研究者詳細 - 山下　薫

論文 - 山下　薫

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Yoshimine S, Yamashita K, Higa Y, Uto A, Uchino M, Sugimura M . Monitor feedback versus instructor feedback for post-pandemic basic life support training: a randomized controlled trial among dental students . BMC Med Edu25 ( 1 ) 918 2025年7月査読

Yamashita K, Kibe T, Uto A, Yoshimine S, Uchino M, Sugimura M . Music and sedation relieve intraoperative stress: A randomized controlled trial . PLOS One20 ( 5 ) e0325038 2025年5月査読

Kaoru Yamashita, Shusei Yoshimine, Akari Uto, Minako Uchino, Toshiro Kibe, Mitsutaka Sugimura . Screening Female Patients With Autonomic Nervous System Imbalance Using the Toho Medical Index Before Tooth Extraction . Cureus16 ( 12 ) e76345 2024年12月査読

中原真由美、山田知嗣、五代幸平、山下　薫、石畑清秀、内野えりか、松永　明 . 顎関節症および咀嚼筋腱・腱膜過形成症による麻酔導入後の開口障害に対し、歯科用バイトブロックが有用であった1症例 . 麻酔73 ( 12 ) 853 - 857 2024年12月査読

山口孝二郎、砂川正隆、新田英明、鈴木　甫、山下　薫、杉村　光隆 . 1年以上続く舌・口腔内疼痛に漢方を含む東洋医学的治療が奏効した１例 . 痛みと漢方33 47 - 52 2024年6月査読

新田英明、山口孝二郎、鈴木　甫、山下　薫、杉村光隆 . 口腔内に発症した痛覚辺調整疼痛に関して漢方薬が有効であった１症例 . 痛みと漢方33 53 - 58 2024年6月査読

Uto A., Yamashita K., Yoshimine S., Uchino M., Kibe T., Sugimura M. . Analysis of perioperative autonomic nervous system activity to visualize stress in pediatric patients undergoing alveolar bone graft surgery . Journal of Clinical Monitoring and Computing 2024年

記述言語：日本語出版者・発行元：Journal of Clinical Monitoring and Computing

Perioperative stress in pediatric patients is often difficult to assess via interviews; thus, an objective measure to assess perioperative stress is needed. To visualize perioperative stress, we observed autonomic nervous system (ANS) activity, circulatory dynamics, and psychological status in pediatric patients undergoing alveolar bone grafting under general anesthesia. This prospective observational study included 40 patients aged 8–12 years who were scheduled for alveolar bone grafting in our hospital. ANS activity was analyzed using heart rate variability the day before surgery, during general anesthesia, 2 h postoperatively, 24 h postoperatively, and the day before discharge. ANS assessment included LF/HF (sympathetic nervous system activity) and HF (parasympathetic nervous system activity). Additionally, heart rate (HR), systolic blood pressure (SBP), face scale (FS) score were recorded. Data from 31 patients, excluding dropouts, were analyzed. The ratio of change to the preoperative value was compared. After surgery, the LF/HF, HR, SBP, and FS score significantly increased (P < 0.01) and HF significantly decreased (2 h postoperatively: P < 0.05, 24 h postoperatively, before discharge: P < 0.01). SBP recovered to preoperative values 24 h postoperatively, and HR and FS scores recovered to preoperative values before discharge. However, even before discharge, LF/HF remained significantly higher than preoperative values, and HF remained significantly lower than preoperative values (P < 0.01). Conclusion We observed perioperative stress from multiple perspectives. Circulatory dynamics and psychological status recovered by the day before discharge; however, ANS activity did not. Therefore, evaluating ANS activity may be useful in visualizing potential perioperative stress in pediatric patients.

DOI： 10.1007/s10877-024-01210-w

Scopus

PubMed

Kibe T., Nakazono K., Yamashita K., Tada R., Ono Y., Ishihata K. . Evaluation of Eruption of Permanent Teeth in Beagle Dog Extraction Sites Filled with Carbonate Apatite . Materials16 ( 24 ) 2023年12月

記述言語：日本語出版者・発行元：Materials

Autologous bone grafting is the primary method for treating alveolar clefts. However, bone grafting materials are desired as alternatives to autogenous bone to reduce surgical invasiveness. Here, we present an animal study evaluating the effect of carbonate apatite (CA) on the spontaneous eruption of permanent teeth. The bone grafting materials included CA, natural bovine bone (BB), and hydroxyapatite (HA). In 15 8-week-old male beagle dogs, the left mandibular deciduous premolars (DP) two and three were extracted and subsequently filled with CA, BB, and HA. The animals were euthanized after a predetermined number of days, and samples were collected for microcomputed tomography and histological evaluation. Spontaneous eruption of the succeeding permanent teeth (P3 and P4) was observed in the CA group at 14 weeks. Delayed eruption of the succeeding permanent teeth was observed in the BB and HA groups. CA could serve as a viable alternative to autogenous bone for treating alveolar clefts.

DOI： 10.3390/ma16247624

Scopus

PubMed

Yamashita K., Uto A., Uchino M., Kibe T., Sugimura M. . Listening to music before tooth extraction attenuates sympathetic nervous system activity: A randomized control trial . Oral Science International20 ( 2 ) 88 - 94 2023年5月

記述言語：日本語出版者・発行元：Oral Science International

Aim: The effect of listening to music before tooth extraction on the autonomic nervous system and psychological state remains unclear. This prospective study explored the hypothesis that playing music before the extraction of an impacted mandibular third molar would stabilize patients' autonomic nervous system activity and circulatory dynamics. Methods: Thirty-six patients were randomized into two groups: control and music. Patients in the music group listened to music before tooth extraction. Heart rate variability and circulatory dynamics were recorded during the procedure. The Modified Dental Anxiety Scale and State Trait Anxiety Inventory scale scores were recorded before the procedure, and the latter was used to assess postoperative anxiety scores. Results: Sympathetic nervous activity significantly increased in the control group during the administration of local anesthesia, bone removal, and extraction (p < 0.01), although this increase was lower in the music group during the administration of local anesthesia and extraction (p < 0.05). In the music group, the postoperative anxiety score was significantly lower than the preoperative score (p < 0.05). Conclusion: Playing music preoperatively may help reduce sympathetic nerve activity during the administration of local anesthesia and tooth extraction.

DOI： 10.1002/osi2.1151

Scopus

山下薫, 四道瑠美, 祐德美耀子, 宇都明莉, 吉嶺秀星, 杉村光隆 . 歯科治療恐怖症を有する化学物質過敏症患者における静脈内鎮静法による全身管理経験 . 日本歯科麻酔学会雑誌51 ( 1 ) 4 - 6 2023年1月

山下薫, 吉嶺秀星, 宇都明莉, 比嘉憂理奈, 四道瑠美, 橋口浩平, 白川由紀恵, 杉村光隆 . 定量的な検査と検査結果のフィードバックが治療方針決定の一助となった症例 . 日本口腔顔面痛学会雑誌15 ( 1 ) 27 - 30 2023年

記述言語：日本語出版者・発行元：日本口腔顔面痛学会

症例の概要：38歳女性．下顎管に近接している38抜歯後に左側オトガイ部の知覚異常を認めた．ビタミンB12製剤内服で経過観察されていたが，内服開始後1か月経過しても症状に変化がなく，ペインクリニックでの加療を希望されたため，当院へ紹介となった．左側第3枝三叉神経ニューロパチーの診断のもと，星状神経節ブロックと鍼治療を行なった．星状神経節ブロックによる治療が20回終了したところで症状はDysesthesiaからParesthesiaへ変化していたが，著明な改善が認められないため，患者は治療継続を迷っていた．精密触覚機能検査，電流知覚閾値検査を行ったところ数値上改善を認め，その結果をフィードバックしたところ患者は治療継続を希望した．10回の鍼治療終了後，再度検査を行い，精密触覚機能検査，電流知覚閾値検査においてさらに改善を認め，その結果を患者にフィードバックしたところ，これまでの治療内容と現在の症状に納得し，治療終了を希望したため，終診となった．
 考察：本症例のように患者の訴えに著明な改善が認められなくても，検査値が改善しているケースがある．検査結果に基づいた適切な病態説明は，患者の治療継続と良好な経過へつながる可能性があると考えられた．
 結論：自覚症状の著明な改善が認められず，治療継続を迷っている口腔顔面痛患者において，定量的な検査と改善した検査結果のフィードバックは，患者の治療に対するモチベーションを維持し，その意思決定に有用である．

DOI： 10.11264/jjop.15.27

CiNii Research

Shidou R., Kohjitani A., Miyata M., Yamashita K., Ohno S., Ohishi M., Sugimura M. . Estimation of the Risk of Postoperative Hypertension Following Minor to Moderate Surgery Using an Echocardiogram and Biomarkers . Japanese Heart Journal63 ( 3 ) 558 - 565 2022年5月査読

記述言語：英語出版者・発行元：一般社団法人インターナショナル・ハート・ジャーナル刊行会

This study aimed to determine independent factors for developing postoperative hypertension using 4 biomarkers in patients receiving oral and maxillofacial surgery under general anesthesia. Brain natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity myocardial troponin T (hs-TnT), and high-sensitivity myocardial troponin I (hs-TnI) were measured and preoperative echocardiograms were examined. Episodes of systolic blood pressure (SBP) ≥170 mmHg or diastolic blood pressure ≥100 mmHg within 1 week after surgery were considered postoperative hypertension. We analyzed 213 (130 men; 83 women) patients, who were divided into a postoperative hypertension group (HT group, n = 32) and a normal group (N group, n = 181). The HT group showed a higher LVMI (113.5 versus 100.1), higher E/e’ of the lat-eral wall (9.1 versus 7.7), and higher BNP (39.2 versus 22.9 pg/mL), NT-proBNP (400.1 versus 143.9 pg/mL), and hs-TnT (15.6 versus 10.3 ng/L) concentrations compared to the N group. NT-proBNP and hs-TnT concentrations positively associated with E/e’, but BNP and hs-TnI did not. NT-proBNP (AUC = 0.64, cutoff value: 117.0 pg/mL) and hs-TnT (AUC = 0.61, cutoff value: 11.0 ng/L) concentrations were effective for discriminat-ing E/e’ ≥12. Multivariate logistic regression analyses showed that risk factors responsible for developing postoperative hypertension were NT-proBNP and hs-TnT using biomarkers and E/e’ as independent variables, and NT-proBNP and SBP at admission using biomarkers and SBP at admission as independent variables. These findings suggest that NT-proBNP and hs-TnT concentrations, and SBP at admission, are useful to predict postoperative hypertension after minor to moderate surgery, and that left ventricular filling pressure is a primary factor associated with postoperative hypertension.

DOI： 10.1536/ihj.22-074

Scopus

PubMed

CiNii Research

白川由紀恵, 大野幸, 山下薫, 杉村光隆 . 多剤抗パーキンソン病薬を服用している患者の頰骨・上顎骨骨折に対する観血的整復固定術の麻酔経験 . 日本歯科麻酔学会雑誌50 ( 2 ) 76 - 78 2022年4月

Yamashita K., Uto A., Uchino M., Shidou R., Kibe T., Sugimura M. . Sympathetic Nerve Activity During Tooth Extraction in Women Is Related to Dental Anxiety Immediately After Surgery . Journal of Oral and Maxillofacial Surgery79 ( 11 ) 2268.e1 - 2268.e5 2021年6月査読

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Oral and Maxillofacial Surgery

Purpose: This study assessed the relationship between changes in autonomic nervous system activity during impacted mandibular third molar extraction and a patient's postoperative psychological status, with the overarching aim of informing the development of interventions to reduce dental phobia and anxiety. We hypothesized that changes in autonomic nervous system activity during tooth extraction are related to postoperative psychology. Methods: In our prospective cohort study, heart rate variability, heart rate (HR), and systolic blood pressure (SBP) were recorded during impacted mandibular third molar extraction. Heart rate variability values were dichotomized as either low frequency (LF 0.04-0.15 Hz) or high frequency (HF >0.15 Hz). The relative ratios (intraoperative vs baseline) of LF/HF, HF, HR, and SBP were divided into high and low groups based on their median values; the State Anxiety Inventory (STAI-S) results were compared between the groups with high and low relative ratios. Results: Data of 34 female patients (age, 28.23 ± 1.05 years) were analyzed. Postoperative STAI-S values were significantly lower than preoperative values. Patients in the high LF/HF group had a significantly lower change in STAI-S values than those in the low LF/HF group (P <.05). There were no significant differences in the change in STAI-S values between the groups with high and low HF, HR, or SBP. Conclusions: Patients with low sympathetic nervous system activity had lower anxiety; the LF/HF index was the most sensitive indicator for changes in stress. Additional studies are required to develop optimal interventions for reducing sympathetic nerve activity in patients with dental phobia.

DOI： 10.1016/j.joms.2021.06.019

Scopus

PubMed

Uchino M., Yamashita K., Kibe T., Shidou R., Kohjitani A., Sugimura M. . Effects of intravenous sedation on autonomic nerve activity and the psychological state during tooth extraction: A prospective non-randomized controlled trial . Oral Science International18 ( 2 ) 135 - 140 2021年5月

記述言語：日本語出版者・発行元：Oral Science International

Purpose: Intravenous sedation is considered to decrease patient anxiety and tension during dental treatment, thereby reducing fluctuations in autonomic nerve activity and the risk of medical emergencies. We hypothesized that intravenous sedation would suppress the sympathetic nervous system during tooth extraction and relieve patient anxiety. Accordingly, the purpose of this study was to investigate the effects of intravenous sedation on autonomic nerve activity and psychological state during impacted mandibular third molar (IMTM) extraction. Methods: This prospective study included 40 healthy women scheduled for IMTM extraction under local anesthesia alone (control group; n = 20) or local anesthesia and intravenous sedation (sedation group; n = 20); of these, 34 women were evaluated. Heart rate variability (HRV) was analyzed to evaluate autonomic nerve activity. HRV and circulatory dynamics were measured during the treatment. The Modified Dental Anxiety scale and State-Trait Anxiety Inventory (STAI-S and STAI-T) scores were obtained before treatment. STAI-S scores were also obtained after treatment. Descriptive and bivariate statistical analyses were conducted, and a P-value <.05 was considered statistically significant. Results: The low-frequency/high-frequency ratio was lower in the sedation group than in the control group (P <.01). Compared with the control group, the sedation group showed a significantly greater decrease in post-treatment STAI-S scores relative to pre-treatment scores (P <.01). Conclusions: The findings suggest that sedation suppresses the sympathetic nervous system during IMTM extraction and decreases anxiety after the extraction. Further research should elucidate the mechanisms by which sedation suppresses the sympathetic nervous system.

DOI： 10.1002/osi2.1094

Scopus

Yamashita K, Kibe T, Kohjitani A, Higa Y, Niiro A, Uchino M, Aoyama K, Shidou R, Hashiguchi K, Sugimura M . General Anesthesia During Lip Repair and Palatoplasty After Glenn Surgery. . Anesthesia progress 2020年6月査読

Yamashita K, Kibe T, Aoyama K, Ohno S, Kohjitani A, Sugimura M . The State Anxiety Inventory Is Useful for Predicting the Autonomic Nervous System State of Patients Before the Extraction of an Impacted Mandibular Third Molar. . Journal of oral and maxillofacial surgery 2020年4月査読

Yamashita K, Kibe T, Shidou Rumi, Kohjitani A, Nakamura N,Sugimura M . Difference in the Effects of Lidocaine With Epinephrine and Prilocaine With Felypressin on the Autonomic Nervous System During Extraction of the Impacted Mandibular Third Molar: A Randomized Controlled Trial . Journal of oral and maxillofacial surgery 2020年2月査読

Yamashita K, Kibe T, Ohno S, Kohjitani A, Sugimura M . The Effects of Music Listening During Extraction of the Impacted Mandibular Third Molar on the Autonomic Nervous System and Psychological State. Journal of oral and maxillofacial surgery . Journal of oral and maxillofacial surgery 2019年6月査読

Yamashita K, Kibe T, Ohno S, Uchino M, Higa Y, Niiro A, Nakamura N, Sugimura M . Time to Recovery of Feeding After Alveolar Bone Graft Is Associated With Postoperative Nausea and Vomiting Within 2 Hours in Children. . Clinical medicine insights. 2019年6月査読

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