu J, Li Z, Wang J, Ding J, Liu Y, Hu X, Xu T, Tajima K, Sugimura H .  Interaction between cytochrome P450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese. .  Cancer Epidemiol Biomarkers Prev11 ( 1 ) 29 - 34   2002Interaction between cytochrome P450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese.Reviewed

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  • Yang CX, Hamajima N, Iwata H, Saito T, Matsuo K, Hirose K, Inoue M, Takezaki T, Tajima K .  A49T, V89L, TA repeat polymorphisms of steroid 5α-reductase type II (SRD5A2) and breast cancer risk in Japanese. .  Breast Cancer Res4 ( 4 ) R8 - ※   2002A49T, V89L, TA repeat polymorphisms of steroid 5α-reductase type II (SRD5A2) and breast cancer risk in Japanese.Reviewed

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  • Uno M, Hamajima N, Ito LS, Oba SM, Marie SK, Shinjo SK, Onda H, Saito T, Takezaki T, Tajima K, Tominaga S .  Helicobacter pylori seropositivity and IL-1B C-31T polymorphism among Japanese Brazilians. .  Int J Mol Med10 ( 3 ) 321 - 326   2002Helicobacter pylori seropositivity and IL-1B C-31T polymorphism among Japanese Brazilians.Reviewed

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  • Takezaki T, Gao CM, Wu JZ, Li ZY, Wang JD, Ding JH, Liu YT, Hu X, Xu TL, Tajima K, Sugimura H .  The hOGG1 ser326cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese. .  Int J Cancer99 ( 4 ) 624 - 627   2002The hOGG1 ser326cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese.Reviewed

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  • Matsuo K, Hamajima N, Hirai T, Kato T, Koike K, Inoue M, Takezaki T, Tajima K .  Aldehyde dehydrogenase 2 (ALDH2) genotype affects rectal cancer susceptibility due to alcohol consumption. .  J Epidemiol12 ( 2 ) 70 - 76   2002Aldehyde dehydrogenase 2 (ALDH2) genotype affects rectal cancer susceptibility due to alcohol consumption.Reviewed

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  • Matsuo K, Hamajima N, Hirai T, Kato T, Inoue M, Takezaki T, Tajima K .  Methionine synthase reductase polymorphism and susceptibility to colorectal cancer. .  Asian Pac J Cancer Prev3 ( 4 ) 353 - 359   2002Methionine synthase reductase polymorphism and susceptibility to colorectal cancer.Reviewed

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  • Ito H, Hamajima N, Takezaki T, Matsuo K, Tajima K, Hatooka S, Mitsudomi T, Suyama M, Sato S, Ueda R .  A limited association of OGG1 Ser326Cys polymorphism for adenocarcinoma of the lung. .  J Epidemiol12 ( 3 ) 258 - 65   2002A limited association of OGG1 Ser326Cys polymorphism for adenocarcinoma of the lung.Reviewed

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  • Inoue M, Ito LS, Tajima K, Yamamura Y, Kodera Y, Takezaki T, Hamajima N, Hirose K, Kuroishi T, Tominaga S .  Height, weight, menstrual and reproductive factors and risk of gastric cancer among Japanese postmenopausal women: Analysis by subsite and histologic subtype. .  Int J Cancer97 ( 6 ) 833 - 838   2002Height, weight, menstrual and reproductive factors and risk of gastric cancer among Japanese postmenopausal women: Analysis by subsite and histologic subtype.Reviewed

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  • Gao CM, Takezaki T, Wu JZ, Li ZY, Liu YT, Li SP, Ding JH, Su P, Hu X, Xu TL, Sugimura H, Tajima K .  GSTM1 and GSTT1 Genotype, Consumption of Alcohol and Tea and Risk of Esophageal and Stomach Cancers: A Case-Control Study of a High-incidence Area in Jiangsu Province, China. .  Cancer Lett188 ( 2007/1/2 ) 95 - 102   2002GSTM1 and GSTT1 Genotype, Consumption of Alcohol and Tea and Risk of Esophageal and Stomach Cancers: A Case-Control Study of a High-incidence Area in Jiangsu Province, China.Reviewed

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  • Hamajima N, Katsuda N, Matsuo K, Saito T, Ito LS, Ando M, Inoue M, Takezaki T, Tajima K .  Smoking habit and interleukin lB C-31T polymorphism. .  J Epidemiol11 ( 3 ) 120 - 125   2001Smoking habit and interleukin lB C-31T polymorphism.Reviewed

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  • Zhao SM, Li HC, Lou H, Lu XX, Yu XF, Gao DH, Hu J, Chiba H, Takezaki T, Takeshita H, Yashiki S, Fujiyoshi T, Sonoda S, Tajima K .  High prevalence of HBV in Tibet, China. .  Asian Pacific J Cancer Prev2 ( 4 ) 299 - 304   2001High prevalence of HBV in Tibet, China.Reviewed

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  • Takezaki T, Hirose K, Inoue M, Hamajima N, Yatabe Y, Mitsudomi T, Sugiura T, Kuroishi T, Tajima K .  Dietary factors and lung cancer risk in Japanese: with special reference to fish consumption and adenocarcinomas. .  Br J Cancer84 ( 9 ) 1199 - 1206   2001Dietary factors and lung cancer risk in Japanese: with special reference to fish consumption and adenocarcinomas.Reviewed

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  • Takezaki T, Hamajima N, Matsuo K, Tanaka R, Hirai T, Kato T, Ohashi K, Tajima K .  Association of polymorphisms in the beta-2 and beta-3 adrenoceptor genes with risk of colorectal cancer in Japanese. .  Int J Clin Oncol6 ( 3 ) 117 - 122   2001Association of polymorphisms in the beta-2 and beta-3 adrenoceptor genes with risk of colorectal cancer in Japanese.Reviewed

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  • Takezaki T, Gao CM, Wu JZ, Ding JH, Liu YT, Zhang Y, Li SP, Su P, Liu TK, Tajima K .  Dietary protective and risk factors for esophageal and stomach cancers in a low-epidemic area for stomach cancer in Jiangsu Province, China; comparison with those in a high-epidemic area. .  Jpn J Cancer Res92 ( 11 ) 1157 - 1165   2001Dietary protective and risk factors for esophageal and stomach cancers in a low-epidemic area for stomach cancer in Jiangsu Province, China; comparison with those in a high-epidemic area.Reviewed

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  • Stellman SD, Takezaki T, Wang L, Chen Y, Citron ML, Djordjevic MV, Harlap S, Muscat JE, Neugut AI, Wynder AL, Ogawa H, Tajima K, Aoki K .  Smoking and lung cancer risk in American and Japanese men: an international case-control study. .  Cancer Epidemiol Biomarkers Prev10 ( 11 ) 1193 - 1199   2001Smoking and lung cancer risk in American and Japanese men: an international case-control study.Reviewed

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  • Matsuo K, Hamajima N, Shinoda M, Hatooka S, Inoue M, Takezaki T, Tajima K .  Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. .  Carcinogenesis22 ( 6 ) 913 - 916   2001Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer.Reviewed

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  • Matsuo K, Hamajima N, Shinoda M, Hatooka S, Inoue M, Takezaki T, Onda H, Tajima K .  Possible risk reduction in esophageal cancer associated with MPO -463 A allele. .  J Epidemiol11 ( 3 ) 109 - 114   2001Possible risk reduction in esophageal cancer associated with MPO -463 A allele.Reviewed

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  • Matsuo K, Hamajima N, Hirose K, Inoue M, Takezaki T, Kuroishi T, Tajima K .  Alcohol, Smoking, and Dietary Status and Susceptibility to Malignant Lymphoma in Japan: Results of a Hospital-based Case-control Study at Aichi Cancer Center. .  Jpn J Cancer Res92 ( 10 ) 1011 - 1017   2001Alcohol, Smoking, and Dietary Status and Susceptibility to Malignant Lymphoma in Japan: Results of a Hospital-based Case-control Study at Aichi Cancer Center.Reviewed

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  • Ito H, Matsuo K, Hirose K, Inoue M, Takezaki T, Hamajima N, Kuroishi T, Tajima K .  Valid responses to ABO blood type question in self-reporting questionnaire. .  Asian Pacific J Cancer Prev2 ( 4 ) 315 - 317   2001Valid responses to ABO blood type question in self-reporting questionnaire.Reviewed

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  • Hirose K, Tajima K, Hamajima N, Takezaki T, Inoue M, Kuroishi T, Miura S, Tokudome S .  Association of family history and other risk factors with breast cancer risk among Japanese premenopausal and postmenopausal women. .  Cancer Causes Control12 ( 4 ) 349 - 358   2001Association of family history and other risk factors with breast cancer risk among Japanese premenopausal and postmenopausal women.Reviewed

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  • Hamajima N, Takezaki T, Matsuo K, Saito T, Inoue M, Hirai T, Kato T, Ozeki J, Tajima K .  Genotype frequencies of cyclooxygenase 2 (COX2) rare polymorphisms for Japanese with and without colorectal cancer. .  Asian Pacific J Cancer Prev2 ( 1 ) 57 - 62   2001Genotype frequencies of cyclooxygenase 2 (COX2) rare polymorphisms for Japanese with and without colorectal cancer.Reviewed

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  • Huang XE, Tajima K, Hamajima N, Xiang J, Inoue M, Hirose K, Tominaga S, Takezaki T, Kuroishi T, Tokudome S .  Comparison of lifestyle and risk factors among Japanese with and without gastric cancer family history. .  Int J Cancer86 ( 3 ) 421 - 424   2000Comparison of lifestyle and risk factors among Japanese with and without gastric cancer family history.Reviewed

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  • Takezaki T, Shinoda M, Hatooka S, Hasegawa Y, Nakamura S, Hirose K, Inoue M, Hamajima N, Kuroishi T, Matsuura H, Tajima K .  Subsite-specific risk factors for hypopharyngeal and esophageal cancer (Japan). .  Cancer Causes Control11 ( 7 ) 597 - 608   2000Subsite-specific risk factors for hypopharyngeal and esophageal cancer (Japan).Reviewed

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  • Gao C, Takezaki T, Ding J, Li M, Tajima K .  Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China. .  Jpn J Cancer Res90 ( 6 ) 614 - 621   1999Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China.Reviewed

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  • Yoo KY, Tajima K, Inoue M, Takezaki T, Hirose K, Hamajima N, Park SK, Kang DH, Kato T, Hirai T .  Reproductive factors related to the risk of colorectal cancer by subsite: a case-control analysis. .  Br J Cancer79 ( 2007/11/12 ) 1901 - 1906   1999Reproductive factors related to the risk of colorectal cancer by subsite: a case-control analysis.Reviewed

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  • Takezaki T, Gao C, Ding J, Liu T, Li M, Tajima K .  Comparative study of lifestyles of residents in high and low risk areas for gastric cancer in Jiangsu Province, China; with special reference to allium vegetables. .  J Epidemiol9 ( 5 ) 297 - 305   1999Comparative study of lifestyles of residents in high and low risk areas for gastric cancer in Jiangsu Province, China; with special reference to allium vegetables.Reviewed

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  • Sugimura H, Kohno T, Wakai K, Nagura K, Genka K, Igarashi H, Morris BJ, Nagayama K, Baba S, Ohno Y, Gao C, Li Z, Wang J, Takezaki T, Tajima K, Varga T, Sawagichi T, Lum JK, Martinson JJ, Tsugane S, Iwamasa T, Shinmura K, Yokota J .  hOGG1 Ser326Cys polymorphinism and lung cancer susceptibility. .  Cancer Epidemiol Biomarkers Prev8 ( 8 ) 669 - 674   1999hOGG1 Ser326Cys polymorphinism and lung cancer susceptibility.Reviewed

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  • Huang XY, Tajima K, Hamajima N, Inoue M, Takezaki T, Kuroishi T, Hirose K, Tominaga S, Xiang J, Tokudome S .  Effect of life styles on the risk of subsite-specific gastric cancer in those with and without family history. .  J Epidemiol9 ( 1 ) 40 - 45   1999Effect of life styles on the risk of subsite-specific gastric cancer in those with and without family history.Reviewed

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  • Hirose K, Tajima K, Hamajima N, Takezaki T, Inoue M, Kuroishi T, Miura S, Tokudome S .  Effect of body size on breast-cancer risk among Japanese women. .  Int J Cancer80 ( 3 ) 349 - 355   1999Effect of body size on breast-cancer risk among Japanese women.Reviewed

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  • Hirose K, Hamajima N, Takezaki T, Kuroishi T, Kuzuya T, Sasaki S, Tokudome S, Tajima K .  Smoking and dietary factors for cervical cancer at different age group in Japan. .  J Epidemiol8 ( 1 ) 6 - 14   1998Smoking and dietary factors for cervical cancer at different age group in Japan.Reviewed

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  • Takezaki T, Setoyama M, Takezaki T, Takei S, Yashiki S, Sueyoshi K, Fukunaga H .  Spontaneous proliferative response of peripheral blood monocular cells in vitro as an indicator of high response to human T-lymphotropic virus type-I infection in an infant with interstitial pneumonia. .  Pediatr Infect Dis J17 ( 2 ) 166 - 168   1998Spontaneous proliferative response of peripheral blood monocular cells in vitro as an indicator of high response to human T-lymphotropic virus type-I infection in an infant with interstitial pneumonia.Reviewed

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  • Sugimura H, Wakai K, Genka K, Nagura K, Igarashi H, Nagayama K, Ohkawa A, Baba S, Morris BJ, Tsugane S, Ohno Y, Gao C, Li Z, Takezaki T, Tajima K, Iwamasa T .  Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa. .  Cancer Epidemiol Biomarkers Prev7 ( 5 ) 413 - 417   1998Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa.Reviewed

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  • Inoue M, Tajima K, Hirose K, Hamajima N, Takezaki T, Kuroishi T, Tominaga S .  Tea and coffee consumption and the risk of digestive tract cancers: data from a comparative case-referent study in Japan. .  Cancer Causes Control9 ( 2 ) 209 - 216   1998Tea and coffee consumption and the risk of digestive tract cancers: data from a comparative case-referent study in Japan.Reviewed

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  • Inoue M, Tajima K, Hirose K, Hamajima N, Takezaki T, Kuroishi T, Tominaga S .  Epidemiological features of first-visit outpatients in Japan: comparison with general population and variation by sex age and Season. .  J Clin Epidemol50 ( 1 ) 69 - 77   1997Epidemiological features of first-visit outpatients in Japan: comparison with general population and variation by sex age and Season.Reviewed

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  • Takezaki T, Tajima K, Ito M, Ito S, Kinoshita K, Tachibana T, Yamashita Y, The Tsushima ATL Study Group .  Short-term breast-feeding may reduce the risk of vertical transmission of HTLV-I. .  Leukemia 11(Supp11 ( Supp 3 ) 60 - 62   1997Short-term breast-feeding may reduce the risk of vertical transmission of HTLV-I.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Takezaki T, Hirose K, Hamajima N, Kuroishi T, Tajima K .  Estimation of Adult T-cell Leukemia (ATL) incidence in Kyushu district from Vital Statistics Japan between 1983 and 1992; comparison with a Nationwide Survey. .  Jpn J Clin Oncol27 ( 3 ) 140 - 145   1997Estimation of Adult T-cell Leukemia (ATL) incidence in Kyushu district from Vital Statistics Japan between 1983 and 1992; comparison with a Nationwide Survey.Reviewed

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  • Hirose K, Tajima K, Hamajima N, Takezaki T, Inoue M, Kuroishi T, Kuzuya T, Nakamura S, Tokudome S .  Subsite(cervix/endometrium)-specific risk and protective factors in uterus cancer. .  Jpn J Cancer Res87 ( 9 ) 1001 - 1009   1996Subsite(cervix/endometrium)-specific risk and protective factors in uterus cancer.Reviewed

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  • Takezaki T, Hirose K, Inoue M, Hamajima N, Kuroishi T, Nakamura S, Matsuura H, Tajima K .  Risk factors of thyroid cancer among women in Tokai Japan. .  J Epidemiol6 ( 3 ) 140 - 147   1996Risk factors of thyroid cancer among women in Tokai Japan.Reviewed

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  • Takezaki T, Hirose K, Inoue M, Hamajima N, Kuroishi T, Nakamura S, Koshikawa T, Matsuura H, Tajima K .  Tobacco, alcohol and dietary factors associated with the risk of oral cancer among Japanese. .  Jpn J Cancer Res87 ( 6 ) 555 - 562   1996Tobacco, alcohol and dietary factors associated with the risk of oral cancer among Japanese.Reviewed

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  • Hamajima N, Hirose K, Inoue M, Takezaki T, Kuroishi T, Tajima K .  Age specific risk factors of breast cancer estimated by a case-control study in Japan. .  J Epidemiol5 ( 2 ) 99 - 105   1995Age specific risk factors of breast cancer estimated by a case-control study in Japan.Reviewed

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  • Inoue M, Tajima K, Hirose K, Hamajima N, Takezaki T, Hirai T, Kato T, Ohno Y .  Subsite-specific risk factors for colorectal cancer: a hospital-based case-control study in Japan. .  Cancer Causes Control6 ( 1 ) 14 - 22   1995Subsite-specific risk factors for colorectal cancer: a hospital-based case-control study in Japan.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Hirose K, Tajima K, Hamajima N, Inoue M, Takezaki T, Kuroishi T, Yoshida M, Tokudome S .  A large-scale hospital-based case-control study of risk factors of breast cancer according to menopausal status. .  Jpn J Cancer Res86 ( 2 ) 146 - 154   1995A large-scale hospital-based case-control study of risk factors of breast cancer according to menopausal status.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Chiba Y, Xu A, Li L, Lei J, Takezaki T, Hagiwara A, Yoneyama T, Fujiwara T, Hara M, Yamamoto T .  Poliomyelitis surveillance in Shandong Province China 1990-92. .  Bull World Health Organ72 ( 6 ) 915 - 920   1994Poliomyelitis surveillance in Shandong Province China 1990-92.Reviewed

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  • Takezaki T, Tajima K, Komoda H, Imai J .  Incidence of human T lymphotropic virus type I seroconversion after age 40 among Japanese residents in an area where the virus is endemic. .  J Infect Dis171 ( 3 ) 559 - 565   1994Incidence of human T lymphotropic virus type I seroconversion after age 40 among Japanese residents in an area where the virus is endemic.Reviewed

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  • Hamajima N, Hirose K, Inoue M, Takezaki T, Kuroishi T, Tajima K .  Case-control studies: matched controls or all available controls? .  J Clin Epidemiol47 ( 9 ) 971 - 975   1994Case-control studies: matched controls or all available controls?Reviewed

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  • Chiba Y, Xu A, Li L, Liu G, Takezaki T, Urabe D, Yamamoto T, Minami R, Hagiwara A, Yoneyama T, Fijiwara T, Hara M .  Outbreaks of paralytic poliomyelitis and polio surveillance in Shandong province of China. .  Jpn J Med Sci Biol45 ( 2007/5/6 ) 255 - 266   1992Outbreaks of paralytic poliomyelitis and polio surveillance in Shandong province of China.Reviewed

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  • Takahashi K, Takezaki T, Oki T, Kawakami K, Yashiki S, Fujiyoshi T, Usuku K, Mueller N, The Mother-to-child Transmission Study Group, Osame M, Miyata K, Nagata Y, Sonoda S .  Inhibitory effect of maternal antibody on mother-to-child transmission of human T-lymphotropic virus type I. .  Int J Cancer49 ( 5 ) 1 - 5   1991Inhibitory effect of maternal antibody on mother-to-child transmission of human T-lymphotropic virus type I.Reviewed

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Books

  • Health and Medical Issues and Longevity in the Amami Island Region.

    Takezaki T, Niimura H, Kuwabara K.( Role: Joint author)

    In: Kawai K, Terada R, Kuwahara S, eds. The Islands of Kagoshima Kagoshima University Research Center for the Pacific Islands, Kagoshima  2013.3 

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    Language:English Book type:Scholarly book

  • Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma in a child.

    Nakazono S, Kitahara T, Takezaki T, Kawakami K, Hasui K, Satoh E, Tokunaga M( Role: Joint author)

    Acta Paediatrica Japonica  1991 

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    Language:English Book type:Report

MISC

  • An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate Reviewed International coauthorship International journal

    Nakatochi M.

    Rheumatology (Bulgaria)   60 ( 9 )   4430 - 4432   2021.9

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:Rheumatology (Bulgaria)  

    DOI: 10.1093/rheumatology/keab404

    Scopus

    PubMed

  • 医師修学資金貸与生が専門医を取得するのは現状では困難である

    根路銘安仁、大脇哲洋、嶽崎俊郎

    日医雑誌   143 ( 6 )   1223 - 1231   2014.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 鹿児島県における地域枠学生のキャリア計画時の問題点 Reviewed

    根路銘安仁、大脇哲洋、桑原和代、新村英士、嶽崎俊郎

    医学教育   44 ( 6 )   461 - 465   2013.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 日米の肺癌のリスク

    嶽崎俊郎

    THE LUNG perspectives   21 ( 1 )   77 - 81   2013.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • がん対策-途上国-

    嶽崎俊郎

    総合臨床   55 ( 3 )   453 - 459   2006.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 食道がん

    嶽崎俊郎

    田島和雄監修、古野純典、中地敬編、がん予防の最前線上基礎知識から新戦略へ.昭和堂:京都   52 - 58   2004.1

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Presentations

  • Ippei Shimoshikiryo, Rie Ibusuki, Keiichi Shimatani, Daisaku Nishimoto, Toshiro Takezaki, Kenji Wakai, the J-MICC Study Group   Comprehensive Unhealthy Lifestyle is associated with Alcohol Consumption as J-Shaped Curve   International conference

    12th European Public Health Conference  European Public Health Association

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    Event date: 2019.11

    Language:English   Presentation type:Poster presentation  

    Venue:Marseille, France  

  • R Ibusuki, I Shimoshikiryo, K Shimatani, D Nishimoto, S Maenohara, T Takezaki   Advancement of hepatic fibrosis among general women with/without NAFLD   International conference

    12th European Public Health Conference  European Public Health Association

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    Event date: 2019.11

    Language:English   Presentation type:Poster presentation  

    Venue:Marseille, France  

  • 西本大策、指宿りえ、下敷領一平、嶽崎俊郎、J-MICC Study Group   脂肪摂取制限に対する自己意識と実際の脂肪摂取量及び血清脂質値との関連に関する研究  

    第78回日本公衆衛生学会総会  日本公衆衛生学会

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    Event date: 2019.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:高知  

  • 下敷領一平、指宿りえ、西本大策、嶽崎俊郎、J-MICC Study Group   アルコール1日摂取量ごとの飲酒頻度と動脈硬化関連要因との関連に関する研究  

    第78回日本公衆衛生学会総会  日本公衆衛生学会

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    Event date: 2019.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:高知  

  • 指宿りえ、下敷領一平、西本大策、嶽崎俊郎   非アルコール性脂肪性肝疾患の経時的変化に関するコーホート研究  

    第78回日本公衆衛生学会総会  日本公衆衛生学会

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    Event date: 2019.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:高知  

  • 網谷真理恵、網谷東方、川元美穂子、浅川明弘、水間喜美子、指宿りえ、嶽崎俊郎、大脇哲洋   心身症を伴う不登校に対し、漢方治療、心理教育、学校連携実施による包括的治療により登校可能となった一例  

    第10回日本プライマリ・ケア連合学会学術会議  日本プライマリ・ケア連合学会

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都  

  • 大脇哲洋、網谷真理恵、水間喜美子、指宿りえ、嶽崎俊郎   医学科6年時の必修「離島・地域医療実習」の効果に関する経年的検討  

    第10回日本プライマリ・ケア連合学会学術会議  日本プライマリ・ケア連合学会

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都  

  • 三島 一乃、網谷真理恵、指宿りえ、下敷領一平、西本大策、大脇哲洋、嶽崎俊郎   離島住民の専門医療に対するニーズに関する研究  

    第10回日本プライマリ・ケア連合学会学術会議  日本プライマリ・ケア連合学会

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都  

  • Kimiko Mizuma, Marie Amitani, Suguru Kawazu, Rie Ibusuki, Toshirou Takezaki, Tetsuhiro Owaki   Exploring interdisciplinary healthcare professionals’ perspective on assessments related to patient discharge from a long-term care hospital with using the ICF   International conference

    WONCA Asia Pacific Regional Conference 2019  WONCA

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    Event date: 2019.5

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto  

  • Tetsuhiro Owaki, Marie Amitani, Kimiko Mizuma, Rie Ibusuki, Tshirou Takezaki   Study about the consciousness change for the regional medicine of the compulsory "remote island/regional medicine training   International conference

    WONCA Asia Pacific Regional Conference 2019  WONCA

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    Event date: 2019.5

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto  

  • Shin Ogawa, Hidehiro Tokuda, Yoshihiro Nozaki, Tomoyuki Mukai, Toshiro Takezaki   Dying at home in the village of 1,49 inhabitants   International conference

    WONCA Asia Pacific Regional Conference 2019  WONCA

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    Event date: 2019.5

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto  

  • 指宿りえ、下敷領一平 、Yora Nindita、西本大策、嶋谷圭一、前之原茂穂、嶽崎俊郎   一般住民女性における非アルコール性脂肪肝と肝線維化に関する前向き研究  

    第29回日本疫学会学術総会  日本疫学会学

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    Event date: 2019.1 - 2019.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京  

  • 下敷領一平、指宿りえ、嶋谷圭一、西本大策、嶽崎俊郎、J-MICC Study Group   日本人一般集団における種類別アルコール摂取とメタボリック症候群関連要因に関する横断的研究:J-MICC研究  

    第29回日本疫学会学術総会  日本疫学会学

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    Event date: 2019.1 - 2019.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京  

  • Yora Nindita, Masahiro Nakatochi, Rie Ibusuki, Keiichi Shimatani, Ippei Shimoshikiryo, Toshiro Takezaki   Interaction between genetic factors, and smoking and drinking habits for HDL-C levels from GWAS  

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    Event date: 2019.1 - 2019.2

    Language:English   Presentation type:Oral presentation (general)  

  • 望月礼子、服部純一、原純、中村健太郎、辻紘明、有嶋拓郎、嶽崎俊郎、垣花泰之   奄美大島の救急救命センターにおける小児受診動向解析:小児診療の教育ポイン  

    第46回日本救急医学会総会・学術集会  日本救急医学会

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    Event date: 2018.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:横浜  

  • 望月礼子、服部淳一、原純、森田喜紀、嶽崎俊郎   <奄美プロジェクト>奄美大島で各種コースを開催し研修医を呼ぶ試み  

    第22回へき地・離島救急医療学会学術集会  へき地・離島救急医療学会

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    Event date: 2018.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:長崎  

  • 嶽崎俊郎   地域医療の魅力をいかに伝えるか  

    第22回へき地・離島救急医療学会学術集会  へき地・離島救急医療学会

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    Event date: 2018.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:長崎  

  • 指宿りえ、下敷領一平、西本大策、嶽﨑俊郎   非アルコール性脂肪性肝疾患の経時的変化の男女差に関するコーホート研究  

    第77回日本公衆衛生学会総会  日本公衆衛生学会

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    Event date: 2018.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:郡山  

  • 下敷領一平、指宿りえ、西本大策、内藤真理子、若井建志、嶽﨑俊郎、J-MICC Study Group   日本人一般集団における飲酒量と健診結果の関連に関する横断的研究:J-MICC研究より  

    第77回日本公衆衛生学会総会  日本公衆衛生学会

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    Event date: 2018.10

    Language:English   Presentation type:Poster presentation  

    Venue:郡山  

  • 嶽崎俊郎   鹿児島県厚生連巡回健診の推移と地域差からみた現状と今後の展望  

    第28回九州農村医学会  九州農村医学会

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:鹿児島市  

  • 下敷領一平、指宿りえ、Yora Nindita、嶋谷圭一、桑原和代、中畑典子、新村英士、前之原茂穂、嶽崎俊郎   CAVI値の経年変化に影響を与える要因に関する研究  

    第28回日本疫学会学術総会 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福島市  

  • 辻雅善、 有馬久富、 大久保孝義、 中村幸志、 嶽崎俊郎、 坂田清美、 奥田奈賀子、 西信雄、 門田文、 岡村智教、 上島弘嗣、 岡山明、 三浦克之、 NIPPON DATA研究グループ   社会経済的水準と循環器疾患危険因子認知度との関連  

    第76回日本公衆衛生学会総会 

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    Event date: 2017.10 - 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島  

  • 嶽崎俊郎   離島住民の健康を支える医療人育成  

    第76回日本公衆衛生学会総会 

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    Event date: 2017.10 - 2017.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:鹿児島  

  • 嶽崎俊郎   鹿児島の離島へき地を利用した地域医療教育  

    第27回九州農村医学会 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:長崎市  

  • 田井村依里、網谷真理恵、根路銘安仁、大脇哲洋、嶽崎俊郎   トビタテ!留学JAPANプログラムで留学したインドネシアでの臨床および公衆衛生実習  

    第8回日本プライマリ・ケア連合学会学術大会 

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    Event date: 2017.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:髙松  

  • Ibusuki R, Takezaki T   Cross sectional study for the association between fatty liver advancement and atherosclerosis-related factors  

    Academic Meeting of Japanese Public Health Association  Japanese Public Health Association

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    Event date: 2016.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Osaka  

  • Ibusuki R, Shimatani K, Kairupan TS, Nindida Y, Shimoshikiryo I, Maenohara S, Takezaki T   Risk of nonalcoholic steatohepatitis among Japanese general population   International conference

    8th General Assembly of the Asian Pacific Organization for Cancer Prevention  Asian Pacific Organization for Cancer Prevention

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    Event date: 2016.4

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Brisbane  

  • Takezaki T, Shimatani K, Ito H, Tanaka H, Tajima K   Association of nicotine concentration and smoking habit with cigarette consumption among Japanese   International conference

    8th General Assembly of the Asian Pacific Organization for Cancer Prevention  Asian Pacific Organization for Cancer Prevention

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    Event date: 2016.4

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Brisbane  

  • Takezkai T   Health promotion using thalassotherapy   Invited

    Kyuushu Preventive Medicine Scientific Meeting  Kyuushu Preventive Medicine Association

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Kagoshima  

  • Takezaki T, Owaki T   Health Issues and Genome-cohort Study in Amami Island Region, Japan.   Invited International conference

    Seminar: Lesson Learned from Japan at Faculty of Public Health  Sam Ratulangi University

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    Event date: 2016.2

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Manado, Indonesia  

  • Tara Sefanya Kairupan, Rie Ibusuki, Eva Mariane Mantjoro, Hideshi Niimura, Kazuyo Kuwabara, Shin Ogawa, Noriko Nakahata, Yasuhito Nerome, Tetsuhiro Ohwaki, Ken Kusano, Toshiro Takezaki   Clinical and Lifestyle Characteristics associated with HTLV-1 Carrier among General Population  

    第24回日本疫学会学術総会  第24回日本疫学会学術総会

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    Event date: 2015.1

    Language:Japanese  

    Venue:名古屋  

    国内学会

  • 嶽崎俊郎   島嶼地域を活用した地域医療教育  

    第22回国保連合会地域医療学会鹿児島地方会  第22回国保連合会地域医療学会鹿児島地方会

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    Event date: 2014.11

    Language:Japanese  

    Venue:鹿児島市  

    研究会

  • Eva Mariane Mantjoro, Hideshi Niimura, Kazuyo Kuwabara, Hiroaki Kanouchi, Kusuke Toyoda, Motahare Kheradmand, Akihiko Nakamura, Shin Ogawa, Noriko Nakahata, Yasuhito Nerome, Tetsuhiro Ohwaki, Ken Kusano and Toshiro Takezaki   Effect of MTHFR polymorphism for homocysteine levels and arterial stiffness by food intake  

    第24回日本疫学会学術総会  第24回日本疫学会学術総会

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    Event date: 2014.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台  

    国内学会

  • 桑原和代、新村英士、中村昭彦、中畑典子、Motahare Kheradmand、 Mantjoro Eva Mariane、嶋谷圭一、小川信、根路銘安仁、大脇哲洋、草野健、杉山大典、岡村智教、嶽崎俊郎   あまみ島嶼地域における末梢動脈疾患の分布と要因に関する研究  

    第24回日本疫学会学術総会  第24回日本疫学会学術総会

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    Event date: 2014.1

    Language:Japanese  

    Venue:仙台  

    国内学会

  • 根路銘安仁、大脇哲洋、桑原和代、新村英士、嶽崎俊郎   鹿児島県における地域枠学生のキャリア計画時の問題点  

    第45回日本医学教育学会大会  第45回日本医学教育学会大会

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    Event date: 2013.7

    Language:Japanese  

    Venue:千葉  

    国内学会

  • Kenji Wakai, Haruo Mikami, Kiyonori Kuriki, Sadao Suzuki, Yoshikuni Kita, Yoshiyuki Watanabe, Kokichi Arisawa, Suminori Kono, Norihiro Furusho, Keitaro Tanaka, Toshiro Takezaki, Michiaki Kubo, Nobuyuki Hamajima and Hideo Tanaka for the J-MICC Study Group   The Japan Multi-institutional Collaborative Cohort (J-MICC) Study: its design and progress   International conference

    第9回日米癌合同会議  第9回日米癌合同会議

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    Event date: 2013.2

    Language:English  

    Venue:Hawai  

    国際学会

  • 嶋谷圭一,桑原和代1,新村英士,中村昭彦,立棒雅也,小川信,中畑典子,Motahare Kheradmand, Mantjoro Eva Mariane,根路銘安仁,大脇哲洋、草野健,嶽崎俊郎   日常身体活動量や運動習慣、海洋療法によるる動脈硬化要因及び医療費の改善に関する研究  

    第23回日本疫学会学術総会  第23回日本疫学会学術総会

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    Event date: 2013.1

    Language:Japanese  

    Venue:大阪  

    国内学会

  • 桑原和代,新村英士,中村昭彦,立棒雅也,小川信,中畑典子,Motahare Kheradmand, Mantjoro Eva Mariane,根路銘安仁,大脇哲洋、草野健,嶽崎俊郎   あまみ島嶼地域における動脈硬化とストレスに関する研究  

    第23回日本疫学会学術総会  第23回日本疫学会学術総会

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    Event date: 2013.1

    Language:Japanese  

    Venue:大阪  

    国内学会

  • Motahare Kheradmand, Hideshi Niimura, Kazuyo Kuwabara, Noriko Nakahata, Eva Mariane Mantjoro, Yasuhito Nerome, Tetsuhiro Ohwaki, Ken Kusano, Toshiro Takezaki   Association of polymorphisms in NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1 and TNF-α and environmental factors in the progression of atherosclerosis  

    第23回日本疫学会学術総会  第23回日本疫学会学術総会

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    Event date: 2013.1

    Language:Japanese  

    Venue:大阪  

    国内学会

  • 根路銘安仁、 桑原和代、大脇哲洋、新村英士、嶽崎俊郎、河野嘉文   鹿児島県のHTLV‐I母子感染対策の現状  

    第3回日本プライマリ・ケア連合学会学術集会  第3回日本プライマリ・ケア連合学会学術集会

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    Event date: 2012.9

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 新村英士、平佐田和代、中村昭彦、常松典子、小川信、千葉調、根路銘安仁、大脇哲洋、嶽崎俊郎   眼底所見(Scheie分類)を用いたCardio Ankle Vascular Index (CAVI)の妥当性に関する研究  

    第22回日本疫学会学術総会  第22回日本疫学会学術総会

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    Event date: 2012.1

    Language:Japanese  

    Venue:東京  

    国内学会

  • Motahare Kheradmand, Hideshi Niimura, Kazuyo Hirasada, Noriko Nakahata, Eva Mariane Mantjoro, Toshiro Takezaki   The change of CAVI values during 5 years among general population of an island of Kagoshima  

    第22回日本疫学会学術総会  第22回日本疫学会学術総会

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    Event date: 2012.1

    Language:Japanese  

    Venue:東京  

    国内学会

  • Katanoda K, Sobue T, Satoh H, Tajima K, Suzuki T, Nakatsuka H, Takezaki T, Nakayama T, Nitta H, Tanabe K, Tominaga S   Association between long-term exposure to ambient air pollution and mortality from lung cancer and respiratory diseases.  

    第70回日本癌学会総会  第70回日本癌学会総会

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    Event date: 2011.10

    Language:Japanese  

    Venue:名古屋  

    国内学会

  • 嶽崎俊郎   離島住民の健診をベースにした疫学研究  

    第21回九州農村医学会  第21回九州農村医学会

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    Event date: 2011.6

    Language:Japanese  

    Venue:鹿児島  

    国内学会

  • 平佐田和代、新村英士、中村昭彦、立棒雅也、小川信、常松典子、千葉調、嶽崎俊郎、窪薗琢郎、宮田昌明、松下俊文、草野健   あまみ島嶼地域と鹿児島県本土における動脈硬化の分布に関する比較研究  

    第21回日本疫学会学術総会  第21回日本疫学会学術総会

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    Event date: 2011.1

    Language:Japanese  

    Venue:札幌  

    国内学会

  • 中村昭彦、新村英士、嶽崎俊郎、久保充明、田中英夫、若井建志、浜島信之、J-MICC Study Group   血中HDLコレステロール濃度に関わる遺伝子多型及び生活習慣に関する横断研究  

    第21回日本疫学会学術総会  第21回日本疫学会学術総会

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    Event date: 2011.1

    Language:Japanese  

    Venue:札幌  

    国内学会

  • 新村英士、平佐田和代、中村昭彦、常松典子、小川信、千葉調、根路銘安仁、大脇哲洋、嶽崎俊郎   離島地域での罹患調査におけるレセプトを用いた郵送調査と医療機関調査の感度に関する研究  

    第21回日本疫学会学術総会  第21回日本疫学会学術総会

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    Event date: 2011.1

    Language:Japanese  

    Venue:札幌  

    国内学会

  • Akihiko Nakamura, Yasuko Sagara, Nobuyuki Hamajima, Kazunari Yamaguchi, Toshiro Takezaki   Comparison of HTLV-I seroprevalence between blood donors and health checkup examinees in an island region, Japan.  

    第69回日本癌学会総会  第69回日本癌学会総会

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    Event date: 2010.9

    Language:Japanese  

    Venue:大阪  

    国内学会

  • Ji Young Park, Toshiro Takezaki, Hidemi Ito, Akihiko Nakamura, Keitaro Matsuo, Hideo Tanaka, Hiroshi Ogawa, Kazuo Tajima, Kunio Aoki   Does the change to the type of cigarette from non-filter to filter contribute to the decrease of the lung cancer risk?  

    第69回日本癌学会総会  第69回日本癌学会総会

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    Event date: 2010.9

    Language:Japanese  

    Venue:大阪  

    国内学会

  • 根路銘安仁、大脇哲洋、新村英士、嶽崎俊郎   卒前地域医療教育は興味のない学生の関心を高める  

    第42回日本医学教育学会大会  第42回日本医学教育学会大会

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    Event date: 2010.7

    Language:Japanese  

    Venue:東京  

    国内学会

  • 大脇哲洋、根路銘安仁、新村英士、夏越祥次、嶽崎俊郎   国の地域医療再生計画に見る、地域医療教育と地域推薦枠医学生の問題点  

    第42回日本医学教育学会大会  第42回日本医学教育学会大会

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    Event date: 2010.7

    Language:Japanese  

    Venue:東京  

    国内学会

  • 今道英秋、浅井康文、大田宣弘、米倉正大、嶽崎俊郎、中村好一、井上和男、杉田義博、鈴川正之   大病院に勤務する医師の総合診療に対する指向の状況と影響する因子の検討  

    第1回日本プライマリ・ケア連合学会学術集会  第1回日本プライマリ・ケア連合学会学術集会

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    Event date: 2010.6

    Language:Japanese  

    Venue:東京  

    国内学会

  • 大脇哲洋、根路銘安仁、新村英士、鎌村好孝、夏越祥次、嶽崎俊郎   全国の地域推薦枠医学生の増加とその問題点  

    第1回日本プライマリ・ケア連合学会学術集会  第1回日本プライマリ・ケア連合学会学術集会

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    Event date: 2010.6

    Language:Japanese  

    Venue:東京  

    国内学会

  • 根路銘安仁、大脇哲洋、新村英士、嶽崎俊郎   全国希望医学生に対する夏季離島医療実習の効果  

    第1回日本プライマリ・ケア連合学会学術集会  第1回日本プライマリ・ケア連合学会学術集会

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    Event date: 2010.6

    Language:Japanese  

    Venue:東京  

    国内学会

  • 嶽崎俊郎   地域のリソースを生かした開発途上国との接点の構築  

    第28回国際保健医療学会西日本大会  第28回国際保健医療学会西日本大会

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    Event date: 2010.3

    Language:Japanese  

    Venue:長崎  

    国内学会

  • 嶽崎俊郎   離島における地域包括医療について  

    第16回日本行動医学会学術総会  第16回日本行動医学会学術総会

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    Event date: 2010.2

    Language:Japanese  

    Venue:指宿  

    国内学会

  • 大脇哲洋、根路銘安仁、新村英士、嶽﨑俊郎   鹿児島県でのドクターヘリの可能性  

    第13回へき地・離島救急医療研究会学術集会  第13回へき地・離島救急医療研究会学術集会

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    Event date: 2009.10

    Language:Japanese  

    Venue:和歌山  

    国内学会

  • 今道英秋、浅井康文、嶽﨑俊郎、大田宣弘、米倉正大、井上和男、鈴川正之   へき地の診療所における後方医療機関への搬送の状況および問題点の分析  

    第13回へき地・離島救急医療研究会学術集会  第13回へき地・離島救急医療研究会学術集会

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    Event date: 2009.10

    Language:Japanese  

    Venue:和歌山  

    国内学会

  • 根路銘安仁、大脇哲洋、、小川 信、中村昭彦、平佐田和代、常松典子、新村英士、嶽崎俊郎   皆既日食ツアー時におけるトカラ列島の救急医療体制-島民、ツアー参加者、医療者からの評価-  

    第13回へき地・離島救急医療研究会学術集会  第13回へき地・離島救急医療研究会学術集会

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    Event date: 2009.10

    Language:Japanese  

    Venue:和歌山  

    国内学会

  • 平佐田和代、宮薗夏美、下敷領須美子、嶽崎俊郎   大洋州諸国におけるProblem Treeを用いた問題解決型プログラム  

    第24回日本国際保健医療学会学術大会  第24回日本国際保健医療学会学術大会

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    Event date: 2009.8

    Language:Japanese  

    Venue:仙台  

    国内学会

  • 新村英士、平佐田和代、中村昭彦、小川信、常松典子、立棒雅也、竹内亨、嶽崎俊郎   長寿者におけるDNA酸化産物と生活習慣およびDNA修復遺伝子多型に関する研究  

    第19回日本疫学会学術総会  第19回日本疫学会学術総会

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    Event date: 2009.1

    Language:Japanese  

    Venue:石川  

    国内学会

  • 中村昭彦、平佐田和代、小川信、常松典子、立棒雅也、新村英士、嶽崎俊郎   鹿児島研あまみ島嶼地域住民における血中脂質に関する横断的研究  

    第19回日本疫学会学術総会  第19回日本疫学会学術総会

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    Event date: 2009.1

    Language:Japanese  

    Venue:石川  

    国内学会

  • 平佐田和代、中村昭彦、小川信、常松典子、立棒雅也、新村英士、嶽崎俊郎   あまみ島嶼地域における動脈硬化に関する横断的研究  

    第19回日本疫学会学術総会  第19回日本疫学会学術総会

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    Event date: 2009.1

    Language:Japanese  

    Venue:石川  

    国内学会

  • 嶽崎俊郎   離島へき地医療教育における大学の役割  

    第12回へき地・離島救急医療研究会学術集会  第12回へき地・離島救急医療研究会学術集会

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    Event date: 2008.10

    Language:Japanese  

    Venue:鹿児島  

    研究会

  • Takezaki T   Molecular epidemiological study in islands with longevity and gene polymorphism prevalence among population of advanced age  

    The Japan-Korea Joint Seminar (AACL2008): Toward the establishment of Asian Aging Research and Education Center  The Japan-Korea Joint Seminar (AACL2008): Toward the establishment of Asian Aging Research and Education Center

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    Event date: 2008.9

    Language:Japanese  

    Venue:長崎  

    その他

  • 嶽崎俊郎、新村英士、平佐田和代、小川信、常松典子、中村昭彦、立棒雅也   あまみ離島地域における生活習慣と健診結果-分子疫学研究への展開-  

    鹿児島農村医学研究会第40回中央研究集会  鹿児島農村医学研究会第40回中央研究集会

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    Event date: 2008.8

    Language:Japanese  

    Venue:鹿児島  

    研究会

  • 中村昭彦、小川信、平佐田和代、常松典子、根路銘安仁、大脇哲洋、新村英士、今道英秋、鈴川正之、嶽崎俊郎   鹿児島県離島における母子および小児の保健・医療に関する満足度と受診行動  

    第32回日本プライマリ・ケア学会学術会議2008岡山  第32回日本プライマリ・ケア学会学術会議2008岡山

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    Event date: 2008.6

    Language:Japanese  

    Venue:岡山  

    国内学会

  • 小川信、中村昭彦、平佐田和代、常松典子、根路銘安仁、大脇哲洋、新村英士、今道英秋、鈴川正之、嶽崎俊郎   鹿児島県離島における一般住民の医療に対する満足度および受診行動  

    第32回日本プライマリ・ケア学会学術会議2008岡山  第32回日本プライマリ・ケア学会学術会議2008岡山

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    Event date: 2008.6

    Language:Japanese  

    Venue:岡山  

    国内学会

  • Takezaki T   Field Study for Lifestyle-related Disease Prevention in Kagoshima Island Region and Education Program Development of Public Health Experts  

    Symposium for Education Program Development of Public Health Experts on Island and Community Medicine with a Focus on Islamic Countries  Symposium for Education Program Development of Public Health Experts on Island and Community Medicine with a Focus on Islamic Countries

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    Event date: 2008.3

    Language:Japanese  

    Venue:鹿児島  

    その他

  • Takezaki T   Dietary factor for reduction of arteriosclerosis development in Kagoshima island region  

    ICPH Satellite Symposium “Food and Health”  ICPH Satellite Symposium “Food and Health”

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    Event date: 2007.11

    Language:Japanese  

    Venue:鹿児島  

    その他

  • 嶽崎俊郎   鹿児島大学における離島へき地医療人育成センターの新設  

    第15回鹿児島県国保地域医療学会  第15回鹿児島県国保地域医療学会

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    Event date: 2007.11

    Language:Japanese  

    Venue:鹿児島  

    国内学会

  • 嶽崎俊郎(Takezaki Toshiro)   鹿児島県離島地域における分子疫学研究の展開:初回調査応答率の検討  

    第16回日本疫学会学術総会(Sixty-Fifth Annual Meeting of the Japanese Epidemiological Association)  第16回日本疫学会学術総会(Sixty-Fifth Annual Meeting of the Japanese Epidemiological Association)

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    Event date: 2006.1

    Language:Japanese  

    Venue:愛知  

    国内学会

  • 平佐田和代、古川誠二、大坪充寛、吉田紀子、嶽崎俊郎   海洋療法の不定愁訴に及ぼす効果に関する介入研究  

    第64回日本公衆衛生学会総会  第64回日本公衆衛生学会総会

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    Event date: 2005.9

    Language:Japanese  

    Venue:北海道  

    国内学会

  • 嶽崎俊郎(Takezaki Toshiro)   中国江蘇省における大腸がんの間環境要因に関する症例・対照研究(Case-control study for environmental factors of colorectal cancer in Jiangsu Province China)  

    第63回日本癌学会学術総会(Sixty-Thied Annual Meeting of the Japanese Cancer Association)  第63回日本癌学会学術総会(Sixty-Thied Annual Meeting of the Japanese Cancer Association)

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    Event date: 2004.10

    Language:Japanese  

    Venue:神奈川  

    国内学会

  • 園田純一郎,郡山千早,嶽崎俊郎(Takezaki Toshiro),小迫知弘,秋葉澄伯(AKIBA SUMINORI),園田俊郎   緑茶カプセル服用によるHTLV-1キャリアの抹消血リンパ球HTLV-1プロウイルス量の減少効果(Effect of green tea extract capsule on HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers)  

    第63回日本癌学会学術総会(Sixty-Thied Annual Meeting of the japanese Cancer Association)  第63回日本癌学会学術総会(Sixty-Thied Annual Meeting of the japanese Cancer Association)

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    Event date: 2004.9

    Language:Japanese  

    Venue:神奈川  

    国内学会

  • Yasuda Tomoko, Takezaki Toshiro, Nishimoto Daisaku, Ibusuki Rie   奄美における郷土野菜と死亡率および癌罹患リスクの低下(Local vegetables and decreased risk of mortality and cancer incidence in Amami)  

    日本公衆衛生学会総会抄録集  2021.11  日本公衆衛生学会

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    Language:English  

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Research Projects

  • HTLV-Iキャリアにおける全死亡リスクに対する防御要因に関する研究

    Grant number:J200000191  2020.4

    科学研究費補助金  基盤研究(C)

    嶽﨑俊郎

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Human T cell leukemia virus type I(HTLV-I)陽性者において全死亡リスクが上昇していることが報告されている。本研究の目的は、HTLV-Iキャリアにおける高い全死亡リスクに対する防御要因をコーホート研究において明らかにすることである。さらに、炎症性サイトカインおよびHLAハプロタイプに関わる遺伝子多型を用いて高感受性群における防御要因も明らかにする。対象は鹿児島県の島嶼地域と農村地域で行われているコーホート研究の参加者である健診受診一般集団のうちHTLV-I抗体測定が行われている男女7,210名(陽性率6.4%)で、新学術領域研究「コホート・生体試料支援プラットフォーム」の支援を受けて疫学情報とDNAの提供を受けて行う。これまでにHTLV-Iキャリアにおける全死亡リスク上昇に関わる環境要因の報告はなく、本研究により全死亡リスク軽減に有効な新たな知見を提供することができる。

  • コホート・生体試料支援プラットフォーム

    Grant number:16H06277  2016.4 - 2022.3

    文部科学省  科学研究費補助金  新学術領域研究

    嶽﨑俊郎

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\63310000 ( Direct Cost: \48700000 、 Indirect Cost:\14610000 )

    生体試料支援 / コホート / 一般健常人 / 大規模ゲノム解析

  • NAFLD経過における脂肪肝表現型と肝線維化に関する研究

    Grant number:19K10624  2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    非アルコール性脂肪性肝疾患は、肥満人口や生活習慣病と伴に増加しており、メタボリック症候群を高率に合併し、一部は脂肪性肝炎から肝硬変・肝癌に進展する。また、性・年齢分布は男女で異なる特徴があり、NAFLDの進展度に影響する要因に関するエビデンスは限られている。
    本研究では、一般住民における非アルコール性脂肪性肝疾患の脂肪肝の経過における表現型と肝線維化に関わる要因について明らかにし、個別化予防対策に質することを目的として、日本多施設共同コーホート研究に参加し腹部超音波検査を受けている研究協力者を対象に、横断的及び前向きに分子疫学研究を行う。

  • 離島・農村地域における効果的な生活習慣病対策の運用と展開に関する研究

    2009.4 - 2012.3

    厚生労働省  科学技術振興調整費 

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    Grant type:Competitive

  • 現状に即したへき地等の保健医療を構築する方策および評価指標に関する研究

    2007.4 - 2010.3

    厚生労働省  科学技術振興調整費 

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    Grant type:Competitive

    へき地等の保健医療を構築する方策および評価指標を開発する。

  • がん情報ネットワークを利用した総合的がん対策支援の具体的方法に関する研究

    2005.4 - 2008.3

    厚生労働省  科学技術振興調整費 

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    Grant type:Competitive

    がん疫学研究におけるインターネットを利用した情報提供支援

  • 持続可能なへき地等における保健医療を実現する方策に関する研究

    2004.4 - 2007.3

    厚生労働省  科学技術振興調整費 

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    Grant type:Competitive

    持続可能なへき地等における保健医療を実現する方策を、実際にへき地医療機関への調査内容をもとに検討する。

  • JICA地域別研修事業「島嶼地域における地域保健から学ぶ生活習慣病対策」

    2019.10

    独立行政法人 国際協力機構  JICA課題別研修事業 

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    島嶼地域における地域保健から学ぶ生活習慣病対策

  • JICA地域別研修事業

    2018.10 - 2018.11

    政府機関 

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    島嶼地域における生活習慣病対策から学ぶ地域保健強化

  • HTLV-1性行為感染後の母子感染の機序解明と保健指導の開発

    2017.3 - 2020.3

    科学研究費補助金  基盤研究(C)

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    本研究では、HTLV-1キャリア男性およびその配偶者への①保健指導マニュアルの作成、②性行為感染後の抗体価・プロウイルス量の推移の測定を行い、測定項目・時期の提案を目的としている。

  • Study for the stress and NCD prevention by thalassotherapy

    2016.5 - 2017.3

    Local Government  General Consignment Study 

  • 一般住民における非アルコール性脂肪肝の進展に関する分子疫学研究

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

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    一般集団における非アルコール性脂肪性肝疾患(NAFLD)の進展に関わる環境・宿主要因を明らかにするために、横断的及び前向きに分子疫学研究を行った。対象者は、日本多施設共同コーホート研究に参加し腹部超音波検査を受けている研究協力者6,609名である。
    近年、増加傾向にあるNAFLDの分布は、年齢と伴に上昇するものの50-60歳代にピークがあり、その後は低下していることが報告されている。本研究では、NAFLDは消失しても線維化は改善せず、加齢に伴う進行が上載せされる形で年齢と伴に肝線維化進展は持続していることが示唆され、NAFLD発生を防ぐことが肝繊維化予防のためにも重要であることが示された。

  • 都市と離島におけるCAVIを用いた動脈硬化性疾患に寄与する危険因子の研究

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

    桑原和代

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    脳・心血管疾患の発症率には地域差があることが知られているが、主要な原因である動脈硬化所見やその進展要因の集団間の差についてはあまり明らかにされていない。そこで動脈硬化の代理指標としてcardio ankle vascular index; CAVIを用い、神戸と鹿児島の地域住民の比較を行った。両地域とも閉経後にCAVIが高く、年齢、収縮期血圧がCAVI高値の規定要因であったがこれらを調整しても鹿児島のCAVIは神戸より高かった。更に職域健診のデータを用いて縦断的な解析を行い、勤務者においては動脈硬化の危険因子のうち年齢、収縮期血圧の他にHbA1cがCAVIの上昇に寄与していることが示唆された。

  • 生活習慣に影響する遺伝要因の解析とメンデルランダム化による生活習慣病コホート研究

    2015.4 - 2019.3

    科学研究費補助金  基盤研究(A)

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    分子遺伝疫学 / 生活習慣 / 遺伝子多型 / GWAS / ゲノムワイド関連分析 / 日本多施設共同コーホート研究

  • JICA地域別研修事業

    2013.4 - 2014.3

    民間企業 

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    アジア・大洋州島嶼地域 問題解決型の保健専門職人材育成

  • 一般住民を対象にした遺伝子多型による運動効果の影響に関する比較疫学研究

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    運動 / 日常身体活動 / 海洋療法 / 医療費 / 遺伝子多型 / 動脈硬化

  • JICA地域別研修事業

    2012.4 - 2013.3

    政府機関 

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    アジア・大洋州島嶼地域 問題解決型の保健専門職人材育成

  • JICA地域別研修事業

    2010.11 - 2010.12

    政府機関 

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    大洋州地域保健医療における包括的予防対策

  • がん研究分野の特性等を踏まえた支援活動

    2010.4 - 2016.3

    科学研究費補助金  新学術領域研究

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    ゲノムコーホート研究 / 個別化がん予防 / 分子疫学コーホート研究

  • あまみ長寿地域における動脈硬化の経時変化に関する環境・宿主要因の研究 研究課題

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(C)

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    あまみ島嶼地域住民における動脈硬化分布の地域差を動脈硬化の代理指標である CAVI を用いて検討したところ、あまみの CAVI値は鹿児島県本土住民および日本人健常集団より低かった。動脈硬化要因に明らかな地域差は認められず、同要因を調整後もCAVI 値は地域差に関連していた。CAVI 値を SNPsごとに比較すると、男性では CD14 C-260T 多型の CC 型で CAVI 値が他の型より低く、動脈硬化危険因子を調整した重回帰分析では、34-49歳の若年男性群で CD14 C-260T 多型と CAVI値に正の関連を認めた。SNPs と 5 年間の CAVI 値経時変化に関連はなかった。

  • JICA地域別研修事業

    2009.4 - 2010.3

    政府機関 

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    大洋州地域 保健医療における包括的予防対策

  • JICA地域別研修事業

    2008.4 - 2009.3

    政府機関  一般受託研究 

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    大洋州地域 保健医療における包括的予防対策

  • あまみ長寿地域における動脈硬化進展予防に関する環境・宿主要因の研究

    2007.4 - 2009.3

    科学研究費補助金  基盤研究(C)

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    あまみ長寿地域で一般住民に対し動脈硬化・長寿に関わる研究を行った。動脈硬化は高年齢、高い最高血圧、空腹時高血糖、飲酒者、ヤセた人で多かった。酸化ストレスによるDNAの障害は加齢とともに上昇しており、89歳以下では喫煙などの生活習慣に影響されていたが、90歳以上では関係がなかった。DNAの障害を修復する酵素の個人差を遺伝子で分類すると90歳以上の健康長寿者で働きが弱い型を持つ者の割合が65歳未満の人に比べ小さく、長寿に関係している可能性が考えられた。

  • JICA草の根技術協力事業

    2007.1 - 2007.2

    政府機関 

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    離島医療

  • JICA草の根技術協力事業

    2006.1 - 2006.3

    政府機関 

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    離島医療

  • 日・中・韓三国で増加するがんの環境・宿主要因に関する民族疫学的研究

    2005.4 - 2010.3

    科学研究費補助金  特定領域研究

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    乳・大腸がんは日・中・韓三国で増加しつつあり、その環境・宿主要因を分子疫学的に解明し、三国における予防対策に寄与することを本研究課題の主目的と定め、平成17年度より五年計画で第二次三国共同研究を推進した。乳・大腸がんの三国における一般的増加要因を確認し、さらに、乳がんでは十分な大豆製品や葉酸の摂取が危険度を下げ、遺伝的にFGFR2の過剰発現群では肥満傾向や角経早期開始などの影響が大きいことなどを鮮明にした。

  • 分子疫学コーホート研究の支援に関する研究

    2005.4 - 2010.3

    科学研究費補助金  特定領域研究

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    コーホート研究 / 生活習慣病 / がん / 遺伝子型 / 生体指標 / 交互作用

  • JICA草の根技術協力事業

    2005.2 - 2005.4

    政府機関 

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    離島医療

  • 離島地域における生活習慣病予防に関する分子疫学研究

    2005

    補助金 

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    Grant type:Competitive

  • JICA草の根技術協力事業

    2004.4 - 2004.6

    政府機関 

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    離島医療

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Other research activities

  • NAFLD経過における脂肪肝表現型と肝線維化に関する研究

    2019.4

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    当教室の指宿りえ助教が獲得した科研費基盤研究(C)の研究を研究分担者として支援する。

  • 一般住民における非アルコール性脂肪肝の進展に関する分子疫学研究

    2016.4
    -
    2019.3

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    本学医歯研の指宿りえ助教が獲得した科研費基盤研究(C)の研究を研究分担者として支援する。

  • HTLV-1性行為感染後の母子感染の機序解明と保健指導の開発

    2017.3
    -
    2021.3

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    本学保健学科の根路銘安仁教授が獲得した科研費基盤研究(C)の研究を研究分担者として支援する。

  • あまみ長寿地域における動脈硬化の経時変化に関する環境・宿主要因の研究

    2010.4
    -
    2013.3

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    当教室の新村英士講師が獲得した科研費基盤研究(C)を研究分担者として支援する。

  • あまみ長寿地域における動脈硬化進展予防に関する環境・宿主要因の研究

    2007.4
    -
    2009.3

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    当教室の新村英士講師が獲得した科研費基盤研究(C)を研究分担者として支援する。

  • 食事記録調査の精度向上を目指した調査支援ツールのモデル設計とそのシステム開発

    2012.4
    -
    2016.3

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    ゲノムコーホート研究の共同研究者である今枝奈保美准教授(名古屋女子大学)が獲得した科研費基盤研究(C)に対し、データ提供を通じて共同研究を進捗する。

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Social Activities

  • 国際協力活動に関する市民公開講座

    Role(s): Planner, Organizing member

    鹿児島県JICA派遣専門家連絡会  2023.1

  • 医療フォーラム 瀬戸内町

    Role(s): Lecturer

    瀬戸内町、鹿児島大学機能強化事業  2022.11

  • 出前授業

    Role(s): Lecturer

    鹿児島県立甲南高校  2022.11

  • 南さつま市住民説明会

    Role(s): Lecturer, Planner, Organizing member

    南さつま市、鹿児島大学病院 地域医療支援センター  2022.10

  • 国際協力活動に関する市民公開講座

    Role(s): Planner, Organizing member

    2022.1

  • 国際協力活動に関する市民公開講座

    Role(s): Planner, Organizing member

    鹿児島県JICA派遣専門家連絡会  2021.1

  • 出前授業

    Role(s): Lecturer

    鹿児島玉龍高等学校  2020.11

  • 出前授業

    Role(s): Lecturer

    宮崎県立都城西高等学校  2020.11

  • 国際協力活動に関する市民公開講座

    Role(s): Planner, Organizing member

    鹿児島県JICA派遣専門家連絡会  2020.1

  • 市民公開講座 in 奄美市

    Role(s): Lecturer

    岩手医大  奄美市・奄美文化センター  2019.11

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    Audience: General, Governmental agency

    Type:Lecture

    あまみの生活習慣病予防と長寿に関する研究の紹介と生活習慣病予防に関する啓発

  • 国際協力活動に関する市民公開講座

    Role(s): Lecturer

    鹿児島県JICA派遣専門家連絡会  鹿児島市・天文館ビジョンホール  2019.1

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    Audience: High school students, College students, Graduate students, General

    国際協力への理解に関する市民への広報活動、テーマは「中国でのポリオ撲滅活動、そして南米のHTLV-Iを探して」

  • 出前授業

    Role(s): Lecturer

    鹿児島県立鶴丸高校  2017.10

  • 出前授業

    Role(s): Lecturer

    鹿児島県立種子島中央高校  2017.7

  • Open seminar for international cooperation activity

    Role(s): Presenter, Organizing member

    Kagoshima JICA Ecpert Association  2017.1

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    Audience: Junior students, High school students, College students, Graduate students, Teachers, General, Governmental agency

    Type:Seminar, workshop

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Media Coverage

  • 医療フォーラム 瀬戸内町 Newspaper, magazine

    奄美新聞  2022.11

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    Author:Other 

  • 国際協力活動に関する市民公開講座

    鹿児島県JICA派遣専門家連絡会  2018.1

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    国際協力への理解に関する市民への広報活動