Updated on 2023/10/25

写真a

 
NISHIMURA Masataka
 
Organization
Research Field in Engineering, Science and Engineering Area Graduate School of Science and Engineering (Engineering) Department of Engineering Information Science and Biomedical Engineering Program Associate Professor
Title
Associate Professor

Research Interests

  • action time

  • 行動実験

  • Auditory Cortex

  • Time

  • Timing Precision

  • Timing

Research Areas

  • Life Science / Neuroscience-general

  • Humanities & Social Sciences / Experimental psychology

  • Life Science / Basic brain sciences

Education

  • Kumamoto University   Graduate School of Medical Sciences   Medical Sciences

    2007.4 - 2011.3

  • Osaka University   Graduate School of Engineering   Electronics

    2005.4 - 2007.3

  • Osaka University   School of Engineering   Electrical engineering

    2001.4 - 2005.3

Research History

  • Kagoshima University   Graduate School of Science and Engineering   Associate Professor

    2023.7

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    Country：Japan

  • Kumamoto University   Department of Sensory and Cognitive Physiology   Assistant Professor

    2011.4 - 2023.6

  • JSPS   Research Fellow (DC1)

    2008.4 - 2011.3

Professional Memberships

  • The Society for Bioacoustics

  • 日本神経科学学会

  • Association for Research in Otolaryngology

 

Papers

  • Masataka Nishimura, Wen-Jie Song .  Region-dependent Millisecond Time-scale Sensitivity in Spectrotemporal Integrations in Guinea Pig Primary Auditory Cortex .  Neuroscience480   229 - 245   2022.1Reviewed International journal

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    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    Spectrotemporal integration is a key function of our auditory system for discriminating spectrotemporally complex sounds, such as words. Response latency in the auditory cortex is known to change with the millisecond time-scale depending on acoustic parameters, such as sound frequency and intensity. The functional significance of the millisecond-range latency difference in the integration remains unclear. Actually, whether the auditory cortex has a sensitivity to the millisecond-range difference has not been systematically examined. Herein, we examined the sensitivity in the primary auditory cortex (A1) using voltage-sensitive dye imaging techniques in guinea pigs. Bandpass noise bursts in two different bands (band-noises), centered at 1 and 16 kHz, respectively, were used for the examination. Onset times of individual band-noises (spectral onset-times) were varied to virtually cancel or magnify the latency difference observed with the band-noises. Conventionally defined nonlinear effects in integration were analyzed at A1 with varying sound intensities (or response latencies) and/or spectral onset-times of the two band-noises. The nonlinear effect measured in the high-frequency region of the A1 linearly changed depending on the millisecond difference of the response onset-times, which were estimated from the spatially-local response latencies and spectral onset-times. In contrast, the low-frequency region of the A1 had no significant sensitivity to the millisecond difference. The millisecond-range latency difference may have functional significance in the spectrotemporal integration with the millisecond time-scale sensitivity at the high-frequency region of A1 but not at the low-frequency region.

    DOI： 10.1016/j.neuroscience.2021.10.030

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  • Masataka Nishimura, Chi Wang, Reika Shu, Wen-Jie Song .  Dynamic changes of timing precision in timed actions during a behavioural task in guinea pigs .  Scientific Reports10 ( 1 ) 20079 - 20079   2020.12Reviewed International journal

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Temporal precision is a determinant of performance in various motor activities. Although the accuracy and precision of timing in activities have been previously measured and quantified, temporal dynamics with flexible precision have not been considered. Here, we examined the temporal dynamics in timed motor activities (timed actions) using a guinea pig model in a behavioural task requiring an animal to control action timing to obtain a water reward. In well-trained animals, momentary variations in timing precision were extracted from the temporal distribution of the timed actions measured over daily 12-h sessions. The resampling of the observed time of action in each session demonstrated significant changes of timing precision within a session. Periods with higher timing precision appeared indiscriminately during the same session, and such periods lasted ~ 20 min on average. We conclude that the timing precision in trained actions is flexible and changes dynamically in guinea pigs. By elucidating the brain mechanisms involved in flexibility and dynamics with an animal model, future studies should establish more effective methods to actively enhance timing precision in our motor activities, such as sports.

    DOI： 10.1038/s41598-020-76953-y

    PubMed

    Other Link： http://www.nature.com/articles/s41598-020-76953-y

  • Masataka Nishimura, Makoto Takemoto, Wen-Jie Song .  Organization of auditory areas in the superior temporal gyrus of marmoset monkeys revealed by real-time optical imaging .  Brain Structure and Function223 ( 4 ) 1599 - 1614   2018.5Organization of auditory areas in the superior temporal gyrus of marmoset monkeys revealed by real-time optical imagingReviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Verlag  

    The prevailing model of the primate auditory cortex proposes a core-belt-parabelt structure. The model proposes three auditory areas in the lateral belt region; however, it may contain more, as this region has been mapped only at a limited spatial resolution. To explore this possibility, we examined the auditory areas in the lateral belt region of the marmoset using a high-resolution optical imaging technique. Based on responses to pure tones, we identified multiple areas in the superior temporal gyrus. The three areas in the core region, the primary area (A1), the rostral area (R), and the rostrotemporal area, were readily identified from their frequency gradients and positions immediately ventral to the lateral sulcus. Three belt areas were identified with frequency gradients and relative positions to A1 and R that were in agreement with previous studies: the caudolateral area, the middle lateral area, and the anterolateral area (AL). Situated between R and AL, however, we identified two additional areas. The first was located caudoventral to R with a frequency gradient in the ventrocaudal direction, which we named the medial anterolateral (MAL) area. The second was a small area with no obvious tonotopy (NT), positioned between the MAL and AL areas. Both the MAL and NT areas responded to a wide range of frequencies (at least 2-24 kHz). Our results suggest that the belt region caudoventral to R is more complex than previously proposed, and we thus call for a refinement of the current primate auditory cortex model.

    DOI： 10.1007/s00429-017-1574-0

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  • Masataka Nishimura, Wen-Jie Song .  Greenwood frequency-position relationship in the primary auditory cortex in guinea pigs .  NEUROIMAGE89   181 - 191   2014.4Greenwood frequency-position relationship in the primary auditory cortex in guinea pigsReviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Although orderly representation of sound frequency over space is a hallmark feature of the primary auditory cortex (A1), the quantitative relationship between sound frequency and cortical position is unclear. We examined this relationship in the guinea pig A1 by presenting a series of stimulus tones with a wide frequency range, and recording the evoked cortical responses using an optical imaging technique with high spatial resolution. We identified the cortical positions of three best-frequency indices for each tone: the onset response position, the peak amplitude position, and the maximum rise rate position of the response. We found a nonlinear log frequency-position relationship for each of the three indices, and the frequency-position relationship was always well described by a Greenwood equation, with correlation coefficients greater than 0.98. The cortical magnification factor, measured in octave/mm, was found to be a function of frequency, i.e. not a constant. Our results are novel in that they demonstrate a quantitative relationship between sound frequency and cortical position in the guinea pig A1, as described by the Greenwood equation. (c) 2013 Elsevier Inc. All rights reserved.

    DOI： 10.1016/j.neuroimage.2013.12.014

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  • Masataka Nishimura, Hiroshi Shirasawa, Hiroyuki Kaizo, Wen-Jie Song .  New field with tonotopic organization in guinea pig auditory cortex .  JOURNAL OF NEUROPHYSIOLOGY97 ( 1 ) 927 - 932   2007.1New field with tonotopic organization in guinea pig auditory cortexReviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER PHYSIOLOGICAL SOC  

    New field with tonotopic organization in guinea pig auditory cortex. J Neurophysiol 97: 927 - 932, 2007. First published October 18, 2006; doi:10.1152/jn. 00689.2006. In guinea pig auditory cortex, two core areas, a primary area (AI) and a dorsocaudal field (DC), and two belt regions ventral to AI and DC (VRB and VCB) with an intermediate zone (T) in between, together with a small field (S) rostral to AI, have been reported in single-electrode studies although field S and zone T have not been observed in imaging studies. Using a high-resolution in vivo optical-imaging system with the voltage-sensitive dye RH-795, we report here the successful imaging of a rostral small field and zone T and a ventral-to-dorsal frequency gradient in zone T. Further, we found that VRB can be subdivided into two areas, a ventrorostral field (VR) with properties similar to those reported for VRB, and a ventrocaudal field (VC) with novel properties. With increasing stimulus tone frequency, activation in VR shifted caudally while activation in VC shifted rostrally. Thus we have newly identified field VC that has mirror-symmetric tonotopy to that of VR.

    DOI： 10.1152/jn.00689.2006

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  • Feifan Chen, Makoto Takemoto, Masataka Nishimura, Ryohei Tomioka, Wen-Jie Song .  Postnatal development of subfields in the core region of the mouse auditory cortex .  Hearing Research400   108138 - 108138   2021.2Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.heares.2020.108138

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  • Masataka Nishimura, Hiroyuki Sawatari, Makoto Takemoto, Wen-Jie Song .  Identification of the somatosensory parietal ventral area and overlap of the somatosensory and auditory cortices in mice .  NEUROSCIENCE RESEARCH99   55 - 61   2015.10Identification of the somatosensory parietal ventral area and overlap of the somatosensory and auditory cortices in miceReviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

    This study aimed to identify the parietal ventral (PV) area of the somatosensory cortex in mice and to determine whether auditory cortex and somatosensory cortex overlap. Using high resolution, voltage-sensitive dye-based imaging, we identified the PV area, which exhibited strong responses to stimulation of distal body parts but weak responses to stimulation of proximal and facial body parts. We further demonstrated a substantial overlap between the auditory and non-primary somatosensory areas, including the PV area. We found statistically significant non-additive integration of auditory and somatosensory inputs in the overlapping region, suggesting convergence of the two input streams at the cellular level. We have thus delineated the PV area in mice for the first time, and have shown that it is a likely site for the integration of auditory and somatic inputs. (C) 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

    DOI： 10.1016/j.neures.2015.06.001

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  • Makoto Takemoto, Kayoko Hasegawa, Masataka Nishimura, Wen-Jie Song .  The insular auditory field receives input from the lemniscal subdivision of the auditory thalamus in mice .  JOURNAL OF COMPARATIVE NEUROLOGY522 ( 6 ) 1373 - 1389   2014.4The insular auditory field receives input from the lemniscal subdivision of the auditory thalamus in miceReviewed

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

    The insular cortex plays important roles in vocal communication, but the origin of auditory input to the insular cortex has not been fully clarified. Here we studied the auditory thalamic input to the insular cortex using mice as a model system. An insular auditory field (IAF) has recently been identified in mice. By using retrograde neuronal tracing, we identified auditory thalamic neurons projecting to the IAF, primary auditory cortex (AI), and anterior auditory field (AAF). After mapping the IAF, AAF, and AI by using optical imaging, we injected a distinct fluorescent tracer into each of the three fields at frequency-matched locations. Tracer injection into the IAF resulted in retrogradely labeled cells localized ventromedially in the lemniscal division, i.e., the ventral subdivision of the medial geniculate body (MGv). Cells retrogradely labeled by injections into the AAF were primarily found in the medial half of the MGv, whereas those from AI injections were located in the lateral half, although some of these two subsets were intermingled within the MGv. Interestingly, retrogradely labeled cells projecting to the IAF showed virtually no overlap with those projecting to the AAF or the AI. Dual tracer injections into two sites responding to low- and high-frequency tones within each of the three auditory fields demonstrated topographic organizations in all three thalamocortical projections. These results indicate that the IAF receives thalamic input from the MGv in a topographic manner, and that the MGv-IAF projection is parallel to the MGv-AAF and MGv-AI projections. J. Comp. Neurol. 522:1373-1389, 2014. (c) 2013 Wiley Periodicals, Inc.

    DOI： 10.1002/cne.23491

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  • Wen Jie Song, Masataka Nishimura, Kazuya Saitoh .  Auditory cortex in guinea pigs: Subfield organization and functional domains .  Auditory Cortex: Anatomy, Functions and Disorders   75 - 84   2012.10

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    The guinea pig produces a variety of vocalizations, providing a suitable mammalian model for auditory research. The organization of the auditory cortex in guinea pigs, however, remains to be elucidated. We have examined this issue over the past several years using in vivo optical imaging techniques. Our results indicate that guinea pig auditory cortex is comprised by a core area, consisting of the primary area (AI) and a field dorsocaudal to the AI. A number of belt regions have been found around the core, which exhibit different functional characteristics. By examining the spatiotemporal response patterns in the AI to tone stimulation and electrical stimulation, we show that an isofrequency strip in the AI appears to operate as a functional domain. Evidence from spontaneous activity in the AI also supports this notion. The functional domain of an isofrequency strip has implications for the development of auditory prostheses involving cortical stimulation. © 2012 by Nova Science Publishers, Inc. All rights reserved.

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  • Masataka Nishimura, Wen-Jie Song .  Temporal Sequence of Visuo-Auditory Interaction in Multiple Areas of the Guinea Pig Visual Cortex .  PLOS ONE7 ( 9 ) e46339   2012.9Temporal Sequence of Visuo-Auditory Interaction in Multiple Areas of the Guinea Pig Visual CortexReviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：PUBLIC LIBRARY SCIENCE  

    Recent studies in humans and monkeys have reported that acoustic stimulation influences visual responses in the primary visual cortex (V1). Such influences can be generated in V1, either by direct auditory projections or by feedback projections from extrastriate cortices. To test these hypotheses, cortical activities were recorded using optical imaging at a high spatiotemporal resolution from multiple areas of the guinea pig visual cortex, to visual and/or acoustic stimulations. Visuo-auditory interactions were evaluated according to differences between responses evoked by combined auditory and visual stimulation, and the sum of responses evoked by separate visual and auditory stimulations. Simultaneous presentation of visual and acoustic stimulations resulted in significant interactions in V1, which occurred earlier than in other visual areas. When acoustic stimulation preceded visual stimulation, significant visuo-auditory interactions were detected only in V1. These results suggest that V1 is a cortical origin of visuo-auditory interaction.

    DOI： 10.1371/journal.pone.0046339

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  • Mei-Hong Lu, Makoto Takemoto, Ken Watanabe, Huan Luo, Masataka Nishimura, Masato Yano, Hidekazu Tomimoto, Toshiro Okazaki, Yuichi Oike, Wen-Jie Song .  Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice .  JOURNAL OF PHYSIOLOGY-LONDON590 ( 16 ) 4029 - 4044   2012.8Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in miceReviewed

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

    Sphingomyelin (SM) is a sphingolipid reported to function as a structural component of plasma membranes and to participate in signal transduction. The role of SM metabolism in the process of hearing remains controversial. Here, we examined the role of SM synthase (SMS), which is subcategorized into the family members SMS1 and SMS2, in auditory function. Measurements of auditory brainstem response (ABR) revealed hearing impairment in SMS1(-/-) mice in a low frequency range (4-16 kHz). As a possiblemechanism of this impairment, we found that the stria vascularis (SV) in these mice exhibited atrophy and disorganized marginal cells. Consequently, SMS1(-/-) mice exhibited significantly smaller endocochlear potentials (EPs). As a possible mechanism for EP reduction, we found altered expression patterns and a reduced level of KCNQ1 channel protein in the SV of SMS1(-/-) mice. These mice also exhibited reduced levels of distortion product otoacoustic emissions. Quantitative comparison of the SV atrophy, KCNQ1 expression, and outer hair cell density at the cochlear apical and basal turns revealed no location dependence, but more macrophage invasion into the SV was observed in the apical region than the basal region, suggesting a role of cochlear location-dependent oxidative stress in producing the frequency dependence of hearing loss in SMS1(-/-) mice. Elevated ABR thresholds, decreased EPs, and abnormal KCNQ1 expression patterns in SMS1(-/-) mice were all found to be progressive with age. Mice lacking SMS2, however, exhibited neither detectable hearing loss nor changes in their EPs. Taken together, our results suggest that hearing impairments occur in SMS1(-/-) but not SMS2(-/-) mice. Defects in the SV with subsequent reductions in EPs together with hair cell dysfunction may account, at least partially, for hearing impairments in SMS1(-/-) mice.

    DOI： 10.1113/jphysiol.2012.235846

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  • Hiroyuki Sawatari, Yoshihide Tanaka, Makoto Takemoto, Masataka Nishimura, Kayoko Hasegawa, Kazuya Saitoh, Wen-Jie Song .  Identification and characterization of an insular auditory field in mice .  EUROPEAN JOURNAL OF NEUROSCIENCE34 ( 12 ) 1944 - 1952   2011.12Identification and characterization of an insular auditory field in miceReviewed

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

    We used voltage-sensitive-dye-based imaging techniques to identify and characterize the insular auditory field (IAF) in mice. Previous research has identified five auditory fields in the mouse auditory cortex, including the primary field and the anterior auditory field. This study confirmed the existence of the primary field and anterior auditory field by examining the tonotopy in each field. Further, we identified a previously unreported IAF located rostral to known auditory fields. Pure tone evoked responses in the IAF exhibited the shortest latency among all auditory fields at lower frequencies. A rostroventral to dorsocaudal frequency gradient was consistently observed in the IAF in all animals examined. Neither the response amplitude nor the response duration changed with frequency in the IAF, but the area of activation exhibited a significant increase with decreasing tone frequency. Taken together, the current results indicate the existence of an IAF in mice, with characteristics suggesting a role in the rapid detection of lower frequency components of incoming sound.

    DOI： 10.1111/j.1460-9568.2011.07926.x

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  • Kazuya Saitoh, Shinji Inagaki, Masataka Nishimura, Hideo Kawaguchi, Wen-Jie Song .  Spontaneous activity resembling tone-evoked activity in the primary auditory cortex of guinea pigs .  NEUROSCIENCE RESEARCH68 ( 2 ) 107 - 113   2010.10Spontaneous activity resembling tone-evoked activity in the primary auditory cortex of guinea pigsReviewed

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

    In the primary auditory cortex (AI), a pure tone evokes propagating activity along a strip of the cortex. We have previously shown that focal activation of AI triggers autonomously propagating activity that resembles tone-evoked activity (Song et al., 2006). Because a focal spontaneous activity is expected to trigger similar activity propagation, spontaneous activity resembling tone-evoked activity may exist in AI. Here we tested this possibility by optical imaging of AI in guinea pigs. After obtaining tone-evoked activities, we made long-duration optical recordings (9-40 s) and isolated spontaneous activities from respiration and heartbeat noises using independent component analyses. Spontaneous activities were found all over AI, in all animals examined. Of all spontaneous events, 33.6% showed significant correlation in spatio-temporal pattern with tone-evoked activities. Simulation using a model that captures the temporal feature of spontaneous response in single channels but sets no constraint among channels, generated no spontaneous events that resembled tone-evoked activations. These results show the existence of spontaneous events similar in spatio-temporal pattern to tone-evoked activations in AI. Such spontaneous events are likely a manifestation of cortical structures that govern the pattern of distributed activation in AI. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

    DOI： 10.1016/j.neures.2010.06.009

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  • WJ Song, H Kawaguchi, S Totoki, Y Inoue, T Katura, S Maeda, S Inagaki, H Shirasawa, M Nishimura .  Cortical intrinsic circuits can support activity propagation through an isofrequency strip of the guinea pig primary auditory cortex .  CEREBRAL CORTEX16 ( 5 ) 718 - 729   2006.5Cortical intrinsic circuits can support activity propagation through an isofrequency strip of the guinea pig primary auditory cortexReviewed

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：OXFORD UNIV PRESS INC  

    A pure tone evokes propagating activities in a strip of the primary auditory cortex (AI), an isofrequency strip (IS). A fundamental issue concerns the roles that thalamocortical input and intracortical connectivity play in generating the activities. Here we addressed this issue in guinea pigs using in vivo and in vitro real-time optical imaging techniques. As reported previously, tone-evoked activity propagated dorsoventrally along a strip (an IS) in AI. We found that an electrical pulse applied focally within the strip, triggered activity propagation with a spatiotemporal pattern highly similar to tone-evoked activation. The propagation velocity of electrically evoked activity was significantly slower than that of tone-evoked activity, but was comparable to the velocity of lateral activity propagation in cortical slices, suggesting that the electrically evoked activity propagation in vivo is mediated by intracortical circuits. To test this notion, we lesioned the auditory thalamus chemically; in such animals, electrically evoked activity in AI was not affected, although tone-evoked activity was abolished. Further, in slices of the AI, the extent of electrically evoked activity propagation in layer II/III was significantly larger in coronal slices than in horizontal slices. Together, our results suggest that intracortical connectivity in AI enables a focally evoked activity to propagate throughout an IS.

    DOI： 10.1093/cercor/bhj018

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  • M Nishimura, H Shirasawa, WJ Song .  A light-emitting diode light source for imaging of neural activities with voltage-sensitive dyes .  NEUROSCIENCE RESEARCH54 ( 3 ) 230 - 234   2006.3A light-emitting diode light source for imaging of neural activities with voltage-sensitive dyesReviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

    We tested the possibility of using a high-power monochromatic InGaN light-emitting diode (LED) as an excitation light source for real-time optical imaging using the voltage-sensitive dye RH-795. Driven with a custom-designed, non-feedback-controlled constant-current circuit, the LED generated stable light with rapid on/off. The LED was comparable with commonly used halogen lamps in exciting RH-795. Acoustically evoked responses in the auditory cortex recorded with the two light sources were highly similar. Our results thus suggest that a high-power LED can be successfully used as an excitation light source for voltage-sensitive dyes, without the need of optical filters and shutters. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

    DOI： 10.1016/j.neures.2005.12.002

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Books

  • 生き物と音の事典

    生物音響学会, 西村ら（ Role： Contributor ,  音の減衰と吸音, 音の干渉, 音の回折と屈折, 音声による話者認識）

    朝倉書店  2019.10 

  • そのまま使えるPHPサンプル100選

    （ Role： Joint author）

    技術評論社  2002.10  （ ISBN:4774115762 ）

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    Total pages：viii, 263p   Language：Japanese

    CiNii Books

MISC

  • Author Correction: Dynamic changes of timing precision in timed actions during a behavioural task in guinea pigs (Scientific Reports, (2020), 10, 1, (20079), 10.1038/s41598-020-76953-y)

    Nishimura M., Wang C., Shu R., Song W.J.

    Scientific Reports   11 ( 1 )   15636   2021.12

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    Language：Japanese   Publisher：Scientific Reports  

    The original version of this Article contained errors. In Figure 2c, the y-axis label “Abandoned ratio (%)” was incorrectly given as “Passed ratio (%)”. Additionally, in the symbol legend, the unfilled circled indicating “abandoned ratio” was incorrectly given as “passed ratio”. Furthermore, in Figure 4a, the x and y-axis labels were incorrectly swapped. Lastly, in Figure 5a, the label indicating “Original” data was incorrectly given as “Real.” In Figure 5f, the x-axis label “Original” was incorrectly given as “Real.” The original Figures 2, 4 and 5 and their accompanying legends appear below. The original Article has been corrected. (Figure presented.).

    DOI： 10.1038/s41598-021-94593-8

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  • Novel areas in the lateral belt region of marmoset auditory cortex

    47 ( 4 )   209 - 212   2017.6

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    Language：Japanese  

    CiNii Books

  • Earlier Response to Higher Frequency Tones Facilitates Representation of High Frequency Tones in Guinea Pig Primary Auditory Cortex

    44 ( 8 )   513 - 515   2014.11

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    Language：Japanese  

    CiNii Books

  • Neural circuits of the insular auditory field in mice : Anatomical studies

    43 ( 3 )   157 - 159   2013.5

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    Language：Japanese  

    CiNii Books

  • Auditory response and influences in the guinea pig primary visual cortex

    Masataka Nishimura, Wen-Jie Song

    NEUROSCIENCE RESEARCH   71   E151 - E151   2011

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ELSEVIER IRELAND LTD  

    DOI： 10.1016/j.neures.2011.07.652

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  • Mapping of the Auditory and Somatosensory Cortical Areas in Mice : A Voltage-sensitive-dye-based Imaging Study

    40 ( 9 )   773 - 776   2010.11

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    Language：Japanese  

    CiNii Books

  • Formulation for reduction of noise in fractional signal estimation in imaging studies

    Masataka Nishimura, Wen-Jie Song

    NEUROSCIENCE RESEARCH   68   E441 - E441   2010

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ELSEVIER IRELAND LTD  

    DOI： 10.1016/j.neures.2010.07.1956

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  • Optical imaging-based parcellation of mouse auditory cortex

    Hiroyuki Sawatari, Yoshihide Tanaka, Masataka Nishimura, Wen-Jie Song

    NEUROSCIENCE RESEARCH   68   E271 - E272   2010

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ELSEVIER IRELAND LTD  

    DOI： 10.1016/j.neures.2010.07.1208

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  • Frequency discrimination using optical signal from the primary auditory cortex of guinea pig

    齋藤 和也, 西村 方孝, 宋 文杰

    聴覚研究会資料   39 ( 7 )   489 - 493   2009.11

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    Language：Japanese   Publisher：日本音響学会聴覚研究委員会  

    CiNii Books

  • AUDITORY BRAINSTEM RESPONSE IN MICE

    Meihong Lu, Masataka Nishimura, Kazuya Saitoh, Wen-Jie Song

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   201 - 201   2009

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：SPRINGER TOKYO  

    Web of Science

  • Mutual information between acoustic stimuli and optical signals in the primary auditory cortex

    Kazuya Saitoh, Masataka Nishimura, Wen-Jie Song

    NEUROSCIENCE RESEARCH   65   S208 - S208   2009

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ELSEVIER IRELAND LTD  

    DOI： 10.1016/j.neures.2009.09.1145

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  • FREQUENCY- AND LEVEL-DEPENDENT DETECTABLE CHANGE OF AUDITORY RESPONSE PATTERN IN THE CORTEX

    Kazuya Saitoh, Masataka Nishimura, Wen-Jie Song

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   427 - 427   2009

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：SPRINGER TOKYO  

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  • Optical measurements of frequency discrimination in the primary auditory cortex

    齋藤 和也, 西村 方孝, 宋 文杰

    聴覚研究会資料   38 ( 7 )   727 - 731   2008.11

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    Language：Japanese   Publisher：日本音響学会聴覚研究委員会  

    CiNii Books

  • Frequency-dependence of response latencies in subfields of guinea pig auditory cortex

    Masataka Nishimura, Kazuya Saitoh, Wen-Jie Song

    NEUROSCIENCE RESEARCH   61   S247 - S247   2008

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ELSEVIER IRELAND LTD  

    Web of Science

  • Variability and stability of tone-evoked responses in the primary auditory cortex of guinea pigs

    Kazuya Saitoh, Masataka Nishimura, Wen-Jie Song

    NEUROSCIENCE RESEARCH   61   S247 - S247   2008

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ELSEVIER IRELAND LTD  

    Web of Science

  • Parcellation of guinea pig auditory cortex: observation with real-time imaging

    37 ( 10 )   823 - 827   2007.12

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    Language：Japanese  

    CiNii Books

  • Spatial representation of tone frequency in guinea pig auditory cortex

    37 ( 4 )   329 - 334   2007.5

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    Language：Japanese  

    CiNii Books

  • Characterization of belt regions caudal to the dorsocaudal field in guinea pig auditory cortex

    Masataka Nishimura, Wen-Jie Song

    NEUROSCIENCE RESEARCH   58   S156 - S156   2007

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ELSEVIER IRELAND LTD  

    Web of Science

  • A redefinition of the ventrorostral belt region of guinea pig auditory cortex

    36 ( 3 )   309 - 313   2006.5

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    Language：Japanese  

    CiNii Books

  • A newly-identified field in guinea pig auditory cortex

    Masataka Nishimura, Hiroyuki Kaizo, Wen-Jie Song

    NEUROSCIENCE RESEARCH   55   S153 - S153   2006

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ELSEVIER IRELAND LTD  

    Web of Science

  • Quantitative Examination of Borders between Subfields of Auditory Cortex in the Guinea Pigs

    SHIRASAWA Hiroshi, NISHIMURA Masataka, SONG Wen-Jie

    IEICE technical report   105 ( 335 )   1 - 4   2005.10

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    Language：Japanese   Publisher：The Institute of Electronics, Information and Communication Engineers  

    It has been reported that the auditory cortex is consisted of a core region, directly innervated from the thalamus, and surrounding belt regions. However, the border between these regions was not clearly defined. Here we quantitatively examined the border between the primary cortex (AI) and the ventrorostral belt region (VRB) from response-patterns or feature quantities such as latency, using high resolution optical imaging. We found that the timing or the strength of responses, as well as the degree of overlap between responses to different sound frequencies, defined a similar border between AI and VRB.

    CiNii Books

  • Adoption of light-emitting diode as excitation light source for in vivo optical imaging with voltage sensitive dyes

    NISHIMURA Masataka, SHIRASAWA Hiroshi, SONG Wen-Jie

    IEICE technical report   105 ( 335 )   5 - 8   2005.10

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    Language：Japanese   Publisher：The Institute of Electronics, Information and Communication Engineers  

    We have designed a high power monochromatic light source for optical recording by using a high power light-emitting diode(LED). LED has the characteristics of fast response and narrow band spectrum, therefore a mechanical shutter and an optical band-pass filter are not required when a LED is used as an excitation light source, unlike traditional tungsten halogen lamps. Results of optical imaging using the voltage-sensitive dye RH-795 showed that tungsten halogen lamp can be replaced with power LED as excitation light source.

    CiNii Books

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Presentations

  • Masataka Nishimura, Wen-Jie Song   Adaptive conditioning parameters in the behavioural task to reliably decode animal’s acoustic perception  

    ASJ-H  2019.6 

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • 西村方孝, 白沢寛司, SONG Wen‐Jie   Adoption of light-emitting diode as excitation light source for in vivo optical imaging with voltage sensitive dyes  

    電子情報通信学会技術研究報告  2005.10 

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    Language：Japanese  

  • SONG Wen‐Jie, 斉藤和也, 竹本誠, 西村方孝   聴覚皮質一次野の周波数弁別反応  

    電気学会電子・情報・システム部門大会講演論文集(CD-ROM)  2010 

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    Language：Japanese  

  • 西村方孝, SONG Wen‐Jie   皮質応答の動的性質と周波数補償  

    日本音響学会聴覚研究会資料  2014.11 

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    Language：Japanese  

  • 王馳, 西村方孝, 白見優大, 宋文杰   時間精度が要求される動作における脳内時間生成機構の解明を目指す動物モデルの確立  

    第68回 西日本生理学会  2017.10 

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • Chi Wang, Yuta Shiromi, Wen-Jie Song, Masataka Nishimura   Serveral-minute lasting extreme precision observed in a sub-second timing production task in guinea pigs  

    Neuroscience 2018  2018.7 

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    Language：English   Presentation type：Poster presentation  

  • 竹本誠, 長谷川佳代子, 西村方孝, SONG Wen‐Jie   島皮質聴覚野を中心とした神経回路―解剖学的解析―  

    日本音響学会聴覚研究会資料  2013.5 

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    Language：Japanese  

  • 宋文杰, 西村方孝   大脳皮質一次聴覚野において場所と周波数はGreenwood関係に従う  

    日本生理学雑誌  2014 

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    Language：Japanese  

  • Masataka Nishimura, Makoto Takemoto, Wen-Jie Song   Optical imaging-based parcellation of the marmoset auditory cortex  

    Neuroscience2016  2016.7 

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    Language：English   Presentation type：Poster presentation  

  • Identification of marmoset auditory subfields in superior temporal cortex  

    2017.7 

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    Language：English   Presentation type：Poster presentation  

  • 白沢寛司, 西村方孝, SONG Wen‐Jie   Quantitative Examination of Borders between Subfields of Auditory Cortex in the Guinea Pigs  

    電子情報通信学会技術研究報告  2005.10 

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    Language：Japanese  

  • 澤渡浩之, 田中良秀, 西村方孝, 宋文杰   マウス聴覚皮質及び体性感覚皮質の大規模イメージング  

    日本生理学雑誌  2011.1 

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    Language：Japanese  

  • 田中良秀, 西村方孝, 長谷川佳代子, 斎藤和也, 宋文杰   マウス大脳皮質聴覚野の領野構成  

    日本生理学雑誌  2010.2 

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  • 竹本誠, 呂美紅, 渡辺研, 矢野正人, 西村方孝, 冨本秀和, 岡崎俊郎, 尾池雄一, 宋文杰   スフィンゴミエリン合成酵素遺伝子欠損による難聴とその内耳機構に関する研究  

    日本生理学雑誌  2012.5 

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    Language：Japanese  

  • Masataka Nishimura, Yuta Shiromi, Wen-Jie Song   Mating-Related Interactive Vocal Communication with Sub-centisecond Precision in Guinea Pigs  

    ARO 2016 MidWinter Meeting  2016.2 

  • Masataka Nishimura, Wen-Jie Song   Impacts of Millisecond-order Onset Timing Difference of High Frequency Component in Spectrally Complex Sounds on Cortrical Activity and Sensation   International conference

    ARO 2017 MidWinter Meeting  2017.2 

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    Language：English   Presentation type：Poster presentation  

  • Chi Wang, Masataka Nishimura, Wen-Jie Song   Guinea pigs can learn to change behavioral response latency to report their sensation difference to three different sounds   International conference

    The 3rd Annual Meeting of the Society for Bioacoustics  2016.12 

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    Language：English   Presentation type：Poster presentation  

  • Masataka Nishimura, Wen-Jie Song   Beneficial Effect of Frequency-dependent Response Latency on Frequency Integration in Guinea Pig Primary Auditory Cortex   International conference

    ARO 2015 MidWinter Meeting  2015.2 

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    Language：English   Presentation type：Poster presentation  

  • Masataka Nishimura, Chi Wang, Yuta Shiromi, Wen-Jie Song   A Newly-Developed Timing Production Task For Guinea Pigs To Mimic Decodable Quick Actions of Human   International conference

    ARO 42nd Annual MidWinter Meeting  2019.2 

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    Language：English   Presentation type：Poster presentation  

  • Masataka Nishimura, Wen-Jie Song   A binaural compensatory mechanism in the auditory system: enhanced cortical response to a sound to the ipsilateral ear in a stream of binaural sounds   International conference

    The 2nd Annual Meeting of the Society for Bioacoustics  2015.12 

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    Language：English   Presentation type：Poster presentation  

  • Masataka Nishimura, Wen-Jie Song   Quantal timing generation in internal estimation of prospective sub-second time for actions in guinea pigs  

    NEURO2022  2022.7 

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    Language：English   Presentation type：Poster presentation  

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Works

  • Variable-Speed Audio Player

    2021.5

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    Work type：Software  

    オーディオデバイスの潜在的性能を最⼤限に引き出して、原⾳再現性を可能な限り⾼め、オーディオデータ（WAVE ファイル形式）をより忠実に再⽣できます。

    再生速度を連続的に変化させることができます。

    ⾳のキーを上下させることができます。（再⽣時間、⾳の⻑さも変わります）

  • Sound Sweeper WASAPI

    Masataka Nishimura

    2021.5

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    Work type：Software  

Research Projects

  • 超音波伝送を用いて視覚障害者に音声で危険情報を知らせる装置の開発

    2022.10 - 2024.3

    国立研究開発法人科学技術振興機構  研究成果展開事業（研究成果最適展開支援プログラム（A-STEP））  A-STEPトライアウト

    西村 方孝, 中村 佳敬

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    Authorship：Principal investigator 

  • 運動パフォーマンス決定因子である運動時間精度へのカフェインの影響の定量的検討

    Grant number：22K11605  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

  • 広帯域音声が有する豊かな質感の音声内起源およびその知覚機構の解明

    Grant number：17K13964  2017.4 - 2020.3

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    西村 方孝

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    本年度は、実験動物の音声に対する認知の確からしさを動物の行動から定量的に評価するための実験プロトコル及び解析手法の確立を目指して動物実験を行った。実験にはモルモットを用い、動物の行動を引き起こすための音声としては、ヒトに対する心理実験で用いた音声の帯域とほぼ同等の帯域（500 Hz±0.25オクターブ、13.5 kHz±0.25オクターブ）の帯域雑音を用いた。既存の古典的条件付やオペラント条件付では、動物の認知の確からしさを評価しても高い確からしさが得られないことが見積もられたことから、本研究では、適応的条件付パラメータという考え方を新しく導入し、動物が提示された音声に対して正確な時間に行動させることを目標に実験及びプロトコルの改善を進めていったところ、動物の行動から算出される認知の不確かさが5%未満であることを数学的に保証する手法を確立した。
    動物は言葉で実験者に認知の結果を伝えることが困難なので、動物の認知は、その行動からしか客観的に評価することができない。脳で行われている音声周波数統合と、その統合によって引き起こされた認知を行動から評価することは、その仕組みを解明する上では欠かせないものであると言える。今年度の研究によって、実験動物の音声に対する認知の確からしさを客観的かつ定量的に評価する実験手法が確立されたことは、次年度の研究のみならず、動物モデルを用いた認知に関する実験全体への貢献につながると考えられる。

  • 視床下部摂食中枢神経回路の補償機構と臨界期を探る

    Grant number：16K08470  2016.4 - 2020.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    江角 重行, 浜崎 禎, 西村 方孝

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    我々は視床下部摂食中枢神経回路の補償機構や臨界期の分子機構を明らかし、その破綻によって摂食障害が生じるメカニズムを解明することを目的として研究を進めている。これまでの報告で大脳皮質の発達過程における臨界期可塑性にはGABAニューロンが重要である(Hensch,2005, Nature Rev Neurosci.) (Katagiri H et al,2007, Neuron)ことがわかっている。そこで、我々は視床下部で見られる神経回路の補償機構や臨界期においても、GABAニューロンが関係していると考え、平成30年度は、視床下部摂食中枢の補償機構を制御する神経回路におけるGABAニューロンの機能を探るため遺伝子改変マウスを用いて解析を行った。具体的には、GABAニューロンでGABAを放出するために必須であるvesicular GABA transporter (VGAT)を floxed-VGAT マウスとNkx2-1-Cre; floxed-VGATマウスを組み合わせ、大脳皮質と視床下部のみ特異的にGABAニューロンのGABA分泌を停止させて解析を行った。その結果、VGAT欠損マウスで認められる口蓋裂や臍帯ヘルニアは生じないにも関わらず、生後2日目には全て死亡することが明らかになった。生後間もない時期には、全てのマウスの胃にミルクが確認できることから、ホモマウスの致死の原因は視床下部のGABAニューロンの機能不全によると考られる。そこで、その原因を探るため生後0日目のNkx2-1-Cre; floxed-VGAT ホモ/ヘテロマウスの視床下部のRNAを抽出し、次世代シークエンサーを用いて変動する遺伝子を解析した。その結果、"neuron development", "axon guidance"などに関わる分子群に変動が認められた。

  • Establishment of an animal model of timing production for speech and investigation of brain locations involved in the timing control

    Grant number：15K16566  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Nishimura Masataka

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    Appropriate timing and enough precision of speech production is essential for our vocal communication to represent our intention. In the present research, we aimed to establish an animal model which produces appropriate timing with enough precision to investigate the brain mechanism of timing production for quick actions such as speech, by using a conventional laboratory animal, guinea pig. We succeeded to condition guinea pigs to discriminate at most three timing cues and to switch timing of response for each cue. Guinea pigs produced timing with ±5% error (at minimum) for 0.3 sec timing, which is comparable to real vocal communication of guinea pig. Taken together, the animal model was successfully established and now we have a basis to study how brain produces timing to represent our intention with invasive techniques.

  • 新規に発見した聴覚皮質腹尾側領野の機能に関する研究

    Grant number：08J03900  2008 - 2010

    日本学術振興会  科学研究費助成事業 特別研究員奨励費  特別研究員奨励費

    西村 方孝

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    Grant amount：\1800000 （ Direct Cost: \1800000 ）

    一昨年度に本研究で作成した波形合成ソフトウェアや音響システムでは、音響システムの逆伝達関数の推定精度に問題があり、周波数変調(FM)音を任意の音圧で合成することが困難であった。しかし振幅変調(AM)音のみでは当該領野の特徴付けが不十分であることが明らかになったので、FM音を精度よく音響システムから出力することが必要となった。より高精度に音響システムの逆伝達関数を推定するために、フーリエ信号から人工的に合成された白色雑音を用いて1,000回程度の加算平均により伝達関数を推定した。これにより高精度にAM音そしてFM音が合成できるようになったので、それらの音を用いて一次聴覚野(AI)、背尾側領野(DC)、腹吻側領野(VR)、腹尾側領野(VC)の活動を光計測法により計測したが、FM音に関しては、主に始まりの周波数の音に対する応答が支配的で、顕著な応答特性の差は見られなかった。AM音に関しては、AI、DC、そしてVRの吻側部で高い追従性が見られたものの、VCでは高い追従性が見られなかった。追従性はWelch法により評価した。VCの応答性をDC周辺のベルト領域内の領野群と比較するため、短い純音刺激を用いてそれら領野の同定を行った結果、応答の周波数局在性(トノトピー)を有しない背尾側ベルト(DCB)と腹尾側ベルト(VCB)、そしてそれら領野の中間に位置し、DCと同じ向きのトノトピー勾配を有する後側領野(P)が実験した全ての動物で見られた。DCB、VCBにおいてはAM音に対しての追従性は低く、PにおいてはAI、DCと並ぶ追従性を有していることが明らかになった。
    そのPの追従性はVCのそれよりも高かった。以上の結果を踏まえると、音の時間的情報の一つである包絡線情報の抽出にはコア領域内のAI、DC、そしてベルト領域内のPが積極的に関与し、VCは非時間的情報の抽出に関与している可能性が示唆された。

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Teaching Experience

  • Electromagnetics

    2023.10
    Institution：Kagoshima University

  • Fundamentals of data science and its mathematics

    2023.10
    Institution：Kagoshima University

  • Information Science and Biomedical Engineering Laboratory II

    2023.10
    Institution：Kagoshima University

  • 英語

    Institution：熊本大学

  • 脳科学

    Institution：熊本大学

  • 生理学

    Institution：熊本大学

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