Updated on 2021/06/15

写真a

 
YAMASHITA Akira
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Functional Biology and Pharmacology Assistant Professor
Title
Assistant Professor

Degree

  • 博士(薬学) ( 2014.3   星薬科大学 )

Research Interests

  • オレキシン 青斑核 ノルアドレナリン 自律神経 疼痛 睡眠障害 光遺伝学 カルシウムイメージング in vivo

Research Areas

  • Life Science / Neuroscience-general

Education

  • Hoshi University

    - 2014.3

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    Country: Japan

Research History

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Functional Biology and Pharmacology   Assistant Professor

    2015.10

  • Nagoya University   Researcher

    2014.4 - 2015.9

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    Country:Japan

Qualification acquired

  • Pharmacist

 

Papers

  • Moriya S, Yamashita A, Masukawa D, Seroyama H, Hwang Y, Yamanaka A, Kuwaki T .  Involvement of A13 dopaminergic neurons located in the zona incerta in nociceptive processing: a fiber photometry study. .  Molecular brain   2020Involvement of A13 dopaminergic neurons located in the zona incerta in nociceptive processing: a fiber photometry study.Reviewed

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  • Moriya S, Yamashita A, Masukawa D, Kambe Y, Sakaguchi J, Setoyama H, Yamanaka A, Kuwaki T .  Involvement of supralemniscal nucleus(B9) 5-HT neuronal system in nociceptive processing: a fiber photometry study. .  Molecular brain   2020Involvement of supralemniscal nucleus(B9) 5-HT neuronal system in nociceptive processing: a fiber photometry study.Reviewed

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  • Moriya S, Yamashita A, Nishi R, Ikoma Y, Yamanaka A, Kuwaki T .  Acute nociceptive stimuli rapidly induce the activity of serotonin and noradrenalin neurons in the brain stem of awake mice. .  IBRO Rep   2019Acute nociceptive stimuli rapidly induce the activity of serotonin and noradrenalin neurons in the brain stem of awake mice.Reviewed

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  • 7. Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H, Yamanaka A, Tawfik VL, Kuzumaki N, Navratilova E, Porreca F, Narita M .  Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. .  Molecular pain   2018Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.Reviewed

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  • Moriya S, Yamashita A, Kawashima S, Nishi R, Yamanaka A, Kuwaki T. .  Acute Aversive Stimuli Rapidly Increase the Activity of Ventral Tegmental Area Dopamine Neurons in Awake Mice. .  Neuroscience   2018Acute Aversive Stimuli Rapidly Increase the Activity of Ventral Tegmental Area Dopamine Neurons in Awake Mice.Reviewed

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  • 6. Futatsuki T, Yamashita A, Ikbar KN, Yamanaka A, Arita K, Kakihana Y, Kuwaki .  Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia. .  Scientific reports   2018Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia.Reviewed

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  • Hamada Y, Yamashita A, Tamura H, Narita M, Kuzumaki N, Narita M .  Functional role of cortical astrocytes in sleep/affective dysregulation under the chronic pain: analysis by artificial control of astrocytes using optogenetics. .  Nihon yakurigaku zasshi. Folia pharmacologica Japonica148 ( 3 ) 128 - 133   2016.9Functional role of cortical astrocytes in sleep/affective dysregulation under the chronic pain: analysis by artificial control of astrocytes using optogenetics.Reviewed

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  • Hori N, Narita M, Yamashita A, Horiuchi H, Hamada Y, Kondo T, Watanabe M, Igarashi K, Kawata M, Shibasaki M, Yamazaki M, Kuzumaki N, Inada E, Ochiya T, Iseki M, Mori T, Narita M .  Changes in the expression of IL-6-Mediated MicroRNAs in the dorsal root ganglion under neuropathic pain in mice. .  Synapse (New York, N.Y.)70 ( 8 ) 317 - 324   2016.8Changes in the expression of IL-6-Mediated MicroRNAs in the dorsal root ganglion under neuropathic pain in mice.Reviewed

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  • Inutsuka A, Yamashita A, Chowdhury S, Nakai J, Ohkura M, Taguchi T, Yamanaka A .  The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation. .  Scientific Reports6   29480   2016.7The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation.Reviewed

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  • Sakai H, Sato K, Kai Y, Shoji T, Hasegawa S, Nishizaki M, Sagara A, Yamashita A, Narita M .  Distribution of aquaporin genes and selection of individual reference genes for quantitative real-time RT-PCR analysis in multiple tissues of the mouse. .  Canadian journal of physiology and pharmacology92   789 - 796   2014.9Distribution of aquaporin genes and selection of individual reference genes for quantitative real-time RT-PCR analysis in multiple tissues of the mouse.Reviewed

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  • Yamashita A, Hamada A, Suhara Y, Kawabe R, Yanase M, Kuzumaki N, Narita M, Matsui R, Okano H, Narita M .  Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain. .  Synapse (New York, N.Y.)68   235 - 247   2014.6Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain.Reviewed

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  • Narita M, Ikegami D, Yamashita A, Ushijima T .  [Global understanding of pain]. .  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology32   63 - 72   2014.4[Global understanding of pain].Reviewed

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  • Odo M, Koh K, Takada T, Yamashita A, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M .  Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state. .  Synapse (New York, N.Y.)68   153 - 158   2014.4Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state.Reviewed

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  • Ito H, Yanase M, Yamashita A, Kitabatake C, Hamada A, Suhara Y, Narita M, Ikegami D, Sakai H, Yamazaki M, Narita M .  Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons. .  Molecular brain6   59   2013.12Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons.Reviewed

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  • Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M .  к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. .  Scientific reports3   3213   2013.11к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling.Reviewed

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  • Ikegami D, Yamashita A, Narita M .  [Understanding of the psychiatry in palliative care: dysfunction of the rewarding system under the pain state associated with exacerbating pain]. .  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology33   199 - 204   2013.11[Understanding of the psychiatry in palliative care: dysfunction of the rewarding system under the pain state associated with exacerbating pain].Reviewed

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  • Takada T, Yamashita A, Date A, Yanase M, Suhara Y, Hamada A, Sakai H, Ikegami D, Iseki M, Inada E, Narita M .  Changes in the circadian rhythm of mRNA expression for ?-opioid receptors in the periaqueductal gray under a neuropathic pain-like state. .  Synapse (New York, N.Y.)67   216 - 223   2013.5Changes in the circadian rhythm of mRNA expression for ?-opioid receptors in the periaqueductal gray under a neuropathic pain-like state.Reviewed

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  • Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, Furuya M, Kobayashi Y, Miyashita K, Okutsu D, Kato A, Nakamura A, Araki A, Omi K, Nakamura M, James Okano H, Okano H, Ando T, Takeshima H, Ushijima T, Kuzumaki N, Suzuki T, Narita M .  Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. .  Brain : a journal of neurology136   828 - 843   2013.3Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain.Reviewed

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  • Torigoe K, Nakahara K, Rahmadi M, Yoshizawa K, Horiuchi H, Hirayama S, Imai S, Kuzumaki N, Itoh T, Yamashita A, Shakunaga K, Yamasaki M, Nagase H, Matoba M, Suzuki T, Narita M .  Usefulness of olanzapine as an adjunct to opioid treatment and for the treatment of neuropathic pain. .  Anesthesiology116   159 - 169   2012.7Usefulness of olanzapine as an adjunct to opioid treatment and for the treatment of neuropathic pain.Reviewed

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  • Enomoto T, Yamashita A, Torigoe K, Horiuchi H, Hirayama S, Nakahara K, Yanase M, Sakai H, Ikegami D, Nagase H, Suzuki T, Iseki M, Inada E, Narita M .  Effects of mirtazapine on sleep disturbance under neuropathic pain-like state. .  Synapse (New York, N.Y.)66   483 - 488   2012.6Effects of mirtazapine on sleep disturbance under neuropathic pain-like state.Reviewed

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  • Takemura Y, Yamashita A, Horiuchi H, Furuya M, Yanase M, Niikura K, Imai S, Hatakeyama N, Kinoshita H, Tsukiyama Y, Senba E, Matoba M, Kuzumaki N, Yamazaki M, Suzuki T, Narita M .  Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis. .  Synapse (New York, N.Y.)65   668 - 676   2011.7Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis.Reviewed

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  • Narita M, Niikura K, Nanjo-Niikura K, Narita M, Furuya M, Yamashita A, Saeki M, Matsushima Y, Imai S, Shimizu T, Asato M, Kuzumaki N, Okutsu D, Miyoshi K, Suzuki M, Tsukiyama Y, Konno M, Yomiya K, Matoba M, Suzuki T .  Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex. .  Pain152   1358 - 1372   2011.6Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex.Reviewed

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  • Rahmadi M, Narita M, Yamashita A, Imai S, Kuzumaki N, Suzuki T .  Sleep disturbance associated with an enhanced orexinergic system induced by chronic treatment with paroxetine and milnacipran. .  Synapse (New York, N.Y.)65   652 - 657   2011.6Sleep disturbance associated with an enhanced orexinergic system induced by chronic treatment with paroxetine and milnacipran.Reviewed

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Awards

  • 第67回 西日本生理学会 日本生理学会九州奨励賞

    2016.10   西日本生理学会   ファイバーフォトメトリー法を用いた急性ストレス負荷による循環応答時におけるオレキシン神経活動の測定

    山下 哲

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 第15回九州脳・高血圧・循環制御研究会 最優秀発表賞

    2016.7   九州脳・高血圧・循環制御研究会   ストレス負荷による循環応答時におけるオレキシン神経活動の自由行動マウスからの計測

    山下 哲

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 宮田心臓病研究振興基金 未成年心臓血管病の学究等に対する奨励賞

    2016.3   宮田心臓病研究振興基金   光遺伝学を用いた心筋の遠隔操作による無線ペーシング技術の開発

    山下 哲

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

  • 新学術領域「共感性の進化・神経基盤」第2回領域会議  若手優秀発表賞

    2015.1   新学術領域「共感性の進化・神経基盤」   神経障害性疼痛に伴う睡眠障害発症時における前帯状回アストロサイトの関与

    山下 哲

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  • 星薬科大学大谷記念研究助成金 大谷賞

    2013.5   星薬科大学   神経障害性疼痛に伴う睡眠障害発現における脳神経ネットワーク異常の解析

    山下 哲

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    Country:Japan

Research Projects

  • 自律応答神経回路に着目したうつ病発症脳内メカニズムの解明

    2020.4 - 2024.3

    科学研究費補助金  基盤研究(C)

  • 心房細動患者に対する光遺伝学を用いた新規治療法の開発

    2019.12 - 2020.11

    民間財団等  先進医薬研究振興財団 循環医学分野 若手研究助成 

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    Grant type:Competitive

  • リード線なし心臓ペーシングシステムに基づく新規不整脈治療法の開発

    2019.11 - 2021.3

    民間財団等  横山臨床薬理研究助成基金 萌芽的研究助成金 

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    Grant type:Competitive

  • 睡眠中の記憶形成と消去に関わる神経機構の解明

    2018.10 - 2023.3

    科学研究費補助金  国際共同研究強化(B)

  • 情動ストレス負荷に対する自律神経応答の脳神経回路メカニズム解明

    2017.4 - 2019.3

    科学研究費補助金  若手研究(B)

  • 光遺伝学を用いた心筋の遠隔光操作による無線ペーシング技術の開発

    2015.12 - 2016.12

    民間財団等  宮田心臓病研究振興基金医学研究の学究等に対する奨励金 

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    Grant type:Competitive

  • 意識下活動動物からの特定神経活動記録法によるオレキシン神経の生理機能解明

    2015.11 - 2016.11

    民間財団等  児玉記念基礎医学研究助成基金: 新規研究助成 

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    Grant type:Competitive

  • 青斑核ノルアドレナリン神経機能の全解明

    2015.4 - 2017.3

    科学研究費補助金  若手研究(B)

  • 意識下に自由行動するマウスを用いた青斑核ノルアドレナリン神経機能の解明

    2014.8 - 2015.3

    科学研究費補助金  研究活動スタート支援

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Teaching Experience

  • 生理学

    2016.4
    Institution:鹿児島大学

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    Level:Undergraduate (specialized)  Country:Japan

  • 脳科学

    2016.4
    Institution:鹿児島大学

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    Level:Postgraduate  Country:Japan