日本分子生物学会

日本獣医学会

日本癌学会

Kayesh MEH, Kohara M, Tsukiyama-Kohara K .  Effects of neddylation on viral infection: an overview. .  Archives of virology169 ( 1 ) 6   2023.12Effects of neddylation on viral infection: an overview.Reviewed International journal

Akter L, Hashem MA, Rakib TM, Rashid MHO, Hossain KA, Akhter R, Utsunomiya M, Kitab B, Hifumi T, Miyoshi N, Maetani F, Tsukiyama-Kohara K .  Investigation of koala retrovirus in captive koalas with pneumonia and comparative analysis of subtype distribution. .  Archives of virology168 ( 12 ) 298   2023.11Investigation of koala retrovirus in captive koalas with pneumonia and comparative analysis of subtype distribution.Reviewed International journal

Ushirozako G, Murayama N, Tsukiyama-Kohara K, Yamazaki H, Uno Y .  Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p-nitrophenol. .  Xenobiotica; the fate of foreign compounds in biological systems   1 - 11   2023.11Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p-nitrophenol.Reviewed International journal

Hossain KA, Akhter R, Rashid MHO, Akter L, Utsunomiya M, Kitab B, Mm N, Hishiki T, Kohara M, Morita K, Tsukiyama-Kohara K .  Suppression of dengue virus replication by the French maritime pine extract Pycnogenol®. .  Virus research   199244   2023.10Suppression of dengue virus replication by the French maritime pine extract Pycnogenol®.Reviewed International journal

Okamoto R, Ito N, Ide Y, Kitab B, Sakoda Y, Tsukiyama-Kohara K .  Development of short hairpin RNA expression vectors targeting the internal ribosomal entry site of the classical swine fever virus genomic RNA. .  BMC biotechnology23 ( 1 ) 37   2023.9Development of short hairpin RNA expression vectors targeting the internal ribosomal entry site of the classical swine fever virus genomic RNA.Reviewed International journal

Kenzaburo Yamaji, Sadahiro Iwabuchi, Yuko Tokunaga, Shinichi Hashimoto, Daisuke Yamane, Sakiko Toyama, Risa Kono, Bouchra Kitab, Kyoko Tsukiyama-Kohara*, Yosuke Osawa, Yukiko Hayashi, Tsunekazu Hishima, Chise Tateno, Kiminori Kimura, Takeshi Okanoue, Michinori Kohara .  Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder .  Biomedicine & Pharmacotherapy166   115379   2023.8Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorderReviewed International coauthorship

Ushirozako G, Noda Y, Murayama N, Kawaguchi H, Tsukiyama-Kohara K, Yamazaki H, Uno Y .  Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A19. .  Drug metabolism and disposition: the biological fate of chemicals   2023.5Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A19.Reviewed International journal

Uno Y, Jikuya S, Noda Y, Oguchi A, Murayama N, Kawaguchi H, Tsukiyama-Kohara K, Yamazaki H .  Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes. .  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP   109579   2023.5Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes.Reviewed International journal

Yoshida O, Akbar SMF, Imai Y, Sanada T, Tsukiyama-Kohara K, Miyazaki T, Kamishita T, Miyake T, Tokumoto Y, Hikita H, Tsuge M, Shimizu M, Al Mahtab M, Aguilar JC, Guillen G, Kohara M, Hiasa Y .  Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18 months follow-up results of phase IIa clinical study. .  Hepatology research : the official journal of the Japan Society of Hepatology   2023.3Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18 months follow-up results of phase IIa clinical study.Reviewed International journal

Uno Y, Noda Y, Murayama N, Tsukiyama-Kohara K, Yamazaki H .  Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes. .  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP265   109534   2023.3Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes.Reviewed International journal

Kitab B, Tsukiyama-Kohara K .  Regulatory Role of Ribonucleotide Reductase Subunit M2 in Hepatocyte Growth and Pathogenesis of Hepatitis C Virus. .  International journal of molecular sciences24 ( 3 )   2023.1Regulatory Role of Ribonucleotide Reductase Subunit M2 in Hepatocyte Growth and Pathogenesis of Hepatitis C Virus.Reviewed International journal

Kayesh MEH, Khalil I, Kohara M, Tsukiyama-Kohara K .  Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview. .  Tropical medicine and infectious disease8 ( 1 )   2023.1Increasing Dengue Burden and Severe Dengue Risk in Bangladesh: An Overview.Reviewed International journal

Kayesh MEH, Kohara M, Tsukiyama-Kohara K .  TLR agonists as vaccine adjuvants in the prevention of viral infections: an overview. .  Frontiers in microbiology14   1249718   2023TLR agonists as vaccine adjuvants in the prevention of viral infections: an overview.Reviewed International journal

Kayesh MEH, Kohara M, Tsukiyama-Kohara K .  Epidemiology and Risk Factors for Acute Viral Hepatitis in Bangladesh: An Overview. .  Microorganisms10 ( 11 )   2022.11Epidemiology and Risk Factors for Acute Viral Hepatitis in Bangladesh: An Overview.Reviewed International journal

Uno Y, Ushirozako G, Uehara S, Murayama N, Fujiki Y, Kawaguchi H, Tsukiyama-Kohara K, Yamazaki H .  Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes. .  Xenobiotica; the fate of foreign compounds in biological systems   1 - 10   2022.11Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes.Reviewed International journal

Kayesh MEH, Hashem MA, Maetani F, Goto A, Nagata N, Kasori A, Imanishi T, Tsukiyama-Kohara K .  Molecular Insights into Innate Immune Response in Captive Koala Peripheral Blood Mononuclear Cells Co-Infected with Multiple Koala Retrovirus Subtypes. .  Pathogens (Basel, Switzerland)11 ( 8 )   2022.8Molecular Insights into Innate Immune Response in Captive Koala Peripheral Blood Mononuclear Cells Co-Infected with Multiple Koala Retrovirus Subtypes.Reviewed International journal

Characterization of host factors associated with the internal ribosomal entry sites of foot-and-mouth disease and classical swine fever viruses. .    12 ( 1 ) 6709   2022.4Characterization of host factors associated with the internal ribosomal entry sites of foot-and-mouth disease and classical swine fever viruses.Reviewed International coauthorship

Kayesh MEH, Kohara M, Tsukiyama-Kohara K .  An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants. .  Viruses13 ( 11 )   2021.11An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants.Reviewed International journal

Kayesh MEH, Sanada T, Kohara M, Tsukiyama-Kohara K .  Tree Shrew as an Emerging Small Animal Model for Human Viral Infection: A Recent Overview. .  Viruses13 ( 8 )   2021.8Tree Shrew as an Emerging Small Animal Model for Human Viral Infection: A Recent Overview.Reviewed International journal

Hashem MA, Kayesh MEH, Maetani F, Eiei T, Mochizuki K, Ochiai S, Ito A, Ito N, Sakurai H, Asai T, Tsukiyama-Kohara K .  Koala retrovirus (KoRV) subtypes and their impact on captive koala (Phascolarctos cinereus) health. .  Archives of virology166 ( 7 ) 1893 - 1901   2021.7Koala retrovirus (KoRV) subtypes and their impact on captive koala (Phascolarctos cinereus) health.Reviewed International journal

Makoto Saito1,*, Yasushi Itoh2,*, Fumihiko Yasui1,*, Tsubasa Munakata1, Daisuke Yamane1, Makoto Ozawa3, Risa Ito4, Takayuki Katoh4, Hirohito Ishigaki2, Misako Nakayama2, Shintaro Shichinohe2, Kenzaburo Yamaji1, Naoki Yamamoto1, Ai Ikejiri1, Tomoko Honda1, Takahiro Sanada1, Yoshihiro Sakoda5, Hiroshi Kida6, Le Thi Quynh Mai7, Yoshihiro Kawaoka8, Kazumasa Ogasawara2, Kyoko Tsukiyama-Kohara3,†, Hiroaki Suga4,†, and Michinori Kohara .  Targeted macrocycles hamper hemagglutinin adsorption and fusion, and have antiviral effects in murine and macaque models of influenza .  Nature Communications12 ( 1 ) 2654   2021.5Targeted macrocycles hamper hemagglutinin adsorption and fusion, and have antiviral effects in murine and macaque models of influenzaReviewed International coauthorship

Abounouh K. .  Blocking neddylation elicits antiviral effect against hepatitis B virus replication .  Molecular Biology Reports   2021Reviewed International journal

Kayesh M.E.H. .  Mammalian animal models for dengue virus infection: a recent overview .  Archives of Virology167 ( 1 ) 31 - 44   2021Reviewed International journal

Takagi A, Amako Y, Yamane D, Kitab B, Tokunaga Y, El-Gohary A, Kohara M, Tsukiyama-Kohara K .  Longer Poly(U) Stretches in the 3'UTR Are Essential for Replication of the Hepatitis C Virus Genotype 4a Clone in <i>in vitro</i> and <i>in vivo</i>. .  Frontiers in microbiology12   764816   2021Longer Poly(U) Stretches in the 3'UTR Are Essential for Replication of the Hepatitis C Virus Genotype 4a Clone in <i>in vitro</i> and <i>in vivo</i>.Reviewed International journal

Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara .  Toll-like Receptor Response to Human Immunodeficiency Virus Type 1 or Co-Infection with Hepatitis B or C Virus: An Overview. .  International journal of molecular sciences24 ( 11 )   2023.6Toll-like Receptor Response to Human Immunodeficiency Virus Type 1 or Co-Infection with Hepatitis B or C Virus: An Overview.Reviewed International journal

Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Takahiro Sanada, Bouchra Kitab, Md Haroon Or Rashid, Lipi Akter, Sayeh Ezzikouri, Shuko Murakami, Shintaro Ogawa, Yasuhito Tanaka, Michinori Kohara and Kyoko Tsukiyama-Kohara .  Characterization of innate immune response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model .  Frontiers in Virology2   926831   2022.8Reviewed International coauthorship International journal

Md Abul Hashem, Mohammad Enamul Hoque Kayesh, Fumie Maetani, Atsushi Goto, Noriko Nagata, Aki Kasori, Tetsuya Imanishi, Kyoko Tsukiyama-Kohara .  Subtype distribution and expression of the koala retrovirus in the Japanese zoo koala population. .  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases102   105297 - 105297   2022.8Reviewed International journal

Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants. .      2022.5Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants.Reviewed International coauthorship

Kayesh MEH, Kohara M, Tsukiyama-Kohara K. .  Toll-like Receptor Response to Hepatitis C Virus Infection: A Recent Overview. .  Int J Mol Sci.23 ( 10 ) 5475   2022.5Toll-like Receptor Response to Hepatitis C Virus Infection: A Recent Overview.Reviewed International coauthorship

Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara .  Toll-like Receptor Response to Hepatitis C Virus Infection: A Recent Overview. .  International journal of molecular sciences23 ( 10 )   2022.5Reviewed International journal

Wahiba Ezzemani, Anass Kettani, Subrahmanyam Sappati, Kavya Kondaka, Hicham El Ossmani, Kyoko Tsukiyama-Kohara, Haya Altawalah, Rachid Saile, Michinori Kohara, Soumaya Benjelloun, Sayeh Ezzikouri .  Reverse vaccinology-based prediction of a multi-epitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants. .  Journal of biomolecular structure & dynamics   1 - 22   2022.5Reviewed International journal

Hashem MA, Kayesh MEH, Maetani F, Goto A, Nagata N, Kasori A, Imanishi T, Tsukiyama-Kohara K .  Subtype distribution and expression of the koala retrovirus in the Japanese zoo koala population. .  Infect Genet Evol.   105297   2022.5Subtype distribution and expression of the koala retrovirus in the Japanese zoo koala population.Reviewed International coauthorship

Yutaro Ide, Bouchra Kitab, Nobumasa Ito, Riai Okamoto, Yui Tamura, Takafumi Matsui, Yoshihiro Sakoda, Kyoko Tsukiyama-Kohara .  Characterization of host factors associated with the internal ribosomal entry sites of foot-and-mouth disease and classical swine fever viruses. .  Scientific reports12 ( 1 ) 6709 - 6709   2022.4Reviewed International journal

Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Michinori Kohara, Kyoko Tsukiyama-Kohara .  In vivo Delivery Tools for Clustered Regularly Interspaced Short Palindromic Repeat/Associated Protein 9-Mediated Inhibition of Hepatitis B Virus Infection: An Update. .  Frontiers in microbiology13   953218 - 953218   2022Reviewed International journal

Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara .  Toll-Like Receptor Response to Hepatitis B Virus Infection and Potential of TLR Agonists as Immunomodulators for Treating Chronic Hepatitis B: An Overview. .  International journal of molecular sciences22 ( 19 )   2021.9Reviewed International journal

Islam Abbadi, Mustapha Lkhider, Bouchra Kitab, Khalid Jabboua, Imane Zaidane, Asmaa Haddaji, Sabrine Nacer, Aya Matsuu, Pascal Pineau, Kyoko Tsukiyama-Kohara, Soumaya Benjelloun, Sayeh Ezzikouri .  Non-primate hepacivirus transmission and prevalence: Novel findings of virus circulation in horses and dogs in Morocco. .  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases93   104975 - 104975   2021.9Reviewed International journal

ケアシュ・モハメド, 尼子 豊, ハシェム・モハメド, 山本 直樹, 杉山 真也, 溝上 雅史, 小原 道法, 小原 恭子 .  B型肝炎ウイルスcccDNAを標的としたCRISPR/Cas9システムの生体内送達法の開発 .  日本癌学会総会記事80回   [J3 - 5]   2021.9B型肝炎ウイルスcccDNAを標的としたCRISPR/Cas9システムの生体内送達法の開発Reviewed International journal

Honda T, Gomi S, Yamane D, Yasui F, Yamamoto T, Munakata T, Itoh Y, Ogasawara K, Sanada T, Yamaji K, Yasutomi Y, Tsukiyama-Kohara K, Kohara M. .  Development and Characterization of a Highly Sensitive NanoLuciferase-Based Immunoprecipitation System for the Detection of Anti-Influenza Virus HA .  mSphere6 ( 3 ) e1342-20   2021.5Development and Characterization of a Highly Sensitive NanoLuciferase-Based Immunoprecipitation System for the Detection of Anti-Influenza Virus HA Reviewed

Tomoko Honda, Sumiko Gomi, Daisuke Yamane, Fumihiko Yasui, Takuya Yamamoto, Tsubasa Munakata, Yasushi Itoh, Kazumasa Ogasawara, Takahiro Sanada, Kenzaburo Yamaji, Yasuhiro Yasutomi, Kyoko Tsukiyama-Kohara, Michinori Kohara .  Development and Characterization of a Highly Sensitive NanoLuciferase-Based Immunoprecipitation System for the Detection of Anti-Influenza Virus HA Antibodies. .  mSphere6 ( 3 ) 1 - 14   2021.5Reviewed International journal

Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh, Hirohito Ishigaki, Misako Nakayama, Shintaro Shichinohe, Kenzaburo Yamaji, Naoki Yamamoto, Ai Ikejiri, Tomoko Honda, Takahiro Sanada, Yoshihiro Sakoda, Hiroshi Kida, Thi Quynh Mai Le, Yoshihiro Kawaoka, Kazumasa Ogasawara, Kyoko Tsukiyama-Kohara, Hiroaki Suga, Michinori Kohara .  Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models. .  Nature communications12 ( 1 ) 2654 - 2654   2021.5Reviewed International journal

Toll-Like Receptor and Cytokine Responses to Infection with Endogenous and Exogenous Koala Retrovirus, and Vaccination as a Control Strategy .  Curr Issues Mol Biol. 43 ( 1 ) 52 - 64   2021.4Toll-Like Receptor and Cytokine Responses to Infection with Endogenous and Exogenous Koala Retrovirus, and Vaccination as a Control StrategyReviewed International coauthorship

Md Abul Hashem1, 2, 3, Mohammad Enamul Hoque Kayesh1, 2, 4, Fumie Maetani5, Taiki Eiei5, Kyoya Mochizuki5, Shinsaku Ochiai5, Ayaka Ito5, Nanao Ito5, Hiroko Sakurai5, Takayuki Asai5 and Kyoko Tsukiyama-Kohara .  Koala retrovirus (KoRV) subtypes and their impact on captive koala (Phascolarctos cinereus) health .  Archives of Virologyaccepted   2021.4Koala retrovirus (KoRV) subtypes and their impact on captive koala (Phascolarctos cinereus) healthReviewed

Mohammad Enamul Hoque Kayesh 1,2 , Md Abul Hashem 1,3,4 and Kyoko Tsukiyama-Kohara .  Toll-Like Receptor Expression Profiles in Koala (Phascolarctos cinereus) Peripheral Blood Mononuclear Cells Infected with Multiple KoRV Subtypes .    11   983   2021.4Toll-Like Receptor Expression Profiles in Koala (Phascolarctos cinereus) Peripheral Blood Mononuclear Cells Infected with Multiple KoRV SubtypesReviewed

Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Kyoko Tsukiyama-Kohara .  Toll-Like Receptor Expression Profiles in Koala (Phascolarctos cinereus) Peripheral Blood Mononuclear Cells Infected with Multiple KoRV Subtypes. .  Animals : an open access journal from MDPI11 ( 4 )   2021.4Reviewed International journal

Nagai M, Okabayashi T, Akagami M, Matsuu A, Fujimoto Y, Hashem MA, Mekata H, Nakao R, Matsuno K, Katayama Y, Oba M, Omatsu T, Asai T, Nakagawa K, Ito H, Madarame H, Kawai K, Ito T, Nonaka N, Tsukiyama-Kohara K, Inoshima Y, Mizutani T, Misawa N. .  Metagenomic identification, sequencing, and genome analysis of porcine hepe-astroviruses (bastroviruses) in porcine feces in Japan .  Infect Genet Evol.88   104664   2021.3Metagenomic identification, sequencing, and genome analysis of porcine hepe-astroviruses (bastroviruses) in porcine feces in JapanReviewed

Makoto Nagai, Tamaki Okabayashi, Masataka Akagami, Aya Matsuu, Yoshikazu Fujimoto, Md Abul Hashem, Hirohisa Mekata, Ryo Nakao, Keita Matsuno, Yukie Katayama, Mami Oba, Tsutomu Omatsu, Tetsuo Asai, Keisuke Nakagawa, Hiroshi Ito, Hiroo Madarame, Kazuhiro Kawai, Toshihiro Ito, Nariaki Nonaka, Kyoko Tsukiyama-Kohara, Yasuo Inoshima, Tetsuya Mizutani, Naoaki Misawa .  Metagenomic identification, sequencing, and genome analysis of porcine hepe-astroviruses (bastroviruses) in porcine feces in Japan. .  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases88   104664 - 104664   2021.3Reviewed International journal

Suzuki Y, Onuma H, Sato R, Sato Y, Hashiba A, Maeki M, Tokeshi M, Kayesh MEH, Kohara M, Tsukiyama-Kohara K, Harashima H. .  Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition. .    330   67 - 71   2021.2Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition.Reviewed

Yuichi Suzuki, Haruno Onuma, Risa Sato, Yusuke Sato, Akari Hashiba, Masatoshi Maeki, Manabu Tokeshi, Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara, Hideyoshi Harashima .  Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition. .  Journal of controlled release : official journal of the Controlled Release Society330   61 - 71   2021.2Reviewed International journal

Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara .  Recent Insights Into the Molecular Mechanism of Toll-Like Receptor Response to Dengue Virus Infection. .  Frontiers in microbiology12   744233 - 744233   2021Reviewed International journal

CD4, CD8b, and Cytokines Expression Profiles in Peripheral Blood Mononuclear Cells Infected with Different Subtypes of KoRV from Koalas (Phascolarctos cinereus) in a Japanese Zoo. .  Viruses12 ( 12 ) 1415   2020.12CD4, CD8b, and Cytokines Expression Profiles in Peripheral Blood Mononuclear Cells Infected with Different Subtypes of KoRV from Koalas (Phascolarctos cinereus) in a Japanese Zoo.

Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Fumie Maetani, Taiki Eiei, Kyoya Mochizuki, Shinsaku Ochiai, Ayaka Ito, Nanao Ito, Hiroko Sakurai, Takayuki Asai, Kyoko Tsukiyama-Kohara .  CD4, CD8b, and Cytokines Expression Profiles in Peripheral Blood Mononuclear Cells Infected with Different Subtypes of KoRV from Koalas (Phascolarctos cinereus) in a Japanese Zoo. .  Viruses12 ( 12 )   2020.12Reviewed International journal

Ezzikouri S, Nourlil J, Benjelloun S, Kohara M, Tsukiyama-Kohara K. .  Coronavirus disease 2019-Historical context, virology, pathogenesis, immunotherapy, and vaccine development. .  Hum Vaccin Immunother. 16 ( 12 ) 2992 - 3000   2020.12Coronavirus disease 2019-Historical context, virology, pathogenesis, immunotherapy, and vaccine development.Invited Reviewed

Kayesh MEH, Amako Y, Hashem MA, Murakami S, Ogawa S, Yamamoto N, Hifumi T, Miyoshi N, Sugiyama M, Tanaka Y, Mizokami M, Kohara M, Tsukiyama-Kohara K. .  Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA .  Virus Research290   198191   2020.12Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNAReviewed

Sayeh Ezzikouri, Jalal Nourlil, Soumaya Benjelloun, Michinori Kohara, Kyoko Tsukiyama-Kohara .  Coronavirus disease 2019-Historical context, virology, pathogenesis, immunotherapy, and vaccine development. .  Human vaccines & immunotherapeutics16 ( 12 ) 2992 - 3000   2020.12Reviewed International journal

Elmessaoudi-Idrissi M, Tsukiyama-Kohara K, Nourlil J, Kettani A, Windisch MP, Kohara M, Malik YS, Dhama K, Benjelloun S, Ezzikouri S. .  Structure-guided discovery approach identifies potential lead compounds targeting M pro of SARS-CoV-2 .  Virusdisease   2020.11Structure-guided discovery approach identifies potential lead compounds targeting M pro of SARS-CoV-2Reviewed

Sayeh Ezzikouri, Jalal Nourlil, Kyoko Tsukiyama-Kohara, Michinori Kohara, Hicham El Ossmani, Marc P Windisch, Soumaya Benjelloun .  Nanobodies: an unexplored opportunity to combat COVID-19. .  Journal of biomolecular structure & dynamics   1 - 3   2020.11Reviewed International journal

Kayesh MEH, Hashem MA, Tsukiyama-Kohara K. .  Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review. .  Arch Virol. 165 ( 11 ) 2409 - 2417   2020.11Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review.Invited Reviewed

Ezzikouri S, Nourlil J, Tsukiyama-Kohara K, Kohara M, El Ossmani H, Windisch MP, Benjelloun S. .  Nanobodies: an unexplored opportunity to combat COVID-19 .  J Biomol Struct Dyn.10   1 - 3   2020.11Nanobodies: an unexplored opportunity to combat COVID-19Reviewed

Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Kyoko Tsukiyama-Kohara .  Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review. .  Archives of virology165 ( 11 ) 2409 - 2417   2020.11Reviewed International journal

Hashem MA, Maetani F, Kayesh MEH, Eiei T, Mochizuki K, Ito A, Sakurai H, Asai T, Tsukiyama-Kohara K. .  Transmission of koala retrovirus from parent koalas to a joey in a Japanese zoo. .  Journal of Virolgy94 ( 11 ) e0019-20   2020.5Transmission of koala retrovirus from parent koalas to a joey in a Japanese zoo.Reviewed

Chi Hai-Ying, Yuuki Tanaka, Tatsuro Hifumi, Ko-ichiro Shoji, Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Bouchra Kitab, Takahiro Sanada, Tomoko Fujiyuki, Misako Yoneda, Hitoshi Hatai, Akira Yabuki, Noriaki Miyoshi, Chieko Kai, Michinori Kohara, Kyoko Tsukiyama-Kohara .  Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (Tree shrew) .  PLoS One15 ( 5 ) e0233232   2020.5Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (Tree shrew)Reviewed

Sayeh Ezzikouri, Mohammad Enamul Hoque Kayesh, Soumaya Benjelloun, Michinori Kohara and Kyoko Tsukiyama-Kohara .  Targeting host innate and adaptive immunity to achieve the functional cure of chronic hepatitis B .  Vaccines8 ( 2 ) E216   2020.5Targeting host innate and adaptive immunity to achieve the functional cure of chronic hepatitis B Reviewed

Mohammad Enamul Hoque Kayesh 1,2 , Md Abul Hashem 1, Bouchra Kitab 1 and Kyoko Tsukiyama-Kohara .  Pathogenesis and Immune Response Caused by Vector-Borne and Other Viral Infections in a Tupaia Model .  microorganism   2019.12Pathogenesis and Immune Response Caused by Vector-Borne and Other Viral Infections in a Tupaia ModelInvited Reviewed

Sanada T, Yamamoto N, Kayesh MEH, Tsukiyama-Kohara K, Hasegawa H, Miyazaki T, Takano JI, Shiogama Y, Yasutomi Y, Goh Y, Yoshida O, Hiasa Y, Kohara M. .  Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response. .  Biochem Biophys Res Commun.520 ( 1 ) 86 - 92   2019.11Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response.Reviewed

Takahiro Sanada, Naoki Yamamoto, Mohammad Enamul Hoque Kayesh, Kyoko Tsukiyama-Kohara, Hideki Hasegawa, Takashi Miyazaki, Jun-Ichiro Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Yasumasa Goh, Osamu Yoshida, Yoichi Hiasa, Michinori Kohara .  Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response. .  Biochemical and biophysical research communications520 ( 1 ) 86 - 92   2019.11Reviewed International journal

Hashem MA, Kayesh MEH, Yamato O, Maetani F, Eiei T, Mochizuki K, Sakurai H, Ito A, Kannno H, Kasahara T, Amano Y, Tsukiyama-Kohara K. .  Coinfection with koala retrovirus subtypes A and B and its impact on captive koalas in Japanese zoos. .  Arch Virol. 164 ( 11 ) 2735 - 2745   2019.11Coinfection with koala retrovirus subtypes A and B and its impact on captive koalas in Japanese zoos.Reviewed

Md Abul Hashem, Mohammad Enamul Hoque Kayesh, Osamu Yamato, Fumie Maetani, Taiki Eiei, Kyoya Mochizuki, Hiroko Sakurai, Ayaka Ito, Hiroki Kannno, Tatsuya Kasahara, Yusuke Amano, Kyoko Tsukiyama-Kohara .  Coinfection with koala retrovirus subtypes A and B and its impact on captive koalas in Japanese zoos. .  Archives of virology164 ( 11 ) 2735 - 2745   2019.11Reviewed International journal

Sanada T, Tsukiyama-Kohara K, Shin-I T, Yamamoto N, Kayesh MEH, Yamane D, Takano JI, Shiogama Y, Yasutomi Y, Ikeo K, Gojobori T, Mizokami M, Kohara M. .  Construction of complete Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing. .  Sci Rep. 9 ( 1 ) 12372   2019.8Construction of complete Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing. Reviewed

Takahiro Sanada, Kyoko Tsukiyama-Kohara, Tadasu Shin-I, Naoki Yamamoto, Mohammad Enamul Hoque Kayesh, Daisuke Yamane, Jun-Ichiro Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Kazuho Ikeo, Takashi Gojobori, Masashi Mizokami, Michinori Kohara .  Construction of complete Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing. .  Scientific reports9 ( 1 ) 12372 - 12372   2019.8Reviewed International journal

Matsui T, Handa Y, Kanda T, Tsukiyama-Kohara K. .  Silencing of the foot-and-mouth disease virus internal ribosomal entry site by targeting relatively conserved region among serotypes. .  Virus Genes.   2019.7Silencing of the foot-and-mouth disease virus internal ribosomal entry site by targeting relatively conserved region among serotypes. Reviewed

Kitab B, Satoh M, Ohmori Y, Munakata T, Sudoh M, Kohara M, Tsukiyama-Kohara K .  Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation. .  J. Biol. Chem.294 ( 15 ) 5759 - 5773   2019.4Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation.Reviewed

Sanada T, Yasui F, Honda T, Kayesh MEH, Takano JI, Shiogama Y, Yasutomi Y, Tsukiyama-Kohara K, Kohara M. .  Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri). .  Virology529   101 - 110   2019.3Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri).Reviewed

Kayesh MEH, Yamato O, Rahman MM, Hashem MA, Maetani F, Eiei T, Mochizuki K, Sakurai H, Tsukiyama-Kohara K. .  Molecular dynamics of koala retrovirus infection in captive koalas in Japan. .  Arch. Virol.164 ( 3 ) 757 - 765   2019.3Molecular dynamics of koala retrovirus infection in captive koalas in Japan.Reviewed

Takahiro Sanada, Fumihiko Yasui, Tomoko Honda, Mohammad Enamul Hoque Kayesh, Jun-Ichiro Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Kyoko Tsukiyama-Kohara, Michinori Kohara .  Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri). .  Virology529   101 - 110   2019.3Reviewed International journal

Kitab, B., Kohara, M., Tsukiyama-Kohara, K. .  Experimental in vitro and in vivo systems for studying the innate immune response during dengue virus infections. .  Arch Virol.163 ( 7 ) 1717 - 1726   2018.7Experimental in vitro and in vivo systems for studying the innate immune response during dengue virus infections.Reviewed

Kyoko Tsukiyama-Kohara, Michinori Kohara .  Hepatitis C Virus: Viral Quasispecies and Genotype .  International Journal of Molecular Sciences19 ( 23 ) 1 - 8   2017.12Hepatitis C Virus: Viral Quasispecies and GenotypeInvited Reviewed

Kyoko Tsukiyama-Kohara, Michinori Kohara .  Hepatitis C Virus: Viral Quasispecies and Genotypes. .  International journal of molecular sciences19 ( 1 )   2017.12Reviewed International journal

Nze-Nkogue C, Horie M, Fujita S, Inoue E, Akomo-Okoue EF, Ozawa M, Ngomanda A, Yamagiwa J, Tsukiyama-Kohara K. .  Identification and molecular characterization of novel primate bocaparvoviruses from wild western lowland gorillas of Moukalaba-Doudou National Park, Gabon. .  Infect Genet Evol.53   30 - 37   2017.9Identification and molecular characterization of novel primate bocaparvoviruses from wild western lowland gorillas of Moukalaba-Doudou National Park, Gabon.Reviewed

Chimene NZE NKOGUE .  Epidemiological study of viruses infecting western lowland gorillas in Moukalaba-Doudou National Park (Gabon) .      2017.9Epidemiological study of viruses infecting western lowland gorillas in Moukalaba-Doudou National Park (Gabon)Reviewed

Kayesh MEH, Ezzikouri S, Chi H, Sanada T, Hayashi, Y., Rebbani, K., Kitab, B., Matuu, A., Miyoshi, N., Hishima, T., Kohara, M., Tsukiyama-Kohara, K. .  Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri. .  Scientific Reports7 ( 1 ) 9848 - 9861   2017.8Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri. Reviewed

Kayesh ME*, Kitab B*, Sanada T, Hayasaka D, Morita K, Kohara M, Tsukiyama-Kohara K .  Susceptibility of tupaia cells to dengue virus infection and their initial immune response. .  Infection Genetics and Evolution51   203 - 210   2017.7Susceptibility of tupaia cells to dengue virus infection and their initial immune response.Reviewed

KAYESH MEH, EZZIKOURI S, CHI H, SANADA T, YAMAMOTO N, KITAB B, HARAGUCHI T, MATUYAMA R, NKOGUE CN, HATAI H, MIYOSHI N, MURAKAMI S, TANAKA Y, TAKANO J, SHIOGAMA Y, YASUTOMI Y, KOHARA M, TSUKIYAMA-KOHARA K. .  Interferon-β response is impaired by hepatitis B virus infection in Tupaia belangeri. .  VIRUS RESEARCH237   47 - 57   2017.6Interferon-β response is impaired by hepatitis B virus infection in Tupaia belangeri. Reviewed

Tokunaga Y, Osawa Y, Ohtsuki T, Hayashi Y, Yamaji K, Yamane D, Hara M, Munekata K, Tsukiyama-Kohara K, Hishima T, Kojima S, Kimura K, Kohara M. .  Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model. .  Sci Rep.7 ( 1 ) 325   2017.3Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model.Reviewed

Chime`ne Nze Nkogue, Masayuki Horie, Shiho Fujita, Michiko Ogino, Yuki Kobayashi, Keijiro Mizukami, Tatsunori Masatani, Sayeh Ezzikouri, Aya Matsuu, Tetsuya Mizutani, Makoto Ozawa, Osamu Yamato, Alfred Ngomanda, Juichi Yamagiwa, Kyoko Tsukiyama-Kohara .  Molecular epidemiological study of adenovirus infecting western lowland gorillas and humans in and around Moukalaba-Doudou National Park (Gabon) .  Virus Genes52 ( 5 ) 671 - 678   2016.10Molecular epidemiological study of adenovirus infecting western lowland gorillas and humans in and around Moukalaba-Doudou National Park (Gabon)Reviewed

Sayeh Ezzikouri, Fatima Zahra Jadid, Salsabil Hamdi, Kyoko Tsukiyama-Kohara, Soumaya Benjelloun .  Supplementation of Pycnogenol to conventional treatment may improve type 2 diabetes-associated with Hepatitis C Therapy .  Journal of Clinical and Translational Hepatology4 ( 3 ) 228 - 233   2016.9Supplementation of Pycnogenol to conventional treatment may improve type 2 diabetes-associated with Hepatitis C TherapyReviewed

Takahisa Kouwaki, Yoshimi Fukushima, Takuji Daito, Naoki Yamamoto, Edin J Mifsud, Chean Ring Leong, Kyoko Tsukiyama-Kohara, Michinori Kohara, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi .  Exosome RNA Released by Hepatocytes Regulates Innate Immune Responses to Hepatitis B Virus Infection .  Frontiers in Immunology7   335   2016.8Exosome RNA Released by Hepatocytes Regulates Innate Immune Responses to Hepatitis B Virus InfectionReviewed

Hai-Ying C, Nagano K, Ezzikouri S, Yamaguchi C, Kayesh ME, Rebbani K, Kitab B, Nakano H, Kouji H, Kohara M, Tsukiyama-Kohara K. .  Establishment of an intermittent cold stress model using Tupaia belangeri and evaluation of compound C737 targeting neuron-restrictive silencer factor. .  Exp. Anim.65 ( 3 ) 285 - 292   2016.7Establishment of an intermittent cold stress model using Tupaia belangeri and evaluation of compound C737 targeting neuron-restrictive silencer factor.Reviewed

Rebban, K & iTsukiyama-Kohara, K. .  HCV-Induced Oxidative Stress: Battlefield-Winning Strategy .  Oxidative Medicine and Cellular Longevity2016 ( 2016 ) 7425628   2016.5HCV-Induced Oxidative Stress: Battlefield-Winning StrategyInvited Reviewed

Kanda T, Ozawa M, Tsukiyama-Kohara K .  IRES-mediated translation of foot-andmouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals .  BMC Veterinary Research12   66   2016.3IRES-mediated translation of foot-andmouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animalsReviewed

Sanada, T., Tsukiyama-Kohara, K., Yamamoto, N., Ezzikouri, S., Benjelloun, S., Murakami, S., Tanaka, Y., Tateno, C., Kohara, M. .  Property of hepatitis B virus replication in tupaia belangeri hepatocytes .  BBRC8 ( 469 ) 229 - 235   2016.1Property of hepatitis B virus replication in tupaia belangeri hepatocytesReviewed

Khadija Rhebbani, Kyoko Tsukiyama-Kohara .  DHCR24:A Novel HCC Biomaker at a Glance .  Clinical Microbiology4 ( 6 ) 1000228   2015.12DHCR24:A Novel HCC Biomaker at a GlanceInvited Reviewed

Masatani T, Ozawa M, Yamada K, Ito N, Horie M, Matsuu A, Okuya K, Tsukiyama-Kohara K, Sugiyama M, Nishizono A. .  Contribution of the interaction between rabies virus P protein and IKKε to the inhibition of type I interferon induction signaling. .  J Gen. Virol.   2015.12Contribution of the interaction between rabies virus P protein and IKKε to the inhibition of type I interferon induction signaling.Reviewed

Ohtsuki T, Kimura K, Tokunaga Y, Tsukiyama-Kohara K, Tateno C, Hayashi Y, Hishima T, Kohara M. .  M2 macrophages play critical roles in progression of inflammatory liver disease in hepatitis C virus transgenic mice. .  J Virol.14 ( 90 ) 307 - 309   2015.10M2 macrophages play critical roles in progression of inflammatory liver disease in hepatitis C virus transgenic mice.Reviewed

Okuya K, Kawabata T, Nagano K, Tsukiyama-Kohara K, Kusumoto I, Takase K, Ozawa M. .  Isolation and characterization of influenza A viruses from environmental water at an overwintering site of migratory birds in Japan. .  Arch Virol.   2015.9Isolation and characterization of influenza A viruses from environmental water at an overwintering site of migratory birds in Japan.Reviewed

Full genome sequences of torque teno sus virus strains that coinfected a pig with postweaning multisystemic wasting syndrome in Japan: implications for genetic diversity. .      2015.9Full genome sequences of torque teno sus virus strains that coinfected a pig with postweaning multisystemic wasting syndrome in Japan: implications for genetic diversity.Reviewed

Miura R, Kooriyama T, Yoneda M, Takenaka A, Doki M, Goto Y, Sanjoba C, Endo Y, Fujiyuki T, Sugai A, Tsukiyama-Kohara K, Matsumoto Y, Sato H, Kai C. .  Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs. .  PLoS Negl Trop Dis.10 ( 9 ) e0003914   2015.7Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs.Reviewed

Matsuu A, Hobo S, Ando K, Sanekata T, Sato F, Endo Y, Amaya T, Osaki T, Horie M, Masatani T, Ozawa M, Tsukiyama-Kohara K .  Genetic and serological surveillance for non-primate hepacivirus inhorses in Japan .  Veterinary Microbiologyin press   2015.6Genetic and serological surveillance for non-primate hepacivirus inhorses in JapanReviewed

Sayeh Ezzikouri, Kiminori Kimura, Hajime Sunagozaka, Shuichi Kaneko, Kazuaki Inoue, Tomohiro Nishimura, Tsunekazu Hishima, Michinori Kohara, and Kyoko Tsukiyama-Kohara .  Serum DHCR24 auto-antibody as a new biomarker for progression of hepatitis C .  EBioMedicine2   604 - 612   2015.4Serum DHCR24 auto-antibody as a new biomarker for progression of hepatitis C Reviewed

Makoto Saito, Takashi Takano, Tomohiro Nishimura, Michinori Kohara, Kyoko Tsukiyama-Kohara .  3β-Hydroxysterol Δ24-reductase on the Surface of Hepatitis C Virus-related Hepatocellular Carcinoma Cells can be a Target for Molecular Targeting Therapy .  PLoS One   e0124197   2015.43β-Hydroxysterol Δ24-reductase on the Surface of Hepatitis C Virus-related Hepatocellular Carcinoma Cells can be a Target for Molecular Targeting TherapyReviewed

Ozawa M, Matsuu A, Yonezawa K, Igarashi M, Okuya K, Kawabata T, Ito K, Tsukiyama-Kohara K, Taneno A, Deguchi E. .  Efficient isolation of Swine influenza viruses by age-targeted specimen collection. .  J Clin Microbiol. 201553 ( 4 ) 1331 - 1338   2015.4Efficient isolation of Swine influenza viruses by age-targeted specimen collection.Reviewed

新井　正明 .  Establishment of evaluation systems of antiviral agents for hepatitis C virus and analysis of cyclophilin inhibitors as anti-HCV drugs .      2015.3Establishment of evaluation systems of antiviral agents for hepatitis C virus and analysis of cyclophilin inhibitors as anti-HCV drugsReviewed

Ezzikouri S, Nishimura T, Kohara M, Benjelloun S, Kino Y, Inoue K, Matsumori A, Tsukiyama-Kohara K .  Inhibitory Effects of PycnogenolR on Hepatitis C Virus Replication .  Antiviral Research113   93 - 102   2015.1Inhibitory Effects of PycnogenolR on Hepatitis C Virus ReplicationReviewed

Takenaka A, Yoneda M, Seki T, Uema M, Kooriyama T, Nishi T, Fujita K, Miura R, Tsukiyama-Kohara K, Sato H, Kai C. .  Characterization of two recent Japanese field isolates of canine distemper virus and examination of the avirulent strain utility as an attenuated vaccine. .  Vet Microbiol. 174 ( 42067 ) 372 - 381   2014.12Characterization of two recent Japanese field isolates of canine distemper virus and examination of the avirulent strain utility as an attenuated vaccine.Reviewed

Kyoko Tsukiyama-Kohara and Michinori Kohara .  Tupaia belangeri as an experimental animal model for viral infection .  Experimental Animal63 ( 4 ) 367 - 374   2014.10Tupaia belangeri as an experimental animal model for viral infectionReviewed

Mohammad Zare-Bidaki, Kyoko Tsukiyama-Kohara, Mohammad Kazemi Arababadi .  Toll like receptor 4 and hepatitis B infection; molecular mechanisms and pathogenesis .  Viral Immunology27 ( 7 ) 321 - 326   2014.9Toll like receptor 4 and hepatitis B infection; molecular mechanisms and pathogenesisReviewed

Ezzikouri S, Ozawa M, Kohara M, Elmdaghri N, Benjelloun S, Tsukiyama-Kohara K. .  Recent insights into hepatitis B virus-host interactions. .  J Med Virol.86 ( 6 ) 925 - 932   2014.6Recent insights into hepatitis B virus-host interactions.Reviewed

Arai M, Tsukiyama-Kohara K, Takagi A, Tobita Y, Inoue K, Kohara M. .  Resistance to cyclosporin A derives from mutations in hepatitis C virus nonstructural proteins. .  Biochem Biophys Res Commun.448 ( 1 ) 56 - 62   2014.5Resistance to cyclosporin A derives from mutations in hepatitis C virus nonstructural proteins.Reviewed

Kasama Y, Mizukami T, Kusunoki H, Peveling-Oberhag J, Nishito Y, Ozawa M, Kohara M, Mizuochi T, Tsukiyama-Kohara K. .  B-Cell-Intrinsic Hepatitis C Virus Expression Leads to B-Cell-Lymphomagenesis and Induction of NF-κB Signalling. .  PLos One9 ( 3 ) e91373   2014.3B-Cell-Intrinsic Hepatitis C Virus Expression Leads to B-Cell-Lymphomagenesis and Induction of NF-κB Signalling.Reviewed

勝目朝夫 .  Preclinical evaluation of an anti-interleukin 6 receptor antibody for Castleman's disease and a serene palmitoyltransferase inhibitor as an antiviral agent for hepatitis C virus .      2014.3Preclinical evaluation of an anti-interleukin 6 receptor antibody for Castleman's disease and a serene palmitoyltransferase inhibitor as an antiviral agent for hepatitis C virusReviewed

Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto Y, Kusanagi I, Fujiwara S, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M .  A serine palmitoyltransferase inhibitor blocks hepatitis C virus replication in human hepatocytes .  Gastroenterology145   865 - 873   2013.10A serine palmitoyltransferase inhibitor blocks hepatitis C virus replication in human hepatocytesReviewed

Kyoko Tsukiyama-Kohara, Asao Katsume,Kazuhiro Kimura, Masayuki Saito, and MichinoriKohara .  4E-BP1 regulates the differentiation of white adipose tissue .  Genes to Cells18 ( 7 ) 602 - 607   2013.74E-BP1 regulates the differentiation of white adipose tissueReviewed

Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y,Nishito Y, Yano J, Ochiya T, Tateno C, MizokamiM, Tsukiyama-Kohara K, Inoue K, Yoshiba M,Takaoka A, Kohara M. .  Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virusinfection. .  PLoS Onee59611   2013.3Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virusinfection.Reviewed

Salem NE, Saito M, Kasama Y, Ozawa M,Kawabata T, Harada S, Suda H, Asonuma K, El-Gohary A, Tsukiyama-Kohara, K. .  Genomic polymorphisms in 3β-hydroxysterol Δ24-reductase promoter sequences. .  Microbiol. Immunol.57   179 - 184   2013.3Genomic polymorphisms in 3β-hydroxysterol Δ24-reductase promoter sequences.Reviewed

S. Sekiguchi, K. Kimura, T. Chiyo, T. Ohtsuki, Y. Tobita, Y. Tokunaga, F. Yasui, K. Tsukiyama-Kohara, T. Wakita, T. Tanaka, M. Miyasaka, K. Mizuno, Y. Hayashi, T. Hishima, K. Matsushima and M. Kohara .  Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver. .  Pros Onee51656   2012.11Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver.Reviewed

K. Inoue, K. Tsukiyama-Kohara, C. Matsuda, M. Yoneyama, T. Fujita, S. Kuge, M. Yoshiba, and *M. Kohara. .  Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1. .  Biochem. Biophys. Res. Com. 428   494 - 499   2012.10Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1. Reviewed

Saito M, Kohara M, *Tsukiyama-Kohara K. .  Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1. .  Journal of Medical Virology84 ( 5 ) 733 - 746   2012.5Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1.Reviewed

Y. Kasama, M. Saito, T. Takano, T. Nishimura, M. Satoh, Z. Wang, S.N. E. S. Ali, S. Harada, M. Kohara, and *K. Tsukiyama-Kohara. .  Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3. .  Virus Research 163 ( 1 ) 405 - 409   2012.1Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3.Reviewed

M. Satoh, M. Saito, T.Takano, Y. Kasama, T. Nishimura, Y. Nishito, Y. Hirata, M. Arai, M. Sudoh, C. Kai, M. Kohara and *K. Tsukiyama-Kohara .  Monoclonal antibody 2-152a suppresses hepatitis C virus infection thorough betaine/GABA transporter-1. .  Journal of Infectious Diseses204   1172 - 1180   2011.10Monoclonal antibody 2-152a suppresses hepatitis C virus infection thorough betaine/GABA transporter-1. Reviewed

T. Takano, *K. Tsukiyama-Kohara, M. Hayashi, Y. Hirata, M. Satoh, C. Tateno, Y. Hayashi, T. Hishima, N. Funata, M. Sudo, and M. Kohara. .  Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes. .  Journal of Hepatology55   512 - 521   2011.8Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.Reviewed

Y. Kasama, M. Satoh, M. Saito, S. Okada, C. Kai and *K. Tsukiyama-Kohara. .  Evaluation of a recombinant measles virus as the expression vector of hepatitis C virs envelope proteins. .  World Journal of Vaccine1   98 - 103   2011.8Evaluation of a recombinant measles virus as the expression vector of hepatitis C virs envelope proteins. Reviewed

K. Tsukiyama-Kohara, S. Sekiguchi, Y. Kasama, N. E. S. Ali, K. Machida and M. Kohara .  Hepatitis C virus-related lymphomagenesis in a mouse model. .  ISRN Hematology2011   2011.6Hepatitis C virus-related lymphomagenesis in a mouse model. Reviewed

T. Takano, M. Kohara, M. Kasama, T. Nishimura, M. Saito, C. Kai and *K. Tsukiyama-Kohara .  Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response. .  Journal of Medical Virology83   801 - 809   2011.3Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response.Reviewed

Selective translation of the measles virus nucleocapsid mRNA by la protein. Y. Inoue, H. Sato, K. Fujita, K. Tsukiyama-Kohara, M.Yoneda, and *C. Kai. .  Selective translation of the measles virus nucleocapsid mRNA by la protein. .  Front. Microbiol. 2   173   2011.1Selective translation of the measles virus nucleocapsid mRNA by la protein.Reviewed

C型肝炎ウイルスによる肝がん発症機構

小原道法、小原恭子

別冊BioClinica   5 ( 1 )   14 - 18   2016.2

C型肝炎ウイルス感染動物モデル

小原恭子、小原道法

ウイルス   65 ( 2 )   255 - 262   2015.12

Role of Oxidative stress in hepatocarcinogenesis induced by hepatitis C virus. Reviewed

*K. Tsukiyama-Kohara.

Int. J. Mol. Sci.   13   15271 - 15278   2012.11

肝炎ウイルスモデル

小原道法、木村公則、小原恭子

Animal Models がん（中村卓郎編）   346 - 355   2012.10

C型肝炎ウイルス感染モデル

小原道法、木村公則、小原恭子

Animal Models 感染症（野本明男、喜多正和編）   188-197   2012.7

後迫玄城，村山典恵，小原恭子，山崎浩史，宇野泰広   ツパイCYP2A13 の同定と解析  

第165回日本獣医学会学術集会  2022.9  日本獣医学会

Md Abul Hashem, Mohammad Enamul Hoque Kayesh, Kyoko Tsukiyama-Kohara   Subtype distribution and expression of the koala retrovirus in koala from the Japanese zoo.   International coauthorship

2022.9 

Asako Takagi, Yutaka Amako, Daisuke, Yamane, Bouchra Kitab, Ahmed El-Gohary, Michinori Kohara, Kyoko Tsukiyama-Kohara.   Longer poly(U) stretches in the 3UTR are essential for replication of the hepatitis C virus genotype 4a clone in vitro and in vivo.   International coauthorship International conference

HCV-Flavi 2022  2022.7 

Chi Hai-Ying, Yuki Tanaka, Tatsuro Hifumi, Koichiro Shoji, Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Bouchra Kitab,Takahiro Sanada, Tomoko Fujiyuki, Misako Yoneda, Hitoshi Hatai, Akira Yabuki, Noriaki Miyoshi, Chieko Kai, Michinori Kohara, Kyoko Tsukiyama-Kohara   Pathological aspects of spontaneous mammary gland tumor in Tupaia belangeri (Tree shrew)  

第７９回日本癌学会学術総会  日本癌学会

長井誠、岡林環樹、松鵜彩、藤本佳万、Md Abul Hashem、目堅博久、中尾亮、松野啓太、片山幸枝、大場真巳、大松勉、浅井鉄夫、中川敬介、伊藤啓史、斑目広郎、河合一洋、伊藤壽啓、野中成晃、小原恭子、猪島康雄、水谷哲也、三澤尚明   次世代シーケンス(NGS)を用いた豚糞便中のウイルス検索：新しいBastrovirus遺伝子の発見  

第１６３回日本獣医学会学術集会  山口大学

伊藤伸将, Graham J Belsham, 迫田義博、小原恭子   CSFVのIRES発現細胞の作成と応用  

第163回日本獣医学会学術集会 

Md Abul Hashem, Mohammad Enamul Hoque Kayesh, Fumie Maetani, Kyoko Tsukiyama-Kohara   TRANSMISSION OF KOALA RETROVIRUS FROM PARENT KOALAS TO A JOEY  

第１６３回日本獣医学会学術集会 

Sayeh Ezzikouri, Kiminori Kimura, Shuichi Kaneko, Michinori Kohara, and Kyoko Tsukiyama-Kohara   Serum DHCR24 auto-antibody as a new biomarker for progression of hepatitis C   International conference

21st International Symposium on Hepatitis C Virus and Related Viruses.  

Sayeh Ezzikouri, Takahiro Sanada, Haiying Chi, Soumaya Benjelloun, Michinori Kohara, Kyoko Tsukiyama-Kohara   Horizontal and vertical transmission model of hepatitis B virus in Tupaia belangeri   International conference

2015 International Meeting on the Molecular Biology of Hepatitis B Viruses,  

Makoto Saito, Takashi Takano, Tomohiro Nishimura, Michinori Kohara, Kyoko Tsukiyama-Kohara,   DHCR24 on the Surface of HCV-related Hepatocellular Carcinoma Cells can be a Target for Molecular Targeting Therapy  

第７４回日本癌学会総会 

Nze Nkogue C, Fujita S, Horie M, Ogino M, Kobayashi Y, Mizukami K, Masatani T, Ozawa M, Ngomanda A, Yamagiwa J, Yamato O, Mizutani T, Tsukiyama- Kohara K   Infectious disease assessment in wild gorillas in African rainforest (Gabon): case of adenovirus  

第158回日本獣医学会学術集会 

松鵜　彩、所崎香識、寸田祐嗣、森田剛仁、川口博明、堀江真行、正谷達謄、中川寛子、奥谷公亮、川畑淑子、戸田重久、小原恭子、 小澤　真   2014-15年冬季に鹿児島県出水平野で分離されたH5N8亜型高病原性鳥インフルエンザウイルスの解析と感染野鳥における特徴  

第158回日本獣医学会学術集会 

木村公則、金子周一、小原道法、小原恭子   DHCR24自己抗体のC型肝炎新規病態マーカーとしての評価   Invited

第１１回広島肝臓プロジェクト研究センターシンポジウム 

Ezzikouri, S., Chi, H.Y.., Sanada, T., Nagano, K., Yamaguchi, C.., Kanda, T., Kanazawa, N., Okuya, K., Ueno, K., Nakagawa, H., Nkogue, C.N., Ozawa, M., Miyoshi, N., Benjelloun, S., Murakami, S., Tanaka, Y., Kohara, M., Tsukiyama-Kohara, K   Development of Tupaia belangeri for HBV persistent infection.  

第62回日本ウイルス学会 

Tsukiyama-Kohara K and Kohara M.   A comprehensive study of B-lymphoma cells spontaneously developed in transgenic mice that express the full hepatitis C virus genome in B cells.  

第37回日本分子生物学会 

Kohara M, Tokunaga Y, Tsukiyama-Kohara K, Sudoh M.   Inhibitor Inhibits Hepatitis C Virus Replication in Human Hepatocytes.  

第37回日本分子生物学会 

Sanada T, Yamamoto N, Tsukiyama-Kohara K, Ezzikouri S, Tateno C, Kohara M   HBV pathogenesis and host response in Tupaia belangeri   International conference

2014 HBV international Meeting  2014 HBV international Meeting

Masaaki Arai1,2, Kyoko Tsukiyama-Kohara3,4, Asako Takagi2, Yoshimi Tobita2, Kazuaki Inoue5 and Michinori Kohara   Resistance to cyclosporin A derives from mutations in Hepatitis C virus nonstructural proteins   International conference

HCV2014  HCV2014

池海英 1, Ezzikouri, S.1,2, 真田崇弘3, 永野希織1, 山口千穂1, 神田雄大1, 金澤伯弘1, 奥谷公亮1, 上野晃聖1, 中川寛子1, Nkogue, C.N.1, 小澤真1, 三好宣彰1, 小原道法3, 小原恭子   ツパイを用いたHCV感染・発症モデル系並びに治療評価系の開発  

日本ウイルス学会九州支部総会  日本ウイルス学会九州支部総会

Sayeh Ezzikouri a,b, Tomohiro Nishimura c, Michinori Kohara d, Soumaya Benjellouna, Yoichiro Kino c, Kazuaki Inouee, Akira Matsumori f, Kyoko Tsukiyama-Koharab   Inhibitory Effects of PycnogenolR on Hepatitis C Virus Replication  

日本ウイルス学会九州支部総会  日本ウイルス学会九州支部総会

Nze Nkogue C1,2, Fujita S3, Ogino M2, Mizukami K3, Masatani T3, Ozawa M 2,3, Horie M3, Ngomanda A1, Yamagiwa J4, Yamato O 2,3, Mizutani T6, Tsukiyama- Kohara K   Infectious disease assessment in wild gorillas in African rainforest (Gabon): case of adenovirus  

第157回日本獣医学会  第157回日本獣医学会

奥谷 公亮、川畑 淑子、永野 希織、小原 恭子、楠元 勇、高瀬 公三、小澤 真   ツルのインフルエンザウイルスに対する感受性の検討  

第157回日本獣医学会  第157回日本獣医学会

小澤真、川畑淑子、奥谷公亮、永野希織、神田雄大、金澤伯弘、小原恭子、出口栄三郎   豚トルクテノウイルスの遺伝的多様性  

第157回日本獣医学会  第157回日本獣医学会

Sayeh E, Kohara M, Kohara K   Inhibitory Effects of Pycnogenol on Hepatitis C Virus Replication  

第73回日本癌学会  第73回日本癌学会

Kyoko Tsukiyama-Kohara, Michinori Kohara, and Yuri Kasama   Comprehensive analysis of B-lymphoma cells spontaneously developed in transgenic mice that express the full hepatitis C virus genome in B cells   International conference

第16回国際ウイルス学会(ICV2014)  第16回国際ウイルス学会(ICV2014)

Tsukiyama-Kohara K., Kohara M.   Tumorigenicity inducued by hepatitis C virus.   International conference

第4回新学術領域 発がんスパイラル国際シンポジウム  第4回新学術領域 発がんスパイラル国際シンポジウム

Tsukiyama-Kohara, K, Hirata, Y., Sanada T, Yamamoto N., Sayeh, E., Yasui F, Kohara, M.   Development of Tupaia belangeri for small animal infection model of hepatitis B virus, according to the genomic research  

第36回日本分子生物学会  第36回日本分子生物学会

Tsukiyama-Kohara, K, Hirata, Y.,Sanada T, Yamamoto N., Yasui F, Kohara, M   Development of tupaia nelangeri for small animal infection model of hepatitis B virus, according to the genomid research   International conference

HBV2013  HBV2013

Tsukiyama-Kohara, K, Kasama, Y, Kohara, M   Critical factors in HCV related B-cell lymphoma development characterized by comprehensive analysis of B-lymphoma cells in the HCV transgenic mice   International conference

20th HCV Symposium  20th HCV Symposium

笠間由里、小原道法、小原恭子   C型肝炎誘発性リンパ腫発症モデルマウスの網羅的解析  

第72回日本癌学会学術総会  第72回日本癌学会学術総会

徳永優子、平田雄一、小原恭子、小原道法   宿主因子阻害剤NA８０８と直接的複製阻害剤の併用による抗HCV活性  

第72回日本癌学会学術総会  第72回日本癌学会学術総会

金澤伯弘、川畑淑子、永野希織、小原道法、小澤真、小原恭子   ツパイとヒトとの遺伝的相同性の検証  

第156回日本獣医学会学術集会  第156回日本獣医学会学術集会

小澤真、川畑淑子、出口栄三郎、小原恭子   養豚における抗インフルエンザウイルス抗体の保有状況  

第156回日本獣医学会学術集会  第156回日本獣医学会学術集会

神田雄大、小澤真、小原恭子   口蹄疫ウイルスのIRES依存性翻訳活性の評価  

第156回日本獣医学会学術集会  第156回日本獣医学会学術集会

Sayeh EZZIKOURI, Tomohiro Nishimura, Makoto Ozawa, Michinori Kohara and Kyoko Tsukiyama-Kohara   Efficacy of French maritime pine bark extract pycnogenolR to hepatitis C virus replication  

ウイルス学会九州支部会  ウイルス学会九州支部会

笠間由里、小原道法、小原恭子   C型肝炎ウイルスのBリンパ腫発症要因の解明  

第５０回日本ウイルス学会九州支部会  第５０回日本ウイルス学会九州支部会

小原 恭子   「C型肝炎ウイルス誘導性酸化ストレスによる肝細胞腫瘍原性亢進」（招待講演）  

第24回日本生体防御学会  第24回日本生体防御学会

K. Tsukiyama-Kohara, Y. Amako, M. Kohara   Chronic hepatitis C virus model in Tupaia belangeri（招待講演）   International conference

Symposium HCV Animal models and vaccine development  Symposium HCV Animal models and vaccine development

Kyoko Tsukiyama-Kohara, Kiminori Kimura and Michinori Kohara   Inflammation and Cancer in Hepatitis C virus infection（招待講演）   International conference

3rd IGAKUKEN International Symposium on "Control of Influenza and Hepatitis" Inflamation and cancer in hepatitis C virus infection  3rd IGAKUKEN International Symposium on "Control of Influenza and Hepatitis" Inflamation and cancer in hepatitis C virus infection

Takashi Takano, Kyoko Tsukiyama-Kohara, Michinori Kohara   Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes   International conference

Congress of European Association for the Study of the Liver (EASL2012)  Congress of European Association for the Study of the Liver (EASL2012)

Makoto Saito, Kyoko Tsukiyama-Kohara   Molecular target therapy for hepatitic C virus-related hepatocellular carcinoma with cell-surface expression of DHCR24  

第70回日本癌学会総会  第70回日本癌学会総会

Takashi Takano, Michinori Kohara, Kyoko Tsukiyama-Kohara   Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes  

第70回日本癌学会総会  第70回日本癌学会総会

Nagla Elwy Salem, Tomhiro Nishimura, Makoto Saito, Michinori Kohara , Shiniji Harada, Ahmed El-Gohary,and Kyoko Tsukiyama-Kohara.   Application of DHCR24 for the diagnosis of hepatocellular carcinoma (HCC).   International conference

International Union of Microbiological Societies 2011 Congress  International Union of Microbiological Societies 2011 Congress

Takashi Takano, Kyoko Tsukiyama-Kohara, Yuichi Hirata, Yuko Tokunaga, Chise Tateno, Masayuki Sudo, and Michinori Kohara   Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes   International conference

18th International Meeting on HCV and related viruses  18th International Meeting on HCV and related viruses

Kyoko Tsukiyama-Kohara, Yuri Kasama, Michinori Kohara   Spontaneous development of B-cell lymphomas by persistent expression of the full genome of hepatitis C virus in B cells   International conference

ASBMB2011 Recent Advance in Pathogenic Human Viruses  ASBMB2011 Recent Advance in Pathogenic Human Viruses

Asako Takagi, Yutaka Amako, Daisuke, Yamane, Bouchra Kitab, Yuko Tokunaga, Ahmed El-Gohary, Michinori Kohara, Kyoko Tsukiyama-Kohara   Longer poly(U) stretches in the 3UTR are essential for replication of the hepatitis C virus genotype 4a clone.  

2022.9 

抗DHCR24自己抗体検出による病態診断系

小原 恭子, 小原 道法, 木村 公則, 金子 周一

Molecular Basis of "Shut-off" mechanism by RNA virus.

Molecular Basis of Pathogenesis in RNA virus infection

RNAウイルスと翻訳開始段階の修飾

RNAウイルスの病原性発現機構

Study on Modification of Cell Growth Regulation by Hepatitis C Virus