Faculty Profiles - AKASAKI Yuichi

写真a

AKASAKI Yuichi

Organization

University Hospital, Medical and Dental Sciences Area University Hospital Clinical Center Cardiovascular Center Lecturer

Degree

博士（医学） ( 2006.8 鹿児島大学 )

Research Areas

Life Science / Cardiology

Research History

Kagoshima University Lecturer

2023.4
Kagoshima University Lecturer

2023.4
Kagoshima University Assistant Professor

2013.12

Professional Memberships

日本老年病学会

2015.10
日本高血圧学会

2013.4
日本動脈硬化学会

2003.4
日本循環器学会

2000.4
日本内科学会

1999.4

Papers

Tokutake Daisuke, Akasaki Yuichi, Shinchi Shuya, Uebo Shota, Kawasoe Shin, Kubozono Takuro, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru . Association Between Fatty Liver Index and Brachial-Ankle Pulse Wave Velocity in the General Population　― A Cross-Sectional Study ― . Circulation Reports8 ( 1 ) 118 - 126 2026.1

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Language：English Publisher：The Japanese Circulation Society

Background: Although metabolic dysfunction-associated fatty liver disease is typically diagnosed using ultrasonography, the fatty liver index (FLI) offers a simple alternative. Brachial-ankle pulse wave velocity (baPWV) is an established marker of arterial stiffness and a predictor of cardiovascular events. This study investigated the association between FLI and baPWV in a general Japanese population.Methods and Results: This cross-sectional study included participants aged ≥18 years, excluding those with atrial fibrillation, lower extremity artery disease, severe aortic stenosis, or missing data. The primary outcome was an elevated baPWV (≥1,800 cm/s). Multivariable logistic regression analysis was performed to assess the association between FLI and elevated baPWV, considering FLI both as a categorical variable (low risk: FLI <30; moderate risk: FLI ≥30 and <60; high risk: FLI ≥60) and as a continuous variable (per 10-unit increase). The analysis included 10,122 individuals (mean age 54.3 years; 55% male). In multivariable-adjusted models, the odds of elevated baPWV were significantly higher in the moderate-risk (odds ratio [OR] 1.47; 95% confidence interval [CI] 1.20–1.79) and high-risk (OR 1.78; 95% CI 1.33–2.38) groups, using the low-risk group as the reference category. Each 10-unit increase in FLI was associated with significantly higher odds of the outcome (OR 1.16; 95% CI 1.10–1.22).Conclusions: FLI showed a significant association with arterial stiffness in the general Japanese population.

DOI： 10.1253/circrep.cr-25-0218

PubMed

CiNii Research
Uebo S., Ikeda Y., Uchikado Y., Sasaki Y., Akasaki Y., Kubozono T., Ohishi M. . Disruption of Rab9-dependent mitophagy contributes to menopause-induced sarcopenia . Experimental Gerontology213 112970 2026.1

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Language：Japanese Publisher：Experimental Gerontology

Aim Sarcopenia, a major cause of frailty in postmenopausal women, is linked to mitochondrial dysfunction, but the underlying mechanisms remain unclear. This study aimed to clarify whether mitophagy, a mitochondrial quality control mechanism, contributes to postmenopausal sarcopenia, to elucidate its underlying mechanism, and to assess whether it can be rescued. METHODS: C57BL/6 mice (12-week-old females) underwent ovariectomy to establish a menopause mouse model, or sham surgery, and the therapeutic effects of nicotinamide mononucleotide (NMN) were assessed. Human skeletal muscle myoblasts (HSMMs) differentiated under postmenopausal conditions with or without 17β-estradiol (E2), and Rab9 expression was modulated using CRISPR activation. RESULTS: Ovariectomized mice exhibited decreased muscle mass and strength. E2 deficiency in HSMMs inhibited skeletal muscle cell differentiation, promoted senescence, impaired mitochondrial function, and reduced mitophagy. However, E2 deficiency did not modulate light chain 3 and autophagy-related 7 but reduced Rab9 expression and the colocalization of Rab9 with lysosomal-associated membrane protein 2, suggesting that E2 mediates mitophagy through Rab9-dependent alternative autophagy. Furthermore, overexpression of Rab9 in E2-deficient HSMMs enhanced mitophagy, improved mitochondrial function, suppressed cellular senescence, and promoted skeletal muscle cell differentiation. The administration of NMN to ovariectomized mice increased Rab9 expression and improved sarcopenia through increased mitophagy. CONCLUSION: This study demonstrates that estrogen deficiency impairs mitophagy originated from Rab9-dependent alternative autophagy, leading to mitochondrial dysfunction and sarcopenia, while enhancement of Rab9 restores mitochondrial quality control and muscle function. These results identify Rab9-dependent mitophagy as a potential therapeutic target for postmenopausal sarcopenia.

DOI： 10.1016/j.exger.2025.112970

Scopus

PubMed
Shimokihara S., Tabira T., Maruta M., Makizako H., Han G., Kamasaki T., Akasaki Y., Hidaka Y., Kumura Y., Kukizaki W., Kubozono T., Ohishi M. . Associations Between the Diverse Aspects of Psychological Frailty and Health-Related Outcomes in Community-Dwelling Older Adults: A Cross-Sectional Study . Psychogeriatrics26 ( 1 ) e70115 2026.1

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Language：Japanese Publisher：Psychogeriatrics

Background: Psychological frailty (PsF), encompassing cognitive and emotional vulnerabilities, remains understudied despite its potential impact on health outcomes in older adults. This cross-sectional study aimed to explore the characteristics of diverse aspects of PsF, including cognitive frailty (CF), lower cognitive function, and affective frailty (AF), and to examine their associations with health-related outcomes in community-dwelling older adults. Methods: Data were analysed from 420 community-dwelling older adults participating in the Tarumizu Study in Japan, excluding those exhibiting physical or social frailty. Participants were categorised into Robust, Lower cognitive function, CF, AF, and Multi-domain PsF groups. AF was assessed using five items from the Geriatric Depression Scale, focusing on emotional vulnerability. Health outcomes included self-rated health, subjective memory complaints (SMC), and functional ability of daily living. Associations were analysed using adjusted multiple regression models controlling for covariates. Results: PsF was present in 39.5% of the cohort (lower cognitive function: 18.1%, CF: 7.6%, AF: 11.0%, Multi-domain PsF: 2.9%). In the adjusted models, only AF showed a significant positive association with SMC (adjusted risk ratio = 1.62, 95% CI: 1.06–2.42, p = 0.023). No significant associations were found between any PsF domain and subjective health or daily functional ability in the adjusted models. Conclusions: AF, characterised by emotional vulnerability, was uniquely associated with SMC, suggesting emotional factors may play a more central role than cognitive decline in shaping perceptions of memory problems. These findings highlight the heterogeneous nature of PsF and underscore the need for nuanced assessments to inform targeted prevention and intervention strategies.

DOI： 10.1111/psyg.70115

Scopus

PubMed
Matsumoto K., Hamatani S., Mizuno Y., Maeno A., Kasai M., Watanabe K., Kamashita R., Sunami N., Ikeda M., Nagata S., Inoue M., Kimura Y., Yokoo M., Kunisato Y., Akasaki Y., Nakamura M. . Self-help cognitive behavioral therapy for gaze anxiety in young adults: Protocol of a 3-arms, multicenter, randomized controlled trial . Psychiatry and Clinical Neurosciences Reports4 ( 4 ) e70236 2025.12

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Language：Japanese Publisher：Psychiatry and Clinical Neurosciences Reports

Background: Gaze anxiety (scopophobia) is a frequently observed and reported symptom that is closely associated with social anxiety disorder (SAD). Considering the efficacy of cognitive behavioral therapy (CBT) for social anxiety, it may also be beneficial for individuals with gaze anxiety. Self-help CBT can offer a means of early intervention; however, its effectiveness remains unclear. Methods: This protocol describes the design of a clinical trial aimed at evaluating the efficacy of two self-help CBT interventions for gaze anxiety. This multicenter randomized controlled trial is planned across 12 institutions in Japan. The participants will be young adults aged 18–30 years who report anxiety and avoidance related to gazes. The enrolled participants will be randomly assigned to either a self-help book CBT group, a web-based CBT group, or a control group. The severity of gaze anxiety, as the primary outcome, will be assessed using online questionnaires at baseline, 3 months post-intervention, and the 6-month follow-up, with effectiveness evaluated through statistical analysis using mixed-effects models. Results: The clinical trial will be performed from April 2025 to March 2026, and the results of this study are expected to be available by mid-2026. The results of this trial will provide insights into the effectiveness of self-help CBT for gaze anxiety (scopophobia). Conclusions: This trial will examine whether self-help CBT improves access and whether it is effective for adolescents and young adults with social anxiety, especially gaze anxiety.

DOI： 10.1002/pcn5.70236

Scopus

PubMed
Shimokihara S., Tabira T., Ikeda Y., Maruta M., Han G., Kamasaki T., Hidaka Y., Akasaki Y., Kukizaki W., Kumura Y. . Association between smartphone glances during application-based navigation and pedestrian navigation performance: a real-world experimental study . Mhealth11 1 - 11 2025.10

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Language：Japanese Publisher：Mhealth

Background: The percentage of people owning smartphones is rapidly increasing due to the digitalization of modern society. Among the smartphone’s features, route guidance using navigation applications establishes spontaneous and independent outdoor mobility, and can potentially support people’s health. Despite some known concerns regarding smartphone use while walking, navigation performance and eye-tracking behavior while walking with navigation applications in real-world environments are unclear. This study aimed to investigate the association between gaze behavior, particularly glancing at smartphones, and navigation performance among adult users of navigation applications while walking. Methods: This cross-sectional experimental study involved 33 healthy adults aged 20 years and older (20–81 years, 66.7% female) not requiring assistance with walking or activities of daily living. A route navigation task (RNT) of approximately 1,300 m was performed in a real outdoor environment. The participants were required to complete the route as quickly as possible, following the instructions of the navigation application. Simultaneously, the fixation time, number of fixations, number of saccades, total saccade angle, and number of glances at the smartphone were recorded using a wearable eye-tracking device. After checking the distribution of the obtained outcomes and performing correlation analysis, a generalized linear model (GLM) was created to investigate the relationship between the number of glances at the smartphone and the participants’ navigation performance and gaze behavior. To confirm the validity of the estimates for each GLM, a bootstrap sample of 2,000 iterations was used to evaluate the estimates. Results: Correlation analysis showed that the number of stops and route errors were moderately and positively correlated with the number of times participants glanced at their smartphones (P<0.05). In the original GLM, the number of stops and route errors showed a significant positive association with the number of glances at the smartphone (P<0.05). This significant positive relationship persisted even after examining the bootstrap sample. Conclusions: In healthy adults, frequent screen glances while walking with a navigation application may interfere with navigation performance. Establishing an alternative navigation system that does not rely on screen-checking may help pedestrians move more efficiently and safely.

DOI： 10.21037/mhealth-25-33

Scopus

PubMed
Tezuka A, Kubozono T, Kawabata T, Kawasoe S, Ojima S, Yamaguchi S, Akasaki Y, Higuchi K, Kuwahata S, Takenaka T, Nishi K, Nakamura M, Okui T, Ohishi M. . Association between toothbrushing habits and hypertension in the general population . Sci Rep. 15 ( 1 ) 35333 2025.10Reviewed

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DOI： 10.1038/s41598-025-19217-x
Kubo T, Sugiura K, Tokita Y, Takano H, Takamisawa I, Takayama M, Doi YL, Minami Y, Shirotani S, Ebato M, Tsujiuchi M, Nabeta T, Inomata T, Kato T, Okamoto R, Dohi K, Takei Y, Chikamori T, Watanabe E, Furugen A, Doi H, Akita K, Maekawa Y, Ogimoto A, Tada N, Yokota T, Ikeda S, Yamaguchi O, Izumiya Y, Shibata A, Takashio S, Tsujita K, Maejima Y, Fujino N, Nomura A, Akasaki Y, Higuchi K, Fujita S, Hoshiga M, Shiraishi Y, Ieda M, Miyamoto Y, Kitaoka H . Contemporary clinical characteristics and management patterns in hypertrophic cardiomyopathy: insights from baseline enrolment data in a nationwide prospective Japanese registry . Heart.111 ( 18 ) 885 - 892 2025.8Reviewed

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DOI： 10.1136/heartjnl-2024-324811
Tezuka A, Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Yamaguchi S, Higuchi K, Makizako H, Kuwahata S, Takenaka T, Maeda M, Fujiwara S, Ohishi M . Impact of frailty and daily living functioning on home blood pressure measurement status . Blood Press Monit. 2025.6Reviewed

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DOI： 10.1097/MBP.0000000000000767
赤﨑雄一, 大石充 . 特集肥満と循環器疾患識る3 循環器専門医の観点から . Heart View29 ( 6 ) 552 - 555 2025.6

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Publisher：メディカルレビュー社

DOI： 10.18885/hv.0000001924

CiNii Research
Akasaki Y., Suematsu Y., Azushima K., Shiga Y., Sakima A., Satoh M., Arima H., Hirawa N. . Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis . Hypertension Research48 ( 6 ) 1827 - 1838 2025.6

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Language：Japanese Publisher：Hypertension Research

Hypertension is a significant risk factor for cardiovascular diseases, with its global prevalence doubling over the past three decades. Despite advancements in antihypertensive therapies, approximately 50% of patients with hypertension fail to achieve their target blood pressure (BP) levels, underscoring the need for innovative care strategies. Patient care teams comprising multidisciplinary healthcare providers have shown promise in improving BP management. This systematic review and meta-analysis were aimed at evaluating the effectiveness of patient care teams involving physicians in hypertension management. To this end, PubMed, Cochrane CENTRAL, and IchuShi-Web were comprehensively searched and 61 randomized controlled trials including 64,857 participants were identified. Compared with usual care, interventions by patient care teams significantly reduced office systolic BP (mean difference: −6.31 mmHg; 95% confidence interval: −7.71 to −4.90) and decreased the risk of uncontrolled BP by 27% (risk ratio: 0.73; 95% confidence interval: 0.68–0.79). Subgroup analyses demonstrated consistent BP reductions across various team leadership roles, such as physicians, nurses, and pharmacists, and across different intervention durations. These findings highlight the effectiveness of team-based BP management in achieving improved BP control, regardless of team composition or the follow-up period. Multidisciplinary care offers a viable approach to addressing the unmet needs of patients with hypertension, potentially improving cardiovascular outcomes. This evidence supports integrating patient care teams into hypertension management, particularly in settings requiring physician oversight. Future research should focus on refining team structures and tailoring interventions to diverse healthcare environments to enhance their impact. (Figure presented.)

DOI： 10.1038/s41440-025-02152-9

Scopus

PubMed
Akasaki Yuichi, Suematsu Yasunori, Azushima Kengo, Shiga Yuhei, Sakima Atsushi, Satoh Michihiro, Arima Hisatomi, Hirawa Nobuhito . 患者ケアチームが高血圧患者の血圧コントロールに与える影響システマティックレビューとメタアナリシス(Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis) . Hypertension Research48 ( 6 ) 1827 - 1838 2025.6

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Language：English Publisher：Nature Publishing Group

医師を含む多職種協働による介入が高血圧患者の血圧コントロールに与える影響を調べた。各種文献データベースを検索して、組入基準を満たす無作為化比較試験61件(参加者合計64857名)を選定し、変量効果モデルを用いて統合解析を行った。その結果、高血圧管理のための多職種チーム介入は有意な血圧低下効果を示し、通常ケアとの平均値差は診察室収縮期血圧で-6.31mmHg(I2=94%)、自由行動下収縮期血圧で-8.11mmHg(I2=72%)であった。血圧管理不良の統合リスク比は0.73(95%CI 0.68～0.79、I2=95%)と、27%のリスク低下が確認された。チームでの介入による血圧改善効果は、年齢、国や地域、チーム責任者の職種、あるいは介入期間によらず、一貫して認められた。以上より、多職種の医療者がチームとして高血圧患者の血圧管理に介入することで、血圧コントロールを効果的に改善できる可能性があると考えられた。
Akasaki Yuichi, Suematsu Yasunori, Azushima Kengo, Shiga Yuhei, Sakima Atsushi, Satoh Michihiro, Arima Hisatomi, Hirawa Nobuhito . 患者ケアチームが高血圧患者の血圧コントロールに与える影響　システマティックレビューとメタアナリシス(Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis) . Hypertension Research48 ( 6 ) 1827 - 1838 2025.6

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Language：English Publisher：Nature Publishing Group

医師を含む多職種協働による介入が高血圧患者の血圧コントロールに与える影響を調べた。各種文献データベースを検索して、組入基準を満たす無作為化比較試験61件(参加者合計64857名)を選定し、変量効果モデルを用いて統合解析を行った。その結果、高血圧管理のための多職種チーム介入は有意な血圧低下効果を示し、通常ケアとの平均値差は診察室収縮期血圧で-6.31mmHg(I2=94%)、自由行動下収縮期血圧で-8.11mmHg(I2=72%)であった。血圧管理不良の統合リスク比は0.73(95%CI 0.68～0.79、I2=95%)と、27%のリスク低下が確認された。チームでの介入による血圧改善効果は、年齢、国や地域、チーム責任者の職種、あるいは介入期間によらず、一貫して認められた。以上より、多職種の医療者がチームとして高血圧患者の血圧管理に介入することで、血圧コントロールを効果的に改善できる可能性があると考えられた。
赤﨑雄一, 大石充 . 特集高血圧診療 Update 各論新しい降圧治療の立ち位置 ARNI(angiotensin receptor neprilysin inhibitor) . 腎と透析98 ( 4 ) 510 - 515 2025.4

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Publisher：東京医学社

DOI： 10.24479/kd.0000001845

CiNii Research
Shibata K, Akasaki Y, Tokushige A, Nitta M, Kawasoe S, Kubozono T, Oda K, Kumagai K, Mawatari S, Ohishi M . Blood pressure elevations post-lenvatinib treatment in hepatocellular carcinoma: a potential marker for better prognosis. . Hypertens Res.48 ( 4 ) 1542 - 1553 2025.4Reviewed

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DOI： 10.1038/s41440-025-02149-4
Shibata Keisuke, Akasaki Yuichi, Tokushige Akihiro, Nitta Mina, Kawasoe Shin, Kubozono Takuro, Oda Kohei, Kumagai Kotaro, Mawatari Seiichi, Ohishi Mitsuru . 肝細胞癌におけるレンバチニブ投与後の血圧上昇は予後良好のマーカーとなり得る(Blood pressure elevations post-lenvatinib treatment in hepatocellular carcinoma: a potential marker for better prognosis) . Hypertension Research48 ( 4 ) 1542 - 1553 2025.4

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Language：English Publisher：Nature Publishing Group

レンバチニブ投与に伴う血圧上昇と転帰の関係について検討した。対象は入院にて本剤の投与を開始した肝細胞癌患者67名(男性82.1%、年齢中央値71歳)である。血圧は入院当日と比較して投与開始翌日には高値となった。入院期間中、37.3%の患者が副作用グレード3(≧160/100mmHg)の高血圧を呈した。収縮期血圧の入院当日値から入院中最大値までの上昇量(ΔSBP)の中央値で患者を高/低群に分けて比較したところ、高群(ΔSBP≧26mmHg)は低群より死亡率が低かった。交絡因子を調整したCoxモデルにおいて、ΔSBP≧26mmHgは死亡のリスク低下と有意な関連を示した。レンバチニブ治療を受ける癌患者において、投与後の血圧上昇は予後を反映する有用な指標となる可能性がある。
Shibata Keisuke, Akasaki Yuichi, Tokushige Akihiro, Nitta Mina, Kawasoe Shin, Kubozono Takuro, Oda Kohei, Kumagai Kotaro, Mawatari Seiichi, Ohishi Mitsuru . 肝細胞癌におけるレンバチニブ投与後の血圧上昇は予後良好のマーカーとなり得る(Blood pressure elevations post-lenvatinib treatment in hepatocellular carcinoma: a potential marker for better prognosis) . Hypertension Research48 ( 4 ) 1542 - 1553 2025.4

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Language：English Publisher：Nature Publishing Group

レンバチニブ投与に伴う血圧上昇と転帰の関係について検討した。対象は入院にて本剤の投与を開始した肝細胞癌患者67名(男性82.1%、年齢中央値71歳)である。血圧は入院当日と比較して投与開始翌日には高値となった。入院期間中、37.3%の患者が副作用グレード3(≧160/100mmHg)の高血圧を呈した。収縮期血圧の入院当日値から入院中最大値までの上昇量(ΔSBP)の中央値で患者を高/低群に分けて比較したところ、高群(ΔSBP≧26mmHg)は低群より死亡率が低かった。交絡因子を調整したCoxモデルにおいて、ΔSBP≧26mmHgは死亡のリスク低下と有意な関連を示した。レンバチニブ治療を受ける癌患者において、投与後の血圧上昇は予後を反映する有用な指標となる可能性がある。
Shibata K, Akasaki Y, Tokushige A, Nitta M, Kawasoe S, Kubozono T, Oda K, Kumagai K, Mawatari S, Ohishi M . Blood pressure elevations post-lenvatinib treatment in hepatocellular carcinoma: a potential marker for better prognosis . Hypertens Res.48 ( 4 ) 1542 - 1553 2025.2Reviewed

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DOI： 10.1038/s41440-025-02149-4
Sakima Atsushi, Akagi Yuya, Akasaki Yuichi, Fujii Takako, Haze Tatsuya, Kawakami-Mori Fumiko, Kitajima Ken, Kobayashi Yusuke, Matayoshi Tetsutaro, Sakaguchi Takashi, Yamazato Masanobu, Abe Makiko, Ohya Yusuke, Arima Hisatomi . 成人の血圧管理における遠隔医療/テレヘルスのためのデジタルヘルス介入の有効性系統的レビューおよびメタ解析(Effectiveness of digital health interventions for telemedicine/telehealth for managing blood pressure in adults: a systematic review and meta-analysis) . Hypertension Research48 ( 2 ) 478 - 491 2025.2

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Language：English Publisher：Nature Publishing Group

成人の血圧(BP)管理における遠隔医療/テレヘルスのためのデジタルヘルス介入(DHI)と通常のケアを比較した無作為化対照試験または観察研究117件(参加者68677名)のメタ解析を行った。群間の加重平均差(MD)のランダム効果メタ解析を用いてデータをプールした。ベースラインから各追跡調査時までの外来BPのプールされたMDをアウトカムとした。3ヵ月間の介入により収縮期BP(SBP)は通常ケアと比べて38研究で低下し、異質性のエビデンスが示された。SBP低下は介入期間が異なっても同様にみられた(3、6ヵ月(54件)、12ヵ月(43件)、>12ヵ月(9件))。SBPと同様に拡張期BPにも効果がみられた。介入提供法(スマートフォン・アプリケーション、テキストメッセージ、ウェブサイト)や施設タイプ(医療施設、非医療施設)によらず介入はSBPを有意に低下させた。介入は非高血圧コホートよりも高血圧コホートに有効であった。
Sakima Atsushi, Akagi Yuya, Akasaki Yuichi, Fujii Takako, Haze Tatsuya, Kawakami-Mori Fumiko, Kitajima Ken, Kobayashi Yusuke, Matayoshi Tetsutaro, Sakaguchi Takashi, Yamazato Masanobu, Abe Makiko, Ohya Yusuke, Arima Hisatomi . 成人の血圧管理における遠隔医療/テレヘルスのためのデジタルヘルス介入の有効性　系統的レビューおよびメタ解析(Effectiveness of digital health interventions for telemedicine/telehealth for managing blood pressure in adults: a systematic review and meta-analysis) . Hypertension Research48 ( 2 ) 478 - 491 2025.2

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Language：English Publisher：Nature Publishing Group

成人の血圧(BP)管理における遠隔医療/テレヘルスのためのデジタルヘルス介入(DHI)と通常のケアを比較した無作為化対照試験または観察研究117件(参加者68677名)のメタ解析を行った。群間の加重平均差(MD)のランダム効果メタ解析を用いてデータをプールした。ベースラインから各追跡調査時までの外来BPのプールされたMDをアウトカムとした。3ヵ月間の介入により収縮期BP(SBP)は通常ケアと比べて38研究で低下し、異質性のエビデンスが示された。SBP低下は介入期間が異なっても同様にみられた(3、6ヵ月(54件)、12ヵ月(43件)、>12ヵ月(9件))。SBPと同様に拡張期BPにも効果がみられた。介入提供法(スマートフォン・アプリケーション、テキストメッセージ、ウェブサイト)や施設タイプ(医療施設、非医療施設)によらず介入はSBPを有意に低下させた。介入は非高血圧コホートよりも高血圧コホートに有効であった。
Salim AA, Kawasoe S, Kubozono T, Ojima S, Yamaguchi S, Higuchi K, Ikeda Y, Miyahara H, Tokushige K, Ohishi M . Association between serum uric acid levels and left ventricular hypertrophy based on electrocardiographic findings: a sex-specific analysis across cardiometabolic diseases . Sci Rep15 ( 1 ) 2319 2025.1Reviewed

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DOI： 10.1038/s41598-025-86497-8
Shimokihara S., Tabira T., Maruta M., Makizako H., Han G., Ikeda Y., Kamasaki T., Akasaki Y., Hidaka Y., Kumura Y., Kukizaki W., Nakahara R., Matsunaga S., Medina L., Kubozono T., Ohishi M. . Smartphone Proficiency in Community-Dwelling Older Adults is Associated With Higher-Level Competence and Physical Function: A Population-Based Age-Specific Cross-Sectional Study . Journal of Applied Gerontology44 ( 1 ) 52 - 61 2025.1

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Language：Japanese Publisher：Journal of Applied Gerontology

With the rapid development of information and communication technology, smartphone ownership has increased among older adults. While previous research has examined the impact of smartphone use on the health of older adults, this study focuses on the less-explored relationship between smartphone use, proficiency, and health-related outcomes including higher-level competence. The study was a cross-sectional survey of 208 community-dwelling older adults who used smartphones daily. Smartphone use, including years of use and applications, was assessed and categorized by age group. Health-related outcomes were measured, including cognitive and psychological function, higher-level competence, basic daily abilities, and physical function. The results indicated that smartphone proficiency decreased with age, with older adults primarily using basic smartphone applications. Notably, higher smartphone proficiency was positively associated with higher-level competence and physical functions. The study underscores the importance of considering smartphone proficiency when assessing older adults’ life skills and physical performance in our digital society.

DOI： 10.1177/07334648241261885

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PubMed
Akasaki Y., Shimokihara S., Hidaka Y., Maruta M., Han G., Kamasaki T., Kumura Y., Kukizaki W., Nakahara R., Makizako H., Kubozono T., Ohishi M., Tabira T. . Changes in satisfaction with meaningful activities and subsequent subjective memory complaints: a two-wave longitudinal analysis of Japanese older adults . Aging and Mental Health 1 - 12 2025

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Language：Japanese Publisher：Aging and Mental Health

Objectives: This two-wave longitudinal study examined whether changes in satisfaction with meaningful activities (MA) were associated with subsequent subjective memory complaints (SMC) among community-dwelling older adults between 2019 and 2021. Method: Health surveys were conducted among local people at two time points: baseline (2019, before the COVID-19 pandemic) and follow-up (2021, during the pandemic). The participants were 275 community-dwelling older adults aged ≥65 years without cognitive decline at baseline. Satisfaction with MA was assessed using the Aid for Decision-Making in Occupation Choice and categorized as maintained/improved or decreased at follow-up. SMC was measured using four items developed by Tsutsumimoto and quantified according to the total number of complaints. Results: Older adults who maintained or improved satisfaction with MA showed no significant increase in SMC (p = 0.30), whereas those who demonstrated decreased satisfaction experienced a significant increase in SMC (p = 0.02). In the generalized linear mixed-effects model adjusted for covariates, a significant association was observed between decreased satisfaction with MA and increased SMC scores (β = 0.32, 95% CI = 0.09–0.55, p < 0.01). Conclusion: Maintaining and improving satisfaction with MA may be associated with a reduced risk of SMC increase in older adults.

DOI： 10.1080/13607863.2025.2570823

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PubMed
Akasaki Y., Shimokihara S., Hidaka Y., Maruta M., Han G., Kamasaki T., Kumura Y., Kukizaki W., Nakahara R., Makizako H., Kubozono T., Ohishi M., Tabira T. . Satisfaction with Meaningful Activities and Sleep in Community-Dwelling Older Adults: Cross-Sectional Study . Clinical Gerontologist 1 - 15 2025

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Language：Japanese Publisher：Clinical Gerontologist

Objectives: To examine whether satisfaction with meaningful activities (MA) is associated with self-rated sleep quality and sleep duration among community-dwelling older adults. Methods: Data were drawn from 833 individuals aged ≥65 years who participated in a health survey between 2018 and 2019 in Japan. Sleep quality (good, moderate, or poor) and duration (< 6, 6–8, or ≥8 h) were assessed through a questionnaire. Participants selected the MA they considered most meaningful from a list of 95 activities in the Aid for Decision-Making in Occupation Choice, and their satisfaction with these MA were measured. Results: Ordinal logistic regression analysis, with sleep quality or duration as the dependent variable and satisfaction with MA as the independent variable, showed that higher satisfaction with MA was significantly associated with lower odds of poor sleep quality (OR: 0.84, 95% CI: 0.72–0.97, p =.03), but not with sleep duration. However, the association was not significant in sensitivity analyses that reversed the model. Conclusions: Satisfaction with MA may be associated with better sleep quality in older adults. Clinical Implications: Evaluating and enhancing satisfaction with MA may help identify older adults at risk of poor sleep quality, indicating that MA may be useful in supporting sleep.

DOI： 10.1080/07317115.2025.2597956

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PubMed
Hidaka Y., Tabira T., Maruta M., Makizako H., Han G., Shimokihara S., Akasaki Y., Kamasaki T., Kukizaki W., Nakahara R., Kubozono T., Ohishi M. . Satisfaction with grave visitation and depressive symptoms among community-dwelling older Japanese adults . Mental Health Religion and Culture 2025

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Language：Japanese Publisher：Mental Health Religion and Culture

This cross-sectional observational study aimed to clarify the relationship between satisfaction with grave visitation and depressive symptoms among Japanese older adults. We analysed older adults who participated in a community health survey (n = 1025). Participants selected meaningful activities from the 95-item Aid for Decision-Making in Occupation Choice and rated their satisfaction on a five-point scale. Depression symptoms were assessed using the 15-item Geriatric Depression Scale. Grave visitation ranked fourth among all activities and was the most frequently chosen social activity. Higher satisfaction with grave visitation was associated with a significantly lower prevalence of depression, particularly in the hopelessness dimension. After adjusting for potential covariates in a Poisson regression analysis, satisfaction with grave visitation was significantly related to depression symptoms (prevalence ratio,.58; 95% confidence interval,.35–.96). Discussing beliefs about the deceased and ancestors and helping to increase satisfaction with grave visitation may help alleviate depressive symptoms.

DOI： 10.1080/13674676.2025.2516583

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Hidaka Y., Shimokihara S., Akasaki Y., Maruta M., Han G., Kamasaki T., Kumura Y., Kukizaki W., Nakahara R., Makizako H., Kubozono T., Ohishi M., Tabira T. . Longitudinal Relationship Between Grave Visitation and Depressive Symptoms Among Community-Dwelling Older Adults . Clinical Gerontologist 1 - 12 2025

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Language：Japanese Publisher：Clinical Gerontologist

Objectives: Participating in religious activities benefits older adults’ mental health; however, the effects of grave visitation, a significant religious practice in Japan, on older adults’ mental health remain unclear. Therefore, this study examined the relationship between grave visitation frequency and depressive symptoms. Methods: A prospective cohort study of 273 community-dwelling older adults in Japan was conducted with baseline (2018) and follow-up (2022) assessments. Participants were categorized by visitation frequency: more or less than once a week. Changes in visitation frequency were classified as continued high, decreased, continued low, or increased. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Multivariable linear regressions were used to examine the association between visitation and depressive symptoms. Results: Lower visitation at baseline was associated with worse GDS-15 scores in the follow-up. Those with decreased or continued low visitation had significantly worse depressive symptoms. After adjusting for baseline GDS-15 scores and covariates, the decreased group had significantly worse depressive symptoms than the continued high group. Conclusions: The findings indicate that changes in grave visitation frequency are significantly associated with depressive symptoms. Clinical Implications: Supporting older adults’ access to grave visitation through transportation or community programs may help maintain their well-being and emotional health.

DOI： 10.1080/07317115.2025.2538105

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PubMed
Akaida S., Tabira T., Tateishi M., Shiratsuchi D., Shimokihara S., Kuratsu R., Akasaki Y., Hidaka Y., Makizako H. . Averting older adults' memory function decline via meaningful activities: a follow-up longitudinal study . European Geriatric Medicine15 ( 6 ) 1793 - 1801 2024.12

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Language：Japanese Publisher：European Geriatric Medicine

Purpose The purpose of the study was to investigate the effects of satisfaction with meaningful activities and their performance on the memory function among community-dwelling older adults 3 years later. Methods A longitudinal analysis was conducted on 288 community-dwelling older adults aged 65 years and more who had completed the survey in 2019 and 2022 as participants in the Tarumizu Study. Meaningful activities were assessed in 2019 using the Aid for Decision-Making in Occupation Choice for activities. Satisfaction with and performance of meaningful activities were assessed, and the bottom 25% were classified into two groups: low satisfaction and low performance. Memory function was assessed using the National Center for Geriatrics and Gerontology-Functional Assessment Tool in 2019 and 2022. Changes in memory function over 3 years were analyzed by satisfaction and performance of meaningful activities. Results Two-way analysis of variance with group (satisfaction with and performance of meaningful activities) and time (2019 and 2022) as factors showed no statistically significant group-time interaction for memory in the satisfaction with meaningful activities group (F = 1.4, p = 0.24). Meanwhile, a statistically significant group-time interaction was observed for memory in the meaningful activity performance group, indicating that high performance of meaningful activities may play a protective role against memory decline (F = 7.4, p = 0.007). Conclusion Higher performance of meaningful activities may protect against age-related changes in memory. A careful assessment of meaningful activities, and engagement that enhances performance may be useful in designing health support against memory decline.

DOI： 10.1007/s41999-024-01044-4

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PubMed
Akasaki Yuichi . Once-daily Extended-Release Pemafibrate Enhances Adherence and Triglyceride Control Over Twice-Daily Dosing . Journal of Atherosclerosis and Thrombosis31 ( 11 ) 1512 - 1514 2024.11

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Language：English Publisher：Japan Atherosclerosis Society

DOI： 10.5551/jat.ed266

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CiNii Research
Akasaki Y, Tabira T, Maruta M, Makizako H, Shimokihara S, Hidaka Y, Kamasaki T, Kukizako W, Kubozono T, Ohishi M . Subjective Memory Complaints Related to Satisfaction With Meaningful Activities Among Community-Dwelling Older Adults. . Cureus16 ( 11 ) e73433 2024.11

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Language：English

DOI： 10.7759/cureus.73433

PubMed
Miyata M, Kuroda M, Miyoshi J, Kirinashizawa M, Nagasawa R, Yamamoto M, Akasaki Y, Utatsu K, Maezawa Y, Yokote K, Ohishi M . Novel pathogenic variant in the LCAT gene in a compound heterozygous patient with fish-eye disease and a mild phenotype . J Clin Lipidol.　19 ( 1 ) 125 - 133 2024.10Reviewed

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DOI： 10.1016/j.jacl.2024.09.013
Miyata M, Kuroda M, Miyoshi J, Kirinashizawa M, Nagasawa R, Yamamoto M, Akasaki Y, Utatsu K, Maezawa Y, Yokote K, Ohishi M . Novel pathogenic variant in the LCAT gene in a compound heterozygous patient with fish-eye disease and a mild phenotype . J Clin Lipidol.19 ( 1 ) 125 - 133 2024.10Reviewed

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DOI： 10.1016/j.jacl.2024.09.013
赤崎雄一, 二宮雄一, 川添晋, 窪薗琢郎, 大石充 . 発表!!JSH2024禁煙宣言～すわん君も来るよ禁煙に伴う体重増加と血圧上昇について . 日本高血圧学会総会プログラム・抄録集46回 273 - 273 2024.10

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Language：Japanese Publisher：(NPO)日本高血圧学会
Sakima A, Akagi Y, Akasaki Y, Fujii T, Haze T, Kawakami-Mori F, Kitajima K, Kobayashi Y, Matayoshi T, Sakaguchi T, Yamazato M, Abe M, Ohya Y, Arima H . Effectiveness of digital health interventions for telemedicine/telehealth for managing blood pressure in adults: a systematic review and meta-analysis . Hypertens Res.48 ( 2 ) 478 - 491 2024.7Reviewed

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DOI： 10.1038/s41440-024-01792-7
Kubozono Takuro, Akasaki Yuichi, Kawasoe Shin, Ojima Satoko, Yamaguchi Satoshi, Kuwahata So, Takenaka Toshihiro, Maeda Mayuka, Fujiwara Seisuke, Ikeda Yoshiyuki, Ohishi Mitsuru . 排便状態と血圧および血圧変動性の関係(Relationship between defecation status and blood pressure level or blood pressure variability) . Hypertension Research47 ( 1 ) 128 - 136 2024.1

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Language：English Publisher：Nature Publishing Group

血圧日間変動と排便状況の関連について検討した。対象はコホート登録時と1年後に家庭血圧を月8日以上測定できた地域住民184名(女性110名、平均71±8歳)である。血圧の日間変動性の指標として1ヵ月間の家庭収縮期血圧の変動係数(CV)を算出した。毎日の排便の有無を自記式質問票で確認し、有りの場合を排便状況良好、無しの場合を不良とした。平均CV値は登録時5.93%、1年後5.88%であった。1年後にCVが上昇したのは89名で、その割合は排便状況良好群(61/145名、42%)に比べ、不良群(28/39名、72%)で高かった(P=0.001)。1年後のCV上昇を目的変数、年齢、性、排便状況、服薬状況(降圧剤、下剤、整腸剤)、登録時のCVを独立変数とする多変量回帰分析において、排便状況不良はCV上昇と独立した関連を示した(オッズ比3.81、95%CI 1.64～8.87、P=0.0019)。
Sakoda Takashi, Akasaki Yuichi, Sasaki Yuichi, Kawasoe Shin, Kubozono Takuro, Ikeda Yoshiyuki, Miyahara Hironori, Tokusige Koichi, Ohishi Mitsuru . トリグリセリド・グルコース指数は正常血圧および孤立性拡張期高血圧を含む全集団において将来の慢性腎臓病発症を予測する(Triglyceride-glucose index predicts future chronic kidney disease development in all populations, including normotensive and isolated diastolic hypertension) . Hypertension Research47 ( 1 ) 149 - 156 2024.1

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Language：English Publisher：Nature Publishing Group

インスリン抵抗性の指標であるトリグリセリド・グルコース指数(TyG)と慢性腎臓病(CKD)発症の関連について高血圧のサブタイプ別に検討した。年次健診を複数回受診した中年男性32818名を、血圧140/90mmHgをカットオフ値として孤立性拡張期高血圧(IDH、6.72%)、孤立性収縮期高血圧(ISH、7.06%)、収縮期・拡張期高血圧(SDH、10.05%)、正常血圧(76.17%)に群別した。追跡期間中央値6.78年で232名(10.51%)がCKDを発症した。TyGの1単位増加あたりのハザード比は、SDH(1.40、95%CI 1.19～1.64)>ISH(1.36、1.12～1.64)>IDH(1.31、1.06～1.62)>正常血圧(1.18、1.09～1.28)の順に高かった。中年男性のTyG高値は、高血圧の有無や分類にかかわらず、将来のCKD発症と関連することが示唆された。
Kubozono Takuro, Akasaki Yuichi, Kawasoe Shin, Ojima Satoko, Yamaguchi Satoshi, Kuwahata So, Takenaka Toshihiro, Maeda Mayuka, Fujiwara Seisuke, Ikeda Yoshiyuki, Ohishi Mitsuru . 排便状態と血圧および血圧変動性の関係(Relationship between defecation status and blood pressure level or blood pressure variability) . Hypertension Research47 ( 1 ) 128 - 136 2024.1

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Language：English Publisher：Nature Publishing Group

血圧日間変動と排便状況の関連について検討した。対象はコホート登録時と1年後に家庭血圧を月8日以上測定できた地域住民184名(女性110名、平均71±8歳)である。血圧の日間変動性の指標として1ヵ月間の家庭収縮期血圧の変動係数(CV)を算出した。毎日の排便の有無を自記式質問票で確認し、有りの場合を排便状況良好、無しの場合を不良とした。平均CV値は登録時5.93%、1年後5.88%であった。1年後にCVが上昇したのは89名で、その割合は排便状況良好群(61/145名、42%)に比べ、不良群(28/39名、72%)で高かった(P=0.001)。1年後のCV上昇を目的変数、年齢、性、排便状況、服薬状況(降圧剤、下剤、整腸剤)、登録時のCVを独立変数とする多変量回帰分析において、排便状況不良はCV上昇と独立した関連を示した(オッズ比3.81、95%CI 1.64～8.87、P=0.0019)。
Sakoda Takashi, Akasaki Yuichi, Sasaki Yuichi, Kawasoe Shin, Kubozono Takuro, Ikeda Yoshiyuki, Miyahara Hironori, Tokusige Koichi, Ohishi Mitsuru . トリグリセリド・グルコース指数は正常血圧および孤立性拡張期高血圧を含む全集団において将来の慢性腎臓病発症を予測する(Triglyceride-glucose index predicts future chronic kidney disease development in all populations, including normotensive and isolated diastolic hypertension) . Hypertension Research47 ( 1 ) 149 - 156 2024.1

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Language：English Publisher：Nature Publishing Group

インスリン抵抗性の指標であるトリグリセリド・グルコース指数(TyG)と慢性腎臓病(CKD)発症の関連について高血圧のサブタイプ別に検討した。年次健診を複数回受診した中年男性32818名を、血圧140/90mmHgをカットオフ値として孤立性拡張期高血圧(IDH、6.72%)、孤立性収縮期高血圧(ISH、7.06%)、収縮期・拡張期高血圧(SDH、10.05%)、正常血圧(76.17%)に群別した。追跡期間中央値6.78年で232名(10.51%)がCKDを発症した。TyGの1単位増加あたりのハザード比は、SDH(1.40、95%CI 1.19～1.64)>ISH(1.36、1.12～1.64)>IDH(1.31、1.06～1.62)>正常血圧(1.18、1.09～1.28)の順に高かった。中年男性のTyG高値は、高血圧の有無や分類にかかわらず、将来のCKD発症と関連することが示唆された。
Saito Y., Tanaka A., Imai T., Nakamura I., Kanda J., Matsuhisa M., Uehara H., Kario K., Kobayashi Y., Node K., Nishio K., Kurozumi A., Suzuki S., Sugimoto K., Doi M., Minami H., Furuta M., Narisawa M., Umikawa M., Miyazaki M., Koikawa K., Uemura F., Otsuka T., Tokutsu A., Sonoda S., Tanaka K., Okada Y., Fukumoto K., Shuto T., Yoshiyama M., Takemoto Y., Wakami K., Sugiura T., Ohte N., Kodama K., Nakano J., Arimura T., Sugihara M., Mirii J., Shiga Y., Miura S.I., Kondo T., Okumura T., Bando Y., Morimoto R., Machii N., Kudo A., Yasuda K., Izumi K., Takahara K., Ohguchi S., Oguri M., Sakamoto Y., Kanbara T., Osanai H., Nakashima Y., Asano H., Ajioka M., Abe M., Gima Y., Hatano S., Chiba S., Nago C., Nakamura K., Chinen T., Miyagi N., Koyosue A., Kanzaki Y., Sohmiya K., Hoshiga M., Matsunaga K., Nakamura R., Kadokami T., Hisauchi I., Hirose M., Hayashi T., Takenaka M., Maeda M., Ogura Y., Suzuki H., Yoshida Y., Yoshida R., Uchimura Y., Oshita C., Orita Y., Takase B., Hironori K., Kuriyama N., Shibata Y., Kubota Y., Maruhashi T., Kajikawa M., Kishimoto S., Higashi Y., Koga S., Fukae S., Ikeda S. . Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial . Hypertension Research47 ( 1 ) 168 - 176 2024.1

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Language：Japanese Publisher：Hypertension Research

Although previous reports have shown that sodium-glucose cotransporter-2 (SGLT2) inhibitors have a blood pressure (BP) lowering effect, relevant long-term data is limited. This study aimed to evaluate the effect of the SGLT2 inhibitor ipragliflozin on BP, and associations between BP reduction and changes in cardiometabolic variables in diabetic patients. This was a sub-analysis of the PROTECT trial, a multicenter, randomized, open-label study to assess if ipragliflozin delays carotid atherosclerosis in patients with type 2 diabetes. Participants were randomized to ipragliflozin and control groups. The primary endpoint of the present sub-analysis was the trajectory of systolic BP over 24 months. Correlations between systolic BP changes and cardiometabolic variables were also evaluated. A total of 232 eligible participants with well-balanced baseline characteristics were included in each study group. Throughout the 24-month study period, mean systolic BP was lower in the ipragliflozin group. At 24 months, a between-group difference (ipragliflozin minus control) in mean systolic BP change from baseline was −3.6 mmHg (95% confidence interval, −6.2 to −1.0 mmHg), and the reduction in systolic BP in the ipragliflozin group was consistent across subgroups examined. Changes in systolic BP significantly correlated with those in body mass index in the ipragliflozin group, while no significant correlations with other cardiometabolic variables tested were observed. In conclusion, ipragliflozin treatment was associated with BP reduction throughout the 24-month follow-up period as compared to control treatment. BP reduction correlated with weight loss, which might be one of the mechanisms for the BP lowering effect of SGLT2 inhibitors. (Figure presented.)

DOI： 10.1038/s41440-023-01494-6

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Yatsushiro R., Matsuda F., Causer B., Inoue K., Kikata J., Miura N., Hashimoto K., Akasaki Y., Unedaya K. . Using virtual fieldwork to support interprofessional and community-based learning: students from four faculties investigate life on a remote island in Japan . Frontiers in Education9 2024

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Language：Japanese Publisher：Frontiers in Education

Introduction: The Mishima Islands in Kagoshima Prefecture, Japan, are remote islands designated as medically underserved. Supporting the people living in such remote islands requires a multifaceted examination of the livelihoods of the residents, including their health, work, and living environment. Methods: Students from the faculties of nursing, veterinary science, agriculture, and engineering participated in a 3-day virtual fieldwork session held synchronously from the campus of Kagoshima University and on a remote island in the Mishima Mura island group in Kagoshima Prefecture, Japan. Coursework and post-course surveys were analyzed to determine student engagement and learning. In particular, the analysis considered learning in relation to interprofessional learning and community-based learning. Results and discussion: Students expressed being able to conduct fieldwork online, collaborate with students from multiple faculties and graduate schools, and apply their expertise. These outcomes were reflected in the five-point Likert scale evaluation responses, highlighting a sense of accomplishment and satisfaction. Virtual fieldwork can contribute to student learning by introducing new concepts and allowing them to consider development issues in remote areas from multiple perspectives.

DOI： 10.3389/feduc.2024.1421218

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Kamasaki T., Otao H., Hachiya M., Tanaka S., Ochishi K., Shimokihara S., Maruta M., Han G., Akasaki Y., Hidaka Y., Tabira T. . Association between Toe Pressure Strength in the Standing Position and Maximum Walking Speed in Older Adults . Annals of Geriatric Medicine and Research27 ( 4 ) 338 - 345 2023.12

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Language：Japanese Publisher：Annals of Geriatric Medicine and Research

Background: Considering concerns about conventional toe grip strength, we devised a method to measure toe pressure strength in the standing position, which is close to the actual motion. This study examined the association between toe pressure strength in the standing position and walking speed among older adults. Methods: This cross-sectional study included 150 communi-ty-dwelling older adults (81±8 years, 73% female) who participated in the physical fitness test. We analyzed the correlation between the participants’ maximum walking speed and physical function. Furthermore, we performed regression analysis with the maximum walking speed as the dependent variable to examine the association with toe pressure strength in the standing position. We also examined the association between maximum walking speed and toe pressure strength in the standing position by introducing a covariate. Results: Correlation analysis revealed a significant positive correlation between maximum walking speed and toe pressure strength in the standing position, with a moderate effect size (r=0.48, p<0.001). Moreover, multiple regression analysis with covariates showed an association between maximum walking speed and toe pressure strength in the standing position (standardization factor=0.13, p<0.026). Conclusion: Toe pressure strength in the standing position was associated with maximum walking speed. This finding clari-fies the significance of assessing toe pressure strength in the standing position and suggests that enhanced toe pressure strength in the standing position may increase maximum walking speed.

DOI： 10.4235/agmr.23.0113

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PubMed
Saito Y., Tanaka A., Ishizu T., Yoshida H., Kubota Y., Nanasato M., Matsuhisa M., Ohya Y., Kobayashi Y., Node K., Murohara T., Inoue T., Sata M., Ohishi M., Yokote K., Kario K., Watada H., Shimomura I., Fukumoto Y., Maemura K., Akasaki Y., Ako J., Amano H., Aonuma K., Aoyama Y., Arai H., Asai K., Asaka M., Awaji Y., Ban N., Ban T., Bando Y.K., Daida H., Eguchi S., Enomoto M., Fujii Y., Fujikake A., Fujimoto M., Fujisaka T., Fujita S., Fukae S., Fukuda D., Fukui M., Goriki Y., Hamasaki S., Hara T., Hasegawa H., Hashimoto K., Hata M., Hata S., Hayashida R., Higashi A., Higuchi S., Honda A., Hoshide S., Hoshiga M., Hotchi J., Igata S., Ikehara Y., Inoue Y., Ishigami H., Ishihara M., Ishii H., Ishikawa T., Ishimatsu T., Ishiyama Y., Ito T., Ito A., Kadokami T., Kamiya H., Kashihara S., Kawamura Y., Kitagawa K., Kodera S., Koga S., Koide H., Koide Y., Koiwaya H., Kojima H., Komai E., Komatsu T., Kono S., Kono T., Kuroda A., Kuroyanagi T., Kushiyama A., Kusunose K., Maruhashi T., Matsunaga K., Matsuura T., Mayama T., Mine D., Miyamura M., Morimoto R., Morita H. . Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study . Scientific Reports13 ( 1 ) 2023.12

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Language：Japanese Publisher：Scientific Reports

Hyperuricemia is reportedly associated with the progression of carotid intima-media thickness (IMT), a surrogate of cardiovascular risks and events. However, factors associated with carotid IMT progression in patients with asymptomatic hyperuricemia are largely unknown. In this post-hoc analysis of the multicenter, randomized PRIZE study, we analyzed data from a total of 326 patients who underwent carotid ultrasonography in a blind manner at baseline and 24 months to evaluate carotid IMT. Mean and maximum IMT at the common carotid artery (CCA) were measured at a central core laboratory. Factors related to the absolute change in mean and maximum IMT from baseline to 24 months were explored. Overall, the adjusted mean [0.0032 (− 0.0214 to 0.0278) mm] and maximum [0.0011 (− 0.0327 to 0.0351) mm] CCA-IMT increased numerically from baseline to 24 months. Multivariable analysis identified higher body mass index, history of atherosclerotic cardiovascular disease (ASCVD), and lower mean CCA-IMT at baseline as significant factors associated with the increase in mean CCA-IMT. In addition, older age and lower mean CCA-IMT at baseline were significant factors for an increased absolute change in the maximum CCA-IMT at 24 months. The present sub-analysis of the PRIZE study showed higher body mass index, history of ASCVD, and older age as significant factors associated with CCA-IMT progression in patients with asymptomatic hyperuricemia. These factors may be considered when identifying the possible risk of atherosclerotic progression in this specific patient population of hyperuricemia. Trial registration: UMIN000012911 and UMIN000041322.

DOI： 10.1038/s41598-023-37183-0

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Sakoda T, Akasaki Y, Sasaki Y, Kawasoe S, Kubozono T, Ikeda Y, Miyahara H, Tokusige K, Ohishi M . Triglyceride-glucose index predicts future chronic kidney disease development in all populations, including normotensive and isolated diastolic hypertension . Hypertens Res.47 ( 1 ) 149 - 156 2023.11Reviewed

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DOI： 10.1038/s41440-023-01507-4
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Yamaguchi S, Kuwahata S, Takenaka T, Maeda M, Fujiwara S, Ikeda Y, Ohishi M . Relationship between defecation status and blood pressure level or blood pressure variability . Hypertens Res.47 ( 1 ) 128 - 136 2023.9Reviewed

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DOI： 10.1038/s41440-023-01435-3
Akasaki Yuichi, Ohishi Mitsuru . 【アジアでの高血圧管理における現在のエビデンスと展望】高齢者の認知機能を維持するためには高血圧症および脂質異常症をどう管理すべきか(【Current evidence and perspectives for hypertension management in Asia】How should we manage hypertension and dyslipidemia to maintain cognitive function in older adults?) . Hypertension Research46 ( 8 ) 1880 - 1882 2023.8

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Akasaki Yuichi, Ohishi Mitsuru . 【アジアでの高血圧管理における現在のエビデンスと展望】高齢者の認知機能を維持するためには高血圧症および脂質異常症をどう管理すべきか(【Current evidence and perspectives for hypertension management in Asia】How should we manage hypertension and dyslipidemia to maintain cognitive function in older adults?) . Hypertension Research46 ( 8 ) 1880 - 1882 2023.8

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Kamasaki T., Tabira T., Suenaga T., Yoshida T., Shimokihara S., Maruta M., Han G., Akasaki Y., Hidaka Y., Otao H. . Association between toe pressure strength in the standing position and postural control capability in healthy adults . Gait and Posture103 86 - 91 2023.6

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Background: A method has been developed to assess toe pressure strength in the standing position, taking into account concerns about toe grip strength. Research question: Which is more associated to postural control capability, the conventional toe grip strength or the newly devised toe pressure strength in the standing position, which is close to the actual movement? Methods: This study is a cross-sectional study. This study included 67 healthy adults (mean age, 19 ± 1 years; 64% male). The postural control capability was measured using the center-of-pressure shift distance in the anterior–posterior axis. Toe pressure strength in the standing position was assessed using a toe pressure measuring device to evaluate the force of pressure on the floor surface by all toes. During measurement, care is taken to ensure that the toes do not flex. However, toe grip strength in the sitting position was measured using muscle strength for toe flexion in a conventional manner. Statistical analysis was conducted by performing a correlation analysis between each of the measured items. Additionally, multiple regression analysis was used to examine the functions associated with postural control capability. Result: Pearson's correlation analysis revealed that the postural control capability was correlated with toe pressure strength in the standing position (r = 0.36, p = 0.003). Multiple regression analysis demonstrated that only toe pressure strength in the standing position was significantly associated with the postural control capability, even after adjusting for covariates (standard regression coefficient: 0.42, p = 0.005). Significance: The results of this study indicated that toe pressure strength in the standing position was more strongly associated with the postural control capability in healthy adults than toe grip strength in the sitting position. It has been suggested that a rehabilitation program for toe pressure strength in the standing position would help improve postural control capability.

DOI： 10.1016/j.gaitpost.2023.04.015

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Maruta M., Tabira T., Shimokihara S., Makizako H., Ikeda Y., Han G., Akasaki Y., Hidaka Y., Nakahara R., Kamasaki T., Kukizaki W., Kubozono T., Ohishi M. . Changes in Satisfaction with Meaningful Activities and Onset of Depressive Symptoms among Community-Dwelling Japanese Older Adults: A Population-Based Study Before and During the COVID-19 Pandemic . Journal of the American Medical Directors Association24 ( 5 ) 702 - 709.e3 2023.5

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Objectives: This study aimed to clarify the association between changes in satisfaction with meaningful activities and the occurrence of depressive symptoms before and during the coronavirus disease 2019 (COVID-19) pandemic. Design: A population-based prospective cohort study (Tarumizu Study). Setting and Participants: A total of 231 community-dwelling older adults aged ≥65 years without depressive symptoms at baseline. Methods: The participants completed baseline (June to December 2018, before the COVID-19 pandemic) and follow-up (September to December 2021, during the COVID-19 pandemic) assessments. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale (GDS-15) and defined by a GDS-15 score of ≥5. Participants selected meaningful activities from the 95 activities included in the Aid for Decision-Making in Occupation Choice, and their satisfaction levels were evaluated. Satisfaction with the most meaningful activities was assessed as to whether it was maintained/improved or decreased at follow-up. Results: In the follow-up survey, 31 (14.3%) participants reported the occurrence of depressive symptoms. Compared with before the COVID-19 pandemic, the rates of meaningful activities during the COVID-19 pandemic decreased for interpersonal interaction and social life and increased for leisure, sports, self-care, and domestic life. Logistic regression analysis revealed that changes in satisfaction with meaningful activity were associated with the occurrence of depressive symptoms after adjusting for demographic variables, baseline GDS scores, cognitive and physical status, and instrumental activities of daily living (odds ratio, 2.78; 95% confidence interval, 1.17–6.59, P = .020). Conclusions and Implications: To avoid decreasing satisfaction with meaningful activities, supporting older adults may be protective against the occurrence of depressive symptoms. Our findings highlight the need for health care professionals to not only encourage older adults to participate in activities for their mental health but also consider whether the activities are meaningful or satisfying for them.

DOI： 10.1016/j.jamda.2023.03.010

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Hidaka Y., Tabira T., Maruta M., Makizako H., Ikeda Y., Nakamura A., Han G., Miyata H., Shimokihara S., Akasaki Y., Kamasaki T., Kubozono T., Ohishi M. . Relationship between grave visitation and apathy among community-dwelling older adults . Psychogeriatrics23 ( 3 ) 401 - 410 2023.5

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Background: It has been shown that involvement in religious activities has a positive impact on psychological aspects. In this study, the relationship between grave visitation, a standard religious activity in Japan, and depression and apathy symptoms was investigated among older adults in Japan. Methods: A total of 638 older adults who participated in a community-based health check survey (Tarumizu Study 2019) were interviewed regarding the presence or absence of grave visitation, frequency, travel time, means of transportation, and flower offerings. Apathy and depressive symptoms were measured using the 15-item Geriatric Depression Scale (GDS-15). The participants were categorised into three grave visitation groups, namely, frequent (more than once per week), occasional (less than once per week), and non-visiting. Outcomes were compared between the frequency groups, and Poisson regression analysis was used to investigate the relationship between grave visitation frequency and apathy and depression. Results: Of the participants, 91.8% reported regular grave visitation. The non-visiting group had a significantly higher prevalence of apathy symptoms (44.2%) than the visiting groups. Furthermore, using the frequent group as the reference, Poisson regression analysis adjusted for potential covariates demonstrated that no grave visitation was significantly related to apathy (prevalence ratio, 1.43; 95% confidence interval, 1.00–2.05, P = 0.049). Conclusions: Not practising grave visitation was significantly related to apathy among older adults. Helping older adults to visit graves may prevent apathy by facilitating motivation and increasing activity.

DOI： 10.1111/psyg.12945

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Maruta M., Shimokihara S., Akasaki Y., Hidaka Y., Ikeda Y., Han G., Tanaka G., Higashi T., Moriuchi T., Tabira T. . Associations between Optimism and Attentional Biases as Measured by Threat-Avoidance and Positive-Search Tasks . Healthcare Switzerland11 ( 4 ) 2023.2

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Evidence suggests that optimism has a positive impact on health status. Attentional bias modification (ABM) may be beneficial for enhancing optimism, but its effective application requires a detailed investigation of the association between attentional bias and optimism. This study aimed to determine the association between attentional bias and optimism based on different task types. Eighty-four participants completed the attentional bias measures using the dot-probe task (DPT), emotional visual search task (EVST) paradigms, and psychological assessments. Optimism was assessed using the Life Orientation Test-Revised with subscales for optimism and pessimism. Pearson’s correlation coefficient and multivariate linear regression analysis were applied to investigate the association between optimism and attentional bias. Neither the attentional bias derived from DPT nor EVST was significantly correlated with optimism total score or subscales. Regression analysis also showed no association between attentional bias and optimism (DPT, β = 0.12; EVST, β = 0.09), optimism subscales (DPT, β = 0.09; EVST, β = 0.17), or pessimism subscales (DPT, β = −0.10; EVST, β = 0.02). Our findings showed no evidence that attentional biases derived from either the DPT or EVST measures are associated with optimism or pessimism. Further studies are needed to effectively adapt the ABM to enhance optimism.

DOI： 10.3390/healthcare11040617

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Shimokihara S., Maruta M., Han G., Ikeda Y., Kamasaki T., Hidaka Y., Akasaki Y., Tabira T. . Real-World Navigation With Application: Characteristics of Gaze Behavior and Associated Factors in Older Adults . Innovation in Aging7 ( 8 ) igad108 2023

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Background and Objectives: Advancing age might impair real-world navigation ability. The use of mobile devices by older adults has grown rapidly in recent years. Navigation applications (apps) in mobile devices may facilitate the freedom of outings for older adults. Our aim is to investigate age-related differences in real-world app-based navigation walking in terms of accuracy, efficiency, and gaze behavior; and to explore clinical factors associated with navigation walking in older adults. Research Design and Methods: A total of 20 community-dwelling older adults and 16 young adults completed a route navigation task using a navigation app while recording their gaze behavior. Outcomes were compared in both groups and a general linear regression was used to explore clinical factors associated with app-based navigation walk in older adults. Results: Compared with young participants, older participants had more stops and root errors and less fixation time, smaller amplitude of saccades. Additionally, older adults were more likely to glance at their smartphones while app-based navigation walking. Furthermore, gait speed and the following assessment scores were significantly associated with navigation walking in older adults: Mini-Mental State Examination, Life-Space Assessment, and the short version of the Mobile Device Proficiency Questionnaire. Discussion and Implications: For app-based navigation walks, differences in accuracy and gaze behavior were found to exist with age. Additionally, efficient real-world navigation walks in older adults require the extent of life space and proficiency with mobile devices, along with walking speed and cognitive function. It is possible that age-related functional decline, such as the visual field and shifting attention between mobile devices and the real world, may have influenced the results. The study also suggests the need to understand the level of proficiency with mobile devices so that older adults can continue to go out freely. These findings give the basis for providing older adults with appropriate navigation assistance. Translational Significance: Real-world navigation ability is known to decline with age. Many older adults are now using mobile devices, but little is known about their accuracy and gaze behavior while using navigation applications. Our study revealed that older participants exhibited more stops and errors, smaller saccade angles and fixation durations, and glanced at smartphones more frequently than younger participants during navigation tasks. Efficient navigation was associated not only with cognitive and physical function but also with life space and mobile device proficiency. Our findings provide valuable insights for enhancing the use of technology by older adults and improving their navigation in the real world.

DOI： 10.1093/geroni/igad108

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Kawabata T, Kubozono T, Ojima S, Kawasoe S, Akasaki Y, Salim AA, Ikeda Y, Miyata M, Takenaka T, Ohishi M. . Insufficient blood pressure control is independently associated with increased arterial stiffness . Hypertens Res.45 ( 12 ) 1861 - 1868 2022.12
Kawabata T., Kubozono T., Ojima S., Kawasoe S., Akasaki Y., Salim AA, Ikeda Y., Miyata M., Takenaka T., Ohishi M. . Insufficient blood pressure control is independently associated with increased arterial stiffness . Hypertens Res.45 ( 12 ) 1861 - 1868 2022.12
Kawabata Takeko, Kubozono Takuro, Ojima Satoko, Kawasoe Shin, Akasaki Yuichi, Salim Anwar Ahmed, Ikeda Yoshiyuki, Miyata Masaaki, Takenaka Toshihiro, Ohishi Mitsuru . 【アジアにおける高血圧管理の現状と展望】不十分な血圧コントロールは動脈スティフネス増大と独立して関連する(【Current evidence and perspectives for hypertension management in Asia】Insufficient blood pressure control is independently associated with increased arterial stiffness) . Hypertension Research45 ( 12 ) 1861 - 1868 2022.12

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垂水市で行われた地域住民を対象とするコホート研究に参加した980名を対象に、降圧薬を用いた場合と用いない場合の血圧コントロール状況と動脈スティフネスとの関連性を評価した。動脈スティフネスの評価には心臓足首血管指数(CAVI)を用いた。高血圧の定義は、収縮期血圧140mmHg以上または拡張期血圧90mmHg以上とした。未治療コントロール良好群421名(平均64±11歳)、未治療コントロール不良群174名(平均67±11歳)、治療コントロール良好群209名(平均73±9歳)、治療コントロール不良群176名(平均73±9歳)に分類した。CAVI評価時の年齢、性別、脂質異常症治療薬使用、糖尿病治療薬使用、肥満、喫煙、飲酒、心拍数を調整後、CAVI高値のカットオフ値を8.0とした場合は未治療コントロール良好群に比べて他の3群でCAVIが有意に高値であり、カットオフ値を9.0とした場合は治療コントロール不良群と未治療コントロール不良群でCAVIが有意に高値であった。降圧薬治療を行っても、血圧コントロール不良はCAVI高値と独立して関連することが示された。
Kawabata Takeko, Kubozono Takuro, Ojima Satoko, Kawasoe Shin, Akasaki Yuichi, Salim Anwar Ahmed, Ikeda Yoshiyuki, Miyata Masaaki, Takenaka Toshihiro, Ohishi Mitsuru . 【アジアにおける高血圧管理の現状と展望】不十分な血圧コントロールは動脈スティフネス増大と独立して関連する(【Current evidence and perspectives for hypertension management in Asia】Insufficient blood pressure control is independently associated with increased arterial stiffness) . Hypertension Research45 ( 12 ) 1861 - 1868 2022.12

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Language：English Publisher：Nature Publishing Group

垂水市で行われた地域住民を対象とするコホート研究に参加した980名を対象に、降圧薬を用いた場合と用いない場合の血圧コントロール状況と動脈スティフネスとの関連性を評価した。動脈スティフネスの評価には心臓足首血管指数(CAVI)を用いた。高血圧の定義は、収縮期血圧140mmHg以上または拡張期血圧90mmHg以上とした。未治療コントロール良好群421名(平均64±11歳)、未治療コントロール不良群174名(平均67±11歳)、治療コントロール良好群209名(平均73±9歳)、治療コントロール不良群176名(平均73±9歳)に分類した。CAVI評価時の年齢、性別、脂質異常症治療薬使用、糖尿病治療薬使用、肥満、喫煙、飲酒、心拍数を調整後、CAVI高値のカットオフ値を8.0とした場合は未治療コントロール良好群に比べて他の3群でCAVIが有意に高値であり、カットオフ値を9.0とした場合は治療コントロール不良群と未治療コントロール不良群でCAVIが有意に高値であった。降圧薬治療を行っても、血圧コントロール不良はCAVI高値と独立して関連することが示された。
Kawabata T., Kubozono T., Ojima S., Kawasoe S., Akasaki Y., Salim A.A., Ikeda Y., Miyata M., Takenaka T., Ohishi M. . Insufficient blood pressure control is independently associated with increased arterial stiffness . Hypertension Research45 ( 12 ) 1861 - 1868 2022.12

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Language：Japanese Publisher：Hypertension Research

Hypertension is a risk factor for atherosclerosis. Achieving the therapeutic target value of blood pressure (BP) prevents the onset of cardiovascular events; however, it is not clear how antihypertensive drug use and BP control status relate to arterial stiffness. The purpose of this study is to investigate the relationship between BP control status with or without antihypertensive drugs and arterial stiffness. Nine hundred eighty individuals (mean age: 68 ± 11 years) who participated in a community-based cohort study were enrolled. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI). Higher BP was defined as a systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg. Participants were divided into four groups: normal, non higher BP without antihypertensive drugs (n = 421); untreated, higher BP without antihypertensive drugs (n = 174); good control, non higher BP with antihypertensive drugs (n = 209); and poor control, higher BP with antihypertensive drugs (n = 176). In multivariable logistic analysis adjusted for age, sex, dyslipidemia and diabetes mellitus medication use, obesity, smoking, alcohol drinking, and heart rate at the CAVI measurement for a high CAVI—using a borderline cutoff value of 8.0—the other three groups were significantly associated with a high CAVI when compared with the normal group. By contrast, multivariable logistic analysis of a high CAVI using an abnormal cutoff value of 9.0 demonstrated that the poor control and untreated groups were significantly associated with a high CAVI, whereas the good control group was not. In conclusion, even with antihypertensive drugs, poor BP control is independently associated with a high CAVI.

DOI： 10.1038/s41440-022-01039-3

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Akasaki Y, Tabira T, Maruta M, Makizako H, Miyata M, Han G, Ikeda Y, Nakamura A, Shimokihara S, Hidaka Y, Kamasaki T, Kubozono T, Ohishi M. . Social frailty and meaningful activities among community-dwelling older adults with heart disease . Int J Environ Res Public Health19 ( 22 ) 15167 2022.11Reviewed
Akasaki Y., Tabira T., Maruta M., Makizako H., Miyata M., Han G., Ikeda Y., Nakamura A., Shimokihara S., Hidaka Y., Kamasaki T., Kubozono T., Ohishi M. . Social frailty and meaningful activities among community-dwelling older adults with heart disease . Int J Environ Res Public Health19 ( 22 ) 15167 2022.11Reviewed
Akasaki Y., Tabira T., Maruta M., Makizako H., Miyata M., Han G., Ikeda Y., Nakamura A., Shimokihara S., Hidaka Y., Kamasaki T., Kubozono T., Ohishi M. . Social Frailty and Meaningful Activities among Community-Dwelling Older Adults with Heart Disease . International Journal of Environmental Research and Public Health19 ( 22 ) 2022.11

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Patients with heart disease are more likely to experience social frailty due to physical inactivity, which may affect meaningful activities such as hobbies. This study aimed to investigate (1) the association between heart disease and social frailty in community-dwelling older adults and (2) the characteristics of meaningful activities in community-dwelling older adults with heart disease. Data from 630 older adults who participated in a community-based health survey were obtained, including clinical history, meaningful activities, social frailty and psychosomatic functions. Participants were divided into two groups: those with heart disease (n = 79) and those without (n = 551), and comparisons were made. Social frailty was observed in 23.7% of participants with heart disease, and logistic regression revealed significant associations with heart disease and social frailty after adjusting for potential covariates (OR, 1.97; 95% CI, 1.06 3.67; p = 0.032). Participants with heart disease did not differ significantly in terms of satisfaction or performance; their frequency of engagement in meaningful activities was significantly lower than without heart disease (p = 0.041). These results suggest that heart disease and social frailty are associated in community-dwelling older adults, and that this demographic is inclined to engage in meaningful activities less frequently.

DOI： 10.3390/ijerph192215167

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Maruta M., Shimokihara S., Makizako H., Ikeda Y., Han G., Akasaki Y., Hidaka Y., Kamasaki T., Kubozono T., Ohishi M., Tabira T. . Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community-dwelling Japanese older adults . Psychogeriatrics22 ( 5 ) 651 - 658 2022.9

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Background: Frailty is a multidimensional condition characterised by reduced physical and psychological resilience. Older adults also frequently demonstrate apathy, suggesting that it shares similar neuro-physiological pathways with frailty. This cross-sectional study aimed to investigate the association between apathy and frailty as defined by a comprehensive assessment. Methods: We analyzed 882 older adults (mean age: 74.4 ± 6.4 years; 62.1% female) who participated in a community-based health check survey (Tarumizu Study). Apathy was measured by the Geriatric Depression Scale-3A, a three-item subset of the Geriatric Depression Scale-15, and frailty by the Kihon Checklist of physical, psychological, functional, and social status. Associations were examined by multinomial logistic regression with frailty status (robust, pre-frailty, frailty) as the dependent variable, apathy as the independent variable, and sociodemographic factors, medications, cognitive function, functional capacity, and mood symptoms as potential confounders. Results: Apathy was observed in 23.7% of individuals, and logistic regression revealed significant associations with both pre-frailty and frailty after confounder adjustment (pre-frailty: odds ratio (OR) 1.80, 95% CI 1.22–2.64; frailty: OR 3.24, 95% CI 1.63–6.42). Participants with apathy also exhibited greater deficits in the Kihon Checklist subdomains instrumental activities of daily living (P = 0.022), physical function (P < 0.001), oral function (P < 0.001), and cognitive function (P = 0.001). Conclusions: Our findings underscore the importance of comprehensive frailty assessment and demonstrate that apathy can have pervasive deleterious effects on geriatric health.

DOI： 10.1111/psyg.12867

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Miyata H., Maruta M., Makizako H., Han G., Ikeda Y., Nakamura A., Tokuda K., Shimokihara S., Akaida S., Hidaka Y., Akasaki Y., Kubozono T., Ohishi M., Tabira T. . Association between satisfaction with meaningful activities and social frailty in community-dwelling Japanese older adults . Archives of Gerontology and Geriatrics100 104665 2022.5

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Language：Japanese Publisher：Archives of Gerontology and Geriatrics

Objectives: This cross-sectional study investigates the associations among satisfaction with meaningful activities, and social frailty in community-dwelling Japanese older adults. Methods: We analyzed data from 596 older adults (mean age 74.2 ± 6.4 years, female 63.6%) who participated in the Tarumizu Study 2019, a community-based health survey. Participants selected meaningful activities from 95 activities using the Aid for Decision-Making in Occupation Choice (ADOC) tool. Satisfaction was evaluated from 1 to 5, and those who were assigned a rating of 4 or 5 were operationally classified as the high satisfaction group (n = 487), with others occupying the low satisfaction group (n = 109). Both groups were evaluated based on the ADOC, social frailty (Makizako's five items), physical function, depressive symptoms, cognitive function, and higher-level competence. Results: Of the 596 participants, 18.7% showed prevalence of social frailty. The low satisfaction group had a significantly higher prevalence of social frailty (low satisfaction 28.4% vs. high satisfaction 16.4%, P = 0.004) and depressive symptoms (low satisfaction 30.3% vs. high satisfaction 17.9%, P<0.01), and poor higher-level competence (P = 0.026) than the high satisfaction group. Logistic regression analysis showed that social frailty (Odds Ratio 1.78, 95% Confidence Interval 1.068–2.990, P = 0.027) was significantly associated with satisfaction with meaningful activity after adjusting for covariates. We found no significant differences in categories of meaningful activities between the low and high satisfaction groups (P = 0.549). Conclusions: This study suggested that social frailty was associated with satisfaction with meaningful activities, regardless of the degree or category of satisfaction.

DOI： 10.1016/j.archger.2022.104665

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Hiroaki Kanouchi, Mikako Yamashita, Kaori Kaimoto, Akiko Kuwabara, Yukiko Kawakami, Shigeo Takenaka, Chihaya Koriyama, So Kuwahata, Toshihiro Takenaka, Yuichi Akasaki, Takuro Kubozono, Masaaki Miyata, Mitsuru Ohishi . Association of blood pressure and dietary intake of Sunomono, Japanese vinegared side dishes, in community-dwelling Japanese: A cross-sectional study. . Heliyon8 ( 5 ) e09505 2022.5International journal

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Objective: Vinegar has been reported to have a hypotensive effect. We aimed to investigate the relationship between the consumption of vinegar-based side dishes and blood pressure. Research methods & procedures: This cross-sectional study included 746 individuals (257 men and 489 women) aged ≥40 years from Tarumizu, Kagoshima, Japan. Nutrient intake was estimated based on the brief-type self-administered diet history questionnaire. The intake frequency of vinegar-based side dishes (Sunomono and pickles) was determined using a self-administered diet history questionnaire. Participants who did not consume vinegar-based side dishes for a month were defined as having no Sunomono or pickle eating habit. Blood pressure was categorized into four groups according to the Japanese Society of Hypertension Guidelines for the Management of Hypertension. The association between the intake of vinegar-based side dishes and blood pressure categories was analyzed using ordinal logistic regression analysis adjusted for age, body mass index, smoking history, excessive alcohol intake, living situation, energy intake, protein intake, sodium intake, potassium intake, and seaweed intake. Results: Approximately 13.6% men and 6.1% women had no Sunomono eating habits. In men, eating Sunomono, but not pickles, was significantly related to blood pressure categories (estimate, -0.702; 95% CI, -1.122 to -0.310), whereas more frequent consumption of Sunomono did not show an improvement in the blood pressure category. The relationship between eating Sunomono and blood pressure categories was not recognized in women. Conclusion: This was the first study assessing the association between consumption of vinegar-based side dishes and blood pressure categories. We highlighted the effect of Sunomono consumption on blood pressure categories in men. Consumption of Sunomono may improve blood pressure in men.

DOI： 10.1016/j.heliyon.2022.e09505

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Yamamoto Koichi, Akasaka Hiroshi, Yasunobe Yukiko, Shimizu Atsuya, Nomoto Kenichiro, Nagai Kumiko, Umegaki Hiroyuki, Akasaki Yuichi, Kojima Taro, Kozaki Koichi, Kuzuya Masafumi, Ohishi Mitsuru, Akishita Masahiro, Takami Yoichi, Rakugi Hiromi, Cherry Study Group . 【アジアにおける高血圧管理の現在のエビデンスと展望】認知機能障害が認められない高血圧症高齢者の臨床的特徴(【Current evidence and perspectives for hypertension management in Asia】Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment) . Hypertension Research45 ( 4 ) 612 - 619 2022.4

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当院外来を受診した65歳以上の高血圧症患者のうち、過去に認知障害と診断されていない患者312例を対象に、認知機能障害の発生率とその決定要因について検討した。評価項目は患者背景、ミニメンタルステート検査、手段的日常生活動作(IADL)などとした。認知機能障害の高血圧患者109例(男性54例、平均79.0±6.5歳)、非認知機能障害の高血圧患者203例(男性95例、平均75.0±5.4歳)を対象とした。その結果、認知機能障害の高血圧患者は、非認知機能障害の高血圧患者と比較して、高齢で、教育水準が低く、IADLスコアが低かった。重回帰分析の結果、年齢およびIADLが高血圧患者の認知障害と関連していることが示された。両群間で診察室血圧および家庭血圧、降圧剤処方数、各降圧剤の使用割合は同程度であった。また、本試験に参加した認知機能障害の高血圧患者とORANGEレジストリに登録されたMCIを有する高血圧患者を比較した。その結果、本試験に参加した認知機能障害の高血圧患者はORANGEレジストリ患者と比較して降圧剤処方数が多く、重度の高血圧であることが示された。ORANGEレジストリ患者では本試験の患者と比較してIADL障害を有していることが示された。以上から、高血圧高齢患者は、たとえ機能的に自立していたとしても、隠れた認知機能低下リスクが高いことが示唆された。
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Makizako H, Kuwahata S, Takenaka T, Maeda M, Fujiwara S, Miyagawa K, Ikeda Y, Ohishi M. . The relationship between day-to-day variability in home blood pressure measurement and multiple organ function . Hypertens Res.45 ( 3 ) 474 - 482 2022.3Reviewed
Shimokihara S., Maruta M., Akasaki Y., Ikeda Y., Han G., Kamasaki T., Tokuda K., Hidaka Y., Akasaki Y., Tabira T. . Association between Frequency of Going Out and Psychological Condition among Community-Dwelling Older Adults after the COVID-19 Pandemic in Japan . Healthcare Switzerland10 ( 3 ) 2022.3

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Background: The psychological condition and frequency of going out (FGO) of community-dwelling older adults after the spread of COVID-19 will provide insights for supporting the daily lives of community-dwelling older adults. Going out is defined as moving from one’s own home to a place or region beyond one’s own home and is considered to reflect the daily and social life of community-dwelling older adults. This study investigates the relationship between the FGO and current psychological condition after the second wave of COVID-19 in community-dwelling older adults in Japan. Methods: This study adopted a self-administered questionnaire by mail. A total of 493 members of CO-OP Kagoshima were included in the analysis and divided into two groups according to the change in FGO. Multiple logistic regression analysis was conducted after a bivariate analysis to investigate the relationship between the FGO and psychological condition. Results: Significant differences were noted between the groups with decreased FGO and those with increased/unchanged FGO in general and pandemic-related psychological condition. Multiple logistic regression analysis showed a significant relationship between FGO and psychological condition, such as mental fatigue, not smiling as much as before, and anxiousness to go outside. Conclusion: Community-dwelling older adults may have experienced a decrease in the frequency of going out and a detrimental effect on their psychological condition after the COVID-19 pandemic. This finding may inform strategies to identify priorities for psychological approaches altered by COVID-19 to prevent confinement and stress in older adults.

DOI： 10.3390/healthcare10030439

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Kubozono Takuro, Akasaki Yuichi, Kawasoe Shin, Ojima Satoko, Kawabata Takeko, Makizako Hyuma, Kuwahata So, Takenaka Toshihiro, Maeda Mayuka, Fujiwara Seisuke, Miyagawa Ken, Ikeda Yoshiyuki, Ohishi Mitsuru . 家庭血圧測定の日間変動と複数臓器の機能との関係(The relationship between day-to-day variability in home blood pressure measurement and multiple organ function) . Hypertension Research45 ( 3 ) 474 - 482 2022.3

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Language：English Publisher：Nature Publishing Group

鹿児島県の地域健診受診者315名(女性201名、平均70±9歳)を対象に、血圧変動と臓器機能の関連について検討した。1ヵ月間(連日、起床後1時間以内)の家庭血圧値の変動係数(CV)四分位群間で心機能(脳性ナトリウム利尿ペプチド前駆体N端フラグメント(NT-proBNP)と高感度トロポニンT)、肝機能(Fib4 index)、腎機能(推算糸球体濾過量;eGFR)を比較した。多変量ロジスティック回帰分析の結果、収縮期血圧CV高位群ほどeGFR低値(<60mL/min/1.73m2)、Fib4 index高値(>2.67)、NT-proBNP高値(>70pg/mL[中央値])のオッズ比が高かった。高感度トロポニンT高値(>0.007ng/mL[中央値])との関連は全群で認められなかった。拡張期血圧CV高位群はNT-proBNP高値のオッズ比が高く、最高四分位群はFib4 index高値のオッズ比も高かったが、eGFR低値および高感度トロポニンT高値との関連はみられなかった。以上から、家庭血圧の日間変動は心臓、肝臓、腎臓のバイオマーカーと独立して関連していることが示された。
Kubozono Takuro, Akasaki Yuichi, Kawasoe Shin, Ojima Satoko, Kawabata Takeko, Makizako Hyuma, Kuwahata So, Takenaka Toshihiro, Maeda Mayuka, Fujiwara Seisuke, Miyagawa Ken, Ikeda Yoshiyuki, Ohishi Mitsuru . 家庭血圧測定の日間変動と複数臓器の機能との関係(The relationship between day-to-day variability in home blood pressure measurement and multiple organ function) . Hypertension Research45 ( 3 ) 474 - 482 2022.3

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Language：English Publisher：Nature Publishing Group

鹿児島県の地域健診受診者315名(女性201名、平均70±9歳)を対象に、血圧変動と臓器機能の関連について検討した。1ヵ月間(連日、起床後1時間以内)の家庭血圧値の変動係数(CV)四分位群間で心機能(脳性ナトリウム利尿ペプチド前駆体N端フラグメント(NT-proBNP)と高感度トロポニンT)、肝機能(Fib4 index)、腎機能(推算糸球体濾過量;eGFR)を比較した。多変量ロジスティック回帰分析の結果、収縮期血圧CV高位群ほどeGFR低値(<60mL/min/1.73m2)、Fib4 index高値(>2.67)、NT-proBNP高値(>70pg/mL[中央値])のオッズ比が高かった。高感度トロポニンT高値(>0.007ng/mL[中央値])との関連は全群で認められなかった。拡張期血圧CV高位群はNT-proBNP高値のオッズ比が高く、最高四分位群はFib4 index高値のオッズ比も高かったが、eGFR低値および高感度トロポニンT高値との関連はみられなかった。以上から、家庭血圧の日間変動は心臓、肝臓、腎臓のバイオマーカーと独立して関連していることが示された。
Kubozono T., Akasaki Y., Kawasoe S., Ojima S., Kawabata T., Makizako H., Kuwahata S., Takenaka T., Maeda M., Fujiwara S., Miyagawa K., Ikeda Y., Ohishi M. . The relationship between day-to-day variability in home blood pressure measurement and multiple organ function . Hypertension Research45 ( 3 ) 474 - 482 2022.3

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Language：Japanese Publisher：Hypertension Research

Blood pressure variability (BPV) is associated with the prognosis of cardiovascular diseases. However, it is unclear how BPV is related to various organs. The aim of this study is to investigate the association between BPV and multiple organ functions. A total of three hundred fifteen participants (114 males; mean age: 70 ± 9 years) participated in a community health checkup held in Tarumizu City. Home blood pressure (BP) was measured using a HEM-9700T (OMRON Healthcare, Kyoto, Japan). Day-to-day BPV was evaluated by the coefficient of variation (CV) of home BP measured in the morning for one month. N-terminal pro B-type natriuretic peptide (NT-pro BNP) and high-sensitivity (hs-)troponin T were measured as cardiac biomarkers. Liver stiffness and renal function were evaluated using the Fibrous-4 (Fib4) index and estimated glomerular filtration rate (eGFR), respectively. NT-pro BNP and hs-troponin T were divided by the median value. Fib4 index greater than 2.67 and eGFR less than 60 mL/min/1.73 m2 were defined as high Fib4 index and low eGFR, respectively. In a multivariable logistic regression analysis, the CV of systolic BP was significantly associated with high NT-pro BNP, high Fib 4 index, and low eGFR, but not with high hs-troponin T. In contrast, the CV of diastolic BP was not associated with low eGFR, and the other three biomarkers had the same results as systolic BP. In conclusion, day-to-day BPV of systolic BP is independently associated with NT-pro BNP, eGFR, and Fib4 index, but not with hs-troponin T. In contrast, diastolic BPV was not found to be associated with eGFR.

DOI： 10.1038/s41440-021-00818-8

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Kubozono T., Akasaki Y., Kawasoe S., Ojima S., Kawabata T., Makizako H., Kuwahata S., Takenaka T., Maeda M., Fujiwara S., Miyagawa K., Ikeda Y., Ohishi M. . The relationship between day-to-day variability in home blood pressure measurement and multiple organ function . Hypertens Res.45 ( 3 ) 474 - 482 2022.3Reviewed
Kusunose K, Yoshida H, Tanaka A, Teragawa H, Akasaki Y, Fukumoto Y, Eguchi K, Kamiya H, Kario K, Yamada H, Sata M, Node K; PRIZE Study Investigators. . Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study . Hypertens Res 45 ( 1 ) 106 - 115 2022.1Reviewed
Kusunose Kenya, Yoshida Hisako, Tanaka Atsushi, Teragawa Hiroki, Akasaki Yuichi, Fukumoto Yoshihiro, Eguchi Kazuo, Kamiya Haruo, Kario Kazuomi, Yamada Hirotsugu, Sata Masataka, Node Koichi, The PRIZE Study Investigators . 無症候性高尿酸血症患者におけるフェブキソスタットの左室拡張機能に対する効果 PRIZE試験のサブスタディ(Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study) . Hypertension Research45 ( 1 ) 106 - 115 2022.1

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高尿酸血症に対するキサンチンオキシダーゼ阻害剤フェブキソスタット(Feb)の血管障害予防効果を詳細に検討する多施設共同無作為化比較試験(PRIZE試験)のサブスタディを実施した。PRIZE試験全体の被験者のうち、ベースライン時、12ヵ月後、24ヵ月後に、左室流入血流拡張早期波高のピーク値(E)と拡張早期僧帽弁輪運動速度のピーク値(e')との比の心エコーデータを完全に追跡した65例(年齢中央値71歳)を対象とした(Feb追加投与群31例、対照群34例)。主要評価項目は、ベースラインから24ヵ月後までのE/e'の2群間の変化の比較とした。対照群ではFeb群と比較してe'が僅かに減少した(治療p=0.068、時間p=0.337、治療×時間p=0.217)。その結果、24ヵ月後のE/e'(治療p=0.045、時間p=0.177、治療×時間p=0.137)は、対照群においてFeb群と比較して有意に増加した。試験期間中、N末端プロB型ナトリウム利尿ペプチドと高感度トロポニンIの血清レベルには、両群間で有意差はなかった。以上より、無症候性高尿酸血症患者に対するFebの24ヵ月間の追加投与は、拡張機能障害に予防的効果をもたらす可能性があった。
Kusunose Kenya, Yoshida Hisako, Tanaka Atsushi, Teragawa Hiroki, Akasaki Yuichi, Fukumoto Yoshihiro, Eguchi Kazuo, Kamiya Haruo, Kario Kazuomi, Yamada Hirotsugu, Sata Masataka, Node Koichi, The PRIZE Study Investigators . 無症候性高尿酸血症患者におけるフェブキソスタットの左室拡張機能に対する効果　PRIZE試験のサブスタディ(Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study) . Hypertension Research45 ( 1 ) 106 - 115 2022.1

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Language：English Publisher：Nature Publishing Group

高尿酸血症に対するキサンチンオキシダーゼ阻害剤フェブキソスタット(Feb)の血管障害予防効果を詳細に検討する多施設共同無作為化比較試験(PRIZE試験)のサブスタディを実施した。PRIZE試験全体の被験者のうち、ベースライン時、12ヵ月後、24ヵ月後に、左室流入血流拡張早期波高のピーク値(E)と拡張早期僧帽弁輪運動速度のピーク値(e')との比の心エコーデータを完全に追跡した65例(年齢中央値71歳)を対象とした(Feb追加投与群31例、対照群34例)。主要評価項目は、ベースラインから24ヵ月後までのE/e'の2群間の変化の比較とした。対照群ではFeb群と比較してe'が僅かに減少した(治療p=0.068、時間p=0.337、治療×時間p=0.217)。その結果、24ヵ月後のE/e'(治療p=0.045、時間p=0.177、治療×時間p=0.137)は、対照群においてFeb群と比較して有意に増加した。試験期間中、N末端プロB型ナトリウム利尿ペプチドと高感度トロポニンIの血清レベルには、両群間で有意差はなかった。以上より、無症候性高尿酸血症患者に対するFebの24ヵ月間の追加投与は、拡張機能障害に予防的効果をもたらす可能性があった。
Kusunose K., Yoshida H., Tanaka A., Teragawa H., Akasaki Y., Fukumoto Y., Eguchi K., Kamiya H., Kario K., Yamada H., Sata M., Node K., Node K., Murohara T., Inoue T., Ohishi M., Yokote K., Watada H., Shimomura I., Matsuhisa M., Fukumoto Y., Maemura K., Ohya Y., Ako J., Amano H., Aonuma K., Aoyama Y., Arai H., Asai K., Asaka M., Awaji Y., Ban N., Ban T., Bando Y.K., Daida H., Eguchi S., Enomoto M., Fujii Y., Fujikake A., Fujimoto M., Fujisaka T., Fujita S., Fukae S., Fukuda D., Fukui M., Goriki Y., Hamasaki S., Hara T., Hasegawa H., Hashimoto K., Hata M., Hata S., Hayashida R., Higashi A., Higuchi S., Honda A., Hoshide S., Hoshiga M., Hotchi J., Igata S., Ikehara Y., Inoue Y., Ishigami H., Ishihara M., Ishii H., Ishikawa T., Ishimatsu T., Ishiyama Y., Ito T., Ito A., Kadokami T., Kashihara S., Kawamura Y., Kitagawa K., Kobayashi Y., Kodera S., Koga S., Koide H., Koide Y., Koiwaya H., Kojima H., Komai E., Komatsu T., Kono S., Kono T., Kubota Y., Kuroda A., Kuroyanagi T., Kushiyama A., Maruhashi T., Matsunaga K., Matsuura T., Mayama T., Mine D., Miyamura M. . Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study . Hypertension Research45 ( 1 ) 106 - 115 2022.1

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Hyperuricemia is related to an increased risk of cardiovascular events from a meta-analysis and antihyperuricemia agents may influence to cardiac function. We evaluated the effect of febuxostat on echocardiographic parameters of diastolic function in patients with asymptomatic hyperuricemia as a prespecified endpoint in the subanalysis of the PRIZE study. Patients in the PRIZE study were assigned randomly to either add-on febuxostat treatment group or control group with only appropriate lifestyle modification. Of the 514 patients in the overall study, 65 patients (31 in the febuxostat group and 34 in the control group) who had complete follow-up echocardiographic data of the ratio of peak early diastolic transmitral flow velocity (E) to peak early diastolic mitral annular velocity (e′) at baseline and after 12 and 24 months were included. The primary endpoint was a comparison of the changes in the E/e′ between the two groups from baseline to 24 months. Interestingly, e′ was slightly decreased in the control group compared with in the febuxostat group (treatment p = 0.068, time, p = 0.337, treatment × Time, p = 0.217). As a result, there were significant increases in E/e′ (treatment p = 0.045, time, p = 0.177, treatment × time, p = 0.137) after 24 months in the control group compared with the febuxostat group. There was no significant difference in the serum levels of N-terminal-pro brain natriuretic peptide and high-sensitive troponin I between the two groups during the study period. In conclusions, additional febuxostat treatment in patients with asymptomatic hyperuricemia for 24 months might have a potential of preventable effects on the impaired diastolic dysfunction.

DOI： 10.1038/s41440-021-00752-9

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Kusunose K., Yoshida H., Tanaka A., Teragawa H., Akasaki Y., Fukumoto Y., Eguchi K., Kamiya H., Kario K., Yamada H., Sata M., Node K., PRIZE Study Investigators . Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study . Hypertens Res45 ( 1 ) 106 - 115 2022.1Reviewed
Maruta M, Shimokihara S, Makizako H, Ikeda Y, Han G, Akasaki Y, Hidaka Y, Kamasaki T, Kubozono T, Ohishi M, Tabira T. . Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community-dwelling Japanese older adults . Psychogeriatrics22 651 - 658 2022Reviewed
Yamamoto K, Akasaka H, Yasunobe Y, Shimizu A, Nomono K, Nagai K, Umegaki H, Akasaki Y, Kojima T, Kozaki K, Kuzuya M, Ohishi M, Akishita M, Takami Y, Rakugi H, Xherry Study Group. . Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment . Hypertens Res45 ( 4 ) 612 - 619 2022Reviewed
Miyata H, Maruta M, Makizako H, Han G, Ikeda Y, Nakamura A, Tokuda K, Shimokihara S, Akaida S, Hidaka Y, Akasaki Y, Kubozono T, Ohishi M, Tabira T. . Association between satisfaction with meaningful activities and social frailty in community-dwelling Japanese older adults . Arch Gerontol Geriatr. 100 104665 2022
Kanouchi H, Yamashita M, Kaimoto K, Kuwabara A, Kawakami Y, Takenaka S, Koriyama C, Kuwahata S, Takenaka T, Akasaki Y, Kubozono T, Miyata M, Ohishi M. . Association of blood pressure and dietary intake of Sunomono, Japanese vinegared side dishes, in community-dwelling Japanese: A cross-sectional study . Heliyon 8 e09505 2022Reviewed
Miyata H., Maruta M., Makizako H., Han G., Ikeda Y., Nakamura A., Tokuda K., Shimokihara S., Akaida S., Hidaka Y., Akasaki Y., Kubozono T., Ohishi M., Tabira T. . Association between satisfaction with meaningful activities and social frailty in community-dwelling Japanese older adults . Arch Gerontol Geriatr.100 104665 2022
Koichi Yamamoto, Hiroshi Akasaka, Yukiko Yasunobe, Atsuya Shimizu, Kenichiro Nomoto, Kumiko Nagai, Hiroyuki Umegaki, Yuichi Akasaki, Taro Kojima, Koichi Kozaki, Masafumi Kuzuya, Mitsuru Ohishi, Masahiro Akishita, Yoichi Takami, Hiromi Rakugi . Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment. . Hypertension research : official journal of the Japanese Society of Hypertension45 ( 4 ) 612 - 619 2022Reviewed International journal

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To treat older patients with hypertension, it is important to detect cognitive impairment at an early stage because of its potential influence on treatment efficacy and functional prognosis. In this study, we aimed to identify the incidence and determinants of cognitive impairment in hypertensive patients aged 65 years and above who visited our outpatient clinic and were not previously diagnosed with cognitive impairment. Among 312 patients with hypertension, we found that 35% (n = 109) and 7.7% (n = 24) had cognitive impairment and dementia, respectively, as defined by the Mini-Mental State Examination (≤27 or ≤23, respectively). Patients with cognitive impairment were older, had lower levels of education, and had lower instrumental activities of daily living (IADL) scores than those without cognitive impairment. Multiple regression analysis revealed that age and IADL were associated with cognitive impairment in patients with hypertension. Regarding the treatment of hypertension, the office and home blood pressure levels, number of antihypertensive medications prescribed, and proportion of the use of each antihypertensive drug was equivalent between patients with and without cognitive impairment. Finally, patients with unrecognized cognitive impairment showed distinct clinical characteristics, including high antihypertensive medication burden and preserved IADL, when compared to hypertensive patients in the different cohorts of definitive mild cognitive impairment of a similar age. These findings suggest that older hypertensive patients are at a high risk of masked cognitive decline, even if they are functionally independent.

DOI： 10.1038/s41440-022-00861-z

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Maruta M., Shimokihara S., Makizako H., Ikeda Y., Han G., Akasaki Y., Hidaka Y., Kamasaki T., Kubozono T., Ohishi M., Tabira T. . Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community-dwelling Japanese older adults . Psychogeriatrics22 651 - 658 2022Reviewed
Sasaki Y, Ikeda Y, Uchikado Y, Akasaki Y, Sadoshima J, Ohishi M . Estrogen Plays a Crucial Role in Rab9-Dependent Mitochondrial Autophagy, Delaying Arterial Senescence . J Am Heart Assoc.10 ( 7 ) e019310 2021.4

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Publisher：Journal of the American Heart Association

DOI： 10.1161/JAHA.120.019310

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Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Makizako H, Kuwahata S, Takenaka T, Maeda M, Ohno M, Kijimuta M, Fujiwara S, Miyagawa K, Ohishi M . The relationship between home blood pressure measurement and room temperature in a Japanese general population . Hypertens Res .44 ( 4 ) 454 - 463 2021.4

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Publisher：Hypertension Research

DOI： 10.1038/s41440-020-00564-3

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Ohishi M, Kubozono T, Higuchi K, Akasaki Y. . Hypertension, cardiovascular disease, and nocturia: a systematic review of the pathophysiological mechanisms . Hypertens Res. 2021

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Publisher：Hypertension Research

DOI： 10.1038/s41440-021-00634-0

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Uchikado Y., Ikeda Y., Sasaki Y., Iwabayashi M., Akasaki Y., Ohishi M. . Association of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 With Angiotensin II Type 1 Receptor Impacts Mitochondrial Quality Control, Offering Promise for the Treatment of Vascular Senescence . Frontiers in Cardiovascular Medicine8 788655 2021

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Language：Japanese Publisher：Frontiers in Cardiovascular Medicine

Lectin-like oxidized low-density lipoprotein (ox-LDL) causes vascular senescence and atherosclerosis. It has been reported that ox-LDL scavenger receptor-1 (LOX-1) is associated with the angiotensin II type 1 receptor (AT1R). While mitochondria play a crucial role in the development of vascular senescence and atherosclerosis, they also undergo quality control through mitochondrial dynamics and autophagy. The aim of this study was to investigate (1) whether LOX-1 associates with AT1R, (2) if this regulates mitochondrial quality control, and (3) whether AT1R inhibition using Candesartan might ameliorate ox-LDL-induced vascular senescence. We performed in vitro and in vivo experiments using vascular smooth muscle cells (VSMCs), and C57BL/6 and apolipoprotein E-deficient (ApoE KO) mice. Administration of oxidized low-density lipoprotein (ox-LDL) to VSMCs induced mitochondrial dysfunction and cellular senescence accompanied by excessive mitochondrial fission, due to the activation of fission factor Drp1, which was derived from the activation of the Raf/MEK/ERK pathway. Administration of either Drp1 inhibitor, mdivi-1, or AT1R blocker candesartan attenuated these alterations. Electron microscopy and immunohistochemistry of the co-localization of LAMP2 with TOMM20 signal showed that AT1R inhibition also increased mitochondrial autophagy, but this was not affected by Atg7 deficiency. Conversely, AT1R inhibition increased the co-localization of LAMP2 with Rab9 signal. Moreover, AT1R inhibition-induced mitochondrial autophagy was abolished by Rab9 deficiency, suggesting that AT1R signaling modulated mitochondrial autophagy derived from Rab9-dependent alternative autophagy. Inhibition of the Raf/MEK/ERK pathway also decreased the excessive mitochondrial fission, and Rab9-dependent mitochondrial autophagy, suggesting that AT1R signaling followed the Raf/MEK/ERK axis modulated both mitochondrial dynamics and autophagy. The degree of mitochondrial dysfunction, reactive oxygen species production, vascular senescence, atherosclerosis, and the number of fragmented mitochondria accompanied by Drp1 activation were all higher in ApoE KO mice than in C57BL/6 mice. These detrimental alterations were successfully restored, and mitochondrial autophagy was upregulated with the administration of candesartan to ApoE KO mice. The association of LOX-1 with AT1R was found to play a crucial role in regulating mitochondrial quality control, as cellular/vascular senescence is induced by ox-LDL, and AT1R inhibition improves the adverse effects of ox-LDL.

DOI： 10.3389/fcvm.2021.788655

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Yamada Y, Enokida H, Harada H, Saito S, Miyauchi T, Nagatomi, S, Minami M, Mitsuke A., Ishihara T, Nishimura H, Tatarano S, Goto N, Akasaki Y, Nakagawa M . Successful Kidney Transplantation Alone With Severe Left Ventricular Systolic Dysfunction of Ejection Fraction 14%: A Case Report . Transplant Proc.52 ( 6 ) 1919 - 1923 2020.7

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Language：English Publisher：Transplantation Proceedings

DOI： 10.1016/j.transproceed.2020.02.146

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Ikeda Y, Sasaki T, Kuwahata S, Imamura M, Tanoue K, Komaki S, Hashiguchi M, Kuroda A, Akasaki Y, Ohishi M. . Management instructions for elderly patients with hypertension. . Clin Exp Hypertens.42 ( 4 ) 295 - 301 2020.5

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Language：English Publishing type：Research paper (scientific journal)
Akasaki Y, Ohishi, M. . Cerebrovascular and cardiovascular diseases caused by drugs of abuse . Hypertens Res.43 ( 5 ) 363 - 371 2020.5

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Publisher：Hypertension Research

DOI： 10.1038/s41440-019-0367-7

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Sasaki Y, Ikeda Y, Miyauchi T, Uchikado Y, Akasaki Y, Ohishi M. . Estrogen-SIRT1 axis plays a pivotal role in protecting arteries against menopause-induced senescence and atherosclerosis. . J Atheroscler Thromb27 ( 1 ) 47 - 59 2020.1

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Ikeda Y, Sasaki T, Kuwahata S, Imamura M, Tanoue K, Komaki S, Hashiguchi M, Kuroda A, Akasaki Y, Hamada C, Ohishi M. . Questionnaire survey from the viewpoint of concordance in patient and physician satisfaction concerning hypertensive treatment in elderly patients - patients voice study. . Circ J82 ( 4 ) 1051 - 1061 2018.3

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Sasaki Y, Ikeda Y, Iwabayashi M, Akasaki Y, Ohishi M . The Impact of Autophagy on Cardiovascular Senescence and Diseases . International Heart Journal58 ( 5 ) 666 - 673 2017

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Publisher：一般社団法人インターナショナル・ハート・ジャーナル刊行会

The risk of cardiovascular disease increases with age, causing chronic disability, morbidity, and mortality in the elderly. Cardiovascular aging and disease are characterized by heart failure, cardiac ischemia-reperfusion injury, cardiomyopathy, hypertension, arterial stiffness, and atherosclerosis. As a cell ages, damaged organelles and abnormal proteins accumulate. A system for removing these cytoplasmic substrates is essential for maintaining homeostasis. Autophagy assists tissue homeostasis by forming a pathway by which these substances are degraded. Growing evidence suggests that autophagy plays a role in age-related and disease states of the cardiovascular system, and it may even be effective in preventing or treating cardiovascular disease. On the other hand, overexpression of autophagy in the heart and arteries can produce detrimental effects. We summarize the current understanding of the close relationship between autophagy and cardiovascular senescence.

DOI： 10.1536/ihj.17-246

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PubMed

CiNii Research
Yoshimuta H, Nakamura M, Kanda E, Fujita S, Takeuchi K, Fujimoto T, Nakabeppu Y, Akasaki Y, Sano A . The effects of olanzapine treatment on brain regional glucose metabolism in neuroleptic-naive first-episode schizophrenic patients. . Human psychopharmacology31 ( 6 ) 419 - 426 2016.11

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DOI： 10.1002/hup.2558

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Cheng KK, Akasaki Y, Lecommandeur E, Lindsay RT, Murfitt S, Walsh K, Griffin JL. . Metabolomic analysis of Akt1-mediated muscle hypertrophy in models of diet-induced obesity and age-related fat accumulation. . J Proteome Res. 14 ( 1 ) 342 - 352 2015.1Reviewed

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Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K. . Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism. . Aging Cell. 13 ( 1 ) 80 - 91 2014.2Reviewed

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Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C . Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β-Expressing Macrophages. . Journal of the American Heart Association1 ( 4 ) e003079 2012.8

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DOI： 10.1161/JAHA.112.003079

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Araki S, Izumiya Y, Hanatani S, Rokutanda T, Usuku H, Akasaki Y, Takeo T, Nakagata N, Walsh K, Ogawa H . Akt1-Mediated Skeletal Muscle Growth Attenuates Cardiac Dysfunction and Remodeling after Experimental Myocardial Infarction. . Circ Heart Fail5 116 - 125 2012.1Reviewed

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Miyauchi T, Miyata M, Ikeda Y, Akasaki Y, Hamada N, Shirasawa T, Furusho Y, Tei C. . Waon Therapy Upregulates Hsp90 and Leads to Angiogenesis Through the Akt-Endothelial Nitric Oxide Synthase Pathway in Mouse Hindlimb Ischemia. . Circ J.76 ( 7 ) 1712 - 1721 2012.1Reviewed

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Hamada N, Miyata M, Eto H, Ikeda Y, Shirasawa T, Akasaki Y, Miyauchi T, Furusho Y, Nagaki A, Aronow BJ, Tei C. . Loss of clusterin limits atherosclerosis in apolipoprotein E-deficient mice via reduced expression of Egr-1 and TNF-α. . J Atheroscler Thromb.18 ( 3 ) 209 - 216 2011.1Reviewed

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Zeng L, Akasaki Y, Sato K, Ouchi N, Izumiya YY, Walsh K. . Insulin-like 6 is induced by muscle injury and functions as a regenerative factor. . J Biol Chem.285 ( 46 ) 36060 - 36069 2010.1Reviewed

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Shinsato T, Miyata M, Kubozono T, Ikeda Y, Fujita S, Kuwahata S, Akasaki Y, Hamasaki S, Fujiwara H, Tei C. . Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease. . J Cardiol. 56 ( 3 ) 361 - 366 2010.1Reviewed

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Hamada N, Miyata M, Eto H, Shirasawa T, Akasaki Y, Nagaki A, Tei C. . Tacrolimus-eluting stent inhibits neointimal hyperplasia via calcineurin/NFAT signaling in porcine coronary artery model. . Atherosclerosis. 208 ( 1 ) 97 - 103 2010.1Reviewed

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Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R, Akasaki Y, Shimono A, Walsh K. . Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity. . Science. 329 ( 5990 ) 454 - 457 2010.1Reviewed

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Maeda T, Akasaki Y, Yamamoto K, Aoyagi T . Stimuli-responsive coacervate induced in binary functionalized poly(N-isopropylacrylamide) aqueous system and novel method for preparing semi-ipn microgel using the coacervate. . Langmuir : the ACS journal of surfaces and colloids25 ( 16 ) 9510 - 7 2009.8

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DOI： 10.1021/la9007735

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Shirasawa T, Miyata M, Eto H, Hamada N, Akasaki Y, Miyauchi T, Furusho Y, Orihara K, Hamasaki S, Aronow BJ, Smith JD, Tei C. . Deficiency of clusterin inhibits neointimal hyperplasia after vascular injury. . J Atheroscler Thromb. 16 ( 6 ) 772 - 781 2009.1Reviewed

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Eto H, Miyata M, Shirasawa T, Akasaki Y, Hamada N, Nagaki A, Orihara K, Biro S, Tei C. . The long-term effect of angiotensin II type 1a receptor deficiency on hypercholesterolemia-induced atherosclerosis. . Hypertens Res. 31 ( 8 ) 1631 - 1642 2008.1Reviewed

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Izumiya Y, Bina HA, Ouchi N, Akasaki Y, Kharitonenkov A, Walsh K. . FGF21 is and Akt-regulated Myokine. . FEBS Lett. 582 ( 27 ) 3805 - 3810 2008.1Reviewed

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Akasaki Y, Miyata M, Eto H, Shirasawa T, Hamada N, Ikeda Y, Biro S, Otsuji Y, Tei C. . Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. . Circ J 70 463 - 470 2006.1Reviewed

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Higuchi K, Abe S, Matsuoka T, Nakajima H, Toda H, Akasaki Y, Torii H, Kuwahata S, Atsuchi Y, Mawatari K, Toyama Y, Saigo M, Ogawa M, Kawasaki T, Ootani T, Yamaguchi K, Mishima M, Tei C . [Usefulness of rapid quantitative cardiac troponin T and myoglobin assays for the diagnosis of acute myocardial infarction]. . Journal of cardiology41 ( 2 ) 55 - 62 2003.2Reviewed

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Higuchi K, Abe S, Matsuoka T, Nakajima H, Toda H, Akazaki Y, Torii H, Kuwahata S, Atsuchi Y, Mawatari K, Toyama Y, Saigo M, Ogawa M, Kawasaki T, Ootani T, Yamaguchi K, Mishima M, Tei C. . Usefulness of rapid quantitative cardiac troponin T and myoglobin assays for the diagnosis of acute myocardial infarction. . J Cardiol.41 ( 2 ) 55 - 62 2003.1Reviewed

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Akasaki Y . [Postconcussional syndrome]. . Ryoikibetsu shokogun shirizu ( 40 ) 236 - 9 2003

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PubMed
Cheng SB, Kuchiiwa S, Nagatomo I, Akasaki Y, Uchida M, Tominaga M, Hashiguchi W, Kuchiiwa T, Nakagawa S . 2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment induces c-Fos expression in the forebrain of the Long-Evans rat. . Brain research931 ( 2 ) 176 - 80 2002.3

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DOI： 10.1016/s0006-8993(02)02257-6

PubMed
Kuchiiwa S, Cheng SB, Nagatomo I, Akasaki Y, Uchida M, Tominaga M, Hashiguchi W, Kuchiiwa T . In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin decreases serotonin-immunoreactive neurons in raphe nuclei of male mouse offspring. . Neuroscience letters317 ( 2 ) 73 - 6 2002.1

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DOI： 10.1016/s0304-3940(01)02434-x

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Fujiwara H, Arima N, Akasaki Y, Ohtsubo H, Ozaki A, Kukita T, Matsushita K, Arimura K, Suruga Y, Wakamatsu S, Matsumoto T, Hidaka S, Eizuru Y, Tei C . Interferon-alpha therapy following autologous peripheral blood stem cell transplantation for adult T cell leukemia/lymphoma. . Acta haematologica107 ( 4 ) 213 - 9 2002

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DOI： 10.1159/000058317

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Nagatomo I, Akasaki Y, Tominaga M, Hashiguchi W, Uchida M, Takigawa M . Abnormal behavior of residents in a long-term care facility and the associated stress of care staff members. . Archives of gerontology and geriatrics33 ( 3 ) 203 - 10 2001.11

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DOI： 10.1016/s0167-4943(01)00182-0

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Nagatomo I, Akasaki Y, Hashiguchi W, Tominaga M, Uchida M, Takigawa M . A solvent used for antiepileptic drugs increases serum and brain zonisamide concentrations in seizure-susceptible el mice. . Epilepsy & behavior : E&B2 ( 4 ) 357 - 62 2001.8

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Language：English

DOI： 10.1006/ebeh.2001.0224

PubMed
Hashiguchi W, Nagatomo I, Akasaki Y, Uchida M, Tominaga M, Takigawa M . Influences of caffeine to nitric oxide production and zonisamide concentration in the brain of seizure-susceptible EL mice. . Psychiatry and clinical neurosciences55 ( 4 ) 319 - 24 2001.8

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DOI： 10.1046/j.1440-1819.2001.00870.x

PubMed
Tominaga M, Nagatomo I, Uchida M, Hashiguchi W, Akasaki Y, Takigawa M . Alterations of nitric oxide and monoamines in the brain of the EL mouse treated with phenobarbital and zonisamide. . Psychiatry and clinical neurosciences55 ( 4 ) 311 - 8 2001.8

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DOI： 10.1046/j.1440-1819.2001.00869.x

PubMed
Nagatomo I, Hashiguchi W, Tominaga M, Akasaki Y, Uchida M, Takigawa M . Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. . Brain research888 ( 2 ) 306 - 310 2001.1

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DOI： 10.1016/s0006-8993(00)03101-2

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Nagatomo I, Akasaki Y, Uchida M, Tominaga M, Hashiguchi W, Kuchiiwa S, Nakagawa S, Takigawa M . Age-related alterations of nitric oxide production in the brains of seizure-susceptible EL mice. . Brain research bulletin53 ( 3 ) 301 - 6 2000.10

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DOI： 10.1016/s0361-9230(00)00347-6

PubMed
Nagatomo I, Akasaki Y, Uchida M, Tominaga M, Hashiguchi W, Takigawa M . Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice. . Brain research bulletin53 ( 2 ) 211 - 8 2000.9

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DOI： 10.1016/s0361-9230(00)00333-6

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Nagatomo I, Uchida M, Akasaki Y, Hashiguchi W, Tominaga M, Kuchiiwa S, Nakagawa S, Takigawa M . The effect of alcohol on convulsions and nitric oxide levels in seizure-susceptible el mice. . Epilepsy & behavior : E&B1 ( 3 ) 176 - 83 2000.6

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DOI： 10.1006/ebeh.2000.0072

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Uchida M, Nagatomo I, Akasaki Y, Tominaga M, Hashiguchi W, Kuchiiwa S, Nakagawa S, Takigawa M . Nitric oxide production is decreased in the brain of the seizure susceptible EL mouse. . Brain research bulletin50 ( 4 ) 223 - 7 1999.11

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DOI： 10.1016/s0361-9230(99)00194-x

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Nagatomo I, Akasaki Y, Uchida M, Tominaga M, Hashiguchi W, Takigawa M . Gender of demented patients and specific family relationship of caregiver to patients influence mental fatigue and burdens on relatives as caregivers. . International journal of geriatric psychiatry14 ( 8 ) 618 - 25 1999.8

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DOI： 10.1002/(sici)1099-1166(199908)14:8<618::aid-gps989>3.0.co;2-b

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Nagatomo I, Akasaki Y, Uchida M, Tominaga M, Kuchiiwa S, Nakagawa S, Takigawa M . Kainic and domoic acids differentially affect NADPH-diaphorase neurons in the mouse hippocampal formation. . Brain research bulletin48 ( 3 ) 277 - 82 1999.2

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DOI： 10.1016/s0361-9230(98)00171-3

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Books

1361専門家による私の治療 2019-20年度版【電子版】

赤﨑雄一，大石　充（ Role： Joint author）

日本医事新報社 2019

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1336専門家による私の治療 2017 − 2018年度版 (下川宏明ほか編)

赤﨑雄一, 大石　充.（ Role： Joint author , 本態性高血圧症.）

日本医事新報社 2017

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Responsible for pages：321-323 Language：Japanese Book type：Scholarly book
日常診療に活かす診療ガイドラインUP-TO-DATE 2016-2017 (小室一成編).

赤﨑雄一, 大石　充.（ Role： Joint author , 高血圧.）

メディカルレビュー社 2016

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Responsible for pages：117-122. Language：Japanese Book type：Scholarly book

MISC

Comment on "When should Lenvatinib be switched to an alternative medication in patients with HCC who do not exhibit reactive blood pressure elevation?"(タイトル和訳中)

Akasaki Yuichi, Shibata Keisuke, Ohishi Mitsuru

Hypertension Research 48 ( 8 ) 2283 - 2284 2025.8

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Language：English Publisher：Nature Publishing Group
Makurazaki: a city of zero-hypertension(タイトル和訳中)

Ohishi Mitsuru, Akasaki Yuichi

Hypertension Research 48 ( 8 ) 2285 - 2286 2025.8

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Language：English Publisher：Nature Publishing Group
Comment on "When should Lenvatinib be switched to an alternative medication in patients with HCC who do not exhibit reactive blood pressure elevation?"(タイトル和訳中)

Akasaki Yuichi, Shibata Keisuke, Ohishi Mitsuru

Hypertension Research 48 ( 8 ) 2283 - 2284 2025.8

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Makurazaki: a city of zero-hypertension(タイトル和訳中)

Ohishi Mitsuru, Akasaki Yuichi

Hypertension Research 48 ( 8 ) 2285 - 2286 2025.8

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Language：English Publisher：Nature Publishing Group
肥満と循環器疾患循環器専門医の観点から　2. 肥満と高血圧

赤﨑雄一, 大石　充

HeartView 29 ( 6 ) 552 - 555 2025.6
肥満と循環器疾患循環器専門医の観点から 2. 肥満と高血圧

赤﨑雄一, 大石充

HeartView 29 ( 6 ) 552 - 555 2025.6
Comment on "When should Lenvatinib be switched to an alternative medication in patients with HCC who do not exhibit reactive blood pressure elevation?"

Akasaki Y, Shibata K, Ohishi M

Hypertens Res. 48 ( 8 ) 2283 - 2284 2025.5

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DOI： 10.1038/s41440-025-02234-8
高血圧管理の強化　従業員の医療機関受診を促す上で企業内健康管理担当者が果たす役割(Enhancing hypertension management: the role of corporate medical health administrators in encouraging hospital visits for workers)

Akasaki Yuichi

Hypertension Research 48 ( 5 ) 1799 - 1801 2025.5

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Language：English Publisher：Nature Publishing Group
Correction to: Enhancing hypertension management: the role of corporate medical health administrators in encouraging hospital visits for workers (Hypertension Research, (2025), 48, 5, (1799-1801), 10.1038/s41440-024-02062-2)

Akasaki Y.

Hypertension Research 48 ( 5 ) 1825 2025.5

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Language：Japanese Publisher：Hypertension Research

Correction to: Hypertension Researchhttps://doi.org/10.1038/s41440-024-02062-2 In this article ref. 6 was missing and should have been ‘Kudaka S, Sakima A, Nakamura K. Healthcare administrators and hypertension at small-to-medium worksites in Okinawa, Japan. Hypertens Res. 2025;48:168-79.’. The original article has been corrected.

DOI： 10.1038/s41440-025-02121-2

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PubMed
高血圧管理の強化従業員の医療機関受診を促す上で企業内健康管理担当者が果たす役割(Enhancing hypertension management: the role of corporate medical health administrators in encouraging hospital visits for workers)

Akasaki Yuichi

Hypertension Research 48 ( 5 ) 1799 - 1801 2025.5

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Language：English Publisher：Nature Publishing Group
高血圧診療Update 新しい降圧治療の立ち位置 ARNI(angiotensin receptor neprilysin inhibitor)

赤﨑雄一, 大石　充

腎と透析 98 ( ４ ) 510 - 515 2025.4
高血圧診療Update 新しい降圧治療の立ち位置 ARNI(angiotensin receptor neprilysin inhibitor)

赤﨑雄一, 大石充

腎と透析 98 ( 4 ) 510 - 515 2025.4
JSH2024 smoke-free declaration "Stop All Tobacco Products"

Arakawa K, Akasaki Y, Fukami A, Sakata S, Sugimoto K, Ryuno H, Kabayama M, Ohishi M; JSH Smoke-Free Promotion Committee members; Node K

Hypertens Res. 48 ( 2 ) 449 - 450 2025.2

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Language：Japanese Publisher：Hypertension Research

DOI： 10.1038/s41440-024-02073-z

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Makurazaki: a city of zero-hypertension.

Ohishi M, Akasaki Y

Hypertens Res. 48 ( 8 ) 2285 - 2286 2025.1

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DOI： 10.1038/s41440-025-02232-w
Enhancing hypertension management: the role of corporate medical health administrators in encouraging hospital visits for workers.

Akasaki Y

Hypertens Res. 48 ( 5 ) 1799 - 1801 2024.12

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DOI： 10.1038/s41440-024-02062-2
ペマフィブラート徐放性製剤の1日1回投与は1日2回投与よりも服薬アドヒアランスとトリグリセリドのコントロール能を高める(Once-daily Extended-Release Pemafibrate Enhances Adherence and Triglyceride Control Over Twice-Daily Dosing)

Akasaki Yuichi

Journal of Atherosclerosis and Thrombosis 31 ( 11 ) 1512 - 1514 2024.11

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Language：English Publisher：(一社)日本動脈硬化学会
ペマフィブラート徐放性製剤の1日1回投与は1日2回投与よりも服薬アドヒアランスとトリグリセリドのコントロール能を高める(Once-daily Extended-Release Pemafibrate Enhances Adherence and Triglyceride Control Over Twice-Daily Dosing)

Akasaki Yuichi

Journal of Atherosclerosis and Thrombosis 31 ( 11 ) 1512 - 1514 2024.11

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Language：English Publisher：(一社)日本動脈硬化学会
Angiogenic factors for early prediction of preeclampsia

Akasaki Y.

Hypertension Research 47 ( 10 ) 2959 - 2960 2024.10

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Language：Japanese Publisher：Hypertension Research

(Figure presented.)

DOI： 10.1038/s41440-024-01846-w

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妊娠高血圧腎症の早期予測に有用な血管新生因子(Angiogenic factors for early prediction of preeclampsia)

Akasaki Yuichi

Hypertension Research 47 ( 10 ) 2959 - 2960 2024.10

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Language：English Publisher：Nature Publishing Group
妊娠高血圧腎症の早期予測に有用な血管新生因子(Angiogenic factors for early prediction of preeclampsia)

Akasaki Yuichi

Hypertension Research 47 ( 10 ) 2959 - 2960 2024.10

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How should we manage hypertension and dyslipidemia to maintain cognitive function in older adults?

Akasaki Y., Ohishi M.

Hypertension Research 46 ( 8 ) 1880 - 1882 2023.8

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Language：Japanese Publisher：Hypertension Research

DOI： 10.1038/s41440-023-01327-6

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早朝・夜間高血圧の徹底管理－パーフェクト24時間血圧コントロールを目指して：降圧療法.

赤﨑雄一, 大石　充.

カレントテラピー 40 ( 9 ) 850 - 854 2022.9
早朝・夜間高血圧の徹底管理－パーフェクト24時間血圧コントロールを目指して：降圧療法.

赤﨑雄一, 大石充

カレントテラピー 40 ( 9 ) 850 - 854 2022.9
循環器・腎臓内科医が知りたい循環器・腎臓・高血圧治療のupdate：新規高血圧治療薬としてのARNI

赤﨑雄一, 大石　充

循環器内科 91 ( 5 ) 634 - 640 2022.5

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循環器・腎臓内科医が知りたい循環器・腎臓・高血圧治療のupdate：新規高血圧治療薬としてのARNI

赤﨑雄一, 大石充

循環器内科 91 ( 5 ) 634 - 640 2022.5

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Publisher：(有)科学評論社
高血圧症、心血管疾患、夜間頻尿　病態生理学的機序に関するシステマティックレビュー(Hypertension, cardiovascular disease, and nocturia: a systematic review of the pathophysiological mechanisms)

Ohishi Mitsuru, Kubozono Takuro, Higuchi Koji, Akasaki Yuichi

Hypertension Research 44 ( 7 ) 733 - 739 2021.7

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Language：English Publisher：Nature Publishing Group
治療抵抗性高血圧への対処：治療抵抗性高血圧の臓器障害評価.

赤﨑雄一, 大石　充.

月刊カレントテラピー 39 ( 1 ) 25 - 29 2021
低HDLコレステロール値と角膜混濁を呈した症例：動脈硬化症例 Q&A.

赤﨑雄一, 宮田昌明.

日本動脈硬化学会News and Scope QA2104 2021
生活習慣病の予防と治療高血圧.

赤﨑雄一, 大石　充.

臨牀と研究 98 1166 - 1171 2021
低HDLコレステロール値と角膜混濁を呈した症例：動脈硬化症例 Q&A.

赤﨑雄一, 宮田昌明

日本動脈硬化学会News and Scope QA2104 2021
生活習慣病の予防と治療高血圧.

赤﨑雄一, 大石充

臨牀と研究 98 1166 - 1171 2021
治療抵抗性高血圧への対処：治療抵抗性高血圧の臓器障害評価.

赤﨑雄一, 大石充

月刊カレントテラピー 39 ( 1 ) 25 - 29 2021
高血圧制圧のための地域医療.

赤﨑雄一, 大石　充.

日本臨牀増刊号高血圧学上 78 ( 1 ) 63 - 68 2020.6

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薬物乱用によって生じた脳血管疾患と心血管疾患(Rationale and Practical Method for Lifestyle Modification: Cerebrovascular and cardiovascular diseases caused by drugs of abuse)

Akasaki Y, Ohishi M

Hypertens Res. 43 ( 5 ) 363 - 371 2020.5

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Publisher：Nature Publishing Group
高齢者の高血圧治療.

赤﨑雄一, 大石　充.

診断と治療 108 ( 4 ) 501 - 506 2020.4

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
薬剤誘発性高血圧.

赤﨑雄一, 大石　充.

別冊日本臨牀循環器症候群 (第3版) Ⅳ 8 86 - 90 2020.3

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
高齢者高血圧における低い管理率を克服する戦略と課題

赤﨑雄一，大石　充

Geriatric Medicine（老年医学） 57 841 - 844 2019

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
脳血管障害合併高血圧の治療

赤﨑雄一，大石　充

循環器内科 85 779 - 784 2019

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
高血圧緊急性の管理

赤﨑雄一，大石　充

血圧 26 219 - 222 2019

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
血圧変動と臓器合併症のUpDate

赤﨑雄一, 大石　充.

血圧 25 682 - 685 2018

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
高齢者高血圧患者の高血圧治療の実際

赤﨑雄一, 大石　充.

カレントテラピー 36 52 - 58 2018

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
臓器障害のメカニズム研究の進歩.

赤﨑雄一, 大石　充.

心臓 50 506 - 510 2018

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
The Impact of Autophagy on Cardiovascular Senescence and Diseases.

Sasaki Y, Ikeda Y, Iwabayashi M, Akasaki Y, Ohishi M.

International Heart Journal 58 ( 5 ) 666 - 673 2017.9

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Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
オートファジーが心血管の老化および心血管疾患に及ぼす影響(The Impact of Autophagy on Cardiovascular Senescence and Diseases)

Sasaki Y, Ikeda Y, Iwabayashi M, Akasaki Y, Ohishi M

International Heart Journal 58 ( 5 ) 666 - 673 2017.9

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Publisher：(一社)インターナショナルハートジャーナル刊行会
ACE阻害薬 ARBではなくACE阻害薬を使う根拠は？

赤﨑雄一, 大石　充.

血圧 24 466 - 470 2017

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
カルシウム拮抗薬.

赤﨑雄一, 大石　充.

臨牀と研究 94 29 - 32 2017

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
高齢者の高血圧. Reviewed

赤﨑雄一, 大石　充.

心臓 47 420 - 424 2015

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
[Dipper, non-dipper pattern].

Akasaki Y, Ohishi M

Nihon rinsho. Japanese journal of clinical medicine 72 ( 8 ) 1400 - 3 2014.8

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PubMed
JNC8の9つの推奨. Reviewed

赤﨑雄一, 大石充.

血圧 21 10 - 14 2014.1

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
高血圧コントロールへの効果的なアプローチ-AHA/ACC/CDCの科学的勧告. Reviewed

赤崎雄一, 大石充

血圧,先端医学社 21 ( 6 ) 4 - 5 2014.1

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
血圧サーカディアンリズム-Dipper, non-Dipper型 Reviewed

赤崎雄一, 大石充

日本臨床,日本臨牀社 72 ( 8 ) 1400 - 1403 2014.1

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
高齢者の高血圧-高齢者高血圧のエビデンス. Reviewed

赤崎雄一, 大石充

老年医学,ライフ・サイエンス 52 ( 6 ) 637 - 640 2014.1

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
家庭血圧-白衣高血圧（低リスクと高リスク）の治療. Reviewed

赤崎雄一, 大石充

カレントテラピー,ライフメディコム 32 ( 3 ) 52 - 56 2014.1

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Presentations

上坊翔太, 池田義之, 内門義博, 佐々木雄一, 赤﨑雄一, 大石　充血管老化および骨格筋委縮に対するエストロゲンのマイトファジーを介した多面的保護効果について.

第45回日本高血圧学会総会 2023.9

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Event date： 2023.9

Venue：大阪市
柴田啓佑, 迫田　隆, 赤﨑雄一, 池田義之, 大石　充レンバチニブ投与中の高血圧治療に難渋した子宮体癌の一例

第45回日本高血圧学会総会 2023.9

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Event date： 2023.9

Venue：大阪市
赤﨑雄一, 大石　充シンポジウム10. フレイル・ロコモ克服に向けた高血圧制圧.高血圧とフレイル・ロコモ.

第45回日本高血圧学会総会 2023.9

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Event date： 2023.9

Venue：大阪市
上坊翔太, 池田義之, 内門義博, 佐々木雄一, 赤﨑雄一, 大石充血管老化および骨格筋委縮に対するエストロゲンのマイトファジーを介した多面的保護効果について.

第45回日本高血圧学会総会 2023.9

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Event date： 2023.9

Venue：大阪市
赤﨑雄一, 大石充シンポジウム10. フレイル・ロコモ克服に向けた高血圧制圧.高血圧とフレイル・ロコモ.

第45回日本高血圧学会総会 2023.9

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Event date： 2023.9

Venue：大阪市
柴田啓佑, 迫田隆, 赤﨑雄一, 池田義之, 大石充レンバチニブ投与中の高血圧治療に難渋した子宮体癌の一例

第45回日本高血圧学会総会 2023.9

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Event date： 2023.9

Venue：大阪市
柴田啓佑, 徳重明央, 内山奈美, 赤﨑雄一, 窪薗琢郎, 権藤なおみ, 相良安昭, 池田義之, 大石　充乳腺動脈石灰化と冠動脈石灰化の関連の検討

第71回日本心臓病学会学術集会 2023.9

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Event date： 2023.9

Venue：横浜市
上坊翔太, 池田義之, 佐々木雄一, 内門義博, 赤﨑雄一, 大石　充マイトファジーは閉経に伴う血管老化やサルコペニア進展に対する包括的治療ターゲットとなる.

第71回日本心臓病学会学術集会 2023.9

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Event date： 2023.9

Venue：横浜市
迫田　隆, 赤﨑雄一, 内門義博, 佐々木雄一, 川添　晋, 徳重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石充慢性腎臓病発症に関わるトリグリセリド-グルコース(TyG)インデックスの性差・年代差

第71回日本心臓病学会学術集会 2023.9

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Event date： 2023.9

Venue：横浜市
上坊翔太, 池田義之, 佐々木雄一, 内門義博, 赤﨑雄一, 大石充マイトファジーは閉経に伴う血管老化やサルコペニア進展に対する包括的治療ターゲットとなる.

第71回日本心臓病学会学術集会 2023.9

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Event date： 2023.9

Venue：横浜市
柴田啓佑, 徳重明央, 内山奈美, 赤﨑雄一, 窪薗琢郎, 権藤なおみ, 相良安昭, 池田義之, 大石充乳腺動脈石灰化と冠動脈石灰化の関連の検討

第71回日本心臓病学会学術集会 2023.9

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Event date： 2023.9

Venue：横浜市
迫田隆, 赤﨑雄一, 内門義博, 佐々木雄一, 川添晋, 徳重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石充慢性腎臓病発症に関わるトリグリセリド-グルコース(TyG)インデックスの性差・年代差

第71回日本心臓病学会学術集会 2023.9

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Event date： 2023.9

Venue：横浜市
迫田　隆, 赤﨑雄一, 佐々木雄一, 川添　晋, 德重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石　充. 上腕-足首脈波伝播速度とトリグリセリド-グルコースインデックスとの関連.

第65回日本老年医学会学術集会 2023.6

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Event date： 2023.6

Venue：横浜市
上坊翔太, 池田義之, 内門義博, 佐々木雄一, 赤﨑雄一, 大石　充エストロゲンのマイトファジーを介した骨格筋芽細胞分化効果

第65回日本老年医学会学術集会 2023.6

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Event date： 2023.6

Venue：横浜市
内門義博, 池田義之, 上坊翔太, 佐々木雄一, 赤﨑雄一, 大石　充糖尿病に伴うサルコペニアの病態に終末糖化産物によるAutophagic Flux抑制を介した骨格筋分化能低下が関与する

第65回日本老年医学会学術集会 2023.6

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Event date： 2023.6

Venue：横浜市
上坊翔太, 池田義之, 内門義博, 佐々木雄一, 赤﨑雄一, 大石充エストロゲンのマイトファジーを介した骨格筋芽細胞分化効果

第65回日本老年医学会学術集会 2023.6

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Event date： 2023.6

Venue：横浜市
迫田隆, 赤﨑雄一, 佐々木雄一, 川添晋, 德重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石充上腕-足首脈波伝播速度とトリグリセリド-グルコースインデックスとの関連.

第65回日本老年医学会学術集会 2023.6

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Event date： 2023.6

Venue：横浜市
内門義博, 池田義之, 上坊翔太, 佐々木雄一, 赤﨑雄一, 大石充糖尿病に伴うサルコペニアの病態に終末糖化産物によるAutophagic Flux抑制を介した骨格筋分化能低下が関与する

第65回日本老年医学会学術集会 2023.6

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Event date： 2023.6

Venue：横浜市
迫田　隆, 赤﨑雄一, 内門義博, 佐々木雄一, 川添　晋, 德重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石　充トリグリセリド-グルコース（TyG）インデックスと, 将来の慢性腎臓病発症との関連

第59回日本循環器病予防学会学術集会 2023.6

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Event date： 2023.6

Venue：鹿児島市
内門義博, 池田義之, 上坊翔太, 佐々木雄一, 赤﨑雄一, 大石　充 AT1受容体阻害は脂質異常に伴う動脈硬化性心血管疾患予防上の残余リスク軽減の要である：基礎研究による検討

第59回日本循環器病予防学会学術集会 2023.6

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Event date： 2023.6

Venue：鹿児島市
上坊翔太, 池田義之, 内門義博, 佐々木雄一, 赤﨑雄一, 大石　充 Rab9 依存性オルタナティブオートファジーは閉経後女性サルコペニア発症を予防するための治療ターゲットとなる

第59回日本循環器病予防学会学術集会 2023.6

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Event date： 2023.6

Venue：鹿児島市
内門義博, 池田義之, 上坊翔太, 佐々木雄一, 赤﨑雄一, 大石充 AT1受容体阻害は脂質異常に伴う動脈硬化性心血管疾患予防上の残余リスク軽減の要である：基礎研究による検討

第59回日本循環器病予防学会学術集会 2023.6

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Event date： 2023.6

Venue：鹿児島市
迫田隆, 赤﨑雄一, 内門義博, 佐々木雄一, 川添晋, 德重明央, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石充トリグリセリド-グルコース（TyG）インデックスと, 将来の慢性腎臓病発症との関連

第59回日本循環器病予防学会学術集会 2023.6

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Event date： 2023.6

Venue：鹿児島市
上坊翔太, 池田義之, 内門義博, 佐々木雄一, 赤﨑雄一, 大石充 Rab9 依存性オルタナティブオートファジーは閉経後女性サルコペニア発症を予防するための治療ターゲットとなる

第59回日本循環器病予防学会学術集会 2023.6

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Event date： 2023.6

Venue：鹿児島市
Sakoda T, Akasaki Y, Sasaki Y, Kawasoe S, Kubozono T, Ikeda Y, Ohishi M Characteristics of isolated diastolic hypertension which progresses to systolic diastolic hypertension

第87回日本循環器学会学術集会 2023.3

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Event date： 2023.3

Venue：福岡市
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Ikeda Y, Tezuka A, Kuwahata S, Takenaka T, Ohishi M Effect of defecation status on blood pressure variability

第87回日本循環器学会学術集会 2023.3

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Event date： 2023.3

Venue：福岡市
Sakoda T., Akasaki Y., Sasaki Y., Kawasoe S., Kubozono T., Ikeda Y., Ohishi M. Characteristics of isolated diastolic hypertension which progresses to systolic diastolic hypertension

第87回日本循環器学会学術集会 2023.3

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Event date： 2023.3

Venue：福岡市
Kubozono T., Akasaki Y., Kawasoe S., Ojima S., Kawabata T., Ikeda Y., Tezuka A., Kuwahata S., Takenaka T., Ohishi M. Effect of defecation status on blood pressure variability

第87回日本循環器学会学術集会 2023.3

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Event date： 2023.3

Venue：福岡市
迫田隆, 赤﨑雄一, 川添晋, 佐々木雄一, 内門義博, 池田義之, 大石充高血圧の基準値と高血圧発症リスク因子の関係.

第34回血圧管理研究会

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Event date： 2022.12

Venue：京都府向日市
窪薗琢郎, 赤﨑雄一, 川添晋, 小島聡子, 川畑孟子, 桑波田聡, 竹中俊宏, 池田義之, 大石充排便状態と経時的な血圧変動性との関連.

第34回血圧管理研究会

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Event date： 2022.12

Venue：京都府向日市
窪薗琢郎, 赤﨑雄一, 川添　晋, 小島聡子, 川畑孟子, 桑波田聡, 竹中俊宏, 池田義之, 大石　充. 排便状態と経時的な血圧変動性との関連.

第34回血圧管理研究会

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Event date： 2022.12

Venue：京都府向日市
迫田　隆, 赤﨑雄一, 川添　晋, 佐々木雄一, 内門義博, 池田義之, 大石　充. 高血圧の基準値と高血圧発症リスク因子の関係.

第34回血圧管理研究会

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Event date： 2022.12

Venue：京都府向日市
佐々木雄一, 池田義之, 内門義博, 赤﨑雄一, 大石充九州若手研究者エンカレッジメントセッション（ISHR U45ジョイントシンポジウム）. 血管老化研究.

第133回日本循環器学会九州地方会

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Event date： 2022.12

Venue：久留米市
佐々木雄一, 池田義之, 内門義博, 赤﨑雄一, 大石　充. 九州若手研究者エンカレッジメントセッション（ISHR U45ジョイントシンポジウム）. 血管老化研究.

第133回日本循環器学会九州地方会

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Event date： 2022.12

Venue：久留米市
窪薗琢郎, 川添晋, 小島聡子, 川畑孟子, 赤﨑雄一, 桑波田聡, 竹中俊宏, 池田義之, 大石充測定時の室温と中期的な家庭血圧の変化の関連.

第8回日本心臓リハビリテーション学会九州地方会

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Event date： 2022.11

Venue：宮崎市
窪薗琢郎, 川添　晋, 小島聡子, 川畑孟子, 赤﨑雄一, 桑波田聡, 竹中俊宏, 池田義之, 大石　充. 測定時の室温と中期的な家庭血圧の変化の関連.

第8回日本心臓リハビリテーション学会九州地方会

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Event date： 2022.11

Venue：宮崎市
Uchikado Y, Ikeda Y, Uebo S, Sasaki Y, Akasaki Y, Ohishi M. Angiotensin II type1 receptor inhibition improves vascular senescence through improvement of mitochondrial quality control via CRAF/MEK/ERK pathway International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
Uebo S, Ikeda Y, Uchikado Y, Akasaki Y, Ohishi M. Angiotensin II type I receptor signal regulates mitochondrial dynamics, causing muscular mitochondrial dysfunction and sarcopenia under metabolic stress. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
Sakoda T, Akasaki Y, Kawasoe S, Kubozono T, Sasaki Y, Ikeda Y, Ohishi M, Miyahara H, Tokushige K. Differences in risk factors for developing hypertension when hypertension reference values are changed. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
Sakoda T, Akasaki Y, Kawasoe S, Kubozono T, Sasaki Y, Ikeda Y, Ohishi M, Miyahara H, Tokushige K. Factors for new-onset isolated diastolic hypertension and progression to systolic hypertension in Japan. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
Shibata K, Tokushige A, Nitta M, Akasaki Y, Higuchi K, Ikeda Y, Ohishi M. Hypertension due to Lenvatinib induction. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Anwar Ahmed Salim, Ikeda Y, Ohishi M. Association between defecation status and blood pressure variability. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
Uebo S., Ikeda Y., Uchikado Y., Akasaki Y., Ohishi M. Angiotensin II type I receptor signal regulates mitochondrial dynamics, causing muscular mitochondrial dysfunction and sarcopenia under metabolic stress. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
Shibata K., Tokushige A., Nitta M., Akasaki Y., Higuchi K., Ikeda Y., Ohishi M. Hypertension due to Lenvatinib induction. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
Sakoda T., Akasaki Y., Kawasoe S., Kubozono T., Sasaki Y., Ikeda Y., Ohishi M., Miyahara H., Tokushige K. Factors for new-onset isolated diastolic hypertension and progression to systolic hypertension in Japan. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

　More details

Event date： 2022.10

Venue：Kyoto, Japan
Sakoda T., Akasaki Y., Kawasoe S., Kubozono T., Sasaki Y., Ikeda Y., Ohishi M., Miyahara H., Tokushige K. Differences in risk factors for developing hypertension when hypertension reference values are changed. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

　More details

Event date： 2022.10

Venue：Kyoto, Japan
Kubozono T., Akasaki Y., Kawasoe S., Ojima S., Kawabata T., Anwar Ahmed Salim, Ikeda Y., Ohishi M. Association between defecation status and blood pressure variability. International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
Uchikado Y., Ikeda Y., Uebo S., Sasaki Y., Akasaki Y., Ohishi M. Angiotensin II type1 receptor inhibition improves vascular senescence through improvement of mitochondrial quality control via CRAF/MEK/ERK pathway International conference

The 29th Scientific Meeting of the International Society of Hypertension (ISH2022)

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Event date： 2022.10

Venue：Kyoto, Japan
迫田　隆, 赤﨑雄一, 德重明央, 内門義博, 上坊翔太, 佐々木雄一, 川添　晋, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石　充. トリグリセリド-グルコースインデックスは動脈硬化発症の予測因子となりうる.

第70回日本心臓病学会学術集会

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Event date： 2022.9

Venue：京都市
迫田隆, 赤﨑雄一, 德重明央, 内門義博, 上坊翔太, 佐々木雄一, 川添晋, 窪薗琢郎, 池田義之, 宮原広典, 徳重浩一, 大石充トリグリセリド-グルコースインデックスは動脈硬化発症の予測因子となりうる.

第70回日本心臓病学会学術集会

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Event date： 2022.9

Venue：京都市
柴田啓佑, 德重明央, 新田美奈, 赤﨑雄一, 樋口公嗣, 池田義之, 大石　充. レンバチニブ導入時の高血圧症についての検討.

第5回日本腫瘍循環器学会学術集会

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Event date： 2022.9
柴田啓佑, 德重明央, 新田美奈, 赤﨑雄一, 樋口公嗣, 池田義之, 大石充レンバチニブ導入時の高血圧症についての検討.

第5回日本腫瘍循環器学会学術集会

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Event date： 2022.9
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. 第30回若手研究者奨励賞受賞講演. LOX-1-AT1R受容体連関/ミトコンドリアダイナミクス/マイトファジーは動脈硬化治療の重要な治療ターゲットである.

第54回日本動脈硬化学会総会・学術集会

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Event date： 2022.7

Venue：久留米市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石充第30回若手研究者奨励賞受賞講演. LOX-1-AT1R受容体連関/ミトコンドリアダイナミクス/マイトファジーは動脈硬化治療の重要な治療ターゲットである.

第54回日本動脈硬化学会総会・学術集会

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Event date： 2022.7

Venue：久留米市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. ARBはミトコンドリアダイナミクスのバランスを取ることで脂質異常症による血管老化を抑制する

第64回日本老年医学会学術集会

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Event date： 2022.6

Venue：大阪市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石充 ARBはミトコンドリアダイナミクスのバランスを取ることで脂質異常症による血管老化を抑制する

第64回日本老年医学会学術集会

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Event date： 2022.6

Venue：大阪市
Sakoda T, Akasaki Y, Sasaki Y, Kawasoe S, Kubozono T, Ikeda Y, Ohishi M. Characteristics of isolated diastolic hypertension which progresses to systolic diastolic hypertension

第86回日本循環器学会学術集会

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Event date： 2022.3
Sakoda T, Akasaki Y, Kawasoe S, Sasaki Y, Ikeda Y, Ohishi M. Predictors of new-onset isolated diastolic hypertension and progression to systolic hypertension in Japan

第86回日本循環器学会学術集会

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Event date： 2022.3
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Yamaguchi S, Kuwahata S, Takenaka T, Ohishi M. The effect of room temperature during measurement on short-term change of home blood pressure level

第86回日本循環器学会学術集会

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Event date： 2022.3
Sakoda T., Akasaki Y., Sasaki Y., Kawasoe S., Kubozono T., Ikeda Y., Ohishi M. Characteristics of isolated diastolic hypertension which progresses to systolic diastolic hypertension

第86回日本循環器学会学術集会

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Event date： 2022.3
Kubozono T., Akasaki Y., Kawasoe S., Ojima S., Kawabata T., Yamaguchi S., Kuwahata S., Takenaka T., Ohishi M. The effect of room temperature during measurement on short-term change of home blood pressure level

第86回日本循環器学会学術集会

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Event date： 2022.3
Sakoda T., Akasaki Y., Kawasoe S., Sasaki Y., Ikeda Y., Ohishi M. Predictors of new-onset isolated diastolic hypertension and progression to systolic hypertension in Japan

第86回日本循環器学会学術集会

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Event date： 2022.3
迫田隆, 赤﨑雄一, 川添晋, 佐々木雄一, 内門義博, 池田義之, 大石充 ACC/AHA2017の高血圧基準値変更による高血圧発症リスク因子の変化.

第32回日本老年医学会九州地方会

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Event date： 2022.2
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石充脂質異常はAT1Rを介してミトコンドリア質管理を低下させ血管老化を来す.

第32回日本老年医学会九州地方会

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Event date： 2022.2
迫田　隆, 赤﨑雄一, 川添　晋, 佐々木雄一, 内門義博, 池田義之, 大石　充. ACC/AHA2017の高血圧基準値変更による高血圧発症リスク因子の変化.

第32回日本老年医学会九州地方会

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Event date： 2022.2
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. 脂質異常はAT1Rを介してミトコンドリア質管理を低下させ血管老化を来す.

第32回日本老年医学会九州地方会

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Event date： 2022.2
下園夏帆, 迫田　隆, 佐々木雄一, 吉元一成, 二宮雄一, 赤﨑雄一, 窪薗琢郎, 池田義之, 大石　充. SARS-CoV-2ワクチン接種後に遷延する心嚢液貯留を呈した一例.

第131回日本循環器学会九州地方会

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Event date： 2021.12
下園夏帆, 迫田隆, 佐々木雄一, 吉元一成, 二宮雄一, 赤﨑雄一, 窪薗琢郎, 池田義之, 大石充 SARS-CoV-2ワクチン接種後に遷延する心嚢液貯留を呈した一例.

第131回日本循環器学会九州地方会

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Event date： 2021.12
窪薗琢郎, 赤﨑雄一, 川添　晋, 小島聡子, 川畑孟子, 桑波田聡, 竹中俊宏, 池田義之, 大石　充. 家庭血圧の短期的変化と測定時の気温との関連.

第33回血圧管理研究会

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Event date： 2021.11
窪薗琢郎, 赤﨑雄一, 川添晋, 小島聡子, 川畑孟子, 桑波田聡, 竹中俊宏, 池田義之, 大石充家庭血圧の短期的変化と測定時の気温との関連.

第33回血圧管理研究会

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Event date： 2021.11
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Ikeda Y, Ohishi M. The relationship between day-to-day variability in home blood pressure and multiple organ function. International conference

American Heart Association’s annual Scientific Sessions 2021

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Event date： 2021.11
Kubozono T., Akasaki Y., Kawasoe S., Ojima S., Kawabata T., Ikeda Y., Ohishi M. The relationship between day-to-day variability in home blood pressure and multiple organ function. International conference

American Heart Association’s annual Scientific Sessions 2021

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Event date： 2021.11
赤﨑雄一. 教育講演（Meet the Expert）（循環器疾患とフレイル）心血管疾患とサルコペニア・フレイル.

第8回日本サルコペニア・フレイル学会大会

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Event date： 2021.11

Venue：京都市
赤﨑雄一教育講演（Meet the Expert）（循環器疾患とフレイル）心血管疾患とサルコペニア・フレイル.

第8回日本サルコペニア・フレイル学会大会

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Event date： 2021.11

Venue：京都市
Uchikado Y, Ikeda Y, Sasaki Y, Akasaki Y, Ohishi M. Receptor association of lectin-like oxidized low-density lipoprotein scavenger receptor-1 with angiotensin II type 1 receptor followed by mitochondrial quality control is an innovative therapeutic concept for targeting vascular senescence induced by oxidized low-density lipoprotein.

The 19th International Symposium on Atherosclerosis

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Event date： 2021.10

Venue：Kyoto, Japan
Uchikado Y., Ikeda Y., Sasaki Y., Akasaki Y., Ohishi M. Receptor association of lectin-like oxidized low-density lipoprotein scavenger receptor-1 with angiotensin II type 1 receptor followed by mitochondrial quality control is an innovative therapeutic concept for targeting vascular senescence induced by oxidized low-density lipoprotein.

The 19th International Symposium on Atherosclerosis

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Event date： 2021.10

Venue：Kyoto, Japan
迫田　隆, 赤﨑雄一, 川添　晋, 佐々木雄一, 内門義博, 池田義之, 大石　充. 高血圧発症のリスク因子：JSH2019とACC/AHA2017基準値における比較.

第53回日本動脈硬化学会総会・学術集会

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Event date： 2021.10

Venue：京都市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. AT1R阻害はLOX-1/AT1R 受容体連関によるRas/Raf/MEK/ERK系を介したミトコンドリア質管理を改善することで抗血管老化を来す.

第53回日本動脈硬化学会総会・学術集会

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Event date： 2021.10

Venue：京都市
迫田隆, 赤﨑雄一, 川添晋, 佐々木雄一, 内門義博, 池田義之, 大石充高血圧発症のリスク因子：JSH2019とACC/AHA2017基準値における比較.

第53回日本動脈硬化学会総会・学術集会

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Event date： 2021.10

Venue：京都市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石充 AT1R阻害はLOX-1/AT1R 受容体連関によるRas/Raf/MEK/ERK系を介したミトコンドリア質管理を改善することで抗血管老化を来す.

第53回日本動脈硬化学会総会・学術集会

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Event date： 2021.10

Venue：京都市
迫田　隆, 赤﨑雄一, 川添　晋, 佐々木雄一, 内門義博, 池田義之, 大石　充. 高血圧発症のリスク因子：JSH2019とACC/AHA2017基準値における比較

第43回日本高血圧学会総会

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Event date： 2021.10
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. AT1R阻害はLOX-1/AT1R 受容体連関によるRaf/MEK/ERK系を介したミトコンドリア質管理によりox-LDL誘発の血管老化を改善する.

第43回日本高血圧学会総会

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Event date： 2021.10
迫田隆, 赤﨑雄一, 川添晋, 佐々木雄一, 内門義博, 池田義之, 大石充高血圧発症のリスク因子：JSH2019とACC/AHA2017基準値における比較

第43回日本高血圧学会総会

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Event date： 2021.10
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石充 AT1R阻害はLOX-1/AT1R 受容体連関によるRaf/MEK/ERK系を介したミトコンドリア質管理によりox-LDL誘発の血管老化を改善する.

第43回日本高血圧学会総会

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Event date： 2021.10
佐々木雄一, 池田義之, 内門義博, 赤﨑雄一, 大石　充. エストロゲンのSirt1/LKB1/AMPK/Ulk1/Rab9経路を介したマイトファジー誘導による血管老化・動脈硬化抑制作用.

第69回日本心臓病学会学術集会

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Event date： 2021.9

Venue：鳥取県米子市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. 脂質異常に対するAT1R阻害の新たな可能性：ミトコンドリア質管理を介した抗血管老化および抗動脈硬化効果.

第69回日本心臓病学会学術集会

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Event date： 2021.9

Venue：鳥取県米子市
佐々木雄一, 池田義之, 内門義博, 赤﨑雄一, 大石充エストロゲンのSirt1/LKB1/AMPK/Ulk1/Rab9経路を介したマイトファジー誘導による血管老化・動脈硬化抑制作用.

第69回日本心臓病学会学術集会

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Event date： 2021.9

Venue：鳥取県米子市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石充脂質異常に対するAT1R阻害の新たな可能性：ミトコンドリア質管理を介した抗血管老化および抗動脈硬化効果.

第69回日本心臓病学会学術集会

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Event date： 2021.9

Venue：鳥取県米子市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. 過酸化脂質による血管老化の治療はLOXとAT1受容体との受容体連関によるミトコンドリア質管理低下が重要なターゲットになる.

第21回日本抗加齢医学会総会

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Event date： 2021.6

Venue：京都市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石充過酸化脂質による血管老化の治療はLOXとAT1受容体との受容体連関によるミトコンドリア質管理低下が重要なターゲットになる.

第21回日本抗加齢医学会総会

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Event date： 2021.6

Venue：京都市
窪薗琢郎, 赤﨑雄一, 川添　晋, 小島聡子, 川畑孟子，山口　聡, 大野真由, 前田真由香, 竹中俊宏, 大石　充一般住民における血圧管理の現状と課題.

第27回日本心臓リハビリテーション学会学術集会

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Event date： 2021.6

Venue：千葉市
窪薗琢郎, 赤﨑雄一, 川添晋, 小島聡子, 川畑孟子, 山口聡, 大野真由, 前田真由香, 竹中俊宏, 大石充一般住民における血圧管理の現状と課題.

第27回日本心臓リハビリテーション学会学術集会

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Event date： 2021.6

Venue：千葉市
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. AT1R阻害はLOX-1/AT1R 受容体連関によるミトコンドリア質管理低下を改善させる.

第63回日本老年医学会学術集会

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Event date： 2021.6
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石充 AT1R阻害はLOX-1/AT1R 受容体連関によるミトコンドリア質管理低下を改善させる.

第63回日本老年医学会学術集会

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Event date： 2021.6
Akasaki Y, Kubozono T, Higuchi K, Ohishi M. Relationships between anti hypertensive drugs and nocturia: a systematic review. International conference

Joint Meeting of the European Society of Hypertension and International Society of Hypertension

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Event date： 2021.4

Language：English

Venue：Glasgow, UK
Sakoda T, Akasaki Y, Kubozono T, Ikeda Y, Ohishi M. Factor analysis of untreated hypertension from Tarumizu study. International conference

Joint Meeting of the European Society of Hypertension and International Society of Hypertension

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Event date： 2021.4

Venue：Glasgow, UK
Akasaki Y, Kubozono T, Sakoda T, Ikeda Y, Ohishi M. The effect of health class on blood pressure status in Tarumizu city, Kagoshima prefecture obtained from home blood pressure measurement.

Joint Meeting of the European Society of Hypertension and International Society of Hypertension

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Event date： 2021.4

Venue：Glasgow, UK
Sakoda T., Akasaki Y., Kubozono T., Ikeda Y., Ohishi M. Factor analysis of untreated hypertension from Tarumizu study. International conference

Joint Meeting of the European Society of Hypertension and International Society of Hypertension

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Event date： 2021.4

Venue：Glasgow, UK
Akasaki Y., Kubozono T., Sakoda T., Ikeda Y., Ohishi M. The effect of health class on blood pressure status in Tarumizu city, Kagoshima prefecture obtained from home blood pressure measurement.

Joint Meeting of the European Society of Hypertension and International Society of Hypertension

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Event date： 2021.4

Venue：Glasgow, UK
Akasaki Y., Kubozono T., Higuchi K., Ohishi M. Relationships between anti hypertensive drugs and nocturia: a systematic review. International conference

Joint Meeting of the European Society of Hypertension and International Society of Hypertension

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Event date： 2021.4

Language：English

Venue：Glasgow, UK
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Yamaguchi S, Kuwahata S, Takenaka T, Ohishi M. Day-to-day variability in home blood pressure has an independent association with NT-pro BNP not but with high-sensitivity troponin T.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Uchikado Y, Ikeda Y, Sasaki Y, Akasaki Y, Ohishi M. Angiotensin II type1 receptor /Raf/MEK axis facilitates vascular senescence via dual modification of mitochondrial dynamics and mitophagy.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Kawabata T, Kubozono T, Kawasoe S, Ojima S, Yamaguchi S, Akasaki Y, Kuwahata S, Takenaka T, Ohishi M. Insufficient blood pressure control even with antihypertensive drug is independently associated with high arterial stiffness.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Kawabata T, Kubozono T, Kawasoe S, Ojima S, Yamaguchi S, Akasaki Y, Kuwahata S, Takenaka T, Ohishi M. Post-breakfast tooth brushing is independently associated with decreased risk of occurrence hypertention.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Sasaki Y, Ikeda Y, Uchikado Y, Akasaki A, Ohishi M. Estrogen induces Atg7-indipendent and Rab9-dependent mitophagy which dose not require mitochondrial fission and protects artery from senescence and atherosclerosis.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Yamaguchi S, Kuwahata S, Takenaka T, Ohishi M. Day-to-day variability in home blood pressure is independently associated with liver　stiffness and chronic kidney disease.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Uchikado Y., Ikeda Y., Sasaki Y., Akasaki Y., Ohishi M. Angiotensin II type1 receptor /Raf/MEK axis facilitates vascular senescence via dual modification of mitochondrial dynamics and mitophagy.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Kawabata T., Kubozono T., Kawasoe S., Ojima S., Yamaguchi S., Akasaki Y., Kuwahata S., Takenaka T., Ohishi M. Post-breakfast tooth brushing is independently associated with decreased risk of occurrence hypertention.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Kawabata T., Kubozono T., Kawasoe S., Ojima S., Yamaguchi S., Akasaki Y., Kuwahata S., Takenaka T., Ohishi M. Insufficient blood pressure control even with antihypertensive drug is independently associated with high arterial stiffness.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Sasaki Y., Ikeda Y., Uchikado Y., Akasaki A., Ohishi M. Estrogen induces Atg7-indipendent and Rab9-dependent mitophagy which dose not require mitochondrial fission and protects artery from senescence and atherosclerosis.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Kubozono T., Akasaki Y., Kawasoe S., Ojima S., Kawabata T., Yamaguchi S., Kuwahata S., Takenaka T., Ohishi M. Day-to-day variability in home blood pressure is independently associated with liver stiffness and chronic kidney disease.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
Kubozono T., Akasaki Y., Kawasoe S., Ojima S., Kawabata T., Yamaguchi S., Kuwahata S., Takenaka T., Ohishi M. Day-to-day variability in home blood pressure has an independent association with NT-pro BNP not but with high-sensitivity troponin T.

第85回日本循環器学会学術集会

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Event date： 2021.3

Venue：横浜市
赤﨑雄一, 窪薗琢郎, 牧迫飛雄馬, 桑波田聡, 竹中俊宏, 池田義之, 大石　充. 血圧管理教室による血圧改善への取り組み：鹿児島県垂水市より.

第31回日本老年医学会九州地方会

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Event date： 2021.2
赤﨑雄一, 窪薗琢郎, 牧迫飛雄馬, 桑波田聡, 竹中俊宏, 池田義之, 大石充血圧管理教室による血圧改善への取り組み：鹿児島県垂水市より.

第31回日本老年医学会九州地方会

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Event date： 2021.2
赤﨑雄一, 窪薗琢郎, 牧迫飛雄馬, 桑波田聡, 竹中俊宏, 堀之内貢子, 山口親志, 大石　充. 健康教室が血圧へ与えた影響：鹿児島県垂水市における取り組み.

第56回日本循環器病予防学会学術集会

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Event date： 2020.12

Language：Japanese Presentation type：Oral presentation (general)
中原淳志, 大坪稔拓, 榎園　圭, 二宮雄一, 赤﨑雄一, 市來仁志, 大石　充. 神経調節性失神との鑑別のためにチルト試験が有用であった体位性起立頻脈症候群の一例.

第129回日本循環器学会九州地方会

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Event date： 2020.12

Language：Japanese Presentation type：Oral presentation (general)
窪薗琢郎, 赤﨑雄一, 川添　晋, 前田真由佳, 大野真由, 雉牟田美香, 藤原誠助, 宮川　健, 竹中俊宏, 大石　充. 血圧変動性と心電図との関連.

第32回血圧管理研究会

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. AT1受容体阻害のミトコンドリアクオリティーコントロールによる抗動脈硬化・抗血管老化機構.

第8回 Heart Science Club

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)
Uchikado Y, Ikeda Y, Sasaki Y, Akasaki Y, Ohishi M. Inhibition of Angiotensin II Type 1 Receptor induces dual modification of mitochondrial dynamics and mitophagy via inactivation of RAS/Raf/MEK pathway and contributes vascular anti-senescence. International conference

The American Heart Association’s Scientific Sessions 2020

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Event date： 2020.11

Language：English Presentation type：Oral presentation (general)

Venue：Dallas, USA
窪薗琢郎, 赤﨑雄一, 川添　晋, 川畑孟子, 山口　聡, 小島聡子, 桑波田聡, 竹中俊宏, 大石　充. 一般住民における歯磨きの習慣と高血圧との関連.

第6回日本心臓リハビリテーション学会九州地方会

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)
佐々木雄一, 池田義之, 内門義博, 赤﨑雄一, 大石　充. エストロゲンのSirt1/AMPK軸活性化によるRab9依存性マイトファジーを介した血管老化抑制効果.

第62回日本老年医学会学術集会

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Event date： 2020.8

Language：Japanese Presentation type：Oral presentation (general)
Akasaki Y, Kubozono T, Ikeda Y, Sasaki Y, Uchikado Y, Kuwahata S, Takenaka T, Ohishi M. The Effect of health class on blood pressure status in Tarumizu city, Kagoshima prefecture obtained from home blood pressure measurement.

第84回日本循環器学会学術集会

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Event date： 2020.7 - 2020.8

Language：English Presentation type：Oral presentation (general)
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Kuwahata S, Takenaka T, Ohishi M The relationship between home blood pressure and temperature in the general population.

第84回日本循環器学会学術集会

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Event date： 2020.7 - 2020.8

Language：English Presentation type：Oral presentation (general)
Kubozono T, Akasaki Y, Kawasoe S, Ojima S, Kawabata T, Kuwahata S, Takenaka T, Ohishi M Clinical significance of the urinary sodium-to-potassium ratio for home blood pressure.

第84回日本循環器学会学術集会

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Event date： 2020.7 - 2020.8

Language：English Presentation type：Oral presentation (general)
Uchikado Y, Ikeda Y, Sasaki Y, Akasaki Y, Ohishi M. Angiotensin II type1 receptor-mediated mitochondrial fission and suppression of mitophagy are crucial role in vascular senescence and arteriosclerosis. International conference

Basic Cardiovascular Sciences 2020 Scientific Sessions

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Event date： 2020.7

Language：English Presentation type：Oral presentation (general)

Venue：Chicago, USA
窪薗琢郎, 赤﨑雄一, 川添　晋, 小島聡子, 川畑孟子，桑波田聡, 竹中俊宏, 大石　充. 地域一般住民における家庭血圧測定及び高血圧管理教室による降圧効果の検討.

第26回日本心臓リハビリテーション学会学術集会

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Event date： 2020.7

Language：Japanese Presentation type：Oral presentation (general)
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. ARBはRab9依存性mitophagyを亢進させることで血管老化を抑制する.

第52回日本動脈硬化学会総会・学術集会

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Event date： 2020.7

Language：Japanese Presentation type：Oral presentation (general)
大野真由, 前田真由佳, 窪薗琢郎, 橘圭一郎, 赤﨑雄一, 堀之内貢子, 山口親志, 雉子牟田美香, 藤原誠助, 宮川　健, 桑波田聡, 竹中俊宏, 大石　充. 継続的な家庭血圧測定における健康教室が与える影響.

第62回鹿児島県公衆衛生学会

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Event date： 2020.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：書面開催のみ
内門義博, 池田義之, 佐々木雄一, 赤﨑雄一, 大石　充. ミトコンドリアダイナミクスとマイトファジーは血管老化および動脈硬化予防において重要な役割を果たす.

第30回日本老年医学会九州地方会

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Event date： 2020.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：誌上開催
池田義之, 佐々木健, 桑波田聡, 今村正和, 赤﨑雄一, 大石　充. 高齢者高血圧治療における患者の理解や患者-医師間の満足度に関する検討.

第30回日本老年医学会九州地方会

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Event date： 2020.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：誌上開催
佐々木雄一, 池田義之, 内門義博, 赤﨑雄一, 大石　充. エストロゲンのマイトファジーを介した抗血管老化作用.

第16回 Cardiovascular Translational Research Conference

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Event date： 2020.1

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡市
佐々木雄一，池田義之，内門義博，赤﨑雄一，大石　充. エストロゲンはSirt1/LKB1/AMPK軸活性化によるRab9依存性マイトファジーを介して血管老化を抑制する.

第23回日本心血管内分泌代謝学会学術集会

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Event date： 2019.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸
内門義博，池田義之，佐々木雄一，赤﨑雄一，大石　充. ox-LDLやAGEはAngiotensinⅡTypeⅠreceptor signalによるmitochondrial ?ssionを介して血管老化を来す.

第27回日本血管生物医学会学術集会

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Event date： 2019.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸
Uchikado Y, Ikeda Y, Sasaki Y, Akasaki Y, Ohishi M. Metabolic stress causes mitochondrial dysfunction and vascular senescence via angiotensin II type I receptor signal / Rho kinase induced mitochondrial fission. International conference

American Heart Association Resuscitation Science Symposium 2019

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Event date： 2019.11

Language：English Presentation type：Oral presentation (general)

Venue：Philadelphia, USA
Sasaki Y, Ikeda Y, Uchikado Y, Akasaki Y, Ohishi M. Alternative autophagy is the predominant form of autophagy in estrogen-mediated mitochondrial quality control in artery. International conference

American Heart Association Scientific Sessions 2019

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Event date： 2019.11

Language：English Presentation type：Oral presentation (general)

Venue：Philadelphia, USA
窪薗琢郎，赤﨑雄一，川添　晋，牧迫飛雄馬，桑波田聡，竹中俊宏，堀之内貢子，山口親志，雉牟田美香，藤原誠助，宮川　健，大石　充. 地域コホート研究における家庭血圧と尿ナトリウム/カリウム比の関連性に関する研究.

第31回血圧管理研究会

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Event date： 2019.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：京都
赤﨑雄一, 池田義之, 佐々木健, 桑波田総, 今村正和, 大石　充. 高血圧治療における患者の理解や患者－医師間の満足度は前期高齢者と後期高齢者で異なる.

第42回日本高血圧学会総会

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Event date： 2019.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京
内門義博，池田義之，佐々木雄一，赤﨑雄一，大石　充. ox-LDLによる血管老化にAngiotensinⅡTypeⅠ受容体を介したmitochondrial ?ssionは重要な役割を果たす.

第67回日本心臓病学会学術集会

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Event date： 2019.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：名古屋
Uchikado Y, Ikeda Y, Sasaki Y, Akasaki Y, Ohishi M. Oxidized low density lipoprotein and angiotensin II causes vascular senescence via AT1R signal-mediate mitochondrial ?ssion. International conference

AHA Basic Cardiovascular Science 2019

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Event date： 2019.7

Language：English Presentation type：Oral presentation (general)

Venue：Boston, USA
内門義博，池田義之，佐々木雄一，赤﨑雄一，大石　充. ox-LDLやAGEによる血管老化にAngiotensinII type1受容体を介したmitochondrial ?ssionは重要な役割を果たす.

第51回日本動脈硬化学会総会・学術集会

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Event date： 2019.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：京都
赤﨑雄一，窪薗琢郎，池田義之，大石　充. CAVI上昇は，血圧変動の独立した危険因子である：超高齢者社会を迎えた鹿児島県垂水市における健康調査の結果から.

第51回日本動脈硬化学会総会・学術集会

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Event date： 2019.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：京都
赤﨑雄一，窪薗琢郎，池田義之，富岡一俊，桑波田聡，竹中俊宏，牧迫飛雄馬，大石　充. 血圧・血圧変動とサルコペニア・軽度認知機能障害の関係：垂水研究.

第61回日本老年医学会学術集会

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Event date： 2019.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：仙台市
内門義博，池田義之，佐々木雄一，赤﨑雄一，大石　充. 生活習慣病による血管老化にAngiotensin2 Type1受容体を介したmitochondrial ?ssionは重要な役割を果たす.

第61回日本老年医学会学術集会

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Event date： 2019.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：仙台市
窪薗琢郎，牧迫飛雄馬，赤﨑雄一，小島聡子，桑波田聡，竹中俊宏，大石　充. 高齢者における学歴と血管機能に関する研究.

第61回日本老年医学会学術集会

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Event date： 2019.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：仙台市
池田義之，佐々木健，桑波田聡，今村正和，赤﨑雄一，大石　充. 高血圧治療における患者の理解や患者―医師間の満足度は前期高齢者と後期高齢者で異なる特徴をもつ.

第61回日本老年医学会学術集会

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Event date： 2019.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：仙台市
窪薗琢郎，赤﨑雄一，小島聡子，牧迫飛雄馬，桑波田聡，竹中俊宏，大石　充. 睡眠状況と血圧変動に関する検討.

第55回日本循環器予防学術総会

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Event date： 2019.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：久留米市
赤﨑雄一，窪薗琢郎，杉浦　剛，牧迫飛雄馬，田平隆行，桑波田聡，竹中俊宏，大石　充. 未治療高血圧の要因分析：垂水研究からの考察.

第8回臨床高血圧フォーラム

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Event date： 2019.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：久留米市
赤﨑雄一，窪薗琢郎，杉浦　剛，牧迫飛雄馬，田平隆行，桑波田聡，竹中俊宏，大石　充. コントロール不良高血圧の要因分析：垂水研究からの考察.

第8回臨床高血圧フォーラム

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Event date： 2019.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：久留米市
Uchikado Y, Ikeda Y, Sasaki Y, Akasaki Y, Higuchi K, Ohishi M. Metabolic stress and angiotensin II causes vascular senescence via AT1R signal-mediate mitochondrial fission.

第83回日本循環器学会学術集会

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Event date： 2019.3

Language：English Presentation type：Oral presentation (general)

Venue：神奈川
Sasaki Y, Ikeda Y, Akasaki Y, Uchikado Y, Higuchi K, Ohishi M. Estrogen/Sirt1/LKB1/AMPK axis plays a crucial role in mediating Rab9-dependent mitophagy and retarding arterial senescence.

第83回日本循環器学会学術集会

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Event date： 2019.3

Language：English Presentation type：Oral presentation (general)

Venue：神奈川
Akasaki Y, Ikeda Y, Uchikado Y, Sasaki Y, Higuchi K, Ohishi M. Metabolic stress causes sarcopenia via angiotensin II type I receptor signal-induced mitochondrial fission.

第83回日本循環器学会学術集会

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Event date： 2019.3

Language：English Presentation type：Oral presentation (general)

Venue：神奈川
Akasaki Y, Ikeda Y, Uchikado Y, Sasaki Y, Higuchi K, Ohishi M. Metabolic stress evokes muscular mitochondrial dysfunction and sarcopenia via angiotensin II type I receptor signal induced mitochondrial fission. International conference

American Heart Association Scientific Sessions 2018

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Event date： 2018.11

Language：English Presentation type：Oral presentation (general)

Venue：Chicago, USA
Uchikado Y, Ikeda Y, Sasaki Y, Akasaki Y, Ohishi M. Metabolic stress evokes mitochondrial dysfunction and vascular senescence via mitochondrial fission. International conference

The 2nd JCS Council Forum on Basic Cardiovascular Research

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Event date： 2018.9

Language：English Presentation type：Oral presentation (general)

Venue： Nara, Japan
Akasaki Y, Ikeda Y, Sasaki T, Kuwahata S, Sasaki Y, Ohishi M. Questionnaire survey from the viewpoint of concordance in patient and physician satisfaction concerning hypertensive treatment in elderly patients (patients voice study). International conference

ISH 2018

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Event date： 2018.9

Language：English Presentation type：Oral presentation (general)

Venue： Beijing, China
赤﨑雄一, 大石　充. シンポジウム2. 血圧変動評価と臓器障害. 高齢者における血圧変動と心血管疾患および身体機能の関係.

第41回日本高血圧学会総会

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Event date： 2018.9

Language：Japanese Presentation type：Symposium, workshop panel (nominated)

Venue：北海道旭川市
赤﨑雄一, 池田義之, 大石　充. 超高齢化社会を迎えた鹿児島県垂水市における高齢者の血圧の現状.

第41回日本高血圧学会総会

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：北海道旭川市
佐々木雄一, 池田義之, 赤﨑雄一, 内門義博, 樋口公嗣, 宮田昌明, 大石　充. エストロゲンのRab9依存性マイトファジーを介した血管老化抑制効果.

第50回日本動脈硬化学会総会・学術集会

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Event date： 2018.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：大阪
Sasaki Y, Ikeda Y, Akasaki Y, Uchikado Y, Ohishi M. Estrogen Protects Artery from Senescence via Sirt1/AMPK/Rab9-mediated Mitophagy. International conference

AHA Basic Cardiovascular Science 2018

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Event date： 2018.7

Language：English Presentation type：Oral presentation (general)

Venue：San Antonio, USA
池田義之, 佐々木健, 桑波田聡, 今村正和, 浜田知久馬, 赤﨑雄一, 大石　充. 高齢高血圧患者における患者満足度と医師満足度の対比研究.

第60回日本老年医学会学術集会

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Event date： 2018.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：京都
佐々木雄一, 池田義之, 赤﨑雄一, 内門義博, 樋口公嗣, 宮田昌明, 大石　充. エストロゲンはrab9依存性マイトファジーを介して血管老化及び動脈硬化に保護的に働く.

第124回日本循環器学会九州地方会

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Event date： 2018.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：鹿児島
川畑孟子, 桑波田聡, 竹中俊宏, 川島吉博, 大重剛志, 安部　智, 牧迫飛雄馬, 赤﨑雄一, 窪薗琢郎, 大石　充. 垂水地区における高齢者高血圧患者の特徴：垂水研究からの報告.

第124回日本循環器学会九州地方会

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Event date： 2018.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：鹿児島
佐々木雄一, 池田義之, 赤﨑雄一, 内門義博, 樋口公嗣, 大石　充. エストロゲンはRab9依存性マイトファジーを介して細胞老化を抑制する

第22回日本心血管内分泌代謝学会学術集会

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Event date： 2018.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：宮崎
牛飼純平, 赤﨑雄一, 宮田昌明, 牧瀬洋一, 黒田正幸, 横手幸太郎, 大石　充. 低HDLと角膜混濁から魚眼病と診断した姉妹

医学生・研修医の日本内科学会ことはじめ2018京都

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Event date： 2018.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：京都
池田義之, 佐々木健, 桑波田聡, 今村正和, 浜田知久馬, 赤﨑雄一, 大石　充. 高齢高血圧患者における降圧治療強化前後の患者満足度と医師満足度の対比研究.

第115回日本内科学会総会・講演会

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Event date： 2018.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：京都
Sasaki Y, Ikeda Y, Iwabayashi M, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Inhibition of angiotensin II type 1 receptor retards development of cellular senescence and atherosclerosis via augmentation of Rab9-dependent mitophagy.

第82回日本循環器学会学術集会

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Event date： 2018.3

Language：English Presentation type：Oral presentation (general)

Venue：大阪
Sasaki Y, Ikeda Y, Iwabayashi M, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Estrogen maintains mitochondrial function and retards vascular senescence via Rab9-dependent mitophagy.

第82回日本循環器学会学術集会

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Event date： 2018.3

Language：English Presentation type：Oral presentation (general)

Venue：大阪
池田義之, 佐々木健, 桑波田聡, 今村正和, 浜田知久馬, 赤﨑雄一, 大石　充. 高齢高血圧患者における患者満足度と医師満足度の対比研究.

第28回日本老年医学会九州地方会

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Event date： 2018.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：沖縄
Sasaki Y, Ikeda Y, Iwabayashi M, Miyauchi T, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Estrogen-induced alternative autophagy plays a crucial role in maintaining mitochondrial function and retarding vascular senescence.

第1回日本循環器学会基礎フォーラム

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Event date： 2018.1

Language：English Presentation type：Oral presentation (general)

Venue：東京
佐々木雄一, 池田義之, 宮内孝浩, 岩林正明, 赤﨑雄一, 樋口公嗣, 宮田昌明, 大石　充. 選択的エストロゲン作動薬 (SERM) は, 閉経モデルマウスにおける血管老化および動脈硬化の進展を抑制する.

第21回日本心血管内分泌代謝学会学術集会

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Event date： 2017.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：大阪
Sasaki Y, Ikeda Y, Iwabayashi M, Akasaki Y, Higuchi K, Miyata M, Ohishi M Estrogen-induced alternative autophagy plays a crucial role in protecting artery from senescence and atherosclerosis. International conference

American Heart Asociation 2017

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Event date： 2017.11

Language：English Presentation type：Oral presentation (general)

Venue： Anaheim, USA
佐々木雄一, 池田義之, 岩林正明, 赤﨑雄一, 樋口公嗣, 宮田昌明, 大石　充. ミトコンドリアダイナミクス不均衡は, アンギオテンシIIによる血管障害に対する有効な治療ターゲットとなる.

第53回高血圧関連疾患モデル学会学術総会

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Event date： 2017.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡
宮田昌明, 金竹茂純, 丸口由紀子, 上ノ町仁, 加治屋昌子, 赤﨑雄一, 池田義之, 大石　充. SGLT2阻害薬の腎機能に対する作用.

第40回日本高血圧学会総会

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Event date： 2017.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：愛媛
池田義之, 佐々木健, 桑波田聡, 今村正和, 浜田知久馬, 赤﨑雄一, 大石　充. 個別治療を目指した高齢高血圧患者における降圧薬使用時の患者満足度と医師満足度の対比研究.

第40回日本高血圧学会総会

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Event date： 2017.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：愛媛
板倉　進, 宮田昌明, 黒田　篤, 瀬戸口学, 楠本敦旨, 鉾之原大助, 赤﨑雄一, 大石　充. 高齢者における口腔機能としての咬合の安定性と高血圧を含めた併存疾患との関連性.

第40回日本高血圧学会総会

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Event date： 2017.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：愛媛
赤﨑雄一, 小島聡子, 窪薗琢郎, 川添　晋, 宮田昌明, 吉福士郎, 宮原広典, 前之原茂穂, 大石　充. 形態的及び機能的動脈硬化に関連する因子の検討.

第40回日本高血圧学会総会

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Event date： 2017.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：愛媛
Sasaki Y, Ikeda Y, Iwabayashi M, Miyauchi T, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Selective estrogen receptor modulator retards arterial senescence and atherosclerosis via upregulation of eNOS/Sirt-1 pathway in post-menopause model mouse. International conference

The 8th Congress of the International Society for Gender Medicine

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Event date： 2017.9

Language：English Presentation type：Oral presentation (general)
Ikeda Y, Sasaki T, Kuwahata S, Akasaki Y, Hamada C, OhishiM. Switching insufficient hypotensive monotherapy to ARB/CCB combination tablet in elderly patients increases both patient and physician satisfaction rates and contributes better patient-physician concordance (Patients Voice study). International conference

AHA Council on Hypertension 2017

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Event date： 2017.9

Language：English Presentation type：Oral presentation (general)

Venue：San Francisco, USA
Ikeda Y, Iwabayashi M, Sasaki Y, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Renin-angiotensin signal develops arterial senescence and atherosclerosis via modulation of mitochondrial dynamics. International conference

AHA Council on Hypertension 2017

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Event date： 2017.9

Language：English Presentation type：Oral presentation (general)

Venue：San Francisco, USA
佐々木雄一, 池田義之, 神田大輔, 内匠拓朗, 小瀬戸一平, 薗田剛嗣, 赤﨑雄一, 宮田昌明, 大石　充. 重症虚血肢膝下動脈病変に対して救肢のため冠動脈ステントを留置し長期的に有効であった1 例.

日本内科学会第318回九州地方会

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Event date： 2017.8

Language：Japanese Presentation type：Oral presentation (general)

Venue：鹿児島
池田義之, 岩林正明, 佐々木雄一, 赤﨑雄一, 宮田昌明, 大石　充. ミトコンドリアダイナミクスの血管老化および動脈硬化に及ぼす影響.

第49回日本動脈硬化学会総会・学術集会

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Event date： 2017.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：広島
池田義之, 岩林正明, 佐々木雄一, 赤﨑雄一, 樋口公嗣, 宮田昌明, 大石　充. ミトコンドリアダイナミクスの動脈硬化や血管老化に及ぼす影響に関する検討.

第59回日本老年医学会学術集会

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Event date： 2017.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：名古屋
Sasaki Y, Ikeda Y, Iwabayashi M, Miyauchi T, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Featured research session 9. Estrogen retards arterial senescence and atherosclerosis through sirt1-mediated alternative autophagy.

第81回日本循環器学会総会・学術集会

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Event date： 2017.3

Language：English Presentation type：Oral presentation (general)

Venue：石川
Ikeda Y, Iwabayashi M, Sasaki Y, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Mitochondrial dynamics plays a role in the effect of renin-angiotensin signal on arterial senescence and atherosclerosis.

第81回日本循環器学会総会・学術集会

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Event date： 2017.3

Language：English Presentation type：Oral presentation (general)

Venue：石川
神田大輔, 池田義之, 佐々木雄一, 内匠拓朗, 小瀬戸一平, 薗田剛嗣, 赤﨑雄一, 宮田昌明, 大石　充. 重症虚血肢膝下動脈病変に対する冠動脈ステント留置が長期的に有効であった高齢者1症例.

第27回日本老年医学会九州地方会

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Event date： 2017.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡
佐々木雄一, 池田義之, 岩林正明, 宮内孝浩, 赤﨑雄一, 樋口公嗣, 宮田昌明, 大石　充. 閉経に伴う血管老化進展にeNOS-Sirt1系低下が関与している：閉経モデルマウスを用いた検討.

第121回日本循環器学会九州地方会

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Event date： 2016.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：鹿児島
Ikeda Y, Iwabayashi M, Sasaki Y, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Mitochondrial fusion plays a crucial role in the effect of renin-angiotensin signal inhibition on retarding arterial senescence and atherosclerosis. International conference

AHA Scientific Sessions 2016

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Event date： 2016.11

Language：English

Venue：New Orleands, USA
Ikeda Y, Iwabayashi M, Sasaki Y, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Inhibition of renin-angiotensin signal retards arterial senescence and development of atherosclerosis in apolipoprotein E knockout mice via induction of alternative autophagy. International conference

International Hypertension Conference (ISH) 2016

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Event date： 2016.9

Language：English

Venue：Seoul, Korea
赤﨑雄一, 池田義之, 佐々木雄一, 木原浩一, 剣田昌伸, 宮田昌明, 大石　充. 排尿時の嘔気嘔吐発作を認めた悪性褐色細胞腫の一例.

第39回日本高血圧学会総会

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Event date： 2016.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：宮城
Ikeda Y, Iwabayashi M, Sasaki Y, Akasaki Y, Higuchi K, Miyata M, Ohishi M. Alternative autophagy plays a role in the effect of ras-inhibition on arterial senescence and arteriosclerosis. International conference

America Heart Association Basic Cardiovascular Science 2016

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Event date： 2016.7

Language：English

Venue：Phoenix, USA
佐々木雄一, 池田義之, 岩林正明, 宮内孝浩, 赤﨑雄一, 樋口公嗣, 宮田昌明, 大石　充. 閉経に伴う血管老化進展にオートファジーは重要な役割を果たしている.

第48回日本動脈硬化学会総会・学術集会

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Event date： 2016.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京
池田義之, 岩林正明, 佐々木雄一, 赤﨑雄一, 樋口公嗣, 宮田昌明, 大石　充. アンギオテンシンII Type1受容体阻害によるミトコンドリアダイナミクスを介した抗血管老化作用.

第16回日本抗加齢医学会総会

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Event date： 2016.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：横浜
赤﨑雄一, 宮内孝浩, 窪薗琢郎, 川添　晋, 池田義之, 佐々木雄一, 宮田昌明, 大石　充. 上腕－足首間脈波伝播速度による心血管病患者の左室拡張機能障害の予測.

第16回臨床脈波研究会

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Event date： 2016.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京
赤﨑雄一, 宮内孝浩, 窪薗琢郎, 川添　晋, 池田義之, 佐々木雄一, 宮田昌明, 大石　充. 上腕－足首間脈波伝播速度による心血管病患者の左室拡張機能障害の予測.

第26回日本老年医学会九州地方会

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Event date： 2016.3

Language：English Presentation type：Oral presentation (general)

Venue：鹿児島
Ikeda Y, Iwabayashi M, Sasaki Y, Akasaki Y, Miyata M, Sadoshima J, Ohishi M. Inhibition of renin-angiotensin-aldosterone signal retards arterial senescence and development of atherosclerosis via induction of alternative autophagy.

第80回日本循環器学会学術集会

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Event date： 2016.3

Language：Japanese

Venue：宮城
Sasaki Y, Ikeda Y, Iwabayashi M, Miyauchi T, Akasaki Y, Miyata M, Ohishi M. Autophagy plays a role in the etiology of post menopause-induced arterial senescence and atherosclerosis.

第80回日本循環器学会学術集会

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Event date： 2016.3

Language：Japanese

Venue：宮城
Iwabayashi M, Ikeda Y, Sasaki Y, Akasaki Y, Miyata M, Sadoshima J , Ohishi M. Inhibition of renin-angiotensin signal retards arterial senescence and development of atherosclerosis in apolipoprotein eknockout mice via induction of alternative autophagy. International conference

AHA Scientific Sessions 2015

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Event date： 2015.11

Language：English

Venue：Orlando, USA
佐々木雄一, 池田義之, 岩林正明, 宮内孝浩, 赤﨑雄一, 宮田昌明, 大石　充. オートファジーは閉経に伴う血管老化進展に重要な役割を果たしている－閉経モデルマウスを用いた検討－.

第51回高血圧関連疾患モデル学会学術総会

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Event date： 2015.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：大阪
Iwabayashi M, Ikeda Y, Sasaki Y, Akasaki Y, Miyata M, Sadoshima J , Ohishi M. Inhibition of renin-angiotensin signal retards arterial senescence and development of atherosclerosis in apolipoprotein eknockout mice via induction of alternative autophagy. International conference

AHA Scientific Sessions 2015

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Event date： 2015.11

Language：English Presentation type：Oral presentation (general)

Venue： Orlando, USA
佐々木雄一, 池田義之, 岩林正明, 赤﨑雄一, 宮田昌明, 大石　充. アンギオテンシンII Type 1受容体抑制が高脂血症モデルマウスにおいて血管老化を抑制する機序に関する検討.

第22回九州血液血管研究会

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Event date： 2015.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡
赤﨑雄一, 池田義之, 佐々木雄一, 宮内孝浩, 窪薗琢郎, 宮田昌明, 大石　充. 上腕－足首間脈波伝搬速度の増加は, 心血管病患者の左室拡張機能障害を予測した.

第38回日本高血圧学会総会

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Event date： 2015.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：愛媛
Ikeda Y, Miyauchi T, Iwabayashi M, Sasaki Y, Akasaki Y, Miyata M, Ohishi M. Selective estrogen receptor modulator retards arterial senescence and atherosclerosis via upregulation of sirt-1 and autophagy in post-menopause model mouse. International conference

AHA Basic Cardiovascular Science (BCVS) 2015

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Event date： 2015.7

Language：English

Venue： New Orleans, USA
宮内孝浩, 池田義之, 赤﨑雄一, 岩林正明, 佐々木雄一, 宮田昌明, 大石　充. 選択的エストロゲン作動薬 (SERM) は, 閉経モデルマウスにおける血管老化および動脈硬化の進展を抑制する.

第47回日本動脈硬化学会総会・学術集会

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Event date： 2015.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：宮城
Ikeda Y, Miyauchi T, Iwabayashi M, Sasaki Y, Akasaki Y, Miyata M, Ohishi M. Selective estrogen receptor modulator retards arterial senescence and atherosclerosis via upregulation of sirt-1 and autophagy in post-menopause model mouse. International conference

AHA Basic Cardiovascular Science (BCVS) 2015

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Event date： 2015.7

Language：English Presentation type：Oral presentation (general)

Venue： New Orleans, USA
宮内孝浩, 池田義之, 赤﨑雄一, 岩林正明, 佐々木雄一,宮田昌明, 大石　充. 選択的エストロゲン調節薬(SERM)は閉経モデルマウスにおける血管老化および動脈硬化の進展を抑制する.

第57回日本老年医学会学術集会

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Event date： 2015.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：神奈川
上坊翔太, 吉村あきの, 内匠拓朗, 赤﨑雄一, 宮田昌明, 大石　充. 成長ホルモン分泌不全に左室機能不全を合併した一例.

第118回日本循環器学会九州地方会

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Event date： 2015.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡
池田義之, 宮内孝浩, 岩林正明, 佐々木雄一, 赤崎雄一, 宮田昌明, 大石　充.ｖ選択的エストロゲン受容体モジュレーター (SERM) は閉経モデルマウスにおける血管老化および動脈硬化の進展を抑制する.

第15回日本抗加齢医学会総会

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Event date： 2015.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡
Akasaki Y, Ikeda Y, Miyauchi T, Kubozono T, Miyata M, Ohishi M. Increased cardio-Ankle vascular index predicts left ventricular diastolic dysfunction.

第79回日本循環器学会総会・学術集会

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Event date： 2015.4

Language：Japanese
Miyauchi T, Ikeda Y, Akasaki Y, Iwabayashi M, Sasaki Y, Miyata M, Ohishi M. Selective estrogen receptor modulator retards arterial senescence and atherosclerosis via activation of eNOS/Sirt-1 pathway in post-menopause model mouse.

第79回日本循環器学会総会・学術集会

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Event date： 2015.4

Language：Japanese

Venue：大阪
Akasaki Y, Ikeda Y, Miyauchi T, Kubozono T, Miyata M, Ohishi M. Increased cardio-Ankle vascular index predicts left ventricular diastolic dysfunction.

第79回日本循環器学会総会・学術集会

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Event date： 2015.4

Language：English Presentation type：Oral presentation (general)

Venue：大阪
宮内孝浩, 赤﨑雄一, 池田義之, 宮田昌明, 大石　充. 長期食事管理された後期高齢者の脈波伝搬速度.

第112回日本内科学会総会・講演会

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Event date： 2015.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：京都
Miyauchi T, Ikeda Y, Akasaki Y, Iwabayashi M, Sasaki Y, Miyata M, Ohishi M. Selective estrogen receptor modulator retards arterial senescence and atherosclerosis via activation of eNOS/Sirt-1 pathway in post-menopause model mouse.

第79回日本循環器学会総会・学術集会

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Event date： 2015.4

Language：English Presentation type：Oral presentation (general)

Venue：大阪
岩林正明, 池田義之, 宮内孝浩, 赤崎雄一, 佐々木雄一, 宮田昌明, 大石　充. アンギオテンシンII Type 1受容体の抑制はSirt3発現亢進を介して高脂血症モデルマウスの血管老化を抑制する.

第25回日本老年医学会九州地方会

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Event date： 2015.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡
宮内孝浩, 池田義之, 赤﨑雄一, 岩林正明, 佐々木雄一,宮田昌明, 大石　充. 選択的エストロゲン作動薬 (SERM) は閉経モデルマウスにおける血管老化および動脈硬化の進展を抑制する.

第2回臨床骨ネットワーク研究会

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Event date： 2015.2

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京
Miyauchi T, Ikeda Y, Akasaki Y, Iwabayashi M, Sasaki Y, Miyata M, Ohishi M. Selective estrogen receptor modulator retards arterial senescence and atherosclerosis through restoration of down-regulated Sirt-1 in post-menopause model mouse. International conference

American Heart Association (AHA) American Heart Association (AHA)

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Event date： 2014.11

Language：English

Venue：USA

国際学会
宮内孝浩, 有村洋, 赤﨑雄一, 窪薗琢郎, 池田義之, 宮田昌明, 西尾善彦, 大石充. 先端巨大症患者の経蝶形骨洞手術前後評価におけるCAVIの有用性. International conference

第37回日本高血圧学会総会第37回日本高血圧学会総会

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Event date： 2014.10

Language：English

Venue：神奈川

国際学会
Akasaki Y, Miyauchi T, Kubozono T, Miyata M, Ohishi M. Increased arterial stiffness assessed by brachial-ankle pulse wave velocity is an independent risk factor of left ventricular diastolic dysfunction. International conference

Pulse of Asia 2014 Pulse of Asia 2014

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Event date： 2014.6

Language：English

Venue：ギリシャ

国際学会
池田義之, 宮田昌明, 赤崎雄一, 宮内孝浩, 大石充. アンギオテンシンII Type 1受容体の抑制は高脂血症モデルマウスの血管老化を抑制する.

第56回日本老年医学会学術集会第56回日本老年医学会学術集会

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Event date： 2014.6

Language：Japanese

Venue：福岡

国内学会
Miyauchi T, Arimura H, Akasaki Y, Kubozono T, Miyata M, Nishio Y, Ohishi M. Changes of cardiovascular disease parameters in patients with acromegaly after transsphenodial surgery. International conference

Joint Meeting Europian Society of Hypertension and International Society Hypertension Joint Meeting Europian Society of Hypertension and International Society Hypertension

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Event date： 2014.6

Language：English

Venue：ギリシャ

国際学会
Akasaki Y, Miyauchi T, Kubozono T, Miyata M, Ohishi M. Increased arterial stiffness assessed by cardio-ankle vascular index is an independent risk factor of left ventricular diastolic dysfunction. International conference

Joint Meeting Europian Society of Hypertension and International Society Hypertension Joint Meeting Europian Society of Hypertension and International Society Hypertension

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Event date： 2014.6

Language：English

Venue：ギリシャ

国際学会
Miyata M, Akasaki Y, Miyauchi T, Ikeda Y, Ohishi M. Preventive effect of thermal therapy on heart failure due to pressure overload. International conference

39th World Congress of International Scientific Meeting of Medical Hydrology and Climatology 39th World Congress of International Scientific Meeting of Medical Hydrology and Climatology

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Event date： 2014.5

Language：English

Venue：京都

国際学会
宮内孝浩, 赤崎雄一, 池田義之, 宮田昌明, 大石充. 長期管理された後期高齢者の脈波伝播速度.

第5回九州実地臨床高血圧研究会第5回九州実地臨床高血圧研究会

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Event date： 2014.5

Language：Japanese

Venue：福岡

国内学会
宮内孝浩, 赤﨑雄一, 大石充. 長期食事管理された後期高齢者の脈波伝播速度.

第24回日本老年医学会九州地方会第24回日本老年医学会九州地方会

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Event date： 2014.3

Language：Japanese

Venue：福岡

国内学会
宮田昌明, 赤﨑雄一, 宮内孝浩, 濱崎秀一, 大石　充, KACT-MetS研究者メタボリックシンドローム合併高血圧症患者におけるバルサルタンのPAI-1低下作用の性差: KACT-MetS研究サブ解析.

第61回日本心臓病学会学術集会

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Event date： 2013.9

Language：Japanese

Venue：熊本
宮内孝浩, 宮田昌明, 池田義之, 赤﨑雄一, 濵田成郷, 白澤尚宏, 古庄優子, 濱崎秀一, 鄭　忠和, 大石　充. 和温療法の血管新生作用におけるHeat Shock Protein 90 とAkt-eNOSシグナル伝達の関与: 下肢虚血モデルマウスを用いた検討.

第9回西日本血管・機能研究会　

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Event date： 2013.8

Language：English Presentation type：Oral presentation (general)

Venue：福岡
宮内孝浩, 宮田昌明, 池田義之, 赤﨑雄一, 濵田成郷, 白澤尚宏, 古庄優子, 濱崎秀一, 鄭　忠和, 大石　充. 和温療法の血管新生作用におけるHeat Shock Protein 90 とAkt-eNOSシグナル伝達の関与: 下肢虚血モデルマウスを用いた検討.

第10回西日本血管・機能研究会

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Event date： 2013.8

Language：English
Miyauchi T, Miyata M, Ikeda Y, Akasaki Y, Hamada N, Shirasawa T, Eto H, Hamasaki S, Tei C. Circulation Journal Award Session: Waon therapy up regulate the hsp90 and leads to angiogenesis through Akt-eNOS pathway in a mouse model of hindlimb ischemia.

第77回日本循環器学会総会・学術集会

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Event date： 2013.3

Language：English
Akasaki Y, Miyata M, Ikeda Y, Miyauchi T, Tei C Molecular Mechanism of Waon Therapy on Cardiovascular Disease

第76回日本循環器学会総会第76回日本循環器学会総会

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Event date： 2012.3

Language：Japanese

Venue：福岡

国内学会
Sasaki Yuichi, Ikeda Yoshiyuki, Uchikado Yoshihiro, Akasaki Yuichi, Ohishi Mitsuru エストロゲンはミトコンドリアの分裂を必要としないAtg7非依存性およびRab9依存性のマイトファジーを誘導し、動脈を老化と動脈硬化から守る(Estrogen Induces Atg7-indipendent and Rab9-dependent Mitophagy Which Dose not Require Mitochondrial Fission and Protects Artery from Senescence and Atherosclerosis)

日本循環器学会学術集会抄録集 2021.3 (一社)日本循環器学会

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Uchikado Yoshihiro, Ikeda Yoshiyuki, Sasaki Yuichi, Akasaki Yuichi, Ohishi Mitsuru アンジオテンシンIIタイプ1受容体/Raf/MEK Axisはミトコンドリアダイナミクスとマイトファジーの二重の修飾を介して血管退行を促す(Angiotensin II Type1 Receptor/Raf/MEK Axis Facilitates Vascular Senescence via Dual Modification of Mitochondrial Dynamics and Mitophagy)

日本循環器学会学術集会抄録集 2021.3 (一社)日本循環器学会

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Uebo Shota, Ikeda Yoshiyuki, Sasaki Yuichi, Uchikado Yoshihiro, Akasaki Yuichi, Kubozono Takuro, Ohishi Mitsuru Rab9-dependent Mitophagy is a Comprehensive Therapeutic Target in Cardiovascular Disorders and Sarcopenia in Postmenopausal Women(タイトル和訳中)

日本循環器学会学術集会抄録集 2025.3 (一社)日本循環器学会

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Uebo Shota, Ikeda Yoshiyuki, Sasaki Yuichi, Uchikado Yoshihiro, Akasaki Yuichi, Kubozono Takuro, Ohishi Mitsuru Rab9-dependent Mitophagy is a Comprehensive Therapeutic Target in Cardiovascular Disorders and Sarcopenia in Postmenopausal Women(タイトル和訳中)

日本循環器学会学術集会抄録集 2025.3 (一社)日本循環器学会

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Sasaki Yuichi, Ikeda Yoshiyuki, Uchikado Yoshihiro, Akasaki Yuichi, Ohishi Mitsuru エストロゲンはミトコンドリアの分裂を必要としないAtg7非依存性およびRab9依存性のマイトファジーを誘導し、動脈を老化と動脈硬化から守る(Estrogen Induces Atg7-indipendent and Rab9-dependent Mitophagy Which Dose not Require Mitochondrial Fission and Protects Artery from Senescence and Atherosclerosis)

日本循環器学会学術集会抄録集 2021.3 (一社)日本循環器学会

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Uchikado Yoshihiro, Ikeda Yoshiyuki, Sasaki Yuichi, Akasaki Yuichi, Ohishi Mitsuru アンジオテンシンIIタイプ1受容体/Raf/MEK Axisはミトコンドリアダイナミクスとマイトファジーの二重の修飾を介して血管退行を促す(Angiotensin II Type1 Receptor/Raf/MEK Axis Facilitates Vascular Senescence via Dual Modification of Mitochondrial Dynamics and Mitophagy)

日本循環器学会学術集会抄録集 2021.3 (一社)日本循環器学会

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Awards

第16回臨床脈波研究会優秀賞.

2016.6 臨床脈波研究会上腕－足首間脈波伝播速度による心血管病患者の左室拡張機能障害の予測.

赤﨑雄一

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Award type：Award from Japanese society, conference, symposium, etc. Country：Japan

Research Projects

閉経後高齢女性が発症リスクの拡張性心不全に対する分子機序解明及び治療法開発

Grant number：23K27509 2023.4 - 2028.3

日本学術振興会科学研究費助成事業基盤研究(B)

池田義之, 徳重明央, 窪薗琢郎, 赤崎雄一, 大石充

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Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）
抗がん剤による心筋および骨格筋障害に対するミトコンドリアを介した新規治療法の開発.

2020.4 - 2024.3

科学研究費補助金基盤研究(C)

赤﨑雄一、池田義之、窪薗琢郎、徳重明央、大石　充

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Authorship：Principal investigator
抗がん剤による心筋および骨格筋障害に対するミトコンドリアを介した新規治療法の開発

Grant number：20K07851 2020.4 - 2024.3

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C)

赤崎雄一, 池田義之, 窪薗琢郎, 大石充, 徳重明央

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Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

オルタナティブオートファジーの低下がドキソルビシンによる心筋障害および骨格筋障害の分子機序に関与することを明らかにし、治療方法確立を目指すことを目的として研究計画を立てた。A.基礎実験：(I) in vitro：H9c2ラット心筋芽細胞およびマウス骨格筋由来筋芽細胞株 C2C12 細胞を用いて以下の実験を行った。
（I）H9c2細胞およびC2C12細胞に、ドキソルビシンを投与し、H9c2細胞およびC2C12細胞の分化・増殖を評価した。C2C12細胞の分化・増殖については、抑制されていることが観察された。H9c2細胞についても分化・増殖については、抑制されていることが観察された。ミトコンドリアをMito-tracker Red Stainingにおいて観察した。C2C12細胞においては、分裂したミトコンドリアの増加を認めており、fissionに傾いていることが確認された。H9c2細胞においても同様に、分裂したミトコンドリアの増加を認めており、fissionに傾いていることが確認された。(II) in vivo：正常マウスC57BL6（WT）を用いて、ドキソルビシン心筋障害モデルを作成した。(II)-1.生理学的変化の検討；WTマウス(12週齢)に対して、ドキソルビシン投与を行う。投与4週間後において非投与群と心機能を比較検討した。ドキソルビシン投与群においては、左室拡大を認め、左室駆出力の低下を認めた。電子顕微鏡では、心筋において、分裂したミトコンドリア像の増加を認めており、fissionが増加していると考えられた。
オルタナティブオートファジーとマクロファージを標的としたサルコペニア治療法の確立.

2019.4 - 2023.3

科学研究費補助金基盤研究(C)

池田義之、窪薗琢郎、赤﨑雄一、大石　充

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Authorship：Coinvestigator(s)
オルタナティブオートファジーとマクロファージを標的としたサルコペニア治療法の確立

Grant number：19K07891 2019.4 - 2023.3

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C)

池田義之, 窪薗琢郎, 赤崎雄一, 大石充

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Grant amount：\3510000 （ Direct Cost: \2700000 、 Indirect Cost：\810000 ）

脂質異常症モデルマウスのApoEノックアウト（KO）マウスと野生型（C57BL6）マウスとで以下を検討した。１）筋力の計測：野生型と比較しApoE KOでは筋力が低値であった。その傾向は加齢とともにより顕著であった。２）筋肉量の計測：下肢筋の重量も上記筋肉量と同様に、野生型と比較しApoE KOで低値であった。その傾向は加齢とともにより顕著であった。３）免疫組織化学染色を行ったところ、ApoE KOマウスではFRβ陽性マクロファージが認められた。４）ApoE KOマウスでは筋肉にAGEが蓄積していた。５）ミトコンドリア機能を比較したところ、野生型と比較しApoE KOでミトコンドリア機能（ATP産生能）は低値であり、酸化ストレス（H2O2産生）は高値であった。以上より、脂質異常ではより筋肉の障害を来し、その要因として、ミトコンドリア機能障害やFRβ陽性マクロファージの関与が示唆された。今後はこれらミトコンドリア機能障害とFRβ陽性マクロファージがどのように関連しているかについて検討を進めていく。
培養筋肉細胞を用いた検討では、酸化LDLを添加した筋肉細胞ではコントロール刺激のみの筋肉細胞と比較し、ミトコンドリア機能障害（膜電位をJC-1やTMREにて測定）や酸化ストレス（mito-Sox Redにて評価）がより強かった。今後はマクロファージと筋肉細胞を共培養してさらなる研究を進める計画である。
ヒトを対象にした研究では、元々当該講座が実施している地域在住高齢者を対象としたコホート研究において、筋肉量や筋力測定を行い、また採血にて検体採取を行い可溶性FRβの測定を行う研究を計画しているが、このヒト対象研究に関しては後述の通りの事情により現在研究が計画通りに進展していない。今後状況が改善次第、再開していく計画である。
Exploratory study of novel diagnostic and therapeutic methods targeting macrophages for aortic aneurysms

Grant number：17K09593 2017.4 - 2021.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Miyata Masaaki

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

The role of macrophages in the pathogenesis of aortic aneurysms was investigated. In a mouse model of aortic aneurysm, we found that deletion of all macrophages suppressed the onset and progression of aortic aneurysm and promoted aortic aneurysm regression. Furthermore, in a mouse model of aneurysm, deletion of only activated macrophages suppressed the onset of aortic aneurysm and promoted regression of aortic aneurysm. In addition, immunohistochemistry using folate receptor β (FRβ) monoclonal antibody confirmed the presence of activated macrophages expressing FRβ in the removed aorta of patients undergoing aortic aneurysm surgery. A Kagoshima aortic aneurysm patient registry was established and blood soluble FRβ levels were measured in these patients.
ミトコンドリアダイナミクスとオートファージを標的としたサルコペニアの新規治療法.

2017.4 - 2020.3

科学研究費補助金基盤研究(C)

赤﨑雄一、池田義之、大石　充

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Authorship：Principal investigator
大動脈瘤に対するマクロファージを標的とした新規診断法と治療法の探索的研究.

2017.4 - 2020.3

科学研究費補助金基盤研究(C)

宮田昌明、池田義之、赤﨑雄一、大石　充、

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Authorship：Coinvestigator(s)
血管老化・動脈硬化に対するオルタナティブオートファジーを軸とした治療法の開発.

2016.4 - 2019.3

科学研究費補助金基盤研究(C)

池田義之、赤﨑雄一、大石　充

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Authorship：Coinvestigator(s)
大規模検診から高浸透率家系を抽出する新しい高血圧遺伝子同定法の確立.

2016.4 - 2019.3

科学研究費補助金基盤研究(C)

大石　充、池田義之、赤﨑雄一、吉満　誠

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Authorship：Coinvestigator(s)
サルコペニアにおけるレニン・アンジオテンシン系の作用およびメカニズムの解明.

2014.4 - 2017.3

科学研究費補助金基盤研究(C)

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Authorship：Principal investigator
サルコペニアに対するＡｋｔシグナルを標的とした新しい治療法の開発.

2012.8 - 2014.3

科学研究費補助金研究活動スタート支援

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Authorship：Principal investigator

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Social Activities

“世界高血圧の日”市民公開講座 in 鹿児島

Role(s)： Lecturer

鹿児島市 2019.5

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Audience： General

Type：Lecture

血圧を家でも測って健康に！！