Updated on 2026/05/26

写真a

 
UTO Akari
 
Organization
University Hospital, Medical and Dental Sciences Area University Hospital Clinical Center Anesthesia and Critical Care Center Assistant Professor
Title
Assistant Professor
Degree
(2024.11 Kagoshima University)

Research History

  • 2024.1    Kagoshima University   University Hospital, Medical and Dental Sciences Area University Hospital Clinical Center Anesthesia and Critical Care Center   Assistant Professor

Qualification acquired

  • 日本歯科麻酔学会認定医

 

Papers

  • Yamashita K., Yoshimine S., Uto A., Uchino M., Kibe T., Sugimura M. .  Effect of Local Anesthesia at the Bone Collection Site of Iliac Bone Grafting on Autonomic Nervous System Activity and Circulatory Dynamics in Alveolar Cleft Treatment .  Pain Research and Management2026 ( 1 ) e1837287   2026

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    Language：Japanese   Publisher：Pain Research and Management  

    Background: In alveolar bone graft surgery, local administration of ropivacaine at the iliac bone donor site is expected to have an analgesic effect. However, its effects on autonomic nervous system activity and circulatory dynamics are unknown. Aims: This study aimed to assess the effects of local ropivacaine administration to the iliac region under general anesthesia by analyzing changes in autonomic nervous system activity and circulatory dynamics. Methods: We retrospectively reviewed medical records of patients who underwent iliac bone grafting under general anesthesia between May 2021 and December 2022. At the end of surgery, ropivacaine was administered locally in the iliac region. Heart rate variability (HRV), heart rate (HR), and systolic blood pressure (SBP) were analyzed 5 min prior to (baseline) and 5 min following (postadministration) ropivacaine administration. Results: Seventeen patients were included in the analysis. The low/high frequency ratio was significantly elevated after ropivacaine administration compared with baseline (p < 0.05). No significant changes were observed in high frequency, HR, or SBP (p < 0.05). Conclusion: Local administration of ropivacaine in the iliac region under general anesthesia resulted in detectable neurological changes, as evidenced by HRV analysis, though conventional circulatory parameters remained unchanged. HRV may provide sensitive detection of perioperative stress beyond what is captured by hemodynamic measures alone.

    DOI： 10.1155/prm/1837287

    Scopus

    PubMed

  • Yoshimine S, Yamashita K, Higa Y, Uto A, Sugimura M .  Monitor feedback versus instructor feedback for post-pandemic basic life support training: a randomized controlled trial among dental students. .  BMC medical education25 ( 1 ) 918   2025.7

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    Language：English   Publisher：BMC Medical Education  

    Background: Dentists must provide basic life support (BLS) until the arrival of emergency services. Improving educational quality and expanding training opportunities in dental schools can enhance patient survival rates. Traditionally, primary life support training for dental students was conducted in person; however, in-person practice has become challenging during the recent coronavirus disease (COVID-19) pandemic caused by the novel coronavirus. Our objective was to examine how monitor feedback from a cardiopulmonary resuscitation (CPR) simulator and monitoring equipment, versus instructor feedback, affects the quality of BLS training for dental students, and to evaluate effective self-study methods during the pandemic. Methods: All participants (n = 40) underwent a pretraining test to assess their baseline technical skills in providing CPR. The students were then randomly divided into the following two groups: monitor feedback and instructor feedback. After the training, a post-test was administered using the same method as that used for the pretest. We statistically analyzed changes in chest compression (CC) depth, CC rate, CC fraction, and tidal volume before and after training in the two groups. Results: The analysis included 34 participants (17 per group) after excluding those lost to attrition. In the monitor feedback group, compared with the pretest, the post-test revealed a significantly improved CC depth. Meanwhile, the CC rate improved significantly in the instructor feedback group. Regarding CC depth, monitor feedback led to improved compression depth compared to instructor feedback. Conversely, instructor feedback on the CC rate led to superior results compared to monitor feedback. Conclusions: Training programs should provide monitor feedback for CC depth and instructor feedback on the CC rate to establish more effective self-study training methods. Different feedback types influence specific aspects of CPR and that further validation is required.

    DOI： 10.1186/s12909-025-07480-5

    Scopus

    PubMed

  • Yamashita K., Kibe T., Uto A., Yoshimine S., Uchino M., Sugimura M. .  Music and sedation relieve intraoperative stress: A randomized controlled trial .  Plos One20 ( 5 May ) e0325038   2025.5

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    Language：Japanese   Publisher：Plos One  

    Music is useful for relieving anxiety; however, its impact on autonomic nervous system activity and circulatory dynamics during tooth extraction surgery under intravenous sedation is unclear. We conducted a prospective randomized controlled trial to compare the effects of music listening on circulatory dynamics and autonomic nervous system activity during the extraction of impacted mandibular third molars under intravenous sedation. We hypothesized that music listening combined with intravenous sedation would enhance stress reduction. In this randomized controlled trial, 34 women aged 20–40 years were assigned to a music or control group. Patients in the music group listened to music during tooth extraction under intravenous sedation. Autonomic nervous system activity, heart rate, and systolic blood pressure were assessed in both groups. Statistical significance was set at p < 0.05. Systolic blood pressure and autonomic nervous system activity were not significantly different between the two groups. However, the heart rate during the separation of the tooth crown, extraction, and suturing was significantly lower in the music group than in the control group (p < 0.05). Within-group systolic blood pressure comparisons showed significant differences during treatments between the groups. Intraoperative music listening may enhance the stress-reducing effects of intravenous sedation, as auditory intervention attenuates blood pressure variability and increments in heart rate even when the level of consciousness is reduced by sedation. The combination of intravenous sedation and music listening may be useful for reducing stress during dental treatment.

    DOI： 10.1371/journal.pone.0325038

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    PubMed

  • Yamashita K., Kibe T., Yoshimine S., Uto A., Uchino M., Sugimura M. .  Case Report: A case series: heart rate variability during dental treatment with vasovagal reflex .  Frontiers in Physiology16   1607816   2025

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    Language：Japanese   Publisher：Frontiers in Physiology  

    Introduction: The vasovagal reflex is the most frequent emergency that occurs during dental procedures, but its underlying mechanism is not understood. In this study, we conducted autonomic monitoring of patients with a history of vasovagal reflexes. Case description: We focused on the high-frequency component, an indicator of parasympathetic activity, and interrupted the treatment when the high-frequency component increased. Treatment was then resumed after confirming that there was no mood disturbance and no increase in the high-frequency component. In another patient with a history of dental treatment-induced vasovagal reflex, autonomic activity during treatment was measured under atropine sulfate hydrate administration. Discussion: Analysis of heart rate variability during the vasovagal reflex showed that parasympathetic hyperactivity was followed by sympathetic hyperactivity, indicating real-time changes in autonomic nervous system activity. In addition, the high-frequency component, which decreased after atropine sulfate hydrate administration, did not increase during treatment, along with the low-frequency to high-frequency ratio, a measure of sympathetic nervous system activity, and the vasovagal reflex did not occur. We believe that the visualization of a patient’s autonomic nervous system activity during dental treatment will improve the quality of systemic management and lead to the realization of a safe and comfortable treatment environment.

    DOI： 10.3389/fphys.2025.1607816

    Scopus

    PubMed

  • Kaoru Yamashita, Shusei Yoshimine, Akari Uto, Minako Uchino, Toshiro Kibe, Mitsutaka Sugimura .  Screening Female Patients With Autonomic Nervous System Imbalance Using the Toho Medical Index Before Tooth Extraction .  Cureus16 ( (12) ) e76345   2024.12Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Akari Uto, Kaoru Yamashita, Shusei Yoshimine, Minako Uchino,Toshiro Kibe, Mitsutaka Sugimura .  Analysis of perioperative autonomic nervous system activity to visualize stress in pediatric patients undergoing alveolar bone graft surgery .  Journal of Clinical Monitoring and Computing39 ( 1 ) 45 - 52   2024Reviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10877-024-01210-w

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    PubMed

  • Kaoru Yamashita, Akari Uto, Minako Uchino, Toshiro Kibe, Mitsutaka Sugimura .  Listening to music before tooth extraction attenuates sympathetic nervous system activity: A randomized control trial .  Oral Science International20 ( 2 ) 88 - 94   2023.5Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/osi2.1151

    Scopus

  • YAMASHITA Kaoru, SHIDOU Rumi, YUTOKU Miyoko, UTO Akari, YOSHIMINE Shusei, SUGIMURA Mitsutaka .  Systemic Management Using Intravenous Sedation in a Patient with Multiple Chemical Sensitivities and Dentophobia .  Journal of Japanese Dental Society of Anesthesiology51 ( 1 ) 4 - 6   2023.1Reviewed

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Dental Society of Anesthesiology  

    <p>  Multiple chemical sensitivity is a disease in which autonomic and neuropsychiatric symptoms, such as fatigue, headache, joint pain, insomnia, and dermatitis, occur in response to exposure to a trace amount of a chemical substance. Here, we report the management of intravenous sedation for tooth extraction and caries treatment in a patient with multiple chemical sensitivities.</p><p>  A 57-year-old woman visited a nearby dental clinic complaining of dentin hypersensitivity and requiring tooth extraction and treatment for a root fracture in the mandibular right second molar and caries in the mandibular right first premolar. However, she had a history of chemical hypersensitivity and dentophobia. She was referred to our hospital and was scheduled to undergo intravenous sedation in an environment with minimal exposure to inducers.</p><p>  We monitored her blood pressure, percutaneous arterial oxygen saturation (SpO<sub>2</sub>), and pulse, and a single dose of midazolam (2 mg) and propofol (10 mg) was administered after securing an intravenous route. The continuous administration of propofol was started at 3 mg/kg/h under 3 L/min of oxygen after the patient fell asleep. No symptoms or risks associated with multiple chemical sensitivity were observed during the tooth extraction or caries treatment.</p><p>  The patient was successfully treated in an environment that eliminated the triggers for the onset of symptoms of multiple chemical sensitivity after meticulous interviews with specialists in collaboration with each clinical department. Intravenous sedation using midazolam and propofol under 3 L/min oxygen was a successful approach for minimizing the psychosomatic mechanisms of multiple chemical sensitivity in a patient with dentophobia.</p>

    DOI： 10.24569/jjdsa.51.1_4

    Scopus

    CiNii Research

  • Yamashita Kaoru, Yoshimine Shusei, Uto Akari, Higa Yurina, Shidou Rumi, Hashiguchi Kohei, Shirakawa Yukie, Sugimura Mitsutaka .  A Case in Which Quantitative Test and Feedback of Test Results Helped Decision of Treatment Policy .  Japanese Journal of Orofacial Pain15 ( 1 ) 27 - 30   2023Reviewed

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    Language：Japanese   Publisher：Japanese Society of Orofacial Pain  

    <b>Patients</b>: After a 38-year-old female underwent extraction of tooth 38, which was in close proximity to the mandibular canal, she presented with mental nerve dysesthesia. She was then prescribed vitamin B12. However, her symptoms remained unchanged one month after starting the medication; thus, she requested treatment at a pain clinic. Under the diagnosis of trigeminal neuropathy, she was treated with a stellate ganglion block and acupuncture. After 20 sessions of stellate ganglion block treatment, the pain shifted from dysesthesia to paresthesia; however, there was no significant improvement in subjective symptoms, and the patient was unsure about continuing the treatment. Improvement was observed in the precise tactile function and the electric current perception threshold tests, and these positive results were conveyed to the patient. The patient wanted to continue treatment. After 10 sessions of acupuncture, she was again re-examined. Further improvement was observed in the precise tactile function and the electric current perception threshold tests, and these positive results were conveyed to the patient. As the patient was satisfied with the treatment results and the improvement in her symptoms, she requested treatment cessation.
    <br><b>Discussion</b>: As in the present case, there are cases in which laboratory values improve despite no change in patient complaints about symptoms.
    <br><b>Conclusions</b>: Therefore, for patients, particularly those with orofacial pain, who are hesitant to continue treatment due to a lack of observable change in symptoms, a qualitative examination and provision of feedback on test results showing improvement can be useful in enhancing their decision-making regarding the treatment, thus contributing to the overall improvement in patient satisfaction.

    DOI： 10.11264/jjop.15.27

    CiNii Research

  • Kaoru Yamashita, Akari Uto, Minako Uchino, Rumi Shidou, Toshiro Kibe, Mitsutaka Sugimura .  Sympathetic Nerve Activity During Tooth Extraction in Women Is Related to Dental Anxiety Immediately After Surgery .  Journal of Oral and Maxillofacial Surgery79 ( 11 ) 2268.e1 - 2268.e5   2021.11Reviewed International coauthorship

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MISC

  • 歯科治療時の自律神経活動

    山下 薫, 岐部 俊郎, 内野 美菜子, 宇都 明莉, 吉嶺 秀星, 杉村 光隆

    鹿歯会報, Teethful   170 ( 749 )   13 - 15   2024.2

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    Language：Japanese  

Presentations

  • 宇都 明莉，山下 薫，岐部 俊郎，杉村 光隆   全身麻酔導入時のアニメーションビデオ視聴による周術期ストレス軽減効果の検討  

    第80回NPO法人日本口腔科学会学術集会  2026.4 

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    Event date： 2026.4

    Venue：新潟  

  • 奥 友輔, 橋口 浩平, 宇都 明莉, 祐德 美耀子, 泊 えり, 塚本 真規, 杉村 光隆   障害児の静脈内鎮静法におけるBISモニタリングの4例報告  

    第36回九州歯科麻酔シンポジウム  2026.2 

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    Event date： 2026.2

  • 吉嶺 秀星, 山下 薫, 比嘉 憂理奈, 宇都 明莉, 内野 美菜子, 祐徳 美耀子, 奥 友輔, 大原 由紀子, 杉村 光隆   歯学部学生の一次救命処置実習に関するアンケート調査  

    日本歯科麻酔学会雑誌  2025.10  (一社)日本歯科麻酔学会

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    Event date： 2025.10

    Language：Japanese  

  • 泊 えり, 塚本 真規, 比嘉 憂理奈, 橋口 浩平, 宇都 明莉, 杉村 光隆   術前内服薬による高カリウム血症を認めた患者の全身麻酔経験  

    第53回日本歯科麻酔学会総会  2025.10 

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    Event date： 2025.10

    Venue：鹿児島  

  • 1) 宇都 明莉, 山下 薫, 比嘉 憂理奈, 吉嶺 秀星, 泊 えり, 齊藤 瑞穂, 岐部 俊郎, 杉村 光隆   気管切開術後の Goldenhar 症候群患者 において気管狭窄により挿管チューブ入れ替えに難渋した 1 症例  

    第53回日本歯科麻酔学会総会  2025.10 

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    Event date： 2025.10

    Venue：鹿児島  

  • 奥 友輔, 塚本真規, 吉嶺秀星, 宇都明莉, 杉村光隆   先天性上下顎癒合症に起因した開口制限のため口唇形成術を中止とした症例  

    第35回九州歯科麻酔シンポジウム  2025.2 

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    Event date： 2025.2

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • Akari Uto, Kaoru Yamashita, Shusei Yoshimine, Minako Uchino, Toshiro Kibe, Mitsutaka Sugimura   Autonomic nervous system evaluation of a patient prior to extraction of the impacted mandibular third molar   International conference

    The 72nd Annual Meeting of Japanese Association for Dental, Oral, and Craniofacial Research  2024.11 

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    Event date： 2024.11

    Language：English   Presentation type：Poster presentation  

    Venue：Kagoshima   Country：Japan  

  • Shusei Yoshimine, Kaoru Yamashita, Yurina, Higa, Akari Uto, Mitsutaka Sugimura   The Effect of Voluntary Training with Real-Time Monitoring on the Quality of Cardiopulmonary Resuscitation   International conference

    The 72nd Annual Meeting of Japanese Association for Dental, Oral, and Craniofacial Researc  2024.11 

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    Event date： 2024.11

    Language：English   Presentation type：Poster presentation  

    Venue： Kagoshima   Country：Japan  

  • 吉嶺 秀星, 山下 薫, 岐部 俊郎, 宇都 明莉, 内野 美菜子, 比嘉 憂理奈, 杉村 光隆   術前の東邦メディカルインデックスは自律神経活動や循環動態の予測に有用か?  

    第52回日本歯科麻酔学会  2024.10  (一社)日本歯科麻酔学会

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    Event date： 2024.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：新潟   Country：Japan  

  • 山下 薫, 岐部 俊郎, 内野 美菜子, 宇都 明莉, 吉嶺 秀星, 比嘉 憂理奈, 杉村 光隆   音楽聴取が静脈内鎮静法下抜歯中の循環動態と自律神経活動に与える影響  

    日本歯科麻酔学会雑誌  2024.10  (一社)日本歯科麻酔学会

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    Event date： 2024.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：新潟   Country：Japan  

  • 宇都 明莉, 山下 薫, 岐部 俊郎, 内野 美菜子, 吉嶺 秀星, 奥 友輔, 杉村 光隆   血管迷走神経反射の既往がある患者の抜歯時に自律神経活動モニタリングを行なった症例  

    第52回日本歯科麻酔学会  2024.10  (一社)日本歯科麻酔学会

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    Event date： 2024.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：新潟   Country：Japan  

  • 岐部 俊郎, 山下 薫, 宇都 明莉, 比嘉 憂理奈, 杉村 光隆, 芹澤 慎生, 上栗 裕平, 木村 菜美子, 手塚 征宏, 石畑 清秀   グレン循環患児における口唇形成術・口蓋形成術の周術期管理の経験  

    第6回南九州歯学会  2024.8 

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    Event date： 2024.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：鹿児島   Country：Japan  

  • Shusei Yoshimine, Kaoru Yamashita, Akari Uto, Yurina Higa, Rumi Shidou, Kohei Hashiguchi, Yukie Shirakawa, Mitsutaka Sugimura   A Case in Which Quantitative Test and Feedback of Test Results Helped Decision of Treatment Policy   International conference

    The 21st Scientific Meeting of the Asian Academy of Orofacial Pain and Temporomandibular Disorders  2023.11 

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    Event date： 2023.11

    Language：English   Presentation type：Poster presentation  

    Venue：Fukuoka   Country：Japan  

  • Uto Akari, Yamashita Kaoru, Yoshimine Shusei, Uchino Minako, Kibe Toshiro, Sugimura Mitsutaka   Autonomic nervous system activity during periuperative period of pediatric patients   International conference

    2023.10 

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    Event date： 2023.10

    Language：English   Presentation type：Poster presentation  

    Country：Japan  

  • Yamashita Kaoru, Yoshimine Shusei, Uto Akari, Uchino Minako, Kibe Toshiro, Sugimura Mitsutaka   Effect of local anesthesia at the bone collection site of iliac bone grafting on autonomic nervous system activity and circulatory dynamics in the treatment of patients with alveolar cleft   International conference

    2023.10 

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    Event date： 2023.10

    Language：English   Presentation type：Poster presentation  

    Country：Japan  

  • Yoshimine Shusei, Yasmashita Kaoru, Uto Akari, Uchino Minako, Kibe Toshiro, Sugimura Mitsutaka   A case report of heart rate variability record during the onset of vasovagal reflex   International conference

    2023.10 

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    Event date： 2023.10

    Language：English   Presentation type：Poster presentation  

    Venue：Nagasaki   Country：Japan  

  • 宇都 明莉, 橋口 浩平, 内野 美菜子, 四道 瑠美, 杉村 光隆   22q11.2欠失症候群患者において肺動脈拡張による左主気管支圧迫のため肺胞低換気をきたした１症例  

    第33回九州歯科麻酔シンポジウム  2023.2 

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    Event date： 2023.2

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Japan  

  • 17. Shusei Yoshimine, Kaoru Yamashita, Akari Uto, Yurina Higa, Rumi Shidou, Kohei Hashiguchi, Yukie Shirakawa, Mitsutaka Sugimura   A Case in Which Quantitative Test and Feedback of Test Results Helped Decision of Treatment Policy  

    The 21st Scientific Meeting of the Asian Academy of Orofacial Pain and Temporomandibular Disorders  2023 

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    Event date： 2023

    Venue：Fukuoka   Country：Japan  

  • 宇都 明莉, 山下 薫, 岐部 俊郎, 内野 美菜子, 吉嶺 秀星, 杉村 光隆   小児患者の周術期における自律神経活動・循環動態・心理状態の変化  

    第50回日本歯科麻酔学会  2022.10  (一社)日本歯科麻酔学会

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    Event date： 2022.10 - 2022.12

    Language：Japanese   Presentation type：Poster presentation  

    Venue：東京   Country：Japan  

  • 吉嶺 秀星, 山下 薫, 宇都 明莉, 内野 美菜子, 岐部 俊郎, 杉村 光隆   Modified Dental Anxiety Scaleの取得は歯科治療前の自律神経失調状態の評価に有用である  

    第50回日本歯科麻酔学会  2022.10  (一社)日本歯科麻酔学会

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    Event date： 2022.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • 山下 薫, 岐部 俊郎, 内野 美菜子, 宇都 明莉, 吉嶺 秀星, 四道 瑠美, 杉村 光隆   State Anxiety Inventoryは下顎埋伏抜歯前の患者の自律神経活動予測に有用である  

    第50回日本歯科麻酔学会  2022.10  (一社)日本歯科麻酔学会

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    Event date： 2022.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • 山下 薫, 吉嶺 秀星, 宇都 明莉, 比嘉 憂理奈, 四道 瑠美, 杉村 光隆   星状神経節ブロック時に発症した過換気発作ならびに血管迷走神経反射の回復後に呼吸抑制が持続した症例  

    第27回日本口腔顔面痛学会  2022.10 

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    Event date： 2022.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：千葉   Country：Japan  

  • 大原 由紀子, 大野 幸, 山下 薫, 内野 美菜子, 比嘉 憂理奈, 新納 彩子, 四道 瑠美, 橋口 浩平, 白川 由紀恵, 宇都 明莉, 祐德 美耀子, 吉嶺 秀星, 糀谷 淳, 杉村 光隆   鹿児島大学病院 全身管理⻭科治療部における全身麻酔の実施状況と今後の展望について  

    第4回南九州歯学会  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン開催   Country：Japan  

  • 宇都 明莉, 山下 薫, 内野 美菜子, 岐部 俊郎, 杉村 光隆   下顎埋伏智歯抜歯中の交感神経活動は処置前後の不安の変化と関連する  

    第49回日本歯科麻酔学会  (一社)日本歯科麻酔学会

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    Event date： 2021.10 - 2021.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン開催   Country：Japan  

  • 内野 美菜子, 山下 薫, 岐部 俊郎, 宇都 明莉, 四道 瑠美, 糀谷 淳, 杉村 光隆   静脈内鎮静法が抜歯時の自律神経系と心理状態に与える影響  

    第49回日本歯科麻酔学会  (一社)日本歯科麻酔学会

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    Event date： 2021.10 - 2021.11

    Language：Japanese   Presentation type：Poster presentation  

    Venue：オンライン開催   Country：Japan  

  • 四道 瑠美, 山下 薫, 内野 美菜子, 祐德 美耀子, 白川 由紀恵, 大原 由紀子, 宇都 明莉, 吉嶺 秀星, 杉村 光隆   化学物質過敏症患者の抜歯、歯科治療時の静脈内鎮静法管理経験  

    第3回南九州歯学会  2021.9 

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン開催   Country：Japan  

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Research Projects

  • 全身麻酔導入時のアニメーションビデオ視聴による周術期ストレス軽減効果の検討

    Grant number：25K20482