Faculty Profiles - Jian-Jun Xu

Papers - Jian-Jun Xu

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Liang　HY, Qin L, Feng R, Shim J, Huang X, Xu XX, Zhao DY, Yu ZY, Boczek T, Li MX, Tong Y, Huang JW, Gao QH, Wang L, Cao XY, Liu DX, Du K, Xu JJ, Zhao Y, Wang WY, Seehus CR, Zhao WD, Guo F. . Increased Nav1.2 expression and its interaction with CaM contribute to the hyperexcitability induced by prolonged inhibition of CaMKII . Epilepsia66 ( 7 ) 2521 - 2537 2025.3Reviewed International coauthorship

Xin Tong, Yu Tong, Jiahe Zheng, Ruixue Shi, Hongyue Liang, Meixuan Li, Yulu Meng, Jian Shi, Dongyi Zhao, Corey Ray Seehus, Jialu Wang, Xiaoxue Xu, Tomasz Boczek, Sayuri Suzuki, Andrea Fleig, Reinhold Penner, Naining Zhang, Jianjun Xu, Jingjing Duan, Zhiyi Yu, Wuyang Wang, Weidong Zhao & Feng Guo . TRPM7 contributes to pyroptosis and its involvement in status epilepticus . Journal of Neuroinflammation12 (1) ( 315 ) 2024.12Reviewed International coauthorship

Masaki Kameyama, Etsuko Minobe, Dongxue Shao, Jianjun Xu, Qinghua Gao, Liying Hao . Regulation of Cardiac Cav1.2 Channels by Calmodulin . International Journal of Molecular Sciences24 (7) ( 6409 ) 1 - 28 2023.3Invited Reviewed International coauthorship

Xu Janjun, Minobe Etsuko, Kameyama Masaki . Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease . Frontiers in Cellular Neuroscience16 ( 867385 ) 1 - 15 2022.4Reviewed

Jia W, Liu J, Yu Z, Zhang X, Xu X, Wang Y, Gao Q, Feng R, Wan Y, Xu J, Minobe E, Kameyama M, Wang W, Guo F . Properties of Calmodulin Binding to Nav1.2 IQ Motif and Its Autism-Associated Mutation R1902C . Neurochemical Research46 ( 3 ) 523 - 534 2021.1Reviewed International coauthorship

Gao Qinghua, Minobe Etsuko, Kameyama Masaki*, Xu Jianjun* . Purification of insoluble GST-fused and GST-cleaved Cav1.2 channel fragment by denaturation and renaturation. . Protein Expression and Purification160 7 - 10 2019.3Reviewed

Li J, Yu Z, Xu J, Feng R, Gao Q, Boczek T, Liu J, Li Z, Wang Q, Lei M, Gong J, Hu H, Minobe E, Ji HL, Kameyama M, Guo F . The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to Nav1.1 . Int J Mol Sci19 ( 9 ) 2018.8Reviewed

Lei M, Xu J*, Gao Q, Minobe E, Kameyama M, Hao L* . PKA phosphorylation of Cav1.2 channel modulates the interaction of calmodulin with the C terminal tail of the channel. . J Pharmacol Sci137 ( 2 ) 187 - 194 2018.6Reviewed

Wu M, Takemoto M, Luo H, Xu JJ, Lu MH, Kameyama M, Takumi T, Song WJ . A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1 . European Journal of Pharmacology 824 99 - 107 2018.4Reviewed

Lyu L, Gao Q, Xu J, Minobe E, Zhu T, Kameyama M . A new interaction between proximal and distal C-terminus of Cav1.2 channels. . Journal of Pharmacological Sciences 2017.3Reviewed

Chang Seok Lee, Amy D. Hanna, Hui Wang, Adan Dagnino-Acosta, Aditya D. Joshi, Mark Knoblauch, Yan Xia, Dimitra K. Georgiou, Jianjun Xu, Cheng Long, Hisayuki Amano, Corey Reynolds, Keke Dong, John C. Martin, William R. Lagor, George G. Rodney, Ergun Sahin, Caroline Sewry & Susan L. Hamilton . A chemical chaperone improves muscle function in mice with a RyR1 mutation. . Nature Communication 2017.3Reviewed

Yu L, Xu J, Minobe E, Kameyama A, Yang L, Feng R, Hao L, Kameyama M. . Role of protein phosphatases in the run down of guinea pig cardiac Cav1.2 Ca2+ channels. . American Journal of Physiology Cell Physiology310 ( 10 ) C773 - C779 2016.5Reviewed

Xu J, Yu L, Minobe E, Lu L, Lei M, Kameyama M. . PKA and phosphatases attached to the Ca(V)1.2 channel regulate channel activity in cell-free patches. . American Journal of Physiology Cell Physiology310 ( 2 ) C136 - C141 2016.1Reviewed

Sun Y, Xu J, Minobe E, Shimoara S, Hao L, Kameyama M. . Regulation of the Cav1.2 cardiac channel by redox via modulation of CaM interaction with the channel. . Journal of Pharmacological Sciences128 ( 3 ) 137 - 143 2015.7Reviewed

Shu-yuan Liu, Jian-jun Xu, Etsuko Minobe, Qing-hua Gao, Rui Feng, Mei-mi Zhao, Feng Guo, Lei Yang, Li-ying Hao, Masaki Kameyama . Nucleotides maintain the activity of Cav1.2 channels in guinea-pig ventricular myocytes. . Biochemical and Biophysical Research Communications460 ( 3 ) 813 - 818 2015.5Reviewed

Minobe E, Maeda S, Xu J, Hao L, Kameyama A, Kameyama M. . A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation. . Am J Physiol Cell Physiol306 ( 9 ) C856 - C863 2014.12Reviewed

Shao D, Zhao M, Xu J, Feng R, Guo F, Hu H, Sun X, Gao Q, He G, Sun W, Wang H, Yu L, Liu S, Zhu Y, Minobe E, Zhu T, Kameyama M, Hao L. . The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart. . FEBS Lett588 ( 21 ) 3855 - 3861 2014.11Reviewed

Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL. . Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function . J Biol Chem289 ( 37 ) 25556 - 25570 2014.9Reviewed

Feng R, Xu J, Minobe E, Kameyama A, Yang L, Yu L, Hao L, Kameyama M. . Adenosine triphosphate regulates the activity of guinea pig Cav1.2 channel by direct binding to the channel in a dose-dependent manner. . Am J Physiol Cell Physiol 2014.2Reviewed

Yang L, Xu J, Minobe E, Yu L, Feng R, Kameyama A, Yazawa K, Kameyama M. . Mechanisms underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea pig ventricular myocytes. . J Physiol Sci. 2013.7Reviewed

Han DY, Minobe E, Wang WY, Guo F, Xu JJ, Hao LY, Kameyama M. . Calmodulin- and Ca2+-dependent facilitation and inactivation of the Cav1.2 Ca2+ channels in guinea-pig ventricular myocytes. . J Pharmacol Sci.112 ( 3 ) 310 - 319 2010Reviewed

Hao LY, Wang WY, Minobe E, Han DY, Xu JJ, Kameyama A, Kameyama M. . The distinct roles of calmodulin and calmodulin kinase II in the reversal of run-down of L-type Ca2+ channels in guinea-pig ventricular myocytes. . J Pharmacol Sci.111 ( 4 ) 416 - 425 2009Reviewed

Hao LY, Xu JJ, Minobe E, Kameyama A, Kameyama M. . Calmodulin kinase II activation is required for the maintenance of basal activity of L-type Ca2+ channels in guinea-pig ventricular myocytes. . J Pharmacol Sci.108 ( 3 ) 290 - 300 2008Reviewed

Nie HG, Hao LY, Xu JJ, Minobe E, Kameyama A, Kameyama M. . Distinct roles of CaM and Ca(2+)/CaM -dependent protein kinase II in Ca(2+) -dependent facilitation and inactivation of cardiac L -type Ca2+ channels. . J Physiol Sci.57 ( 3 ) 167 - 173 2007Reviewed

Minobe E, Hao LY, Saud ZA, Xu JJ, Kameyama A, Maki M, Jewell KK, Parr T, Bardsley RG, Kameyama M. . A region of calpastatin domain L that reprimes cardiac L-type Ca2+ channels. . Biochem Biophys Res Commun.348 ( 1 ) 288 - 288 2006.1Reviewed

Zhou FW, Xu JJ, Zhao Y, LeDoux MS, Zhou FM. . Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata. . J Neurophysiol.96 ( 3 ) 1581 - 1581 2006Reviewed

Jian-Jun Xu, Li-Ying Hao, Asako Kameyama, Masaki Kameyama . Calmodulin reverses rundown of L-type Ca(2+) channels in guinea pig ventricular myocytes. . American Journal of Physiology Cell Physiology287 ( 6 ) C1717 - C1724 2004.11Reviewed

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