Updated on 2024/10/03

写真a

 
Ando Masahiro
 
Organization
University Hospital, Medical and Dental Sciences Area University Hospital Clinical Center Neurology Disease Center Assistant Professor
Title
Assistant Professor

Degree

  • 博士(医学) ( 2018.4 )

Research Interests

  • Neurogenetics

  • Charcot-Marie-Tooth disease

  • Hereditary ataxia

  • Bioinformatics

  • R

Research Areas

  • Life Science / Neurology

  • Life Science / Genetics

Research History

  • Kagoshima University   Assistant Professor

    2023.11

  • Kagoshima University   Assistant Professor

Professional Memberships

  • 神経治療学会

  • 末梢神経学会

  • 人類遺伝学会

  • 日本神経学会

  • 日本内科学会

 

Papers

  • Hobara T, Higuchi Y, Yoshida M, Suehara M, Ando M, Yuan JH, Yoshimura A, Kojima F, Matsuura E, Okamoto Y, Mitsui J, Tsuji S, Takashima H. .  Genetic and pathophysiological insights from autopsied patient with primary familial brain calcification: novel MYORG variants and astrocytic implications. .  Acta Neuropathol Commun.   2024.8Genetic and pathophysiological insights from autopsied patient with primary familial brain calcification: novel MYORG variants and astrocytic implications.

  • Hobara T, Ando M, Higuchi Y, Yuan JH, Yoshimura A, Kojima F, Noguchi Y, Takei J, Hiramatsu Y, Nozuma S, Nakamura T, Adachi T, Toyooka K, Yamashita T, Sakiyama Y, Hashiguchi A, Matsuura E, Okamoto Y, Takashima H. .  Linking LRP12 CGG repeat expansion to inherited peripheral neuropathy. .  J Neurol Neurosurg Psychiatry   2024.6 Linking LRP12 CGG repeat expansion to inherited peripheral neuropathy.

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  • Kojima F, Okamoto Y, Ando M, Higuchi Y, Hobara T, Yuan J, Yoshimura A, Hashiguchi A, Matsuura E, Takashima H. .  A novel homozygous HPDL variant in Japanese siblings with autosomal recessive hereditary spastic paraplegia: case report and literature review. .  Neurogenetics25 ( 2 ) 149 - 156   2024.4A novel homozygous HPDL variant in Japanese siblings with autosomal recessive hereditary spastic paraplegia: case report and literature review. Reviewed

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    Language:English  

  • Clinical variability associated with intronic FGF14 GAA repeat expansion in Japan. Ando M, Higuchi Y, Yuan J, Yoshimura A, Kojima F, Yamanishi Y, Aso Y, Izumi K, Imada M, Maki Y, Nakagawa H, Hobara T, Noguchi Y, Takei J, Hiramatsu Y, Nozuma S, Sakiyama Y, Hashiguchi A, Matsuura E, Okamoto Y, Takashima H. .  Clinical variability associated with intronic FGF14 GAA repeat expansion in Japan .  Ann Clin Transl Neurol.   2024.1Clinical variability associated with intronic FGF14 GAA repeat expansion in JapanReviewed

  • Hirano M, Kuwahara M, Yamagishi Y, Samukawa M, Fujii K, Yamashita S, Ando M, Oka N, Nagano M, Matsui T, Takeuchi T, Saigoh K, Kusunoki S, Takashima H, Nagai Y. .  CANVAS-related RFC1 mutations in patients with immune-mediated neuropathy .  Sci Rep   2023.10CANVAS-related RFC1 mutations in patients with immune-mediated neuropathyReviewed

  • Higuchi Y, Ando M, Kojima F, Yuan J, Hashiguchi A, Yoshimura A, Hiramatsu Y, Nozuma S, Fukumura S, Yahikozawa H, Abe E, Toyoshima I, Sugawara M, Okamoto Y, Matsuura E, Takashima H. .  Dystonia and Parkinsonism in COA7-related disorders: expanding the phenotypic spectrum .  J Neurol   2023.9Dystonia and Parkinsonism in COA7-related disorders: expanding the phenotypic spectrumReviewed

  • Yuan JH, Cheng X, Matsuura E, Higuchi Y, Ando M, Hashiguchi A, Yoshimura A, Nakachi R, Mine J, Taketani T, Maeda K, Kawakami S, Kira R, Tanaka S, Kanai K, Dib-Hajj F, Dib-Hajj SD, Waxman SG, Takashima H. .  Genetic, electrophysiological, and pathological studies on patients with SCN9A-related pain disorders. .  J Peripher Nerv Syst   2023.8Genetic, electrophysiological, and pathological studies on patients with SCN9A-related pain disorders.

  • Takei J, Higuchi Y, Ando M, Yoshimura A, Yuan JH, Fujisaki N, Tokashiki T, Kanzato N, Jonosono M, Sueyoshi T, Kanda N, Matsuoka H, Okubo R, Suehara M, Matsuura E, Takashima H. .  Microbleed clustering in thalamus sign in CADASIL patients with NOTCH3 R75P mutation. .  Front Neurol.   2023.8Microbleed clustering in thalamus sign in CADASIL patients with NOTCH3 R75P mutation.

  • Ando M, Higuchi Y, Yuan JH, Yoshimura A, Dozono M, Hobara T, Kojima F, Noguchi Y, Takeuchi M, Takei J, Hiramatsu Y, Nozuma S, Nakamura T, Sakiyama Y, Hashiguchi A, Matsuura E, Okamoto Y, Sone J, Takashima H. .  Clinical phenotypic diversity of NOTCH2NLC-related disease in the largest case series of inherited peripheral neuropathy in Japan .  J Neurol Neurosurg Psychiatry   2023.3Clinical phenotypic diversity of NOTCH2NLC-related disease in the largest case series of inherited peripheral neuropathy in JapanReviewed

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  • Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder. Front Neurol .  Front Neurol13 ( 14 ) 1137958 - 1137958   2023.2Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder. Front NeurolReviewed

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    Language:English  

  • Gene panel analysis of 119 index patients with suspected periodic paralysis in Japan .  Front Neurol26 ( 14 ) 1078195 - 1078195   2023.1Gene panel analysis of 119 index patients with suspected periodic paralysis in JapanReviewed

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    Language:English  

  • Siblings with Cockayne Syndrome B Type III Presenting with Slowly Progressive Cerebellar Ataxia. .  Intern Med62 ( 15 ) 2253 - 2259   2023Siblings with Cockayne Syndrome B Type III Presenting with Slowly Progressive Cerebellar Ataxia. Reviewed

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  • Imoto M, Nakamura K, Inoue K, Ando M, Higuchi Y, Takashima H, Okuda S. .  [Involvement of autonomic nervous system since middle age in elderly patient with giant axonal neuropathy caused by novel genetic mutation]. .  Rinsho Shinkeigaku.   2023[Involvement of autonomic nervous system since middle age in elderly patient with giant axonal neuropathy caused by novel genetic mutation].

  • 井元 万紀子, 中村 航大, 井上 貴美子, 安藤 匡宏, 樋口 雄二郎, 髙嶋 博, 奥田 志保 .  中高年以降に自律神経障害を併発し,GAN新規変異を認めた巨大軸索ニューロパチーの1例 .  臨床神経学63 ( 9 ) 566 - 571   2023中高年以降に自律神経障害を併発し,GAN新規変異を認めた巨大軸索ニューロパチーの1例

  • Nozuma S, Matsuura E, Tashiro Y, Nagata R, Ando M, Hiramatsu Y, Higuchi Y, Sakiyama Y, Hashiguchi A, Michizono K, Higashi K, Matsuzaki T, Kodama D, Tanaka M, Yamano Y, Moritoyo T, Kubota R, Takashima H. .  Efficacy of L-Arginine treatment in patients with HTLV-1- associated neurological disease .  Ann Clin Transl Neurol   2022Efficacy of L-Arginine treatment in patients with HTLV-1- associated neurological disease

  • Yuan JH, Higuchi Y, Ando M, Matsuura E, Hashiguchi A, Yoshimura A, Nakamura T, Sakiyama Y, Mitsui J, Ishiura H, Tsuji S, Takashima H .  Multi-type RFC1 repeat expansions as the most common cause of hereditary sensory and autonomic neuropathy .  Front Neurol17 ( 13 ) 986504   2022Multi-type RFC1 repeat expansions as the most common cause of hereditary sensory and autonomic neuropathyReviewed

  • Ando M, Higuchi Y, Yuan JH, Yoshimura A, Higashi S, Takeuchi M, Hobara T, Kojima F, Noguchi Y, Takei J, Hiramatsu Y, Nozuma S, Sakiyama Y, Hashiguchi A, Matsuura E, Okamoto Y, Nagai M, Takashima H .  Genetic and clinical features of cerebellar ataxia with RFC1 biallelic repeat expansions in Japan .  Front Neurol10 ( 13 ) 952493   2022Genetic and clinical features of cerebellar ataxia with RFC1 biallelic repeat expansions in JapanReviewed

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  • Yuan JH, Higuchi Y, Hashiguchi A, Ando M, Yoshimura A, Nakamura T, Sakiyama Y, Takashima H. .  Genetic spectrum and founder effect of non-dystrophic myotonia: a Japanese case series study .  J Neurol269 ( 12 ) 6406 - 6415   2022Genetic spectrum and founder effect of non-dystrophic myotonia: a Japanese case series studyReviewed

  • Ando M, Higuchi Y, Yuan J, Yoshimura A, Taniguchi T, Kojima F, Noguchi Y, Hobara T, Takeuchi M, Takei J, Hiramatsu Y, Sakiyama Y, Hashiguchi A, Okamoto Y, Mitsui J, Ishiura H, Tsuji S, Takashima H .  Comprehensive Genetic Analyses of Inherited Peripheral Neuropathies in Japan: Making Early Diagnosis Possible .  Biomedicines10 ( 7 ) 1546   2022Comprehensive Genetic Analyses of Inherited Peripheral Neuropathies in Japan: Making Early Diagnosis PossibleReviewed

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  • Ando M, Higuchi Y, Yuan J, Yoshimura A, Taniguchi T, Takei J, Takeuchi M, Hiramatsu Y, Shimizu F, Kubota M, Takeshima A, Ueda T, Koh K, Nagaoka U, Tokashiki T, Sawai S, Sakiyama Y, Hashiguchi A, Sato R, Kanda T, Okamoto Y, Takashima H .  Novel heterozygous variants of SLC12A6 in Japanese families with Charcot-Marie-Tooth disease .  Ann Clin Transl Neurol9 ( 7 ) 902 - 911   2022Novel heterozygous variants of SLC12A6 in Japanese families with Charcot-Marie-Tooth diseaseReviewed

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  • Ando M, Higuchi Y, Yuan JH, Yoshimura A, Kitao R, Morimoto T, Taniguchi T, Takeuchi M, Takei J, Hiramatsu Y, Sakiyama Y, Hashiguchi A, Okamoto Y, Mitsui J, Ishiura H, Tsuji S, Takashima H .  Novel de novo POLR3B mutations responsible for demyelinating Charcot-Marie-Tooth disease in Japan .  Ann Clin Transl Neurol9 ( 5 ) 747 - 755   2022Novel de novo POLR3B mutations responsible for demyelinating Charcot-Marie-Tooth disease in JapanReviewed

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  • Hiramatsu Y, Okamoto Y, Yoshimura A, Yuan JH, Ando M, Higuchi Y, Hashiguchi A, Matsuura E, Nozaki F, Kumada T, Murayama K, Suzuki M, Yamamoto Y, Matsui N, Miyazaki Y, Yamaguchi M, Suzuki Y, Mitsui J, Ishiura H, Tanaka M, Morishita S, Nishino I, Tsuji S, Takashima H .  Complex hereditary peripheral neuropathies caused by novel variants in mitochondrial-related nuclear genes .  J Neurol269 ( 8 ) 4129 - 4140   2022Complex hereditary peripheral neuropathies caused by novel variants in mitochondrial-related nuclear genesReviewed

  • Ando M, Higuchi Y, Okamoto Y, Yuan J, Yoshimura A, Takei J, Taniguchi T, Hiramatsu Y, Sakiyama Y, Hashiguchi A, Matsuura E, Nakagawa H, Sonoda K, Yamashita T, Tamura A, Terasawa H, Mitsui J, Ishiura H, Tsuji S, Takashima H .  An NEFH founder mutation causes broad phenotypic spectrum in multiple Japanese families .  J Hum Genet67 ( 7 ) 399 - 403   2022An NEFH founder mutation causes broad phenotypic spectrum in multiple Japanese familiesReviewed

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  • Taniguchi T, Ando M, Okamoto Y, Yoshimura A, Higuchi Y, Hashiguchi A, Matsuda N, Yamamoto M, Dohi E, Takahashi M, Yoshino M, Nomura T, Matsushima M, Yabe I, Sanpei Y, Ishiura H, Mitsui J, Nakagawa M, Tsuji S, Takashima H .  Elderly patients with suspected Charcot-Marie-Tooth disease should be tested for the TTR gene for effective treatments .  J Hum Genet67 ( 6 ) 353 - 362   2022Elderly patients with suspected Charcot-Marie-Tooth disease should be tested for the TTR gene for effective treatmentsReviewed

  • Ando M, Higuchi Y, Takeuchi M, Hashiguchi A, Takashima H .  The first case of infantile-onset multisystem neurologic, endocrine, and pancreatic disease caused by novel PTRH2 mutation in Japan .  Neurol Sci43 ( 3 ) 2133 - 2136   2022The first case of infantile-onset multisystem neurologic, endocrine, and pancreatic disease caused by novel PTRH2 mutation in JapanReviewed

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  • Taniguchi T, Ando M, Okamoto Y, Yoshimura A, Higuchi Y, Hashiguchi A, Shiga K, Hayashida A, Hatano T, Ishiura H, Mitsui J, Hattori N, Mizuno T, Nakagawa M, Tsuji S, Takashima H .  Genetic spectrum of Charcot-Marie-Tooth disease associated with myelin protein zero gene variants in Japan .  Clin Gene99 ( 3 ) 359 - 375   2021Genetic spectrum of Charcot-Marie-Tooth disease associated with myelin protein zero gene variants in JapanReviewed

  • Higuchi Y, Ando M, Yoshimura A, Hakotani S, Koba Y, Sakiyama Y, Hiramatsu Y, Tashiro Y, Maki Y, Hashiguchi A, Yuan J, Okamoto Y, Matsuura E, Takashima .  Prevalence of Fragile X-Associated Tremor/Ataxia Syndrome in Patients with Cerebellar Ataxia in Japan .  Cerebellum21 ( 5 ) 851 - 860   2021Prevalence of Fragile X-Associated Tremor/Ataxia Syndrome in Patients with Cerebellar Ataxia in JapanReviewed

  • 丸田恭子 安藤匡宏, 大友孝信, 高嶋 博 .  AP5Z1遺伝子に新規変異を認めたspastic paraplegia48の1例 .    60 ( 8 ) 543 - 548   2020AP5Z1遺伝子に新規変異を認めたspastic paraplegia48の1例Reviewed

  • Yoshimura A, Yuan JH, Hashiguchi A, Ando M, Higuchi Y, Nakamura T, Okamoto Y, Nakagawa M, Takashima H .  Genetic profile and onset features of 1005 patients with Charcot-Marie-Tooth disease in Japan .  J Neurol Neurosurg Psychiatry90 ( 2 ) 195 - 202   2019Genetic profile and onset features of 1005 patients with Charcot-Marie-Tooth disease in JapanReviewed

  • Sakiyama Y, Matsuura E, Maki Y, Yoshimura A, Ando M, Nomura M, Shinohara K, Saigo R, Nakamura T, Hashiguchi A, Takashima H .  Peripheral neuropathy in a case with CADASIL: a case report .  BMC Neurol18 ( 1 ) 134   2018Peripheral neuropathy in a case with CADASIL: a case reportReviewed

  • Yuan JH, Sakiyama Y, Hashiguchi A, Ando M, Okamoto Y, Yoshimura A, Higuchi Y, Takashima H .  Genetic and phenotypic profile of 112 patients with X-linked Charcot-Marie-Tooth disease type 1 .  Eur J Neurol25 ( 12 ) 1454 - 1461   2018Genetic and phenotypic profile of 112 patients with X-linked Charcot-Marie-Tooth disease type 1Reviewed

  • Higuchi Y, Okunushi R, Hara T, Hashiguchi A, Yuan J, Yoshimura A, Murayama K, Ohtake A, Ando M, Hiramatsu Y, Ishihara S, Tanabe H, Okamoto Y, Matsuura E, Ueda T, Toda T, Yamashita S, Yamada K, Koide T, Yaguchi H, Mitsui J, Ishiura H, Yoshimura J, Doi K, Morishita S, Sato K, Nakagawa M, Yamaguchi M, Tsuji S, Takashima .  Mutations in COA7 cause spinocerebellar ataxia with axonal neuropathy .  Brain141 ( 6 ) 1622 - 1636   2018Mutations in COA7 cause spinocerebellar ataxia with axonal neuropathyReviewed

  • Yuan JH, Hashiguchi A, Okamoto Y, Yoshimura A, Ando M, Shiomi K, Saito K, Takahashi M, Ichinose K, Ohmichi T, Ichikawa K, Tadashi A, Takigawa H, Shibayama H, Takashima H .  Clinical and mutational spectrum of Japanese patients with recessive variants in SH3TC2 .  J Hum Genet63 ( 31 ) 281 - 287   2018Clinical and mutational spectrum of Japanese patients with recessive variants in SH3TC2Reviewed

  • Yoshimura A, Yuan JH, Hashiguchi A, Hiramatsu Y, Ando M, Higuchi Y, Nakamura T, Okamoto Y, Matsumura K, Hamano T, Sawaura N, Shimatani Y, Kumada S, Okumura Y, Miyahara J, Yamaguchi Y, Kitamura S, Haginoya K, Mitsui J, Ishiura H, Tsuji S, Takashima H .  Clinical and mutational spectrum of Japanese patients with Charcot-Marie-Tooth disease caused by GDAP1 variants .  Clin Genet92 ( 3 ) 274 - 280   2017Clinical and mutational spectrum of Japanese patients with Charcot-Marie-Tooth disease caused by GDAP1 variantsReviewed

  • Ando M, Okamoto Y, Yoshimura A, Yuan JH, Hiramatsu Y, Higuchi Y, Hashiguchi A, Mitsui J, Ishiura H, Fukumura S, Matsushima M, Ochi N, Tsugawa J, Morishita S, Tsuji S, Takashima H .  Clinical and mutational spectrum of Charcot-Marie-Tooth disease type 2Z caused by MORC2 variants in Japan .  Eur J Neurol24 ( 10 ) 1274 - 1282   2017Clinical and mutational spectrum of Charcot-Marie-Tooth disease type 2Z caused by MORC2 variants in JapanReviewed

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  • Ando M, Hashiguchi A, Okamoto Y, Yoshimura A, Hiramatsu Y, Yuan J, Higuchi Y, Mitsui J, Ishiura H, Umemura A, Maruyama K, Matsushige T, Morishita S, Nakagawa M, Tsuji S, Takashima H .  Clinical and genetic diversities of Charcot-Marie-Tooth disease with MFN2 mutations in a large case study .  J Peripher Nerv Syst22 ( 3 ) 191 - 199   2017Clinical and genetic diversities of Charcot-Marie-Tooth disease with MFN2 mutations in a large case studyReviewed

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  • Yuan JH, Hashiguchi A, Yoshimura A, Sakai N, Takahashi MP, Ueda T, Taniguchi A, Okamoto S, Kanazawa N, Yamamoto Y, Saigoh K, Kusunoki S, Ando M, Hiramatsu Y, Okamoto Y, Takashima H .  WNK1/HSN2 founder mutation in patients with hereditary sensory and autonomic neuropathy: A Japanese cohort study. .  Clin Genet92 ( 6 ) 659 - 663   2017WNK1/HSN2 founder mutation in patients with hereditary sensory and autonomic neuropathy: A Japanese cohort study.Reviewed

  • Yuan JH, Hashiguchi A, Yoshimura A, Yaguchi H, Tsuzaki K, Ikeda A, Wada-Isoe K, Ando M, Nakamura T, Higuchi Y, Hiramatsu Y, Okamoto Y, Takashima H. .  Clinical diversity caused by novel IGHMBP2 variants. .  J Hum Genet62 ( 6 ) 599 - 604   2017Clinical diversity caused by novel IGHMBP2 variants.Reviewed

  • Yuan J, Ando M, Higuchi I, Sakiyama Y, Matsuura E, Michizono K, Watanabe O, Nagano S, Inamori Y, Hashiguchi A, Higuchi Y, Yoshimura A, Takashima H .  Partial deficiency of emerin caused by a splice site mutation in EMD .  Intern Med53 ( 14 ) 1563 - 1568   2014Partial deficiency of emerin caused by a splice site mutation in EMDReviewed

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Research Projects

  • 遺伝性ニューロパチーの分子疫学的研究-新規原因遺伝子探索とリピート異常伸張

    2023.4 - 2026.3

    科学研究費補助金 基盤研究(C) 

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    Authorship:Principal investigator 

  • R言語を用いた次世代シークエンサーの網羅的解析パイプラインの構築

    2021.4 - 2023.3

    科学研究費補助金 若手研究 

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    Authorship:Principal investigator