Faculty Profiles - Yuichi Goto

Papers - Yuichi Goto

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Yoshinori Uchino , Yuichi Goto , Yusuke Konishi , Kan Tanabe , Hiroko Toda , Masumi Wada , Yoshiaki Kita , Mahiro Beppu , Shinichiro Mori , Hiroshi Hijioka , Takao Otsuka , Shoji Natsugoe , Eiji Hara , Tsuyoshi Sugiura . Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common-A Metagenomic Comparison with Healthy Subjects . Cancers13 ( 13 ) 3332 2021.7Reviewed

Hashiguchi Y, Kawano S, Goto Y, Yasuda K, Kaneko N, Sakamoto T, Matsubara R, Jinno T, Maruse Y, Tanaka H, Morioka M, Hattori T, Tanaka S, Kiyoshima T, Nakamura S. . Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2. . J Cell Physiol. 2017.11Reviewed

Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mituhiro Hirano, Teppei Jinno, Yasuyuki Maruse, Takeshi Toyoshima, Ryoji Kitamura, Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura . Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype. . Clin Exp Metastasis.31 ( 3 ) 293 - 306 2014.3Reviewed

Kosuke Fukuda, Yuto Hozaka, Hideyuki Oi, Miyo Tomita, Tetsuya Idichi, Yoichi Yamasaki, Yota Kawasaki, Yodai Hayashi, Yuichi Goto, Tsuyoshi Sugiura, Toshiaki Akahane, Michiyo Higashi, Akihide Tanimoto, Takao Ohtsuka . Association between intra-tumoral microbiome and genetic alterations in intraductal papillary mucinous neoplasms of the pancreas . Pancreatology25 905 - 911 2025.9Reviewed

Shiho Yokomizo, Naoki Kaneko, Hu Chen, Lijing Yan, Shoji Tsuji, Shohei Akagawa, Junsei Sameshima, Tomoki Sueyoshi, Haruki Nagano, Yuka Miyahara, Yasuhisa Kamikaseda, Hajime Kido, Yoshikazu Hayashi, Masaki Yamauchi, Tamotsu Kiyoshima, Yuichi Goto, Yukiko Ohyama, Kazunari Kaneko, Masafumi Moriyama, Shintaro Kawano . Dysbiosis of the gut microbiome may contribute to the pathogenesis of oral lichen planus through Treg dysregulation . Mucosal Immunol25 1933 - 0219 2025.6Reviewed International coauthorship

Yuichi Goto • Hiroshi Hijioka • Yoshinori Uchino • Tsuyoshi Sugiura • Tatsuo Okui . Numb Chin Syndrome as the Initial Presentation of Mandibular Metastasis of Colorectal Cancer: A Case Report . Cureus16 ( 3 ) e56133 2024.3Reviewed

Hiroe Kakehashi, Mizuki Sakamoto, Masafumi Moriyama, Yuichi Goto, Ryoji Kitamura, Kenichi Ogata, Seiji Nakamura, Shintaro Kawano . The clinical effectiveness of conservative surgical management in medication-related osteonecrosis of the Jaw . Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology4 2023.11Reviewed

Yuto Hozaka, Hideyuki Oi, Souichi Satake, Yoshinori Uchino, Yuichi Goto, Tetsuya Idichi, Kiyonori Tanoue, Yoichi Yamasaki, Yota Kawasaki, Yuko Mataki, Hiroshi Kurahara, Akihiro Nakajo, Michiyo Higashi, Akihide Tanimoto, Tsuyoshi Sugiura, Takao Ohtsuka . Are intratumoral microbiota involved in the progression of intraductal papillary mucinous neoplasms of the pancreas? . Surgery 2022.11Reviewed

Yuichi Goto・Haruyuki Imamura・Ryoichi Sakamoto・Yoshinori Uchino・Hiroshi Hijioka・Tsuyoshi Sugiura . Conservative treatment of unilateral chylothorax developed after radical neck dissection: A case report . 34 ( 3 ) 2022.9Reviewed

Kazuki Mori, Tomofumi Hamada, Mahiro Beppu, Hiroki Tsuchihashi, Yuichi Goto, Kenichi Kume, Hiroshi Hijioka, Keitaro Nishi, Yumiko Mishima, Tsuyoshi Sugiura . Detecting Early-Stage Oral Cancer from Clinically Diagnosed Oral Potentially Malignant Disorders by DNA Methylation Profile . Cancers14 ( 11 ) 2646 2022.5Reviewed

Keitaro Nishi, Hiroaki Kanouchi, Akihiko Tanaka, Maya Nakamura, Tomofumi Hamada, Yumiko Mishima, Yuichi Goto, Kenichi Kume, Mahiro Beppu, Hiroshi Hijioka, Hiroaki Tabata, Kazuki Mori, Yoshinori Uchino, Kouta Yamashiro, Yoshiaki Matsumura, Yutaro Higashi, Hyuma Makizako, Takuro Kubozono, Toshihiro Takenaka, Mitsuru Ohishi, Tsuyoshi Sugiura . Relationship between Oral Hypofunction, and Protein Intake: A Cross-Sectional Study in Local Community-Dwelling Adults . neutrients13 ( 12 ) 4377 2021.12Reviewed

Nakamura M, Hamada T, Tanaka A, Nishi K, Kume K, Goto Y, Beppu M, Hijioka H, Higashi Y, Tabata H, Mori K, Mishima Y, Uchino Y, Yamashiro K, Matsumura Y, Makizako H, Kubozono T, Tabira T, Takenaka T, Ohishi M, Sugiura T. . Association of Oral Hypofunction with Frailty, Sarcopenia, and Mild Cognitive Impairment: A Cross-Sectional Study of Community-Dwelling Japanese Older Adults . Journal of clinical medicine10 ( 8 ) 1626 2021.4Reviewed

新田哲也, 坂元亮一, 平原成浩, 松村吉晃, 中村康大, 後藤雄一 . ビスフォスフォネート製剤の不適切な服用方法による発症が疑われた口腔粘膜潰瘍 . 日本口腔外科学会雑誌65 ( 9 ) 599 - 604 2019.9Reviewed

Language：Japanese Publishing type：Research paper (scientific journal)

The side effects of peroral bisphosphonate may cause mucous membrane disorders and oral exulceration if individuals dissolve the drug inside the oral cavity on oral administration. We experienced two cases in which we strongly suspected mucous ulcurs due to this drug. Finally, the oral exulceration disappeared after providing instructions on correct administration.
　An 83-year-old woman was referred because of exulceration of the right mandible. She suffered from osteoporosis, thoracic vertebra compression fracture, and dementia, while taking alendronate weekly. The exulceration appeared from the right lower lip to the right mandibular molar gingiva when we absorbed pooled saliva in the right oral cavity when the patient was lying down. We instructed the patient to confirm that the tablet was completely swallowed. The ulcers in the oral cavity completely disappeared 17 days after presentation.
　A 74-year-old woman with osteoporosis presented because of bleeding and pain in the gingiva of the right mandible. She was taking monthly minodronate while wearing incompatible dentures. Exulceration occurred with peripheral redness ranging from the right buccal mucosa to the right molar gingiva of the mandible and the tongue/floor of her mouth, along with a ventrolateral tongue. We taught her how to swallow minodoronate correctly without dentures, and the ulcers healed 4 weeks later.

DOI： https://doi.org/10.5794/jjoms.65.599

Maruse Y, Kawano S, Jinno T, Matsubara R, Goto Y, Kaneko N, Sakamoto T, Hashiguchi Y, Moriyama M, Toyoshima T, Kitamura R, Tanaka H, Oobu K, Kiyoshima T, Nakamura S. . Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma. . Int J Oral Maxillofac Surg.47 ( 7 ) 836 - 845 2018.7Reviewed

Kaneko N, Kawano S, Yasuda K, Hashiguchi Y, Sakamoto T, Matsubara R, Goto Y, Jinno T, Maruse Y, Morioka M, Hattori T, Tanaka S, Tanaka H, Kiyoshima T, Nakamura S. . Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma. . Oral Oncol.75 148 - 157 2017.12Reviewed

Kitamura R, Toyoshima T, Tanaka H, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Oobu K, Nakamura S. . Cytokeratin 17 mRNA as a prognostic marker of oral squamous cell carcinoma. . Oncol Lett.14 ( 6 ) 6735 - 6743 2017.12Reviewed

Sakamoto T, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Kaneko N, Hashiguchi Y, Hattori T, Tanaka S, Kitamura R, Kiyoshima T, Nakamura S. . Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition. . Oral Oncol.69 15 - 25 2017.6Reviewed

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: We previously showed that ΔNp63β, a splicing variant of ΔNp63, mediated EMT and affected cell motility. DNA microarray was thus performed to elucidate the mechanism that ΔNp63β affects cell motility. As the results, Wnt5a was significantly down-regulated by ΔNp63β overexpression in tongue SCC cell line (SQUU-B) with EMT phenotype.
MATERIALS AND METHODS:
Seven OSCC cell lines were used. Expression of ΔNp63, Wnt5a, its receptor Ror2, and matrix metalloproteinases (MMPs) were analyzed by RT-PCR, real-time PCR, and western blotting, and gelatin zymography. Furthermore, we examined the effects of siRNA for Wnt5a or Ror2 and recombinant human Wnt5a (rhWnt5a) on motility of tongue SCC cells. Biopsy specimens from tongue SCC patients were used for immunohistochemical staining of Wnt5a and Ror2.
RESULTS:
Wnt5a and Ror2 were expressed only in SQUU-B cells without ΔNp63 expression, and negatively associated with ΔNp63 expression in other cells. ΔNp63β overexpression in SQUU-B cells decreased Wnt5a and Ror2 expression. By Wnt5a or Ror2 knockdown, cell motility was remarkably inhibited, but EMT markers expression was unaffected. MMP-2 expression and the activities inversely correlated with ΔNp63 expression, and were inhibited by Wnt5a or Ror2 knockdown. Cell motility and MMP-2 activities were recovered by adding rhWnt5a in the cells with Wnt5a knockdown, but not in those with Ror2 knockdown. Moreover, immunohistochemical analyses in tongue SCC specimens found that high expression of Wnt5a or Ror2 was associated with poorer prognosis.
CONCLUSION:
Wnt5a-Ror2 signaling enhanced tongue SCC cell aggressiveness and promoted production of MMP-2 following ΔNp63β-mediated EMT.

DOI： 10.1016/j.oraloncology.2017.03.019.

見立英史, 川野真太郎, 清島保, 三上友里恵, 後藤雄一, 河津俊幸, 池邉哲郎, 中村誠司 . 巨舌を呈した舌対称性脂肪腫症の1例 . 日本口腔腫瘍学会誌28 ( 4 ) 293 - 298 2016.9Reviewed

Naoki Kaneko, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Taiki Sakamoto, Yuma Hashiguchi, Masakazu Iida, Seiji Nakamura . Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte-colony-stimulating factor . World Journal of Surgical Oncology14 ( 1 ) 161 2016.6Reviewed

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Papers - Yuichi Goto