Updated on 2023/11/20

写真a

 
NAKANISHI Kazuki
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine Assistant Professor
Title
Assistant Professor

Degree

  • 博士(保健学) ( 2021.3   鹿児島大学 )

  • 修士(保健学) ( 2018.3   鹿児島大学 )

Research Interests

  • 認知機能

  • 運動

  • 理学療法

  • リハビリテーション

Research Areas

  • Life Science / Cognitive and brain science

  • Life Science / Rehabilitation science

Research History

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine   Assistant Professor

    2022.6

  • Kagoshima University   Special researcher of the Japan Society for the Promotion of Science

    2020.4 - 2022.3

Professional Memberships

  • 日本神経科学学会

    2018.7

  • コ・メディカル形態機能学会

    2018

  • 日本理学療法士協会

    2016.4

Committee Memberships

  • 日本理学療法士協会   理学療法学査読委員  

    2022.10   

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    Committee type:Academic society

Qualification acquired

  • Physiotherapist

 

Papers

  • Nakanishi K, Norimatsu K, Tani A, Matsuoka T, Matsuzaki R, Kakimoto S, Nojima N, Tachibe Y, Kato Y, Inadome M, Kitazato R, Otsuka S, Takada S, Sumizono M, Sakakima H .  Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8. .  Neuroscience letters808   137297   2023.5Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neulet.2023.137297

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  • Nakanishi K., Sakakima H., Norimatsu K., Otsuka S., Takada S., Tani A., Kikuchi K. .  Effect of low-intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer's disease .  Experimental Neurology337   113590   2021.3Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Doctoral thesis  

    DOI: 10.1016/j.expneurol.2020.113590

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  • Kikuchi K, Otsuka S, Takada S, Nakanishi K, Setoyama K, Sakakima H, Tanaka E, Maruyama I .  1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5'-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway. .  Aging15   2023.111,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5'-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/aging.205228

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  • Norimatsu K, Nakanishi K, Ijuin T, Otsuka S, Takada S, Tani A, Matsuzaki R, Matsuoka T, Sakakima H .  Effects of low-intensity exercise on spontaneously developed knee osteoarthritis in male senescence-accelerated mouse prone 8. .  Arthritis research & therapy25 ( 1 ) 168   2023.9Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Arthritis Research and Therapy  

    Background: Osteoarthritis (OA) is a degenerative joint disease associated with aging, which often leads to joint stiffness and disability. Exercise is one of the most important non-pharmacological treatments and is prescribed as an indispensable treatment for OA. However, whether physical exercise is beneficial for preventing the progression of OA symptoms with age is poorly understood. We investigated the effects of exercise on spontaneously developed knee OA using male senescence-accelerated mouse prone 8 (SAMP8). Methods: To examine age-related changes in the knee joints of SAMP8, knee articular cartilage changes, synovitis, knee joint flexion and extension angles, swelling, walking ability, and quadriceps muscle atrophy were analyzed at 3, 5, 7, and 9 months. SAMP8 were required to run at a speed of 10 m/min for 15 min/day from 7 to 9 months of age. The knee joint pathologies and symptoms of exercising and non-exercising mice were compared by histological, immunohistochemical, and morphometrical analyses. Results: The mice presented with various histological changes, including cartilage destruction, osteocyte formation, synovitis, declined joint angles, and swelling. Notably, medial and posterior cartilage destruction was more severe than that of the lateral and anterior cartilage. Knee joint angles were significantly correlated with the histological scores (modified Mankin and OARSI, osteophyte formation and synovial lining cell layer). Exercise did not attenuate cartilage degeneration in the medial and posterior tibial plateau, although the articular cartilage of the anterior and lateral tibial plateau and its histological scores was remained and significantly improved, respectively, by exercise. Exercise suppressed the age-related decline of collagen type II-positive areas in the remaining articular cartilage and improved the OA symptoms. Exercise reduced the expression of monocyte chemoattractant protein (MCP)-1 and tumor necrosis factor (TNF)-α positive macrophages in the synovium. Conclusion: This study revealed that SAMP8 developed spontaneous knee OA with age, which resembled the disease symptoms in humans. Low-intensity exercise temporarily alleviated degeneration of the remaining cartilage, synovitis, and age-related decreases in knee flexion angle, stride length, and muscle atrophy in SAMP8. However, exercise during OA progression with age may cause mechanical stress that could be both beneficial and detrimental to joint health.

    DOI: 10.1186/s13075-023-03162-z

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  • Tani A., Sakakima H., Otsuka S., Mizuno K., Nakanishi K., Norimatsu K., Takada S., Matsuoka T., Matsuzaki R., Nakakogawa T., Maruyama I. .  Stimulation of functional recovery via neurorepair mechanisms by the traditional Japanese Kampo medicine, Ninjin'yoeito, and physical exercise in a rat ischemic stroke model .  Journal of Ethnopharmacology302 ( Pt B ) 115927   2023.2Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jep.2022.115927

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  • Otsuka S., Itashiki Y., Tani A., Matsuoka T., Takada S., Matsuzaki R., Nakanishi K., Norimatsu K., Tachibe Y., Kitazato R., Nojima N., Kakimoto S., Kikuchi K., Maruyama I., Sakakima H. .  Effects of different remote ischemia perconditioning methods on cerebral infarct volume and neurological impairment in rats .  Scientific Reports13 ( 1 ) 2158   2023.2Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-29475-2

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  • Sumizono M., Yoshizato Y., Yamamoto R., Imai T., Tani A., Nakanishi K., Nakakogawa T., Matsuoka T., Matsuzaki R., Tanaka T., Sakakima H. .  Mechanisms of Neuropathic Pain and Pain-Relieving Effects of Exercise Therapy in a Rat Neuropathic Pain Model .  Journal of Pain Research15   1925 - 1938   2022.6Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2147/JPR.S367818

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  • Takada S., Setoyama K., Norimatsu K., Otsuka S., Nakanishi K., Tani A., Nakakogawa T., Matsuzaki R., Matsuoka T., Sakakima H., Tancharoen S., Maruyama I., Tanaka E., Kikuchi K., Uchikado H. .  E8002 Reduces Adhesion Formation and Improves Joint Mobility in a Rat Model of Knee Arthrofibrosis .  International Journal of Molecular Sciences23 ( 3 )   2022.2Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms23031239

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  • 中西 和毅 , 中村 壮志, 小林 明日香, 松野 竜工, 下村 珠美, 宮﨑 雅司, 田邊 史, 井㞍 幸成, 榊間 春利 .  腰椎前外側椎体間固定術(OLIF)と後方椎体固定を 併用した腰椎変性側弯症患者の腹部筋再教育に 着目した術後理学療法 .  理学療法かごしま1   38 - 44   2022腰椎前外側椎体間固定術(OLIF)と後方椎体固定を 併用した腰椎変性側弯症患者の腹部筋再教育に 着目した術後理学療法Reviewed

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.57357/ptkagoshima.1.0_38

  • Otsuka S., Setoyama K., Takada S., Nakanishi K., Terashi T., Norimatsu K., Tani A., Sakakima H., Maruyama I., Tancharoen S., Tanaka E., Kikuchi K. .  Preconditioning Exercise in Rats Attenuates Early Brain Injury Resulting from Subarachnoid Hemorrhage by Reducing Oxidative Stress, Inflammation, and Neuronal Apoptosis .  Molecular Neurobiology58 ( 11 ) 5602 - 5617   2021.8Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12035-021-02506-7

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  • Otsuka S., Sakakima H., Tani A., Nakanishi K., Takada S., Norimatsu K., Maejima H., Maruyama I. .  Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats .  Brain Structure and Function226 ( 7 ) 2169 - 2180   2021.6Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00429-021-02317-5

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  • Harutoshi Sakakima, Seiya Takada, Kosuke Norimatsu, Shotaro Otsuka, Kazuki Nakanishi, Akira Tani .  Diurnal Profiles of Locomotive and Household Activities Using an Accelerometer in Community-Dwelling Older Adults with Musculoskeletal Disorders: A Cross-Sectional Survey. .  International journal of environmental research and public health17 ( 15 ) 5337   2020.7Diurnal Profiles of Locomotive and Household Activities Using an Accelerometer in Community-Dwelling Older Adults with Musculoskeletal Disorders: A Cross-Sectional Survey.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijerph17155337

  • Kiyoshi Kikuchi, Kentaro Setoyama, Seiya Takada, Shotaro Otsuka, Kazuki Nakanishi, Kosuke Norimatsu, Akira Tani, Harutoshi Sakakima, Ko-Ichi Kawahara, Kazuya Hosokawa, Ryoji Kiyama, Megumi Sumizono, Salunya Tancharoen, Ikuro Maruyama, Gohsuke Hattori, Motohiro Morioka, Eiichiro Tanaka, Hisaaki Uchikado .  E8002 Inhibits Peripheral Nerve Adhesion by Enhancing Fibrinolysis of l-Ascorbic Acid in a Rat Sciatic Nerve Model. .  International journal of molecular sciences21 ( 11 ) 3972   2020.6E8002 Inhibits Peripheral Nerve Adhesion by Enhancing Fibrinolysis of l-Ascorbic Acid in a Rat Sciatic Nerve Model.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms21113972

  • Seiya Takada, Harutoshi Sakakima, Takahiro Matsuyama, Shotaro Otsuka, Kazuki Nakanishi, Kosuke Norimatsu, Yuki Itashiki, Akira Tani, Kiyoshi Kikuchi .  Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation. .  Journal of neuroinflammation17 ( 1 ) 40   2020.1Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12974-020-1709-8

  • 谷 明, 藤川 寿史, 中西 和毅, 高田 聖也, 則松 貢輔, 大塚 章太郎, 宮崎 雅司, 榊間 春利 .  腰椎術後患者の安静、Draw-in、頭部挙上による側腹筋筋厚変化 .  形態・機能18 ( 1 ) 2 - 8   2019.8腰椎術後患者の安静、Draw-in、頭部挙上による側腹筋筋厚変化Reviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Takuto Terashi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Koki Ueda, Megumi Sumizono, Kiyoshi Kikuchi, Harutoshi Sakakima .  Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats. .  Neurological research41 ( 6 ) 510 - 518   2019.6Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/01616412.2019.1580458

  • Shotaro Otsuka, Harutoshi Sakakima, Takuto Terashi, Seiya Takada, Kazuki Nakanishi, Kiyoshi Kikuchi .  Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats. .  Brain structure & function224 ( 2 ) 739 - 740   2019.3Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00429-018-1800-4

  • Kiyoshi Kikuchi, Kentaro Setoyama, Eiichiro Tanaka, Shotaro Otsuka, Takuto Terashi, Kazuki Nakanishi, Seiya Takada, Harutoshi Sakakima, Sumate Ampawong, Ko-Ichi Kawahara, Tomoka Nagasato, Kazuya Hosokawa, Yoichiro Harada, Mika Yamamoto, Chinatsu Kamikokuryo, Ryoji Kiyama, Motohiro Morioka, Takashi Ito, Ikuro Maruyama, Salunya Tancharoen .  Uric acid enhances alteplase-mediated thrombolysis as an antioxidant.  .  Scientific reports8 ( 1 ) 15844   2018.10Uric acid enhances alteplase-mediated thrombolysis as an antioxidant. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-34220-1

  • Kiyoshi Kikuchi, Kentaro Setoyama, Takuto Terashi, Megumi Sumizono, Salunya Tancharoen, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Koki Ueda, Harutoshi Sakakima, Ko-Ichi Kawahara, Ikuro Maruyama, Gohsuke Hattori, Motohiro Morioka, Eiichiro Tanaka, Hisaaki Uchikado .  Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model.  .  International journal of molecular sciences19 ( 5 ) 1513   2018.5Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms19051513

  • Megumi Sumizono, Harutoshi Sakakima, Shotaro Otsuka, Takuto Terashi, Kazuki Nakanishi, Koki Ueda, Seiya Takada, Kiyoshi Kikuchi .  The effect of exercise frequency on neuropathic pain and pain-related cellular reactions in the spinal cord and midbrain in a rat sciatic nerve injury model.  .  Journal of pain research11   281 - 291   2018.2The effect of exercise frequency on neuropathic pain and pain-related cellular reactions in the spinal cord and midbrain in a rat sciatic nerve injury model. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2147/JPR.S156326

  • Kiyoshi Kikuchi, Kentaro Setoyama, Ko-Ichi Kawahara, Tomoka Nagasato, Takuto Terashi, Koki Ueda, Kazuki Nakanishi, Shotaro Otsuka, Naoki Miura, Hisayo Sameshima, Kazuya Hosokawa, Yoichiro Harada, Binita Shrestha, Mika Yamamoto, Yoko Morimoto-Yamashita, Haruna Kikuchi, Ryoji Kiyama, Chinatsu Kamikokuryo, Salunya Tancharoen, Harutoshi .  Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis. .  Oxidative medicine and cellular longevity2017   6873281   2017.11Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2017/6873281

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Presentations

  • 中島 悠輔, 足立 貴志, 橘木 康文, 中西 和毅, 榊間 春利, 井尻 幸成   投球動作中の肘関節の関連性について  

    理学療法学  2021.12  (一社)日本理学療法学会連合

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    Language:Japanese  

  • 中小川 智美, 松崎 凌真, 松岡 輝樹, 則松 貢輔, 谷 明, 中西 和毅, 高田 聖也, 大塚 章太郎, 稲留 真輝, 柿本 翔吾, 加藤 夕貴, 立部 勇汰, 野島 菜央, 日高 優悟, 榊間 春利   運動と緑茶カテキン摂取が変形性膝関節症モデルマウスの疼痛発現や脊髄グリア細胞の活性化に及ぼす影響  

    形態・機能  2022.8  コ・メディカル形態機能学会

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    Language:Japanese  

  • Norimatsu Kosuke, Nakanishi Kazuki, Tani Akira, Fukumaru Keita, Otsuka Shotaro, Takada Seiya, Sakakima Harutoshi   老化促進マウスモデル(SAMP8)の膝関節における加齢変化と運動の効果について(Effects of aging and balance exercise on the knee joint of the senescence accelerated mouse(SAMP8))  

    The Journal of Physiological Sciences  2021.8  (一社)日本生理学会

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    Language:English  

  • 則松 貢輔, 中西 和毅, 谷 明, 松岡 輝樹, 松崎 凌真, 中小川 智美, 大塚 章太郎, 高田 聖也, 榊間 春利   老化促進マウスにおける関節軟骨変性に及ぼす種々のメカニカルストレスの影響について  

    形態・機能  2021.8  コ・メディカル形態機能学会

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    Language:Japanese  

  • 新留 卓弥, 善福 大輔, 井尻 幸成, 中西 和毅, 榊間 春利, 山浦 一郎   投球時に肘下がりを生じる中学野球投手の特徴 筋力と関節可動域の関係性  

    日本臨床スポーツ医学会誌  2021.10  (一社)日本臨床スポーツ医学会

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    Language:Japanese  

  • 則松 貢輔, 中西 和毅, 谷 明, 松崎 凌真, 中小川 智美, 松岡 輝樹, 大塚 章太郎, 高田 聖也, 角園 恵, 榊間 春利   老化促進マウスにおける低強度トレッドミル運動は加齢による変形性膝関節症の進行を緩和する  

    基礎理学療法学  2023.1  (一社)日本基礎理学療法学会

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    Language:Japanese  

  • 松崎 凌真, 中小川 智美, 松岡 輝樹, 谷 明, 則松 貢輔, 中西 和毅, 高田 聖也, 大塚 章太郎, 榊間 春利   緑茶カテキン摂取と運動療法の併用が老化促進マウス(SAMP8)の骨格筋に及ぼす影響  

    基礎理学療法学  2023.1  (一社)日本基礎理学療法学会

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    Language:Japanese  

  • 角園 恵, 吉里 雄伸, 今井 孝樹, 中西 和毅, 谷 明, 松崎 凌真, 中小川 智美, 松岡 輝樹, 榊間 春利   神経因性疼痛のメカニズムと神経因性疼痛ラットモデルにおける運動療法の鎮痛効果  

    基礎理学療法学  2023.1  (一社)日本基礎理学療法学会

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    Language:Japanese  

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Awards

  • 学会奨励賞

    2018.9   コ・メディカル形態機能学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Research Projects

  • 遠隔虚血コンディショニングによる認知症予防の新規介入方法の開発と作用機序の解明

    Grant number:23K16543  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  若手研究

    中西和毅

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  • 予防的運動介入がグリア細胞分極や神経生存と行動学的評価に与える影響の解明

    Grant number:20J14080  2020.4 - 2022.3

    日本学術振興会  科学研究費助成事業 特別研究員奨励費  特別研究員奨励費

    中西 和毅

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    Grant amount:\2100000 ( Direct Cost: \2100000 )