Updated on 2024/11/28

写真a

 
 
Organization
University Hospital, Medical and Dental Sciences Area University Hospital Clinical Center Cardiovascular Center Lecturer
Title
Lecturer

Degree

  • 博士(医学) ( 2010.4   鹿児島大学 )

Research Areas

  • Others / Others  / 心エコー

  • Others / Others  / 肺高血圧

Research History

  • Kagoshima University   Medical and Dental Hospital, Medical and Dental Sciences Area Medical and Dental Hospital Clinical Center Cardiovascular Center   Lecturer

    2018.4

  • Kagoshima University   Medical and Dental Hospital, Medical and Dental Sciences Area Medical and Dental Hospital Clinical Center Cardiovascular Center   Assistant Professor

    2003.4 - 2018.3

Professional Memberships

  • 日本心臓病学会

    2005.4

  • 日本超音波医学会

    2005.4

  • 日本心エコー図学会

    2005.4

  • 日本循環器学会

    2004.9

  • 日本内科学会

    2001.10

 

Papers

  • Nakamura J, Tsujino I, Masaki K, Hosokawa K, Funakoshi K, Taniguchi Y, Adachi S, Inami T, Yamashita J, Ogino H, Hatano M, Yaoita N, Ikeda N, Shimokawahara H, Tanabe N, Kubota K, Shigeta A, Ogihara Y, Horimoto K, Dohi Y, Kawakami T, Tamura Y, Tatsumi K, Abe K .  Cancer as an independent mortality risk in chronic thromboembolic pulmonary hypertension .  J Heart Lung Transplant.   2024.10Cancer as an independent mortality risk in chronic thromboembolic pulmonary hypertensionReviewed

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  • Masaki K, Hosokawa K, Funakoshi K, Taniguchi Y, Adachi S, Inami T, Yamashita J, Ogino H, Tsujino I, Hatano M, Yaoita N, Ikeda N, Shimokawahara H, Tanabe N, Kubota K, Shigeta A, Ogihara Y, Horimoto K, Dohi Y, Kawakami T, Tamura Y, Tatsumi K, Abe K; CTEPH AC Registry Study Group .  Outcomes of Chronic Thromboembolic Pulmonary Hypertension After Balloon Pulmonary Angioplasty and Pulmonary Endarterectomy .  JACC Asia.4 ( 8 ) 577 - 589   2024.7Outcomes of Chronic Thromboembolic Pulmonary Hypertension After Balloon Pulmonary Angioplasty and Pulmonary EndarterectomyReviewed

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  • Shimokawahara H., Inami T., Kubota K., Taniguchi Y., Hashimoto H., Saito A.M., Sekimizu M., Matsubara H. .  Protocol for a multicentre, double-blind, randomised, placebo-controlled trial of riociguat on peak cardiac index during exercise in patients with chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty (THERAPY-HYBRID-BPA trial) .  BMJ Open13 ( 7 ) e072241   2023.7

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    Language:Japanese   Publisher:BMJ Open  

    Objectives Balloon pulmonary angioplasty (BPA) and medical therapy, such as soluble guanylate cyclase stimulators, are recommended treatments for patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are ineligible for pulmonary endarterectomy (PEA). However, monotherapy with BPA or medical therapy cannot always eliminate symptoms such as exertional dyspnoea. Thus, this study aims to clarify the efficacy of continuous treatment with riociguat in inoperable CTEPH patients with normalised haemodynamics after BPA. Methods and analysis This is a double-blind, multicentre, randomised, placebo-controlled trial. Participants with CTEPH who are ineligible for PEA will receive riociguat followed by BPA. Subsequently, participants will be randomised (1:1) into either riociguat continuing or discontinuing groups and will be observed for 16 weeks after randomisation. The primary endpoint will be the change in peak cardiac index (CI) during the cardiopulmonary exercise test. In the primary analysis, the least square mean differences and 95% CIs for the change in peak CI at 16 weeks between the groups will be estimated by a linear mixed-effects model with baseline value as a covariate, treatment group as a fixed effect and study institution as a random effect. Ethics and dissemination National Hospital Organisation Review Board for Clinical Trials (Nagoya) and each participating institution approved this study and its protocols. Written informed consent will be obtained from all participants. The results will be disseminated at medical conferences and in journal publications. Registration details Japan Registry of Clinical Trials: jRCT no. 041200052. ClinicalTrials.gov by National Library of Medicine Registry ID: NCT04600492. Trial registration number NCT04600492.

    DOI: 10.1136/bmjopen-2023-072241

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  • Kubota K., Miyanaga S., Akao M., Mitsuyoshi K., Iwatani N., Higo K., Ohishi M. .  Association of delayed diagnosis of pulmonary arterial hypertension with its prognosis .  Journal of Cardiology   2023

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    Language:Japanese   Publisher:Journal of Cardiology  

    Background: Currently, pulmonary hypertension-targeted therapy has been shown to improve the survival of patients with pulmonary artery hypertension (PAH). However, the importance of early diagnosis has not been investigated. Therefore, this study aimed to investigate whether a delayed diagnosis of PAH is associated with its prognosis. Methods and results: A total of 66 consecutive untreated patients were diagnosed with PAH from January 2008 to December 2021 at the Kagoshima University Hospital. The time from symptom onset to diagnosis correlated with brain natriuretic peptide levels (p < 0.001), right ventricle (RV) Tei index (p < 0.001), and the tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio (p = 0.003). These findings suggest that in patients with PAH, RV function declines with increasing time from symptom onset to diagnosis. Furthermore, older patients with PAH appeared to have a longer time from symptom onset to diagnosis. Next, patients were divided into delayed diagnosis (>3 months) and early diagnosis (≤3 months) groups based on the time from symptom onset to diagnosis. Patients were categorized into three groups according to the European Society of Cardiology (or the European Respiratory Society) risk stratification guidelines. Patients diagnosed with PAH within 3 months of symptom onset were significantly in the low- or intermediate-risk groups (p < 0.001). A Kaplan-Meier analysis revealed that the cumulative event-free rate was significantly lower (p < 0.01) in the delayed diagnosis group than in the early diagnosis group. A delayed diagnosis was significantly associated with a worse outcome than an early diagnosis, after adjusting for different sets of confounding factors. Conclusions: A delayed PAH diagnosis is associated with a poor prognosis. Early diagnosis of PAH may lead to a low-risk treatment. Furthermore, older patients need more careful screening for PAH.

    DOI: 10.1016/j.jjcc.2023.08.004

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  • Iwatani N, Kubota K, Ikeda Y, Tokushige A, Miyanaga S, Higo K, Ohishi M .  Different characteristics of mitochondrial dynamics-related miRNAs on the hemodynamics of pulmonary artery hypertension and chronic thromboembolic pulmonary hypertension .  J Cardiol 78 ( 1 ) 24 - 30   2021.7

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    Language:Japanese   Publisher:Journal of Cardiology  

    Background: Mitochondria are dynamic organelles that undergo fission or fusion. These mitochondrial dynamics are reported to be associated with pulmonary hypertension (PH). PH is divided into 5 groups, including pulmonary artery hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH), based on its pathogenesis. However, it is still unknown whether and how miRNAs related to mitochondrial dynamics (MD) affect PAH and CTEPH. Methods: We investigated patients who underwent right heart catheterization between October 2016 and January 2019. Out of 34 PH patients, 12 were diagnosed with PAH, and 22 were diagnosed with CTEPH. In addition, there were 30 patients diagnosed with left heart disease. We enrolled the 34 PH patients as the PH group and 30 left heart disease patients as the control group. Results: Among MD-related miRNAs, the circulating levels of miR-140-3p were higher, and those of miR-485-5p were lower in the PH group than in the control group (p < 0.01), suggesting that miRNAs inducing mitochondrial fission are related to PH. The miR-140-3p levels in the PAH and CTEPH groups were higher than those in the control group (p < 0.01). The levels of miR-140-3p and miR-485-5p in the PAH group correlated with pulmonary vascular resistance (r = 0.582, p = 0.046) and cardiac index (r = −0.36, p = 0.04), respectively. The miR-485-5p levels in the CTEPH group correlated with right atrium pressure (r = −0.456, p = 0.049). Conclusion: MD-related miRNAs levels change to induce fission and are closely related to the hemodynamics of PAH and CTEPH.

    DOI: 10.1016/j.jjcc.2021.03.008

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  • Akagi S, Dohi Y, Ishikawa K, Kubota K, Horimoto K, Yagi S, Hirata T, Yamamoto E, Ito H, Nakamura K .  Effects of Dual Initial Combination Therapy With Macitentan Plus Riociguat or Macitentan Plus Selexipag on Hemodynamics in Patients With Pulmonary Arterial Hypertension (SETOUCHI-PH Study) - Protocol of a Multicenter Randomized Control Trial. .  Circ Rep .3 ( 2 ) 105 - 109   2021.1Effects of Dual Initial Combination Therapy With Macitentan Plus Riociguat or Macitentan Plus Selexipag on Hemodynamics in Patients With Pulmonary Arterial Hypertension (SETOUCHI-PH Study) - Protocol of a Multicenter Randomized Control Trial.

  • Kubota K, Miyanaga S, Iwatani N, Higo K, Tokushige A, Ikeda Y, Ohishi M. .  Geriatric nutritional risk index is associated with prognosis in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. .  Circ Rep2 ( 7 ) 372 - 377   2020.7Geriatric nutritional risk index is associated with prognosis in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circrep.CR-20-0046

  • Ojima S, Kubozono T, Saihara K, Miyauchi T, Kawasoe S, Kubota K, Shigemizu S, Ohtsubo H, Miyata M, Ohishi M. .  Significant clinical indexes of exercise-induced pulmonary hypertension in patients with connective tissue disease. .  Circ Rep.1 ( 12 ) 610 - 616   2019.11Significant clinical indexes of exercise-induced pulmonary hypertension in patients with connective tissue disease.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circrep.CR-19-0087

  • Miyanaga S, Kubota K, Iwatani N, Higo K, Miyata M, Horizoe Y, Ojima S, Kawasoe S, Kubozono T, Ohishi M. .  Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease. .  Heart Vessels34 ( 9 ) 1509 - 1518   2019.9Predictors of exercise-induced pulmonary hypertension in patients with connective tissue disease.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00380-019-01373-6

  • Uchiyama N, Yuasa T, Miyata M, Horizoe Y, Chaen H, Kubota K, Takasaki K, Mizukami N, Kisanuki A, Ohishi M. .  Correlation of right ventricular wall stress with plasma B-type natriuretic peptide levels in patients with pulmonary hypertension. .  Circ J83 ( 6 ) 1278 - 1285   2019.5Correlation of right ventricular wall stress with plasma B-type natriuretic peptide levels in patients with pulmonary hypertension.

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  • Horizoe Y, Takasaki K, Miyata M, Chaen H, Kubota K, Mizukami N, Yuasa T, Kisanuki A, Ohishi M. .  Analysis of biphasic right ventricular outflow doppler waveform in patients with pulmonary hypertension: Estimation of pulmonary vascular resistance .  Int Heart J.60 ( 1 ) 108 - 114   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:International Heart Journal  

    DOI: 10.1536/ihj.18-149

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  • Higo K, Kubota K, Miyanaga S, Miyata M, Nakajo M, Jinguji M, Ohishi M. .  Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension. .  Int Heart J.59 ( 1 ) 112 - 119   2018.1Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1536/ihj.16-629

  • Higo K, Kubota K, Takeda A, Higashi M, Ohishi M. .  Successful Antemortem Diagnosis and Treatment of Pulmonary Tumor Thrombotic Microangiopathy. .  Intern Med 53   2595 - 2599   2014Successful Antemortem Diagnosis and Treatment of Pulmonary Tumor Thrombotic Microangiopathy.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Kubota K, Otsuji Y, Ueno T, Koriyama C, Levine RA, Sakata R, Tei C. .  Functional mitral stenosis after surgical annuloplasty for ischemic mitral regurgitation: importance of subvalvular tethering in the mechanism and dynamic deterioration during exertion. .  J Thorac Cardiovasc Surg.140 ( 3 ) 617 - 623   2010.1Functional mitral stenosis after surgical annuloplasty for ischemic mitral regurgitation: importance of subvalvular tethering in the mechanism and dynamic deterioration during exertion.Reviewed

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MISC

  • Pulmonary artery hypertension-associated with human immunodeficiency virus infection with attenuated effect of subcutaneous treprostinil injection during long-term observation: A case report

    Miyanaga S, Kubota K, Iwatani N, Akao M, Mitsuyoshi K, Ohishi M.

    Journal of Cardiology Cases   28 ( 2 )   72 - 74   2023.8

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    Pulmonary artery hypertension associated with human immunodeficiency virus infection (PAH-HIV) is known to be caused by HIV infection. Antiretroviral therapy and PAH-specific drugs improve the prognosis of patients with PAH-HIV, but the pathophysiology of PAH-HIV remains unclear. We report a case of PAH-HIV treated with upfront combination therapy including subcutaneous injection of treprostinil. One year after treatment initiation, the patient's PAH improved significantly. However, it worsened over time due to reduced efficacy of subcutaneous injection of treprostinil. Learning objective: The etiology and pathophysiology of pulmonary artery hypertension associated with human immunodeficiency virus infection (PAH-HIV) remain unclear, and there are few case reports of PAH-HIV in Japan because the HIV prevalence is low. We encountered a case of PAH-HIV in which the efficacy of subcutaneous treprostinil injection was attenuated. It was unclear whether the reduced efficacy was associated with the pathophysiology of PAH-HIV. When PAH control deteriorates, early alteration of medication choice and administration route is important.

    DOI: 10.1016/j.jccase.2023.04.008

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  • シリーズ循環器 (第7回) 肺高血圧症の診断と治療.

    窪田佳代子.

    鹿児島県医師会報   865   63 - 66   2023.7

  • Unknown atrial septal defect was diagnosed during the course of treatment for portopulmonary hypertension: a case report

    Kubota K, Miyanaga S, Iwatani N, Ohishi M.

    J Cardiol Cases.   26 ( 5 )   383 - 385   2022.11

  • 右室拡大・右室肥大評価の指標.

    窪田佳代子.

    月刊「心エコー」   22   1062 - 1067   2021

  • The potential for early diagnosis of pulmonary arterial hypertension using lung iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake: a case report

    Higo K, Kubota K, Hiwatari Takeshita S, Iwatani N, Minayaga S, Jinguji M, Ohishi M

    Radiol Case Rep   15 ( 8 )   1164 - 1167   2020.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1016/j.radcr.2020.05.036

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  • Successful treatment of POEMS syndrome-associated pulmonary hypertension with lenalidomide and dexamethasone therapy

    NAKAMURA Daisuke, HAYASHIDA Maiko, KUBOTA Kayoko, MATSUURA Eiji, TABUCHI Tomohisa, ARIMA Naosuke, INOUE Hirosaka, YOSHIMITSU Makoto, ISHITSUKA Kenji

    Rinsho Ketsueki   59 ( 5 )   489 - 491   2018

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    Publisher:The Japanese Society of Hematology  

    <p>POEMS syndrome is often complicated by pulmonary hypertension. The standard therapy for patients with POEMS syndrome is high-dose chemotherapy followed by autologous stem cell transplantation. However, the safety of high-dose chemotherapy for patients complicated with pulmonary hypertension remains unclear, and the optimal therapy for these patients is yet to be establishment. Herein, we report the case of a 54-year-old woman with POEMS syndrome accompanied by pulmonary hypertension. We successfully and safely performed lenalidomide and dexamethasone (Ld) therapy followed by high-dose chemotherapy and autologous stem cell transplantation, which improved her pulmonary hypertension. Thus, Ld can be considered as safe and effective for pulmonary hypertension with POEMS syndrome.</p>

    DOI: 10.11406/rinketsu.59.489

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Presentations

  • 木原彩貴, 窪田佳代子, 赤尾光優, 光吉こころ, 宮永 直, 大石 充   社会的障壁を有した特発性肺動脈性肺高血圧症の一例.  

    第134回 日本循環器学会九州地方会  2023.6 

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    Event date: 2023.6

    Venue:熊本市  

  • Akao M, Mitsuyoshi K, Miyanaga S, Kubota K, Ohishi M   Association of delayed pulmonary arterial hypertension diagnosis with prognostic predictor  

    第87回 日本循環器学会学術集会  2023.8 

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    Event date: 2023.3

    Venue:福岡市  

  • 木原悠起, 赤尾光優, 光吉こころ, 宮永 直, 窪田佳代子, 大石 充.   部分肺静脈還流異常症に伴う肺動脈性肺高血圧症に対しTreat and Repairを実施した一症例.  

    第133回 日本循環器学会九州地方会 

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    Event date: 2022.12

    Venue:久留米市  

  • 赤尾光優, 宮永 直, 窪田佳代子, 大石 充.   肺動脈性肺高血圧症における早期診断の有用性についての検討  

    第70回 日本心臓病学会学術集会 

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    Event date: 2022.9

    Venue:京都市  

  • 赤尾光優, 光吉こころ, 宮永 直, 窪田佳代子, 大石 充.   CPFE-severe PHに対しupfront combination therapyを行った一例  

    第7回 日本肺高血圧・肺循環学会学術集会 

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    Event date: 2022.7

    Venue:東京  

  • 宇都宮麻子, 岩谷徳子, 宮永 直, 窪田佳代子, 大石 充.   シェーグレン症候群の味覚異常によりるいそうを来した一例  

    医学生・研修医の日本内科学会ことはじめ 2022 京都 

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    Event date: 2022.4

    Venue:京都市  

  • 窪田佳代子.   モーニングセミナー. 肺高血圧症診療における診療連携の重要性.  

    第25回 日本心不全学会学術集会 

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    Event date: 2021.10

  • 岩谷徳子, 窪田佳代子, 池田義之, 宮永 直, 大石 充.   肺動脈性肺高血圧症と慢性血栓塞栓性肺高血圧症におけるミトコンドリアダイナミクス関連miRNA発現の相違.  

    第69回 日本心臓病学会学術集会 

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    Event date: 2021.9

  • 下園夏帆, 宮永直, 岩谷徳子, 窪田佳代子, 大石 充.   臨床症状と画像診断から早期生前診断に至ったPTTMの一例.  

    第6回 日本肺高血圧・肺循環学会学術集会 

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    Event date: 2021.5

  • 窪田佳代子.   共催セミナー. 肺高血圧症を見逃さないために.  

    第6回 日本肺高血圧・肺循環学会学術集会 

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    Event date: 2021.5

  • Iwatani N, Kubota K, Ikeda Y, Miyanaga S, Ohishi M.   Notable participation of mitochondrial dynamics-related mirna in the pathophysiology of pulmonary hypertension.  

    第 85 回 日本循環器学会学術集会  

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    Event date: 2021.3

  • 岩谷徳子, 宮永 直, 窪田佳代子, 徳重明央, 池田義之, 大石 充.   女性研究者奨励賞セッション.Mitochondrial fission-related miRNAs Plays a role in the etiology of pulmonary artery diseases.  

    第129回 日本循環器学会九州地方会 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Iwatani N, Kubota K, Ikeda Y, Miyanaga S, Tokushige A, Ohishi M.   Mitochondrial fission-related miRNAs plays a role in the etiology of pulmonary artery diseases   International conference

    The American Heart Association’s Scientific Sessions 2020 

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    Event date: 2020.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Dallas, USA  

  • 林 真生, 宮永 直, 岩谷徳子, 窪田佳代子, 大石 充.   肺高血圧症を合併した衝心脚気の一例.  

    第5回 日本肺高血圧・肺循環器学会学術集会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 窪田佳代子   ランチョンセミナー. 肺動脈性肺高血圧症における早期診断の重要性.  

    日本心エコー図学会 第31回 学術集会 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  • 宮永 直, 岩谷徳子, 窪田佳代子, 大石 充.   当院で経験した高齢独居CTEPHの1例.  

    第30回 日本老年医学会九州地方会 

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    Event date: 2020.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:誌上開催  

  • 伊比隆輔,窪田佳代子,岩谷徳子,宮永 直,大石 充.   研修医セッション. 診断時に続発性気胸を併発していたCTEPHの1例.  

    第127回 日本循環器学会九州地方会 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米市  

  • 窪田佳代子.   内科・外科連携セッション. 心エコーによる右心機能評価.  

    第127回 日本循環器学会九州地方会 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米市  

  • 宮永 直,岩谷徳子,窪田佳代子,大石 充.   Treat and Repairを行った肺高血圧症合併心房中隔欠損症の2例.  

    第67回 日本心臓病学会学術集会 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  • 岩谷徳子,宮永 直,窪田佳代子,大石 充.   CTEPHの治療経過中にCVポートの血栓形成を認めた2症例.  

    第4回 日本肺高血圧・肺循環器学会学術集会 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松市  

  • 窪田佳代子.   イブニングセミナー. 肺高血圧症治療の現状とこれから:当科における診療連携の実際.  

    第4回 日本肺高血圧・肺循環器学会学術集会 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松市  

  • 中尾周平,宮永 直,岩谷徳子,窪田佳代子.   肺移植後に身体活動の長期変化を観察した肺高血圧症患者の1例.  

    第4回 日本肺高血圧・肺循環器学会学術集会 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松市  

  • 窪田佳代子.   パネルディスカッション4. 右心機能の評価法と右心不全の治療. 肺高血圧症における右室機能評価.   International conference

    第22回 日本心不全学会学術集会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京  

  • 窪田佳代子.   会長特別企画 ケースに学ぶ2. 肺高血圧症を診つけよう. PHの症状と病態, おこるしくみ, なぜ診断が遅れてしまうのか?  

    第66回 日本心臓病学会学術集会 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:大阪  

  • 肥後建樹郎, 窪田佳代子, 宮永 直, 岩谷徳子, 大石 充.   PGI2製剤の切り替えが有効であったPAHの一症例.  

    第66回 日本心臓病学会学術集会 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:大阪  

  • 宮永 直, 窪田佳代子, 岩谷徳子, 肥後建樹郎, 宮田昌明, 堀添善尚, 小島聡子, 川添 晋, 窪薗琢郎, 大石 充.   YIA臨床研究 (CR) セッション. 膠原病患者における運動誘発性肺高血圧症の非侵襲的予測因子の検討.  

    第124回 日本循環器学会九州地方会 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:鹿児島  

  • 堀添善尚, 髙﨑州亜, 宮田昌明, 窪田佳代子, 水上尚子, 湯淺敏典, 木佐貫 彰, 大石 充.   Analysis of biphasic right ventricular outflow Doppler waveform in patients with pulmonary hypertension; estimation of pulmonary vascular resistance.  

    第82回 日本循環器学会学術集会 

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    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:大阪  

  • Iwatani N, Kubota K, Miyanaga S, Ohishi M.   Mean pulmonary arterial pressure at final balloon pulmonary angiop lasty predicts the improvement of exercise capacity after one-year in CTEPH patients.   International conference

    ACC 67th Annual Scientific Session 

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    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Orlando, USA  

  • 岩谷徳子, 窪田佳代子, 宮永 直, 大石 充.   Mean pulmonary arterial pressure at final balloon pulmonary angiop lasty predicts the improvement of exercise capacity after one-year in CTEPH patients.  

    第82回 日本循環器学会学術集会 

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    Event date: 2018.3

    Language:English   Presentation type:Poster presentation  

    Venue:大阪  

  • 沖野秀人, 窪田佳代子, 岩谷徳子, 宮永 直, 大石 充, 浜田平一郎.   ダサチニブ使用により遅発性に出現した肺高血圧症の1例.  

    日本内科学会 第320回 九州地方会 

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    Event date: 2018.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡  

  • 内山奈美, 堀添善尚, 茶圓秀人, 窪田佳代子, 水上尚子, 髙﨑州亜, 湯淺敏典, 木佐貫 彰, 大石 充.   肺高血圧症例における右房圧の推定に吸気時下大静脈径および下大静脈 collapsibility indexは有 用である.  

    日本超音波医学会 第27回 九州地方会 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島  

  • 中尾周平, 吉田 輝, 長谷場純仁, 窪薗琢郎, 窪田佳代子.   肺動脈性肺高血圧症患者に対する吸気筋トレーニングを含む理学療法の有効性についての検討.  

    第3回 日本心臓リハビリテーション学会九州地方会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:鹿児島  

  • 手塚綾乃, 肥後建樹郎, 岩川良彦, 俵積田光宏, 福迫 剛, 窪田佳代子, 大石 充.   肺高血圧症を合併した重症の関節リウマチ患者にリハビリテーションを行った一症例.  

    第3回 日本心臓リハビリテーション学会九州地方会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島  

  • 岩谷徳子, 宮永 直, 窪田佳代子, 大石 充.   門脈肺高血圧症の治療経過で心房中隔欠損症が判明した1例.  

    第65回 日本心臓病学会学術集会 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪  

  • 宮永 直, 岩谷徳子, 窪田佳代子, 大石 充.   HIV-related PAHに対してcombination therapyを行った一例.  

    第2回 日本肺高血圧・肺循環学会学術集会 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌  

  • 町頭郁哉, 窪田佳代子, 岩谷徳子, 宮永 直, 大石 充.   側弯症に合併した肺高血圧症の一例.  

    日本内科学会 第317回 九州地方会 

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    Event date: 2017.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄  

  • 堀添善尚, 髙﨑州亜, 宮田昌明, 湯淺敏典, 茶圓秀人, 窪田佳代子, 水上尚子, 木佐貫 彰, 大石 充.   The novel index for estimation of markedly elevated pulmonary vascular resistance in patients with pulmonary hypertension.  

    第81回 日本循環器学会総会・学術集会 

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    Event date: 2017.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:石川  

  • 窪田佳代子.   Luncheon seminar 39. 肺高血圧症を見逃さない:早期診断/治療・医療連携の重要性.  

    第81回 日本循環器学会総会・学術集会 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:石川  

  • Miyanaga S, Kubota K, Iwatani N, Higo K, Horizoe Y, Chaen H, Uchiyama N, Ojima S, Kawasoe S, Kubozono T, Miyata M, Ohishi M.   Determinants of exercise tolerance after balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension.   International conference

    AHA Scientific Sessions 2016 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:New Orleands, USA  

  • 肥後建樹郎, 窪田佳代子, 宮永 直, 宮田昌明, 大石 充.   123I-MIBGシンチを用いた肺高血圧症における肺血管内皮機能検査.  

    第64回 日本心臓病学会学術集会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

  • 小島聡子, 窪薗琢郎, 川添 晋, 窪田佳代子, 才原啓司, 肥後建樹郎, 重水早苗, 大坪秀雄, 宮内孝浩, 宮田昌明, 大石 充.   膠原病患者における運動誘発性肺高血圧症は最高酸素摂取量と関連する.  

    第22回 日本心臓リハビリテーション学会学術集会 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Higo K, Kubota K, Miyanaga S, Miyata M, Nakajo M, Jinguji M, Ohishi M.   Novel diagnostic tool of PAH: Lung 123I-MIBG scintigraphy.   International conference

    ACC 65th. Annual Scientific Session 

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    Event date: 2016.4

    Language:English  

    Venue:Chicago, USA  

    国際学会

  • 宇佐美 環, 小島聡子, 川添 晋, 窪薗琢郎, 入來泰久, 桶谷直也, 窪田佳代子, 樋口公嗣, 宮田昌明, 大石 充.   同胞で異なる左室機能障害の進行を示したベッカー型筋ジストロフィー症例.  

    第113回 日本内科学会総会・講演会 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

  • 岩谷徳子, 窪田佳代子, 宮永 直, 肥後建樹郎, 大石 充.   高齢者難病疾患患者のターミナルケア.  

    第26回 日本老年医学会九州地方会 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島  

  • Chaen H, Yuasa T, Horizoe Y, Ueya N, Miyanaga S, Kubota K, Mizukami N, Takasaki K, Miyata M, Kisanuki A, Ohishi M.   The chronic effect of balloon pulmonary angioplasty on right ventricular function in patients with chronic thromboembolic pulmonary hypertension.  

    第80回 日本循環器学会学術集会 

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    Event date: 2016.3

    Language:Japanese  

    Venue:宮城  

    国内学会

  • 園田智洋, 桑波田 聡, 辻 紘明, 長友理笑, 迫田 隆, 竹中俊宏, 宮永 直, 岩谷徳子, 窪田佳代子, 安部 智, 大石 充.   右心不全の原因診断に苦慮した1例.  

    鹿屋地区内科医会症例検討会 

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    Event date: 2016.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿屋市  

  • 小島聡子, 窪薗琢郎, 嘉川亜希子, 川添 晋, 重水早苗, 大坪秀雄, 才原啓司, 窪田佳代子, 宮田昌明, 宮内孝浩, 大石 充.   膠原病患者における運動誘発性肺高血圧に関する検討.  

    第9回 日本性差医学・医療学会学術集会 

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    Event date: 2016.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌  

  • 飯尾梨沙, 徳重明央, 鎌田博之, 内匠拓朗, 窪田佳代子, 宮田昌明, 大石 充.   薬剤アレルギーにより治療に難渋した閉塞性肥大型心筋症の1例.  

    第119回 日本循環器学会九州地方会 

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    Event date: 2015.12

    Language:Japanese  

  • Horizoe Y, Takasaki K, Chaen H, Ueya N, Kubota K, Mizukami N, Yuasa T, Miyata M, Kisanuki A, Ohishi M.   Biphasic right ventricular Doppler velocity parameters can evaluate pulmonary vascular resistance in patients with pulmonary hypertension.   International conference

    AHA Scientific Sessions 2015 

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    Event date: 2015.11

    Language:English   Presentation type:Oral presentation (general)  

  • Chaen H, Yuasa T, Horizoe Y, Ueya N, Kubota K, Mizukami N, Takasaki K, Miyata M, Kisanuki A, Ohishi M.   The chronic effect of balloon pulmonary angioplasty on right ventricular function in patients with chronic thromboembolic pulmonary hypertension.   International conference

    AHA Scientific Sessions 2015 

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    Event date: 2015.11

    Language:English  

  • 有村俊博, 窪薗琢郎, 川添 晋, 入來泰久, 桶谷直也, 内匠拓朗, 鎌田博之, 窪田佳代子, 宮田昌明, 大石 充.   Peutz-Jeghers症候群に左心機能不全を合併した1例.  

    第311回日本内科学会九州地方会  

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎  

  • 宮永 直, 肥後建樹郎, 田中佳代子, 大石 充.   IgG4高値を伴う肺高血圧症にステロイドが有効であった一例.  

    第63回 日本心臓病学会学術集会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川  

  • 鮫島光平, 宮永 直, 肥後建樹郎, 窪田佳代子, 大石 充.   褐色細胞腫を伴うEisenmenger症候群に対しBosentan導入を行った1例.  

    第310回 日本内科学会九州地方会 

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    Event date: 2015.8

    Language:English  

  • 中尾周平, 榊間春利, 長谷場純仁, 吉田 輝, 窪薗琢郎, 窪田佳代子.   当院での肺高血圧患者に対するリハビリテーションの現状と今後の展望について ~症例検討を中心に~  

    第21回日本心臓リハビリテーション学会学術集会 

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    Event date: 2015.7

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 小島聡子, 窪薗琢郎, 川添 晋, 才原啓司, 窪田佳代子, 宮田昌明, 宮内孝浩, 大石 充.   膠原病患者における運動誘発性肺高血圧に関する検討.  

    第21回日本心臓リハビリテーション学会学術集会 

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    Event date: 2015.7

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 窪田佳代子.   肺高血圧症診療における心エコー図の役割.  

    第26回 日本心エコー図学会学術集会 

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    Event date: 2015.3

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 中村幸美, 水上尚子, 野口慶久, 湯之上真吾, 前之園隆一, 大園七瀬, 小林沙織, 髙﨑州亜, 湯淺敏典, 植屋奈美, 茶圓秀人, 窪田佳代子, 木佐貫 彰.   典型的な左室緻密化障害.  

    第26回 日本心エコー図学会学術集会 

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    Event date: 2015.3

    Language:English  

  • 肥後建樹郎, 窪田佳代子, 武田綾乃, 宮永 直, 東 美智代, 大石 充.   生前の確定診断後に分子標的薬で加療し救命できたPTTM(Pulmonary Tumor Thrombotic Microangiopathy)の一例.  

    第62回 日本心臓病学会学術集会 

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    Event date: 2014.9

    Language:Japanese  

    Venue:宮城  

    国内学会

  • Ueya N, Yuasa T, Horizoe Y, Chaen H, Kubota K, Takasaki K, Mizukami N, Kisanuki A, Ohishi M.   Right ventricular end diastolic wall stress correlates with plasma B-type natriuretic peptide level in patients with pulmonary hypertension.   International conference

    European Society of Cardiology (ESC) Congress 2014 

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    Event date: 2014.8

    Language:English  

    Venue:スペイン  

    国際学会

  • Takasaki K, Tokushige A, Takumi T, Kubota K, Ohishi M.   Case-based learning in Adult Congenital Heart Disease-2.Segmental pulmonary artery hypertension in a patient with repaired ventricular septal defect, pulmonary atresia and major aortopulmonary collateral arteries (MAPCAs).  

    1st Actelion Academic Forum in Pulmonary Hypertension 

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    Event date: 2014.7

    Language:Japanese  

    Venue:東京  

    研究会

  • 田中佳代子   ランチョンセミナー3.肺高血圧症の診断と最近の治療について.  

    第35回 日本循環制御医学会総会 

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    Event date: 2014.7

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 毛利翔悟, 肥後建樹郎, 窪田佳代子, 髙﨑州亜, 大石 充.   ミトコンドリア病に肺高血圧症を合併した1例.  

    第305回 日本内科学会九州地方会 

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    Event date: 2014.5

    Language:Japanese  

    Venue:熊本  

    国内学会

  • 堀添善尚, 髙﨑州亜, 植屋奈美, 茶圓秀人, 窪田佳代子, 水上尚子, 湯淺敏典, 木佐貫 彰, 大石 充.   肺高血圧症合併の単心房術後残存シャント根治術術前後を心エコーで観察し得た一例.  

    第87回 日本超音波医学会学術集会 

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    Event date: 2014.5

    Language:Japanese  

    Venue:神奈川  

    国内学会

  • 堀添善尚, 髙﨑州亜, 毛利翔悟, 徳重明央, 植屋奈美, 茶圓秀人, 窪田佳代子, 水上尚子, 湯淺敏典, 宮田昌明, 木佐貫 彰, 大石 充.   心臓原発滑膜肉腫と思われた右房内腫瘍の一例.  

    第25回 日本心エコー図学会学術集会 

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    Event date: 2014.4

    Language:Japanese  

    Venue:石川  

    国内学会

  • Ojima S, Saihara K, Hamasaki S, Oketani N, Okui H, Kubozono T, Kubota K, Takumi T, Kanda D, Iriki Y, Tokushige A, Higo K, Takano S, Matsuda T, Oishi M.   Role of Mastication Frequency for Favorable Cardiovascular Prognosis.  

    第78回 日本循環器学会総会・学術集会 

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    Event date: 2014.3

    Language:Japanese  

    Venue:東京  

    国内学会

  • 窪田佳代子.   シンポジウム8: 弁膜症の診断と治療: 虚血性僧帽弁逆流に対する弁輪形成術後の機能性僧帽弁狭窄.  

    第85回 日本超音波医学会学術集会 

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    Event date: 2012.5

    Language:Japanese  

    Venue:東京  

    国内学会

  • 窪田佳代子   パネルディスカッション5: 急性心筋梗塞の予後評価に心エコーを役立てる: 虚血性僧帽弁逆流における運動負荷心エコーの意義: 弁輪形成術施行例における検討.  

    第23回 日本心エコー図学会学術集会 

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    Event date: 2012.4

    Language:Japanese  

    Venue:大阪  

    国内学会

  • 窪田佳代子   虚血性僧帽弁逆流に対する弁輪形成術後の機能性僧帽弁狭窄  

    第59回 日本心臓病学会学術集会  2011.9 

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    Event date: 2011.9

    Language:Japanese  

    Venue:兵庫  

    国内学会

  • Kubota K, Otsuji Y, Yoshifuku S, Ueno T, Kuwahara E, Takasaki K, Nakanishi K, Uemura T, Kono M, Mizukami N, Kisanuki A, Sakata R, Tei C   Association of recurrent ischemic mitral regurgitation and functional mitral stenosis by systolic and diastolic tethering after surgical annuloplasty.   International conference

    19th Annual Scientific Session of the America Society of Echocardiography 

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    Event date: 2008.6

    Language:English  

    Venue:カナダ  

    国際学会

  • Kubota K, Otsuji Y, Ueno T, Maki Y, Kuwahara E, Mizukami N, Miyata M, Hamasaki S, Kisanuki A, Minagoe S, Levine RA, Sakata R, Tei C   Functional mitral stenosis following surgical annuloplasty for ischemic mitral regurgitation.   International conference

    55th Annual Scientific Session of the America College of Cardiology 2006 

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    Event date: 2006.3

    Language:English  

    Venue:アメリカ  

    国際学会

  • 光吉こころ, 赤尾光優, 宮永 直, 窪田佳代子, 大石 充, 上田英昭, 曽我欣治.   急性肺塞栓症治療中に卵円孔開存に嵌頓した巨大血栓を認め, 緊急手術にて動脈塞栓症を回避し得た一例  

    第134回 日本循環器学会九州地方会  2023.6 

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    Venue:熊本市  

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Research Projects

  • 定量肺血流SPECT/CTと機械学習による肺高血圧症診断法の開発.(分担)

    2022.4 - 2025.3

    日本学術振興会科学研究助成  基盤研究C

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4160000

  • 肺高血圧症の進行抑制を目的としたフレイルサイクルの多角的評価と介入治療の検討.

    2021.4 - 2024.3

    日本学術振興会科学研究助成  基盤研究C

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    Authorship:Principal investigator 

    Grant amount:\2470000

  • 慢性血栓塞栓性肺高血圧症に関する多施設共同レジストリ研究.

    2018.4 - 2021.3

    厚生労働省  科学技術振興調整費 

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    Grant type:Competitive

  • 次世代シーケンサーによる家族性肺高血圧症の遺伝子解析:特発性肺高血圧症の機序解明.

    2017.4 - 2020.3

    科学研究費補助金  基盤研究(C)

 

Social Activities

  • 肺高血圧症WEB市民公開講座

    Role(s): Lecturer

    2022.2

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    Type:Internet

    肺高血圧症を知ろう!

  • 長岡画像からみる肺高血圧症

    Role(s): Lecturer

    2017.12

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    日常臨床に潜む肺高血圧症.

  • PHセミナーin KANOYA

    Role(s): Lecturer

    鹿屋市  2017.11

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    日常臨床に潜むPAHとフォローアップの重要性.

  • 大分県PAH研究会

    Role(s): Lecturer

    鹿屋市  2017.11

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    PAH診療ネットワークの構築:膠原病の病診連携を含めて.

  • 第2回 熊本肺高血圧症寺子屋セミナー

    Role(s): Lecturer

    熊本  2017.10

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    肺高血圧診療における地域連携の重要性.

  • PH Seminar in岡山

    Role(s): Lecturer

    岡山  2017.10

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    重度の視力障害を有するPAH症例.

  • 肺動脈性肺高血圧症学術講演会in 福岡

    Role(s): Lecturer

    福岡  2017.8

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    当院でのPH治療における地域医療連携活動と薬物治療.

  • 第8回PH-CHDクリニカルカンファレンス

    Role(s): Lecturer

    大阪  2017.8

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    肺高血圧症のトータルケア.

  • 4th Actelion Academic Forum on Pulmonary Hypertension

    Role(s): Lecturer

    京都  2017.7

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    The patient mental health care in PAH treatment.

  • ウプトラビ発売記念講演会in 九州・沖縄

    Role(s): Lecturer

    福岡  2017.7

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    当院におけるセレキシパグ使用症例

  • 東信肺校閲圧症フォーラム

    Role(s): Lecturer

    長野  2017.7

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    肺高血圧症の診断と治療~病診連携の実際~.

  • 肺高血圧症におけるNO-sGC-cGMP経路について考える会

    Role(s): Lecturer

    久留米市  2017.6

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    肺疾患合併PAHからみるリオシグアトの効果.

  • 平成29年度指宿内科医会学術講演会

    Role(s): Lecturer

    指宿市  2017.5

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    肺高血圧症のトータルケア.

  • 肺高血圧症治療管理研究会

    Role(s): Lecturer

    福岡  2017.1

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    トレプロスチニルの使用経験.

  • 臨床薬学研究会

    Role(s): Lecturer

    鹿児島市  2017.1

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    肺高血圧症の最近の治療と鹿児島での取り組み.

  • Meet The Specialist 2016肺高血圧症の早期発見・早期治療

    Role(s): Lecturer

    2016.11

  • 肺高血圧カンファレンスin 近見

    Role(s): Lecturer

    2016.10

  • 平成28年度 鹿児島県難病相談・支援センター医療相談

    Role(s): Lecturer

    2016.10

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    Audience: Guardians

  • 神奈川県肺高血圧症カンファレンス2016

    Role(s): Lecturer

    2016.10

  • エリキュース®症例検討カンファレンス

    Role(s): Lecturer

    2016.9

  • 曽於医師会学術講演会

    Role(s): Lecturer

    2016.9

  • 第6回 鹿児島周術期管理研究会

    Role(s): Lecturer

    2016.8

  • エポアクトフォーラム2015

    Role(s): Lecturer

    2015.9

  • 延岡医学会学術講演会

    Role(s): Lecturer

    2015.8

  • 熊本肺高血圧症治療を考える会

    Role(s): Lecturer

    2015.2

  • 第5回大分肺高血圧症研究会

    Role(s): Lecturer

    2015.2

  • 症例から学ぶ肺高血圧症in北九州

    Role(s): Lecturer

    2015.2

  • 香川 膠原病と肺高血圧症を考える会

    Role(s): Lecturer

    2015.2

  • 第12回九州肺高血圧症ワークショップ

    Role(s): Lecturer

    2015.1

  • リウマチ膠原病治療の未来を考える内科医師の会

    2013.11

  • 強皮症性肺高血圧症研究会

    2013.2

  • 産業医科大学大学院講義

    2013.2

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Media Coverage

  • 肺高血圧症~医療連携強化で病気の進行を防ぐ Newspaper, magazine

    朝日新聞  2022.7