Faculty Profiles - OHISHI Mitsuru

Papers - OHISHI Mitsuru

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窪薗琢郎, 大石充 . 【難治性高血圧Up-to-date 2021-診療と最新治療】難治性高血圧と心肥大・心房細動・心不全 . カレントテラピー39 ( 12 ) 1136 - 1140 2021.12

Language：Japanese Publisher：(株)ライフメディコム

高血圧は、圧負荷の増大により心肥大や心筋間質の線維化といった心筋リモデリングをきたし、冠動脈内皮障害を引き起こす。左室内圧の上昇に伴い左房圧も上昇し、心房拡大につながり心房細動の発症リスクとなる。また、糖尿病や脂質異常症、肥満といった生活習慣病も加わると、虚血性心疾患のリスクにもなる。最終的に、高血圧により引き起こされた心肥大や心房細動、虚血性心疾患などにより、心不全の発症につながる。早期の治療介入により、それらの発症を抑制できることが報告されているが、多剤併用にもかかわらず降圧目標値に到達できない治療抵抗性高血圧の患者が存在する。治療抵抗性高血圧患者は、コントロールされた高血圧患者と比較し、持続的な高血圧に伴う臓器障害をきたす可能性が高い。近年、ミネラルコルチコイド受容体(MR)拮抗薬や腎交感神経デナベーションの有用性が報告され、適切な降圧薬の選択や腎交感神経デナベーションによる適切な血圧コントロールにより臓器合併症の予防や進展抑制が期待できる。(著者抄録)

Ryo Arikawa, Daisuke Kanda, Yoshiyuki Ikeda, Akihiro Tokushige, Takeshi Sonoda, Kazuhiro Anzaki, Mitsuru Ohishi . Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage. . BMC cardiovascular disorders21 ( 1 ) 479 - 479 2021.12Reviewed International journal

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Stable coronary artery disease (CAD) patients with myocardial damage have a poor prognosis compared to those without myocardial damage. Recently, malnutrition has been reported to affect the prognosis of cardiovascular diseases. However, the effects of malnutrition on prognosis of CAD patients with myocardial damage remains uncertain. We investigated the effects of malnutrition on prognosis of CAD patients with myocardial damage who received percutaneous coronary intervention (PCI). METHODS: Subjects comprised 241 stable CAD patients with myocardial damage due to myocardial ischemia or infraction. Patients underwent successful revascularization for the culprit lesion by PCI using second-generation drug-eluting stents and intravascular ultrasound. The geriatric nutritional risk index (GNRI), which is widely used as a simple method for screening nutritional status using body mass index and serum albumin, was used to assess nutritional status. Associations between major cardiovascular and cerebrovascular events (MACCE) and patient characteristics were assessed. RESULTS: Mean GNRI was 100 ± 13, and there were 55 malnourished patients (23%; GNRI < 92) and 186 non-malnourished patients (77%). MACCE occurred within 3 years after PCI in 42 cases (17%), including 34 deaths (14%), and the malnourished group showed a higher rate of MACCE (38%) compared with the non-malnourished group (11%, p < 0.001). Univariate Cox proportional hazards analyses showed that MACCE was associated with age [hazard ratio (HR), 1.04; 95% confidence interval (CI), 1.04-1.07; p = 0.004], prior heart failure (HR 2.35; 95% CI 1.10-5.01; p = 0.027), high-sensitivity C-reactive protein (HR 1.08; 95% CI 1.03-1.11; p < 0.001), hemodialysis (HR 2.63; 95% CI 1.51-4.58; p < 0.001) and malnutrition (HR 3.69; 95% CI 2.11-6.42; p < 0.001). Multivariate Cox proportional hazards analysis revealed hemodialysis (HR 2.17; 95% CI 1.19-3.93; p = 0.011) and malnutrition (HR 2.30; 95% CI 1.13-4.67; p = 0.020) as significantly associated with MACCE. Furthermore, Cox proportional hazards models using malnutrition and hemodialysis revealed that patients with malnutrition and hemodialysis were at greater risk of MACCE after PCI than patients with neither malnutrition nor hemodialysis (HR 6.91; 95% CI 3.29-14.54; p < 0.001). CONCLUSIONS: In CAD patients with myocardial damage, malnutrition (GNRI < 92) represents an independent risk factor for MACCE. Assessment of nutritional status may help stratify the risk of cardiovascular events and encourage improvements in nutritional status.

DOI： 10.1186/s12872-021-02296-9

Scopus

PubMed

Kanda D., Takumi T., Sonoda T., Arikawa R., Anzaki K., Sasaki Y., Ohishi M. . Coronary artery perforation secondary to lifesaving pericardiocentesis for cardiac tamponade: a case report . BMC Cardiovasc Disord21 ( 1 ) 55 2021.12

Ninomiya Yuichi, Kawasoe Shin, Kubozono Takuro, Tokushige Akihiro, Ichiki Hitoshi, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . 一般日本人集団における腹部肥満と新規発症心房細動との男女別にみた関係性(Sex-specific relationship between abdominal obesity and new-onset atrial fibrillation in the general Japanese population) . Heart and Vessels36 ( 12 ) 1879 - 1884 2021.12

Language：Japanese Publisher：シュプリンガー・ジャパン(株)

2008年4月～2016年3月の間に健康診断を2回以上受診した参加者67379名(男性49.8%、平均54.3±10.0歳)を対象に、腹部肥満と新規発症心房細動(AF)との関係を後ろ向きに検討した。参加者の腹囲に基づいて過大腹囲群と正常腹囲群に分けた。全体および男女別に腹部肥満と新規発症心房細動との関連の強度を判定した。過大腹囲群は男性16329名、女性6539名であった。経過観察期間中央値は5年で、280例で新規発症AFが記録された。単変量解析では過大腹囲は男性では新規発症AFと有意に関連したが、女性では関連しなかった。多変量解析では男性で過大腹囲が新規発症AFと有意に関連したが、女性では関連しなかった。腹部肥満は男性では新規発症AFのリスクの増加と関連していた。

Language：Japanese Publisher：(株)ライフメディコム

Salim Anwar A, Kawasoe S, Kubozono T, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M. . Assessment of future hypertension risk by sex using combined body mass index and waist-to-height ratio. . Circ Rep4 ( 1 ) 9 - 16 2021.11Reviewed

Uchikado Y, Ikeda Y, Sasaki Y, Iwabayashi M, Akasaki Y, Ohishi M. . Association of lectin-like oxidized low-density lipoprotein receptor-1 with angiotensin II type 1 receptor impacts mitochondrial quality control, offering promise for the treatment of vascular senescence. . Front Cardiovasc Med8 788655 2021.11Reviewed

Language：English Publisher：Frontiers in Cardiovascular Medicine

Lectin-like oxidized low-density lipoprotein (ox-LDL) causes vascular senescence and atherosclerosis. It has been reported that ox-LDL scavenger receptor-1 (LOX-1) is associated with the angiotensin II type 1 receptor (AT1R). While mitochondria play a crucial role in the development of vascular senescence and atherosclerosis, they also undergo quality control through mitochondrial dynamics and autophagy. The aim of this study was to investigate (1) whether LOX-1 associates with AT1R, (2) if this regulates mitochondrial quality control, and (3) whether AT1R inhibition using Candesartan might ameliorate ox-LDL-induced vascular senescence. We performed in vitro and in vivo experiments using vascular smooth muscle cells (VSMCs), and C57BL/6 and apolipoprotein E-deficient (ApoE KO) mice. Administration of oxidized low-density lipoprotein (ox-LDL) to VSMCs induced mitochondrial dysfunction and cellular senescence accompanied by excessive mitochondrial fission, due to the activation of fission factor Drp1, which was derived from the activation of the Raf/MEK/ERK pathway. Administration of either Drp1 inhibitor, mdivi-1, or AT1R blocker candesartan attenuated these alterations. Electron microscopy and immunohistochemistry of the co-localization of LAMP2 with TOMM20 signal showed that AT1R inhibition also increased mitochondrial autophagy, but this was not affected by Atg7 deficiency. Conversely, AT1R inhibition increased the co-localization of LAMP2 with Rab9 signal. Moreover, AT1R inhibition-induced mitochondrial autophagy was abolished by Rab9 deficiency, suggesting that AT1R signaling modulated mitochondrial autophagy derived from Rab9-dependent alternative autophagy. Inhibition of the Raf/MEK/ERK pathway also decreased the excessive mitochondrial fission, and Rab9-dependent mitochondrial autophagy, suggesting that AT1R signaling followed the Raf/MEK/ERK axis modulated both mitochondrial dynamics and autophagy. The degree of mitochondrial dysfunction, reactive oxygen species production, vascular senescence, atherosclerosis, and the number of fragmented mitochondria accompanied by Drp1 activation were all higher in ApoE KO mice than in C57BL/6 mice. These detrimental alterations were successfully restored, and mitochondrial autophagy was upregulated with the administration of candesartan to ApoE KO mice. The association of LOX-1 with AT1R was found to play a crucial role in regulating mitochondrial quality control, as cellular/vascular senescence is induced by ox-LDL, and AT1R inhibition improves the adverse effects of ox-LDL.

DOI： 10.3389/fcvm.2021.788655

Scopus

PubMed

Issei Yoshimoto, Naoya Oketani, Masakazu Ogawa, Shunichi Imamura, Kenta Omure, Hideto Chaen, Masaaki Miyata, Shuichi Hamasaki, Goichi Yotsumoto, Mitsuru Ohishi . Percutaneous Extraction for Misplacement of Pacemaker Leads Within the Coronary Artery and Left Ventricle . JACC: Case Reports3 ( 16 ) 1746 - 1752 2021.11

内門義博, 池田義之, 大石充 . 【糖尿病と循環器疾患update】糖尿病と血管合併症update . 循環器内科90 ( 5 ) 508 - 511 2021.11

Arikawa R, Kanda D, Ikeda Y, Tokushige A, Sonoda T, Anzaki K, Ohishi M . Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage. . BMC Cardiovasc Disord21 ( 1 ) 479 - 479 2021.10Reviewed

牧迫飛雄馬, 窪薗琢郎, 大石充 . 【日本における高齢者コホート研究の成果と現状】垂水研究 . 老年内科4 ( 4 ) 405 - 409 2021.10

赤崎雄一, 大石充 . 【生活習慣病】生活習慣病の予防と治療　高血圧 . 臨牀と研究98 ( 10 ) 1166 - 1171 2021.10

Ninomiya Y, Inoue K, Tanaka N, Okada M, Tanaka K, Onishi T, Hirao Y, Oka T, Inoue H, Takayasu K, Nakamaru R, Kitagaki R, Koyama Y, Okamura A, Iwakura K, Ohishi M, Fujii K. . Absence of first-pass isolation is associated with poor pulmonary vein isolation durability and atrial fibrillation ablation outcomes . J Arrhythm37 ( 6 ) 1468 - 1476 2021.9Reviewed

川畑孟子, 山口聡, 小島聡子, 川添晋, 窪薗琢郎, 池田義之, 大石充 . アセトアミノフェンが原因と考えられた急性好酸球性心筋炎の再発を来した一例 . 日本心臓病学会学術集会抄録69回 O - 083 2021.9

濱元裕喜, 堀添善尚, 安田久代, 湯淺敏典, 大石充 . Valsalva洞仮性動脈瘤を合併したStreptococcus dysagalactiaeによる感染性心内膜炎の1例 . 日本心臓病学会学術集会抄録69回 O - 263 2021.9

Kawasoe Shin, Kubozono Takuro, Ojima Satoko, Kawabata Takeko, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . 血清尿酸値と血圧異常の有病率とに認められたJ字型曲線の関連(J-shaped curve for the association between serum uric acid levels and the prevalence of blood pressure abnormalities) . Hypertension Research44 ( 9 ) 1186 - 1193 2021.9

Language：English Publisher：Nature Publishing Group

血清尿酸値と血圧異常との関連について検討するため、2001～2015年に厚生連病院で定期健康診断を受けた者のデータを解析した。血清尿酸値(mg/dL)が2.0以下の者を低尿酸血症群(LUA群)とし、それ以外の者を血清尿酸値の四分位毎に4群に分けた(SUA1群:2.1～4.0、SUA2群:4.1～5.0、SUA3群:5.1～6.0、SUA4群:6.1以上)。各群の高血圧(130/80mmHg以上または降圧薬の使用)および高血圧症(140/90mmHg以上または降圧薬の使用)の有病率を算出し、血圧異常の割合が最も低い群と比較した各群の調整オッズ比を求めた。定期健康診断を受けた236221名(男性107146名、平均56.0±15.0歳)のデータを解析した。高血圧の有病率は、LUA群、SUA1群～SUA4群でそれぞれ49.0、44.6、52.3、58.6、65.3%であり、高血圧症の有病率はそれぞれ31.0、27.4、33.5、38.7、43.8%であった。SUA1群と比較して、LUA群およびSUA2群～SUA4群の高血圧と高血圧症のオッズ比は有意に高かった。本研究にて、血清尿酸値は血圧異常の有病率と有意に関連し、その関連はJ字型曲線であることが示された。

大牟禮健太, 神田大輔, 安崎和博, 有川亮, 池田義之, 大石充 . 浅大腿動脈の慢性完全閉塞病変にステント留置後、巨大仮性動脈瘤を形成した一例 . 日本心臓病学会学術集会抄録69回 O - 185 2021.9

東祐大, 小瀬戸一平, 末永智大, 有村俊博, 大石充 . 気管支喘息を合併した難治性多枝冠攣縮性狭心症の1例 . 日本心臓病学会学術集会抄録69回 O - 105 2021.9

神田大輔, 佐々木雄一, 有川亮, 安崎和博, 大牟禮健太, 大石充 . 心タンポナーデに対する心嚢穿刺後の二次的冠動脈穿孔に対してコイル塞栓による止血を行った一例 . 日本心臓病学会学術集会抄録69回 O - 360 2021.9

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Papers - OHISHI Mitsuru