Updated on 2022/08/06

写真a

 
GOTO Tetsuya
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Neurology Professor
Title
Professor

Degree

  • 博士（歯学） ( 1992.3   九州大学 )

Research Interests

  • アルツハイマー病

  • 三叉神経節

  • 歯根膜細胞

  • 口腔インプラント

  • 神経ペプチド

  • 骨代謝

  • Bone Metabolism

  • Alzheimer's Disease

  • Implant

  • trigeminal ganglion

  • Dementia

  • 骨代謝

Research Areas

  • Life Science / Oral biological science

  • Life Science / Anatomy and histopathology of nervous system

  • Life Science / Regenerative dentistry and dental engineering

  • Life Science / Basic brain sciences

  • Life Science / Oral biological science

  • Life Science / Oral biological science

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Education

  • Kyushu University

    - 1992.3

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    Country： Japan

  • 九州大学大学院   歯学研究科

    - 1992

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    Country： Japan

  • Kyushu University   Graduate School, Division of Dental Research

    - 1992

  • Kyushu University

    - 1988.3

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    Country： Japan

  • Kyushu University   School of Dentistry

    - 1988

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    Country： Japan

  • Kyushu University   Faculty of Dentistry

    - 1988

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Research History

  • Kagoshima University   Professor

    2014.4

  • Kagoshima University   Professor

    2014.4

  • - Kyushu Dental College, Associate Professor

    2001

Professional Memberships

  • 日本認知症学会

    2019.4

  • American Society for Bone and Mineral Research

    2015.10

  • International Association for Dental Research

    2015.10

  • 日本組織細胞化学会

    2015.10

  • 日本口腔組織培養学会

    2015.10

  • 日本解剖学会

    2015.10

  • 歯科基礎医学会

    2015.10

  • 歯科基礎医学会

  • American Society for Bone and Mineral Research

  • American Society for Bone and Mineral Research

  • International Association for Dental Research

  • International association of Dental Research

  • Japanese Association for Oral Biology

  • The Japanese Association of Anatomists

  • The Japanese Society for Bone and Mineral Research

  • 日本分子生物学会

  • Japanese Society of Oral Implantology

  • 日本口腔組織培養学会

  • THE JAPANESE SOCIETY OF PEDIATRIC DENTISTRY

  • 日本組織細胞化学会

  • JAPANESE SOCIETY OF GERODONTOLOGY

  • 日本解剖学会

  • JAPAN SOCIETY FOR DEMENTIA RESEARCH

  • 日本骨代謝学会

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Committee Memberships

  • 日本口腔組織培養学会   理事・編集委員  

    2006   

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    Committee type：Academic society

    日本口腔組織培養学会

  • 日本組織細胞化学会   評議員・編集委員  

    2003   

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    Committee type：Academic society

    日本組織細胞化学会

  • 歯科基礎医学会   評議員  

    2001   

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    Committee type：Academic society

    歯科基礎医学会

Studying abroad experiences

  • 1994.10 - 1996.3   トロント大学   ポストドクトラルフェロー

  • 1992.10 - 1994.9   ブリティッシュ・コロンビア大学   ポストドクトラルフェロー

Qualification acquired

  • Dentist

 

Papers

  • Eriko Kuramoto, Yasuhiro R. Tanaka, Hiroyuki Hioki, Tetsuya Goto, Takeshi Kaneko .  Local Connections of Pyramidal Neurons to Parvalbumin-Producing Interneurons in Motor-Associated Cortical Areas of Mice .  eneuro9 ( 1 ) ENEURO.0567 - 20.2021   2022.1

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Society for Neuroscience  

    DOI： 10.1523/eneuro.0567-20.2021

    Scopus

    PubMed

  • Wang R.P.H. .  IL-1 beta and TNF-alpha play an essential role in modulating the risk of both periodontitis and Alzheimer's disease .  Alzheimer's & dementia : the journal of the Alzheimer's Association17   2021.12

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    Language：Japanese   Publisher：Alzheimer's & dementia : the journal of the Alzheimer's Association  

    DOI： 10.1002/alz.058464

    Scopus

  • Iwai H. .  Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury .  Journal of Neuroinflammation18 ( 1 ) 227   2021.12

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    Language：Japanese   Publisher：Journal of Neuroinflammation  

    DOI： 10.1186/s12974-021-02283-z

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  • Ferdous Taslima, Cha-Gyun Jung, Chunyu Zhou, Mona Abdelhamid, Mohammad Abdullah, Tetsuya Goto, Takashi Saito, Takaomi C. Saido, Makoto Michikawa .  Tooth Loss Induces Memory Impairment and Gliosis in App Knock-In Mouse Models of Alzheimer's Disease .  JOURNAL OF ALZHEIMERS DISEASE80 ( 4 ) 1687 - 1704   2021

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：IOS PRESS  

    Background: Epidemiological studies have shown that tooth loss is associated with Alzheimer's disease (AD) and dementia. However, the molecular and cellular mechanisms by which tooth loss causes AD remain unclear.Objective: We investigated the effects of tooth loss on memory impairment and AD pathogenesis in App(NL-G-F) mice.Methods: Maxillary molar teeth on both sides were extracted from 2-month-old App(NL-G-F) mice, and the mice were reared for 2 months. The short- and long-term memory functions were evaluated using a novel object recognition test and a passive avoidance test. Amyloid plaques, amyloid-beta (A beta) levels, glial activity, and neuronal activity were evaluated by immunohistochemistry, A beta ELISA, immunofluorescence staining, and western blotting. The mRNA expression levels of neuroinflammatory cytokines were determined by qRT-PCR analysis.Results: Tooth loss induced memory impairment via an amyloid-cascade-independent pathway, and decreased the neuronal activity, presynaptic and postsynaptic protein levels in both the cortex and hippocampus. Interestingly, we found that tooth loss induced glial activation, which in turn leads to the upregulation of the mRNA expression levels of the neuroinflammation cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1 beta in the hippocampus. We also found that tooth loss activated a stress-activated protein kinase, c-Jun N-terminal kinase (JNK), and increased heat shock protein 90 (HSP90) levels in the hippocampus, which may lead to a glial activation.Conclusion: Our findings suggest that taking care of teeth is very important to preserve a healthy oral environment, which may reduce the risk of cognitive dysfunction.

    DOI： 10.3233/JAD-201055

    Web of Science

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  • Dhar Ashis, Kuramoto Eriko, Fukushima Makoto, Iwai Haruki, Yamanaka Atsushi, Goto Tetsuya .  The Periodontium Damage Induces Neuronal Cell Death in the Trigeminal Mesencephalic Nucleus and Neurodegeneration in the Trigeminal Motor Nucleus in C57BL/6J Mice .  Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ54 ( 1 ) 11 - 19   2021

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    Publisher：日本組織細胞化学会  

    <p>Proprioception from masticatory apparatus and periodontal ligaments comes through the trigeminal mesencephalic nucleus (Vmes). We evaluated the effects of tooth loss on neurodegeneration of the Vmes and trigeminal motor nucleus (Vmo). Bilateral maxillary molars of 2-month-old C57BL/6J mice were extracted under anesthesia. Neural projections of the Vmes to the periodontium were confirmed by injecting Fluoro-Gold (FG) retrogradely into the extraction sockets, and for the anterograde labeling adeno-associated virus encoding green fluorescent protein (AAV-GFP) was applied. For immunohistochemistry, Piezo2, ATF3, Caspase 3, ChAT and TDP-43 antibodies were used. At 1 month after tooth extraction, the number of Piezo2-immunoreactive (IR) Vmes neurons were decreased significantly. ATF3-IR neurons were detected on day 5 after tooth extraction. Dead cleaved caspase-3-IR neurons were found among Vmes neurons on days 7 and 12. In the Vmo, neuronal cytoplasmic inclusions (NCIs) formation type of TDP-43 increased at 1 and 2 months after extraction. These indicate the existence of neural projections from the Vmes to the periodontium in mice and that tooth loss induces the death of Vmes neurons followed by TDP-43 pathology in the Vmo. Therefore, tooth loss induces Vmes neuronal cell death, causing Vmo neuro­degeneration and presumably affecting masticatory function.</p>

    DOI： 10.1267/ahc.20-00036

    PubMed

  • Goto T, Kuramoto E, Dhar A, Wang RP-H, Seki H, Iwai H, Yamanaka A, Matsumoto S, Hara H, Michikawa M, Ohyagi Y, Leung WK, Chang RCC. .  Neurodegeneration of trigeminal mesencephalic neurons by the tooth loss triggers the progression of Alzheimer's disease in 3зTg-AD model mice. .  Journal of Alzheimer's Disease76 ( 4 ) 1443 - 1459   2020.8Neurodegeneration of trigeminal mesencephalic neurons by the tooth loss triggers the progression of Alzheimer's disease in 3зTg-AD model mice.Reviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  • Tetsuya Goto, Eriko Kuramoto, Ashis Dhar, Rachel Pei Hsuan Wang, Haruka Seki, Haruki Iwai, Atsushi Yamanaka, Shin Ei Matsumoto, Hiromitsu Hara, Makoto Michikawa, Yasumasa Ohyagi, Wai Keung Leung, Raymond Chuen Chung Chang .  Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3×Tg-AD Model Mice .  Journal of Alzheimer's Disease76 ( 4 ) 1443 - 1459   2020

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    The mesencephalic trigeminal nucleus (Vmes) is not only anatomically adjacent to the locus coeruleus (LC) but is also tightly associated with the function of the LC. The LC can be the first area in which Alzheimer's disease (AD) develops, although it is unclear how LC neuronal loss occurs. Objective: We investigated whether neuronal death in the Vmes can be spread to adjacent LC in female triple transgenic (3×Tg)-AD mice, how amyloid-ß (Aß) is involved in LC neuronal loss, and how this neurodegeneration affects cognitive function. Methods: The molars of 3×Tg-AD mice were extracted, and the mice were reared for one week to 4 months. Immunohistochemical analysis, and spatial learning/memory assessment using the Barnes maze were carried out. Results: In 4-month-old 3×Tg-AD mice, aggregated cytotoxic Aß42 was found in granules in Vmes neurons. Neuronal death in the Vmes occurred after tooth extraction, resulting in the release of cytotoxic Aß42 and an increase in CD86 immunoreactive microglia. Released Aß42 damaged the LC, in turn inducing a significant reduction in hippocampal neurons in the CA1 and CA3 regions receiving projections from the LC. Based on spatial learning/memory assessment, after the tooth extraction in the 4-month-old 3×Tg-AD mice, increased latency was observed in 5-month-old 3×Tg-AD mice 1 month after tooth extraction, which is similar increase of latency observed in control 8-month-old 3×Tg-AD mice. Measures of cognitive deficits suggested an earlier shift to dementia-like behavior after tooth extraction. Conclusion: These findings suggest that tooth extraction in the predementia stage can trigger the spread of neurodegeneration from the Vmes, LC, and hippocampus and accelerate the onset of dementia.

    DOI： 10.3233/JAD-200257

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  • 後藤 哲哉, 倉本 恵梨子, Ashis Dhar, 松本 信英, 原 博満, 山中 淳之, 岩井 治樹, 大八木 保政, 道川 誠 .  歯の喪失はpre-dementiaからdementiaへの進行を早める .  Dementia Japan33 ( 4 ) 550 - 550   2019.10歯の喪失はpre-dementiaからdementiaへの進行を早める

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    Language：Japanese   Publisher：(一社)日本認知症学会  

  • Tetsuya Goto, W. Keung Leung .  Tooth Loss and Alzheimer’s Disease .  Current Oral Health Reports6 ( 2 ) 82 - 88   2019.6

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    Purpose of Review: Alzheimer’s disease (AD) is a major subtype of dementia. Recent cohort studies have demonstrated that loss of masticatory function, periodontitis, and/or tooth loss are risk factors for AD. The present review provides an overview of the existing literature as well as recent evidence regarding the relationship between tooth loss and the onset of AD. Recent Findings: In the dental field, tooth loss is one of the most relevant factors related to the prevalence of AD. This is important in a progressively elderly population because tooth loss is associated with the risk of mild cognitive impairment (MCI) developing into dementia due to a cascade of neurodegeneration caused by damage to periodontal tissues via the trigeminal nerve, locus coeruleus (LC), and hippocampus. Additionally, periodontal disease and/or the loss of masticatory function are likely to exacerbate factors associated with AD. Summary: Tooth loss in the elderly may cause neurodegeneration and act as a trigger for the progression from MCI to dementia. Moreover, neurodegeneration due to tooth loss is thought to exacerbate the accumulation of AD-specific amyloid-β and phosphorylated tau proteins, which worsen the pathological condition of AD. Although further evidence is needed, novel strategies for avoiding the progression to AD due to tooth loss in the elderly are required.

    DOI： 10.1007/s40496-019-0219-1

    Scopus

  • 後藤 哲哉 .  三叉神経節における神経ー免疫系システム .  別冊Bio Clinicaー   2019三叉神経節における神経ー免疫系システムReviewed

  • Wakoto Matsuda, Takahiro Sonomura, Satoru Honma, Sachi Ohno, Tetsuya Goto, Shuichi Hirai, Masahiro Itoh, Yoshiko Honda, Hiroki Fujieda, Jun Udagawa, Shingo Takano, Fumino Fujiyama, Shuichi Ueda .  Anatomical variations of the torcular Herophili: macroscopic study and clinical aspects .  Anatomical Science International93 ( 4 ) 464 - 468   2018.9Anatomical variations of the torcular Herophili: macroscopic study and clinical aspects

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    Publisher：Springer Tokyo  

    The anatomical variations of the confluence of sinuses were examined, focusing on the continuity of the superior sagittal sinus (SSS) and the transverse sinuses (TSs). In the 142 specimens studied, there were 72 symmetric cases (50.7%) and 70 asymmetric cases (49.3%). The symmetric group (no dominant type) was categorized into 34 cases of bifurcation (23.9%) and 38 cases of confluence (26.8%). The asymmetric group was categorized into 54 cases of the right-dominant type (38.0%) and 16 cases of the left-dominant type (11.3%). The right-dominant type was further categorized into 38 partially-communicating (26.8%) and 16 non-communicating types (11.3%). The left-dominant type was categorized into 11 partially-communicating (7.7%) and 5 non-communicating types (3.5%). In summary, the SSS asymmetrically drained into one TS in about half of the cases studied. The right-dominant type was about three to four times as common as the left-dominant type. The draining pattern shown by the asymmetric group could provoke intracranial hypertension due to unilateral jugular vein obstruction. In order to avoid this risk in cases of neck dissection, jugular vein catheterization, or hypercoagulopathy, preoperative evaluations of the dural sinus variations via MR venography, three-dimensional CT, or plain X-ray of the skull are recommended.

    DOI： 10.1007/s12565-018-0436-z

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    PubMed

  • Matsuda W. .  Anatomical variations of the torcular Herophili: macroscopic study and clinical aspects .  Anatomical Science International93 ( 4 ) 464 - 468   2018.9

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    Publisher：Anatomical Science International  

    DOI： 10.1007/s12565-018-0436-z

    Scopus

  • 八木 孝和, 倉本 恵梨子, 関 遥, 齋藤 充, 岩井 治樹, 山中 淳之, 後藤 哲哉 .  アルツハイマー病モデルマウスにおける三叉神経系の神経変性が咀嚼機能に与える影響 .  Journal of Oral Biosciences Supplement2018   392 - 392   2018.9アルツハイマー病モデルマウスにおける三叉神経系の神経変性が咀嚼機能に与える影響

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    Publisher：(一社)歯科基礎医学会  

  • Matsuda W, Sonomura T, Honma S, Ohno S, Goto T, Hirai S, Itoh M, Honda Y, Fujieda H, Udagawa J, Takano S, Fujiyama F, Ueda S .  Anatomical variations of the torcular Herophili: macroscopic study and clinical aspects. .  Anatomical science international93 ( 4 ) 464 - 468   2018.9Anatomical variations of the torcular Herophili: macroscopic study and clinical aspects.

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  • Wakoto Matsuda, Takahiro Sonomura, Satoru Honma, Sachi Ohno, Tetsuya Goto, Shuichi Hirai, Masahiro Itoh, Yoshiko Honda, Hiroki Fujieda, Jun Udagawa, Shuichi Ueda .  Anatomical variations of the recurrent artery of Heubner: number, origin, and course .  Anatomical Science International93 ( 3 ) 317 - 322   2018.6

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    Publisher：Springer Tokyo  

    The clinical anatomy of the recurrent artery of Heubner (RAH) was examined, focusing on its number, origin, and course, in a large number of brain specimens. We studied 724 RAH in total from 357 brain specimens (714 hemispheres). In 98.74 % of 714 cases there were one or more RAHs, while it was absent in 1.26 % of cases. There was a single RAH in 96.22 % of cases, double in 2.38 % of cases, and triple in 0.14 % of cases. In this study, three origin types of the RAH were defined. We defined A1 and A2 segment of the anterior cerebral artery (ACA) as the artery from the origin of the ACA to the junction of the anterior communicating artery (AComA) and the artery from the junction of the AComA to the anterior border of the corpus callosum, respectively. In 76.2 % of 724 arteries, the RAH originated from the junction of the A1 and A2 segment of the ACA. In 16.3 %, the RAH originated from the A2 segment of the ACA. In 7.5 %, the RAH originated from the A1 segment of the ACA. The course of the RAH was superior to the A1 segment of the ACA in 30.1 % of 724 arteries, anterior in 62.2 %, and posterior in 7.7 %. It is of great importance for neurosurgeons to understand the detailed anatomical variations of the RAH before operating to prevent operative complications resulting in neurological deficits.

    DOI： 10.1007/s12565-017-0415-9

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    PubMed

  • Matsuda Wakoto, Sonomura Takahiro, Honma Satoru, Ohno Sachi, Goto Tetsuya, Hirai Shuichi, Itoh Masahiro, Honda Yoshiko, Fujieda Hiroki, Udagawa Jun, Ueda Shuichi .  Heubner反回動脈の解剖学的変異　数、起始および走行について(Anatomical variations of the recurrent artery of Heubner: number, origin, and course) .  Anatomical Science International93 ( 3 ) 317 - 322   2018.6Heubner反回動脈の解剖学的変異　数、起始および走行について(Anatomical variations of the recurrent artery of Heubner: number, origin, and course)

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    Publisher：シュプリンガー・ジャパン(株)  

    脳標本357個(半脳714個)に対し、Heubner反回動脈(RAH)(計724)の臨床解剖学的検討を行い、なかでも、RAHの数、起始、走行の変異について調査した。その結果、RAHの数は、半脳の1.26%で0個、96.22%で1個、2.38%で2個、0.14%で3個で、RAH起始部の外径は、0.69±0.25mmで、外径範囲は0.32〜1.11mmであった。なお、RAHの76.2%は前大脳動脈のA1区とA2区間から始まり、16.3%はA2区から、7.5%はA1区から起始し、RAHの走行では、前大脳動脈のA1区に対して30.1%が上方、62.2%が前方、7.7%が後方であった。なお、異常例は3例認められ、1例目はRAHが副中大脳動脈から分枝し、起始部から遠位で2本のRAHに分かれていた。2例目はRAHが眼窩前頭動脈と共通の幹から起始しており、3例目はRAHが眼窩前頭動脈および前頭極動脈と共通の幹から起始していた。

  • Matsuda, Wakoto, Sonomura, Takahiro, Honma, Satoru, Ohno, Sachi, Goto, Tetsuya, Hirai, Shuichi, Itoh, Masahiro, Honda, Yoshiko, Fujieda, Hiroki, Udagawa, Jun, Takano, Shingo, Fujiyama, Fumino, Ueda, Shuichi .  Anatomical variations of the torcular Herophili: macroscopic study and clinical aspects .  Anatomical science international93 ( 4 ) 464 - 468   2018.3Anatomical variations of the torcular Herophili: macroscopic study and clinical aspects

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    Publisher：SPRINGER  

    The anatomical variations of the confluence of sinuses were examined, focusing on the continuity of the superior sagittal sinus (SSS) and the transverse sinuses (TSs). In the 142 specimens studied, there were 72 symmetric cases (50.7%) and 70 asymmetric cases (49.3%). The symmetric group (no dominant type) was categorized into 34 cases of bifurcation (23.9%) and 38 cases of confluence (26.8%). The asymmetric group was categorized into 54 cases of the right-dominant type (38.0%) and 16 cases of the left-dominant type (11.3%). The right-dominant type was further categorized into 38 partially-communicating (26.8%) and 16 non-communicating types (11.3%). The left-dominant type was categorized into 11 partially-communicating (7.7%) and 5 non-communicating types (3.5%). In summary, the SSS asymmetrically drained into one TS in about half of the cases studied. The right-dominant type was about three to four times as common as the left-dominant type. The draining pattern shown by the asymmetric group could provoke intracranial hypertension due to unilateral jugular vein obstruction. In order to avoid this risk in cases of neck dissection, jugular vein catheterization, or hypercoagulopathy,

    DOI： 10.1007/s12565-018-0436-z

  • Koshio Yasuhiro, Nagayama Kazuaki, Goto Tetsuya, Ozeki Kazuhide .  Preparation of Si-containing calcium phosphate thin film and evaluation of cell adhesion .  Journal of Bio-Integration8 ( 1 ) 123 - 126   2018

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    Publisher：Bio Integration Society  

    Ti implants have been used primarily for current dental implants．However the peri-implant inflammation is a seriousploblem．In order to improve the adhesion between the abutment and the epithelium，Si-containing calciumphosphate thin film containing Si-Ca-P was coated on Ti using sputtering method from a mixture of hydroxyapatiteand SiO2 as a target．Then，cell adhesion on the thin film was evaluated．Mouse embryo derived fibroblasts(NIH-3T3) were seeded on Si-containing calcium phosphate thin films．After 48 hours of cell seeding, fluorescenceimage of cells and the number of attached cells were observed using a microscope．As a result，the number of attached cells on the Si- containing calcium phosphate thin films increased withincreasing Si content，and reached a maximum of 46 (cells/frame) on the film with 30% of SiO2 /SiO2 +HAtarget．Then the number of attached cells decreased to 24 (cells/frame) with the film with 100% of SiO2 target．

    DOI： 10.32176/biointeg.8.1_123

  • Eriko Kuramoto, Haruki Iwai, Atsushi Yamanaka, Sachi Ohno, Haruka Seki, Yasuhiro R. Tanaka, Takahiro Furuta, Hiroyuki Hioki, Tetsuya Goto .  Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectors .  Journal of Comparative Neurology525 ( 18 ) 3821 - 3839   2017.12

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    Publisher：WILEY  

    The rodent orbitofrontal cortex is involved in a variety of cognitive and behavioral functions that require thalamic input to be successfully expressed. Although the thalamic nucleus submedius (Sm) is a major source of afferents to the orbitofrontal cortex, thalamocortical projection from the Sm has not been fully elucidated. In the present study, we first divided the rat Sm into dorsal and ventral parts according to the distribution of vesicular glutamate transporter 2-immunoreactive varicosities, which were somatosensory afferents from the brain stem. Subsequently we investigated dendritic and axonal arborizations of individual dorsal and ventral Sm neurons by visualizing the processes with Sindbis virus vectors expressing membrane-targeted fluorescent proteins. The number of dendritic processes of ventral Sm neurons was greater than that of dorsal Sm neurons. In the cerebral cortex, all the reconstructed Sm neurons sent axons primarily to layers 2–5. Interestingly, dorsal Sm neurons formed a single axon arbor exclusively within the ventrolateral orbital area, whereas ventral Sm neurons made two axon arbors in the lateral orbital and ventral orbital areas simultaneously. The spread of each axon arbor was 500–1000 µm in diameter in the direction tangential to the cortical surface. These results indicate that the dorsal and ventral Sm comprise two distinct thalamocortical pathways. The dorsal Sm pathway relay somatosensory information to the ventrolateral orbital area and may be involved in emotional and aversive aspects of nociceptive information processing, whereas the ventral Sm pathway seems to co-activate distant orbitofrontal cortical areas, and may link their functions under certain circumstances.

    DOI： 10.1002/cne.24306

    Web of Science

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  • 尾関 和秀, 後藤 哲哉, 青木 秀希 .  スパッタリング法を用いたPEEK上へのHA薄膜の作製と骨形成 .  Journal of Bio-Integration7 ( 1 ) 81 - 85   2017.12スパッタリング法を用いたPEEK上へのHA薄膜の作製と骨形成

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    Publisher：バイオインテグレーション学会  

    スパッタリング法によるTi中間層及びハイドロキシアパタイト(HA)薄膜の作製を試みた。審美性評価の観点から、透過性を確認するため、石英基板への成膜試料も作製した。成膜したHA薄膜は、120℃で24時間水熱処理を行い、結晶化させた。成膜後、膜の表面観察により、膜の剥離状態及び透明性を評価した。骨親和性の評価には、ラット頭頂骨由来初代培養系骨芽細胞を用い、骨形成実験を行った。Tiを中間層とすることで、polyetheretherketone(PEEK)基板上へのHA成膜が可能であることが示唆された。水熱処理の有無に関わらず、Ti中間層50nm以上では金属光沢があり、透明性は認めなかったが、Ti中間層10nm以下では、うっすらと灰色を認め、透明性は確保された。特に、Ti中間層5nmでは、石英板単体と比較しても高い透明性が確保されていた。骨形成面積は、Ti 100nm-HAとTi板HAが最も高くTi 100nm-HAについては、HA膜がPEEK板に付与されることで、従来のTi板HAに匹敵する骨親和性を示した。HAが付与されたTi 5nm-HAは、Ti 100nm-HAと比べて、有意に低値となった。

  • Tetsuya Goto, Haruki Iwai, Eriko Kuramoto, Atsushi Yamanaka .  Neuropeptides and ATP signaling in the trigeminal ganglion .  Japanese Dental Science Review53 ( 4 ) 117 - 124   2017.11

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    Publisher：Elsevier Ltd  

    Peripheral nociceptive stimuli from orofacial structures are largely transmitted by the trigeminal nerve. According to the peripheral noxious stimuli, neurons in the trigeminal ganglion (TG) produce neuropeptides such as substance P, and calcitonin-gene-related peptide, etc. Beside the production of neuropeptides, there exists unique non-synaptic interaction system between maxillary and mandibular neurons in the TG. Neurons in the TG are surrounded by satellite glial cells (SGCs), which initially receive the signal from TG neurons. These activated SGCs secrete a transmitter to activate adjacent SGCs or TG neurons, thereby amplifying the signal, for example, from mandibular neurons to maxillary neurons in the TG. Similar to the dorsal root ganglion, in the TG, microglia/macrophage-like cells (MLCs) are activated by uptake of a transmitter from TG neurons or SGCs. This communication between neurons, SGCs, and MLCs results in responses such as ectopic pain, hyperesthesia, or allodynia. The focus of this review is the cooperative interaction of the maxillary and mandibular nerves in the TG by neuropeptides, and adenosine 3′-phosphate (ATP) signaling from neurons to SGCs and MLCs. Stimulated neurons either secrete ATP by means of vesicular nucleotide transporters, or secrete neuropeptides from the neuronal cell body to mediate signal transmission.

    DOI： 10.1016/j.jdsr.2017.01.003

    Scopus

    PubMed

  • Kuramoto E, Iwai H, Yamanaka A, Ohno S, Seki H, Tanaka YR, Furuta T, Hioki H, Goto T .  Dorsal and Ventral Parts of Thalamic Nucleus Submedius Project to Different Areas of Rat Orbitofrontal Cortex: A Single Neuron-Tracing Study Using Virus Vectors. .  The Journal of comparative neurology   2017.8Dorsal and Ventral Parts of Thalamic Nucleus Submedius Project to Different Areas of Rat Orbitofrontal Cortex: A Single Neuron-Tracing Study Using Virus Vectors.

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  • Eriko Kuramoto, Shixiu Pan, Takahiro Furuta, Yasuhiro R. Tanaka, Haruki Iwai, Atsushi Yamanaka, Sachi Ohno, Takeshi Kaneko, Tetsuya Goto, Hiroyuki Hioki .  Individual mediodorsal thalamic neurons project to multiple areas of the rat prefrontal cortex: A single neuron-tracing study using virus vectors .  Journal of Comparative Neurology525 ( 1 ) 166 - 185   2017.1

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    Publisher：WILEY-BLACKWELL  

    The prefrontal cortex has an important role in a variety of cognitive and executive processes, and is generally defined by its reciprocal connections with the mediodorsal thalamic nucleus (MD). The rat MD is mainly subdivided into three segments, the medial (MDm), central (MDc), and lateral (MDl) divisions, on the basis of the cytoarchitecture and chemoarchitecture. The MD segments are known to topographically project to multiple prefrontal areas at the population level: the MDm mainly to the prelimbic, infralimbic, and agranular insular areas; the MDc to the orbital and agranular insular areas; and the MDl to the prelimbic and anterior cingulate areas. However, it is unknown whether individual MD neurons project to single or multiple prefrontal cortical areas. In the present study, we visualized individual MD neurons with Sindbis virus vectors, and reconstructed whole structures of MD neurons. While the main cortical projection targets of MDm, MDc, and MDl neurons were generally consistent with those of previous results, it was found that individual MD neurons sent their axon fibers to multiple prefrontal areas, and displayed various projection patterns in the target areas. Furthermore, the axons of single MD neurons were not homogeneously spread, but were rather distributed to form patchy axon arbors approximately 1 mm in diameter. The multiple-area projections and patchy axon arbors of single MD neurons might be able to coactivate cortical neuron groups in distant prefrontal areas simultaneously. Furthermore, considerable heterogeneity of the projection patterns is likely, to recruit the different sets of cortical neurons, and thus contributes to a variety of prefrontal functions. J. Comp. Neurol. 525:166–185, 2017. © 2016 Wiley Periodicals, Inc.

    DOI： 10.1002/cne.24054

    Web of Science

    Scopus

    PubMed

  • Ozeki Kazuhide, Goto Tetsuya, Aoki Hideki .  Preparation of hydroxyapatite thin films on PEEK using sputtering method and its bone formation .  Journal of Bio-Integration7 ( 1 ) 81 - 85   2017

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    Publisher：Bio Integration Society  

    Polyetheretherketone (PEEK) is a semi-crystalline polymer with outstanding mechanical properties, bone-likestiffness and suitable biocompatibility that has attracted much interest as a biomaterial for dental implants.However, the bio-inert surface of the PEEK limits its medical applications when direct osteintegration betweenthe implants and the host tissue. In this work, we fabricated hydroxyapatite (HA) thin films on a PEEK substratewith a titanium (Ti) intermediate layer using a sputtering to improve adhesion strength of the HA filmto the PEEK. The HA film was not coated without the Ti intermediate layer, whereas the HA films with the Tiintermediate layer was successfully fabricated on the PEEK regardless of the thickness of the Ti intermediatelayers. The HA films with 5 and 10 nm Ti intermediated layer have transparency. In the cell culture, the boneformation area on the HA film with 100 nm Ti intermediated layer was larger than that on the HA film with 5nm Ti intermediated layer.

    DOI： 10.32176/biointeg.7.1_81

  • Iwai H, Kuramoto E, Yamanaka A, Sonomura T, Uemura M, Goto T. .  Ascending parabrachio-thalamo-striatal pathways: Potential circuits for integration of gustatory and oral motor functions. .  Neuroscience294   1 - 13   2015.5Ascending parabrachio-thalamo-striatal pathways: Potential circuits for integration of gustatory and oral motor functions.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Yamanaka A, Iwai H, Uemura M, Goto T. .  Patterning of mammalian heterodont dentition within the upper and lower jaws. .  Evol Dev.17 ( 2 ) 127 - 138   2015.3Patterning of mammalian heterodont dentition within the upper and lower jaws.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Nagao S, Goto T, Kataoka S, Toyono T, Egusa H, Yatani H, Maki K. .  Expression of neuropeptide receptor mRNA during osteoblastic differentiation of mouse iPS cells. .  Neuropeptides28 ( 6 ) 399 - 406   2014.6Expression of neuropeptide receptor mRNA during osteoblastic differentiation of mouse iPS cells. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Ozeki K, Goto T, Aoki F, Masuzawa T. .  Fabrication of hydroxyapatite thin films on zirconia using a sputtering technique. .  Biomed Mater Eng.24 ( 5 ) 1793 - 1802   2014.5Fabrication of hydroxyapatite thin films on zirconia using a sputtering technique. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Ozeki K, Goto T, Aoki H, Masuzawa T. .  Characterization of Sr-substituted hydroxyapatite thin film by sputtering technique from mixture targets of hydroxyapatite and strontium apatite. .  Biomed Mater Eng.24 ( 5 ) 1447 - 1456   2014.2Characterization of Sr-substituted hydroxyapatite thin film by sputtering technique from mixture targets of hydroxyapatite and strontium apatite.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Fukuda A, Goto T, Kuroishi KN, Gunjigake KK, Kataoka S, Kobayashi S, Yamaguchi K. .  Hemokinin-1 competitively inhibits substance P-induced stimulation of osteoclast formation and function. .  Neuropeptides47 ( 4 ) 1147 - 1156   2013.4Hemokinin-1 competitively inhibits substance P-induced stimulation of osteoclast formation and function.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Kurata, S., Goto, T., Gunjigake, K. K., Kataoka, S., Kuroishi, K. N., Ono, K., Toyono, T., Kobayashi, S., Yamaguchi, K. .  Nerve growth factor involves mutual interaction between neurons and satellite glial cells in the rat trigeminal ganglion. .  Acta Histochem Cytochem46   65 - 73   2013.1Nerve growth factor involves mutual interaction between neurons and satellite glial cells in the rat trigeminal ganglion. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Tanaka K, Goto T, Miyazaki T, Morita Y, Kobayashi S, Takahashi T. .  Apatite-coated hyaluronan for bone regeneration. .  J Dent Res90 ( 7 ) 906 - 911   2011.7Apatite-coated hyaluronan for bone regeneration. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Ichiki T, Kuroishi KN, Gunjigake KK, Kobayashi S, Goto T. .  Neurokinin B activates the formation and bone resorption activity of rat osteoclasts. .  Neuropeptides45 ( 3 ) 239 - 244   2011.6Neurokinin B activates the formation and bone resorption activity of rat osteoclasts.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Kodama T, Goto T, Miyazaki T, Takahashi T. .  Bone formation on apatite-coated titanium incorporated with bone morphogenetic protein and heparin. .  Int J Oral Maxillofac Implants23 ( 6 ) 1013 - 1019   2008.11Bone formation on apatite-coated titanium incorporated with bone morphogenetic protein and heparin.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Nakao K, Goto T, Gunjigake KK, Konoo T, Kobayashi S, Yamaguchi K. .  Intermittent force induces high RANKL expression in human periodontal ligament cells. .  J Dent Res86 ( 7 ) 623 - 628   2007.7Intermittent force induces high RANKL expression in human periodontal ligament cells. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Matayoshi T, Goto T, Fukuhara E, Takano H, Kobayashi S, Takahashi T .  Neuropeptide substance P stimulates the formation of osteoclasts via synovialfibroblastic cells. .  Biochem Biophys Res Commun.327 ( 3 ) 756 - 764   2005.2Neuropeptide substance P stimulates the formation of osteoclasts via synovialfibroblastic cells.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Goto T, Kajiwara H, Yoshinari M, Fukuhara E, Kobayashi S, Tanaka T. .  In vitro assay of mineralized-tissue formation on titanium using fluorescent staining with calcein blue. .  Biomaterials24 ( 22 ) 3885 - 3892   2003.10In vitro assay of mineralized-tissue formation on titanium using fluorescent staining with calcein blue.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Goto T, Maeda H, Tanaka T. .  A selective inhibitor of matrix metalloproteinases inhibits the migration of isolated osteoclasts by increasing the life span of podosomes. .  J Bone Miner Metab20 ( 2 ) 98 - 105   2002.4A selective inhibitor of matrix metalloproteinases inhibits the migration of isolated osteoclasts by increasing the life span of podosomes.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Goto T, Wong KS, Brunette DM .  Observation of fibronectin distribution on the cell undersurface using immunogold scanning electron microscopy. .  J Histochem Cytochem47 ( 11 ) 1487 - 1494   2001.11Observation of fibronectin distribution on the cell undersurface using immunogold scanning electron microscopy.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Okumura A, Goto M, Goto T, Yoshinari M, Masuko S, Katsuki T, Tanaka T. .  Substrate affects the initial attachment and subsequent behavior of humanosteoblastic cells (Saos-2). .  Biomaterials22 ( 16 ) 2263 - 2271   2001.8Substrate affects the initial attachment and subsequent behavior of humanosteoblastic cells (Saos-2).Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Yamaza T, Goto T, Kamiya T, Kobayashi Y, Sakai H, Tanaka T. .  Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur. .  Bone23 ( 6 ) 449 - 509   1998.12Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Goto T, Brunette DM .  Surface topography and serum concentration affect the appearance of tenascin in human gingival fibroblasts in vitro. .  Exp Cell Res224 ( 2 ) 474 - 480   1998.11Surface topography and serum concentration affect the appearance of tenascin in human gingival fibroblasts in vitro. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Goto T, Yamaza T, Kido MA, Tanaka T .  Light- and electron-microscopic study of the distribution of axons containing substance P and the localization ofneurokinin-1 receptor in bone. .  Cell Tissue Res293 ( 1 ) 87 - 93   1998.7Light- and electron-microscopic study of the distribution of axons containing substance P and the localization ofneurokinin-1 receptor in bone.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Nordstrom T, Shrode LD, Rotstein OD, Romanek R, Goto T, Heersche JN, Manolson MF, Brisseau GF, Grinstein S .  Chronic extracellular acidosis induces plasmalemmal vacuolar type H+ ATPase activity in osteoclasts. .  J Biol Chem272 ( 10 ) 6354 - 6360   1997.5Chronic extracellular acidosis induces plasmalemmal vacuolar type H+ ATPase activity in osteoclasts.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Goto T, Kiyoshima T, Moroi R, Tsukuba T, Nishimura Y, Himeno M, Yamamoto K,Tanaka T. .  Localization of cathepsins B, D, and L in the rat osteoclast byimmuno-light and -electron microscopy. .  Histochemistry101 ( 1 ) 33 - 40   1994.1Localization of cathepsins B, D, and L in the rat osteoclast byimmuno-light and -electron microscopy.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Immunocytochemicallocalization of cathepsin D in the rat osteoclast. .    97 ( 1 ) 13 - 18   1992.3Immunocytochemicallocalization of cathepsin D in the rat osteoclast. Reviewed

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    Language：English   Publishing type：Doctoral thesis  

    DOI： 10.1007/BF00271276

  • Goto T, Tsukuba T, Ayasaka N, Yamamoto K, Tanaka T. .  Immunocytochemicallocalization of cathepsin D in the rat osteoclast. .  Histochemistry97 ( 1 ) 13 - 8   1992.1Immunocytochemicallocalization of cathepsin D in the rat osteoclast.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

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MISC

  • Case of pemphigoid with antibodies to BP180 C-terminal domain and α3 subunit of laminin-332 associated with chronic graft-versus-host disease(和訳中)

    Kawashima Hiromichi, Kageji Riho, Hida Yasutoshi, Goto Tetsuya, Ishii Norito, Hashimoto Takashi

    The Journal of Dermatology   48 ( 9 )   e447 - e448   2021.9

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    Language：English   Publisher：John Wiley & Sons Australia, Ltd  

  • 三叉神経節の神経　免疫系システム

    後藤 哲哉, 千堂 良造, 岩井 治樹, 倉本 恵梨子, 山中 淳之

    別冊Bio Clinica: 慢性炎症と疾患   8 ( 1 )   137 - 142   2019.7

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    Publisher：(株)北隆館  

    三叉神経節内では、神経細胞体が塊状に集まって体部位局在を示す。神経細胞体は衛星細胞で囲まれ、相互に情報伝達を行なっている。三叉神経が末梢で侵害刺激を受けると神経細胞は周囲のマクロファージ様細胞の増殖と活性化を誘導する。活性化したマクロファージ様細胞は、神経細胞に直接コンタクトする。特にC線維を有する神経細胞が産生するサブスタンスPやCGRPは、逆行性に侵害刺激部位に輸送・放出され、炎症のモジュレーターとして働く。三叉神経節では一次防御機構と呼ぶべき神経-免疫系システムを構築している。(著者抄録)

  • 三叉神経節の神経-免疫系システム

    後藤 哲哉

    別冊BIO Clinica   8 ( 1 )   137 - 142   2019.6

  • 歯の喪失はアルツハイマー病モデルマウスの脳幹におけるM1型ミクログリア分化を促進する

    後藤 哲哉, ダール・アシス, 倉本 恵梨子, 岩井 治樹, 山中 淳之, 松本 信英, 原 博満

    Journal of Oral Biosciences Supplement   2018   398 - 398   2018.9

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    Publisher：(一社)歯科基礎医学会  

  • 三叉神経節における神経ペプチド類とATPシグナル伝達(Neuropeptides and ATP signaling in the trigeminal ganglion)

    Goto Tetsuya, Iwai Haruki, Kuramoto Eriko, Yamanaka Atsushi

    The Japanese Dental Science Review   53 ( 3-4 )   117 - 124   2017.11

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    Publisher：日本歯科医学会  

  • 顎骨壊死はなぜ起こる?(2)

    後藤 哲哉

    保団連   ( 1247 )   45 - 48   2017.9

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    Publisher：全国保険医団体連合会  

  • アルツハイマー病モデルマウスの抜歯後の行動変化ならびに組織学的解析

    関 遥, Ashis Dhar, 岩井 治樹, 倉本 恵梨子, 山中 淳之, 後藤 哲哉, 松本 信英, 原 博満

    Journal of Oral Biosciences Supplement   2017   394 - 394   2017.9

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    Publisher：(一社)歯科基礎医学会  

  • 抜歯はアルツハイマー病モデルマウスの中脳路核神経細胞のタウ・リン酸化を誘導する

    後藤 哲哉, 倉本 恵梨子, Ashis Dhar, 岩井 治樹, 山中 淳之, 松本 信英, 原 博満, 道川 誠

    Journal of Oral Biosciences Supplement   2017   265 - 265   2017.9

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    Publisher：(一社)歯科基礎医学会  

  • 顎骨壊死はなぜ起こる?(1)

    後藤 哲哉

    保団連   ( 1245 )   45 - 48   2017.8

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    Publisher：全国保険医団体連合会  

  • 食物の好き嫌いを生み出す脳のメカニズム

    岩井治樹, 倉本恵梨子, 山中淳之, 後藤哲哉

    鹿歯会報 TEETHful   131 ( 710 )   9 - 11   2017.4

  • 【歯内療法領域の画像診断-歯科用CBCTの適切な運用と解剖学的・病理学的知識を整理する】画像診断における解剖学的根管形態の捉え方

    後藤 哲哉

    日本歯科評論   77 ( 3 )   37 - 47   2017.3

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    Language：Japanese   Publisher：(株)ヒョーロン・パブリッシャーズ  

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Presentations

  • 園田 怜美, 倉本 恵梨子, 南 総一郎, 後藤 哲哉, 野口 和行   歯の喪失がアルツハイマー病の進行に影響を与えるメカニズムについて  

    日本歯周病学会会誌  2022.5  (NPO)日本歯周病学会

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    Language：Japanese  

  • 後藤 哲哉   歯の喪失がアルツハイマー病を発症させるメカニズムの解明  

    日本歯科医学会誌  2019.3  日本歯科医学会

  • 後藤 哲哉   歯の喪失がアルツハイマー病を発症させるメカニズムの解明  

    第34回「歯科医学を中心とした総合的な研究を推進する集い」  2018.8 

  • 後藤 哲哉, 倉本 恵梨子, ダール・アシス , 松本 信英, 原 博満, 山中 淳之, 岩井 治樹, 道川 誠   歯の喪失がアルツハイマー病を誘発させるメカニズムについて  

    Dementia Japan  2018.9  (一社)日本認知症学会

  • Taslima Ferdous, Jung Cha-Gyun, Zhou Chunyu, Abdullah Mohammad, Abdelhamid Mona, Dhar Ashis, Goto Tetsuya, Saito Takashi, Saido Takaomi C., Michikawa Makoto   歯の喪失が記憶障害およびAD病態に及ぼす影響(Effect of tooth loss on memory impairment and AD pathology)  

    Dementia Japan  2019.10  (一社)日本認知症学会

  • 後藤 哲哉, 倉本 恵梨子, Ashis Dhar, 松本 信英, 原 博満, 山中 淳之, 岩井 治樹, 大八木 保政, 道川 誠   歯の喪失はpre-dementiaからdementiaへの進行を早める  

    Dementia Japan  2019.10  (一社)日本認知症学会

  • 後藤 哲哉, ダール・アシス , 倉本 恵梨子, 岩井 治樹, 山中 淳之, 松本 信英, 原 博満   歯の喪失はアルツハイマー病モデルマウスの脳幹におけるM1型ミクログリア分化を促進する  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 山中 淳之, 岩井 治樹, 倉本 恵梨子, Dhar Ashis, 後藤 哲哉   歯胚上皮の陥入および形態形成過程における非筋ミオシンIIの役割  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 山中 淳之, 後藤 哲哉   歯胚上皮の陥入および形態形成過程初期における非筋ミオシンIIの役割  

    口腔組織培養学会誌  2020.3  日本口腔組織培養学会

  • 山中 淳之, 岩井 治樹, 倉本 恵梨子, Dhar Ashis, 後藤 哲哉   現生トガリネズミ科の臼歯の発生は中生代化石哺乳類の臼歯の進化を再現する  

    Journal of Oral Biosciences Supplement  2017.9  (一社)歯科基礎医学会

  • 後藤 哲哉   軽度認知症期における歯の喪失は認知症への進行を促進するメカニズムの解明  

    日本老年歯科医学会総会・学術大会プログラム・抄録集  2019.6  (一社)日本老年歯科医学会

  • 後藤 哲哉   軽度認知症期における歯の喪失は認知症への進行を促進するメカニズムの解明  

    老年歯科医学  2019.9  (一社)日本老年歯科医学会

  • 後藤 哲哉   顎骨壊死はなぜおこる？  

    鹿児島県保険医協会・医科歯科合同研究会  2018.6 

  • 小柳 宏太郎, 八木 孝和, 倉本 恵梨子, 後藤 哲哉, 宮脇 正一   新規骨固定源を用いた持続的な荷重負荷による骨形成促進の新たな試み  

    九州矯正歯科学会雑誌  2017.3  九州矯正歯科学会

  • 園田 怜美, 倉本 恵梨子, 松本 信英, 原 博満, 大八木 保政, 野口 和行, 後藤 哲哉   3xTg-ADマウスにおける神経細胞内アミロイドβの加齢変化について  

    Dementia Japan  2020.10  (一社)日本認知症学会

  • 園田 怜美, 倉本 恵梨子, 後藤 哲哉   3xTg-ADマウスを用いた神経細胞におけるアミロイドβの局在と加齢変化について  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • Ashis Dhar, 倉本 恵梨子, 岩井 治樹, 山中 淳之, 後藤 哲哉   C57BL/6Jマウスにおける三叉神経中脳路核の神経変性に対する上顎臼歯抜歯の影響(The effects of maxillary molar extraction on the neurodegeneration of the trigeminal mesencephalic nucleus in C57BL/6J mice)  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 後藤 哲哉   Neurodegeneration by Tooth Loss Causes Cognitive Impairment  

    Kyudai Oral Bioscience 2018  2018.2 

  • 後藤 哲哉   Neurodegeneration by Tooth Loss is a Risk Factor for the Initiation of Alzheimer's Disease  

    International Alzheimer's Disease Conference 2018( Hong Kong)  2018.9 

  • GOTO Tetsuya   Neurogeneration Induced by Tooth-Loss  

    International Association For Dental Research  2019.7 

  • 八木 孝和, 倉本 恵梨子, 関 遥, 齋藤 充, 岩井 治樹, 山中 淳之, 後藤 哲哉   アルツハイマー病モデルマウスにおける三叉神経系の神経変性が咀嚼機能に与える影響  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 関 遥, Ashis Dhar, 岩井 治樹, 倉本 恵梨子, 山中 淳之, 後藤 哲哉, 松本 信英, 原 博満   アルツハイマー病モデルマウスの抜歯後の行動変化ならびに組織学的解析  

    Journal of Oral Biosciences Supplement  2017.9  (一社)歯科基礎医学会

  • 後藤 哲哉   アルツハイマー病研究の新展開　三叉神経の神経変性とアルツハイマー病　歯の喪失がアルツハイマー病の進行を早めるメカニズム  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • 後藤 哲哉   オーラル・バイオロジーの老化研究への新たな挑戦　アルツハイマー病の進行に関わる三叉神経中脳路核の老化について  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • 岩井 治樹, 倉本 恵梨子, ダール・アシス , 山中 淳之, 後藤 哲哉   マウス三叉神経節のM2型組織常在性マクロファージ様細胞は末梢神経傷害によって増殖・活性化する  

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

  • 岩井 治樹, 倉本 恵梨子, 山中 淳之, ダール・アシス , 後藤 哲哉   マウス三叉神経節のマクロファージ様細胞は神経傷害によって増殖・活性化する  

    Journal of Oral Biosciences Supplement  2017.9  (一社)歯科基礎医学会

  • 倉本 恵梨子, 岩井 治樹, 山中 淳之, 後藤 哲哉   マウス大脳皮質の運動野において、錐体ニューロンからパルブアルブミン陽性インターニューロンへの入力を定量的に解析する  

    Journal of Oral Biosciences Supplement  2019.10  (一社)歯科基礎医学会

  • 千堂 良造, 杉村 光隆, 糀谷 淳, 眞鍋 庸三, 山形 和彰, 山下 薫, 後藤 哲哉   ラット三叉神経節における組織透明化の応用と細胞体局在の検討  

    日本顎関節学会雑誌  2018.7  (一社)日本顎関節学会

  • 千堂 良造, 杉村 光隆, 糀谷 淳, 眞鍋 庸三, 山形 和彰, 山下 薫, 後藤 哲哉   ラット三叉神経節における組織透明化の応用と細胞体局在の検討  

    日本歯科心身医学会雑誌  2018.12  (一社)日本歯科心身医学会

  • 桑原 晴樹, 花岡 吉亀, 後藤 哲哉, 本郷 一博   三叉神経痛に対する微小血管減圧術後の両側性外転神経麻痺(Bilateral abducens nerve palsy after microvascular decompression for trigeminal neuralgia)  

    信州医学雑誌  2018.8  信州医学会

  • 八木 孝和, 齋藤 充, 後藤 哲哉, 小柳 宏太郎, 菅 真有, 宮脇 正一   副腎皮質刺激ホルモン放出ホルモンの脳内投与が顎機能に及ぼす影響  

    日本矯正歯科学会大会プログラム・抄録集  2018.10  (公社)日本矯正歯科学会

  • Iwai Haruki, Kuramoto Eriko, Yamanaka Atsushi, Goto Tetsuya   感覚と中枢性自律神経調節　結合腕傍核を起点とする線条体腹側部の機能形態学　摂食行動と味覚および内臓感覚とを結びつける神経回路(Sensation and central autonomic regulation　Functional morphology of the ventral part of the caudate putamen originating from the parabrachial nucleus: Neural circuits connecting between feeding behavior and gustatory and visceral senses)  

    日本自律神経学会総会プログラム・抄録集  2017.8  日本自律神経学会

  • Ashis Dhar, 後藤 哲哉   抜歯によるPDL損傷に起因したVmes-Vmoの神経変性(Neurodegeneration of Vmes-Vmo due to PDL damage by tooth extraction)  

    Dementia Japan  2020.10  (一社)日本認知症学会

  • 後藤 哲哉, 倉本 恵梨子, Ashis Dhar, 岩井 治樹, 山中 淳之, 松本 信英, 原 博満, 道川 誠   抜歯はアルツハイマー病モデルマウスの中脳路核神経細胞のタウ・リン酸化を誘導する  

    Journal of Oral Biosciences Supplement  2017.9  (一社)歯科基礎医学会

  • Dhar Ashis, 倉本 恵梨子, 岩井 治樹, 山中 淳之, 後藤 哲哉   損傷した歯周靱帯はC57BL/6Jマウスにおいて三叉神経中脳路核と運動核の神経変性を誘発する(The damaged periodontal ligament induces trigeminal mesencephalic and motor nuclei neurodegeneration in C57BL/6J mice)  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

  • 小柳 宏太郎, 八木 孝和, 倉本 恵梨子, 後藤 哲哉, 宮脇 正一   新規骨固定源を用いた持続的な荷重負荷による骨形成促進について  

    九州矯正歯科学会雑誌  2018.3  九州矯正歯科学会

  • 小柳 宏太郎, 八木 孝和, 倉本 恵梨子, 後藤 哲哉, 宮脇 正一   新規骨固定源を用いた持続的な荷重負荷による骨形成促進について  

    九州矯正歯科学会雑誌  2019.2  九州矯正歯科学会

  • 後藤 哲哉   老いの入り"口"から認知症を読み解く　口腔機能と神経細胞変性　加齢、歯の喪失、アルツハイマー病の関係について  

    日本抗加齢医学会総会プログラム・抄録集  2021.6  (一社)日本抗加齢医学会

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  • 後藤 哲哉   歯の喪失は三叉神経中脳路核の神経細胞死を介し三叉神経運動核の神経変性を生じる  

    老年歯科医学  2021.3  (一社)日本老年歯科医学会

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  • 後藤 哲哉   歯の喪失は三叉神経中脳路核の神経細胞死を介し三叉神経運動核の神経変性を生じる  

    日本老年歯科医学会総会・学術大会プログラム・抄録集  2020.11  (一社)日本老年歯科医学会

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  • 後藤 哲哉   歯の喪失がアルツハイマー病の進行を早めるメカニズムについて  

    日本歯科医師会雑誌  2021.7  (公社)日本歯科医師会

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  • 北脇 綾乃, 倉本 恵梨子, 齋藤 充, 河野 博史, 岩井 治樹, 山中 淳之, 後藤 哲哉   アルツハイマーモデルマウス3xTG-ADの三叉神経系における病理所見と咀嚼機能についての研究(Pathologies of the trigeminal nervous system, and delayed masticatory rhythm in triple-transgenic mouse model of Alzheimer's disease)  

    Journal of Oral Biosciences Supplement  2021.10  (一社)歯科基礎医学会

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  • Kitawaki Ayano, Esaki Harukiyo, Oda Hinano, Katsuyama Kouki, Kinoshita Teruki, Susa Megumi, Taniguchi Masayoshi, Kuramoto Eriko, Saito Mitsuru, Kono Hiroshi, Yagi Takakazu, Matsumoto Shinei, Hara Hiromitsu, Iwai Haruki, Yamanaka Atsushi, Goto Tetsuya   アルツハイマー病モデルマウス3xTg-ADの三叉神経系における病理所見と咀嚼運動についての研究(Pathologies of the trigeminal nervous system, and delayed masticatory rhythm in triple-transgenic mouse model of Alzheimer's disease)  

    The Journal of Physiological Sciences  2021.8  (一社)日本生理学会

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  • 北脇 綾乃, 倉本 恵梨子, 齋藤 充, 山中 淳之, 岩井 治樹, 後藤 哲哉   アルツハイマー病モデルマウスの中脳路核でみられたアミロイドβとリン酸化タウの沈着と、その咀嚼機能への影響(Neuropathology in the mesencephalic trigeminal nucleus of Alzheimer's disease model mice and its effects on masticatory function)  

    Journal of Oral Biosciences Supplement  2021.10  (一社)歯科基礎医学会

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  • 倉本 恵梨子, 福島 慎, 岩井 治樹, 山中 淳之, 杉村 光隆, 後藤 哲哉   ラット三叉神経節の三次元的な体部位局在と異所性疼痛の関連性についての研究(A study of the relationship between three-dimensional somatotopy of the rat trigeminal ganglion and ectopic pain)  

    Journal of Oral Biosciences Supplement  2021.10  (一社)歯科基礎医学会

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  • ハイデル・エムデイヤシン , 岩井 治樹, 倉本 恵梨子, 後藤 哲哉, 中村 典史, 山中 淳之   小臼歯と大臼歯の咬頭の相同性に関する発生学的検討(Developmental assessment on the cusp homologies between the premolar and the molar)  

    Journal of Oral Biosciences Supplement  2021.10  (一社)歯科基礎医学会

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  • Yamanaka Atsushi, Haier Yasin, Taguchi Urara, Kuramoto Eriko, Iwai Haruki, Goto Tetsuya   現生トガリネズミの大臼歯における咬頭形成の発生学的順番　中生代哺乳類のトリボスフェニック型臼歯の進化への発生学的考察(Developmental sequence of cusp formation in the modern shrew's molar: an implication for the evolution of tribosphenic molar in Mesozoic mammals)  

    The Journal of Physiological Sciences  2021.8  (一社)日本生理学会

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  • Fukushima Makoto, Kuramoto Eriko, Sendo Ryozo, Iwai Haruki, Yamanaka Atsushi, Sugimura Mitsutaka, Goto Tetsuya   逆行性トレーサーと組織透明化技術の組み合わせによるラット三叉神経節の三次元体部位局在の解明(Three-Dimensional topography of the rat trigeminal ganglion neurons with combination of retrograde labeling and tissue clearing techniques)  

    The Journal of Physiological Sciences  2021.8  (一社)日本生理学会

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  • 園田 怜美, 倉本 恵梨子, 松本 信英, 原 博満, 大八木 保政, 野口 和行, 後藤 哲哉   三叉神経中脳路核の神経変性によるアミロイドβオリゴマーの拡散について  

    Dementia Japan  2021.10  (一社)日本認知症学会

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  • 後藤 哲哉   アルツハイマー病モデルマウスの三叉神経中脳路核神経細胞におけるアミロイドβの局在と加齢変化について  

    老年歯科医学  2021.9  (一社)日本老年歯科医学会

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Awards

  • 「第34回歯科医学を中心とした総合的な研究を推進する集い」優秀発表賞

    2018.8   日本歯科医学会  

    後藤 哲哉

Research Projects

  • 歯の喪失による神経変性がアルツハイマー病を発症させる分子メカニズムの解明

    2020.4 - 2024.3

    科学研究費補助金  基盤研究(C)

  • 三叉神経節の神経-免疫系をターゲットとした顎顔面痛覚異常の病態解明と治療法の開発

    2017.4 - 2019.3

    日本学術振興会  挑戦的研究（萌芽） 

    後藤 哲哉

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  • ATPによる象牙芽細胞からの神経伝達機構の解明

    2014.4 - 2017.3

    日本学術振興会  基盤研究(c)・代表 

    後藤 哲哉

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  • 表面装飾の異なるチタン(T)植立時歯肉-T接合性と骨-T結合性の相違に関する研究

    日本学術振興会  萌芽的研究・分担 

    田中 輝男

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Teaching Experience

  • 口腔解剖学

  • 組織学

  • 解剖学