Updated on 2024/02/08

写真a

 
NAKATA Masanobu
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Health Research Course Developmental Medicine Professor
Title
Professor

Degree

  • 博士 (歯学) ( 2001.3   大阪大学 )

Research Interests

  • Bacteriology

Research Areas

  • Life Science / Oral pathobiological science

Research History

  • Kagoshima University   Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Health Research Course Developmental Medicine   Professor

    2020.7

Professional Memberships

  • 歯科基礎医学会

    2008.6

  • 日本細菌学会

    2007.1

  • JAPANESE ASSOCIATION FOR ORAL BIOLOGY

  • JAPANESE SOCIETY FOR BACTERIOLOGY

  • American Society for Microbiology

 

Papers

  • Takebe K, Suzuki M, Sangawa T, Kreikemeyer B, Yamaguchi M, Uzawa N, Sumitomo T, Kawabata S, Nakata M. .  Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms. .  Archives in Microbiology   2023.11Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms.Reviewed International coauthorship

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00203-023-03727-1.

  • Seiko Kubota, Masanobu Nakata, Yujiro Hirose, Masaya Yamaguchi, Bernd Kreikemeyer, Narikazu Uzawa, Tomoko Sumitomoa, Shigetada Kawabata .  Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of mRNA level of transcriptional regulator .  Microbiology and Immunology   2023Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of mRNA level of transcriptional regulatorReviewed International coauthorship

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Nobuo Okahashi, Masanobu Nakata, Hirotaka Kuwata, Shigetada Kawabata .  Oral mitis group streptococci: a silent majority in our oral cavity .  Microbiology and Immunology66 ( 12 ) 539 - 551   2022.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/1348-0421.13028

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  • Nakazono K, Le MN, Kawada-Matsuo M, Kimheang N, Hisatsune J, Oogai Y, Nakata M, Nakamura N, Sugai M, Komatsuzawa H. .  Complete sequences of epidermin and nukacin encoding plasmids from oral-derived Staphylococcus epidermidis and their antibacterial activity. .  PLoS One17 ( 1 ) e0258283   2022Complete sequences of epidermin and nukacin encoding plasmids from oral-derived Staphylococcus epidermidis and their antibacterial activity.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0258283.

  • Okahashi N, Sumitomo T, Nakata M, Kawabata S. .  Secondary streptococcal infection following influenza. .  Microbiol Immunol.   2022Secondary streptococcal infection following influenza.Reviewed

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    DOI: 10.1111/1348-0421.12965.

  • Takemura, M., Yamaguchi, M., Kobayashi, M., ...Uzawa, N., Kawabata .  Pneumococcal BgaA Promotes Host Organ Bleeding and Coagulation in a Mouse Sepsis Model .      2022Pneumococcal BgaA Promotes Host Organ Bleeding and Coagulation in a Mouse Sepsis ModelReviewed

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  • Nobuo Okahashi, Tomoko Sumitomo, Masanobu Nakata, Hirotaka Kuwata, Shigetada Kawabata .  Oral mitis group streptococci reduce infectivity of influenza A virus via acidification and H2O2 production. .  PloS one17 ( 11 ) e0276293   2022International journal

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    Members of the mitis group streptococci are the most abundant inhabitants of the oral cavity and dental plaque. Influenza A virus (IAV), the causative agent of influenza, infects the upper respiratory tract, and co-infection with Streptococcus pneumoniae is a major cause of morbidity during influenza epidemics. S. pneumoniae is a member of mitis group streptococci and shares many features with oral mitis group streptococci. In this study, we investigated the effect of viable Streptococcus oralis, a representative member of oral mitis group, on the infectivity of H1N1 IAV. The infectivity of IAV was measured by a plaque assay using Madin-Darby canine kidney cells. When IAV was incubated in growing culture of S. oralis, the IAV titer decreased in a time- and dose-dependent manner and became less than 100-fold, whereas heat-inactivated S. oralis had no effect. Other oral streptococci such as Streptococcus mutans and Streptococcus salivarius also reduced the viral infectivity to a lesser extent compared to S. oralis and Streptococcus gordonii, another member of the oral mitis group. S. oralis produces hydrogen peroxide (H2O2) at a concentration of 1-2 mM, and its mutant deficient in H2O2 production showed a weaker effect on the inactivation of IAV, suggesting that H2O2 contributes to viral inactivation. The contribution of H2O2 was confirmed by an inhibition assay using catalase, an H2O2-decomposing enzyme. These oral streptococci produce short chain fatty acids (SCFA) such as acetic acid as a by-product of sugar metabolism, and we also found that the inactivation of IAV was dependent on the mildly acidic pH (around pH 5.0) of these streptococcal cultures. Although inactivation of IAV in buffers of pH 5.0 was limited, incubation in the same buffer containing 2 mM H2O2 resulted in marked inactivation of IAV, which was similar to the effect of growing S. oralis culture. Taken together, these results reveal that viable S. oralis can inactivate IAV via the production of SCFAs and H2O2. This finding also suggests that the combination of mildly acidic pH and H2O2 at low concentrations could be an effective method to inactivate IAV.

    DOI: 10.1371/journal.pone.0276293

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  • Comprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutans .    66 ( 3 ) 145 - 156   2022Comprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutans

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  • Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S .  GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection .  mBio   e0326920   2021.6GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infectionReviewed

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    DOI: 10.1128/mBio.03269-20

  • Expression of virulence factors under different environmental conditions in Aggregatibacter actinomycetemcomitans .    65 ( 3 ) 101 - 114   2021.3Expression of virulence factors under different environmental conditions in Aggregatibacter actinomycetemcomitans

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  • Hirose, Y., Yamaguchi, M., Sumitomo, T., Nakata, M., Hanada, T., Okuzaki, D., Motooka, D., Mori, Y., Kawasaki, H., Coady, A., Uchiyama, S., Hiraoka, M., Zurich, R., Riestra, A., Amagai, M., Nizet, V., Kawabata, S. .  Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface. .  Cell Reports34 ( 13 ) 108924   2021Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface.Invited Reviewed International coauthorship

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.202

  • Nakata, M, Kreikemeyer, B .  Genetics, Structure, and Function of Group A Streptococcal Pili .  Frontiers in Microbiology12   616508   2021Genetics, Structure, and Function of Group A Streptococcal Pili

  • Ayumi Fujita, Yuichi Oogai, Miki Kawada-Matsuo, Masanobu Nakata, Kazuyuki Noguchi, Hitoshi Komatsuzawa .  Expression of virulence factors under different environmental conditions in Aggregatibacter actinomycetemcomitans .  Microbiology and Immunology65 ( 3 ) 101 - 114   2021Expression of virulence factors under different environmental conditions in Aggregatibacter actinomycetemcomitans

  • Watanabe A, Kawada-Matsuo M, Le MN, Hisatsune J, Oogai Y, Nakano Y, Nakata M, Miyawaki S, Sugai M, Komatsuzawa H. .  Comprehensive analysis of bacteriocins in Streptococcus mutans. .  Sci Rep.11 ( 1 ) 12963   2021Comprehensive analysis of bacteriocins in Streptococcus mutans. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-92370-1.

  • Katsumata T, Nguyen-Tra Le M, Kawada-Matsuo M, Taniguchi Y, Ouhara K, Oogai Y, Nakata M, Mizuno N, Nishitani Y, Komatsuzawa H. .  Comprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutans. .  Microbiol Immunol.   2021Comprehensive characterization of sortase A-dependent surface proteins in Streptococcus mutans.

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  • Oogai Y, Nakata M. .  Small regulatory RNAs of oral streptococci and periodontal bacteria. .  Jpn Dent Sci Rev. 57   209 - 216   2021Small regulatory RNAs of oral streptococci and periodontal bacteria. Invited Reviewed

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    DOI: 10.1016/j.jdsr.2021.09.004.

  • Oogai Y, Nakata M. .  Small regulatory RNAs of oral streptococci and periodontal bacteria. .  Jpn. Dent. Sci. Rev.57   209 - 216   2021Small regulatory RNAs of oral streptococci and periodontal bacteria.Invited Reviewed

  • NAKATA Masanobu .  Temperature sensitive translational regulation by Streptococcus pyogenes .      2021Temperature sensitive translational regulation by Streptococcus pyogenesInvited Reviewed

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  • Nobuo Okahashi, Masanobu Nakata, Yujiro Hirose, Hirobumi Morisaki, Hideo Kataoka, Hirotaka Kuwata, Shigetada Kawabata .  Streptococcal H2O2 inhibits IgE-triggered degranulation of RBL-2H3 mast cell/basophil cell line by inducing cell death .  PLOS ONE15 ( 4 ) e0231101 - e0231101   2020.4

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    Publisher:Public Library of Science (PLoS)  

    DOI: 10.1371/journal.pone.0231101

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  • Nakata Masanobu, Sumitomo Tomoko, Patenge Nadja, Kreikemeyer Bernd, Kawabata Shigetada .  Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiency .  MOLECULAR MICROBIOLOGY113 ( 1 ) 173 - 189   2020Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiencyReviewed International coauthorship

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    DOI: 10.1111/mmi.14408

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  • Hirose Y, Yamaguchi M, Takemoto N, Miyoshi-Akiyama T, Sumitomo T, Nakata M, Ikebe T, Hanada T, Yamaguchi T, Kawahara R, Okuno R, Otsuka H, Matsumoto Y, Terashima Y, Kazawa Y, Nakanishi N, Uchida K, Akiyama Y, Iwabuchi K, Nakagawa C, Yamamoto K, Nizet V, Kawabata S. .  Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019. .  Infectious Microbes & Diseases 2 ( 4 ) 160 - 166   2020Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019.Reviewed International coauthorship

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  • Yamaguchi M, Takemura M, Higashi K, Goto K, Hirose Y, Sumitomo T, Nakata M, Uzawa N, Kawabata S. .  Role of BgaA as a Pneumococcal Virulence Factor Elucidated by Molecular Evolutionary Analysis. .  Frontiers in Microbiology11   582437   2020Role of BgaA as a Pneumococcal Virulence Factor Elucidated by Molecular Evolutionary Analysis. Reviewed

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  • Nakata Masanobu, Kawabata Shigetada .  Detection of fibronectin-binding proteins of Streptococcus pyogenes by ligand-blot analysis. .  Methods in Molecular Biology (published by Springer Nature)2136   181 - 190   2020Detection of fibronectin-binding proteins of Streptococcus pyogenes by ligand-blot analysis.Reviewed

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  • Kazuya Takeda, Shuhei Sakakibara, Kazuo Yamashita, Daisuke Motooka, Shota Nakamura, Marwa Ali El Hussien, Jun Katayama, Yohei Maeda, Masanobu Nakata, Shigeyuki Hamada, Daron M Standley, Masaki Hayama, Takashi Shikina, Hidenori Inohara, Hitoshi Kikutani .  Allergic conversion of protective mucosal immunity against nasal bacteria in patients with chronic rhinosinusitis with nasal polyposis. .  The Journal of allergy and clinical immunology143 ( 3 ) 1163 - 1175   2019Allergic conversion of protective mucosal immunity against nasal bacteria in patients with chronic rhinosinusitis with nasal polyposis.Invited Reviewed

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    BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is characterized by eosinophilic inflammation and polyposis at the nose and paranasal sinus and a high concentration of IgE in nasal polyps (NPs). The causative antigen and pathogenesis of CRSwNP remain unknown. OBJECTIVE: We aimed to identify reactive allergens of IgE antibodies produced locally in NPs of patients with CRSwNP. We also attempted to unravel the differentiation pathway of IgE-producing B cells in NPs. METHODS: IgE reactivity of patients with CRSwNP was investigated by characterizing single cell-derived mAbs. T-cell response against identified allergens was investigated in vitro. NP-infiltrating lymphocytes were characterized by using flow cytometry. Immunoglobulins expressed in NPs were analyzed by using high-throughput DNA sequencing for immunoglobulin. RESULTS: About 20% of isolated IgE antibodies derived from NP-residing plasmablasts specifically recognized surface determinants of nasal bacteria, such as Staphylococcus aureus, Streptococcus pyogenes, and Haemophilus influenzae. A TH2 response against S pyogenes was observed in patients with CRSwNP. Flow cytometric analysis revealed sizable germinal center B-like cell and plasmablast subsets expressing IgE on the cell surface in NPs. High-throughput DNA sequencing immunoglobulin analysis highlighted the clonal connectivity of IgE with IgG and IgA1. The Iε-Cα1 circle transcript was detected in NPs. CONCLUSIONS: In patients with CRSwNP, nasal bacteria-reactive B cells differentiate into IgE-producing B cells through IgG/IgA1-IgE class switching, suggesting that allergic conversion of the mucosal response against nasal bacteria underlies disease pathogenesis.

    DOI: 10.1016/j.jaci.2018.07.006

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  • Yamaguchi Masaya, Goto Kana, Hirose Yujiro, Yamaguchi Yuka, Sumitomo Tomoko, Nakata Masanobu, Nakano Kazuhiko, Kawabata Shigetada .  Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae .  COMMUNICATIONS BIOLOGY2   96   2019Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniaeInvited Reviewed

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    DOI: 10.1038/s42003-019-0340-7

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  • Yujiro Hirose, Masaya Yamaguchi, Daisuke Okuzaki, Daisuke Motooka, Hiroshi Hamamoto, Tomoki Hanada, Tomoko Sumitomo, Masanobu Nakata, Shigetada Kawabata .  Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis .  Applied and Environmental Microbiology85 ( 21 ) e01428-19   2019Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitisInvited Reviewed

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    © 2019 American Society for Microbiology. Streptococcus pyogenes is a major cause of necrotizing fasciitis, a lifethreatening subcutaneous soft-tissue infection. At the host infection site, the local environment and interactions between the host and bacteria have effects on bacterial gene expression profiles, while the gene expression pattern of S. pyogenes related to this disease remains unknown. In this study, we used a mouse model of necrotizing fasciitis and performed RNA-sequencing (RNA-seq) analysis of S. pyogenes M1T1 strain 5448 by isolating total RNA from infected hind limbs obtained at 24, 48, and 96 h postinfection. RNA-seq analysis results identified 483 bacterial genes whose expression was consistently altered in the infected hindlimbs compared to their expression under in vitro conditions. Genes showing consistent enrichment during infection included 306 encoding molecules involved in virulence, carbohydrate utilization, amino acid metabolism, trace-metal transport, and the vacuolar ATPase transport system. Surprisingly, drastic upregulation of 3 genes, encoding streptolysin S precursor (sagA), cysteine protease (speB), and secreted DNase (spd), was noted in the present mouse model (log2 fold change, > 6.0, > 9.4, and > 7.1, respectively). Conversely, the number of consistently downregulated genes was 177, including those associated with the oxidative stress response and cell division. These results suggest that in necrotizing fasciitis, S. pyogenes shows an altered metabolism, decreased cell proliferation, and upregulation of expression of major toxins. Our findings are considered to provide critical information for developing novel treatment strategies and vaccines for necrotizing fasciitis.

    DOI: 10.1128/AEM.01428-19

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  • Yamaguchi Masaya, Hirose Yujiro, Takemura Moe, Ono Masayuki, Sumitomo Tomoko, Nakata Masanobu, Terao Yutaka, Kawabata Shigetada .  Streptococcus pneumoniae Evades Host Cell Phagocytosis and Limits Host Mortality Through Its Cell Wall Anchoring Protein PfbA .  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY9   301   2019Streptococcus pneumoniae Evades Host Cell Phagocytosis and Limits Host Mortality Through Its Cell Wall Anchoring Protein PfbAInvited Reviewed

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    DOI: 10.3389/fcimb.2019.00301

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  • Hirose Y, Yamaguchi M, Goto K, Sumitomo T, Nakata M, Kawabata S .  Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis .  Virulence9 ( 1 ) 1576 - 1587   2018.9Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis

  • Katja Kriebel, Cathleen Hieke, Brigitte Müller-Hilke, Masanobu Nakata, Bernd Kreikemeyer .  Oral biofilms from symbiotic to pathogenic interactions and associated disease - Connection of periodontitis and rheumatic arthritis by peptidylarginine deiminase .  Frontiers in Microbiology9   53   2018.1Oral biofilms from symbiotic to pathogenic interactions and associated disease - Connection of periodontitis and rheumatic arthritis by peptidylarginine deiminase

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    Publisher:Frontiers Media S.A.  

    A wide range of bacterial species are harbored in the oral cavity, with the resulting complex network of interactions between the microbiome and host contributing to physiological as well as pathological conditions at both local and systemic levels. Bacterial communities inhabit the oral cavity as primary niches in a symbiotic manner and form dental biofilm in a stepwise process. However, excessive formation of biofilm in combination with a corresponding deregulated immune response leads to intra-oral diseases, such as dental caries, gingivitis, and periodontitis. Moreover, oral commensal bacteria, which are classified as so-called "pathobionts" according to a now widely accepted terminology, were recently shown to be present in extra-oral lesions with distinct bacterial species found to be involved in the onset of various pathophysiological conditions, including cancer, atherosclerosis, chronic infective endocarditis, and rheumatoid arthritis. The present review focuses on oral pathobionts as commensal and healthy members of oral biofilms that can turn into initiators of disease. We will shed light on the processes involved in dental biofilm formation and also provide an overview of the interactions of P. gingivalis, as one of the most prominent oral pathobionts, with host cells, including epithelial cells, phagocytes, and dental stem cells present in dental tissues. Notably, a previously unknown interaction of P. gingivalis bacteria with human stem cells that has impact on human immune response is discussed. In addition to this very specific interaction, the present review summarizes current knowledge regarding the immunomodulatory effect of P. gingivalis and other oral pathobionts, members of the oral microbiome, that pave the way for systemic and chronic diseases, thereby showing a link between periodontitis and rheumatoid arthritis.

    DOI: 10.3389/fmicb.2018.00053

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  • Tomoko Sumitomo, Yasushi Mori, Yuumi Nakamura, Mariko Honda-Ogawa, Seitaro Nakagawa, Masaya Yamaguchi, Hiroyuki Matsue, Yutaka Terao, Masanobu Nakata, Shigetada Kawabata .  Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection .  Frontiers in Cellular and Infection Microbiology8 ( 8 ) 10   2018Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infectionInvited Reviewed

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    Streptococcus pyogenes is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases. We identified streptococcal pyrogenic exotoxin B (SpeB) as a proteolytic factor that cleaves the extracellular domains of desmoglein 1 and 3. In an epicutaneous infection model, lesional skin infected with an speB deletion mutant were significantly smaller as compared to those caused by the wild-type strain. Furthermore, immunohistological analysis indicated cleavage of desmogleins that developed around the invasion site of the wild-type strain. In contrast, the speB mutant was preferentially found on the epidermis surface layer. Taken together, our findings provide evidence that SpeB-mediated degradation of desmosomes has a pathogenic role in development of S. pyogenes cutaneous infection.

    DOI: 10.3389/fcimb.2018.00010

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  • Chiaki Ota, Hirobumi Morisaki, Masanobu Nakata, Takafumi Arimoto, Haruka Fukamachi, Hideo Kataoka, Yoshiko Masuda, Noriyuki Suzuki, Takashi Miyazaki, Nobuo Okahashi, Hirotaka Kuwata .  Streptococcus sanguinis noncoding ciadependent small RNAs negatively regulate expression of type IV pilus retraction ATPase PilT and biofilm formation .  Infection and Immunity86 ( 3 ) e00894-17   2018Streptococcus sanguinis noncoding ciadependent small RNAs negatively regulate expression of type IV pilus retraction ATPase PilT and biofilm formationInvited Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Society for Microbiology  

    Small noncoding RNAs (sRNAs) have been identified as important regulators of gene expression in various cellular processes. cia-dependent small RNAs (csRNAs), a group of sRNAs that are controlled by the two-component regulatory system CiaRH, are widely conserved in streptococci, but their targets have been identified only in Streptococcus pneumoniae. Streptococcus sanguinis, a pioneer colonizer of teeth and one of the most predominant bacteria in the early oral biofilm, has been shown to have six csRNAs. Using computational target prediction and the luciferase reporter assay, we identified pilT, a constituent of the type IV pilus operon, as a negative regulatory target for one of the csRNAs, namely, csRNA1-1, in S. sanguinis. RNA-RNA electrophoretic mobility shift assay using a nucleotide exchange mutant of csRNA1-1 revealed that csRNA1-1 binds directly to pilT mRNA. In addition, csRNA1-1 and csRNA1-2, a putative gene duplication product of csRNA1-1 that is tandemly located in the S. sanguinis genome, negatively regulated S. sanguinis biofilm formation. These results suggest the involvement of csRNAs in the colonization step of S. sanguinis.

    DOI: 10.1128/IAI.00894-17

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  • Isenring Julia, Koehler Juliane, Nakata Masanobu, Frank Marcus, Jans Christoph, Renault Pierre, Danne Camille, Dramsi Shaynoor, Kreikemeyer Bernd, Oehmcke-Hecht Sonja .  Streptococcus gallolyticus subsp gallolyticus endocarditis isolate interferes with coagulation and activates the contact system .  VIRULENCE9 ( 1 ) 248 - 261   2018Streptococcus gallolyticus subsp gallolyticus endocarditis isolate interferes with coagulation and activates the contact systemInvited Reviewed International coauthorship

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    DOI: 10.1080/21505594.2017.1393600

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  • Nagase S, Matsue M, Mori Y, Honda-Ogawa M, Sugitani K, Sumitomo T, Nakata M, Kawabata S, Okamoto S. .  Comparison of antimicrobial spectrum and mechanisms of organic virgin coconut oil and lauric acid against bacteria. .  Journal of Wellness and Health Care41 ( 1 ) 87 - 95   2017Comparison of antimicrobial spectrum and mechanisms of organic virgin coconut oil and lauric acid against bacteria.Reviewed

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  • Ryuichi Sumioka, Masanobu Nakata, Nobuo Okahashi, Yixuan Li, Satoshi Wada, Masaya Yamaguchi, Tomoko Sumitomo, Mikako Hayashi, Shigetada Kawabata .  Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide .  PLOS ONE12 ( 2 ) e0172223   2017Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxideInvited Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:PUBLIC LIBRARY SCIENCE  

    Streptococcus is the dominant bacterial genus in the human oral cavity and a leading cause of infective endocarditis. Streptococcus sanguinis belongs to the mitis group of streptococci and produces hydrogen peroxide (H2O2) by the action of SpxB, a pyruvate oxidase. In this study, we investigated the involvement of SpxB in survival of S. sanguinis in human blood and whether bacterial H2O2 exhibits cytotoxicity against human neutrophils. Results of a bactericidal test with human whole blood revealed that the spxB mutation in S. sanguinis is detrimental to its survival in blood. When S. sanguinis strains were exposed to isolated neutrophils, the bacterial survival rate was significantly decreased by spxB deletion. Furthermore, human neutrophils exposed to the S. sanguinis wild-type strain, in contrast to those exposed to an spxB mutant strain, underwent cell death with chromatin de-condensation and release of web-like extracellular DNA, reflecting induction of neutrophil extracellular traps (NETs). Since reactive oxygen species-mediated NET induction requires citrullination of arginine residues in histone proteins and subsequent chromatin de-condensation, we examined citrullination levels of histone in infected neutrophils. It is important to note that the citrullinated histone H3 was readily detected in neutrophils infected with the wild-type strain, as compared to infection with the spxB mutant strain. Moreover, decomposition of streptococcal H2O2 with catalase reduced NET induction. These results suggest that H2O2 produced by S. sanguinis provokes cell death of neutrophils and NET formation, thus potentially affecting bacterial survival in the bloodstream.

    DOI: 10.1371/journal.pone.0172223

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  • Mariko Honda-Ogawa, Tomoko Sumitomo, Yasushi Mori, Dalia Talat Hamd, Taiji Ogawa, Masaya Yamaguchi, Masanobu Nakata, Shigetada Kawabata .  Streptococcus pyogenes Endopeptidase O Contributes to Evasion from Complement-mediated Bacteriolysis via Binding to Human Complement Factor C1q .  JOURNAL OF BIOLOGICAL CHEMISTRY292 ( 10 ) 4244 - 4254   2017Streptococcus pyogenes Endopeptidase O Contributes to Evasion from Complement-mediated Bacteriolysis via Binding to Human Complement Factor C1qInvited Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC  

    Streptococcus pyogenes secretes various virulence factors for evasion from complement-mediated bacteriolysis. However, full understanding of the molecules possessed by this organism that interact with complement C1q, an initiator of the classical complement pathway, remains elusive. In this study, we identified an endopeptidase of S. pyogenes, PepO, as an interacting molecule, and investigated its effects on complement immunity and pathogenesis. Enzyme-linked immunosorbent assay and surface plasmon resonance analysis findings revealed that S. pyogenes recombinant PepO bound to human C1q in a con-centration-dependent manner under physiological conditions. Sites of inflammation are known to have decreased pH levels, thus the effects of PepO on bacterial evasion from complement immunity was analyzed in a low pH condition. Notably, under low pH conditions, PepO exhibited a higher affinity for C1q as compared with IgG, and PepO inhibited the binding of IgG to C1q. In addition, pepO deletion rendered S. pyogenes more susceptible to the bacteriocidal activity of human serum. Also, observations of the morphological features of the pepO mutant strain (Delta pepO) showed damaged irregular surfaces as compared with the wild-type strain (WT). WT-infected tissues exhibited greater severity and lower complement activity as compared with those infected by Delta pepO in a mouse skin infection model. Furthermore, WT infection resulted in a larger accumulation of C1q than that with Delta pepO. Our results suggest that interaction of S. pyogenes PepO with C1q interferes with the complement pathway, which enables S. pyogenes to evade complement-mediated bacteriolysis under acidic conditions, such as seen in inflammatory sites.

    DOI: 10.1074/jbc.M116.749275

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  • Masaya Yamaguchi, Masanobu Nakata, Ryuichi Sumioka, Yujiro Hirose, Satoshi Wada, Yukihiro Akeda, Tomoko Sumitomo, Shigetada Kawabata .  Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems .  VIRULENCE8 ( 8 ) 1516 - 1524   2017Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systemsInvited Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:TAYLOR & FRANCIS INC  

    Streptococcus pneumoniae is a leading cause of bacterial meningitis. Here, we investigated whether pneumococcal paralogous zinc metalloproteases contribute to meningitis onset. Findings of codonbased phylogenetic analyses indicated 3 major clusters in the Zmp family; ZmpA, ZmpC, and ZmpB, with ZmpD as a subgroup. In vitro invasion assays of human brain microvascular endothelial cells (hBMECs) showed that deletion of the zmpC gene in S. pneumoniae strain TIGR4 significantly increased bacterial invasion into hBMECs, whereas deletion of either zmpA or zmpB had no effect. In a mouse meningitis model, the zmpC deletion mutant exhibited increased invasion of the brain and was associated with increased matrix metalloproteinase-9 in plasma and mortality as compared with the wild type. We concluded that ZmpC suppresses pneumococcal virulence by inhibiting bacterial invasion of the central nervous system. Furthermore, ZmpC illustrates the evolutional theory stating that gene duplication leads to acquisition of novel function to suppress excessive mortality.

    DOI: 10.1080/21505594.2017.1328333

    Web of Science

    PubMed

  • Okahashi N, Nakata M, Kuwata H, Kawabata S. .  Streptococcus oralis induces lysosomal impairment of macrophages via bacterial hydrogen peroxide. .  Infection and Immunity84 ( 7 ) 2042 - 2050   2016Streptococcus oralis induces lysosomal impairment of macrophages via bacterial hydrogen peroxide. Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.00134-16

  • Yamaguchi M, Hirose Y, Nakata M, Uchiyama S, Yamaguchi Y, Goto K, Sumitomo T, Lewis A, Kawabata S. .  Evolutionary inactivation of a sialidase in group B Streptococcus. .  Scientific Reports6   28852   2016Evolutionary inactivation of a sialidase in group B Streptococcus.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep28852

  • Sumitomo T, Nakata M, Higashino M, Yamaguchi M, and Kawabata S. .  Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions. .  Scientific Reports6   20069   2016Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep20069

  • Morita C, Sumioka R, Nakata M, Okahashi N, Wada S, Yamashiro T, Hayashi M, Hamada S, Sumitomo T, Kawabata S. .  Cell wall-anchored nuclease of Streptococcus sanguinis contributes to escape from neutrophil extracellular trap-mediated bacteriocidal activity. .  PLoS One9 ( 8 ) e103125   2014Cell wall-anchored nuclease of Streptococcus sanguinis contributes to escape from neutrophil extracellular trap-mediated bacteriocidal activity.Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0103125

  • Okahashi N, Sumitomo T, Nakata M, Sakurai A, Kuwata H, Kawabata S. .  Hydrogen peroxide contributes to the epithelial cell death induced by the oral mitis group of streptococci. .  PLoS One9 ( 1 ) e88136   2014Hydrogen peroxide contributes to the epithelial cell death induced by the oral mitis group of streptococci.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0088136

  • Honda-Ogawa M, Ogawa T, Terao Y, Sumitomo T, Nakata M, Ikebe K, Maeda Y, Kawabata S. .  Cysteine proteinase from Streptococcus pyogenes enables evasion of innate immunity via degradation of complement factors. .  Journal of Biological Chemistry288 ( 22 ) 15854 - 15864   2013Cysteine proteinase from Streptococcus pyogenes enables evasion of innate immunity via degradation of complement factors.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M113.469106

  • Okahashi N, Nakata M, Sumitomo T, Terao Y, Kawabata S. .  Hydrogen peroxide produced by oral streptococci induces macrophage cell death. .  PLoS One8 ( 5 ) e62563   2013Hydrogen peroxide produced by oral streptococci induces macrophage cell death.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0062563

  • Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S. .  Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation. .  Journal of Biological Chemistry288 ( 19 ) 13317 - 13324   2013Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M113.459875

  • Kimura KR, Nakata M, Sumitomo T, Kreikemeyer B, Podbielski A, Terao Y, Kawabata S. .  Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus pyogenes. .  Journal of Bacteriology194 ( 4 ) 804 - 812   2012Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus pyogenes. Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/JB.06283-11

  • Sumitomo T, Nakata M, Yamaguchi M, Terao Y, Kawabata S. .  S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells. .  Journal of Medical Microbiology61 ( Pt1 ) 101 - 108   2012S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1099/jmm.0.033688-0

  • Nakata M, Kimura KR, Sumitomo T, Wada S, Sugauchi A, Oiki E, Higashino M, Kreikemeyer B, Podbielski A, Okahashi N, Hamada S, Isoda R, Terao Y, Kawabata S. .  Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenes. .  Journal of Biological Chemistry286 ( 43 ) 37566 - 37577   2011Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenes. Reviewed

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    DOI: 10.1074/jbc.M111.239780

  • Sumitomo T, Nakata M, Higashino M, Jin Y, Terao Y, Fujinaga Y, Kawabata S. .  Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier. .  Journal of Biological Chemistry286 ( 4 ) 2750 - 2761   2011Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M110.171504

  • Okahashi N, Nakata M, Terao Y, Isoda R, Sakurai A, Sumitomo T, Yamaguchi M, Kimura RK, Oiki E, Kawabata S, Ooshima T. .  Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. .  Microbial Pathogenesis50 ( 3-4 ) 148 - 154   2011Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.micpath.2011.01.005

  • Okahashi N, Okinaga T, Sakurai A, Terao Y, Nakata M, Nakashima K, Shintani S, Kawabata S, Ooshima T, Nishihara T. .  Streptococcus sanguinis induces foam cell formation and cell death of macrophages in association with production of reactive oxygen species. .  FEMS Microbiology Letters323 ( 2 ) 164 - 170   2011Streptococcus sanguinis induces foam cell formation and cell death of macrophages in association with production of reactive oxygen species. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1574-6968.2011.02375.x

  • Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T. .  Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. .  Biochemical and Biophysical Research Communications391 ( 2 ) 1192 - 1196   2010Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2009.12.029

  • Nakata M, Köller T, Moritz K, Ribardo D, Jonas L, McIver KS, Sumitomo T, Terao Y, Kawabata S, Podbielski A, Kreikemeyer B. .  Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. .  Infection and Immunity77 ( 1 ) 32 - 44   2009Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49.Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.00772-08

  • Panchaud A, Guy L, Collyn F, Haenni M, Nakata M, Podbielski A, Moreillon P, Roten CA. .  M-protein and other intrinsic virulence factors of Streptococcus pyogenes are encoded on an ancient pathogenicity island. .  BMC Genomics10   198   2009M-protein and other intrinsic virulence factors of Streptococcus pyogenes are encoded on an ancient pathogenicity island.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1471-2164-10-198

  • Köller T, Nelson D, Nakata M, Kreutzer M, Fischetti VA, Glocker MO, Podbielski A, Kreikemeyer B. .  PlyC, a novel bacteriophage lysin for compartment-dependent proteomics of group A streptococci. .  Proteomics8 ( 1 ) 140 - 148   2008PlyC, a novel bacteriophage lysin for compartment-dependent proteomics of group A streptococci.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/pmic.200700001

  • Klenk M, Nakata M, Podbielski A, Skupin B, Schroten H, Kreikemeyer B. .  Streptococcus pyogenes serotype-dependent and independent changes in infected HEp-2 epithelial cells. .  ISME Journal1 ( 8 ) 678 - 692   2007Streptococcus pyogenes serotype-dependent and independent changes in infected HEp-2 epithelial cells.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ismej.2007.54

  • Kreikemeyer B, Nakata M, Köller T, Hildisch H, Kourakos V, Standar K, Kawabata S, Glocker MO, Podbielski A. .  The Streptococcus pyogenes serotype M49 Nra-Ralp3 transcriptional regulatory network and its control on virulence factor expression from the novel ERES pathogenicity region. .  Infection and Immunity75 ( 12 ) 5698 - 5710   2007The Streptococcus pyogenes serotype M49 Nra-Ralp3 transcriptional regulatory network and its control on virulence factor expression from the novel ERES pathogenicity region.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/IAI.00175-07

  • Klenk M, Koczan D, Guthke R, Nakata M, Thiesen HJ, Podbielski A, Kreikemeyer B. .  Global epithelial cell transcriptional responses reveal Streptococcus pyogenes Fas regulator activity association with bacterial aggressiveness. .  Cellular Microbiology7 ( 9 ) 1237 - 1250   2005Global epithelial cell transcriptional responses reveal Streptococcus pyogenes Fas regulator activity association with bacterial aggressiveness.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1462-5822.2005.00548.x

  • Kreikemeyer B, Nakata M, Oehmcke S, Gschwendtner C, Normann J, Podbielski A. .  Streptococcus pyogenes collagen type I-binding Cpa surface protein. Expression profile, binding characteristics, biological functions, and potential clinical impact. .  Journal of Biological Chemistry280 ( 39 ) 33228 - 33239   2005Streptococcus pyogenes collagen type I-binding Cpa surface protein. Expression profile, binding characteristics, biological functions, and potential clinical impact. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M502896200

  • Nakata M, Podbielski A, Kreikemeyer B. .  MsmR, a specific positive regulator of the Streptococcus pyogenes FCT pathogenicity region and cytolysin-mediated translocation system genes. .  Molecular Microbiology57 ( 3 ) 786 - 803   2005MsmR, a specific positive regulator of the Streptococcus pyogenes FCT pathogenicity region and cytolysin-mediated translocation system genes.Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2958.2005.04730.x

  • Nakagawa I, Amano A, Mizushima N, Yamamoto A, Yamaguchi H, Kamimoto T, Nara A, Funao J, Nakata M, Tsuda K, Hamada S, Yoshimori T. .  Autophagy defends cells against invading group A Streptococcus. .  Science306 ( 5698 ) 1037 - 1040   2004Autophagy defends cells against invading group A Streptococcus.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.1103966

  • Nakagawa I, Nakata M, Kawabata S, Hamada S. .  Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells. .  Cellular Microbiology6 ( 10 ) 939 - 952   2004Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1462-5822.2004.00412.x

  • Kreikemeyer B, Oehmcke S, Nakata M, Hoffrogge R, Podbielski A. .  Streptococcus pyogenes fibronectin-binding protein F2: expression profile, binding characteristics, and impact on eukaryotic cell interactions. .  Journal of Biological Chemistry279 ( 16 ) 15850 - 15859   2004Streptococcus pyogenes fibronectin-binding protein F2: expression profile, binding characteristics, and impact on eukaryotic cell interactions. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M313613200

  • Nakagawa I, Kurokawa K, Yamashita A, Nakata M, Tomiyasu Y, Okahashi N, Kawabata S, Yamazaki K, Shiba T, Yasunaga T, Hayashi H, Hattori M, Hamada S. .  Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution. .  Genome Research13 ( 6A ) 1042 - 1055   2003Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1101/gr.1096703

  • Terao Y, Kawabata S, Nakata M, Nakagawa I, Hamada S. .  Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients. .  Journal of Biological Chemistry277 ( 49 ) 47428 - 47435   2002Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M209133200

  • Nakagawa I, Nakata M, Yamamura T, Wakisaka S, Kawabata S, Hamada S. .  Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice. .  Microbial Pathogenesis33 ( 2 ) 63 - 72   2002Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/mpat.2002.0518

  • Nakagawa I, Nakata M, Kawabata S, Hamada S. .  Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells .  Cellular Microbiology3 ( 6 ) 395 - 405   2001Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cellsReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1462-5822.2001.00122.x

  • Nakagawa I, Nakata M, Kawabata S, Hamada S. .  Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells. .  Molecular Microbiology33 ( 6 ) 1190 - 1199   1999Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1365-2958.1999.01564.x

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Books

  • Group A Streptococcus: Methods and Protocols

    Nakata M, Kawabata S.( Role: Joint author ,  Detection of fibronectin-binding proteins of Streptococcus pyogenes by ligand-blot analysis.)

    Springer Nature  2020 

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    Total pages:10   Responsible for pages:181-190   Language:English Book type:Scholarly book

  • 口腔微生物学・免疫学 第5版 Reviewed

    中田匡宣( Role: Joint author ,  微生物の遺伝学,微生物遺伝子の変化,微生物遺伝子の応用)

    医歯薬出版株式会社  2021.12 

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    Total pages:17   Language:Japanese

  • 口腔微生物学・免疫学 第4版

    中田匡宣,川端重忠 他( Role: Joint author ,  微生物の遺伝学,微生物遺伝子の変化,微生物遺伝子の応用)

    医歯薬出版株式会社  2016 

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    Total pages:17   Responsible for pages:32〜48   Language:Japanese Book type:Scholarly book

  • 病原性レンサ球菌の病原因子の機能解析.

    寺尾豊, 中田匡宣, 住友倫子, 磯田竜太朗, 川端重忠( Role: Joint author)

    大阪大学出版会  2008.3 

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    Book type:General book, introductory book for general audience

  • 生命歯科医学のカッティング・エッジ

    寺尾豊,住友倫子,中田匡宣,磯田竜太朗,川端重忠 他( Role: Contributor)

    大阪大学出版会  2008 

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    Total pages:11   Responsible for pages:68〜78   Language:Japanese Book type:Scholarly book

  • The 9th International Conference on Shallow-Level Centers in Semiconductors : proceedings of the Yamada Conference LIV, held in Awaji island, Hyogo, Japan, 24-27 September 2000

    International Conference on Shallow-Level Centers in Semiconductors

    Elsevier Science  2001 

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    Language:English

    CiNii Books

  • Streptococci and Streptococcal Diseases edited by Martin DR, and Tagg JR.Effects of receptor-globulins on invasive group A streptococcal infection.

    Nakagawa I, Kimura RK, Nakata M, Kuwata H, Kawabata S, Hamada S( Role: Joint author)

    Securacopy Press  2000.10 

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    Book type:Scholarly book

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MISC

  • 化膿レンサ球菌による温度感受性の翻訳制御

    中田 匡宣

    南九州歯学会雑誌   3 ( 1 )   1 - 7   2022.9

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    Language:Japanese   Publisher:南九州歯学会  

    化膿レンサ球菌(Streptococcus pyogenes)は主に上気道や皮膚に限局性の化膿性疾患を惹き起こす。また,免疫性続発症や劇症型溶血性レンサ球菌感染症の原因になる。化膿レンサ球菌が宿主に定着し,多様な疾患を惹き起こすためには,環境条件に応じて分泌タンパク質の発現を調節する必要がある。化膿レンサ球菌の線毛は宿主組織への付着因子であるとともに,バイオフィルム形成や宿主免疫の回避に寄与することが報告されている。また、線毛のメジャーサブユニットの抗原性はTタイピングに用いられてきた。本稿では,化膿レンサ球菌の特定のサブセットから温度依存性に線毛が産生される機構を紹介する。この現象は,線毛遺伝子に対する転写因子であるNraの温度に依存する転写後翻訳制御に起因する。すなわち,nra mRNAの翻訳領域に位置する推定ステムループ構造がサーモセンサーとして機能し,温度感受性にnra mRNAの翻訳と線毛の産生を誘導する。この現象の発見により,化膿レンサ球菌の組織指向性と線毛発現様式の関連とともに,mRNAによる温度感知と翻訳制御が化膿レンサ球菌の宿主環境への適応に重要であることが示唆された。(著者抄録)

  • Secondary streptococcal infection following influenza(タイトル和訳中)

    Okahashi Nobuo, Sumitomo Tomoko, Nakata Masanobu, Kawabata Shigetada

    Microbiology and Immunology   66 ( 6 )   253 - 263   2022.6

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    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

  • Small regulatory RNAs of oral streptococci and periodontal bacteria(タイトル和訳中)

    Oogai Yuichi, Nakata Masanobu

    The Japanese Dental Science Review   57   209 - 216   2021.11

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    Language:English   Publisher:日本歯科医学会  

  • Genetics, Structure, and Function of Group A Streptococcal Pili Reviewed

    Nakata, M., Kreikemeyer, B.

    Frontiers in Microbiology   2021

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Investigation of factors contributing to the invasiveness of Streptococcus pyogenes emm 89

    広瀬雄二郎, 山口雅也, 秋山徹, 竹本訓彦, 奥野ルミ, 山口貴弘, 大塚仁, 住友倫子, 中田匡宣, 川端重忠

    日本細菌学雑誌(Web)   75 ( 1 )   2020

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  • Oral biofilms from symbiotic to pathogenic interactions and associated disease – Connection of Periodontitis and Rheumatic arthritis by peptidylarginine deiminase. Reviewed

    Kriebel K, Hieke C, Müller-Hilke B, Nakata M, Kreikemeyer B.

    Frontiers in Microbiology   2018

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions

    Tomoko Sumitomo, Masanobu Nakata, Miharu Higashino, Masaya Yamaguchi, Shigetada Kawabata

    SCIENTIFIC REPORTS   7   46388   2017.6

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    Publisher:NATURE PUBLISHING GROUP  

    DOI: 10.1038/srep46388

    Web of Science

    PubMed

  • 【改めて考えるレンサ球菌感染症】レンサ球菌の病原因子

    中田 匡宣, 川端 重忠

    化学療法の領域   33 ( 6 )   1183 - 1190   2017.5

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    Publisher:(株)医薬ジャーナル社  

    化膿レンサ球菌(Streptococcus pyogenes),肺炎球菌(Streptococcus pneumoniae)およびB群レンサ球菌(Streptococcus agalactiae)は高い罹患率と死亡率をもたらす病原性レンサ球菌である。近年,抗菌薬耐性菌の増加により病原性レンサ球菌に対するワクチンの開発や改良が望まれている。菌体の定着やヒト免疫機構からの回避に寄与する病原因子群は感染成立と病態形成に必須であり,ワクチン抗原の候補となり得る。近縁種に共通して認められる病原因子も数多く存在し,レンサ球菌に普遍的な病原性を与えている。(著者抄録)

  • 【改めて考えるレンサ球菌感染症】レンサ球菌の病原因子

    中田 匡宣, 川端 重忠

    化学療法の領域   33 ( 6 )   1183 - 1190   2017.5

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    Publisher:(株)医薬ジャーナル社  

    化膿レンサ球菌(Streptococcus pyogenes),肺炎球菌(Streptococcus pneumoniae)およびB群レンサ球菌(Streptococcus agalactiae)は高い罹患率と死亡率をもたらす病原性レンサ球菌である。近年,抗菌薬耐性菌の増加により病原性レンサ球菌に対するワクチンの開発や改良が望まれている。菌体の定着やヒト免疫機構からの回避に寄与する病原因子群は感染成立と病態形成に必須であり,ワクチン抗原の候補となり得る。近縁種に共通して認められる病原因子も数多く存在し,レンサ球菌に普遍的な病原性を与えている。(著者抄録)

  • レンサ球菌感染症に対する免疫療法の可能性.

    中田匡宣, 川端重忠.

    化学療法の領域   2017

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • 肺炎球菌と現行ワクチン.

    中田匡宣, 川端重忠.

    日本歯科医師会雑誌   2015

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

  • 病原性レンサ球菌の二成分制御系シグナル伝達機構.

    中田匡宣, 川端重忠.

    化学療法の領域   2013

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • 口腔内微生物の網羅的検出.

    中田匡宣, 川端重忠.

    歯界展望   2010

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • A群レンサ球菌の病原性発現に関する分子機構.

    中田匡宣, 寺尾豊,川端重忠.

    感染・炎症・免疫   2008

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • A群レンサ球菌 Pilus 発現機構の解析

    中田 匡宣, 川端 重忠

    日本細菌学雑誌   62 ( 1 )   83 - 83   2007.2

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    Language:Japanese  

    CiNii Books

  • レンサ球菌感染症に対する免疫療法の可能性.

    中田匡宣,寺尾豊,川端重忠.

    炎症と免疫   2007

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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Presentations

  • Higashi K, Yamaguchi M, Takebe K, Nakata M, Sumitomo T, Suzuki M, Varki A, Nizet V, Kawabata S.   Hyaluronidase in Streptococcus pyogenes – analysis based on structural biology and molecular phylogenetics.   International coauthorship International conference

    Society for Glycobiology 2023 Annal meeting  2023.11 

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    Event date: 2023.11

  • 田中 友三佳,大貝 悠一,松本 愛理,中田 匡宣.   Fusobacterium nucleatumが Fap2を介してAggregatibacter actinomycetemcomitansと共凝集する機構の解析.  

    第65回歯科基礎医学会学術大会  2023.9 

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    Event date: 2023.9

  • 中田 匡宣,窪田 星子,広瀬 雄二郎,山口 雅也,住友倫子,川端重忠.   化膿レンサ球菌のRNase Yによる線毛産生量の調節.  

    第65回歯科基礎医学会学術大会  2023.9 

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    Event date: 2023.9

    Language:Japanese  

  • 武部 克希,鈴木 守,東 孝太郎,山口 雅也,住友 倫子,川端 重忠,中田 匡宣.   Streptococcus sanguinis が産生する線毛タンパク質の X線結晶構造解析.  

    第65回 歯科基礎医学会学術大会  2023.9 

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    Event date: 2023.9

  • 松本愛理,大貝悠一,田端厚之,住友倫子,中田匡宣.   ミティス群レンサ球菌が産生する細胞外小胞の作用特性の解明.  

    九州微生物研究フォーラム2023  2023.9 

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    Event date: 2023.9

  • 赤松 由佳子, 住友倫子, 高原悠樹, 広瀬雄二郎, 山口雅也, 中田匡宣, 秋山茂久, 明石満, 川端重忠.   交互積層細胞コーティング法を用いた三次元肺組織モデルの構築と感染モデルへの応用.  

    第75回 日本細菌学会関西支部総会  2022.11 

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    Event date: 2022.11

  • 赤松 由佳子, 住友 倫子, 高原 悠樹, 山口 雅也, 中田 匡宣, 明石 満, 川端 重忠.   肺炎球菌を感染させた三次元肺組織モデルにおける上皮バリアの機能障害と炎症応答の解析.  

    第64回 歯科基礎医学会学術大会  2022.9 

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    Event date: 2022.9

    Venue:徳島市  

  • 高原 悠樹, 住友 倫子, 河野 正充, 赤松 由佳子, 山口 雅也, 中田 匡宣, 保富 宗城, 川端 重忠.   肺炎球菌のニューモライシン依存的な鼻粘膜上皮バリア傷害と脳伝播機構の解析.  

    第52回 レンサ球菌研究会  2022.7 

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    Event date: 2022.7

  • 高原悠樹,住友倫子,河野正充,山口雅也,中田匡宣,保富宗城,川端重忠.   肺炎球菌のニューモライシンによる鼻粘膜上皮バリアの傷害と脳伝播機構の解析  

    第95回日本細菌学会総会  2022.3 

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    Event date: 2022.3

  • Nasal epithelial barrier dysfunction involved in non-hematogenous pneumococcal dissemination to brain tissue   International conference

    2021.12 

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    Event date: 2021.12

    Language:English  

  • 高原悠樹, 住友倫子, 山口雅也, 中田匡宣, 川端重忠   肺炎球菌のニューモライシン依存的な鼻粘膜バリア傷害と脳への伝播機構の関連  

    第63回歯科基礎医学会学術大会  2021.10 

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    Event date: 2021.10

  • 中田匡宣   化膿レンサ球菌におけるサーモセンサーの発見   Invited

    第3回南九州歯学会学術大会  2021  第3回南九州歯学会学術大会

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • 大貝悠一, 藤田愛弓, 中田匡宣, 小松澤均   Aggregatibacter actinomycetemcomitansは血清培養時に共凝集性を促進する.  

    第94回 日本細菌学会総会  2021.3 

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    Event date: 2021.3

  • 中田匡宣   Thermosensitive pilus production by Streptococcus pyogenes via mRNA thermosensor.   Invited

    第93回 日本細菌学会総会 

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    Event date: 2020.2

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  • 中田匡宣, 住友倫子, 川端重忠.   温度感受性転写因子の翻訳効率に依存する化膿レンサ球菌の線毛発現.  

    第61回 歯科基礎医学会学術大会 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Poster presentation  

  • Sumitomo T, Hamd DT, Honda-Ogawa M, Mori Y, Yamaguchi M, Nakata M, Kawabata S.   Two-component regulatory system TCS08 contributes to pathogenesis in pneumococcal pneumonia.   International conference

    ASM Microbe 2019 

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    Event date: 2019.6

    Language:English   Presentation type:Poster presentation  

  • 中田匡宣, 住友倫子, 川端重忠.   化膿レンサ球菌による温度依存性の線毛産生.  

    第92回 日本細菌学会総会 

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    Event date: 2019.4

    Language:Japanese   Presentation type:Poster presentation  

  • Yamaguchi M, Goto K, Hirose Y, Yamaguchi Y, Sumitomo T, Nakata M, Kawabata S.   Identification of novel pneumococcal virulence factor CbpJ by molecular evolutional analysis.   International conference

    Gordon Research Conference 

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    Event date: 2018.8

    Language:English   Presentation type:Oral presentation (general)  

  • Hirose Y, Yamaguchi M, Goto K, Sumitomo T, Nakata M, Kawabata S.   Pneumococcal Ccs4 facilitates its invasion into brain tissue and develops meningitis.   International conference

    118th General Meeting of American Society for Microbiology 

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    Event date: 2018.6

    Language:English   Presentation type:Poster presentation  

  • Yamaguchi M, Hirose Y, GotoK, Sumitomo T, Nakata M, Kawabata S.   Streptococcus pneumoniae evades host innate immunity through parallel β-helix protein PfbA.   International conference

    20th Lancefield International Symposium on Streptococci and Streptococal Disease. 

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    Event date: 2017.10

    Language:English   Presentation type:Poster presentation  

  • 中田匡宣, 住友倫子, 川端重忠.   化膿レンサ球菌における温度感受性の線毛発現機構.  

    第59回 歯科基礎医学会学術大会 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Sumitomo T, Mori Y, Nakamura Y, Honda-Ogawa M, Yamaguchi M, Terao Y, Nakata M, Kawabata S.   Streptococcal cysteine protease-mediated cleavage of desmogleins contributes to development of cutaneous infection.   International conference

    IUMS2017 

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    Event date: 2017.7

    Language:English   Presentation type:Poster presentation  

  • 中田匡宣, 住友倫子, 山口雅也, 川端重忠.   化膿レンサ球菌の線毛発現機構.  

    第37回 近畿腸管微生物研究会 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Honda M, Sumitomo T, Mori Y, Yamaguchi M, Nakata M, Kawabata S.   Involvement of Group A streptococcal endopeptidase O in evasion from complement-mediated bacteriolysis via binding to complement C1q.   International conference

    13th Korea-Japan International Symposium on Microbiology 

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    Event date: 2016.5

    Language:English   Presentation type:Poster presentation  

  • 中田匡宣,住友倫子,山口雅也,川端重忠.   培養温度の変化が肺炎球菌の血中での生存に及ぼす影響.  

    第89回 日本細菌学会総会 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Poster presentation  

  • Sumitomo T, Nakata M, Yamaguchi M, Kawabata S.   Group A Streptococcus penetrates across an epithelial barrier via tricellular tight junctions.   International conference

    115th General Meeting of American Society for Microbiology 

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    Event date: 2015.5 - 2015.6

    Language:English   Presentation type:Poster presentation  

  • 中田匡宣,住友倫子,寺尾豊,川端重忠.   Transcriptional regulation of FCT type 1 pili in serotype M6 Streptococcus pyogenes.  

    第88回日本細菌学会総会 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Poster presentation  

  • Yamaguchi M, Yamaguchi Y, Nakata M, Henningham A, Olson J, Dahesh S, Cole J, Kawabata S, Varki A, Nizet V.   Enzymatically active extracellular hyaluronidase (HylA) of group A Streptococcus promotes intracellular survival and virulence.   International conference

    SFG and JSCR2014 Joint Annual Meeting 

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    Event date: 2014.11

    Language:English   Presentation type:Poster presentation  

  • Morita C, Nakata M, Sumioka R, Okahashi N, Hamada S, Sumitomo T, Kawabata S.   Role of Streptococcus sanguinis cell wall-anchored nuclease.   International conference

    19th Lancefield International Symposium on Streptococci and Streptococal Disease 

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    Event date: 2014.11

    Language:English   Presentation type:Poster presentation  

  • 中田匡宣,住友倫子,川端重忠.   Streptococcus sanguinisが産生する菌体表層ヌクレアーゼの解析.  

    第34回 近畿腸管微生物研究会 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 中田匡宣,住友倫子,浜田茂幸,川端重忠.   Regulation of pilus gene expression in FCT type 3 strain of Streptococcus pyogenes.  

    第87回 日本細菌学会総会 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  • Nakata M, Kawabata S.   Mode of expression and assembly mechanism of Group A Streptococcal pili.   Invited International conference

    12th Awaji International Forum on Infection and Immunity 

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    Event date: 2013.9

    Language:English   Presentation type:Oral presentation (invited, special)  

  • Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S.   Group A streptococcal pyrogenic exotoxin B cleaves epithelial junctions and contributes to bacterial translocation.  

    113th General Meeting of American Society for Microbiology 

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    Event date: 2013.5

    Language:English   Presentation type:Poster presentation  

  • Nakata M, Sumitomo T, Kawabata S.   Assembly mechanism of T6 pili and its involvement in biofilm formation.   International conference

    GAS Infections 2013 

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    Event date: 2013.3

    Language:English   Presentation type:Symposium, workshop panel (public)  

  • 中田匡宣,住友倫子,寺尾豊,浜田茂幸,川端重忠.   Cell wall anchoring mechanism of FCT region type 3 pili in Streptococcus pyogenes.  

    第86回 日本細菌学会総会 

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    Event date: 2013.3

    Language:Japanese   Presentation type:Poster presentation  

  • Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S.   Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation.   International conference

    11th Korea-Japan International Symposium on Microbiology 

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    Event date: 2012.9

    Language:English   Presentation type:Poster presentation  

  • 中田匡宣,住友倫子,寺尾豊,川端重忠.   A群レンサ球菌が産生するT6線毛の発現機構の解析.  

    第32回 近畿腸管微生物研究会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 中田匡宣,住友倫子,東野美晴,岡橋暢夫,浜田茂幸,寺尾豊,川端重忠.   Assembly mechanism of T6 pili in serotype M6 Streptococcus pyogenes.  

    第85回 日本細菌学会総会 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Poster presentation  

  • Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S.   Streptococcal pyrogenic exotoxin B contributes to cleavage of epithelial junctions.   International conference

    XVIII Lancefield International Symposium 

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    Event date: 2011.9

    Language:English   Presentation type:Poster presentation  

  • 中田匡宣,木村敬次Richard,住友倫子,寺尾豊,川端重忠.   T6線毛の形成機構とバイオフィルム形成への関与.  

    第20回 Lancefieldレンサ球菌研究会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Sumitomo T, Nakata M, Terao Y, Kawabata S.   Streptolysin S contributes to group A streptococcal paracellular translocation across epithelial cells.   International conference

    10th Awaji International Forum on Infection and Immunity 

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    Event date: 2010.9

    Language:English   Presentation type:Poster presentation  

  • 中田匡宣,住友倫子,磯田竜太朗,寺尾豊,川端重忠.   A群レンサ球菌が産生する線毛の細胞壁架橋機構の解析.  

    第83回 日本細菌学会総会 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Poster presentation  

  • Sumitomo T, Nakata M, Terao Y, Kawabata S.   Group A Streptococci translocates across epithelial barrier via intercellular junction cleavage.   International conference

    109th General Meeting of American Society for Microbiology 

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    Event date: 2009.5

    Language:English   Presentation type:Poster presentation  

  • Isoda R, Terao Y, Nakata M, Sumitomo T, Kawabata S.   Neonatal exposure induced commensal-like immune-response against Aggregatibacter actinomycetemcomitans in mice.   International conference

    87th General Session & Exhibition of the International Association for Dental Research 

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    Event date: 2009.4

    Language:English   Presentation type:Symposium, workshop panel (public)  

  • Nakata M, Fiedler T, Koller T, Stander K, Kawabata S, Podbielski A, Kreikemeyer B.   The Nra-Ralp3 transcriptional regulatory network of Streptococcus pyogenes serotype M49: control of the novel ERES pathogenicity region.   International conference

    17th Lancefield International Symposium on Streptococci & Streptococcal Diseases 

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    Event date: 2008.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

  • Nakata M, Ribardo DA, McIver KS, Podbielski A, Kreikemeyer B, Kawabata S.   Role of the Streptococcus pyogenes FCT-region components in pilus assembly and virulence.   International conference

    7th Awaji International Forum on Infection and Immunity 

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    Event date: 2007.9

    Language:English   Presentation type:Poster presentation  

  • Nakata M, Ribardo DA, McIver KS, Kawabata S, Podbielski A, Kreikemeyer B.   Role of Streptococcus pyogenes FCT-region sortase and other components in pilus assembly and virulence.   International conference

    107th General Meeting of American Society for Microbiology 

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    Event date: 2007.5

    Language:English   Presentation type:Poster presentation  

  • Nakata M, Podbielski A, Kreikemeyer B.   Analysis of a genomic island encoding important virulence factors and transcriptional regulators.   International conference

    7th ASM Conference on Streptococcal Genetics 

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    Event date: 2006.6

    Language:English   Presentation type:Poster presentation  

  • Nakagawa I, Nakata M, Sakurai A, Kawabata S, Hamada S.   Rac1-mediated invasion triggers apoptotic cell death in Streptococcus pyogenes infected epithelial cells by inducing reactive oxygen subspecies.   International conference

    105th General Meeting of American Society for Microbiology 

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    Event date: 2005.6

    Language:English   Presentation type:Poster presentation  

  • Nakata M, Kreikemeyer B, Podbielski A.   Analysis of differential recognition of surface proteins by sortase A and C2 in serotype M49 Streptococcus pyogenes.   International conference

    2nd Joint Conference of the German Society for Hygiene and Microbiology (DGHM) and the Association for General and Applied Microbiology (VAAM) 

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    Event date: 2005.2

    Language:English   Presentation type:Poster presentation  

  • Nakata M, Podbielski A, Kreikemeyer B.   MsmR, a specific positive regulator of the Streptococcus pyogenes FCT pathogenicity region and cytolysin-mediated translocation system genes.   International conference

    2nd Joint Conference of the German Society for Hygiene and Microbiology (DGHM) and the Association for General and Applied Microbiology (VAAM) 

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    Event date: 2005.2

    Language:English   Presentation type:Symposium, workshop panel (public)  

  • Nakata M, Kreikemeyer B, Podbielski A.   The functional analysis of proteins encoded by the Group A Streptococcus pyogenes FCT region.   International conference

    Conference program for the specialized group “Microbial Pathogenicity” 

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    Event date: 2004.5

    Language:English   Presentation type:Oral presentation (general)  

  • Nakata M, Kreikemeyer B, Podbielski A.   Functional characterization of the MsmR positive regulator for fibronectin-binding by Streptococcus pyogenes.   International conference

    56th conference of the German Society for Hygiene and Microbiology (DGHM) 

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    Event date: 2004.2

    Language:English   Presentation type:Poster presentation  

  • Nakata M, Kreikemeyer B, Podbielski A.   Functional analysis of a potential polypeptide processing complex and virulence factors encoded by the Streptococcus pyogenes FCT pathogenicity region.   International conference

    56th conference of the German Society for Hygiene and Microbiology (DGHM) 

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    Event date: 2004.2

    Language:English   Presentation type:Poster presentation  

  • Nakata M, Nakagawa I, Kawabata S, Hamada S.   Overexpression of Bcl-2 can protect S. pyogenes-infected epithelial cells from apoptotic cell death.   International conference

    15th Lancefield International Symposium on Streptococci and Streptococcal Diseases 

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    Event date: 2002.10

    Language:English   Presentation type:Poster presentation  

  • Nakata M, Nakagawa I, Kawabata S, Hamada S.   Overexpression of Bcl-2 can protect Streptococcus pyogenes infected epithelial cells from apoptotic cell death.   International conference

    101st General Meeting of American Society for Microbiology 

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    Event date: 2001.5

    Language:English   Presentation type:Poster presentation  

  • Nakagawa I, Nakata M, Kawabata S, Hamada S.   Cytochrome c mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes infected epithelial cells.   International conference

    101st General Meeting of American Society for Microbiology 

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    Event date: 2001.5

    Language:English   Presentation type:Poster presentation  

  • Nakagawa I, Kimura KR, Nakata M, Kuwata H, Kawabata S, Hamada S.   A fibronectin - Fc fusion protein protects from group A streptococcal infection.   International conference

    100th General Meeting of American Society for Microbiology 

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    Event date: 2000.5

    Language:English   Presentation type:Poster presentation  

  • Nakagawa I, Kimura KR, Nakata M, Kuwata H, Kawabata S, Hamada S.   Effects of Receptor-globulins on invasive Group A Streptococcal infection.   International conference

    14th Lancefield International Symposium on Streptococci and Streptococcal Diseases 

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    Event date: 1999.10

    Language:English   Presentation type:Poster presentation  

  • Nakagawa I, Nakata M, Kawabata S, Hamada S.   Induction of apoptosis by regulated expression of the Shiga toxin B gene.   International conference

    99th General Meeting of the American Society for Microbiology 

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    Event date: 1999.5 - 1999.6

    Language:English   Presentation type:Poster presentation  

  • 窪田 星子, 中田 匡宣, 広瀬 雄二郎, 山口 雅也, 住友 倫子, 川端 重忠   血清型M49型Streptococcus pyogenesのCvfAは病原因子の発現と温度依存性の線毛産生に関与する  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • 李 怡萱, 中田 匡宣, 住友 倫子, 広瀬 雄二郎, 竹村 萌, 山口 雅也, 岡橋 暢夫, 川端 重忠   血清型M18型Streptococcus pyogenesのnra遺伝子に存在するナンセンス変異への点変異導入は温度依存性の線毛産生を誘導する(Restoration of intact nra transcriptional regulator into serotype M18 Streptococcus pyogenes induced thermosensitive pilus production)  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 本多 真理子, 住友 倫子, Hamd Dalia, 毛利 泰士, 山口 雅也, 中田 匡宣, 川端 重忠   肺炎球菌性肺炎の発症における2コンポーネント調節系TSC08の関与(Involvement of two-component regulatory system TCS08 in pneumococcal pneumonia pathogenesis)  

    日本細菌学雑誌  2019.3  日本細菌学会

  • 竹村 萌, 山口 雅也, 広瀬 雄二郎, 住友 倫子, 中田 匡宣, 川端 重忠   肺炎球菌の菌体表層タンパク質BgaAが病態形成に果たす役割  

    日本細菌学雑誌  2020.1  日本細菌学会

  • 山口 雅也, 中田 匡宣, 住岡 龍一, 和田 聖史, 広瀬 雄二郎, 明田 幸宏, 住友 倫子, 川端 重忠   肺炎球菌のジンクメタロプロテアーゼの系統解析と髄膜炎発症に果たす役割の解明  

    日本細菌学雑誌  2017.2  日本細菌学会

  • 後藤 花奈, 山口 雅也, 広瀬 雄二郎, 住友 倫子, 中田 匡宣, 川端 重忠   肺炎球菌のコリン結合タンパク質CbpJおよびCbpLの肺炎発症における役割の解析  

    日本細菌学雑誌  2018.2  日本細菌学会

  • 山口 雅也, 広瀬 雄二郎, 後藤 花奈, 竹村 萌, 住友 倫子, 中田 匡宣, 川端 重忠   肺炎球菌のβ-ヘリックス構造タンパク質PfbAを介した貪食回避機構の解析  

    日本細菌学雑誌  2018.2  日本細菌学会

  • 竹村 萌, 山口 雅也, 後藤 花奈, 広瀬 雄二郎, 住友 倫子, 中田 匡宣, 川端 重忠   肺炎球菌のβ-ガラクトシダーゼBgaAの進化的な保存性と病態に果たす役割の解析  

    日本細菌学雑誌  2019.3  日本細菌学会

  • 広瀬 雄二郎, 山口 雅也, 後藤 花奈, 住友 倫子, 中田 匡宣, 川端 重忠   肺炎球菌のCcs4は脳血管内皮細胞への侵入に寄与する病原因子である  

    日本細菌学雑誌  2017.2  日本細菌学会

  • 高原 悠樹, 住友 倫子, 山口 雅也, 中田 匡宣, 川端 重忠   肺炎球菌が非血行性に脳へ伝播する機構の解析  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • 住友 倫子, 中田 匡宣, 長瀬 賢史, 高原 悠樹, 山口 雅也, 岡本 成史, 川端 重忠   病原性 インフルエンザに続発する細菌性肺炎の発症におけるGP96の機能解析  

    日本細菌学雑誌  2020.1  日本細菌学会

  • 中田 匡宣   環境に対応する微生物の生存戦略 mRNAサーモセンサーにより制御される化膿レンサ球菌の温度感受性線毛産生(Microbial strategies for survival in response to environmental factors Thermosensitive pilus production by Streptococcus pyogenes via mRNA thermosensor)  

    日本細菌学雑誌  2020.1  日本細菌学会

  • 中田 匡宣, 住友 倫子, 川端 重忠   温度感受性転写因子の翻訳効率に依存する化膿レンサ球菌の線毛発現  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 山口 雅也, 後藤 花奈, 竹村 萌, 広瀬 雄二郎, 住友 倫子, 中田 匡宣, 川端 重忠   宿主と病原体が織りなす進化の謎 進化的な保存性の評価に基づく肺炎球菌の病原因子の探索  

    日本細菌学雑誌  2019.3  日本細菌学会

  • 広瀬 雄二郎, 山口 雅也, 後藤 花奈, 住友 倫子, 中田 匡宣, 川端 重忠   化膿レンサ球菌のアルギニンデイミナーゼArcAは低グルコース環境下で病原因子の発現に寄与する  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 広瀬 雄二郎, 山口 雅也, 後藤 花奈, 住友 倫子, 中田 匡宣, 川端 重忠   化膿レンサ球菌のアルギニンデイミナーゼArcAは低グルコース環境下で病原因子の発現に寄与する  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 本多 真理子, 住友 倫子, 山口 雅也, 中田 匡宣, 川端 重忠   化膿レンサ球菌のendopeptidase Oと補体C1qの相互作用が病原性に及ぼす影響  

    日本細菌学雑誌  2017.2  日本細菌学会

  • 中田 匡宣, 住友 倫子, 川端 重忠   化膿レンサ球菌による温度依存性の線毛産生  

    日本細菌学雑誌  2019.3  日本細菌学会

  • 中田 匡宣, 住友 倫子, 川端 重忠   化膿レンサ球菌における温度感受性の線毛発現機構  

    Journal of Oral Biosciences Supplement  2017.9  (一社)歯科基礎医学会

  • 東 孝太郎, 武部 克希, 山口 雅也, 住友 倫子, 中田 匡宣, 鈴木 守, 川端 重忠   化膿レンサ球菌におけるヒアルロン酸分解酵素の分子系統解析およびタンパク質構造解析  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 広瀬 雄二郎, 山口 雅也, 秋山 徹, 竹本 訓彦, 奥野 ルミ, 山口 貴弘, 大塚 仁, 住友 倫子, 中田 匡宣, 川端 重忠   分類・疫学・感染症 Streptococcus pyogenes emm 89型の侵襲性に寄与する因子の検索  

    日本細菌学雑誌  2020.1  日本細菌学会

  • 山口 雅也, 後藤 花奈, 広瀬 雄二郎, 竹村 萌, 住友 倫子, 中田 匡宣, 川端 重忠   分子進化解析に基づく肺炎球菌のコリン結合タンパク質群の選択圧の評価  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 岡橋 暢夫, 中田 匡宣, 広瀬 雄二郎, 桑田 啓貴, 川端 重忠   ミティス群レンサ球菌が産生する過酸化水素はマスト細胞の細胞死を誘導し、脱顆粒を抑制する  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 花田 知己, 広瀬 雄二郎, 山口 雅也, 住友 倫子, 中田 匡宣, 川端 重忠   マウス壊死性筋膜炎モデルの感染局所におけるStreptococcus pyogenesの遺伝子発現解析  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 住友 倫子, 中田 匡宣, 山口 雅也, 川端 重忠   インフルエンザ感染によるGP96シャペロンの活性化は肺炎球菌の肺胞上皮細胞への付着を亢進させる  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 住友 倫子, 中田 匡宣, 山口 雅也, 川端 重忠   インフルエンザウイルス感染は化膿レンサ球菌の上皮バリア突破を亢進させる  

    日本細菌学雑誌  2017.2  日本細菌学会

  • 住友 倫子, 中田 匡宣, 山口 雅也, 川端 重忠   インフルエンザウイルス感染によるSnail1の発現誘導は化膿レンサ球菌の上皮バリア突破を亢進させる  

    Journal of Oral Biosciences Supplement  2017.9  (一社)歯科基礎医学会

  • 住友 倫子, 中田 匡宣, 長瀬 賢史, 高原 悠樹, 山口 雅也, 岡本 成史, 川端 重忠   インフルエンザに続発する細菌性肺炎の発症におけるGP96の機能解析  

    日本細菌学雑誌  2020.1  日本細菌学会

  • 李 怡萱, 中田 匡宣, 岡橋 暢夫, 山口 雅也, 住友 倫子, 川端 重忠   Streptococcus sanguinisが産生する線毛の構成因子(Component analysis of pili in Streptococcus sanguinis)  

    日本細菌学雑誌  2019.3  日本細菌学会

  • 李 怡萱, 中田 匡宣, 岡橋 暢夫, 山口 雅也, 住友 倫子, 川端 重忠   Streptococcus sanguinisが産生する細菌壁架橋型線毛の構成因子  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 広瀬 雄二郎, 山口 雅也, 花田 知己, 住友 倫子, 中田 匡宣, 川端 重忠   Streptococcus pyogenesは低グルコース環境においてアルギニン代謝依存的に遺伝子発現を変動させる  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 広瀬 雄二郎, 山口 雅也, 毛利 泰士, 後藤 花奈, 住友 倫子, 中田 匡宣, 川端 重忠   Streptococcus pyogenesのアルギニン代謝系が病変形成に果たす役割の解析  

    日本細菌学雑誌  2019.3  日本細菌学会

  • 広瀬 雄二郎, 山口 雅也, 毛利 泰士, 後藤 花奈, 住友 倫子, 中田 匡宣, 川端 重忠   Streptococcus pyogenesが産生するArcAは皮膚病変形成に寄与する  

    日本細菌学雑誌  2018.2  日本細菌学会

  • 山口 雅也, 広瀬 雄二郎, 竹村 萌, 大野 誠之, 住友 倫子, 中田 匡宣, 寺尾 豊, 川端 重忠   Streptococcus pneumoniaeは種特異的なタンパク質PfbAにより過剰に免疫応答を伴う宿主の死亡を抑制する  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 広瀬 雄二郎, 山口 雅也, 後藤 花奈, 住友 倫子, 中田 匡宣, 川端 重忠   Streptococcus pneumoniae Ccs4は脳血管内皮細胞への付着・侵入を促進する病原因子である  

    生命科学系学会合同年次大会  2017.12  生命科学系学会合同年次大会運営事務局

  • 中田匡宣   化膿レンサ球菌におけるサーモセンサーの発見   Invited

    第3回南九州歯学会学術大会  2021 

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  • 高原 悠樹, 住友 倫子, 河野 正充, 山口 雅也, 中田 匡宣, 保富 宗城, 川端 重忠   選抜ワークショップ3:病原性(毒素・エフェクター・生理活性物質・接着因子・定着因子) 肺炎球菌のニューモライシンによる鼻粘膜上皮バリアの傷害と脳伝播機構の解析  

    日本細菌学雑誌  2022.2  日本細菌学会

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  • 岡橋 暢夫, 沖永 敏則, 桜井 敦朗, 寺尾 豊, 中田 匡宣, 川端 重忠, 西原 達次   過酸化水素は口腔レンサ球菌の隠れた病原因子かもしれない  

    Journal of Oral Biosciences Supplement  2013.9  (一社)歯科基礎医学会

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  • 赤松 由佳子, 住友 倫子, 高原 悠樹, 山口 雅也, 中田 匡宣, 明石 満, 川端 重忠   肺炎球菌を感染させた三次元肺組織モデルにおける上皮バリアの機能障害と炎症応答の解析(Analysis of lung epithelial barrier dysfunction and inflammatory response using three-dimensional lung tissue model infected with Streptococcus pneumoniae)  

    Journal of Oral Biosciences Supplement  2022.9  (一社)歯科基礎医学会

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  • 山口 雅也, 広瀬 雄二郎, 後藤 花奈, 住友 倫子, 中田 匡宣, 川端 重忠   肺炎球菌の菌体表層タンパクPfbAは宿主の自然免疫機構からの回避に寄与する  

    Journal of Oral Biosciences Supplement  2016.9  (一社)歯科基礎医学会

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  • 高原 悠樹, 住友 倫子, 山口 雅也, 中田 匡宣, 川端 重忠, 河野 正充, 保富 宗城   肺炎球菌のニューモライシン依存的な鼻粘膜バリア傷害と脳への伝播機構の関連(Pneumolysin-dependent dysfunction of the nasal epithelial barrier is involved in pneumococcal dissemination to brain tissue)  

    Journal of Oral Biosciences Supplement  2021.10  (一社)歯科基礎医学会

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  • 毛利 泰士, 住友 倫子, 本多 真理子, 山口 雅也, 寺尾 豊, 中田 匡宣, 川端 重忠   細菌病原性の分子機序研究の最前線 Streptococcus pyogenesのシステインプロテアーゼによるデスモグレイン分解が皮膚感染症の発症に及ぼす影響  

    日本細菌学雑誌  2016.2  日本細菌学会

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  • 中田 匡宣, 住友 倫子, 浜田 茂幸, 川端 重忠   細菌の環境シグナル受容体と遺伝子調節ネットワーク Streptococcus pyogenesが産生するFCT3型線毛の発現調節機構の解析(Bacterial signal receptors and networks for gene regulation Regulation of pilus gene expression in FCT type 3 strain of Streptococcus pyogenes)  

    日本細菌学雑誌  2014.2  日本細菌学会

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  • 住友 倫子, 中田 匡宣, 寺尾 豊, 川端 重忠   細胞間隙経路を介したA群レンサ球菌の上皮細胞バリア突破機構にはストレプトリジンSが関与する(Streptolysin S contributes to group A streptococcal paracellular translocation across epithelial cells)  

    日本細胞生物学会大会講演要旨集  2010.5  (一社)日本細胞生物学会

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  • 高原 悠樹, 住友 倫子, 河野 正充, 山口 雅也, 中田 匡宣, 保富 宗城, 川端 重忠   病原因子と生態防御(感染モデル・寄生・免疫・ワクチン)/病原体と感染症 鼻咽腔に定着する肺炎球菌が非血行性に脳へ伝播する機構の解析  

    日本細菌学雑誌  2021.2  日本細菌学会

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  • 中田 匡宣, 住友 倫子, 山口 雅也, 川端 重忠   環境温度の変化に対する肺炎球菌の適応と血中における菌体生存の関連  

    Journal of Oral Biosciences Supplement  2016.9  (一社)歯科基礎医学会

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  • 中田 匡宣, 中川 一路, 川端 重忠, 浜田 茂幸   志賀毒素遺伝子を導入したマウス由来大腸菌の経口感染と宿主の応答  

    日本細菌学雑誌  1999.2  日本細菌学会

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  • 東 孝太郎, 山口 雅也, 中田 匡宣, 武部 克希, 住友 倫子, 鈴木 守, 川端 重忠   微生物の分子論(遺伝子・タンパク質・情報伝達・代謝・各種オミクス等) 結晶構造解析に基づく化膿レンサ球菌におけるヒアルロン酸分解酵素の分子機構解明  

    日本細菌学雑誌  2021.2  日本細菌学会

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  • 広瀬 雄二郎, 山口 雅也, 後藤 花奈, 住友 倫子, 中田 匡宣, 川端 重忠   形質転換誘導性タンパク質Ccs4がStreptococcus pneumoniaeの病原性に与える影響  

    Journal of Oral Biosciences Supplement  2016.9  (一社)歯科基礎医学会

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  • 山口 雅也, 広瀬 雄二郎, 住友 倫子, 中田 匡宣, 川端 重忠   常在菌と病原菌の狭間 肺炎球菌の菌体表層タンパクPfbAによる自然免疫回避機構の解析  

    日本細菌学雑誌  2016.2  日本細菌学会

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  • 東野 美晴, 住友 倫子, 中田 匡宣, 寺尾 豊, 川端 重忠   宿主細胞間接着分子の破壊に関与するA群レンサ球菌プロテアーゼの検索  

    日本細菌学雑誌  2010.2  日本細菌学会

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  • 中川 一路, 中田 匡宣, 川端 重忠, 浜田 茂幸   大腸菌志賀毒素遺伝子の細胞内導入による細胞機能の阻害メカニズムの解析  

    日本細菌学雑誌  1999.2  日本細菌学会

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  • 中田 匡宣, 住友 倫子, 山口 雅也, 川端 重忠   培養温度の変化が肺炎球菌の血中での生存に及ぼす影響  

    日本細菌学雑誌  2016.2  日本細菌学会

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  • 住友 倫子, 中田 匡宣, 山口 雅也, 川端 重忠   口腔病原体と宿主のinteraction その新たな展開 プラスミノゲンは三細胞性タイトジャンクションを介してグループA連鎖球菌の上皮転移を促進する(Interactions between oral pathogens and their hosts: new cutting edge Plasminogen promotes group A streptococcal epithelial translocation via tricellular tight junctions)  

    日本細菌学雑誌  2015.2  日本細菌学会

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  • 岡橋 暢夫, 中田 匡宣, 住友 倫子, 寺尾 豊, 川端 重忠   口腔レンサ球菌が産生する過酸化水素がマクロファージの細胞死を誘導する(Hydrogen peroxide produced by oral streptococci induces macrophage cell death)  

    日本細菌学雑誌  2014.2  日本細菌学会

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  • 岡橋 暢夫, 中田 匡宣, 桜井 敦朗, 寺尾 豊, 山口 雅也, 星野 倫範, 川端 重忠, 大嶋 隆   口腔レンサ球菌S.sanguinis線毛piliの機能  

    日本細菌学雑誌  2010.2  日本細菌学会

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  • 岡橋 暢夫, 中田 匡宣, 川端 重忠   口腔レンサ球菌2型線毛の分布とその機能  

    Journal of Oral Biosciences Supplement  2014.9  (一社)歯科基礎医学会

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  • Okahashi Nobuo, Nakata Masanobu, Terao Yutaka, Isoda Ryutaro, Sakurai Atsuo, Sumitomo Tomoko, Yamaguchi Masaya, Kimura Richard K., Oiki Eiji, Kawabata Shigetada, Ooshima Takashi   口腔のStreptococcus sanguinisの線毛は唾液アミラーゼと結合し生物膜形成を促進する(PILI OF ORAL STREPTOCOCCUS SANGUINIS BIND TO SALIVARY AMYLASE AND PROMOTE BIOFILM FORMATION)  

    日本細菌学雑誌  2011.10  日本細菌学会

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  • 東 孝太郎, 山口 雅也, 中田 匡宣, 武部 克希, 住友 倫子, 鈴木 守, 川端 重忠   化膿レンサ球菌の不活性型ヒアルロン酸分解酵素の結晶構造解析と活性型変異体の構造予測(Structural analysis of Streptococcus pyogenes hyaluronidase and in silico analysis based on structural models)  

    Journal of Oral Biosciences Supplement  2021.10  (一社)歯科基礎医学会

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  • 寺尾 豊, 川端 重忠, 中田 匡宣, 中川 一路, 浜田 茂幸   劇症型A群レンサ球菌感染症患者分離株に発現する新たなフィブロネクチン結合タンパクの解析  

    日本細菌学雑誌  2003.2  日本細菌学会

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  • 中川 一路, 黒川 顕, 中田 匡宣, 冨安 祐介, 岡橋 暢夫, 川端 重忠, 浜田 茂幸   劇症型A群レンサ球菌SSI-1株の全ゲノム解析  

    日本細菌学雑誌  2002.2  日本細菌学会

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  • 冨安 祐介, 中川 一路, 中田 匡宣, 岡橋 暢夫, 川端 重忠, 浜田 茂幸   全ゲノムPCRスキャニングによるA群S.pyogenesゲノムの比較解析  

    日本細菌学雑誌  2003.2  日本細菌学会

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  • 住友 倫子, 中田 匡宣, 毛利 泰士, 小川 真理子, 山口 雅之, 川端 重忠   インフルエンザウイルス感染に伴い上皮表層に誘導されるGP96は化膿レンサ球菌の上皮細胞への付着を亢進させる  

    Journal of Oral Biosciences Supplement  2016.9  (一社)歯科基礎医学会

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  • 中田 匡宣, 住友 倫子, 東野 美晴, 岡橋 暢夫, 浜田 茂幸, 寺尾 豊, 川端 重忠   T6線毛の組立て機構の解析(Assembly Mechanism of T6 Pili in Serotype M6 Streptococcus pyogenes)  

    日本細菌学雑誌  2012.2  日本細菌学会

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  • 住岡 龍一, 中田 匡宣, 和田 聖史, 岡橋 暢夫, 住友 倫子, 山口 雅也, 林 美加子, 川端 重忠   Stretptococcus sanguinis由来の過酸化水素は好中球にNETsを誘導する  

    日本細菌学雑誌  2016.2  日本細菌学会

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  • 岡橋 暢夫, 沖永 敏則, 桜井 敦朗, 寺尾 豊, 中田 匡宣, 川端 重忠, 西原 達次   Streptococcus sanguinisはマクロファージの泡沫化と細胞死を誘導する(Streptococcus sanguinis induces foam cell formation and cell death of macrophages)  

    日本細菌学雑誌  2013.2  日本細菌学会

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  • 中川 一路, 黒川 顕, 中田 匡宣, 川端 重忠, 浜田 茂幸   Streptococcus pyogenesゲノムのリアレンジメントによるファージ遺伝子の再構成  

    日本細菌学雑誌  2003.2  日本細菌学会

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  • 本多 真理子, 寺尾 豊, 住友 倫子, 中田 匡宣, 川端 重忠   Streptococcus pyogenesのシステインプロテアーゼSpeBによる補体免疫系回避機構  

    日本細菌学雑誌  2013.2  日本細菌学会

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  • 毛利 泰士, 住友 倫子, 中田 匡宣, 川端 重忠   Streptococcus pyogenesのC3様ADPリボシルトランスフェラーゼSpyAの機能解析  

    日本細菌学雑誌  2014.2  日本細菌学会

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  • 毛利 泰士, 住友 倫子, 山口 雅也, 中田 匡宣, 寺尾 豊, 川端 重忠   Streptococcus pyogenesに起因する皮膚感染症の発症におけるSpeBの関与  

    Journal of Oral Biosciences Supplement  2015.9  (一社)歯科基礎医学会

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  • 中田 匡宣, 中川 一路, 冨安 祐介, 川端 重忠, 浜田 茂幸   Streptococcus pyogenesにおける二成分シグナル伝達系遺伝子群の解析  

    日本細菌学雑誌  2003.2  日本細菌学会

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  • 中田 匡宣, 住友 倫子, 寺尾 豊, 浜田 茂幸, 川端 重忠   Streptococcus pyogenesが産生するFCT3型線毛の細胞壁架橋機構の解析(Cell wall anchoring mechanism of FCT region type 3 pili in Streptococcus pyogenes)  

    日本細菌学雑誌  2013.2  日本細菌学会

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  • 中田 匡宣, 住友 倫子, 浜田 茂幸, 川端 重忠   Streptococcus pyogenesが産生するFCT3型線毛の発現調節機構の解析(Regulation of pilus gene expression in FCT type 3 strain of Streptococcus pyogenes)  

    日本細菌学雑誌  2014.2  日本細菌学会

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  • 寺尾 豊, 加藤 千景, 中田 匡宣, 浜田 茂幸, 川端 重忠   Streptococcus pyogenes FbaBの細胞付着侵入および発現調節の解析  

    日本細菌学雑誌  2005.2  日本細菌学会

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  • 広瀬 雄二郎, 山口 雅也, 後藤 花奈, 住友 倫子, 中田 匡宣, 川端 重忠   Streptococcus pneumoniaeの形質転換誘導性タンパクCcs4は病原因子として働く  

    日本細菌学雑誌  2016.2  日本細菌学会

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  • 寺尾 豊, 山口 雅也, 中田 匡宣, 浜田 茂幸, 川端 重忠   Streptococcus pneumoniaeに対するキメラ免疫グロブリン製剤の構築  

    Journal of Oral Biosciences  2007.8  (一社)歯科基礎医学会

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  • 中田 匡宣, 住友 倫子, 寺尾 豊, 川端 重忠   M6型A群レンサ球菌が産生するFCT1型線毛遺伝子の転写調節  

    日本細菌学雑誌  2015.2  日本細菌学会

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  • 山口 雅也, 中田 匡宣, 住友 倫子, 川端 重忠   M4型Streptococcus pyogenesのヒアルロン酸分解酵素が宿主細胞内生存に果たす役割  

    日本細菌学雑誌  2015.2  日本細菌学会

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  • 冨安 祐介, 中川 一路, 中田 匡宣, 川端 重忠, 浜田 茂幸   EGFP高発現A群レンサ球菌を用いた宿主細胞への付着・侵入能の解析  

    日本細菌学雑誌  2001.2  日本細菌学会

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  • Ara Takahide, Ota Shuichi, Shima Kanako, Yasumoto Atsushi, Minauchi Koichiro, Obara Masato, Nakata Masanobu, Imai Kiyotoshi, Hirano Teiichi, Ogasawara Masahiro, Kiyama Yoshio, Kobayashi Naoki, Imamura Masahiro   Cefepimeに治療不応性の発熱性好中球減少症患者に対するABK投与とVCM投与とを比較する前向き無作為化研究(Prospective randomized study of ABK vs VCM for febrile neutropenic patients in refractory to CFPM)  

    臨床血液  2013.9  (一社)日本血液学会-東京事務局

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  • 作田 哲也, 大貝 悠一, 中田 匡宣   Candida albicansの増殖とバイオフィルム形成に対するフロリジンの影響  

    日本細菌学雑誌  2021.2  日本細菌学会

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  • 小川 真理子, 住友 倫子, 毛利 泰士, 山口 雅也, 中田 匡宣, 川端 重忠   C1qとの相互作用を介する化膿レンサ球菌の補体免疫回避機構  

    Journal of Oral Biosciences Supplement  2016.9  (一社)歯科基礎医学会

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  • 住友 倫子, 中田 匡宣, 山口 雅也, 川端 重忠   Bacteria meet Viral Infection インフルエンザウイルス感染に伴うGp96の局在と化膿レンサ球菌感染症の関連性  

    日本細菌学雑誌  2016.2  日本細菌学会

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  • 住友 倫子, 東野 美晴, 中田 匡宣, 川端 重忠   A群連鎖球菌は三細胞間タイトジャンクションを介して上皮のバリアを越えて移動する(Group A Streptococcus translocates across epithelial barrier via tricellular tight junctions)  

    日本細菌学雑誌  2014.2  日本細菌学会

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  • 中田 匡宣, 住友 倫子, 寺尾 豊, 川端 重忠   A群レンサ球菌線毛の温度感受性発現機構の解析  

    日本細菌学雑誌  2009.2  日本細菌学会

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  • 中田 匡宣, 住友 倫子, 寺尾 豊, 川端 重忠   A群レンサ球菌線毛の機能解析  

    日本細菌学雑誌  2008.2  日本細菌学会

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  • 中田 匡宣, 中川 一路, 川端 重忠, 浜田 茂幸   A群レンサ球菌感染による上皮細胞のアポトーシスとその制御機構  

    日本細菌学雑誌  2001.2  日本細菌学会

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  • 住友 倫子, 中田 匡宣, 寺尾 豊, 川端 重忠   A群レンサ球菌は宿主カルパインの活性化を介して上皮バリアを突破する  

    Journal of Oral Biosciences Supplement  2013.9  (一社)歯科基礎医学会

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  • 住友 倫子, 中田 匡宣, 寺尾 豊, 川端 重忠   A群レンサ球菌の分泌型システインプロテアーゼであるSpeBは上皮細胞間接着分子を分解する  

    Journal of Oral Biosciences  2011.9  (一社)歯科基礎医学会

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  • 中川 一路, 中田 匡宣, 川端 重忠, 浜田 茂幸   A群レンサ球菌の侵入によるヒト上皮細胞における遺伝子発現の解析  

    日本細菌学雑誌  2000.4  日本細菌学会

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  • 住友 倫子, 中田 匡宣, 東野 美晴, 寺尾 豊, 川端 重忠   A群レンサ球菌の上皮バリア突破機構に関与する宿主プロテアーゼの解析  

    日本細菌学雑誌  2010.2  日本細菌学会

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  • 住友 倫子, 中田 匡宣, 寺尾 豊, 川端 重忠   A群レンサ球菌の上皮バリア突破機構に関する解析  

    日本細菌学雑誌  2009.2  日本細菌学会

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  • 中田 匡宣, 中川 一路, 川端 重忠, 浜田 茂幸   A群レンサ球菌のヒト上皮細胞への侵入によるアポトーシス誘導機構の解析  

    日本細菌学雑誌  2000.4  日本細菌学会

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  • 住友 倫子, 東野 美晴, 小南 明里, 中田 匡宣, 寺尾 豊, 川端 重忠   A群レンサ球菌のシステインプロテアーゼSpeBおよびSib35による上皮細胞間接着分子の分解(Group A streptococcal cysteine proteases, SpeB and Sib35, cleave epithelial junctions)  

    日本細菌学雑誌  2013.2  日本細菌学会

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  • 本多 真理子, 住友 倫子, 毛利 泰士, 山口 雅也, 中田 匡宣, 川端 重忠   A群レンサ球菌のendopeptidase Oによる補体C1qを介した補体免疫回避機構  

    日本細菌学雑誌  2016.2  日本細菌学会

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  • 中川 一路, 中田 匡宣, 冨安 祐介, 川端 重忠, 浜田 茂幸   A群レンサ球菌による上皮細胞死誘導機構の解析  

    日本細菌学雑誌  2002.2  日本細菌学会

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  • 中田 匡宣, 寺尾 豊, 川端 重忠   A群レンサ球菌が産生する線毛の機能解析  

    Journal of Oral Biosciences  2008.9  (一社)歯科基礎医学会

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  • 高原 悠樹, 住友 倫子, 河野 正充, 赤松 由佳子, 山口 雅也, 中田 匡宣, 保富 宗城, 川端 重忠.   肺炎球菌のニューモライシン依存的な鼻粘膜上皮バリア傷害と脳伝播機構の解析.  

    第52回 レンサ球菌研究会  2022.7 

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    Venue:仙台市  

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Awards

  • 大阪大学総長奨励賞 2015

    2015.7   大阪大学  

    中田 匡宣

Research Projects

  • 細菌における新規翻訳制御機構の探索

    2019 - 2020

    日本学術振興会  挑戦的研究(萌芽) 

    中田 匡宣

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  • レンサ球菌のニッチ拡大に伴う宿主-菌体相互作用の解析

    2017 - 2019

    日本学術振興会  基盤研究(B) 

    中田 匡宣

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  • 菌体表層に存在する線維状タンパク質重合体の会合と抗原性がもたらす病原性の探索

    2017 - 2018

    日本学術振興会 

    中田 匡宣

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  • レンサ球菌が産生する線毛の付着機能と発現機構の解析

    2016 - 2019

    日本学術振興会  国際共同研究加速基金(国際共同研究強化) 

    中田 匡宣

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