Updated on 2024/02/19

写真a

 
HARADA Kae
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Oral and Maxillofacial Rehabilitation Assistant Professor
Title
Assistant Professor
External link

Degree

  • Doctor of Philosophy, Doctor of Dental Science ( 2004.3   Kyushu University )

  • Bachelor of Dental Science ( 2000.3   Kyushu University )

Research Interests

  • Prosthetic Dentistry

  • Denture Care

  • Bone Regeneration

  • Denture Cleaners (Denture Cleansers)

  • Bacterial infection

  • Autophagy

  • Oral Health Care

  • Senescence and aging

  • Prosthodontic Dentistry

  • 細胞生物学

  • Studies on celluar signaling mechanisms

Research Areas

  • Life Science / Prosthodontics

Education

  • Kyushu University   Graduate School of f Dental Science

    2000 - 2004

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    Country: Japan

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  • Kyushu University   School of Dentistry

    1994 - 2000

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    Country: Japan

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Research History

  • Kagoshima University Hospital   Hospital

    2019.7

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  • Kagoshima University   Department of Oral and Maxillofacial Prosthodontics, Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course , Research Field in Dentistry, Medical and Dental Sciences Area, Graduate School of Medical and Dental Sciences   Assistant Professor

    2016.4

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    Country:Japan

  • Kagoshima University   Assistant Professor

    2016.4

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  • Hiroshima University   Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences   Assistant Professor

    2009.4 - 2016.3

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    Country:Japan

  • Hiroshima University Hospital   Department of Prosthetic Dentistry   Clinical Staff

    2006.4 - 2009.3

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    Country:Japan

  • Hiroshima University Hospital   Department of Prosthetic Dentistry   Resident

    2004.4 - 2006.3

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    Country:Japan

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Committee Memberships

  • 日本補綴歯科学会   九州支部 会計幹事  

    2017.6 - 2019.5   

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    Committee type:Academic society

Qualification acquired

  • 日本補綴歯科学会 専門医

  • 日本老年歯科医学会 認定医

  • 臨床能力試験臨床実地試験評価者

  • 臨床能力試験一斉技能試験認定評価者

  • 臨床研修指導歯科医

  • Dentist

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Papers

  • Kae Harada, Reiya Horinouchi, Mamoru Murakami, Yusuke Yamashita, Takahiro Yanagisawa, Naohiro Shimotahira, Yuji Kamashita, Taizo Hamada, Yasuhiro Nishi, Masahiro Nishimura .  An in vitro study on the selection of surfactants for removal of cream denture adhesives from dentures and their application to denture cleaners .  Journal of Prosthodontic Research   2023.4Reviewed

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Prosthodontic Society  

    PURPOSE: Denture adhesives improve the stability of incompatible dentures; however, complete removal of adhesives after use is difficult. Only a few studies have focused on the removal of denture adhesives. Hence, this study aimed to assess the efficacy of surfactants in removing cream denture adhesives from acrylic resin materials. METHODS: Solutions of twelve surfactants with various hydrophilic-lipophilic balance (HLB) values were prepared. Two cream denture adhesives, colored for visualization, were spread onto transparent acrylic resin plates. After immersion into surfactant solutions, the effects of the surfactants on residual adhesives were evaluated. We also investigated the effect of denture cleaners (with or without the surfactants) on the removability of adhesives and artificial oily dirt, and their effects on the surface properties of denture materials. The obtained data were analyzed using appropriate statistical methods. RESULTS: Five surfactants [BT-5, BL-4.2, BT-7, BT-9, and Triton X-100 (TX)] with HLB values in the 10.5-13.5 range effectively removed adhesives. Addition of BT-9 and TX (HLB=13.5) to denture cleaners improved the adhesives' removal. Furthermore, the addition of TX to the cleaners did not interfere with the removal of artificial oily dirt and did not damage the denture materials' surface. CONCLUSION: Surfactants with HLB values in the 10.5-13.5 range are suitable for removal of cream denture adhesives from acrylic resin materials. In particular, TX (HLB=13.5) efficiently removes adhesives without damaging denture materials or impairing original detergency.

    DOI: 10.2186/jpr.jpr_d_21_00286

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  • 原田佳枝 .  新義歯製作と口腔機能訓練を併用し口腔機能改善を図った症例 .  日本補綴歯科学会誌15 ( 4 ) 579 - 582   2023.10Reviewed

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    DOI: https://doi.org/10.2186/ajps.15.579

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  • Yuka Inamochi, Yoichiro Ogino, Kae Harada, Kenji Fueki, Yasunori Ayukawa, Masahiro Nishimura, Kenji Maekawa, Youngnam Kang, Toshihiro Hirai, Takuo Kuboki .  Do oral care and rehabilitation improve cognitive function? A systematic review of clinical studies .  Journal of Evidence-Based Dental Practice   101948 - 101948   2023.10

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.jebdp.2023.101948

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  • Kae Harada, Yasuhiro Nishi, Masahiro Nishimura .  A Case of Improved Oral Functions Following Oral Function Training for a Patient with Submandibular Gland Excision .  Japanese Journal of Gerodontology38 ( supplement ) 9 - 13   2023.7Reviewed

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11259/jsg.38.supplement_9

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  • Yasuhiro Nishi, Katsura Seto, Mamoru Murakami, Kae Harada, Masakazu Ishii, Yuji Kamashita, Shinichiro Kawamoto, Tohru Hamano, Takuya Yoshimura, Asutsugu Kurono, Yasunori Nakamura, Masahiro Nishimura .  Effects of Denture Cleaning Regimens on the Quantity of Candida on Dentures: A Cross-Sectional Survey on Nursing Home Residents .  International Journal of Environmental Research and Public Health19 ( 23 ) 15805 - 15805   2022.11Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    Oral care involving a denture cleaning regimen is important for reducing the incidence of systemic diseases. However, limited information is currently available on denture cleaning frequencies and regimens. Therefore, the present study investigated the relationship between the number of Candida spp. present on the complete dentures of nursing home residents and cleaning regimens. Residents were surveyed to assess their denture cleaning methods. Plaque was collected by applying a sterile swab to the mucosal surface of each examined complete denture worn by 77 residents, and the Candida spp. collected were cultured, identified, and quantified. The relationship between denture cleaning regimens and the quantity of Candida spp. was investigated. Correlation and multivariable analyses revealed that the strongest factor influencing the number of Candida spp. on dentures was the frequency of use of denture cleansers. The number of Candida spp. was the lowest on dentures cleaned daily with a denture cleanser. The present results demonstrated that the daily use of a denture cleanser effectively controlled the adherence of Candida spp. to dentures. Oral and other healthcare providers need to provide instructions on and assist nursing home residents with the daily care of dentures, using denture cleansers, including the environment where cleaning is performed.

    DOI: 10.3390/ijerph192315805

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  • Horinouchi R, Harada K, Murakami M, Yamashita Y, Kamashita Y, Shimotahira N, Hamada T, Nishi Y, Nishimura M .  Properties and characteristics of foam denture cleaners as denture adhesive removers .  Dental Materials Journal41 ( 5 ) 741 - 748   2022.6Reviewed International journal

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Dental Materials and Devices  

    The need for denture adhesives is increasing worldwide, but few denture-care products target denture adhesive users. Foam denture cleaners have been recently marketed to assist brush denture cleaning, but there is a lack of objective evaluation. In this study, we compared the detergency of denture adhesives using six commercial foam-denture cleaners. For removing the adhesives, most of the tested cleaners were effective in immersion experiments, and three cleaners were more effective in the denture cleaning experiment compared to control water. However, only one could effectively remove the slime that is derived from the adhesive and detergency of artificial dirt. The surface roughnesses of the denture base and the relining material revealed that prolonged immersion in some cleaners could be affected. The results suggest that different commercial foam denture cleaners have different detergency levels, and that some cleaners may affect the properties of denture materials upon long-term use.

    DOI: 10.4012/dmj.2022-007

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  • Yamashita Y, Nishi Y, Murakami M, Harada K, Nishimura M .  Impact of surface changes and microbial adhesion on mucosal surface finishing of resin denture bases by shot blast polishing using viscoelastic media .  Materials (Basel, Switzerland) 15 ( 6 )   2022.3Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    Surface changes and microbiological effects following shot blast polishing with viscoelastic media of the mucosal surface of resin denture bases were examined. Average surface roughness (Ra) and the depth of surface removal of specimens were measured over time, and the clinical number of microbial adhesions on the mucosal surface of dentures was clinically assessed. The results obtained showed no changes in Ra after 20 s of polishing, Ra of <0.2 µm, and a depth of surface removal < 20 µm. This method of finishing did not affect the fit of the mucosal surface of the dentures. Furthermore, the adhesion of microorganisms to the mucosal surface of dentures was significantly suppressed. Shot blast polishing with viscoelastic media is useful for finishing the mucosal surface of resin denture bases.

    DOI: 10.3390/ma15062275

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  • Murakami M, Harada K, Nishi Y, Shimizu T, Motoyama S, Nishimura M .  Effects of storage temperature and pH on the antifungal effects of commercial oral moisturizers against Candida albicans and Candida glabrata .  Medicina (Lithuania) 56 ( 10 ) 1 - 12   2020.10Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/medicina56100525

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  • Murakami M, Nishi Y, Harada K, Masuzaki T, Minemoto Y, Yanagisawa T, Shimizu T, Tsuboi A, Hamada T, Nishimura M .  Impact of oral intake of glucosylceramide extracted from pineapple on xerostomia: a double-blind randomized cross-over trial .  Nutrients 11 ( 9 ) 2020 - 2020   2019.8Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    Background: The aim of this double-blind randomized cross-over trial was to evaluate the effect of oral intake of glucosylceramide extracted from pineapple on oral moisture and xerostomia symptoms. Methods: Sixteen participants who had xerostomia symptoms were randomly allocated into two groups. One group received, as test samples, tablets containing glucosylceramide extracted from pineapple (GCP) followed by placebo tablets. The other group received the test samples in the reverse order. Participants were instructed to take tablets of the first test sample once a day (after breakfast) for two consecutive weeks. Then, after a washout period of four weeks, participants were instructed to take the other test sample for two consecutive weeks. The oral moisture level of the lingual mucosa, xerostomia symptoms, and the number of fungiform papillae was evaluated. Results: The oral moisture significantly increased, and the visual analog scale (VAS) of “How is the dryness of your mouth?” significantly improved after GCP tablets intake and not after placebo tablets intake. The number of fungiform papillae was not significantly different following the intake of GCP tablets or placebo tablets. Conclusion: Results suggested that oral intake of GCP may improve the moisture level and xerostomia symptoms.

    DOI: 10.3390/nu11092020

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  • Kanematsu T, Oue K, Okumura T, Harada K, Yamawaki Y, Asano S, Mizokami A, Irifune M, Hirata M .  Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure .  Journal of Oral Biosciences 61 ( 2 ) 65 - 72   2019.5Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditureReviewed International journal

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    Publisher:The Japanese Association for Oral Biology  

    DOI: 10.1016/j.job.2019.04.002

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  • Hayashiuchi M, Kitayama T, Morita K, Yamawaki Y, Oue K, Yoshinaka T, Asano S, Harada K, Kang Y, Hirata M, Irifune M, Okada M, Kanematsu T .  General anesthetic actions on GABAA receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice .  Journal of Anesthesia 31 ( 4 ) 531 - 538   2017.8Reviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER JAPAN KK  

    The aim of this study was to investigate the action of general anesthetics in phospholipase C-related catalytically inactive protein (PRIP)-knockout (KO) mice that alter GABA(A) receptor signaling.
    PRIP regulates the intracellular trafficking of beta subunit-containing GABA(A) receptors in vitro. In this study, we examined the effects of intravenous anesthetics, propofol and etomidate that act via beta subunit-containing GABA(A) receptors, in wild-type and Prip-KO mice. Mice were intraperitoneally injected with a drug, and a loss of righting reflex (LORR) assay and an electroencephalogram analysis were performed.
    The cell surface expression of GABA(A) receptor beta 3 subunit detected by immunoblotting was decreased in Prip-knockout brain compared with that in wild-type brain without changing the expression of other GABA(A) receptor subunits. Propofol-treated Prip-KO mice exhibited significantly shorter duration of LORR and had lower total anesthetic score than wild-type mice in the LORR assay. The average duration of sleep time in an electroencephalogram analysis was shorter in propofol-treated Prip-KO mice than in wild-type mice. The hypnotic action of etomidate was also reduced in Prip-KO mice. However, ketamine, an NMDA receptor antagonist, had similar effects in the two genotypes.
    PRIP regulates the cell surface expression of the GABA(A) receptor beta 3 subunit and modulates general anesthetic action in vivo. Elucidation of the involved regulatory mechanisms of GABA(A) receptor-dependent signaling would inform the development of safer anesthetic therapies for clinical applications.

    DOI: 10.1007/s00540-017-2350-2

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  • Asano S, Taniguchi Y, Yamawaki Y, Gao J, Harada K, Takeuchi H, Hirata M, Kanematsu T .  Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signaling .  Scientific Reports 7 ( 1 )   2017.7Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signalingReviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Nature Limited  

  • Harada-Hada K, Mimura S, Hong G, Hashida T, Abekura H, Murata H, Nishimura M, Nikawa H .  Accelerating effects of cellulase in the removal of denture adhesives from acrylic denture bases .  Journal of Prosthodontic Research 61 ( 2 ) 185 - 192   2017.4Accelerating effects of cellulase in the removal of denture adhesives from acrylic denture basesReviewed International journal

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    Purpose: Studies of effective methods for the easy removal of denture adhesives from a denture base are not well represented in the literature. We previously assessed the removability of denture adhesives by immersing within denture cleaners, showing that some cleaners have a weak effect, insufficiently effective in daily use. In this study, we prepared a cellulase, as a potential component for denture adhesive removers, and we examined whether the addition of cellulase to denture cleaners is effective in the removal of cream denture adhesives.
    Methods: We prepared the cellulase Meicelase as one component for the liquefaction of denture adhesives. We used two denture cleaners and two cream adhesives. After the immersion of plates in sample solutions, we evaluated the area of the sample plate still covered with adhesives. Biofilm removal assay was also performed using denture cleaners containing cellulase.
    Results: The addition of cellulase accelerated the removal of cream adhesives in immersion experiments to a rate faster than that of water and denture cleaners. However, it did not influence the removability of Candida albicans biofilms from acrylic resin specimens.
    Conclusion: Cellulase hastened the liquefaction of cream adhesives. (C) 2016 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jpor.2016.06.004

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  • Yamawaki Y, Oue K, Shirawachi S, Asano S, Harada K, Kanematsu T .  Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation .  Japanese Dental Science Review 53 ( 1 ) 18 - 24   2017.2Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammationReviewed International journal

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    Publisher:Elsevier Ltd  

    Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol. Prevention and control of obesity is complex, and requires a multifaceted approach. The elucidation of molecular mechanisms driving fat metabolism (adipogenesis and lipolysis) aims at developing clinical treatments to control obesity. We recently reported a new regulatory mechanism in fat metabolism: a protein phosphatase binding protein, phospholipase C-related catalytically inactive protein (PRIP), regulates lipolysis in white adipocytes and heat production in brown adipocytes via phosphoregulation. Deficiency of PRIP in mice led to reduced fat accumulation and increased energy expenditure, resulting in a lean phenotype. Here, we evaluate PRIP as a new therapeutic target for the control of obesity.

    DOI: 10.1016/j.jdsr.2016.06.001

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  • Harada-Hada K, Hong G, Abekura H, Murata H .  Evaluation of the efficiency of denture cleaners for removing denture adhesives .  Gerodontology 33 ( 4 ) 453 - 460   2016.12Evaluation of the efficiency of denture cleaners for removing denture adhesivesReviewed International journal

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:John Wiley & Sons, Inc.  

    DOI: 10.1111/ger.12183

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  • Oue K, Zhang J, Harada-Hada K, Asano S, Yamawaki Y, Hayashiuchi M, Furusho H, Takata T, Irifune M, Hirata M, Kanematsu T .  Phospholipase C-related catalytically inactive protein is a new modulator of thermogenesis promoted by β-adrenergic receptors in brown adipocyte .  Journal of Biological Chemistry 291 ( 8 ) 4185 - 4196   2016.2Phospholipase C-related catalytically inactive protein is a new modulator of thermogenesis promoted by β-adrenergic receptors in brown adipocyteReviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Society for Biochemistry and Molecular Biology  

    DOI: 10.1074/jbc.M115.705723

  • Harada-Hada K and Kanematsu T .  Molecular basis involved in autophagy-mediated clearance of intracellular pathogens .      35 - 37   2015.10Molecular basis involved in autophagy-mediated clearance of intracellular pathogens

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  • Okumura T, Harada K, Oue K, Zhang J, Asano S, Hayashiuchi M, Mizokami A, Tanaka H, Irifune M, Kamata N, Hirata M, Kanematsu T .  Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase .  PLoS One 9 ( 6 )   2014.7Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipaseReviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PLOS  

    DOI: 10.1371/journal.pone.0100559

  • Harada-Hada K, Harada K, Kato F, Hisatsune J, Tanida I, Ogawa M, Asano S, Sugai M, Hirata M, Kanematsu T .  Phospholipase C-related catalytically inactive protein participates in the autophagic elimination of Staphylococcus aureus infecting mouse embryonic fibroblasts .  PLoS One 9 ( 5 )   2014.5Phospholipase C-related catalytically inactive protein participates in the autophagic elimination of Staphylococcus aureus infecting mouse embryonic fibroblastsReviewed International journal

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:PLOS  

    DOI: 10.1371/journal.pone.0098285

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  • Asano S, Nemoto T, Kitayama T, Harada K, Zhang J, Harada K, Tanida I, Hirata M, Kanematsu T .  Phospholipase C-related catalytically inactive protein (PRIP) controls KIF5B-mediated insulin secretion .  Biology Open 3 ( 6 ) 463 - 474   2014.5Phospholipase C-related catalytically inactive protein (PRIP) controls KIF5B-mediated insulin secretionReviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/bio.20147591

  • Umebayashi H, Mizokami A, Matsuda M, Harada K, Takeuchi H, Tanida I, Hirata M, Kanematsu T .  Phospholipase C-related catalytically inactive protein, a novel microtubule-associated protein 1 light chain 3-binding protein, negatively regulates autophagosome formation .  Biochemical and Biophysical Research Communications 432 ( 2 ) 268 - 74   2013.3Phospholipase C-related catalytically inactive protein, a novel microtubule-associated protein 1 light chain 3-binding protein, negatively regulates autophagosome formationReviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier B.V.  

    DOI: 10.1016/j.bbrc.2013.01.119

  • 小野重弘、武知正晃、原田佳枝、太田耕司、奥村俊哉、香川和子、安部倉 仁、奥井 岳、二宮嘉昭、高本 愛、赤川安正、鎌田伸之 .  異常絞扼反射を呈する上下無歯顎患者に対してインプラントにより咬合再建を行った 1 例 .  広島大学歯学会雑誌43 ( 1 ) 57 - 60   2011.6異常絞扼反射を呈する上下無歯顎患者に対してインプラントにより咬合再建を行った 1 例Reviewed

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  • 原田佳枝、牧平清超、二川浩樹、小川郁子、北川雅恵、安部倉仁、西村正宏、栗原英見、赤川安正、濱田泰三 .  異汗性湿疹の手指症状が口腔内金属の除去治療により緩和された症例 .  日本口腔検査学会雑誌1 ( 1 )   2009.3異汗性湿疹の手指症状が口腔内金属の除去治療により緩和された症例Reviewed

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  • Makihira S, Mizumachi W, Harada K, Shimoe S, Sadamori S, Nikawa H .  The pre-surgical modification of the provisional over-denture through 3-dimensional image analysis supports the mini dental implant treatment: A clinical report .  Int Chin J Dent8 ( 83 ) 39 - 42   2008.9The pre-surgical modification of the provisional over-denture through 3-dimensional image analysis supports the mini dental implant treatment: A clinical report Reviewed International journal

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  • Harada K, Takeuchi H, Oike M, Matsuda M, Kanematsu T, Yagisawa H, Nakayama KI, Maeda K, Erneux C, Hirata M .  Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3-mediated Ca2+ signaling .  Journal of Cellular Physiology 202 ( 2 ) 422 - 433   2005.2Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3-mediated Ca2+ signalingReviewed International coauthorship International journal

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:John Wiley & Sons, Inc.  

    DOI: 10.1002/jcp.20136

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  • Yoshimura K, Takeuchi H, Sato O, Hidaka K, Doira N, Terunuma M, Harada K, Ogawa Y, Ito Y, Kanematsu T, Hirata M. .  Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1α .  Journal of Biological Chemistry 276 ( 21 ) 17908 - 17913   2001.5Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1αReviewed International journal

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Society for Biochemistry and Molecular Biology  

    DOI: 10.1074/jbc.M009677200

    DOI: 10.1074/jbc.M009677200

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Books

  • 別冊 ザ・クインテッセンス YEARBOOK 2024 患者説明にも自信がつく 今はこうする・こう考える 義歯のケア

    村田比呂司, 市川哲雄, 猪原 健, 大久保力廣, 岡崎定司, 織田展輔, 片山 昇, 叶井里歩, 亀田行雄, 河相安彦, 川西範繁, 木本克彦, 木本 統, 洪 光, 今 一裕, 近藤尚知, 新保秀仁, 五月女さき子, 武部 純, 坪井明人, 西村正宏, 濵 洋平, 原田佳枝, 藤本篤士, 星 憲幸, 松田謙一, 松村香織, 水口俊介, 谷田部 優, 吉田光由, 米山喜一, 渡部 守

    2024.1 

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MISC

  • エビデンスに基づいてデンチャープラークを徹底除去! 義歯の正しいケアの仕方

    西 恭宏, 原田 佳枝, 西村 正宏

    日本歯科評論   81 ( 9 )   99 - 110   2021.9

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    Language:Japanese   Publisher:(株)ヒョーロン・パブリッシャーズ  

  • 臨床に役立つすぐれモノ 入れ歯洗浄剤「デントロクリーンムース」

    原田佳枝

    デンタルダイヤモンド   45 ( 7 )   158 - 162   2020.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:デンタルダイヤモンド社  

  • オートファジーによる細菌排除システム

    原田佳枝,兼松 隆

    広島歯科医学雑誌   43 ( 1 )   1 - 7   2016.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)   Publisher:広島県歯科医師会  

  • 義歯洗浄剤と超音波洗浄器を併用した洗浄方法とその洗浄温度が微生物除去効果に及ぼす影響

    西 恭宏, 原田 佳枝, 中村 康典

    日本口腔ケア学会雑誌   17 ( 3 )   195 - 195   2023.4

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  • 我が国における治療用義歯の臨床エビデンスに関するレビュー

    村上 格, 宮田 春香, 中西 悠梨香, 原田 佳枝, 西 恭宏, 西村 正宏

    日本補綴歯科学会誌   14 ( 九州支部学術大会特別号 )   55 - 55   2022.11

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  • 義歯安定剤使用者のための新しい泡タイプ義歯洗浄剤の開発

    原田佳枝, 堀之内玲耶, 村上 格, 下田平直大, 鎌下祐次, 山下裕輔, 西 恭宏, 西村正宏

    歯界展望 特別号   283   2022.5

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  • 患者特性からみた口腔機能低下症、サルコペニア、フレイルの関係

    西 恭宏, 山下 裕輔, 村上 格, 原田 佳枝, 益崎 与泰, 峰元 洋光, 堀之内 玲耶, 池田 菜緒, 中村 康典, 西村 正宏

    老年歯科医学   36 ( 2 )   140 - 141   2021.9

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  • 温度とpHは口腔保湿剤の抗真菌性に影響を及ぼす

    村上 格, 原田 佳枝, 元山 彩良, 西 恭宏, 西村 正宏

    老年歯科医学   36 ( 2 )   162 - 163   2021.9

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  • ショットブラストによるレジン床義歯粘膜面の表面性状と微生物付着状況の検討

    山下 裕輔, 西 恭宏, 村上 格, 原田 佳枝, 堀之内 玲耶, 西村 正宏

    日本歯科医師会雑誌   74 ( 4 )   475 - 475   2021.7

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  • Study on pH value of commercial oral moisturizers

    元山彩良, 村上格, 原田佳枝, 西恭宏, 西村正宏

    日本補綴歯科学会誌(Web)   13   2021

  • パイナップル由来セラミドの経口摂取は口腔乾燥を改善する 二重盲検無作為化交差試験

    村上 格, 西 恭宏, 原田 佳枝, 益崎 与泰, 峰元 洋光, 柳澤 嵩大, 西村 正宏

    日本補綴歯科学会誌   12 ( 特別号 )   267 - 267   2020.6

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  • 補綴外来患者における口腔機能低下症の下位症状と身体的フレイル指標の関連

    西恭宏, 山下裕輔, 村上格, 原田佳枝, 益崎与泰, 峰元洋光, 堀之内玲耶, 池田菜緒, 中村康典, 西村正宏

    日本老年歯科医学会学術大会(Web)   31st ( 4 )   126 - 126   2020

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  • 医療従事者における口腔保湿剤の認知度ならびに指導実態の調査

    村上 格, 西 恭宏, 原田 佳枝, 西村 正宏

    老年歯科医学   34 ( 2 )   225 - 225   2019.9

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  • 適正範囲のHLB値をもつ界面活性剤はクリームタイプ義歯安定剤除去にて有用である

    堀之内 玲耶, 原田 佳枝, 村上 格, 西 恭宏, 西村 正宏

    日本補綴歯科学会誌   11 ( 特別号 )   202 - 202   2019.5

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  • 顎骨骨髄由来間質細胞の骨形成能判定のためのマーカー探索

    駒走尚大, 末廣史雄, 石井正和, 柳澤嵩大, 原田佳枝, 西村正宏

    日本再生医療学会総会(Web)   18th   ROMBUNNO.P‐01‐043 (WEB ONLY)   2019

  • 舌苔付着の主観評価と舌背細菌数の関係

    新屋 俊明, 西 恭宏, 中村 康典, 村上 格, 原田 佳枝, 鎌下 祐次, 西村 正宏

    老年歯科医学   33 ( 2 )   154 - 155   2018.9

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  • 口腔保湿剤の保管温度と種類がその抗真菌性に及ぼす影響

    村上 格, 藤島 慶, 原田 佳枝, 西 恭宏, 西村 正宏

    日本補綴歯科学会誌   10 ( 特別号 )   187 - 187   2018.6

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  • 口腔インプラント専門外来におけるインプラントオーバーデンチャーの経過報告について

    下田平 直大, 末廣 史雄, 藤島 慶, 原田 佳枝, 益崎 与泰, 西 恭宏, 西村 正宏

    日本口腔インプラント学会誌   30 ( 3 )   E188 - E189   2017.9

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  • 義歯安定剤使用者のための新しい義歯洗浄剤の開発

    原田 佳枝, 三村 純代, 洪 光, 安部倉 仁, 二川 浩樹, 西村 正宏

    日本補綴歯科学会誌   9 ( 特別号 )   178 - 178   2017.6

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  • 顎骨再生を目的とした顎骨骨髄間質細胞培養法の開発

    末廣 史雄, 藤島 慶, 益崎 与泰, 原田 佳枝, 柳澤 嵩大, 西村 正宏

    日本補綴歯科学会誌   9 ( 特別号 )   267 - 267   2017.6

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  • PRIPはnon-professional phagocytesにおいてオートファジーによる感染細菌排除機構を調節する

    原田 佳枝, 兼松 隆

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 88回・38回   2P0062   2015.12

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  • Salmonella Typhimuriumの細胞内増殖はPLC-related catalytically inactive proteinによるオートファジー調節により抑制される

    原田 佳枝, 兼松 隆

    Journal of Oral Biosciences Supplement 2015   209   2015.9

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  • 脱リン酸化制御による脂肪分解の新たな分子基盤 Reviewed

    大植香菜、原田佳枝、兼松 隆

    日本薬理学雑誌   146 ( 2 )   93 - 97   2015.8

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    DOI: 10.1254/fpj.146.93

  • Organelle Dynamics during Bacterial infection PRIP facilitates the autophagic elimination of Staphylococcus aureus in mouse embryonic fibroblasts

    70 ( 1 )   118   2015.2

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  • Salmonella Typhimuriumの細胞内増殖はPLC-related catalytically inactive proteinによるオートファジー調節により抑制される

    原田佳枝, 兼松隆

    Journal of Oral Biosciences Supplement 2015   2015

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  • Prip欠損MEFsにおけるautophagosomeとlysosomeの融合抑制

    原田 佳枝, 原田 佳奈, 兼松 隆

    日本生化学会大会プログラム・講演要旨集 87回   2P-518   2014.10

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  • オートファジー系を介した黄色ブドウ球菌排除機構におけるPRIPの役割解明

    原田佳奈, 原田佳枝, 兼松隆

    日本病態プロテアーゼ学会学術集会プログラム抄録集 19th   45   2013.9

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  • PRIPの遺伝的欠損は脂質生成障害を誘導する(Genetic deficiency of PRIP induces impaired adipogenesis)

    張 君, 大植 香菜, 原田 佳枝, 北山 友也, 兼松 隆

    日本生化学会大会プログラム・講演要旨集 86回   1P-381   2013.9

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  • PRIPはStaphylococcus aureusを包含するオートファゴソームの成熟を制御する

    原田 佳枝, 兼松 隆

    Journal of Oral Biosciences Supplement 2013   229   2013.9

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  • PRIPはStaphylococcus aureusを内包するオートファゴソームの成熟を制御する

    原田 佳枝, 林 靖也, 池田 英恵, 兼松 隆

    日本生化学会大会プログラム・講演要旨集 85回   3P-243   2012.12

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  • 脂肪分解・熱産生系を制御する新しい分子PRIP

    奥村 俊哉, 原田 佳枝, 鎌田 伸之, 兼松 隆

    Journal of Oral Biosciences Supplement 2012   125   2012.9

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  • 脂肪分解を制御する新しい分子PRIP

    奥村 俊哉, 原田 佳枝, 溝上 顕子, 平田 雅人, 鎌田 伸之, 兼松 隆

    広島大学歯学雑誌   43 ( 2 )   138   2011.12

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  • PRIPは生体のエネルギー調節機構を制御する

    奥村 俊哉, 原田 佳枝, 溝上 顕子, 平田 雅人, 鎌田 伸之, 兼松 隆

    Journal of Oral Biosciences   53(Suppl.)   159   2011.9

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  • PRIPは細胞内に侵入したStaphylococcus aureusの増殖をオートファジーにより抑制する

    原田 佳枝, 兼松 隆, 平田 雅人

    日本生化学会大会プログラム・講演要旨集 84回   4P-0146   2011.9

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  • 新規分子PRIPが仲介するエネルギー代謝調節機構の解明

    奥村 俊哉, 原田 佳枝, 鎌田 伸之, 兼松 隆

    広島大学歯学雑誌   43 ( 1 )   76   2011.6

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  • PRIPは細胞内に侵入したStaphylococcus aureusに対するオートファジーを調節する

    原田 佳枝, 兼松 隆

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 83回・33回   4P-0599   2010.12

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  • Autophagy induced by Staphylococcus aureus infection and bacterial proliferation in PRIP knockout cells

    Kae Harada, Takashi Kanematsu

    JOURNAL OF PHARMACOLOGICAL SCIENCES   112   217P   2010

  • PRIP分子を介したエネルギー代謝調節機構

    原田 佳枝, 田中 寛人, 平田 雅人, 兼松 隆

    Journal of Oral Biosciences   51(Suppl.)   155   2009.8

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  • Journal of Hiroshima University Dental Society

    Journal of Hiroshima University Dental Society   41 ( 1 )   94   2009.6

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  • Staphylococcus aureus infection-induced autophagy in phospholipase C-related inactive protein knockout cells

    Harada K, Okumura T, Kanematsu T

    6th Japan-Korea Conference on Cellular Signaling for Young Scientists   77   2009

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  • 認知症高齢者の全身状態および介護状態と口腔内状態との関係

    井上 俊二, 貞森 紳丞, 濱田 泰三, 香川 和子, 原田 佳枝, 関谷 健祐, 末廣 史雄, 前田 武志, 林 昭志, 佐々木 正和

    日本補綴歯科学会誌   52 ( 2 )   260   2008.4

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  • 認知症高齢者の全身状態と口腔内状態との関係についての経年的観察

    井上 俊二, 貞森 紳丞, 濱田 泰三, 香川 和子, 原田 佳枝, 関谷 健祐, 末廣 史雄, 前田 武志

    広島大学歯学雑誌   39 ( 1 )   76 - 77   2007.6

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  • 認知症高齢者の全身状態と口腔内状態との関係―経年的観察から―

    井上俊二, 貞森紳丞, 濱田泰三, 香川和子, 原田佳枝, 関谷健祐, 末廣史雄, 前田武志, 佐々木正和

    日本補綴歯科学会誌   51 ( 2 )   363   2007.4

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  • 金属アレルギー被疑患者のパッチテスト・元素分析の過去7年間の集計

    内山 裕絵, 二川 浩樹, 牧平 清超, 原田 佳枝, 西村 春樹, 浜田 泰三

    日本補綴歯科学会誌   50 ( 1 )   133   2006.1

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  • Involvement of PRIP-1 in Ins(1,4,5)P3-mediated Ca2+ signaling

    Harada K, Kanematsu T, Hirata M

    75 ( 8 )   985   2003

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  • Roles of PRIP-1, novel Ins(1,4,5)P3 binding protein, in Ca2+ signaling

    Harada K, Hitata M

    2nd Japan-Korea Conference on Cellular Signaliing for Youung Scientists   38   2003

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  • Roles of PRIP-1, novel Ins(1,4,5)P3 binding protein, in Ca2+ signaling

    Harada, K, Kanematsu, T, Hirata

    JOURNAL OF PHARMACOLOGICAL SCIENCES   94-S1   94P   2003

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  • PRIP-1のIns(1,4,5)P3/Ca2+シグナリングにおける役割

    原田 佳枝, 竹内 弘, 照沼 美穂, 兼松 隆, 平田 雅人

    生化学   74 ( 748 )   915   2002.8

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  • Roles of PRIP-1, novel Ins(1,4,5)P3 binding protein, in Ca2+ signaling

    Harada K

    1st Korea-Japan Conference on Signal Transduction   22   2002

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  • イノシトールポリリン酸5-ホスファターゼとプレックストリン相同領域の結合解析

    竹内 弘, 原田 佳枝, 照沼 美穂, 八木澤 仁, 平田 雅人

    生化学   73 ( 8 )   964   2001.8

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Presentations

  • 原田 佳枝, 西 恭宏   顎下腺摘出患者に対し口腔機能訓練を行い口腔機能に改善が認められた症例  

    日本老年歯科医学会 第33回学術大会  2022.6 

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  • Kae Harada   Efforts Towards Developing Denture Care Products for the Super-Aging Society   Invited

    2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • 村上 格, 宮田春香, 中西悠梨香, 原田佳枝, 西 恭宏, 西村正宏   治療用義歯に関する臨床エビデンス 症例報告によるシステマティックレビュー  

    (公社)日本補綴歯科学会第132回学術大会 

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    Event date: 2023.5

    Language:Japanese  

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  • 西 恭宏, 原田佳枝, 中村康典   義歯洗浄剤と超音波洗浄器の併用と洗浄水温度が微生物除去効果に及ぼす影響  

    第20回日本口腔ケア学会総会・学術大会 第3 回国際口腔ケア学会総会・学術大会 合同会議 

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    Event date: 2023.4

    Language:Japanese  

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  • 原田佳枝, 堀之内玲耶, 村上 格, 西 恭宏, 西村正宏   紫外線照射装置の除菌効果と義歯への応用  

    第20回日本口腔ケア学会総会・学術大会 第3 回国際口腔ケア学会総会・学術大会 合同会議 

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    Event date: 2023.4

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  • 原田佳枝, 堀之内玲耶, 山下裕輔, 村上 格, 西 恭宏, 西村正宏   紫外線照射装置のCandida albicans に 対する除菌効果と義歯への応用  

    第15回日本義歯ケア学会学術大会  2023.1 

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    Language:Japanese  

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  • 原田佳枝,堀之内玲耶,山下裕輔,村上 格,西 恭宏,西村正宏   ポータブル紫外線照射装置の義歯への応用とその除菌効果  

    令和4年度公益社団法人日本補綴歯科学会九州支部学術大会  2022.11  公益社団法人 日本補綴歯科学会 九州支部

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    Event date: 2022.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:佐世保市  

  • 村上 格,宮田春香,中西悠梨香,原田佳枝,西 恭宏,西村正宏   我が国における治療用義歯の臨床エビデンスに関するレビュー  

    令和4年度公益社団法人日本補綴歯科学会九州支部学術大会  2022.11  公益社団法人 日本補綴歯科学会 九州支部

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    Event date: 2022.11

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    Venue:佐世保市  

  • Kae Harada   A case of oral function improvement by new denture fabrication and oral function training  

    2022.8 

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  • 村上 格,駒走彩良,小野草太,原田佳枝,西 恭宏,西村正宏   市販口腔保湿剤の選択ならびに管理に関する研究  

    日本補綴歯科学会 第131回学術大会  2022.7  (公社)日本補綴歯科学会

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    Event date: 2022.7

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    Venue:大阪市  

  • 西 恭宏,山下裕輔,村上 格,原田佳枝,益崎与泰,堀之内玲耶,池田菜緒,櫻井智章 ,宮田春香,中村康典,西村正宏   口腔機能低下症の4種下位症状における主検査と代替検査の比較  

    日本老年歯科医学会 第33回学術大会  2022.6  一般社団法人 日本老年歯科医学会

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    Event date: 2022.6

  • 山下裕輔,西 恭宏,村上 格,山下皓三,原田佳枝 ,益崎与泰,池田菜緒,櫻井智章 ,宮田春香,西村正宏   2施設における口腔機能低下症の検査と管理状況の実態調査  

    日本老年歯科医学会 第33回学術大会  2022.6  一般社団法人 日本老年歯科医学会

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    Event date: 2022.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:新潟市  

  • 原田佳枝,堀之内玲耶,村上 格,下田平直大,鎌下祐次,山下裕輔,西 恭宏,西村正宏   義歯安定剤使用者のための新しい泡タイプ義歯洗浄剤の開発  

    第24回日本歯科医学会学術大会  2021.9 

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    Event date: 2021.9

  • 村上 格,元山彩良,原田佳枝,西 恭宏,西村正宏   口腔保湿剤の抗真菌性に関する研究  

    第24回日本歯科医学会学術大会  2021.9 

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    Event date: 2021.9

  • 山下裕輔,西 恭宏,村上 格,原田佳枝,堀之内玲耶,西村正宏   ショットブラストによるレジン床義歯粘膜面の表面性状と微生物付着状況の検討  

    第24回日本歯科医学会学術大会  2021.9 

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    Event date: 2021.9

  • 駒走彩良,村上 格,小野草太,原田佳枝,西 恭宏,西村正宏   市販口腔保湿剤における保管温度と保管期間がpHならびにORPへ及ぼす影響  

    令和3年度日本補綴歯科学会九州支部学術大会  2021.9  公益社団法人 日本補綴歯科学会 九州支部

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    Event date: 2021.9

  • 元山 彩良, 村上 格, 原田 佳枝, 西 恭宏, 西村 正宏   市販口腔保湿剤のpH値に関する研究  

    日本補綴歯科学会第130回記念学術大会  2021.6  (公社)日本補綴歯科学会

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    Event date: 2021.6

    Language:Japanese  

  • 堀之内 玲耶, 原田 佳枝, 西村 正宏   高齢マウス顎骨由来間葉系幹細胞の老化現象と骨分化への影響の解析  

    日本補綴歯科学会第130回記念学術大会  2021.6  (公社)日本補綴歯科学会

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    Event date: 2021.6

    Language:Japanese  

  • 山下 裕輔, 西 恭宏, 北上 真由美, 神之田 理恵, 大迫 奈里子, 村上 格, 末廣 史雄, 益崎 与泰, 原田 佳枝, 堀之内 玲耶, 池田 菜緒, 櫻井 智章, 西村 正宏   有床義歯における片側咬合力計測の有効性の検討  

    日本補綴歯科学会第130回記念学術大会  2021.6  (公社)日本補綴歯科学会

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    Event date: 2021.6

    Language:Japanese  

  • 村上 格,原田佳枝,元山彩良,西 恭宏,西村正宏   温度とpHは口腔保湿剤の抗真菌性に影響を及ぼす  

    第32回日本老年歯科医学会学術大会  2021.6 

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    Event date: 2021.6

  • 西 恭宏, 山下 裕輔, 村上 格, 原田 佳枝, 益崎 与泰, 峰元 洋光, 堀之内 玲耶, 池田 菜緒, 中村 康典, 西村 正宏   患者特性からみた口腔機能低下症、サルコペニア、フレイルの関係  

    第32回日本老年歯科医学会学術大会  2021.6  (一社)日本老年歯科医学会

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    Event date: 2021.6

    Language:Japanese  

  • 原田佳枝,堀之内玲耶,村上 格,西 恭宏,西村正宏   新規開発した義歯洗浄剤を含めた泡タイプ義歯洗浄剤の比較検討  

    第13回日本義歯ケア学会学術大会  日本義歯ケア学会

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    Event date: 2021.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web  

  • 西 恭宏,村上 格,原田佳枝,堀之内玲耶,西村正宏   義歯洗浄剤の使用頻度は義歯のカンジダ付着量に影響する-施設入所者における調査から-  

    第13回日本義歯ケア学会学術大会  日本義歯ケア学会

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    Event date: 2021.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web  

  • 原田佳枝,堀之内玲耶,村上 格,西 恭宏,西村正宏   新規開発した義歯洗浄剤を含めた泡タイプ義歯洗浄剤の比較検討  

    第13回日本義歯ケア学会学術大会  2021.2 

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    Event date: 2021.2

    Language:Japanese  

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  • M. Murakami, K. Harada, Y. Nishi and M. Nishimura   Storage temperature and pH of commercial oral moisturizers affects the antifungal effects   International conference

    7th Biennial Joint Congress of JPS-CPS-KAP  JPS-CPS-KAP

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    Event date: 2021.2

    Language:English   Presentation type:Poster presentation  

  • 西 恭宏、山下 裕輔、村上 格、原田 佳枝、益崎 与泰、峰元 洋光、堀之内 玲耶、池田 菜緒、中村 康典、西村 正宏   補綴外来患者における口腔機能低下症の下位症状と身体的フレイル指標の関連  

    日本老年歯科医学会第31回学術大会  一般社団法人 日本老年歯科医学会

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Web  

  • 堀之内玲耶、原田佳枝、山下裕輔、村上 格、西恭宏、西村正宏   義歯安定剤ユーザーに向けた新規義歯洗浄剤の洗浄効果の検討  

    日本老年歯科医学会 第30回学術大会  一般社団法人 日本老年歯科医学会

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    Event date: 2020.10 - 2020.11

    Language:English   Presentation type:Poster presentation  

    Venue:Web  

  • 村上 格,原田佳枝,元山彩良,西 恭宏,西村正宏   口腔保湿剤の保管温度ならびにpHが抗真菌性に及ぼす影響  

    日本老年歯科医学会 第30回学術大会  一般社団法人 日本老年歯科医学会

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Poster presentation  

  • 原田佳枝,堀之内玲耶,村上 格,西 恭宏,西村正宏   要介護者に向けた義歯安定剤が付着した義歯の新規清掃法の開発  

    第17回日本口腔ケア学会学術大会  一般社団法人日本口腔ケア学会

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎/web併催  

  • 原田佳枝,堀之内玲耶,山下裕輔,下田平直大,村上 格,西 恭宏,西村正宏   義歯安定剤ユーザーに向けた新規義歯洗浄剤の洗浄効果の検討  

    日本補綴歯科学会第129回学術大会  公益社団法人 日本補綴歯科学会

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    Event date: 2020.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Web  

  • 柳澤嵩大,西村正宏,末廣史雄,益崎与泰,原田佳枝   抗菌性ペプチドLL-37のリンパ管新生促進効果の検討  

    日本補綴歯科学会第129回学術大会  公益社団法人 日本補綴歯科学会

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    Event date: 2020.6

    Language:Japanese  

    Venue:Web  

  • 村上 格,西 恭宏,原田佳枝,益崎与泰,峰元洋光,柳澤嵩大,西村正宏   パイナップル由来セラミドの経口摂取は口腔乾燥を改善する:二重盲検無作為化交差試験  

    日本補綴歯科学会第129回学術大会  公益社団法人 日本補綴歯科学会

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    Event date: 2020.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Web  

  • 原田佳枝,堀之内玲耶,神園健人,濱坂厘杏,下田平直大,村上 格, 西 恭宏,西村正宏   義歯安定剤使用者に向けた新しい義歯洗浄法の開発  

    第12回日本義歯ケア学会学術大会  日本義歯ケア学会

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    Event date: 2020.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知学院大学楠元キャンパス  

  • 堀之内玲耶,原田佳枝,村上 格,西 恭宏,西村正宏   適切なHLB値の界面活性剤は義歯安定剤ユーザーに向けた新規義歯洗浄剤に有用である  

    第1回南九州歯学会  南九州歯学会

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    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:鹿児島大学 鶴陵会館  

  • 村上 格,西 恭宏,原田佳枝,西村正宏   医療従事者における口腔保湿剤の認知度ならびに指導実態の調査  

    日本老年歯科医学会 第30回学術大会  一般社団法人 日本老年歯科医学会

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    Event date: 2019.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台国際センター  

  • 山下裕輔,西 恭宏,村上 格,山下皓三,原田佳枝,益崎与泰,有馬 敬,鎌下祐次,中村康典,西村正宏   2施設における口腔機能低下症の検査と診断状況  

    日本老年歯科医学会 第30回学術大会  一般社団法人 日本老年歯科医学会

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    Event date: 2019.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台国際センター  

  • 原田佳枝,村上 格,西 恭宏,西村正宏   適正なHLB値の界面活性剤は義歯安定剤ユーザーに向けた新しい義歯洗浄法に有用である  

    日本老年歯科医学会 第30回学術大会  一般社団法人 日本老年歯科医学会

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    Event date: 2019.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台国際センター  

  • 堀之内玲耶,原田佳枝,村上 格,西 恭宏,西村正宏   適正範囲のHLB値をもつ界面活性剤はクリームタイプ義歯安定剤除去にて有用である  

    第128回日本補綴歯科学会学術大会  公益社団法人 日本補綴歯科学会

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    Event date: 2019.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:札幌コンベンションセンター  

  • 堀之内 玲耶,原田 佳枝,西村 正宏   界面活性剤のHLB値はクリームタイプ義歯安定剤除去に影響する  

    第9回補綴若手研究会  公益社団法人 日本補綴歯科学会九州支部

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    Event date: 2019.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:鹿児島  

  • 原田 佳枝   市民フォーラム 義歯と健康  

    平成30年度日本補綴歯科学会九州支部会学術大会 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:熊本県歯科医師会館  

  • 新屋 俊明, 西 恭宏, 中村 康典, 村上 格, 原田 佳枝, 鎌下 祐次, 西村 正宏   舌苔付着の主観評価と舌背細菌数の関係  

    日本老年歯科医学会 第29回学術大会  2018.9  (一社)日本老年歯科医学会

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    Event date: 2018.6

  • 村上 格,藤島 慶,原田佳枝,西 恭宏,西村正宏   口腔保湿剤の保管温度と種類がその抗真菌性に及ぼす影響  

    日本補綴歯科学会 第127回学術大会  公益社団法人 日本補綴歯科学会

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    Event date: 2018.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:岡山コンベンションセンター  

  • 原田 佳枝,三村 純代,洪 光,二川 浩樹,西村 正宏   義歯安定剤ユーザーに適した新しい義歯洗浄法開発の試み  

    第10回日本義歯ケア学会学術大会  日本義歯ケア学会

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    Event date: 2018.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島大学蔵本キャンパス  

  • 原田佳枝,三村純代,洪 光,安部倉 仁,二川浩樹,西村正宏   義歯安定剤使用者のための新しい義歯洗浄剤の開発  

    第126回日本補綴歯科学会学術大会  日本補綴歯科学会

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    Event date: 2017.6 - 2017.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川県横浜市、パシフィコ横浜  

  • 末廣 史雄, 藤島 慶, 益崎 与泰, 原田 佳枝, 柳澤 嵩大, 西村 正宏   顎骨再生を目的とした顎骨骨髄間質細胞培養法の開発  

    第126回日本補綴歯科学会学術大会  2017.7  (公社)日本補綴歯科学会

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    Event date: 2017.6 - 2017.7

  • 下田平 直大, 末廣 史雄, 藤島 慶, 原田 佳枝, 益崎 与泰, 西 恭宏, 西村 正宏   口腔インプラント専門外来におけるインプラントオーバーデンチャーの経過報告について  

    第34回日本口腔インプラント学会九州支部学術大会  2017.1  (公社)日本口腔インプラント学会

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    Event date: 2017.1

  • 原田佳枝,三村純代,洪 光,橋田竜閲,安部倉仁,村田比呂司,二川浩樹,西村正宏   アクリルレジン床に付着した義歯安定剤除去におけるセルラーゼの有用性  

    平成28年度 公益社団法人日本補綴歯科学会九州支部・中国四国支部合同学術大会  公益社団法人日本補綴歯科学会九州支部・中国四国支部

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:熊本県熊本市、熊本県歯科医師会館  

  • 末廣史雄、益﨑与泰、原田佳枝、柳澤嵩大、西村正宏   顎骨増生を目的とした低侵襲・効率的な顎骨骨髄間質細胞培養  

    平成28年度 公益社団法人日本補綴歯科学会九州・中四国支部学術大会  公益社団法人日本補綴歯科学会九州・中四国支部

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    Event date: 2016.9

    Language:English   Presentation type:Poster presentation  

    Venue:熊本県熊本市、熊本県歯科医師会館  

  • 原田佳枝、兼松隆   PRIPはnon-professional phagocytesにおいてオートファジーによる感染細菌排除機構を抑制する  

    BMB2015  日本分子生物学会、日本生化学会

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    Event date: 2015.12

    Language:English   Presentation type:Poster presentation  

    Venue:兵庫県神戸市、神戸ポートピアアイランド  

  • Intracellular growth of Salmonella Typhimurium is inhibited by autophagic regulation of PLC-related catalytically inactive protein   Intracellular growth of Salmonella Typhimurium is inhibited by autophagic regulation of PLC-related catalytically inactive protein  

    第57回歯科基礎医学会学術大会  歯科基礎医学会

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:新潟県新潟市、朱鷺メッセ  

  • Kae Harada-Hada,Takashi Kanematsu   Salmonella Typhimurium enclosed in p62/LC3-positive vacuoles is increased in Prip-knockout cells   International conference

    第48回広島大学歯学会総会  広島大学歯学会

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    Event date: 2015.6

    Language:English   Presentation type:Poster presentation  

    Venue:広島大学  

  • 原田佳枝, 稲用友佳, 荻野洋一郎   口腔機能と認知症の介入研究に関する システマティックレビューの進捗状況   Invited

    認知症と口腔機能研究会 第4回学集大会  2023.8 

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    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 村上 格, 駒走彩良, 小野草太, 原田佳枝, 西 恭宏, 西村正宏   市販口腔保湿剤の選択ならびに管理に関する研究  

    日本補綴歯科学会 第131回学術大会  2022.7 

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Intellectual Property

  • Denture Cleaner

    HARADA Kae

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    Application no:特願2019-087801  Date applied:2019.5

    Announcement no:特開2019-196350  Date announced:2019.11

    Patent/Registration no:特許第6861420号  Date registered:2021.4 

    J-GLOBAL

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  • 義歯安定剤除去剤及び除去方法

    原田 佳枝, 三村 純代, 二川 浩樹

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    Applicant:国立大学法人広島大学

    Application no:特願2016-012907  Date applied:2016.1

    Announcement no:特開2017-132707  Date announced:2017.8

    J-GLOBAL

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Works

Awards

  • 令和5年度日本義歯ケア学会優秀論文賞

    2024.2   日本義歯ケア学会  

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  • 令和4年度鹿児島大学歯学部同窓会奨励賞

    2022.11   鹿児島大学歯学部同窓会   An in vitro study on the selection of surfactants for removal of cream denture adhesives from dentures and their application to denture cleaners

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  • Best Oral Presentation Award at the 12th annual meeting of the Japan Denture Care Society

    2021.2   The Japan Denture Care Society  

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Research Projects

  • 高齢ドナー顎骨由来MSCを用いたSASP抑制による高度顎堤吸収治療法の開発研究

    Grant number:21K10006  2021.4 - 2024.3

    日本学術振興会  科学研究費補助金  基盤研究(C)

    原田 佳枝

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    Authorship:Principal investigator 

  • Investigation of the Effect of Light Irradiation Sterilization on Microorganisms on Dentures

    2021.4

    Collaborative research 

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    Authorship:Coinvestigator(s)  Grant type:Collaborative (industry/university)

    Grant amount:\1300000 ( Direct Cost: \1000000 、 Indirect Cost:\300000 )

  • Developmental research of a severe bone resorption therapy by using MSCs via autophagic modulation

    Grant number:18K09703  2018.4 - 2020.3

    Japan Society for the Promotion of Science(JSPS)  Grants-in-Aid for Scientific Research (KAKENHI)  Grant-in-Aid for Scientific Research(C)

    Kae Harada

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    We prepared MSCs from the jawbones of aged (78-80 weeks) and young (10 weeks) male mice and compared the cells derived from aged mice (OMSC) with those from young mice (YMSCs). The jaw OMSCs had morphological characteristics of senescence, and the senescence marker genes were increased at the mRMA level. On the other hand, autophagy marker genes LC3, Beclin1, and Atg7 of the jaw OMSCs was increased at the mRNA level compared to those of YMSCs, suggesting that autophagy of jaw OMSCs is accelerated at the basal level.

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  • Developmental research of denture cleansers

    2018.1 - 2020.6

    Private Enterprise  Collaboration  Collaboration

    Kae Harada

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    Authorship:Coinvestigator(s) 

  • Elucidation of the molecular basis of Staphylococcus aureus exclusion via autophagy

    Grant number:15K11039  2015.4 - 2018.3

    Japan Society for the Promotion of Science(JSPS)  Grants-in-Aid for Scientific Research (KAKENHI)  Grant-in-Aid for Scientific Research(C)

    Kae Harada

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    Authorship:Principal investigator 

  • PRIP mediates autophagic elimination of intracellular bacteria

    Grant number:25861757  2013.4 - 2015.3

    Japan Society for the Promotion of Science(JSPS)  Grants-in-Aid for Scientific Research (KAKENHI)  Grant-in-Aid for Young Scientists(B)

    Kae Harada

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    Grant type:Competitive

  • A research and development of novel low-cytotoxic oral self-care methods for the patients who use denture adhesives

    Grant number:21791898  2009.4 - 2011.3

    Japan Society for the Promotion of Science(JSPS)  Grants-in-Aid for Scientific Research (KAKENHI)  Grant-in-Aid for Young Scientists(B)

    Kae Harada

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    Authorship:Principal investigator  Grant type:Competitive

  • Developmental research of oral care methods for older denture adhesive users requiring nursing care

    Grant number:22K10082  2022.4 - 2025.3

    Japan Society for the Promotion of Science(JSPS)  Grants-in-Aid for Scientific Research (KAKENHI)  Grant-in-Aid for Scientific Research (C)

    Yuji Kamashita

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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  • ジェルコート保湿による新規保湿法の開発と多軸的評価

    Grant number:21K10257  2021.4 - 2024.3

    日本学術振興会  科学研究費補助金  基盤研究(C)

    清水 孝治, 西村 正宏, 西 恭宏, 元山 彩良, 原田 佳枝, 村上 格

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    Authorship:Coinvestigator(s) 

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

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  • 義歯上の付着微生物に対する光照射殺菌による影響の検討

    2021.4

    共同研究

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  • 高齢ドナー由来間葉系幹細胞を用いた骨増生時における細菌由来因子影響の解析研究

    Grant number:21K10006  2019.4 - 2022.3

    日本学術振興会  科学研究費補助金  基盤研究(C)

    下田平 直大

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    Grant type:Competitive

  • 高齢ドナー由来間葉系幹細胞を用いた骨増生時における細菌由来因子影響の解析研究

    Grant number:19K10251  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • 食味嗜好に対応する温度調節型保湿法の開発とその有効性に関する多軸的評価

    Grant number:21K09982  2018.4 - 2021.3

    日本学術振興会  科学研究費補助金  基盤研究(C)

    村上 格

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • Development and Multiaxial Evaluation of a Temperature-Controlled moisturizing Method.

    Grant number:18K09665  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Murakami Mamoru

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    The purpose of this study was to evaluate the effectiveness of a temperature-controlled moisturizing method. The results of sensory test showed that the significant difference between men and women in the VAS score was reduced when the moisturizer was heated to 37°C. Examination of the heating and cooling conditions of the moisturizers showed that the antifungal activity of the moisturizers was related to the type of moisturizer and storage temperature, with the highest antifungal activity when the moisturizers were stored at 37°C.

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  • Studies on molecular mechanisms in differentiation and dedifferentiation of adipocytes

    Grant number:26670809  2014.4 - 2016.3

    Japan Society for the Promotion of Science(JSPS)  Grants-in-Aid for Scientific Research (KAKENHI)  Grant-in-Aid for Challenging Exploratory Research

    Takashi Kanematsu

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  • GABAシグナリング調節分子による摂食調節メカニズムの解明研究

    Grant number:21390495  2009.4 - 2011.3

    日本学術振興会  科学研究費  基盤研究(B)

    兼松 隆

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    Authorship:Coinvestigator(s) 

  • GABA(A)受容体輸送調節分子による神経因性疼痛制御の基礎的研究

    Grant number:21659429  2009.4 - 2011.3

    日本学術振興会  科学研究費  挑戦的萌芽研究

    兼松 隆

  • Studies on mechanisms of cell signaling

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    Grant type:Competitive

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Teaching Experience

  • Global Health Care Providers IV

    2019.4
    -
    2020.3
    Institution:Kagoshima University

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    Level:Undergraduate (specialized)  Country:Japan

  • Research Practice II

    2018.12
    Institution:Kagoshima University

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    Level:Undergraduate (specialized)  Country:Japan

  • Research Practice I

    2018.4
    Institution:Kagoshima University

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    Level:Undergraduate (specialized)  Country:Japan

  • Clinical Practice II

    2017.3
    Institution:Kagoshima University

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    Level:Undergraduate (specialized)  Country:Japan

  • Clinical Practice I

    2016.10
    Institution:Kagoshima University

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    Level:Undergraduate (specialized)  Country:Japan

  • 臨床予備実習

    2016.4
    Institution:鹿児島大学

  • Removable Prosthodntics

    2016.4
    Institution:Kagoshima University

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    Level:Undergraduate (specialized)  Country:Japan

  • 歯科用薬物

    2009.4
    -
    2016.3
    Institution:広島大学

  • 細胞分子薬理学実習

    2009.4
    -
    2016.3
    Institution:広島大学

  • 細胞分子薬理学演習

    2009.4
    -
    2016.3
    Institution:広島大学

  • 薬理学・歯科薬理学

    2009.4
    -
    2016.3
    Institution:広島大学

  • 基礎オーラルサイエンス実習

    2009.4
    -
    2016.3
    Institution:広島大学

  • 口腔機能学基礎実習

    2009.4
    -
    2016.3
    Institution:広島大学

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