Updated on 2024/10/16

写真a

 
YAMASHITA Kaoru
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Oral and Maxillofacial Rehabilitation Lecturer
Title
Lecturer

Degree

  • 博士（歯学） ( 2019.6   鹿児島大学 )

Research History

  • Kagoshima University   Lecturer

    2023.4

  • Kagoshima University   Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Oral and Maxillofacial Rehabilitation   Assistant Professor

    2020.5 - 2023.3

  • Kagoshima University   Medical and Dental Hospital, Medical and Dental Sciences Area Medical and Dental Hospital Clinical Center Anesthesia and Critical Care Center   Assistant Professor

    2019.8 - 2020.4

Committee Memberships

  • 日本歯科麻酔学会   第20期、第21期　安全医療委員会委員  

    2024.2   

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    Committee type：Academic society

  • 日本歯科麻酔学会   九州歯科麻酔シンポジウム事務局長  

    2022.10   

Qualification acquired

  • 日本障害者歯科学会 認定医

  • 日本口腔顔面痛学会　認定医

  • 日本歯科麻酔学会専門医

 

Papers

  • Uto A., Yamashita K., Yoshimine S., Uchino M., Kibe T., Sugimura M. .  Analysis of perioperative autonomic nervous system activity to visualize stress in pediatric patients undergoing alveolar bone graft surgery .  Journal of Clinical Monitoring and Computing   2024

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    Language：Japanese   Publisher：Journal of Clinical Monitoring and Computing  

    Perioperative stress in pediatric patients is often difficult to assess via interviews; thus, an objective measure to assess perioperative stress is needed. To visualize perioperative stress, we observed autonomic nervous system (ANS) activity, circulatory dynamics, and psychological status in pediatric patients undergoing alveolar bone grafting under general anesthesia. This prospective observational study included 40 patients aged 8–12 years who were scheduled for alveolar bone grafting in our hospital. ANS activity was analyzed using heart rate variability the day before surgery, during general anesthesia, 2 h postoperatively, 24 h postoperatively, and the day before discharge. ANS assessment included LF/HF (sympathetic nervous system activity) and HF (parasympathetic nervous system activity). Additionally, heart rate (HR), systolic blood pressure (SBP), face scale (FS) score were recorded. Data from 31 patients, excluding dropouts, were analyzed. The ratio of change to the preoperative value was compared. After surgery, the LF/HF, HR, SBP, and FS score significantly increased (P < 0.01) and HF significantly decreased (2 h postoperatively: P < 0.05, 24 h postoperatively, before discharge: P < 0.01). SBP recovered to preoperative values 24 h postoperatively, and HR and FS scores recovered to preoperative values before discharge. However, even before discharge, LF/HF remained significantly higher than preoperative values, and HF remained significantly lower than preoperative values (P < 0.01). Conclusion We observed perioperative stress from multiple perspectives. Circulatory dynamics and psychological status recovered by the day before discharge; however, ANS activity did not. Therefore, evaluating ANS activity may be useful in visualizing potential perioperative stress in pediatric patients.

    DOI： 10.1007/s10877-024-01210-w

    Scopus

    PubMed

  • Kibe T., Nakazono K., Yamashita K., Tada R., Ono Y., Ishihata K. .  Evaluation of Eruption of Permanent Teeth in Beagle Dog Extraction Sites Filled with Carbonate Apatite .  Materials16 ( 24 )   2023.12

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    Language：Japanese   Publisher：Materials  

    Autologous bone grafting is the primary method for treating alveolar clefts. However, bone grafting materials are desired as alternatives to autogenous bone to reduce surgical invasiveness. Here, we present an animal study evaluating the effect of carbonate apatite (CA) on the spontaneous eruption of permanent teeth. The bone grafting materials included CA, natural bovine bone (BB), and hydroxyapatite (HA). In 15 8-week-old male beagle dogs, the left mandibular deciduous premolars (DP) two and three were extracted and subsequently filled with CA, BB, and HA. The animals were euthanized after a predetermined number of days, and samples were collected for microcomputed tomography and histological evaluation. Spontaneous eruption of the succeeding permanent teeth (P3 and P4) was observed in the CA group at 14 weeks. Delayed eruption of the succeeding permanent teeth was observed in the BB and HA groups. CA could serve as a viable alternative to autogenous bone for treating alveolar clefts.

    DOI： 10.3390/ma16247624

    Scopus

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  • Yamashita K., Uto A., Uchino M., Kibe T., Sugimura M. .  Listening to music before tooth extraction attenuates sympathetic nervous system activity: A randomized control trial .  Oral Science International20 ( 2 ) 88 - 94   2023.5

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    Language：Japanese   Publisher：Oral Science International  

    Aim: The effect of listening to music before tooth extraction on the autonomic nervous system and psychological state remains unclear. This prospective study explored the hypothesis that playing music before the extraction of an impacted mandibular third molar would stabilize patients' autonomic nervous system activity and circulatory dynamics. Methods: Thirty-six patients were randomized into two groups: control and music. Patients in the music group listened to music before tooth extraction. Heart rate variability and circulatory dynamics were recorded during the procedure. The Modified Dental Anxiety Scale and State Trait Anxiety Inventory scale scores were recorded before the procedure, and the latter was used to assess postoperative anxiety scores. Results: Sympathetic nervous activity significantly increased in the control group during the administration of local anesthesia, bone removal, and extraction (p < 0.01), although this increase was lower in the music group during the administration of local anesthesia and extraction (p < 0.05). In the music group, the postoperative anxiety score was significantly lower than the preoperative score (p < 0.05). Conclusion: Playing music preoperatively may help reduce sympathetic nerve activity during the administration of local anesthesia and tooth extraction.

    DOI： 10.1002/osi2.1151

    Scopus

  • YAMASHITA Kaoru, SHIDOU Rumi, YUTOKU Miyoko, UTO Akari, YOSHIMINE Shusei, SUGIMURA Mitsutaka .  Systemic Management Using Intravenous Sedation in a Patient with Multiple Chemical Sensitivities and Dentophobia .  Journal of Japanese Dental Society of Anesthesiology51 ( 1 ) 4 - 6   2023.1Systemic Management Using Intravenous Sedation in a Patient with Multiple Chemical Sensitivities and Dentophobia

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    Language：Japanese   Publisher：The Japanese Dental Society of Anesthesiology  

    <p>  Multiple chemical sensitivity is a disease in which autonomic and neuropsychiatric symptoms, such as fatigue, headache, joint pain, insomnia, and dermatitis, occur in response to exposure to a trace amount of a chemical substance. Here, we report the management of intravenous sedation for tooth extraction and caries treatment in a patient with multiple chemical sensitivities.</p><p>  A 57-year-old woman visited a nearby dental clinic complaining of dentin hypersensitivity and requiring tooth extraction and treatment for a root fracture in the mandibular right second molar and caries in the mandibular right first premolar. However, she had a history of chemical hypersensitivity and dentophobia. She was referred to our hospital and was scheduled to undergo intravenous sedation in an environment with minimal exposure to inducers.</p><p>  We monitored her blood pressure, percutaneous arterial oxygen saturation (SpO<sub>2</sub>), and pulse, and a single dose of midazolam (2 mg) and propofol (10 mg) was administered after securing an intravenous route. The continuous administration of propofol was started at 3 mg/kg/h under 3 L/min of oxygen after the patient fell asleep. No symptoms or risks associated with multiple chemical sensitivity were observed during the tooth extraction or caries treatment.</p><p>  The patient was successfully treated in an environment that eliminated the triggers for the onset of symptoms of multiple chemical sensitivity after meticulous interviews with specialists in collaboration with each clinical department. Intravenous sedation using midazolam and propofol under 3 L/min oxygen was a successful approach for minimizing the psychosomatic mechanisms of multiple chemical sensitivity in a patient with dentophobia.</p>

    DOI： 10.24569/jjdsa.51.1_4

  • Yamashita Kaoru, Yoshimine Shusei, Uto Akari, Higa Yurina, Shidou Rumi, Hashiguchi Kohei, Shirakawa Yukie, Sugimura Mitsutaka .  A Case in Which Quantitative Test and Feedback of Test Results Helped Decision of Treatment Policy .  Japanese Journal of Orofacial Pain15 ( 1 ) 27 - 30   2023A Case in Which Quantitative Test and Feedback of Test Results Helped Decision of Treatment Policy

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    Language：Japanese   Publisher：Japanese Society of Orofacial Pain  

    <b>Patients</b>: After a 38-year-old female underwent extraction of tooth 38, which was in close proximity to the mandibular canal, she presented with mental nerve dysesthesia. She was then prescribed vitamin B12. However, her symptoms remained unchanged one month after starting the medication; thus, she requested treatment at a pain clinic. Under the diagnosis of trigeminal neuropathy, she was treated with a stellate ganglion block and acupuncture. After 20 sessions of stellate ganglion block treatment, the pain shifted from dysesthesia to paresthesia; however, there was no significant improvement in subjective symptoms, and the patient was unsure about continuing the treatment. Improvement was observed in the precise tactile function and the electric current perception threshold tests, and these positive results were conveyed to the patient. The patient wanted to continue treatment. After 10 sessions of acupuncture, she was again re-examined. Further improvement was observed in the precise tactile function and the electric current perception threshold tests, and these positive results were conveyed to the patient. As the patient was satisfied with the treatment results and the improvement in her symptoms, she requested treatment cessation.
    <br><b>Discussion</b>: As in the present case, there are cases in which laboratory values improve despite no change in patient complaints about symptoms.
    <br><b>Conclusions</b>: Therefore, for patients, particularly those with orofacial pain, who are hesitant to continue treatment due to a lack of observable change in symptoms, a qualitative examination and provision of feedback on test results showing improvement can be useful in enhancing their decision-making regarding the treatment, thus contributing to the overall improvement in patient satisfaction.

    DOI： 10.11264/jjop.15.27

  • Shidou Rumi, Kohjitani Atsushi, Miyata Masaaki, Yamashita Kaoru, Ohno Sachi, Ohishi Mitsuru, Sugimura Mitsutaka .  Estimation of the Risk of Postoperative Hypertension Following Minor to Moderate Surgery Using an Echocardiogram and Biomarkers .  International Heart Journal63 ( 3 ) 558 - 565   2022.5Reviewed

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    Language：English   Publisher：International Heart Journal Association  

    <p>This study aimed to determine independent factors for developing postoperative hypertension using 4 biomarkers in patients receiving oral and maxillofacial surgery under general anesthesia. Brain natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity myocardial troponin T (hs-TnT), and high-sensitivity myocardial troponin I (hs-TnI) were measured and preoperative echocardiograms were examined. Episodes of systolic blood pressure (SBP) ≥ 170 mmHg or diastolic blood pressure ≥ 100 mmHg within 1 week after surgery were considered postoperative hypertension. We analyzed 213 (130 men; 83 women) patients, who were divided into a postoperative hypertension group (HT group, <i>n</i> = 32) and a normal group (N group, <i>n</i> = 181). The HT group showed a higher LVMI (113.5 versus 100.1), higher E/e' of the lateral wall (9.1 versus 7.7), and higher BNP (39.2 versus 22.9 pg/mL), NT-proBNP (400.1 versus 143.9 pg/mL), and hs-TnT (15.6 versus 10.3 ng/L) concentrations compared to the N group. NT-proBNP and hs-TnT concentrations positively associated with E/e', but BNP and hs-TnI did not. NT-proBNP (AUC = 0.64, cutoff value: 117.0 pg/mL) and hs-TnT (AUC = 0.61, cutoff value: 11.0 ng/L) concentrations were effective for discriminating E/e' ≥ 12. Multivariate logistic regression analyses showed that risk factors responsible for developing postoperative hypertension were NT-proBNP and hs-TnT using biomarkers and E/e' as independent variables, and NT-proBNP and SBP at admission using biomarkers and SBP at admission as independent variables. These findings suggest that NT-proBNP and hs-TnT concentrations, and SBP at admission, are useful to predict postoperative hypertension after minor to moderate surgery, and that left ventricular filling pressure is a primary factor associated with postoperative hypertension.</p>

    DOI： 10.1536/ihj.22-074

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    PubMed

  • SHIRAKAWA Yukie, OHNO Sachi, YAMASHITA Kaoru, SUGIMURA Mitsutaka .  General Anesthesia Management during Surgical Fixation of a Zygomatic and Maxillary Fracture in a Patient Taking Multiple Anti-Parkinsonian Drugs .  Journal of Japanese Dental Society of Anesthesiology50 ( 2 ) 76 - 78   2022.4General Anesthesia Management during Surgical Fixation of a Zygomatic and Maxillary Fracture in a Patient Taking Multiple Anti-Parkinsonian Drugs

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    Language：Japanese   Publisher：The Japanese Dental Society of Anesthesiology  

    <p>  General anesthesia in patients with Parkinson disease should be performed with caution. Caution is particularly needed when patients with Parkinson disease have been prescribed opioids, since the combination of opioids and MAO inhibitors can cause serotonin syndrome and the use of fentanyl can increase muscle stiffness. The withdrawal of anti-Parkinsonian agents can cause the worsening of symptoms and the development of neuroleptic malignant syndrome, while their continued use may cause intraoperative circulatory changes.</p><p>  Here, the case of a 70-year-old male patient with previously diagnosed Parkinson disease who underwent surgical fixation of a left zygomatic and maxillary fracture is reported. The severity of the Parkinson disease was Ⅲ-Ⅳ on the Yahr Scale, and the patient was taking multiple anti-Parkinsonian drugs including dopamine/carbidopa, pramipexole hydrochloride, selegiline hydrochloride, entacapone, and droxidopa. A neurologist instructed the surgical team to limit the use of opioids and to administer levodopa intraoperatively. The patient’s routine medications were continued until the morning of surgery. General anesthesia was induced with intravenous thiamylal sodium, rocuronium bromide, and remifentanil, and the patient was orally intubated. Remifentanil was stopped immediately after intubation. The patient’s blood pressure was controlled with phenylephrine and ephedrine, as appropriate. General anesthesia was maintained with air, oxygen, and sevoflurane ; levodopa was administered intraoperatively. After an uneventful surgery, sugammadex sodium was administered, and the patient was extubated after awakening. Intravenous acetaminophen and flurbiprofen axetil were administered for postoperative analgesia. No worsening of the Parkinson disease symptoms was observed after the operation.</p><p>  In this case, we report a good surgical outcome with minimal opioid use and the continued perioperative administration of antiparkinsonian agents.</p>

    DOI： 10.24569/jjdsa.50.2_76

  • Kaoru Yamashita, Akari Uto, Minako Uchino, Rumi Shidou, Toshiro Kibe, Mitsutaka Sugimura .  Sympathetic Nerve Activity During Tooth Extraction in Women Is Related to Dental Anxiety Immediately After Surgery .  Journal of oral and maxillofacial surgery79 ( 11 ) 2268.e1 - 2268.e5   2021.6Reviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.joms.2021.06.019

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  • Uchino M., Yamashita K., Kibe T., Shidou R., Kohjitani A., Sugimura M. .  Effects of intravenous sedation on autonomic nerve activity and the psychological state during tooth extraction: A prospective non-randomized controlled trial .  Oral Science International18 ( 2 ) 135 - 140   2021.5

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    Language：Japanese   Publisher：Oral Science International  

    Purpose: Intravenous sedation is considered to decrease patient anxiety and tension during dental treatment, thereby reducing fluctuations in autonomic nerve activity and the risk of medical emergencies. We hypothesized that intravenous sedation would suppress the sympathetic nervous system during tooth extraction and relieve patient anxiety. Accordingly, the purpose of this study was to investigate the effects of intravenous sedation on autonomic nerve activity and psychological state during impacted mandibular third molar (IMTM) extraction. Methods: This prospective study included 40 healthy women scheduled for IMTM extraction under local anesthesia alone (control group; n = 20) or local anesthesia and intravenous sedation (sedation group; n = 20); of these, 34 women were evaluated. Heart rate variability (HRV) was analyzed to evaluate autonomic nerve activity. HRV and circulatory dynamics were measured during the treatment. The Modified Dental Anxiety scale and State-Trait Anxiety Inventory (STAI-S and STAI-T) scores were obtained before treatment. STAI-S scores were also obtained after treatment. Descriptive and bivariate statistical analyses were conducted, and a P-value <.05 was considered statistically significant. Results: The low-frequency/high-frequency ratio was lower in the sedation group than in the control group (P <.01). Compared with the control group, the sedation group showed a significantly greater decrease in post-treatment STAI-S scores relative to pre-treatment scores (P <.01). Conclusions: The findings suggest that sedation suppresses the sympathetic nervous system during IMTM extraction and decreases anxiety after the extraction. Further research should elucidate the mechanisms by which sedation suppresses the sympathetic nervous system.

    DOI： 10.1002/osi2.1094

    Scopus

  • Yamashita K, Kibe T, Kohjitani A, Higa Y, Niiro A, Uchino M, Aoyama K, Shidou R, Hashiguchi K, Sugimura M .  General Anesthesia During Lip Repair and Palatoplasty After Glenn Surgery. .  Anesthesia progress   2020.6General Anesthesia During Lip Repair and Palatoplasty After Glenn Surgery.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Yamashita K, Kibe T, Aoyama K, Ohno S, Kohjitani A, Sugimura M .  The State Anxiety Inventory Is Useful for Predicting the Autonomic Nervous System State of Patients Before the Extraction of an Impacted Mandibular Third Molar. .  Journal of oral and maxillofacial surgery   2020.4The State Anxiety Inventory Is Useful for Predicting the Autonomic Nervous System State of Patients Before the Extraction of an Impacted Mandibular Third Molar. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Yamashita K, Kibe T, Shidou Rumi, Kohjitani A, Nakamura N,Sugimura M .  Difference in the Effects of Lidocaine With Epinephrine and Prilocaine With Felypressin on the Autonomic Nervous System During Extraction of the Impacted Mandibular Third Molar: A Randomized Controlled Trial .  Journal of oral and maxillofacial surgery   2020.2Difference in the Effects of Lidocaine With Epinephrine and Prilocaine With Felypressin on the Autonomic Nervous System During Extraction of the Impacted Mandibular Third Molar: A Randomized Controlled TrialReviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Yamashita K, Kibe T, Ohno S, Kohjitani A, Sugimura M .  The Effects of Music Listening During Extraction of the Impacted Mandibular Third Molar on the Autonomic Nervous System and Psychological State. Journal of oral and maxillofacial surgery .  Journal of oral and maxillofacial surgery   2019.6The Effects of Music Listening During Extraction of the Impacted Mandibular Third Molar on the Autonomic Nervous System and Psychological State. Journal of oral and maxillofacial surgeryReviewed

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    Language：English   Publishing type：Doctoral thesis  

  • Yamashita K, Kibe T, Ohno S, Uchino M, Higa Y, Niiro A, Nakamura N, Sugimura M .  Time to Recovery of Feeding After Alveolar Bone Graft Is Associated With Postoperative Nausea and Vomiting Within 2 Hours in Children. .  Clinical medicine insights.   2019.6Time to Recovery of Feeding After Alveolar Bone Graft Is Associated With Postoperative Nausea and Vomiting Within 2 Hours in Children.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • 山下 薫, 岐部俊郎, 糀谷 淳, 比嘉憂理奈, 新納彩子, 内野美菜子, 青山歌奈絵, 四道瑠美, 橋口浩平, 杉村光隆 .  グレン循環患児における口唇形成・口蓋形成術に対する全身麻酔経験 .  日本歯科麻酔学会誌   2019.4グレン循環患児における口唇形成・口蓋形成術に対する全身麻酔経験Reviewed

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • Tohya A, Kohjitani A, Ohno S, Yamashita K, Manabe Y, Sugimura M .  Effects of glucose-insulin infusion during major oral and maxillofacial surgery on postoperative complications and outcomes. .  JA clinical reports   2018.10Effects of glucose-insulin infusion during major oral and maxillofacial surgery on postoperative complications and outcomes.Reviewed

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  • Yamashita K, Kohjitani A, Miyata M, Ohno S, Tohya A, Ohishi M, Sugimura M .  Predictive Factors of Postoperative Blood Pressure Abnormalities Following a Minor-to-Moderate Surgery. .  International heart journal   2018.10Predictive Factors of Postoperative Blood Pressure Abnormalities Following a Minor-to-Moderate Surgery.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Ohno S, Kohjitani A, Miyata M, Tohya A, Yamashita K, Hashiguchi T, Ohishi M, Sugimura M .  Recovery of Endothelial Function after Minor-to-Moderate Surgery Is Impaired by Diabetes Mellitus, Obesity, Hyperuricemia and Sevoflurane-Based Anesthesia. .  International heart journal   2018.5Recovery of Endothelial Function after Minor-to-Moderate Surgery Is Impaired by Diabetes Mellitus, Obesity, Hyperuricemia and Sevoflurane-Based Anesthesia.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • 椙山 加綱, 真鍋 庸三, 大野 幸, 遠矢 明菜, 是枝 清孝, 千堂 良造, 山下 薫, 糀谷 淳 .  鹿児島大学病院歯科診療棟における20年間の異物誤嚥誤飲症例の検討 .  日本歯科麻酔学会雑誌   2016.1鹿児島大学病院歯科診療棟における20年間の異物誤嚥誤飲症例の検討Reviewed

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • 椙山 加綱, 真鍋 庸三, 大野 幸, 遠矢 明菜, 是枝 清孝, 千堂 良造, 山下 薫, 糀谷 淳 .  鹿児島大学病院歯科診療棟における20年間の院内救急コール症例の検討 .  日本歯科麻酔学会雑誌   2015.10鹿児島大学病院歯科診療棟における20年間の院内救急コール症例の検討Reviewed

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

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Presentations

  • 山下　薫   第４回　日野原賞受賞講演   Invited

    第24回日本音楽療法学会  2024.9  日本音楽療法学会

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    Event date： 2024.9

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：札幌  

  • 山下　薫   ７年間にわたる自律神経研究の過去・現在・未来ー臨床研究の意義と得られた知見の臨床応用   Invited

    第49回日本歯科麻酔学会総会・学術集会　シンポジウム１　匠の技を科学する臨床研究  2021.10  日本歯科麻酔学会

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    Event date： 2021.10

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：札幌（web開催）   Country：Japan  

  • 吉嶺秀星,　山下　薫, 四道瑠美,　杉村光隆   シミュレーターによる自主的トレーニングと指導員の口頭指導によるトレーニングがCPRの質の向上に与える影響  

    第11回日本シミュレーション医療教育学会  2023.10 

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    Event date： 2023.10

    Language：Japanese   Presentation type：Oral presentation (general)  

  • Akari Uto, Kaoru Yamashita, Shusei Yoshimine, Minako Uchino, Toshiro Kibe, Mitsutaka Sugimura   Autonomic nervous system activity during perioperative period of pediatric patients   International conference

    14th Annual Meeting of the Federation of Asian Dental Anesthesiology Societies,  2023.10  the Federation of Asian Dental Anesthesiology Societies

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    Event date： 2023.10

    Language：English   Presentation type：Poster presentation  

    Venue：Nagasaki   Country：Japan  

  • Kaoru Yamashita, Shusei Yoshimine, Akari Uto, Minako Uchino, Toshiro Kibe, Mitsutaka   Effect of local anesthesia at the bone collection site of iliac bone grafting on autonomic nervous system activity and circulatory dynamics in the treatment of patients with alveolar cleft   International conference

    14th Annual Meeting of the Federation of Asian Dental Anesthesiology Societies  2023.10  the Federation of Asian Dental Anesthesiology Societies,

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    Event date： 2023.10

    Language：English   Presentation type：Poster presentation  

    Venue：Nagasaki   Country：Japan  

  • Shusei Yoshimine, Kaoru Yamashita, Akari Uto, Minako Uchino, Toshiro Kibe, Mitsutaka Sugimura   A case report of heart rate variability record during the onset of vasovagal reflex   International conference

    14th Annual Meeting of the Federation of Asian Dental Anesthesiology Societies  2023.10  he Federation of Asian Dental Anesthesiology Societies

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    Event date： 2023.10

    Language：English   Presentation type：Poster presentation  

    Venue：Nagasaki   Country：Japan  

  • 宇都 明莉, 山下 薫, 岐部 俊郎, 内野 美菜子, 吉嶺 秀星, 杉村 光隆   小児患者の周術期における自律神経活動・循環動態・心理状態の変化  

    第50回日本歯科麻酔学会総会・学術集会  2022.10 

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    Event date： 2022.10

  • 山下 薫, 岐部俊郎, 内野　美菜子, 宇都明莉, 吉嶺秀星, 四道瑠美, 杉村光隆   State Anxiety Inventoryは下顎埋伏智歯抜歯前の患者の自律神経活動予測に有用である.  

    2022.10 

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    Event date： 2022.10

  • 祐德 美耀子，山下 薫，比嘉 憂理奈，橋口 浩平，白川 由紀恵，大野 幸，糀谷 淳，杉村 光隆.   静脈内鎮静法下での抜歯中に ST 低下を認め，冠攣縮性狭心症疑いと診断された 1 例.  

    第50回日本歯科麻酔学会総会・学術集会  2022.10 

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    Event date： 2022.10

  • 吉嶺 秀星, 山下 薫, 宇都 明莉, 内野 美菜子, 岐部 俊郎, 杉村 光隆   Modified Dental Anxiety Scaleの取得は歯科治療前の自律神経失調状態の評価に有用である,   Invited

    第50回日本歯科麻酔学会総会・学術集会  2022.10 

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    Event date： 2022.10

  • 四道 瑠美，糀谷 淳，山下 薫，大野 幸，杉村 光隆   心エコー図検査パラメータおよびバイオマーカーを用いた小~中程度侵襲手術後の異常高血圧発症リスクの評価.  

    第50回日本歯科麻酔学会総会・学術集会  2022.10 

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    Event date： 2022.10

  • 山下 薫, 吉嶺 秀星, 宇都 明莉, 比嘉 憂理奈, 四道 瑠美, 杉村 光隆   星状神経節ブロック時に発症した過換気発作ならびに血管迷走神経反射の回復後に呼吸抑制が持続した症例  

    第27回日本口腔顔面痛学会  2022.10 

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    Event date： 2022.10

    Venue：千葉  

  • 第50回日本歯科麻酔学会総会・学術集会  

    2022.10 

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    Event date： 2022.10

  • 宇都 明莉、山下 薫、内野 美菜子、岐部 俊郎、杉村 光隆   下顎埋伏智歯抜歯中の交感神経活動は処置前後の不安の変化と関連する  

    第49回日本歯科麻酔学会総会・学術集会   2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌（web)   Country：Japan  

  • 内野　美菜子、山下　薫、宇都明莉、岐部俊郎、杉村光隆   静脈内鎮静法が抜歯時の自律神経系と心理状態に与える影響  

    第49回日本歯科麻酔学会  2021.10  日本歯科麻酔学会

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    Event date： 2021.10

    Presentation type：Poster presentation  

    Venue：札幌（web)   Country：Japan  

  • 新納彩子、大野　幸、糀谷　淳、山下　薫、祐徳　美耀子、杉村光隆   心停止の既往を有しICD植え込み後で代謝性アルカローシスを来した発達障害患者に関する全身麻酔経験  

    第49回日本歯科麻酔学会総会・学術集会  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：札幌（web)   Country：Japan  

  • 白川由紀恵、大野　幸、山下　薫、杉村光隆   多剤抗パーキンソン病薬を服用している患者の観血的整復固定術に対する麻酔経験  

    第49回日本歯科麻酔学会総会・学術集会  2021.10  日本歯科麻酔学会

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    Event date： 2021.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：札幌（web)   Country：Japan  

  • 四道瑠美、糀谷　淳、大野　幸、山下　薫、杉村　光隆   歯科・口腔外科手術患者のバイオマーカーと左室拡張能・術後異常高血圧発症との関連  

    第49回日本歯科麻酔学会総会・学術集会  2021.10  日本歯科麻酔学会

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    Event date： 2021.10

    Presentation type：Poster presentation  

    Venue：札幌（web)   Country：Japan  

  • 四道　瑠美,　山下　薫,　内野　美菜子,　祐徳　美耀子,　白川　由紀恵, 　大原　由紀子,　宇都　明莉,　吉嶺　秀星, 　杉村　光隆   化学物質過敏症患者の抜歯、歯科治療時の静脈内鎮静法管理経験  

    2021.9  南九州歯学会

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    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：鹿児島   Country：Japan  

  • 岐部俊郎、石畑清秀、本庄希江、山下　薫、手塚征宏、渕上貴央、上栗　裕平、中村　典史   ビーグル犬における炭酸アパタイト骨補填材を用いた骨造成部位の後継永久歯自然萠出への影響の評価　予備的研究  

    日本口腔科学会総会・学術集会  2021.7  日本口腔科学会

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    Event date： 2021.7

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  • 山下 薫, 岐部俊郎, 四道瑠美, 糀谷 淳, 杉村光隆   エピネフリン添加リドカインとフェリプレシン添加プリロカインによる局所麻酔が自律神経系と循環動態に与える影響の評価　ランダム化比較試験  

    歯科麻酔学会 

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    Event date： 2020.10

    Language：Japanese   Presentation type：Poster presentation  

  • 四道瑠美, 糀谷 淳, 山下 薫, 大野 幸, 杉村光隆   歯科・口腔外科手術患者のバイオマーカー、左室拡張能・術後循環器系異常との関連  

    歯科麻酔学会 

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    Event date： 2020.10

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 小島佑貴, 山形和彰、千堂良造、山下　薫、大原由紀子、青山　歌奈絵、四道　瑠美、大野　幸、杉村　光隆   鹿児島大学病院歯科麻酔科・全身管理歯科治療部における新型コロナウイルス感染症対策について  

    歯科麻酔学会 

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    Event date： 2020.10

    Language：Japanese   Presentation type：Poster presentation  

  • 大野 幸, 青山　歌奈絵, 山下 薫,糀谷 淳, 杉村 光隆   口唇形成術を目的とした乳児における全身麻酔中の酸素化に影響を与える因子の検討  

    歯科麻酔学会 

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    Event date： 2020.10

    Language：Japanese   Presentation type：Poster presentation  

  • 吉野浩史, 岐部俊郎, 山下 薫, 渕上貴央, 手塚征宏, 中村典史   顎裂部腸骨海綿骨移植術における、術後悪心・嘔吐と摂食回復期間との関連  

    第31回小児口腔外科学会 

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    Event date： 2019.11

    Language：English   Presentation type：Poster presentation  

  • 青山歌奈絵, 山下 薫, 岐部俊郎   グレン循環患児における口唇形成術に対する全身麻酔経験   International conference

    第31回小児口腔外科学会 

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    Event date： 2019.11

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 山下 薫, 岐部俊郎, 大野 幸, 糀谷 淳, 杉村光隆   歯科治療中の神経学的評価モデルの確立-下顎埋伏智歯抜歯中の音楽介入は自律神経系と心理状態に影響を与える-  

    第47回日本歯科麻酔学会学術集会 

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    Event date： 2019.10

    Language：Japanese   Presentation type：Poster presentation  

  • 四道瑠美, 糀谷 淳, 山下 薫, 大野 幸, 杉村光隆   歯科・口腔外科手術患者のバイオマーカー、加速度脈波加齢指数と左室拡張能および術後循環器系異常との関連  

    第47回日本歯科麻酔学会学術集会 

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    Event date： 2019.10

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 千堂　良三, 山口　孝二郎, 真鍋　庸三, 山形　和彰, 山下　薫, 杉村　光隆   不眠症に対してエチゾラム内服をしていた舌痛症および口腔乾燥症患者に漢方両方が奏功した症例  

    口腔顔面痛学会 

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    Event date： 2019.9

    Language：Japanese   Presentation type：Poster presentation  

  • 山下 薫, 糀谷 淳, 宮田 昌明, 大野 幸, 遠矢 明菜, 大石 充, 杉村光隆   術前の歯科・口腔外科手術後の血圧異常の関連について  

    鹿児島麻酔懇話会 

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    Event date： 2019.3

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 糀谷　淳、山下　薫、大野　幸、遠矢明菜、眞鍋庸三、杉村光隆   加速度脈波のc/aと麻酔深度の相関について  

    第29回　九州歯科麻酔シンポジウム 

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    Event date： 2019.2

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 山下　薫   下顎埋伏智歯抜歯が自律神経系と心理状態に与える影響  

    第11回口腔先端科学教育研究センター研究発表会 

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    Event date： 2018.12

    Language：Japanese   Presentation type：Oral presentation (general)  

  • Yamashita K, Kibe T, Sugimura M   Relationship between anesthesia types and postoperative quality of life after iliac crest bone grafting of the alveolar cleft   International conference

    IFDAS 

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    Event date： 2018.10

    Language：English   Presentation type：Poster presentation  

  • 真鍋 庸三, 山下 薫, 千堂 良造, 遠矢 明菜, 山形 和彰, 糀谷 淳, 杉村 光隆   直線偏光近赤外線の星状神経節近傍照射が心臓自律神経系に与える影響  

    口腔顔面痛学会 

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    Event date： 2018.7

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 千堂 良造, 杉村 光隆, 糀谷 淳, 眞鍋 庸三, 山形 和彰, 山下 薫, 後藤 哲哉   ラット三叉神経節における組織透明化の応用と細胞体局在の検討  

    口腔顔面痛学会 

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    Event date： 2018.7

    Language：Japanese   Presentation type：Poster presentation  

  • 糀谷 淳, 宮田 昌明, 山下 薫, 四道 瑠美, 大石 充, 杉村 光隆   術前の左室拡張機能と、歯科・口腔外科手術後の血圧異常の関連について  

    日本高血圧学会臨床高血圧フォーラムプログラム 

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    Event date： 2018.5

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 三島 優美子, 後藤 雄一, 別府 真広, 山下 薫, 濱田 倫史, 坂元 亮一, 今村 晴幸, 杉村 光隆, 杉浦 剛   口腔癌術治療時に著明な低ナトリウム血症を認め診断治療に苦慮した2例  

    口腔科学会 

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    Event date： 2018.5

    Language：Japanese   Presentation type：Poster presentation  

  • 高橋 美菜子, 糀谷 淳, 大野 幸, 佐古 沙織, 山下 薫, 杉村 光隆   術前の左室拡張機能と歯科・口腔外科手術後の循環器系合併症の関連について　多項ロジスティック回帰分析を用いたリスク因子の同定  

    歯科麻酔学会 

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    Event date： 2017.10

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 山下 薫, 岐部 俊郎, 杉村 光隆   亜酸化窒素吸入鎮静法と音楽聴取の併用が脳波・自律神経活動と心理状態に与える影響  

    歯科麻酔学会 

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    Event date： 2017.10

    Language：Japanese   Presentation type：Oral presentation (general)  

  • Yamashita K, Kibe T, Sugimura M   Effect for autonomic nervous system and psychological condition by the combination of nitrous oxide inhalation sedation and listening to music.   International conference

    International Society for Autonomic Neuroscience 

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    Event date： 2017.9

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 山下　薫   亜酸化窒素吸入鎮静法と音楽聴取の併用による脳波・自律神経コントロール法の確立  

    第9回口腔先端科学教育研究センター研究発表会 

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    Event date： 2016.12

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 大野 幸, 糀谷 淳, 山下 薫, 杉村 光隆   術前の左室拡張機能と口腔外科手術後の循環器系合併症の関連について  

    歯科麻酔学会 

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    Event date： 2016.10

    Language：Japanese   Presentation type：Poster presentation  

  • 是枝 清孝, 大野 幸, 山下 薫, 千堂 良造, 遠矢 明菜, 岐部 俊郎, 真鍋 庸三, 糀谷 淳, 杉村 光隆   静脈内鎮静法におけるRoot(Sed-Line+Radical-7)の使用経験  

    歯科麻酔学会 

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    Event date： 2016.10

    Language：Japanese   Presentation type：Poster presentation  

  • 糀谷 淳, 大野 幸, 遠矢 明菜, 山下 薫, 真鍋 庸三, 杉村 光隆   左室拡張機能と加速度脈波パラメータ群の関係について  

    歯科麻酔学会 

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    Event date： 2016.10

    Language：Japanese   Presentation type：Poster presentation  

  • 糀谷 淳, 山下 薫, 宮田 昌明, 大石 充, 杉村 光隆   全身麻酔下で行った中程度侵襲手術の周術期における血管内皮機能の推移  

    日本高血圧学会総会 

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    Event date： 2016.9

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 是枝 清孝, 眞鍋 庸三, 千堂 良造, 山下 薫, 遠矢 明菜, 大野 幸, 糀谷 淳, 椙山 加綱   男女別に算出した経鼻挿管時のチューブ固定長予測式  

    歯科麻酔学会 

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    Event date： 2015.10

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 山下 薫, 眞鍋 庸三, 大野 幸, 遠矢 明菜, 是枝 清孝, 千堂 良造, 糀谷 淳, 椙山 加綱   亜酸化窒素吸入とイージーリスニング音楽が自律神経機能に及ぼす影響  

    歯科麻酔学会 

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    Event date： 2015.10

    Language：Japanese   Presentation type：Oral presentation (general)  

  • Yamashita Kaoru, Yoshimine Shusei, Uto Akari, Uchino Minako, Kibe Toshiro, Sugimura Mitsutaka   顎裂患者の治療における腸骨移植骨採取部位の局所麻酔が自律神経系活動および循環動態に及ぼす影響(Effect of local anesthesia at the bone collection site of iliac bone grafting on autonomic nervous system activity and circulatory dynamics in the treatment of patients with alveolar cleft)  

    日本歯科麻酔学会雑誌  2023.9  (一社)日本歯科麻酔学会

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    Language：English  

  • 内野 美菜子, 山下 薫, 岐部 俊郎, 宇都 明莉, 四道 瑠美, 糀谷 淳, 杉村 光隆   静脈内鎮静法が抜歯時の自律神経系と心理状態に与える影響  

    日本歯科麻酔学会雑誌  2021.9  (一社)日本歯科麻酔学会

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    Language：Japanese  

  • 宇都 明莉, 山下 薫, 岐部 俊郎, 内野 美菜子, 吉嶺 秀星, 杉村 光隆   小児患者の周術期における自律神経活動・循環動態・心理状態の変化  

    日本歯科麻酔学会雑誌  2022.9  (一社)日本歯科麻酔学会

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    Language：Japanese  

  • 山下 薫   匠の技を科学する臨床研究　7年間にわたる自律神経研究の過去・現在・未来　臨床研究の意義と得られた知見の臨床応用  

    日本歯科麻酔学会雑誌  2021.9  (一社)日本歯科麻酔学会

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    Language：Japanese  

  • 宇都 明莉, 山下 薫, 内野 美菜子, 岐部 俊郎, 杉村 光隆   下顎埋伏智歯抜歯中の交感神経活動は処置前後の不安の変化と関連する  

    日本歯科麻酔学会雑誌  2021.9  (一社)日本歯科麻酔学会

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    Language：Japanese  

  • 岐部 俊郎, 石畑 清秀, 本庄 希江, 山下 薫, 手塚 征宏, 渕上 貴央, 上栗 裕平, 中村 典史   ビーグル犬における炭酸アパタイト骨補填材を用いた骨造成部位の後継永久歯自然萠出への影響の評価　予備的研究  

    日本口腔科学会雑誌  2021.7  (NPO)日本口腔科学会

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    Language：Japanese  

  • 山下 薫, 岐部 俊郎, 内野 美菜子, 宇都 明莉, 吉嶺 秀星, 四道 瑠美, 杉村 光隆   State Anxiety Inventoryは下顎埋伏抜歯前の患者の自律神経活動予測に有用である  

    日本歯科麻酔学会雑誌  2022.9  (一社)日本歯科麻酔学会

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    Language：Japanese  

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Awards

  • 日本音楽療法学会第４回日野原賞　受賞

    2024.7   日本音楽療法学会  

  • 鹿児島銀行公益社団法人　かぎん文化財団賞

    2024.6   鹿児島銀行公益社団法人　かぎん文化財団  

  • ベストリサーチャー賞

    2021.12   鹿児島大学歯学部  

  • 令和２年度　鹿児島大学歯学部同窓会奨励賞

    2020.11   鹿児島大学　歯学部　同窓会  

    山下　薫

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    Award type：International academic award (Japan or overseas)  Country：Japan

  • 鹿児島大学大学院　医歯学奨励賞

    2019.6   鹿児島大学大学院　医歯学総合研究科  

    山下　薫

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    Country：Japan

  • 鹿児島大学進取の精神チャレンジプログラム　優秀賞

    2018.2   鹿児島大学  

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Research Projects

  • 聴性誘発電位と脳波の解析による新規全身麻酔薬レミマゾラムの麻酔深度評価法の検討

    2024.5 - 2026.4

    日本歯科麻酔学会  日本歯科麻酔学会若手研究助成 

    山下　薫

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\500000 （ Direct Cost: \500000 ）

  • 漢方薬がオーラルフレイルに与える影響の解明

    2022.4 - 2025.3

    科学研究費補助金  基盤研究(C) 分担

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    Grant type：Competitive

  • 聴覚を介した自律神経変動の管理による高血圧患者の安全な歯科治療環境の創造

    2021.4 - 2024.3

    科学研究費補助金  科学研究費　若手研究

    山下　薫

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    Grant type：Competitive

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

  • 三叉神経領域の痛覚日内変動機構の解明

    2020.4 - 2024.3

    科学研究費補助金  基盤研究(C)

  • バイオマーカー、心拍変動解析および加速度脈波を用いた左室拡張機能の推定法の確立

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

  • 聴覚を介する自律神経制御法の確立ー時計遺伝子欠損マウスでの検討と臨床応用ー

    2018.4 - 2021.3

    科学研究費補助金  若手研究(B)

  • 三叉神経領域の痛覚日内変動機構の解明　– 効果的な時間薬物療法の確立に向けて –

    2016.4

    科学研究費補助金  基盤研究(C)

  • 左室拡張能、圧受容体反射感受性とバイオマーカーによる術後心血管リスク因子の同定

    2016.4

    科学研究費補助金  基盤研究(C)

  • 血管内皮機能と指尖容積脈波からみた理想的な全身麻酔法の開発研究

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

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Teaching Experience

  • 歯科麻酔学１、歯科麻酔学２